>ENSDARP00000013881 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------------MT-------- ---PARARA---------------LLGLLVTLCTQSP----------------------- ------------------------L---------------------LSGSKPL------- -----------------------PPRNVKLTSVDKGLKVTWDPPSELDGQPV----DSYS ------------------------------------------------------I-GYGK S-----------------------------------------------MK---------- -----------SLRYVTVDKDRRSELLEDV--------------------------EPGV LHFLKMSAENKD--------GMSKPVYRAETPG--------------------------- -------------------------------------------------------GG--- ---------------------------------EWVKLDGFAVE---P------------ ------------------FN---------------------------------------- ------------------------------------------------------------ ----RSSPG--------------------------------------------------- ----------------------------------------------------RMVSITSS QINPRPPTQRTALGHQ---------RAPQSSSGPEPPHQIGRLPI-R------------- PLNKHRVDL------------SQHQADQRNANKPKL---ASESV---------------- ---------YVVSLQA-----------------PRAQGRSAPINTATMSKKVITES---- ---EVVDEVEDITVRVLSPQSVLITWVDPPVE-KNK-EIPGGS-RYYRVKYREKGESARW EYKDTTQRRLMIETLSADSMYEFSICISQGNHMGKWSASVFQRTPESAPSGPPENFEVKP LRGKGTAVTATWDPPEQTNGRLREYILSYAPAMKPFGAKSVTYRGTTTSATIDGLTPGDR YIFKIRAVNRKGQGPQTKAIIVSMPA-----------S-SNTH----------------- ------------------------------------------------------------ --------TR------------------N----MDSQRTSQ-------STSKTSSN---- ------------------------------------------------NESDYQEPDEME E----------------------------------------------------------- -PNTQTTTQAPNTNRRRPLSQTRSYHSIFSSVRGSVRNGGSKSNLHTSSTH--------- ----------------------------------TKDRED-------------------- ------------------------------------------------------------ --------EEK--------------------------------PTADS------PIEE-K TGANEATE---------------------------------------------------- ------------------------------------------------------------ ----------------------DT------------------------------------ ------------------------------------------------------------ ----------------NPE----------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------RSN----------------------- NA---------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------SP--------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---QTQ-------------EHSKLSPDTKESKPSNSDIVPKTSEDKRPPW---------- ------------------TPRTSSIVDISRLR---------------------------- ---------------------------------------------------RPSSRS--- -------GSRSRMRSEDTSSSSLNQESAA-------------TRKDLTAVSYPDGQKSHN QITVTDSMPSVASPQENRPEPVKESEPSSSISSSP------------------------- ------------------------------------------------------------ ------------------------TYSSSAS----------------------------- --------------------------------SSSSSVSSP-----------------SS ------------------------------------------------------------ ------------------------------------------------------SLP--- ------------------------------------------------------------ --------------------------------------------------------SSSG TRRFSSGASGAKYP--------------------------NGRRV--------------- ------------------------------------------------------------ ----------------------------------GISTRGQRLQTG-------------- ---------KPKP----------------------------------------------- -----------------------------DS----------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------SSSASSQSTLPTGT------------------------------ -STDNHDTTEVHDTNQKITKLNTEELPVPKENDDNEEKT--------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------VDST-------------------------------------------- ---------------------------S-------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------------HSSSRTNPS TT----GR---------------SSSFSLPNRNSRIVT-SSR---RQDGRIP-------- ------------------------------------------------------WSRSA- ------------------------------------------------------------ ------------------------------------------------------------ ----SSV----------------------------------------------------- -------------------GAG---------------------------RPIIK------ ----------------------------------------------------------GF PSRS---------------------------------------TSV-------------- ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------------S S--------------------------------------------------QDTSDKNKV SPTVYPKHKVNPVSNKPSLLN--------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------VKSSN--DHED--------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------DYLYEGSKEIWDRQTKDV------ --------------------------VSTTAPKTTTAVSESHKPVQNFENESVDREQSSM S-------------TGFKTVPS-------------------------------------- -----------------VPHKL-----PTVT----------------------------- ------------------------------------------------------------ ----------------------------SNGRV--------------------------- ----------------RSPVVS--RLKG-------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------SRFPSR------------------------LYPLQHRRLGASTP DTSAASSQNNPAAESPLTSDRDRAASSNANVRLASGSVSRPSQGLSAGESSSGNISPESR SPVMGSRLRSAS---------TPGNSYKPSF------G------K--------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------GKNGRPNLTAA-------- --SGK-VSSTSDENPKPNGVRHITGPDGTKWILDLDKGVLMNENGRVLQDSKGRPRKVIL GEDGKTIFDDQGSPLVNQEGLALFGHGRDSRPVNNPSDK-YLTVGGKPIVGLD--RPKLR T--T-TT----------------------------------T--TTS------------- --------ST-----------TTT------------------------------------ --------------------------------------------------------P-TT ----------TTTTPTTTTA------------------------EPTTEMVTETVEPSTL AADPTCPPGLYSRLDKNGLPIL-DAEGILNCY--------------------------S- -------------------------------------------------------ED--- ---------------------E--------LF-EE-STT-------I-----P---VPL- ------PTTTLA------------------------------------------STTQ-- T-----------LT---PETRP----------------------F--------------- -----NNTPSSEFDVTGKKRFT--------------------------APYVNYIQKDPG APCSLTEALEYLQVDVLADLMEKDQQSSNQKQPPKNKPHNVTVVAMEGCHSFVILDWARP LKDDMVSGYMVHSASYDDVLNNRWSEQPSTGTHLPVENLKPNS----------------- -------------RYYFRVQAKNIFGLGPFSETLTYVTESDDPLLIARPPG--------- ------GEPIWIPFSFRYNQAHSSCRGSQFVKRTWYRKFVGVVLCNSLRYKIFMADGL-R -ETFYSLADTFGHGEDHCQFVDSHLDGRTGPHNLSLNLPTAQGYYRSYRQEPVNFGAIGR RTPHPFVGWYECGVPIPGKW---------------------------------------- ------------------------------------------------------ >ENSIPUP00000034094 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------------MC-------- ---PPAARA---------------LPALLLALCSLSP----------------------- ------------------------M---------------------LTAFKPL------- -----------------------HPRNVKLTSVEKGLRVTWDPPNELDGRPV----DRYS ------------------------------------------------------I-GYGK S-----------------------------------------------MR---------- -----------SLRFIKVDKDRRSEVLEDV--------------------------EPGV LHFLKINSENEE--------GMSKPVYRAETPG--------------------------- -------------------------------------------------------GG--- ---------------------------------EWVKLDGFAVEGGSS------------ ------------------AN---------------------------------------- ------------------------------------------------------------ ----ASSPG--------------------------------------------------- ----------------------------------------------------RRSSELSS QISPRPTVQRPTLLRQ---------RAPQSSSGPEAPRRGGYLPI-R------------- SQNKHRVDL------------SQPQADQRNANKPKL---ASESI---------------- ---------HVISLQAQKAPQRNIPVSKTENPPP--------------------ER---- ---DVVEDVEDITVRILSPQSVVITWVDPLVQ-KQK-GIPEGT-RQYTVRYREKGESARW EYKETSQRRLVIEKLSADGMYEFSVRITQGDQHGKWSVSVFQRTPESAPSGPPENFEVRP LRGKGTAVTATWDPPDEPNGKIREYILSYAPALKPFGAKSVTYRGTTTSATIDGLTPGDR YIFRIRAANRKGQGPQSKTLSVAMPG-----------T-STTA----------------- ------------------------------------------------------------ --------SRHSTQSKSPSRTSEYDDSQD----QDTEDT--------------------- -----------------------------------------------------------E E----------------------------------------------------------- -SQTHTTTSPPTNKKFRPLSQTRSYHSIFSSVRGSVRNSGSSS--RTSISS--------- ----------------------------------DKERNE-------------------- ------------------------------------------------------------ --------EET--------------------------------PT-DT------PKED-E ATANEAVE---------------------------------------------------- ------------------------------------------------------------ ----------------------DI------------------------------------ ------------------------------------------------------------ ----------------QPE----------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------NTN----------------------- NVPSKTGEEE-------------------------------------------------- -QPKVSAGAKEPSSILR----------------------------SSLLKTHSSP----- ------------------------------------------------------------ ----PMPKEGHHQSQS--------------------LTP--------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---RT------------------------------------------------------- -----------------------SVVNAGRLR---------------------------- ---------------------------------------------------RP------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------PFS-----SSRSRNQKGASS ------------------------------------------------------------ ------------------------------------------------------SLPNSQ DPVVSKKVHTILYPEDKVSTTAAQSSTPSPHETKMETERESSSLSLSLPLSSA-----GT SRVSN----PTSH------------------------------------------SSSSG T--------GPVYP--------------------------NGRRVTQTKGHRYQTSRQKT ALPSSALSQASTGSSTGYQDSRSTSIVDTKHDNKKDHKIKIKNNDDPPASYQYTTTLSPS IKEETTQDLGNKNYKDKAVNSYLPSSQSPSTASPG------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------------HSS------ ---------------------------SLSNRNSRVVVGSSQ---RKDGRIP-------- ------------------------------------------------------WSRTA- ------------------------------------------------------------ ------------------------------------------------------------ ----SSV----------------------------------------------------- -------------------GAG---------------------------RPILR------ ----------------------------------------------------------GM PSN--------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------PTATGGHVSGKNKTSPTTYTTKHLDDSNLAKPT VNSRQPVSSNGQTTSNDHTDKEDTNPSNDHKHDYLSEVNKETREISNTNSVPTASPKTVA SDDKEVQRSGKTSQNNSPYMTLNRLGLGSNGKV--------------------------- ----------------RSALLE--RLRG-----RLQTVQN----------T--------- -QLGSAAKQNASSSPVSASS---------------------------------------- ------------------------------------------------------------ ----SSSASQ-----TMEHKASPSDHGTDGSQSANVRSTM-------------------- ------------------------GS-------------VSRSSLKQTATDQNSGGDTPT DFKTSLTAPARNPVVRSRYPSRPDKNSRG------------KPPVSL------------- ------------------------------------------------------------ --------------------------HKPSY------G------Q--------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------GKNGRPNLTAT-------- --NGK-IASTSDENKKANGVKYITGPDGTRWVVDLDKGVLMNEEGKVLQDSRGRPRKVVV GEDGKTIFDEQGTPLVNQEGMALFGNGRDGRPVVNPRDK-YLTVGGKPVVGLD--RPTPS T--T-TT----------------------------------T--TT-------------- --------TT-----------TPT------------------------------------ --------------------------------------------------------P-TT ----------TTTTTTTTTTTAE----STTTEIT--------TLESTTE----------- -ALPTCPPGTFPRLDMNGIPVM-DVYGILDCY--------------------------P- -------------------------------------------------------SD--- ---------------------E--------FL-ME-TTM-------F-----P---T--- -------TTQVP------------------------------------------TTTH-- T-----------PT---TEFRF----------------------F--------------- -----NHSPSSDFDVAGKKRFT--------------------------APYVNYIQKDPG APCSLTEALEYLQVDVLADLIEKDRGTTIQKQPPKYKPHNITVIAMEGCHSFVILDWARP LKDDMVSGYMVQSASYDDVLNNRWSSTLSSGTHLAVENLKPNS----------------- -------------RYYFRVQAKNVFGLGPISETLTYVTESDNPLLIERPPG--------- ------GEPIWIPFTFRYNHAHSSCRGSQFVKRTWYRKFVGVVLCNSLRYKIFMGDGL-K -ETFYSIADSYGNGEDHCQFVDSHLDGRTGSQTLSLYLPQAQGYYRSYRQEPVNFGPIGR RTPHQFVGWYECGVPIPGKW---------------------------------------- ------------------------------------------------------ >ENSDCDP00000059631 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------------MS-------- ---LTAAGA---------------LLALFIPLSTICP----------------------- ------------------------L---------------------LIAEKPL------- -----------------------RPRNVKLESVERGLKVTWDAPNELDGRPV----DRYS ------------------------------------------------------I-GYGK S-----------------------------------------------LK---------- -----------SLRVITVDKERRSEVLEDV--------------------------EPGV LHFLKMSAENKD--------GLSKPVFRAETPRG-------------------------- --------------------------------------------------LFTRLGP--- ---------------------------------EWVKLDGFPIVSGSP------------ ------------------AN-STAMV---------------------------------- ------------------------------------------------------------ -GSPR------------------------------------------------------- ------------------------------------------------------------ -----PLANRAPGGQL---------RAPQSSSGPRQ-------PV-RARV-----PAPVQ TVTRSRVDV------------SQPQADQRNQNKPKL---ASESV---------------- ---------YVVSLQAQR-----------------ALGRSAPAKPALVSKKMPPEP---- ---EPVDEAEDITARVMSPQSVLITWVDPLIDKKKK-SVPEGS-RAYAVRFREKGESARW EYKDTTQKRFLVEGLSADSMYEFSIRISQGESHGKWSTSVFQRTPESAPTGPPESFEVKP IRGKGTAVSASWDPPEEPNGRIREYILSYAPALQPFGSKSITYRGSTTSATIDGLQPGNR YIFKIRAVNRRGQGPQTKAIMVAMPT-----------S-TAASAAT-------YHSSTS- ------------DRQR-------------------------------------------- --------SRHTS-------TDEHDDT-D----EETRVT--------------------- -----------------------------------------------------------E E----------------------------------------------------------- -PNKISTISPPITRRTRPLSQTRSYHSIFSAVRSPIKNVGTST--RTTSSSTKG------ ---------------------------------RKKENEE-------------------- ------------------------------------------------------------ --------EEE--------------------------------PT-DI------PKKE-- ------------------------------------------------------------ ------------------------------------------------------------ ----------------------DVV-----------------KKND--------ATDVNE YAGT-------------------------------------------PNNKMPSAEDKQN INGHSATATDTSRHRQRP------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------NPFSLDS TEKTKVGQHITPGITSHYPSE-------------------------PNSDQVRKPLTSIS NEMHPEPKK----------------------------SP--------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------SSSTI----------------------------- --------------------------------SPSTSSSRP-----------------SS S--------------------PSL------------------------------------ -----------------------------SGSSQQ----------------AASSKP--- ------------------------------------------------------------ --------------------------------------------------------SV-- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------P----------------------------------------------- -----------------------------KS----------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------RHTGSGYAYINGRKYT VPSRVSR----------------------------------------------------- -------------------------------PVIS------------------------- ------------------------------------------------------------ ---TQKNVVGSSTDRSQILQSAGSSPYPSIQDTRTERNFDVHKILKDTTLDEVPTSKPAT GHSTKDKDINEHDGEKEETEDSSQSITSGHSFRI-------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -NPSLSGR---------------G----------RSGF-VNRYQPRKDGRIP-------- ------------------------------------------------------WSRTAQ ------------------------------------------------------------ ------------------------------------------------------------ ----SS------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------SSTGFGR----SIHPAASEALNTTDKSGEHSKHLHS KHSK----------------DSGSPKPSESVLTKPHNRIQQGNPRSDNDHDETYLHEDTK KDSEKADNVFVTTAAPKPTASVQSKPYNAVQMSENESVDGE-----------GRPDTSRP ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------VPS-------------------------------------- -----------------YPRR--------------------------------------- ------------------------------------------------------------ ----------------------------SNGRS--------------------------- ----------------RSSVIAS-RQNGSRFPGRLMPAQH----------T--------- -KIAP--KPNGSTSNLPSSSP---------------HSQSIPKPFLTSDQRSSSD----- -----------------------------RDSAGNEKTSQGSVLRSPISRTSPSGEGSQR SVHLSQASS----------------------------DPRSSSALP-------------- ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------------R SPVVGSRLRSPSRIDSILRGS--------SYKENKVQG------Q--------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------GKNGRPNLTTS-------- --DGK-ALSTTDEIHKENGHRFITGPDGSRWIVDLDKGVLMNEQGKVLQNSQGQPRRVVL GEDGRTIFDEQGTPLLNQDGMALFGHGRDTRPVVNPKEK-YLTVGGKPIIGLD--RPKPQ T--T-S------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------------------P-TT ----------TTPEP-TTTA--EPSTFPTTTEMT--------TLE-----------PSSF PVTATCPPGTFSVMDELGLPMV-NVDGVLDCY--------------------------P- ------------------------EENG-SGMGMDTMVTV---TMAP-GTAFAIEED--- ---------------------E--------FV-MD------------------------- --------TISP------------------------------------------PTTM-- T-----------PTTPEHDTRH----------------------F--------------- -----NSSPSSEFDLAGRKRFT--------------------------APYVNYIRKDPG APCSLNEALEYLQVDVLEILMEKDT--ANQKQPPKNKPHNITVVAMEGCHSFVIIDWARP MKDDMVSGYLVHSASYDDVLNNRWSTSSSAGTHLPVENLKPNS----------------- -------------RYYFKVQARNIFGLGPISETITYVTESDDPLLIERPPG--------- ------GEPIWIPFTFRYNAAHSACKGSQFVKRTWYRKFVGVVLCNSLRYKIFMGDGL-R -DTFHSIADSSGHGEDHCQFVDSYLDGRTGPHNLSVYLPTAQGYYRSFRQEPVNFGPIGR RTPHTFVGWYECGVPIPGKW---------------------------------------- ------------------------------------------------------ >ENSCHAP00000052707 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------------MS-------- ---PAAARS---------------LLALYVVLSAVCP----------------------- ------------------------L---------------------LPASKPL------- -----------------------QPRNVKLTKVDKGLQVTWDPPNQLDGRPV----ERYN ------------------------------------------------------I-GYGK S-----------------------------------------------MR---------- -----------TLRFITVDKDQRSEILEDV------------------------------ ------------------------------------------------------------ -------------------------------------------------------GP--- ---------------------------------EFVKLDGFAVESTTP------------ ------------------RNSSTGRF---------------------------------- ------------------------------------------------------------ -GGPRSSPQ--------------------------------------------------- ----------------------------------------------------RSQ----- ----KP---------L---------RAPQSSSGPRQ-------PV-RAQE-----QPSSQ AVTSHRVDI------------SQPQADQRNQHKPKL---ASESV---------------- ---------YVVSLQAQR-----------------ALGRSAPVNKAVVHKKHTPEP---- ---VEVDEAEDITVRVMSPQSVLITWVDPLIEKKKK-TVPEGS-RQYTVRYREKGESARW EYKDSSQRRLMVETLSADGMYEFSVRISEQDRHGKWSTSVFQRTPESAPSGPPENFQVKP LRGKGTAVTATWDPPEEPNGRLREYIMSYAPALKPFGAKSISYRSSTTSTTVDGLQPGER YIFKIRAVNRRGQGPQTKAFSVVMPT-----------S-TSASSPS-------HHLRTT- ------------DRHKPSR----------------------------------------- -------GESRTS-------EDDYNDT-DTDLQEPTTVT--------------------- -----------------------------------------------------------A E----------------------------------------------------------- -PRRESTTAAPASRRTRPLSETRSYHSVFSA---------------------RGSSR--- --GAGASRSR------------------GREREKEKKEEE-------------------- ------------------------------------------------------------ --------EEK--------------------------------PI-DP------PKEEEE ATVNEATEEEKRKHTEEEKRKQTEEEKRKQTEEEKRKHTDT------------------- ------------------------------------DAHGHKTASKADEHHDYSKASLGS S-------SKVS-----VGSSAD------------------------------------- ------------------------------------------------------------ ----------------RP------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------TP----- ------------------------------------------------------------ ------PSE----------------------------TPA----------K--------- ---------------------------------EPERGRSSPSHP--------------- ------------------------------------------------------------ --------------------------------------HS-------------------- STHQT----------------------SGAGQP--------------------------- -------------------------------R---------------------------- ---------------------------------------------------RPLTRNPVV RSRVRNGGS--------------------------------------------------- ------------------------SSPSSSSRSSPSAPKESGVAVRDSSRG--------- ------------------------------------------------------------ --GQQDRKGTPTSDTEIRPEADTSSSSSSSS----------------------------- --------------------------------SPSSSSSSP-----------------SS S--------------------PSS------------------------------------ -----------------------------SPSSSSP-------------PLSSDSSP--- ------------------------------------------------------------ --------------------------------------------------------SS-- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------P----------------------------------------------- -----------------------------DS----------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------SSGSSSSST----------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------SS-------------------------------------------- ---------------------------S-------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------AS---------------------------------- -----GSGQSGN-----------------SRTSSSST----------------------- ------------------------------------------TGRFTGSGSVMINGRKVT LPSRWNRLMT-----------------------GQRKPGSGFTSTSTGSGSTSQ------ --------------------TQNQNQNKESAP---------------------------- ------------------------------------------------------------ -------------------------PSPSIQDT--------------------------- ---------------------------------IGPQESNRESQPSTR------------ ----------RQ-----TTKDEEPTTS--------------------------------- -------YETSSSH--SSVAKKDGADETKRA----------EEE---------------- --------------------------------------------GKQGSSPHSSSRQSPS LTPSHSGR---------------GASSALPSQNARPGV-VQRFPPRQDGRIP-------- ------------------------------------------------------WSRTSS ------------------------------------------------------------ ------------------------------------------------------------ ----SSV----------------------------------------------------- -------------------GNR---------------------------RPVLRANTPRL DVSETPERGDKTRTAS-----------------------------------------SSY PS---------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------KHKLDDTSPKPSVLNRDRVSTG-------------------------------- ------------------------------------------------------------ ---------------------------------------------------------SRP H--------------------------SSTRTDSHTPKQSSQIDN--DHED--------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------DYDYE-----------DYDKYDKV AEPTAAFKTTTSSTTTTTTTTASTTRTTTTAPTTTTASTAS--PVQR------------- SGDYSERRGQIPGRTGSQSVPP-------------------------------------- -----------------YGRR------P-------------------------------- ----------------------------------LQ------------------------ ---------------------------GSNGRT--------------------------- ----------------RSPVIASNRQGGSRFLGRLSPVQH----------T--------- -KLGS--KPDSSSPHLSSSS---------------------------------------- ------------------------------------------------------------ ----SSSSS----------------------------SSQSSRGLPKPSQVSEQDVS--- -----------------NSRIPSSGS-------------VSRSSGRQI------------ --------PGENPPI--------------------------------------------- --------------------------------ISSG--SQPS-------------SPVER SAVVGSRLRNPSRFDSILRGKTPVNGFKPSYGQ-----------A--------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------GKNGRPNLTTS-------- --NGK-VTSPSSSESKVNGRKYITGPDGTKWVVDLDKGVLMNQEGKVLQDSQGQPHRVVL GEDGRTVFDLQGTPLVNQDGMALFGHGRDSRPVVNPKEK-ILTVGGKPVVGLD--RPRAR T--T-TT----------------------------------T--TTT------------- --------TT-----------TTT------------------------------------ -------------------------------------------------------EA-TT ----------TTPEP-TTVS--------TTTEMT--------TEE-----------SMTT EVNPTCPSGTFFAMDDHGQPML-NDYGVLDCY--------------------------P- -------------------------------------------------------ED--- ---------------------E--------FV-ME-STV-------L-----P------- -------TTQNP------------------------------------------PTTS-- T-----------LPDPSPHTRP----------------------F--------------- -----NSNPVSEIDLAGKKRFT--------------------------APYVNYIQKDPG SPCSLTEALEYMQVDVLEGLFKKDSPLANQNLPPKNKPLNLTVVAMEGCHSFVILDWDRP LPDDSVSGYLVHSASYDDVLNNRWSTSPSAGTHLPVENLKPNS----------------- -------------RYYFKIQAKNVFGLGPVSDTLVYVTESDDPLLIERPPG--------- ------GEPIWVSYKFRYNPAHSTCKGSQYVKRTWYKKFVGVVLCNSLRYKIFMADGL-K -DTFYSVADSFGYGEDHCQFVDSYLDGRTGPHSLSTYLPTAQGYFRSYRQEPVNFGRIGR QTPHNFVGWYECGVPIPGKW---------------------------------------- ------------------------------------------------------ >ENSELUP00000036196 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------------MA-------- ---STAART---------------LLVLAI-FCASNP----------------------- ------------------------G---------------------LTADKPL------- -----------------------QPQNVQLASVDKGLRVSWDPPNELDGRPV----DSYT ------------------------------------------------------I-GYGK S-----------------------------------------------MK---------- -----------TLRFLKVDKDRRSEVLEDV--------------------------EPGV LHFVKMSAENKE--------GMSKPVYRAETPG--------------------------- -------------------------------------------------------GG--- ---------------------------------EWVKLDGFAVVGGAP------------ ------------------ANTSLAR----------------------------------- ------------------------------------------------------------ ---PSLTPDTRPWHDPLIRTG--------------------------------------- -------------------------------------ARVNGALRPSGLTSPRGQRI--- ---------------R---------RPPQSSSGPRQ-------PE-RARA-----GTPLL DQRSHQYHH------------TQPQADQRNRRNPKL---ASESV---------------- ---------YVVSLQAQR-----------------ATERRASSNRAALTKKSPPEP---- ---EEY-EAKDIGVRVMSPQSVLISWVDPAIE-MDK-VQPGGA-RYYTVKYREKGESARW EYKDTTQRRLLIDTLSADGMYEFSVRISQGENHGKWSVSVFQRTPESAPSGPPENFDVKP LRGKGTAVTATWDPPEEPNGRIREYIMSYAPAMKPFGMKTVTYRGSITSAIVDGLKPGDR YIFKIRATNRRGQGPQTKAFSVAMPG-----------G-TASSVVSSP----APHLKPQ- ------------RDHRT------------------------------------------- --------------SHNPSKTSKQDSNHDDDINLQTEDV--------------------- -----------------------------------------------------------T EV---------------------------------------------------------P TTTSHTTSVLPVVRRTRPLSQTRSYHSIFSDVRGSVRNG-----------------VTNH RLGGGTSSPR------------------GKGRETERKAQKNEDKTTEP-----------T PA---------------------------------------------------------- -----ERNEEK--------------------------------LT--------------- ---NEAVEEKK------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ YVV--------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------SP----- ------------------------------------------------------------ -------------------------------------TP--------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------EEKD-------------- ---------------------------------------------RDHGRGKV------- -------------------------------------------LPVDVTSNPSLKTDISS SEG--------------------------------------------------------- ----------------------------------SLSSSKP-----------------SY SLRKPLSGRRVNSGRRQFTRIPSI------------------------------------ -----------------------------SGSVSQTKTQ--DAEKEKSTASSSSSSP--- ------------------------------------------------------------ -----------SHGQESAAIRKDDTVTNYPT-----------------GKNTYNQPSVME TKLFS------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ----------PTP----------------------------------------------- -----------------------------DQH-----------VQKPQTEAPSTS----- ------------------------------------------------------------ -----------------------------------KGSILPG------------------ ---------------------------------------R-------------------- ------------------------------------------------------------ -----------------------------------------------------G------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------YGYGR-----------------------------------RTPGIQPR G-----------------------------------SPN---IRILTGIRK--------- ---------------PGSGSTSQSTLPT-------------------------------- -----------------------------------EGKT--------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------PEMS------------------------- ---------------------------HTNRDHNPK------------------------ --LT-------------------------------------------------------- ------------------------------------------------------------ -----------E-----TAKEEEPTSSPPVISTTHFSEEDMTEEENNETPAPPPSRTNPF VNRHQSRFDT-------------------------------------------------- ---------------------------------------------------RSSSRV--- ---------------------------------------SS---PRADGKVP-------- ------------------------------------------------------WSRTAS ------------------------------------------------------------ ------------------------------------------------------------ ---SSSV----------------------------------------------------- -------------------GAG---------------------------RPILR------ --------GGLSRTAASRAAESSGASRISAVQETSEDSITPSTLHPLKNSVGDGSLKSTL PSRSDVLGGLRKP------------------------ITSSGGT---------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------------------DSSEP -------------------------------------GHSAKKDSGIDHEE--------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------DYSYEGSKEIESK---------KV PDPTPAPKTTTTTKTT-------------------------------------------- ------------------SAPS------------------------------SGVSDSVD RDPAPGRSRPGYVPGSTFPRR------P-------------------------------- ----------------------------------II------------------------ ---------------------------GSNGRL--------------------------- ----------------RSPLLTN-RQAGSRFPLRAQPAQN----------T--------- -QLSS-NNPD-------TTS---------------------------------------- ------------------------------------------------------------ ----SSSSS----------------------------LSQPDRGISTGASVS-------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------AGGS----------------------- ----GMRTRNPSRLDP-FKGRTPSGGLKPSY------G------D--------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------GKNGRPNLTAT-------- --SEK-DSRTSNDNTKANGQRHITGPDGATWVVDLDRGFLMNENGRILQDSQGRPRRVVL GEDGRTIFDHQGSPLVNQDGQTLFGHGRESQPVVNPKDK-FLTLGGKPVIGLD--RPKPR T--T-TT----------------------------------P--PT-------------- --------TT-----------IP------------------------------------- --------------------------------------------------------P-TT ----------TTPEP---------TTLPTTTEMT--------TEE------------STT MVFPTCPPETFMMRDDRGFPIM-DANGVMDCY--------------------------P- -------------------------------------------------------EN--- ---------------------E--------LV-WQ-TTLPSTTSSTL-----P---P--- -------MTTTP------------------------------------------TTTT-- TA----------PPTPEPEARS----------------------F--------------- -----NNSPSNEFDLTGKKRFT--------------------------APYVNFIKKDPG APCSLTEALEYLQVDILESLMSKDSLTSNQKQPPKNKPHNITVVAMEGCHSFVILDWAIP LKDDMVSGYMVHSASYDDVLNNRWSSSTSSGTHLAVENLKPNS----------------- -------------RYYFKVQAKNVFGLGPLSDTLTYVTESDDPLLIERPPD--------- ------GEPIWIPFSFRYNPQHSACKGSQFVKRTWYRKFVGVVLCNSLRYKIFMGDGL-K -DIFYSIADSFGNGEDHCQFVDSYLDGRTGSPNLSTFLPTAQGYYRSYRQEPVSFGPIGR RTPHLFVGWYECGVPIPGKW---------------------------------------- ------------------------------------------------------ >ENSOMEP00000025741 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------------M--------- ------------------------------------------------------------ ----------------------------------------------------LCVLTLNS RFPQTRNISLLLIFSTISAEKLPRSQNGKQTSLDEILREIWEPPIHLDGRPV----DRFF ------------------------------------------------------TSSSSK P-----------------------------------------------TR---------- -----------LHRFSKVSKDSRAHLLEDL--------------------------DP-- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------DWVDLDGFAVLGNAP------------ ------------------VRNSSA------------------------------------ ------------------------------------------------------------ --------------------GS-------------------------------------- ------------------VRSSQTGV-RNYS-TAGRNAKVDRTARPAGGTS--------- -----------ALIKR---------RAPQSSSGPRQ-------PD-RSAS-----GAPM- -LHKRRQHNTKRQAEQINRYRTKP----------------SESV---------------- ---------HMVSLQAQT-----------------AQGLRAPPIRAAAVK-SIPEP---- ---PIN-EARDINVRVMSPKSVLISWVDPAVE-MGK-VSPEAS-RSYTVRFREKGESARW EYRESSQRRVMIETLSADGMYEFSIRISEGEKHSEWSASVFQRTPESAPSGPPENFEVKP LRGKGTVVTATWDPPEEPNGRIREYILSYAPAMKPFGMKSLTYSGSTTTATIDGLTPGER YIFKIRATNKRGMGPQSKAFSVAMPK-----------S-SSGASSSS---------KTK- ------------HSQQT------------------------------------------- --------------VDS---EDK------------------------------------- --------------------------------------------------SSVRS----T EVP--P----------------ATTPQ------------------------------IR- ----------PAGRRLRPLSQTRSYHSIFSSIRGSVRHVSN-----------RGKA---- -----------------------------------KDDEV-------------------- ------------------------------------------------------------ --------ED-------------------------------KITPTPP------STEE-- --------------------------------------TTTVTVVPETKK---------- -----------------------------------IDN---------------------- ----------------------NV------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------DS----- ------------------------------------------------------------ --------------VSEEKLEYDEEPKTTNPPSLKVLTP--------------------- ----------------------------------------SPTKPVHR------------ ------------------------------------------------------------ ---------------------------------NAFRPN--------------------- ------------------------------------------------------------ -------------------------------R---------------------------- ---------------------------------------------------RP------V KIRVH--------------------------------------------------QKSG- ------------------------SKIVS------------------------------- ----------------------------------------------------------SS SNK----------DSSV-KSLDSSSSAKSSS----------------------------- -------------------------------ISLNSSSSLP-SLSMSL------------ ----------------------SS------------------------------------ -----------------------------SVSSS-------------------------- ------------------------------------------------------------ ----------SSQIQNPEARREANVAATYPH-----------------SPNIYSKTNRTE SK---------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------------PSTAIL--- N----------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------G------ ----------ANSQKINI----RGS----------------------------------- -----LAGRSS-------------------------------------------SSSGLG --------------------------------------VR-------------------- --------------FGR-----------------------------------KHPRLFVK GNSSQISQSYKPA----------------------------------------------- -A------ATRQSLNPQSTSKTESASPERADNQ-------ETQNTFNPKASQTTLKS--- -----------------------------------------------SPDILAAIDSSV- ------------------------------------------------------------ ------------------------------------------------------------ FDKSQLT----------------------------------------------------- ------------IDSG-------------------------------------------- ---------------------------L-------------------------------- --------------------------HGS------------------------------- --------------------------------------------------------TAIQ DNKPSTS----------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------GSFLSTAQGVSPN SATL---HILQGSQKSTNQDTTYREATHLTPDNDPNKAEVTKLEEPSFGSERQVIETGK- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------R-GDKSGNGKRVHSRTR LSPTFAERFPWLASRYPG---------RFDS----------------------KSRG--- ---------------------------------------SL---PRQSSRAP-------- ------------------------------------------------------LTRVS- ------------------------------------------------------------ ------------------------------------------------------------ ----SSV----------------------------------------------------- -------------------GAG---------------------------RPLLTGTPTRL -------------------SGAAG----SSIQETKEDLRISPAQDTLSNTAG-------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------------S S--------------------------------------------------LVQSNQNVA SDT---------------------------RKPLISVSPSAS------------------ ------------------------------------------------------------ ------------------------------------------DSD-SHHFLSGKRPSSE- ------------------------------------------------HT---------- ---------NIKEKLENHLLVRSGEDGNDLAESYKD--------------------STIT SISERTANNRDNVGR--------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------REALSRTNPSLSSRVIQ--- -----------------SPRR------P-------------------------------- ------------------------------------------------------------ -------------------------GVGMTGNG--------------------------- ----------------RSSHLNTRQFGGSRLPIRPHAAQN----------S--------- -RLDA-SSPESV-----DFS-----------------SSNIPLPD--------------- ------------------------------------------------------------ -------------------------------------------------LTSDRNVGGSA TVTKTGGL------------------------MEDNSQTSSRDSSR------NHGS---- ---------------RRRYPV-----IRG------------KP----------------- --------N--------------------------------------------------- ------------------------------G------G------N--------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------GRNGRLNLTAS-------- --NEK-DSLTSLGSSKIPSQKFITGPDGTKWMIDFERGFLMNQDGQVLQDSQGRPKRVVL GEDGRTIFDHMGSPLLNQEGLALFGHGRDSQPVVNPKNK-LLMVGGKPVLGLD--VFHPK SF-S-TI----------------------------------T--TT-------------- ------------------------------------------------------------ ------------------------------------------------------TAR--P ----------TTQEP-------------TTTEWS--------SEE-----------FSTT LPFPTCPPGTFSKTDEFGYPLL-DQEGILDCY--------------------------P- ------------------------EEDA-SGMETDDLLSV---SMVP--DALALEKD--- ---------------------E--------LL-VK-TTS-------V-----P------- -------------------------------------------------------TTT-- RTTTE-------TPTPEPN-RP----------------------M--------------- -----NRGPSSAFDLSGKERFT--------------------------APYVNYIRKDPG APCSLTEALEFLQVDVLADLMKKDHQAASQKEPPKHKPHNLTVVAMEGCHSFIILDWARP LKGDMVSGYMVYSASYDDVLKNKWSSRLSNGTHLPVENLKPNS----------------- -------------RYYFKVQAKNVFGLGPVSETLTYVTESDDPLLIERPPG--------- ------GEPIWIPFTFKYNPAHSSCKGSQYVKRTWYRKFVGVVLCNSLRYKIFMGDGL-R -DLFHSIGDTVGQGEDHCQFVDSYRDGRTGPISY--HLPSAQGYYRAYRQEPVKFGAIGP RSPHSIVGWYECGVPIPGKW---------------------------------------- ------------------------------------------------------ >ENSORLP00000026561 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------------MV-------- ---LAASRT---------------LLVLFLTFCAPGC----------------------- ------------------------G---------------------WTADKLL------- -----------------------RPQNGKQTSLDEVLRDIWEPSIHLDGRPV----DRFF ------------------------------------------------------T-SSSK P-----------------------------------------------TR---------- -----------LHRFSKVSRDSRAHLLEDL--------------------------DP-- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------DWVDLDGFAVLGNAP------------ ------------------VRNSSA------------------------------------ ------------------------------------------------------------ --------------------GS-------------------------------------- ------------------VRSSQTGV-RNYS-SAGRNAKLDRTARLGGGTS--------- -----------SVIQR---------RAPQSSSGPRQ-------PE-RAAA-----GAPM- -LEHRRQHN------------TKPQADQRNRRRPKL---TSESV---------------- ---------HVVSLQAQT-----------------AQGQRAPPNRAVAVK-TTPEP---- ---PIN-EARDINVRVMSPKSVLISWVDPAVE-MGK-VAPEAS-RSYTVRFREKGESARW EYQESSQRRVMIETLSADGMYEFSVRISEGEKHSTWSASVFQRTPESAPSGPPENFEVKP LRGKGTVVTATWDPPEEPNGRIREYILSYAPAMKPFGMKSITYSGSTTTATVDGLTPGER YIFKIRATNRKGMGPQSKTFSVAMPQ-----------S-SSGASSSS---------KAKL ------------HSQQT------------------------------------------- --------------ISS---GAK------------------------------------- --------------------------------------------------SRIQS----T EVP--P----------------ATTPQ------------------------------LH- ----------PASRRLRPLSQTRSYHSVFSALRGSFRHVSN-----------RVKA---- -----------------------------------RDDEVEE------------------ ------------------------------------------------------------ --------ED-------------------------------KITPTTP------SIEE-- --------------------------------------TTTVEIIPETKK---------- -----------------------------------IDN---------------------- ----------------------NV------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------DP----- ------------------------------------------------------------ --------------VSDEKLGYDDEPKPTNPPSLKVLTP--------------------- ----------------------------------------SPTKPVHK------------ ------------------------------------------------------------ ---------------------------------NAFRPN--------------------- ------------------------------------------------------------ -------------------------------R---------------------------- ---------------------------------------------------RP------V KIRVH--------------------------------------------------QKSG- ------------------------SKMISS----PSSPKDSFVATADSA----------- -------------------------------------------------STFSAKSSISS S----------------------------------------------------------- --------------------------------SLNSSSSLP-SLSMSLPS--------SA S--------------------SSS------------------------------------ -----------------------------SASSS-------------------------- ------------------------------------------------------------ ----------SSHIQNPEANRKVNVAATYPH-----------------SPKIYIKSNRTE AK---------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------------PSTAIL--- N----------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------G------ ----------ANSPKINILTTGRGS----------------------------------- -----LAGR-N-------------------------------------------SSSGFG --------------------------------------VR-------------------- --------------FGR-----------------------------------KHPGLFVK GNSFQISRSYQPAVASHLNL-------PSRQASNSKSPS-----------KTLSASQEGA E------------------------------NQ-------ETQNVFNPKASQTTLTS--- -----------------------------------------------ITDILATLDTNV- ------------------------------------------------------------ ------------------------------------------------------------ FDKPQLTTGTAVRGSTARQGIKPFDSGSIFS----------------------------- ----------AP------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------QGVSPN SATLNANQILQGSKDSTDQDTTYKQTTYLTTDKNPNEAEVTKLDEPSVGSERETIETGK- ------------------------------------------------------------ ------------------------------------------------------------ ----------RE------------------------------------------------ -----------------------------------------EER-GHQSRNGKRVHSRNR LNPSFAERSPWQASQYPG---------RFNS----------------------RSRA--- ---------------------------------------SL---PRKSSRMP-------- ------------------------------------------------------ITHVS- ------------------------------------------------------------ ------------------------------------------------------------ ----SSV----------------------------------------------------- -------------------GAG---------------------------KPLLTETQTRL -------------------SGAAG----SSIQETKEDLRISPGHDTQKNRLG-------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------------S S--------------------------------------------------LVQSNQNTT SDT---------------------------KKALTSVYPSAST----------------- ------------------------------------------------------------ ----------------------------------------KLNSD-SLHFLSAKRPSSE- ------------------------------------------------HTEKEIIKKKTH NHNGDQLQE------------RSGEDGNDLAESYEDPAITFVSEGNAKNGENADRG---- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------EALSRTKPSLFSRVSQ--- -----------------SPRR------S-------------------------------- ------------------------------------------------------------ -------------------------GVRITGNE--------------------------- ----------------RSSHLNTGLFAGSRLPIRPHAAQN----------S--------- -RLDG-SSPESA-----DFS-----------------SSNLPLPD--------------- ------------------------------------------------------------ -------------------------------------------------PSSARNVGGSA TITRTGGLTGSNSQSS------MSSSLLRNSF-------------R------NHGS---- ---------------RRRLPT-----INR------------KP----------------- --------N--------------------------------------------------- ------------------------------G------G------N--------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------GRNGQLNLTAS-------- --IQK-DSLTSLGSSKAASQKSIIGPDGTKWMIDFERGVLMNQDGQVLQDSQGKPKRVVL GEDGRTIFDHMGSPLLNQEGLALFGHGRGSQPVVNPKDK-VLMVGGKPVLGLD--VFRPR SFSS-TT----------------------------------T--TT-------------- ------------------------------------------------------------ ------------------------------------------------------TAL--P ----------TTAAP-------------TTTEWS--------SEE-----------FTTA LPFPTCPPGTFSKTDEFGYPLL-DQEGILDCY--------------------------P- ------------------------EEDA-SGMELDHMLTV---SMLP--DALALEKD--- ---------------------E--------IF-VQ-TTL-------V-----P---T--- -------------------------------------------------------TTT-- RTTTE-------IPTPEPN-RP----------------------I--------------- -----NRGPSAAFDLSGKKRFT--------------------------APYVNYIRKDPG APCSLTEALEFLQVDVLEDLMKKDRQAASQGEAPKHKPHNLTVVAMEGCHSFIILDWARP LKGDMVSGYMVYSASYDDVIKNKWSSRLSNGTHLPVENLKPNS----------------- -------------RYYFKVQAKNVFGLGPVSETLTYVTESDDPLLIERPPG--------- ------GEPIWIPFTFKYNPGHSSCKGSQYVKRTWYRKFVGVVLCNSLRYKIFMGDGL-R -ELFHSIGDTVGQGEDHCQFVDSYRDGRTGPISVLNNLPSTQGYYRAYRQEPVKFGAIGP RTPHSVVGWYECGVPIPGKW---------------------------------------- ------------------------------------------------------ >ENSORLP00020012025 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------------MV-------- ---LAASRT---------------LLVLFLTFCAPGC----------------------- ------------------------G---------------------WTADKLL------- -----------------------RPQNGKQTSLDEVLRDIWEPSIHLDGRPV----DRFF ------------------------------------------------------T-SSSK P-----------------------------------------------TR---------- -----------LHRFSKVSRDSRAHLLEDL--------------------------DP-- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------DWVDLDGFAVLGNAP------------ ------------------VRNSSA------------------------------------ ------------------------------------------------------------ --------------------GS-------------------------------------- ------------------VRSSQTGV-RNYS-SAGRNAKLDRTARLGGGTS--------- -----------SVIQR---------RAPQSSSGPRQ-------PE-RAAA-----GAPM- -LEHRRQHN------------TKPQADQRNPRRTKL---TSESV---------------- ---------HVVSLQAQT-----------------AQGQRAPPNRAVAVK-TTPEP---- ---PIN-EARDINVRVMSPKSVLISWVDPAVE-MGK-VAPEAS-RSYTVRFREKGESARW EYQESSQRRVMIETLSADGMYEFSVRISEGEKHSTWSASVFQRTPESAPSGPPENFEVKP LRGKGTVVTATWDPPEEPNGRIREYILSYAPAMKPFGMKSITYSGSTTTATVDGLTPGER YIFKIRATNRKGMGPQSKTFSVAMPQ-----------S-SSGASSSS---------KAKL ------------HSQQF------------------------------------------- --------------ISS---GAK------------------------------------- --------------------------------------------------SRIQS----T EVP--P----------------ATTPQ------------------------------LH- ----------PASRRLRPLSQTRSYHSVFSALRGSFRHVSN-----------RVKA---- -----------------------------------RDDEVEE------------------ ------------------------------------------------------------ --------ED-------------------------------KITPTTP------SIEE-- --------------------------------------TTTVEIIPETKK---------- -----------------------------------IDN---------------------- ----------------------DV------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------DP----- ------------------------------------------------------------ --------------VSDEKLGYDEEPKPTNPPSLKVLTP--------------------- ----------------------------------------SPTKPVHK------------ ------------------------------------------------------------ ---------------------------------NAFRPN--------------------- ------------------------------------------------------------ -------------------------------R---------------------------- ---------------------------------------------------RP------V KIRVH--------------------------------------------------QKSG- ------------------------SKMISS----SSSPKYSHVATSDSA----------- -------------------------------------------------STFSAKSSISS S----------------------------------------------------------- --------------------------------SLNSSSSLP-SLSMSLPS--------SA S--------------------SSS------------------------------------ -----------------------------SASSS-------------------------- ------------------------------------------------------------ ----------SSHIQNPEANRKVNVAATYPH-----------------SPKIYIKSNRTE AK---------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------------PSTAIL--- N----------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------G------ ----------ANSPKINILTTGRGS----------------------------------- -----LAGR-N-------------------------------------------SSSGFG --------------------------------------VR-------------------- --------------FGR-----------------------------------KHPVLFVK GNSFQISRSYQPAVASHLNL-------PSRQASNSKSPS-----------KTLSASQEGA E------------------------------NQ-------ETQNVFNPKASQTTLTS--- -----------------------------------------------STDILATLDTNV- ------------------------------------------------------------ ------------------------------------------------------------ FDKPQLTTGTAVRGSTARQGIKPFDSGSIFS----------------------------- ----------AP------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------QGVSPN SATLNANQILQGSQNSTDQDTTYKQTTYFTTDKNPNEAEVTKLDEPSVGSERETIETGK- ------------------------------------------------------------ ------------------------------------------------------------ ----------RE------------------------------------------------ -----------------------------------------DER-GYQTRNGKRVHSRNR LNPSFAERSPWQASQYPG---------RFNS----------------------RSRA--- ---------------------------------------SL---PRKSSRMP-------- ------------------------------------------------------ITQVS- ------------------------------------------------------------ ------------------------------------------------------------ ----SSV----------------------------------------------------- -------------------GAG---------------------------KPLLTETQTRL -------------------SGAAG----SSIQETKEDLRISPGHDTQKNRLG-------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------------S S--------------------------------------------------LVQSNQNTT SDT---------------------------KKALTSVYPSAST----------------- ------------------------------------------------------------ ----------------------------------------KLNSD-SLHFLSGKRPSSE- ------------------------------------------------HTEKEIIKKKTH NHNGDQLQE------------RSGEDGNDLAESYEDPAITFVSEGNAKNGENADRG---- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------EALSRTKPSLFSRVSQ--- -----------------SPRR------S-------------------------------- ------------------------------------------------------------ -------------------------GVRITGNE--------------------------- ----------------RSSHLNTGLFAGSRLPIRPHAAQN----------S--------- -RLDG-SSPESA-----DFS-----------------SSNLPLPD--------------- ------------------------------------------------------------ -------------------------------------------------PSSDRNVGGSA TITRTGGLTGSNSQSS------MSSSLLRNSF-------------R------NHGS---- ---------------RRRLPT-----INR------------KP----------------- --------N--------------------------------------------------- ------------------------------G------G------N--------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------GRNGQLNLTAS-------- --IQK-DSLTSLGSSKAASQKSIIGPDGNKWMIDFERGVLMNQDGQVLQDSQGKPKRVVL GEDGRTIFDHMGSPLLNQEGLALFGHGRGSQPVVNPKDK-VLMVGGKPVLGLD--VFRPR SFSS-TT----------------------------------T--TT-------------- ------------------------------------------------------------ ------------------------------------------------------TAL--P ----------TTAAP-------------TTTEWS--------SEE-----------FTTA LPYPTCPPGTFSKTDEFGYPLL-DQEGILDCY--------------------------P- ------------------------EEDA-SGMEMDHMLTV---SMLP--DALALEKD--- ---------------------E--------IF-VQ-TTL-------V-----P---T--- -------------------------------------------------------TTT-- RTTTE-------IPTPEPN-RP----------------------I--------------- -----NRGPSAAFDLSGKKRFT--------------------------APYVNYIRKDPG APCSLTEALEFLQVDVLEDLMKKDRQAASQREAPKHKPHNLTVVAMEGCHSFIILDWARP LKGDMVSGYMVYSASYDDVIKNKWSSRLSNGTHLPVENLKPNS----------------- -------------RYYFKVQAKNVFGLGPVSETLTYVTESDDPLLIERPPG--------- ------GEPIWIPFTFKYNPGHSSCKGSQYVKRTWYRKFVGVVLCNSLRYKIFMGDGL-R -ELFHSIGDTVGQGEDHCQFVDSYRDGRTGPISVFSNLPSTQGYYRAYRQEPVKFGAIGP RTPHSVVGWYECGVPIPGKW---------------------------------------- ------------------------------------------------------ >ENSMAMP00000010630 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------------MA-------- ---LAASRT---------------LLALFVTFCAPEC----------------------- ------------------------G---------------------WTAEKPL------- -----------------------RPPNGKQTSVDKGLRDSWEPSIHLDGRPV----DRFF ------------------------------------------------------I-SSNK P-----------------------------------------------TR---------- -----------SHRFTKVGKDSHSHQLEEV--------------------------DP-- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------EWVNLDGFAVLGGAP------------ ------------------VSNSSAG----------------------------------- ------------------------------------------------------------ ---------------------P-------------------------------------- ------------------ARSSEIPA-RNQP-TIQRATRLDRTAHSSGMSN--------- -----------TRTHR---------RAPQSSSGPRQ-------PE-RALA-----GTPL- -LERR--HH------------TKPQSDQRNRNTPKL---TSESV---------------- ---------HVVSLQAQK-----------------ALGQSAPVSRAVTIKTTTPEP---- ---PEY-EAQDISVRVTSPQSVLISWVDPAVE-MGK-VAPGAS-RSYTVRYREKGESARW EYKESTQKRLMIDTLSADSMYEFSVRISQGENHGKWSVSVFQRTPESAPSGPPENFEVKP LRGKGTAVIATWDPPEDPNGRIREYILSYAPAMKPFGMKSLTYRGSTSTATIDGLTPGHR YIFKIRATNRRGQGPQTKAFSVAMPG-----------S-SSTASSFS---------KTK- ------------NTHKT------------------------------------------- --------------THT---PSKQDTDHD------------------------------- -------------------------------------------------EANLQS----T EAPEEQ----------------TTPPQ--------------------------------P --------ATPIKRRVRPLSQTRSYHSIFSSVRGSVRGSS------------RGSSR--- ------------------------------GRTPDREDVEEE------------------ ------------------------------------------------------------ --------EE-------------------------------RI--TPP------PEEE-- --------------------------------------TTTMEAVSEKKE---------- -----------------------------------PDN---------------------- ----------------------DV------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------SP----- ------------------------------------------------------------ --------------EPEDEVGYEEEPLTTETPSPKILTL--------------------- ----------------------------------------SPTKLASA------------ ------------------------------------------------------------ ---------------------------------KHNASP--------------------- ------------------------------------------------------------ -------------------------------K---------------------------- ---------------------------------------------------RP------I RIRVH--------------------------------------------------QNPK- ------------------------SKATS------------------------------- ----------------------------------------------------------ST S------------------STSSSSSASSSS----------------------------- -----SSDS--------------------------SSS----------SI--------SS S--------------------PSS------------------------------------ -----------------------------TSLNS-------------------------- ------------------------------------------------------------ ----------SPHTQESAASKKDYIASTYPE-----------------SKNIYDKSSIT- QK---------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------------PSTSVVKET E---------------------------------KSQQTEVTA----------------- ---------------------------------AGRGLASTG------------------ ---------------------------------------RAS------------------ ------------------------------------------------------------ -----------------------------------------------------G------ ------------------------------------------------------------ --------------------------------------------------------SGFG --------------------------------------SR-------------------- ------------YGFGR-----------------------------------RHPGMLFR GNLTRTLNGYKPAVISESNL-------PSK------------------------------ -T-------------------------------------------------------LSH STTN------THNSA-----------------------TSTLANQGSS----HTLNSSTS R----------------------------------------------STTRGASNSQAT- -------------------------------------------------------SNTFS FDKSQST----------------------------------------------------- ------------SEPR-------------------------------------------- ---------------------------S-------------------------------- --------------------------HGS-------------TP-SHN------------ --------------------------------------------------------SG-- -TNPSTSQSSPQHTSTSD------------------------------------------ ------------------------TS---------------------------------- -----SSSQSTS-----------------HRGSHSSTSSHLKHDSQSSHTSSEQDETYTN RNDDNKNKNTDAE----------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------EPTSS--------------------------------- ------------------------------SKTQTTGEETREER-REESTNGNPVVSRTR ISSSFAEKFPWLASRYPG---------KFSS----------------------GPRV--- ---------------------------------------AS---SRQDGRNT-------- ------------------------------------------------------WPRTS- ------------------------------------------------------------ ------------------------------------------------------------ ----SSV----------------------------------------------------- -------------------GAS---------------------------RPSSVATPNKV -------------------SGATGTTAVSSIQEPSEELKTPSTHDSQKNRVGVSSGNPSL TNQNTPSSDT-NP------------------------STSSSSSPASSASTSTSSPRSSS ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------GHKDSDEP VRR-----------------GTSNNNNN-------------------DHS---------- ------------------------------------------------------------ --------------KGYVDERGSENSGKDDKIAGHSVVQKASAITTTEL----------- ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------HKNTENKQNADTKETPSRTRPGIFSGVTP--- -----------------THRR------P-------------------------------- ------------------------------------------------------------ -------------------------SVGVNGRV--------------------------- ----------------RSPVLANRQFGGSRVPIRPQPAQN----------S--------- -RLGS-STSDSSSSPTDSSS-----------------SSHLPRPV--------------- ------------------------------------------------------------ -------------------------------------------------LTSNRDAGTGS TVTKTGGLTEGSSQST--SSSSSSSS-------------SSRDSIR------NQGG---- ---------------RSRYPI-----LGG------------KP----------------- --------TN-------------------------------------------------- -----------------------GGTVKVAN------G------N--------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------GKNGRPNLTAT-------- --NDK-ESSSSHGTSKAVGQRFITGPDGTKWVVDLEQGLLMNEDGQVLQDSQGKPKRVVL GEDGRTIFDHMGSPLVNQEGIALFGHGRDSRPVVNPKDK-VLLVGGKPVLGLD--LPHLR T--T-TT----------------------------------T--TT-------------- --------T--------------------------------------------------- -----------------------------------------------------------T ----------TTPEP-------------TTTEWT--------TEE-----------STTA LSHPTCPPGTFAKKDEYGYSVL-DSEGILNCY--------------------------P- ------------------------E-------------------------------D--- ---------------------E--------FF-VQTTTM-------P-----P---T--- -------TTTTT-------------------------------------------TTT-- TTTTTTSTTTTKIPTPEPQTRP----------------------F--------------- -----NKDPSSEFDLSGKKRFT--------------------------APYVNYIQKDPG APCSLTEALEYLQVDILEDLMRNDSFTATQNQPPKNKPHNLTVVAMEGCHSFIILDWAQP LKGDMVSGYMVHSASYDDVLNNRWSSRSSSGTHLPVENLKPNS----------------- -------------RYYFKVQAKNVFGLGPFSDTLTYVTESDDPLLIERPPG--------- ------GEPIWIPFTFKYNPTHSSCKGSQYVKRTWYRKFVGVVLCNSLRYKIFMGDGL-R -EPFYSIGDTFGQGEDHCQFVDSYRNGRTGPAYLSNHLPSAQGFYRAYRQEPVTFGVIGR RTAHPFVGWYECGVPIPGKW---------------------------------------- ------------------------------------------------------ >ENSSDUP00000027691 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------------MA-------- ---LAASRT---------------LLALFVTFCAPGC----------------------- ------------------------G---------------------WTAEKPL------- -----------------------RTHNGKQTSVDRGLRESWEPSIHLDGRPV----DRFV ------------------------------------------------------I-SSNK P-----------------------------------------------TR---------- -----------SHRLTKAGKDSRPHLMEDV--------------------------DP-- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------EWVNLDGFAVLGGAP------------ ------------------VTNSSAA----------------------------------- ------------------------------------------------------------ -------------------TDP-------------------------------------- ------------------VRSSQTAT-RNQP-SVQRATRVDRTAHPSGVSN--------- -----------TRTHR---------RAPQSSSGPRQ-------PE-RALA-----GTPL- -LERRRQHH------------TKPQSDQRNRNTAKL---TSESV---------------- ---------HVVSLQAQK-----------------AQGQSAPANRAVVTKTTTPEP---- ---PEY-EARDISVRVMSPQSVLISWVDPAVE-MGK-VAPGAS-RSYAVRYREKGESARW EYKDSTQRRMMIDTLSADGMYEFSVRISQGENHGKWSVSVFQRTPESAPSGPPENFEVKP LRGKGTAVVATWDPPEEPNGRIREYILSYAPAMKPFGMKSVTHRGSSNTATVDGLTPGDR YIFKIRATNRRGQGPQSKAFSVAMPG-----------S-ISTASSFS---------KTK- ------------DTRRT------------------------------------------- --------------GHT---PSKQDTDHD------------------------------- -------------------------------------------------ESDLLS----T EEPDTP-------------------PQ------------------------------PRP --------AASVNRHVRPLSQTRSYHSIFSSVRGSVRNTAN-----------RGSSR--- ------------------------------GRTQDREDEEQD------------------ ------------------------------------------------------------ --------EE-------------------------------QIPTTPP------PVEE-- --------------------------------------TTTMEVVPETEE---------- -----------------------------------PDN---------------------- ----------------------DV------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------SP----- ------------------------------------------------------------ --------------ESEDEEGYGEEPQTTETPSLKVLTP--------------------- ----------------------------------------SPAKP--A------------ ------------------------------------------------------------ ---------------------------------RP---A--------------------- ------------------------------------------------------------ -------------------------------R---------------------------- ---------------------------------------------------RP------I KIRVH--------------------------------------------------QKPG- ------------------------SKAAS------------------------------- ----------------------------------------------------------SS S------------------SSSSSSSSSS----------------STSSSSSS------- --SSPSSDS--------------------------SSSSSP-STS-SSSS--------SS S--------------------PSS------------------------------------ -----------------------------TSSSS-------------------------- ------------------------------------------------------------ ----------SSHIQESAVSRKDNVASLYPE-----------------NKDTYDKVSITH SK---------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------------PSTPVV--- -------------------------------------------IKTDSPQSG-------- ------------------------------ATPVGRGSASGG------------------ ---------------------------------------RTS------------------ ------------------------------------------------------------ -----------------------------------------------------G------ ------------------------------------------------------------ --------------------------------------------------------SGFG --------------------------------------SR-------------------- ------------YGYSR-----------------------------------RHPGILVR GNSTRMLNGYKPAITSQSNL-------PSR------------------------------ -T------PNQATTNTRSSATSQSTVPDRTQNH-------ETSHTFNPTASKSTSGS--- ------------------------------------------------------------ ----------------------------------------------------ASNGQAT- -------------------------------------------------------SGTYN FDKSQTR----------------------------------------------------- ------------SQSR-------------------------------------------- ---------------------------S-------------------------------- --------------------------HGSA------------TSDTHS------------ --------------------------------------------------------SS-- -ANPSTSQSSSQHPSTAG------------------------------------------ -------------------------S---------------------------------- -----GSSQSTS-----------------HGGSHSSATSHNTHNSESSHTSPERDTAYGE GGDANRNKNTDTE----------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------TSEVEEPTSS--------------------------------- ------------------------------SIRQPTEEQGREEEGREERTNVNPGGSRTR ISSSFAERFPWLASRYPG---------RFNS----------------------GTRT--- ---------------------------------------SS---SRQDGRTP-------- ------------------------------------------------------WTRTS- ------------------------------------------------------------ ------------------------------------------------------------ ----SSI----------------------------------------------------- -------------------GAG---------------------------RPIMRGTSTRV -------------------SGATGAAGVSSLQETSEDLKTPSTHDSLKNGVGVGSVKPSV TDKSTAPIDTRNP------------------------TTSSSSSSSSS---------SAS ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------------S S--------------------------------------------------A-------- -----------------------------------------ST----------------- ------------------------------------------------------------ ------------------------------------------YPN-SHHSSGGHRDSSEP IHR-----------------GTS------------------------------------- ------------------------------------------------------------ ------------------------------------------------DDTDSSH----- ----------------------------------GKDYDDERSREN----------RGKV ADPTVA------------------------------------------------------ -----------------QKNPAVTSADPDRNAEDNESVDTRETPSRTRTGTSFGITP--- -----------------THRR------P-------------------------------- ------------------------------------------------------------ -------------------------GVGVNGRV--------------------------- ----------------RSPLLASRQFGGSRLPIRPQPAQN----------S--------- -RLGS-STSGSSSSSSDSSS-----------------SSN-------------------- ------------------------------------------------------------ -----------------SPQT---------------------------ALTSGREAGTGT TVTRTGGIIGGNSPST-SSSSSSSSS-------------SSRDSFR------GQGG---- ---------------RPRYPI-----SRG------------KP----------------- --------TN-------------------------------------------------- -----------------------GGAVKPAN------G------N--------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------GKNGRPNLTAT-------- --DDK-DSSSSQGISKAVGQRFITGPDGTKWVVDLEQGVLMNQDGQVLQDSNGKPKRVVL GEDGRTIFDHMGSPLVNQEGMALFGHGRDSRPVINPKDK-VLMVGGKPVLGLD--LPHLR T--S-TT----------------------------------T--TT-------------- --------T------------TTT------------------------------------ --------------------------------TTT------------------TMAP--T ----------TTPEP-------------TTTEW---------PEE-----------TSTA LPFPTCPPGTFSKTDEYGYPVL-DPEGILDCY--------------------------P- ------------------------EEES-SGMEMDHMVTV---TMVP--DALALKKD--- ---------------------E--------LF-VQ-TTL-------P-----P---T--- -------TTTTT-------------------------------------------TTT-- TTTTATTPTTTEMATPPPRARP----------------------M--------------- -----NQGPSSEFDLSGKKRFT--------------------------APYVNYIRKDPG APCSLTEALEYLQVDVLEDLMKKDSVAASQRQPPKNKPHNFTIVAMEGCHSFIILDWARP LKGDMVSGYMVHSASYDDVLNNRWSSRASSGTHLPVENLKPNS----------------- -------------RYYFKVQAKNVFGLGPVSDTLTYVTESDDPLLIERPPG--------- ------GEPIWIPFTFKYNSAHSSCKGSQYVKRTWYKKFVGVVLCNSLRYKIFMGDGL-R -EPFYSIGDTFGQGEDHCQFVDSYRDGRTGPAYLSNNLPTAQGFYRAYRQEPVTFGVIGR RTSHPFVGWYECGVPIPGKW---------------------------------------- ------------------------------------------------------ >ENSSLDP00000006434 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------------MA-------- ---LAASRT---------------LLALFVTFCAPGC----------------------- ------------------------G---------------------WTAEKPL------- -----------------------RTHNGKQTSVDRGLRESWEPSIHLDGRPV----DRFV ------------------------------------------------------I-SSNK P-----------------------------------------------TR---------- -----------SHRLTKAGKDSRPHLMEDV--------------------------DP-- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------EWVNLDGFAVLGGAP------------ ------------------VTNSSAA----------------------------------- ------------------------------------------------------------ -------------------TDP-------------------------------------- ------------------VRSSQTAA-RNQP-SVQRATRVDRTAHPSGVSN--------- -----------TRTHR---------RAPQSSSGPRQ-------PE-RALA-----GTPL- -LERRRQHH------------TKPQSDQRNRNTAKL---TSESV---------------- ---------HVVSLQAQK-----------------AQGQSAPANRAVVTKTTTPEP---- ---PEY-EARDISVRVMSPQSVLISWVDPAVE-MGK-VAPGAS-RSYAVRYREKGESARW EYKDSTQRRMMIDTLSADGMYEFSVRISQGENHGKWSVSVFQRTPESAPSGPPENFEVKP LRGKGTAVIATWDPPEEPNGRIREYILSYAPAMKPFGMKSVTHRGSSNTATVDGLTPGDR YIFKIRATNRRGQGPQSKAFSVAMPG-----------S-ISTASSFS---------KTK- ------------DTRRT------------------------------------------- --------------GHT---PSKQDTDHD------------------------------- -------------------------------------------------ESDLLS----T EEPDTP-------------------PQ------------------------------PRP --------AAPFNRPVRPLSQTRSYHSIFSSVRGSVRNTAN-----------RGSSR--- ------------------------------GRTQDREDEEQD------------------ ------------------------------------------------------------ --------EE---------------------------------PTTPP------PVEE-- --------------------------------------TTTMEVVPETEE---------- -----------------------------------PDN---------------------- ----------------------DV------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------SP----- ------------------------------------------------------------ --------------ESEDEEGYGEEPQTTETPSLKVLTP--------------------- ----------------------------------------SPTKP--A------------ ------------------------------------------------------------ ---------------------------------RP---A--------------------- ------------------------------------------------------------ -------------------------------R---------------------------- ---------------------------------------------------RP------I KIRVH--------------------------------------------------QKPG- ------------------------SKAAS------------------------------- ----------------------------------------------------------SS S------------------SSSSSSSSSSSSSSSSSTSSSSSPATSSSSSSSS------- --SSPSSDS--------------------------SSSSSP-ST----SS--------SS S--------------------PSS------------------------------------ -----------------------------TSSSS-------------------------- ------------------------------------------------------------ ----------SSHIQESAVSRKDNVASLYPE-----------------NKDTYDKASIAH SK---------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------------PSTPVV--- -------------------------------------------IKTDSPQSG-------- ------------------------------ATPVRRGSASGG------------------ ---------------------------------------RTS------------------ ------------------------------------------------------------ -----------------------------------------------------G------ ------------------------------------------------------------ --------------------------------------------------------SGFG --------------------------------------SR-------------------- ------------YGYSR-----------------------------------RHPGILVR GNSTRMLNGYKPAITSQSNL-------PSR------------------------------ -A------PNQAATNTRSSATSQSTVPDRTQNH-------ETLHTFNPTASKPTSGS--- ------------------------------------------------------------ ----------------------------------------------------ASNSQAT- -------------------------------------------------------SGTYN FDKSQSR----------------------------------------------------- ------------SQSR-------------------------------------------- ---------------------------S-------------------------------- --------------------------HGSA------------TPDTHS------------ --------------------------------------------------------SS-- -ANPSTSQSSSQHPSTAG------------------------------------------ -------------------------S---------------------------------- -----GSSQSTS-----------------QGGSHSSATSHNTHNSESSHTSPERDTAYGE GGDANRNKNTDTE----------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------TSEVEEPTSS--------------------------------- ------------------------------SKRQPTEEQGREEEGREERTNVNPGSSRTR ISSSFAERFPWLASRYPG---------RFNS----------------------GTRT--- ---------------------------------------SS---SRQDGRTP-------- ------------------------------------------------------WTRTS- ------------------------------------------------------------ ------------------------------------------------------------ ----SSV----------------------------------------------------- -------------------GAG---------------------------RPIMRGTSTRV -------------------SGATGAAGVSSLQETSEDLKTPSTHDSLKNGVGVGSVKPSV TDKSSASIDTRNP------------------------TTSSSSSSSSS---------SAS ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------------S S--------------------------------------------------A-------- -----------------------------------------ST----------------- ------------------------------------------------------------ ------------------------------------------YPN-SHHSSGGHRDSSEP IHR-----------------GTS------------------------------------- ------------------------------------------------------------ ------------------------------------------------DDTDSSH----- ----------------------------------GKDYDDERSREI----------SGKV ADPTVA------------------------------------------------------ -----------------QKNPAVTSADPDRNAEDNESVDTRETPSRTRTGTSFGITP--- -----------------THRR------P-------------------------------- ------------------------------------------------------------ -------------------------GVGVNGRV--------------------------- ----------------RSPLLASRQFGGSRLPIRPQPAQN----------S--------- -RLGS-STSGSSSSSSDSSS-----------------SSN-------------------- ------------------------------------------------------------ -----------------SPQT---------------------------ALTSDREAGTGT TVTRTGGIIGGNSPSTSSSSSSSSSS-------------SSRDSFR------GQGG---- ---------------RPRYPI-----SRG------------KP----------------- --------TN-------------------------------------------------- -----------------------GGAVKPAN------G------N--------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------GKNGRPNLTAT-------- --DDK-DSSSSQGISKAVGQRFITGPDGTKWVVDLEQGVLMNQDGQVLQDSNGKPKRVVL GEDGRTIFDHMGSPLVNQEGMALFGHGRDSRPVINPKDK-VLMVGGKPVLGLD--LPHLR T--S-TT----------------------------------T--TT-------------- --------TA-----------TTT------------------------------------ --------------------------------TTT------------------TMAP--T ----------TTPEP-------------TTTEW---------PEE-----------TSTA LPFPTCPPGTFSKTDEYGNPVL-DPEGILDCY--------------------------P- ------------------------EEES-SGMEMDHMVTV---TVVP--DALALKKD--- ---------------------E--------LF-VQ-TTL-------P-----P---T--- -------TTTTT-------------------------------------------TTT-- T----ATPTTTEMATPPPRARP----------------------M--------------- -----NQGPSSEFDLSGKKRFT--------------------------APYVNYIRKDPG APCSLTEALEYLQVDVLEDLMKKDSVAASQRQPPKNKPHNFTIVAMEGCHSFIILDWARP LKGDMVSGYMVHSASYDDVLNNRWSSRASSGTHLPVENLKPNS----------------- -------------RYYFKVQAKNVFGLGPVSDTLTYVTESDDPLLIERPPG--------- ------GEPIWIPFTFKYNSAHSSCKGSQYVKRTWYKKFVGVVLCNSLRYKIFMGDGL-R -EPFYSIGDTFGQGEDHCQFVDSYRDGRTGPAYLSSNLPTAQGFYRAYRQEPVTFGVIGR RTSHPFVGWYECGVPIPGKW---------------------------------------- ------------------------------------------------------ >ENSSMAP00000027876 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------------MA-------- ---LAASRT---------------LLALFVTFCAPGC----------------------- ------------------------G---------------------WTAEKPL------- -----------------------RPHNGKQTSVDKGLRESWEPSIHLDGRPV----DRFV ------------------------------------------------------I-SSSK P-----------------------------------------------TR---------- -----------SHRFTKAGKDIRSHLLEDV--------------------------DP-- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------EWVNLDGFAVLGGAP------------ ------------------VSNSSAA----------------------------------- ------------------------------------------------------------ -------------------TGP-------------------------------------- ------------------VRFSQTAG-RNQP-SVKRAARVNRTARPSGVSN--------- -----------TRTHR---------RAPQSSSGPRQ-------PE-GASV-----GTPL- -LARRHQHH------------TKPQSDQRNR---KL---TSESV---------------- ---------HVVSLQAQK-----------------PPGQSAYGKRGVATKTTTPEP---- ---PEY-EARDISVRVMSPQSVLITWLDPAVE-MGK-VTNEAS-RSYTVRYREKGESARW EYKDSTQRRMMIETLSADGMYEFSVRISQGENHSKWSVSVFQRTPESAPSGPPENFEVKP LRGKGTAVIATWDPPEEPNGRIREYILSYAPAMKPFGMKSLTYRGSSTTATVDGLTPGDR YIFKIRATNRRGQGPQSKVFSVAMPG-----------S-SSTASAFS---------KTK- ------------DTQRT------------------------------------------- --------------SHT---PSKQDSDHD------------------------------- -------------------------------------------------KSDLSA----T EEPEEP----------------ITTPQ------------------------------PRP --------AAPVNRRQRPLSQTRSYHSIFSSVRGSARN------------------R--- ------------------------------GRVQDREDEEEV------------------ ------------------------------------------------------------ --------EE-------------------------------KIPTTPP------PVEE-- --------------------------------------TTTMEVVPETKE---------- -----------------------------------PDN---------------------- ----------------------DV------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------SP----- ------------------------------------------------------------ --------------KSEDEVGYDDEPLTTETPSLKVFIP--------------------- ----------------------------------------SPTKPASA------------ ------------------------------------------------------------ ---------------------------------RPKPLP--------------------- ------------------------------------------------------------ -------------------------------R---------------------------- ---------------------------------------------------KP------I KIRVH--------------------------------------------------SKAV- ------------------------SKTAS------------------------------- ----------------------------------------------------------SS ------------------------------------------------------------ -----SSDA--------------------------SSNSFP-STS-SLST--------SS S--------------------PSS------------------------------------ -----------------------------TSSSS-------------------------- ------------------------------------------------------------ ----------SSHIHESAASRKDYIASTYPE-----------------TKDSLDKAAVTY SK---------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------------PSIPVVKE- D---------------------------------SSQQSEAAA----------------- ---------------------------------VGRGSTSGG------------------ ---------------------------------------RLS------------------ ------------------------------------------------------------ -----------------------------------------------------G------ ------------------------------------------------------------ --------------------------------------------------------SGFG --------------------------------------SR-------------------- ------------YGYSR-----------------------------------RHPGIAFR GNSTRMLNGYKPAITSQSNL-------PSR------------------------------ -T------QSQATSDTR--ASSQSTVPERTHNH-------ETLHTLNPTASKATSGR--- ------------------------------------------------------------ ----------------------------------------------------ASNSQAT- -------------------------------------------------------SDTYN FDKSQTR----------------------------------------------------- ------------SQS--------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------GSNGFTTSNRQSLSTHTSTSQSSSQLPSN-------------- ----------------------AATS---------------------------------- -----GSSQST-----------------------------------TSHTSPERDTTYSD GNDDSENKNTDTEVTKVE------------------------------------------ ------------------------------------------------------------ ------------------------------VPASSSNAQPTEEENMEAE----------- ---------------------------------------------------------GKK ESI--------------------------------------------------------- ------------------------------------------------------------ -----------EKKPIV------------------------------------------- --------------------------------------------------------SRTR ISPSLAERFPWLTSRYPG---------RFHS----------------------GTRT--- ---------------------------------------SS---SRQDGRTP-------- ------------------------------------------------------WTRTS- ------------------------------------------------------------ ------------------------------------------------------------ ----SSV----------------------------------------------------- -------------------GAG---------------------------RPILRGTPTRV -------------------SGATGAAGVSTIQETSEDLRTPSTHDSLKNVVGAGSVKPSS TDKNVASSDTINP------------------------TTSSSSSSASS---------SSS HPSSGGNRDSIETVRKGT------------------------------------------ --------------------SNDNDNSPDKDFVDEGSREVSAGSDK-------------- ---------------------------VT-----------------------------DS ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---TVA------------------------------------------------------ -----------------QKNPAITSADPHRNTEDNESVDTRETSSRTRTGTSSGVIP--- -----------------THRR------P-------------------------------- ------------------------------------------------------------ -------------------------SVGANGRV--------------------------- ----------------RSPLLANRQFGGSRLPIRTQPAQN----------S--------- -RLDS-STSESSSSSSDSSS-----------------SSNLPQPMT-------------- PDREASTG-------TTVAKPGVIIGGNSE------------------------------ ----STSSSS-----SLSP----------------------------------------- -----------------------------------------RDSLR------GHGG---- ---------------RSRYPI-----TRG------------KP----------------- --------IN-------------------------------------------------- -----------------------GGVIKPAN------G------N--------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------GRNGRPNLTAT-------- --NDK-DSSDSHGTNKAVGQRFITGPDGSKWVVDLELGVLMNQDGQVLQDSHGKPKRVVL GEDGRTIFDHMGSPLLNQEGMALFGHGRESRPVVNPKEK-MLMVGGKPVLGLD--RPRLR P----------------------------------------------------------- ---------------------KTT------------------------------------ --------------------------------TTT------------------TMAP-TT ----------TTPEP-------------TTAEWT--------TEE-----------STTA MPYPTCPPGTFPKTDEDGYPLL-DIEGILDCF--------------------------P- ------------------------EEES-SGLEMDYMVTV---TMVP--DALALEKD--- ---------------------G--------VL-VQ-TTL-------P-----P------- ------------------------------------------------------------ ---------------PPP---P----------------------TTTISSTTVEMSTAVV FTGPNNKGPSSEFDLSGKKRFT--------------------------APYVTYIQKDPG APCSLTEALEYLQVDVLEDLMKQDTPEANQNQPPKRKPQNFTVVAMEGCHSFIILDWGRP LKDDMVSGYMVHSASYDDVLSNRWSSRPSSGTHLAVENLKPNS----------------- -------------RYYFKVQAKNVFGLGPVSETLTYVTESDDPLLIERPPG--------- ------GEPIWIPFTFKYNSAHSSCKGSQYVKRTWYRKFVGVVLCNSLRYKIFMGDGL-R -EPFYSVGDTFGQGEDHCQFVDSYRDGRTGPAYLSNNLPSAQGFYRAYRQEPVTFGVIGR RTPHPFVGWYECGVPIPGKW---------------------------------------- ------------------------------------------------------ >ENSMZEP00005024221 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------------MA-------- ---LATGRT---------------LVALFLTLCGPGC----------------------- ------------------------S---------------------WAAEKLP------- -----------------------RPQNVKPTSVEKGLRESWEPSIHLDGRPV----DRFM ------------------------------------------------------I-SSSK P-----------------------------------------------TR---------- -----------SHRFTKASKDSRAPMLEDV--------------------------DP-- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------EWVNLDGFAVLGGAP------------ ------------------VSNLSAA----------------------------------- ------------------------------------------------------------ --------------------GP-------------------------------------- ------------------VRSSQTVVPRNHS-SVKRATRMDRKAQLS--PN--------- -----------VRTHR---------RAPQSSSGPRQ-------PE-RVLA-----GVPL- -LERRRQHY------------AKPQSDQRNRLARKL---TSESV---------------- ---------HVVSLQAQK-----------------AQGQSKPANRPVTTKTTTPAP---- ---PEH-EAQDISVRVMSPKSVLISWVDPAVE-MEK-VAPGAS-RSYTVRYREKGESARW EYKESTQRRILIDTLSADSMYEFSVRISQEENHSKWSDSVFQRTPESAPSGPPENFEVKP LRGKGTAVVATWDPPEEPNGRIKEFILTYVPAMKPFETKSVKYHGSTTTATIDNLTPGDR YIFTIKATNRKGQGPQSKTFSVAMPG-----------TGSSAASAFS---------KSK- ------------DSRRT------------------------------------------- --------------GHT---PSKQDTDHD------------------------------- ---------------------------------------------------DIQS----T EVPEIP----------------TIQKQ------------------------------PLP --------AAPVNRRFRPLSQTRSYHSIFSSVRGSIRRAGN-----------RGSNR--- ------------------------------RRAKNDEEQEEE------------------ ------------------------------------------------------------ --------EEKE----------------------------NKVPTTPP------PVEE-- --------------------------------------TTTMEFVPEPK----------- ------------------------------------DN---------------------- ----------------------DV------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------SP----- ------------------------------------------------------------ --------------ETEDEDEYDEEPLTTKTPSLKVLTP--------------------- ----------------------------------------SPTKPAFN------------ ------------------------------------------------------------ ---------------------------------RLNPPR--------------------- ------------------------------------------------------------ -------------------------------R---------------------------- ---------------------------------------------------RP------F KIRVH--------------------------------------------------QKAG- ------------------------SKDAS------------------------------- ----------------------------------------------------------TD S------------------SSSSSSASSSSSSA-SSSSSSSS--ASSSS----------- -----SSNSNSPTS-------------TSSSTSLDSSS----------SS--------SS S--------------------PST------------------------------------ -----------------------------TSLSS-------------------------- ------------------------------------------------------------ ----------PS--QESAASRKDYVALTYPE-----------------SKNTFEKSSITH AK---------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------------PSTSLAKV- N---------------------------------SSQQTHVTP----------------- ---------------------------------VGRGSTSAG------------------ ---------------------------------------RAS------------------ ------------------------------------------------------------ -----------------------------------------------------G------ ------------------------------------------------------------ --------------------------------------------------------TGFG --------------------------------------SR-------------------- ------------YGLGR-----------------------------------RYPGSLLR GNSTRMLNGYKPAVISQSSS-------PRR------------------------------ -T------QSQVTSSIHSSATSQATLPENTQNH-------EKSSTLNPSTSKSKSGG--- -TSNGEDVLESHNS---------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -DKSRST----------------------------------------------------- ------------LESR-------------------------------------------- ---------------------------S-------------------------------- --------------------------HGS------------------------------- --------------------------------------------------------TSLQ VTNPSTSQRNANHPSTAN------------------------------------------ ------------------------TS---------------------------------- -----GLSQRTS-----------------QRESHSSARSHDTHNSQSSHTSSEGDTSNVE GNDDTNYKNTERELTKVEDSALTTRTQPTEKPMKKDKEKDEGT----------------- ------------------------------------------------------------ ----------------------------KEKP---------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------PVSAGTR VRPSFAERYPWLASRYPG---------KVIS----------------------SARI--- ---------------------------------------AS---PRQDSRVP-------- ------------------------------------------------------LTRMS- ------------------------------------------------------------ ------------------------------------------------------------ ----SSV----------------------------------------------------- -------------------GAG---------------------------RPVLRGTTTRV -------------------SGATGAAGVPSVQETSEDPSASSTRDSLKNGFGASSVKPSL INQNVGSGGTRNP------------------------ATSSSSSSSSP---------SIS ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------------S S----------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------PDHHHHSLSGHRDSGEP SHRELTNDKHSNEDYLSEKNGEND------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------------KV ADPIEA------------------------------------------------------ -----------------QEKP----AESDKNAEDNASVDTGESSSRTRPGTSSGVPL--- -----------------TNRR------P-------------------------------- ------------------------------------------------------------ -------------------------GVGVNGRV--------------------------- ----------------RSPLLPNRQFGGSRLPLRVQPAQN----------S--------- -RLGS-STSDSTSSSSDSAS-----------------SSNLPQPV--------------- ------------------------------------------------------------ -------------------------------------------------LTSESDISSDT TVTRTGGLIGGNSHST---LTSSSSS-------------SSRDSFR------NNGS---- ---------------RPRYSI------RG------------KQ----------------- --------NN-------------------------------------------------- -----------------------GRGIKPSN------G------N--------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------GKNGRPNLTAT-------- --DDK-ESSSSHGASKATGQRFITGPDGTKWVVDLEQGILMNGDGRVLQDSQGKPKRVVL GEDGRTIFDHMGSPLVSQDGIALFGHGRDSQPVINPKDK-VLMVGGKRVLGLD--RPRPR T--S-------------------------------------------------------- --------TT-----------TTT------------------------------------ --------------------------------TTT------------------TMAP--T ----------TTPEP-------------TTTDWT--------TEE-----------FTTG FPYPTCPPGTFSKTDEYGYPIL-DSDGILDCY--------------------------P- ------------------------EEDS-SGMEMDFMLTM---TRVP--DALVLKKD--- ---------------------E--------FV-VQ-TTP-------P-----P------- -------TT----------------------------------------------TTT-- TTTT---TTTTEITMPKVHIRP----------------------V--------------- -----NKGPSNEFDLSGKKRFT--------------------------APYVNYIQKDPG APCSLTEALEYLQVDILENLMKNDSLATNHNQPPKNKPHNFTVVAMEGCHSFIILDWARP LKDDMVSGYMVQSASYDDILNNRWSSKAATGTHLAVENLKPNS----------------- -------------RYYFRVQAKNVFGVGPFSETLSYVTESDDPLLIERPPG--------- ------GEPIWIPFSFKFNPVHSSCKGSQYVKRTWYRKFVGVVLCNSLRYKIFMGDSL-R -DPFYSIGDTFGQGEDHCQFVDSYRDGRTGPAYLSNNLPTAQGYYRSYRQEPVTFGVIGR RTPHPFVGWYECGVPIPGKW---------------------------------------- ------------------------------------------------------ >ENSACLP00000030654 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------------MA-------- ---LATGRT---------------LVALFLTLCGPGC----------------------- ------------------------S---------------------WAAEKLP------- -----------------------RPQNVKPTSVEKGLRESWEPSIHLDGRPV----DRFM ------------------------------------------------------I-SSSK P-----------------------------------------------TR---------- -----------SHRFTKASKDSRAPMLEDV--------------------------DP-- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------EWVNLDGFAVLGGAP------------ ------------------VSNLSAA----------------------------------- ------------------------------------------------------------ --------------------GP-------------------------------------- ------------------VRSSQTVVPRNHS-SVKRATRMDRKAQLS--PN--------- -----------VRTHR---------RAPQSSSGPRQ-------PE-RVLA-----GVPL- -LERRRQHY------------AKPQSDQRNRLARKL---TSESV---------------- ---------HVVSLQAQK-----------------AQGQSKPANRPVTTKTTTPAP---- ---PEH-EAQDISVRVMSPKSVLISWVDPAVE-MEK-VAPGAS-RSYTVRYREKGESARW EYKESTQRRILIDTLSADSMYEFSVRISQEENHSKWSDSVFQRTPESAPSGPPENFEVKP LRGKGTAVVATWDPPEEPNGRIKEFILTYVPAMKPFETKSVKYHGSTTTATIDNLTPGDR YIFTIKATNRKGQGPQSKTFSVAMPG-----------TGSSAASAFS---------KSK- ------------DSRRT------------------------------------------- --------------GHT---PSKQDTDHD------------------------------- ---------------------------------------------------DIQS----T EVPEIP----------------TIQKQ------------------------------PLP --------AAPVNRRFRPLSQTRSYHSIFSSVRGSIRRAGN-----------RGSNR--- ------------------------------RRAKNDEEQEEE------------------ ------------------------------------------------------------ --------EEKE----------------------------NKVPTTPP------PVEE-- --------------------------------------TTTMEFVPEPK----------- ------------------------------------DN---------------------- ----------------------DV------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------SP----- ------------------------------------------------------------ --------------ETEDEDEYDEEPLTTKTPSLKVLTP--------------------- ----------------------------------------SPTKPAFN------------ ------------------------------------------------------------ ---------------------------------RLNPPR--------------------- ------------------------------------------------------------ -------------------------------R---------------------------- ---------------------------------------------------RP------F KIRVH--------------------------------------------------QKAG- ------------------------SKDAS------------------------------- ----------------------------------------------------------TD S------------------SSSSSSASSSSSSA-SSSSSSSS--ASSSS----------- -----SSNSNSPTS-------------TSSSTSLDSSS----------SS--------SS S--------------------PST------------------------------------ -----------------------------TSLSS-------------------------- ------------------------------------------------------------ ----------PS--QESAASRKDYVALTYPE-----------------SKNTFEKSSITH AK---------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------------PSTSLAKV- N---------------------------------SSQQTHVTP----------------- ---------------------------------VGRGSTSAG------------------ ---------------------------------------RAS------------------ ------------------------------------------------------------ -----------------------------------------------------G------ ------------------------------------------------------------ --------------------------------------------------------TGFG --------------------------------------SR-------------------- ------------YGLGR-----------------------------------RYPGSLLR GNSTRMLNGYKPAVISQSSS-------PRR------------------------------ -T------QSQVTSSIHSSATSQATLPENTQNH-------EKSSTLNPSTSKSKSGG--- -TSNGEDVLESHNS---------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -DKSRST----------------------------------------------------- ------------LESR-------------------------------------------- ---------------------------S-------------------------------- --------------------------HGS------------------------------- --------------------------------------------------------TSLQ VTNPSTSQRNANHPSTAN------------------------------------------ ------------------------TS---------------------------------- -----GLSQRTS-----------------QRESHSSARSHDTHNSQSSHTSSEGDTSNVE GNDDTNYKNTERELTKVEDSALTTRTQPTEKPMKKDKEKDEGT----------------- ------------------------------------------------------------ ----------------------------KEKP---------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------PVSAGTR VRPSFAERYPWLASRYPG---------KVIS----------------------SARI--- ---------------------------------------AS---PRQDSRVP-------- ------------------------------------------------------LTRMS- ------------------------------------------------------------ ------------------------------------------------------------ ----SSV----------------------------------------------------- -------------------GAG---------------------------RPVLRGTTTRV -------------------SGATGAAGVPSVQETSEDPSASSTRDSLKNGFGASSVKPSL INQNVGSGGTRNP------------------------ATSSSSSSSSP---------SIS ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------------S S----------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------PDHHHHSLSGHRDSGEP SHRELTNDKHSNEDYLSEKNGEND------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------------KV ADPIEA------------------------------------------------------ -----------------QEKP----AESDKNAEDNASVDTGESSSRTRPGTSSGVPL--- -----------------TNRR------P-------------------------------- ------------------------------------------------------------ -------------------------GVGVNGRV--------------------------- ----------------RSPLLPNRQFGGSRLPLRVQPAQN----------S--------- -RLGS-STSDSTSSSSDSAS-----------------SSNLPQPV--------------- ------------------------------------------------------------ -------------------------------------------------LTSESDISSDT TVTRTGGLIGGNSHST---LTSSSSS-------------SSRDSFR------NNGS---- ---------------RPRYSI------RG------------KQ----------------- --------NN-------------------------------------------------- -----------------------GRGIKPSN------G------N--------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------GKNGRPNLTAT-------- --DDK-ESSSSHGASKATGQRFITGPDGTKWVVDLEQGILMNGDGRVLQDSQGKPKRVVL GEDGRTIFDHMGSPLVSQDGIALFGHGRDSQPVINPKDK-VLMVGGKRVLGLD--RPRPR T--S-------------------------------------------------------- --------TT-----------TTT------------------------------------ --------------------------------TTT------------------TMAP--T ----------TTPEP-------------TTTDWT--------TEE-----------FTTG FPYPTCPPGTFSKTDEYGYPIL-DSDGILDCY--------------------------P- ------------------------EEDS-SGMEMDFMLTM---TRVP--DALVLKKD--- ---------------------E--------FV-VQ-TTP-------P-----P---T--- -------TT----------------------------------------------TTT-- TTTT---TTTTEITMPKVHIRP----------------------V--------------- -----NKGPSNEFDLSGKKRFT--------------------------APYVNYIQKDPG APCSLTEALEYLQVDILENLMKNDSLATNHNQPPKNKPHNFTVVAMEGCHSFIILDWARP LKDDMVSGYMVQSASYDDILNNRWSSKAATGTHLAVENLKPNS----------------- -------------RYYFRVQAKNVFGVGPFSETLSYVTESDDPLLIERPPG--------- ------GEPIWIPFSFKFNPVHSSCKGSQYVKRTWYRKFVGVVLCNSLRYKIFMGDSL-R -DPFYSIGDTFGQGEDHCQFVDSYRDGRTGPAYLSNNLPTAQGYYRSYRQEPVTFGVIGR RTPHPFVGWYECGVPIPGKW---------------------------------------- ------------------------------------------------------ >ENSHBUP00000012034 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------------MA-------- ---LATGRT---------------LVALFLTLCGPGC----------------------- ------------------------S---------------------WAAEKLP------- -----------------------RPQNVKPTSVERGLRESWEPSIHLDGRPV----DRFM ------------------------------------------------------I-SSSK P-----------------------------------------------TR---------- -----------SHRFTKASKDSRAPMLEDV------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------A----------------------------------- ------------------------------------------------------------ --------------------GP-------------------------------------- ------------------VRSSQTVVPRNHS-SVKRATRMDRKAQLS--PN--------- -----------VRTHR---------RAPQSSSGPRQ-------PE-RVLA-----GVPL- -LERRRQHY------------AKPQSDQRNRLARKL---TSESV---------------- ---------HVVSLQAQK-----------------AQGQSKPANRPVTTKTTTPAP---- ---PEH-EAQDISVRVMSPKSVLISWVDPAVE-MEK-VAPGAS-RSYTVRYREKGESARW EYKESTQRRILIDTLSADSMYEFSVRISQEENHSKWSDSVFQRTPESAPSGPPENFEVKP LRGKGTAVVATWDPPEEPNGRIKEYILTYVPAMKPFETKSVKYHGSTTTATIDNLTPGDR YIFTIKATNRKGQGPQSKTFSVAMPG-----------TGSSAASAFS---------KSK- ------------DSRRT------------------------------------------- --------------GHT---PSKQDTDHD------------------------------- ---------------------------------------------------DIQS----T EVPEIP----------------TIQKQ------------------------------PLP --------AAPVNRRFRPLSQTRSYHSIFSSVRGSIRRAGN-----------RGSNR--- ------------------------------RRAKNDEEEEE------------------- ------------------------------------------------------------ -----------E----------------------------NKVPTTPP------PVEE-- --------------------------------------TTTMEFVPEPK----------- ------------------------------------DN---------------------- ----------------------DV------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------SS----- ------------------------------------------------------------ --------------ETEDEDEYEEEPLTTKTPSLKVLTP--------------------- ----------------------------------------SPTKPAFN------------ ------------------------------------------------------------ ---------------------------------RLNPPR--------------------- ------------------------------------------------------------ -------------------------------R---------------------------- ---------------------------------------------------RP------F KIRVH--------------------------------------------------QKAG- ------------------------SKDAS------------------------------- ----------------------------------------------------------TD S------------------SSSSSSASSSSSSASSSSSSSSS--ASSSS----------- -----SSNSNSPTS-------------TSSSTSLDSSS----------SS--------SS S--------------------PST------------------------------------ -----------------------------TSLSS-------------------------- ------------------------------------------------------------ ----------PSLTQESAASRKDYVALTYPE-----------------SKNTFEKSSITH AK---------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------------PSTSLAKV- N---------------------------------SSQQTHVTP----------------- ---------------------------------VGRGSASAG------------------ ---------------------------------------RAS------------------ ------------------------------------------------------------ -----------------------------------------------------G------ ------------------------------------------------------------ --------------------------------------------------------TGFG --------------------------------------SR-------------------- ------------YGLGR-----------------------------------RYPGSLLR GNSTRILNGYKPAVISQSSS-------LRR------------------------------ -T------QSQVTSSIHSSATSQATLPENTQNH-------EKSSTLNPSTSKSKSGG--- -TSNGEDVLESHNS---------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -DKSRST----------------------------------------------------- ------------LESR-------------------------------------------- ---------------------------S-------------------------------- --------------------------HGS------------------------------- --------------------------------------------------------TSLQ VTNPSTSQRNANHPSTAN------------------------------------------ ------------------------TS---------------------------------- -----GLSQRTS-----------------QRESHSSARSHDTHNSQSSHTSSEGDTSNVE GNDDTNYKNTKRELTKVEDSALTTRTQPTEKPMKKDKEKDEGT----------------- ------------------------------------------------------------ ----------------------------KEKP---------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------PVSAGTR VRPSFAERYPWLASRYPG---------KVIS----------------------SARI--- ---------------------------------------TS---PRQDSRVP-------- ------------------------------------------------------LTRMS- ------------------------------------------------------------ ------------------------------------------------------------ ----SSV----------------------------------------------------- -------------------GAG---------------------------RPVLRGTTTRV -------------------SGATGAAGVPSVQETREDPSASSTRDSLKNGFGASSVKPSL INQNVGSGGTRNP------------------------ATSSSSSFSSP---------SIS ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------------S S----------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------PD-HHHSLGGHRNSSEP SHRELTNDKHTNEDYLSEKNGEND------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------------KV ADPIEA------------------------------------------------------ -----------------QEKP----AESDKNVEDNASVDTGESSSRTRPGTSSGVPL--- -----------------TNRR------P-------------------------------- ------------------------------------------------------------ -------------------------GVGVNGRV--------------------------- ----------------RSPLLPNRQFGGSRLPLRVQPAQN----------S--------- -RLGS-STSDSTSSSSDSAS-----------------SSNLPQPV--------------- ------------------------------------------------------------ -------------------------------------------------LTSESDISSGT TVTRTGGLIGGNSHST---LTSSSSS-------------SSRDSFR------NNGS---- ---------------RPRYSI------RG------------KQ----------------- --------NN-------------------------------------------------- -----------------------GRGIKPSN------G------N--------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------GKNGRPNLTAT-------- --DDK-ESSSSHGASKATGQRFITGPDGTKWVVDLEQGILMNGDGRVLQDSQGKPKRVVL GEDGRTIFDHMGSPLVSQDGIALFGHGRDSQPVINPKDK-VLMVGGKRVLGLD--RPRPR T--S-------------------------------------------------------- --------TT-----------TTT------------------------------------ --------------------------------TTT------------------TMAP--T ----------TTPEP-------------TTTDWT--------TEE-----------FTIG FPYPTCPPGTFSKTDEYGYPIL-DSDGILDCY--------------------------P- ------------------------EEDS-SGMEMDFMLTM---TRVP--DALVLKKD--- ---------------------E--------FV-VQ-TTP-------P-----P------- -------TT----------------------------------------------TTT-- TTTT---TTTTEITMPKVHIRP----------------------I--------------- -----NKGPSNEFDLSGKKRFT--------------------------APYVNYIQKDPG APCSLTEALEYLQVDILENLMKNDSLATNHNQPPKNKPHNFTVVAMEGCHSFIILDWARP LKDDMVSGYMVQSASYDDILNNRWSSKAATGTHLAVENLKPNS----------------- -------------RYYFRVQAKNVFGVGPFSETLSYVTESDDPLLIERPPG--------- ------GEPIWIPFSFKFNPVHSSCKGSQYVKRTWYRKFVGVVLCNSLRYKIFMGDSL-R -DPFYSIGDTFGQGEDHCQFVDSYRDGRTGPAYLSNNLPTAQGYYRSYRQEPVTFGVIGR RTPHPFVGWYECGVPIPGKW---------------------------------------- ------------------------------------------------------ >ENSONIP00000016683 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------AAEKPP------- -----------------------RPQNVKPTSVEKGLRESWEPSIHLDGRPV----DRFM ------------------------------------------------------I-SSSK P-----------------------------------------------TR---------- -----------SHRFTKASKDSRAPMLEDVACFCHYFIFLHPWHHTSSKYPVFLFLDP-- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------EWVNLDGFAVLGGAPFDEIGTSKDITE TFLGTSVCTLSKRMCLEWK----------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------RTHR---------RAPQSSSGPRQ-------PE-RVLA-----GVPL- -LERRRQHY------------AKPQSDQRNRLARKL---TSESV---------------- ---------HVVSLQAQK-----------------AQGQSEPANRAVTTKTTTPAP---- ---PEH-EAQDISVRVMSPKSVLISWVDPAVE-MEK-VAPGAS-RSYTVRYREKGESARW EYKESTQRRILIDTLSADSMYEFSVRISQEENHSKWSVSVFQRTPESAPSGPPENFEVKP LRGKGTAVVATWDPPEEPNGRIREYILTYVPAMKPFETKSVKYYGSTTTATIDGLTPGDR YIFTIKATNRKGQGPQSKTFSVAMPG-----------S-SSATSAFS---------KSK- ------------DSRRT------------------------------------------- --------------GHT---PSKQDTDHD------------------------------- ---------------------------------------------------DIQS----T EAPEIP----------------TIQKQ------------------------------PLP --------AAPVSRRFRPLSQTRSYHSIFSSVRGSIRKAGN-----------RGSNR--- ------------------------------RRAKNDEEEEEE------------------ ------------------------------------------------------------ --------EEEE----------------------------NKVPTTPP------PVEE-- --------------------------------------TTTMEFVPEPKE---------- -----------------------------------TDN---------------------- ----------------------DV------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------SP----- ------------------------------------------------------------ --------------E--------------------ILTP--------------------- ----------------------------------------SPTKPAFN------------ ------------------------------------------------------------ ---------------------------------RLNPPR--------------------- ------------------------------------------------------------ -------------------------------R---------------------------- ---------------------------------------------------RP------F KIRVH--------------------------------------------------QKAG- ------------------------SKDA-------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------SA------------------------------------ -----------------------------TSLSS-------------------------- ------------------------------------------------------------ ----------PSLTQESAASRKDYIALTYPE-----------------SKNIFEKSSITH AK---------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------------PSTSLAKR- N---------------------------------SSQQTHVTP----------------- ---------------------------------VGRGSTSAG------------------ ---------------------------------------RAS------------------ ------------------------------------------------------------ -----------------------------------------------------G------ ------------------------------------------------------------ --------------------------------------------------------TGFG --------------------------------------SR-------------------- ------------YGLGR-----------------------------------RYPGSLLR GNSTRMLNGYKPAVISQSSS-------PRR------------------------------ -T------QSQVTSNIHSSATSQATLPENTQNH-------EKSSTLNPSISKSKSGR--- -TSNGEDVLDSYNS---------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -DKSRST----------------------------------------------------- ------------LESR-------------------------------------------- ---------------------------S-------------------------------- --------------------------HGS------------------------------- --------------------------------------------------------TSLQ VTNPSTSQRNAN-TSTAN------------------------------------------ ------------------------TS---------------------------------- -----GLSQRTS-----------------QRGSHSSARSRDTHNSQSSHTSSERDTSNVE GNDDTNYKNTERELTKVEDSALTTITQPTEKPMKKDKEKDEGA----------------- ------------------------------------------------------------ ----------------------------KEKP---------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------PVSAGTR VRPSFAERYPWLASRYPG---------KVIS----------------------TTRI--- ---------------------------------------TS---PRQDSRVP-------- ------------------------------------------------------LTRMS- ------------------------------------------------------------ ------------------------------------------------------------ ----SSV----------------------------------------------------- -------------------GAG---------------------------RPVLRGTTTRV -------------------SGATGAAGVPSLQETSEDPSTSSTRDSLKNGFGASSVKPSL INQNVGSGGARNP------------------------TTSSSSSSSSP---------SIS ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------------S S----------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------PD-HHHSLSGHRDSSEP SHRELTNAKSSNEDYLSEKSGEND------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------------KV ADPIEA------------------------------------------------------ -----------------QEKP----AESDKNAEDNASVDTGESSPRTRPGTSSGVPL--- -----------------ANRR------P-------------------------------- ------------------------------------------------------------ -------------------------GVGVNGRV--------------------------- ----------------RSPLLPNRQFGGSRLPLRVQPAQN----------S--------- -RLGS-STSDSISSSSDSAS-----------------SSNLPQPV--------------- ------------------------------------------------------------ -------------------------------------------------RTSDSDISSGT TVTRTGELIGGNSHST---LASSSSS-------------SSRDSFR------NNGS---- ---------------RPRYSI------RG------------KQ----------------- --------NN-------------------------------------------------- -----------------------GRGIKPGN------G------N--------------- ------------------------------------------------------------ -----------------GNVNSYMQ----------------------------------- -LC--------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------EVSDVSFTQFFK DASAYVLY---------------------------------------------------- ---------------------------------------LPGKNGRPNLTAT-------- --DDK-ESSSSHGTSKATGQRFITGPDGTKWVVDLEQGILMNGDGRVLQDSQGKPKRVVL GEDGRTIFDHMGSPLVSQDGIALFGHGRDSQPVINPKDK-VLMVGGKRVLGLD--RPRPR T--S-TT----------------------------------T--TTA------------- --------TT-----------TTT------------------------------------ --------------------------------TTT------------------TMAP--T ----------TTPEP-------------TTIDWT--------TEE-----------FTTG FPYPTCPPGTFSKTDEYGYPVL-DSDGILDCY--------------------------P- ------------------------E-----GMEMDFMLTM---TRVP--DALVLKKD--- ---------------------E--------FV-VQ-TTP-------P-----P------- -------TTTTA-------------------------------------------TTT-- TTTT---TTTTKITTPEVHIRP----------------------M--------------- -----NKGPSNEFDLSGKKRFT--------------------------APYVNYIQKDPG APCSLTEALEYLQVDILENLMKNDSLAANHNQPPKNKPHNFTVVAMEGCHSFIILDWARP LKDDMVSGYMVQSASYDDILNNRWSSKAATGTHLAVENLKPNS----------------- -------------RYYFRVQAKNVFGVGPFSETLSYVTESDDPLLIERPPG--------- ------GEPIWIPYSFKFNPVHSSCKGSQYVKRTWYRKFVGVVLCNSLRYKIFMGDSL-R -DPFYSIGDTFGQGEDHCQFVDSYRDGRTGPAYLSNNLPTVQGYYRSYRQEPVTFGVIGR RTAHPFVGWYECGVPIPGKW---------------------------------------- ------------------------------------------------------ >ENSKMAP00000020789 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------------MA-------- ---RAASRT---------------LLALFVTFCASRC----------------------- ------------------------G---------------------WTAEKPL------- -----------------------RSQNGKQTAVDKVLRESWQPSIHLDGRPV----DRFV ------------------------------------------------------M-SSSK P-----------------------------------------------SR---------- -----------SHRFTKLSKDTRSHPPEDV--------------------------DP-- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------EIINLDGFAVLVNPP------------ ------------------VNTSA------------------------------------- ------------------------------------------------------------ --------------------GL-------------------------------------- ------------------VKSSQTAA-RNHS-AAGRTTRVNRTARPAGLTF--------- -----------NRMLR---------RAPQSSSGPRQ-------PE-SAVA-----GTPL- -LERRRQRQ------------TKPQADQRNRPTPKL---ASESV---------------- ---------HVVSLQAQK-----------------AQGRSAPANRDITAKTTPPEP---- ---PEY-EARDISVRVISPKSVLISWVDPAVE-MGK-VAPGAS-RSYTVRFREKGESARW EYKESTQRRMMIDTLSADGMYEFSVRISQGEKHSKWSVSVFQRTPESAPSGPPEDFEVKP LRGKGTAVIATWDPPEEPNGRITEYILSYAPAMKPFGMKSVTYRGGTTTATIDGLTPGER YIFKIRAANRRGMGPQSKVFSVVMPQ-----------S-RSAVSSFS---------ETK- ------------DSHM-------------------------------------------- ---------------------SKQDEDKE------------------------------- -------------------------------------------------KPNPPS----K EVPEEP----------------TATPK------------------------------PKP --------VSHNNRRVRPLSQTRSYHSIFSSVRGSVRNGLN-----------RGSSK--- ------------------------------GKA--KEDEEQE------------------ ------------------------------------------------------------ --------EE-------------------------------KVPTTPP------PVEE-- ---------------------------------------TTIKVMQETEE---------- -----------------------------------LDN---------------------- ----------------------DV------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------SL----- ------------------------------------------------------------ --------------LSEDEVGYIKEPVTTETPSLKVFTP--------------------- ----------------------------------------SPTKPVLK------------ ------------------------------------------------------------ ---------------------------------KPYQPN--------------------- ------------------------------------------------------------ -------------------------------R---------------------------- ---------------------------------------------------RP------V KIRVH--------------------------------------------------QKAG- ------------------------SKATS------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -----SSSSNNPS----------------------SSS----------SA--------SS S--------------------PSS------------------------------------ -----------------------------SATSSF------------------------- ------------------------------------------------------------ ---------PSSRIQESAASRKDHVVSAYPN-----------------TQNIYNRPNVTQ AK---------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------------PSTTGQKE- S---------------------------------NSQQTDTTP----------------- ---------------------------------MGTGSSSAE------------------ ---------------------------------------RSS------------------ ------------------------------------------------------------ -----------------------------------------------------G------ ----------S------------------------------------------------- -------------------------------------------------------ASGFP --------------------------------------SR-------------------- ------------HGFSR-----------------------------------RHPGISFR GNTTRLLNGYKPAVTTQLKI-------PSR------------------------------ -T------QSQVSLNPRSSASSQSILPERTQSH-------ETSSTFIPKTSTPNSGS--- -TSNSHSTSDSNNS---------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -NKSQFT----------------------------------------------------- ------------SNSR-------------------------------------------- ---------------------------SQD----------------------AKILK--- ------------------------DTHSS------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------TSQ------------------RRTIHHSTGDK---- ----PGSSQSTS-----------------QRAPHSSVTSRDTHNSLGSHTSPDLNTSFRE GNDDSSYKHEEDKKNKVE------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------EPTSS--------------------------------- ------------------------------SRAQPTVQNKKEER-KDESVNKKPTLSRTR ISSSFAEKIPWLASRYPG---------KFVL----------------------GTRA--- ---------------------------------------SS---PRQDGGTS-------- ------------------------------------------------------LTRVS- ------------------------------------------------------------ ------------------------------------------------------------ ----SSV----------------------------------------------------- -------------------GAG---------------------------RPLVVGTPTRV -------------------SGAAGVTGESLKQETTEDLRTLSKHDSLKNSVGVSSVKPSL NNQNTRSSDSNSP------------------------TTSFSSSAS-------------- -----------------TFSNSGS------------------------------------ --------------NPLEKTT--------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------GHKDSS-- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------------DSNHKEISN SDTHKDNIDARSRENKEKAADHKAVQRTPTSSSAV------------------------- ------------------------------------------------------------ ----------------------------HRNGENEESMSTRETSSRTRTGISTGASP--- -----------------S-RR------L-------------------------------- ------------------------------------------------------------ -------------------------GVGMNGRV--------------------------- ----------------RSSLLANTQFGGSRLPIRPQQVQN----------S--------- -RLGG-STSDSSSS-LDSSA-----------------SLNFPKPVLNSAHNAGSDTTVKK PW---------------------------------------------------------- ------------------------------------------------------------ ---------GGNSPST-----------------------SSSSSIR------NPGG---- ---------------RARYPI-----IRG------------KP----------------- --------NN-------------------------------------------------- -----------------------GGGFRPGN------G------N--------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------VGKDEQPNLTAT-------- --NAK-ETSSSLGTSKATGQKFITGPDGTKWVVDLERGVLMNQDGKILQDSQGKPKRVVL GEDGRTIFDHMGSPLVSQEGIALFGHGRDSQPVVNPKEK-VLTVGGKPVLGLN--VLRPR T--S-IT----------------------------------T--TT-------------- --------T--------------------------------------------------- -------------------------------------------------------AP--P ----------TTSEP-------------TTTEWT--------TEE-----------FSTA LPYPTCPPGTFSKTDEYGYPLL-DPEGILDCY--------------------------P- ------------------------EEDS-SGMEMDHMLTV---SMVP--DALALEK---- -------------------------------V-IK-NTL-------P-----P---S--- -------TTTTA-------------------------------------------TTS-- TTTTTTVTT--------PDSRL----------------------V--------------- -----NKRPLSEFDLSGKKRFT--------------------------APYVNYIQKDPG APCSLTEALEYLQVDILEDVIKKD-MAANQNQPPKHKPHNLTVVAMEGCHSFIILDWARP LKDDMVSGYMVYSASYDDVLNNRWSPKASDGTHLAVENLKPNS----------------- -------------RYYFKVRAKNVFGLGPFSETLTYETESDDPFLIERPPG--------- ------GEPIWVPFTFKYNPVHSSCKGSQFVKRTWYRKFVGVVLCNSLRYKIFMGDGL-R -EPFYSIGDTLGQGEDHCQFVDSYRDGRTGPSDFSYNLPSAQGYYRAYRQEPVTFGVIGR RTAHHFVGWYECGVPIPGKW---------------------------------------- ------------------------------------------------------ >ENSFHEP00000000117 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------------MA-------- ---PAASRT---------------LLALFVAFCAPQC----------------------- ------------------------G---------------------WTEEKPL------- -----------------------RPQSGRQTAVDKVFRESWEPSIHLDGRPV----DRFV ------------------------------------------------------L-NSNK P-----------------------------------------------PR---------- -----------SHRLTKASKDSRPHPMEDV--------------------------DP-- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------EWINLDGFAVLGHAP------------ ------------------VNNST------------------------------------- ------------------------------------------------------------ --------------------GF-------------------------------------- ------------------VRSSQTAV-RNNS-ATGRKRRVDRMTQPMDLAN--------- -----------TRTHR---------RAPQSSSGPRQ-------PE-RALA-----GTPL- -LERRRQHR------------IQPQADQRNRQTLKL---TSESV---------------- ---------HVVSLQAQK-----------------AHGQSLPNNRAATAKTSPPEP---- ---PEY-EARDISVRVMSPKSVLISWVDPAVE-MGK-VDPEAS-RSYTVRFREKGESARW EYKESTQRRMMIDTLSADGMYEFSVRISQGEKQGKWSVSVFQRTPESAPSGPPESFEVKP LRGKGTAVIATWEPPEETNGRIREYILSYVPAMNPFRTKSVTYSGGTTTATIDGLTPGER YIFRIRATNRRGAGPQSKALNVAMPR-----------S-SSTLSSHS---------KPK- ------------DSKDT------------------------------------------- --------------GHT---TVKQDIDP-------------------------------- -----------------------------------------------------QP----T KVPEDP----------------VTTPK------------------------------PH- ----------NTNRRHRPLSQTRSFHSVFSTIRGSVRNPVN-----------RGSTR--- ------------------------------VAE--REQEEQK------------------ ------------------------------------------------------------ --------ND-------------------------------KIPTTSS------PVIE-- --------------------------------------TTT--VVPETKE---------- -----------------------------------LDN---------------------- ----------------------NV------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------SP----- ------------------------------------------------------------ --------------LSEEEVDYNEELLSTETPSLKVLTP--------------------- ----------------------------------------SPTKPVYK------------ ------------------------------------------------------------ ---------------------------------YPYRPN--------------------- ------------------------------------------------------------ -------------------------------R---------------------------- ---------------------------------------------------RP------I KIRVH--------------------------------------------------KKTG- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------SNNSSSLSSTGLTSSSSTS SSSSFAASSASSSSKNTFISSSRLPSSSHAESSIMASSDIQESAQSRMDNIGST------ -------NHETKNIDKIPEPTSSRDSLKPSITVSSQETESTSPGTTAERRGNAG------ ------------------------------------------------------------ --------------------------------------------------------FRLG --------------------------------------SR-------------------- ------------YNFGR-----------------------------------RQPGSVLR GNLTRLPNGYKPAVTTHLNI-------PGQ------------------------------ -S------QRQVASNTHSSEKELSPLKERSQNH-------ETSSASSPKFPKSTLGS--- -----------------------------------------------------SLD---- -------------------------------------------------------HQTA- -------------------------------------------------------SDIPV FDKSKVS----------------------------------------------------- ------------SESR-------------------------------------------- ---------------------------S-------------------------------- --------------------------HDSKVLQGSHASTSQSSP-SHNLN---------- -------------------------------------------------VGSSQSTSQ-- -TQPSTSQGN----------------R--------------------------------- ------------------------------------------------------------ -------------------------------------------NSQGSNTS--------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --FT--------------------------QDTSS------------------------- --SKKTDDINYNN----------------------------------RKDIEDTAKESTL NSRAHTTKEIRK------------------------------------------------ -----------------------------------------EEI-QIESTNKKPVVSRTR ISSSFAERFPWLADRYPG---------KFTSG-----------LG------TPSS----- ---------------------------------------------RKDARTP-------- -------------------------------------------------------TRVS- ------------------------------------------------------------ ------------------------------------------------------------ ----SSV----------------------------------------------------- -------------------GAG---------------------------RPLLKETQTRV -------------------SGAAGASGVSLKQEPIEDLKTTSRPDSIKNGVVMSAVKPHL PNQHAATSDTRNP------------------------TRMPSS----------------- -----------ETL---TSSNSGSSSLKKSSGLRDSSEAIHKEISKTEDK-RDNVDTIST ERNRKLSDPTAAQTNP-------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------ASPSV------------------------- ------------------------------------------------------------ ----------------------------HKNAENNESVATRESLSRTRPGTSSGISP--- -----------------SIRR------P-------------------------------- ------------------------------------------------------------ -------------------------GVAMNGRV--------------------------- ----------------RSPLLANRQLGGSRHTVTPQLVQN----------S--------- -RLGA-STLNSS-----PTS-----------------SLNMPKPV--------------- ------------------------------------------------------------ -------------------------------------------------LTSTSDADSGA PVKKT-ELIGGNTHST------SSLP-------------SSRDSFK------NHGV---- ---------------RTRYPI-----IGR------------KP----------------- --------NN-------------------------------------------------- -----------------------GGRIKPGN------G------N--------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------GKNGKPNLTAT-------- --NKK-DTAPSHGSSKAVGHKFITGPDGTRWVVDLEKGVLMNQDGQVLQDSQGKPKRVVL GEDGRTIFDHMGSPLVSQEGIALFGHGRESQPVVNPKEK-VVMVGGKPVLGLD--VPLPR T--S-TT----------------------------------T--TT-------------- ------------------------------------------------------------ ------------------------------------------------------SAP--T ----------TTLEP-------------TTTDWT--------TED-----------YSTA LPYPTCPPGTFAKTDEFGYPAL-DSDGILDCY--------------------------P- ------------------------EEES-SGMEMDPMLTV---AMVP--DALGLEKD--- ---------------------E--------LL-VQ-TTL-------P-----P---T--- -------TTTIP-------------------------------------------TTT-- TTTTA-------IPATQPQARL----------------------P--------------- -----NRGPLSEFDISGKKRFT--------------------------APHVNYIQKDPG APCSLTEALEYLQVDVLENLMEKESMAVNQNQPPKHKPQNLTVVAMEGCHSFIILDWARP LKDDMVSGYMVHSASYDDVLNNRWSARVSTGTHLPVENLKPNS----------------- -------------RYYFKVQAKNVFGLGPFSETLTYVTESDDPLLIARPPG--------- ------GEPIWIPFTFKYNPVHSSCKGSQYVKRTWYKKFVGVVLCNSLRYKIFMGDGL-R -EPFYSIGDSMGQGEDHCQFVDSHRDGRTGPAYLSENLPSAQGYYRAYRQEPVTFGVIGR RTSHPFVGWYECGVPIPGKW---------------------------------------- ------------------------------------------------------ >ENSGAFP00000018673 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------------MA-------- ---AAASRT---------------LLALFFTLCAPQC----------------------- ------------------------G---------------------WAAEKTL------- -----------------------RPQSGKHTAADKLFRESWEPSIHLDGRPV----DRFD ------------------------------------------------------F-NSNK P-----------------------------------------------SR---------- -----------SHRFTKVNIESRPHSVEDV--------------------------DP-- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------EWINLDGFAVLSHAP------------ ------------------VNNSS-A----------------------------------- ------------------------------------------------------------ --------------------GF-------------------------------------- ------------------VR---TAV-RTNS-HAGRKTRVDRTTQPAGAAF--------- -----------TRTHM---------RAPQSSSGPRQ-------PE-KALP-----GTPL- -LERRRQQR------------TKPQADQRNRQAQKL---TSESV---------------- ---------HVVSLQAQK-----------------ALGQSLPNNGAATAKTSPPEP---- ---PEY-EAQDISVRVMSAKSVLISWVDPAVE-MRK-VDPRAS-RSYTVRFREKGESARW EYKESNQRRIMIDTLSADGMYEFSVRISQGEKQGKWSVSVFQRTPESAPSGPPENFEVKP LRGKGTAVIATWDPPEEPNGRIREYILSYAPAIKPFGMKTVTYREGTTKATIDGLTPGER YIFKIRATNRRGMGPQSKAFSVAMPR-----------S-SGTASSLS---------KPK- ------------DTQTN------------------------------------------- --------------SKT---IIEQVIDKK------------------------------- --------------------------------------------------SDLEP----T EVPEGP----------------ITTPK------------------------------PH- ----------NTNRRVRPLSQTRSYHSIFSSIRGSVRNTAN-----------RDSAR--- ------------------------------GAE--REYEEQV------------------ ------------------------------------------------------------ --------DD-------------------------------KKPTTPS------PVVE-- --------------------------------------TTT--LLPETKE---------- -----------------------------------LDN---------------------- ----------------------NV------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------SP----- ------------------------------------------------------------ --------------LSEEEVDYNVEPLTTETPSLKVLTP--------------------- ----------------------------------------SPTKSAFK------------ ------------------------------------------------------------ ---------------------------------RPYRPN--------------------- ------------------------------------------------------------ -------------------------------R---------------------------- ---------------------------------------------------RP------V KIRVH--------------------------------------------------QKTG- ------------------------SKSTS------------------------------- ----------------------------------------------------------SV S------------------SADSSSS---------------------------------- ------------------------------------------------SS--------SS S--------------------SSS------------------------------------ -----------------------------TSSSSSSVTSPVSSSSEKLLSSSSRSSL--- ------------------------------------------------------------ ---SHTSLLPSSHIPESKPSKKD------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ NIESTNHETAKIHQKPDLTSTRNSLTHGKPLIVAHSQETESTP--TDTS----------- -------------------------------------SSMTE------------------ ---------------------------------------HSS------------------ ------------------------------------------------------------ ---------------------------------------------------NAG------ ------------------------------------------------------------ --------------------------------------------------------SRFG --------------------------------------SR-------------------- ------------YGYGR-----------------------------------RQPGSFFR GNSTRLLNGYKPAVTTQFHL-------PSR------------------------------ -S------NNQVISNTSSSDKTQSTLTERSQNH-------DTSNPSDPKSSKTTSRS--- -----------------------------------------------------TLD---- -------------------------------------------------------SQ-T- -------------------------------------------------------SDSSA FDKSQ------------------------------------------------------- --------------SR-------------------------------------------- ---------------------------S-------------------------------- --------------------------HGSKLSQDSQPSTSHSSP-IHNLNTDISGSSQSV SQRHSSSTSQNNKNSRGSDTSSNQDLSLSKRTENIDYNNKDDIESKAEG----------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------------------SAS NSRAQTTQDIRE------------------------------------------------ -----------------------------------------ENR-QDESSNKKTVGPRTR ISSSFAERFPWLASHYPG---------RFTS----------------------SSRT--- ---------------------------------------SH---PRQDAKTP-------- ------------------------------------------------------LKRVS- ------------------------------------------------------------ ------------------------------------------------------------ ----SSV----------------------------------------------------- -------------------GAG---------------------------RPLLRETPTRV -------------------SGAAGASGVPLKQETTEDLKITSRPDSVKNS-VLNSGKSSL PNQHAATGDTRNP------------------------TTVSSS----------------- -----------ERL---MSSNSGSLLLEKSSVLRDFSEVNHKEIPKSEDNMRENVDTLST ERKGKLTDLTSVQTNP-------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------ASPSV------------------------- ------------------------------------------------------------ ----------------------------HSLEENNESVATKETLSRARAGTSTGISP--- -----------------SIRR------P-------------------------------- ------------------------------------------------------------ -------------------------GIGTTGRI--------------------------- ----------------RSSLLANRQLAGSRLSVRPQLVQN----------S--------- -RLGG-STPDSS-----STS-----------------SLNMPKPV--------------- ------------------------------------------------------------ -------------------------------------------------LTSASDADRDA TVKDT-ELTGGNTHSG------SSLP-------------SSRNTFR------NQGG---- ---------------RTRYPI-----VRG------------NP----------------- --------NN-------------------------------------------------- -----------------------GGRFKPGN------G------N--------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------GRNGKPNLTAM-------- --NGK-DTTSSDGNNKAVGHKFITGPDGTKWVVDLEKGVLMNQDGQVLQDSQGKAKRVVL GEDGRTIFDHMGSPLVSQEGIALFGHGRDSQPVVNPKDK-VLMVGGKPILGLD--VPPPK T--S-TT----------------------------------T--TT-------------- ------------------------------------------------------------ ------------------------------------------------------LAP--T ----------TTLEP--------------TTDWT--------TED-----------FSTA LPYPTCPPGTFSKTDEFGYPIL-DSEGILDCY--------------------------P- ------------------------EEES-SGMEMEPMLTV---AMMP--DALSLDKD--- ---------------------E--------LL-VQ-TTL-------P-----P---T--- -------TTTIA-------------------------------------------TTT-- TTTTV-------IPTTEPQVRV----------------------S--------------- -----NRGPVSEFDLSGKKRFT--------------------------APFVNYIQKDPG APCSLTEALEYLQVDVLENLMKNDHMAVNQNQPPKHKPQNFTVVAMEGCHSFIILDWAKP LKDDMVSGYMVHSASYDDVLNNRWSSKISNGTHLPVENLKPNS----------------- -------------RYYFKVQAKNVFGLGPFSETLTYVTESDDPLLIDRPPG--------- ------GEPIWIPFTFKYNPVHSSCKGSQYVKRTWYRKFVGVVLCNSLRYKIFMGDGL-R -EPFYSIGDTLGQGEDHCQFVDSHKDGRTGPAYLSETLPSAQGYYRAYRQEPVTFGVIGR RTSHPFVGWYECGVPIPGKW---------------------------------------- ------------------------------------------------------ >ENSXMAP00000003332 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------------MA-------- ---AAAGRT---------------LLALFFTFCAPQC----------------------- ------------------------G---------------------WAAEKTV------- -----------------------RPQSGKHTAAEKVFRESWEPSIHLDGRPV----DRFV ------------------------------------------------------F-NSNK P-----------------------------------------------SR---------- -----------SHRFTKVNKESRPHSVEDV--------------------------DP-- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------EWINLDGFAVLSHAP------------ ------------------VNNSS-A----------------------------------- ------------------------------------------------------------ --------------------GF-------------------------------------- ------------------VR---TAV-RSNS-AAGRKTRVDRTTQPAGAAF--------- -----------TRTHM---------RAPQSSSGPRQ-------PE-KALP-----GTPL- -LERRRQQR------------TKPQADQRNRQAQKL---TSESV---------------- ---------HVVSLQAQK-----------------ALGQSLPNNGAATAKTSPPEP---- ---PEY-EAQDISVRVMSAKSVLISWVDPAVE-MRK-VDPGAS-RSYTVRFREKGESARW EYKESNQRRIMIDTLSADGMYEFSVRISQGEKQGKWSVSVFQRTPESAPSGPPENFEVKP LRGKGTAVISTWDPPEEPNGRIREYILSYAPAIKPFGMKTITYREGTTKATIDGLTPGER YIFKIRATNRRGMGPQSKAFSVAMPR-----------S-SGTASLLS---------KPK- ------------DTQTT------------------------------------------- --------------SKT---IIEQDIDKK------------------------------- --------------------------------------------------SDLEP----T EVPEGP----------------ITTPK------------------------------PH- ----------NTNRRLRPLSQTRSYHSIFSSIRGSVRNTAN-----------RGSAR--- ------------------------------GAE--REHEEQV------------------ ------------------------------------------------------------ --------DD-------------------------------KKPTTPS------PVAE-- --------------------------------------TTT--VVPEIKE---------- -----------------------------------LDN---------------------- ----------------------NV------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------SP----- ------------------------------------------------------------ --------------LSEEEVDYNVEPLTTETPSLKVLTP--------------------- ----------------------------------------SPTKSAFK------------ ------------------------------------------------------------ ---------------------------------RPYRPN--------------------- ------------------------------------------------------------ -------------------------------R---------------------------- ---------------------------------------------------RP------I KIRVH--------------------------------------------------QKTG- ------------------------SKSTS------------------------------- ----------------------------------------------------------SV S------------------SAD---S---------------------------------- ------------------------------------------------SS--------SS S--------------------SSS------------------------------------ -----------------------------TSSSSSSATSPVSSTSENSFSSSSRSSL--- ------------------------------------------------------------ ---SHTSLLPSSHIPESEPSKKD------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ NIESTNHETAKIHQKPNLTSTRNSLRHGKPLIVVNSQETESTL--TDTS----------- -------------------------------------SSVAE------------------ ---------------------------------------RSS------------------ ------------------------------------------------------------ ---------------------------------------------------NAG------ ------------------------------------------------------------ --------------------------------------------------------SRFG --------------------------------------SR-------------------- ------------YGYGR-----------------------------------RQPGSFFR GNSTRLLNGNKPVVTTQFHL-------PSQ------------------------------ -S------NNQVISNTGSSDKTQSTLTERSQNH-------ETSNPSDPKSSKSTSRS--- -----------------------------------------------------TLE---- -------------------------------------------------------SQTT- -------------------------------------------------------SDSSV FDKSQPV----------------------------------------------------- ------------SESR-------------------------------------------- ---------------------------S-------------------------------- --------------------------HGSKLSQNSQASTSHSSP-IHNLNTDISGSSQSV SQRHSSSTSQ-NKNSRGSDTSSNRDISLSKRTGNTDYNNKDDIESKAEG----------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------------------STL NSRAQTTQDSRE------------------------------------------------ -----------------------------------------EDR-QDESSNKKTVGPRTR ISSSFAERFPWLASHYPG---------RFTS----------------------SSRT--- ---------------------------------------SY---PRQDARTP-------- ------------------------------------------------------LTRVS- ------------------------------------------------------------ ------------------------------------------------------------ ----SSV----------------------------------------------------- -------------------GAE---------------------------RPLLRKTPTRV -------------------SGEAGDSRVPLKQETTEDLKVTSRPDSMKNSVVLNSGKSSL PNQHAVTGDTRNP------------------------TTVSST----------------- -----------ETL---MSSNSGSLSLEKSSVLRDFSEVTHKEISKSGDNMRENVDTLST ERKGKLTDLTSVQTNP-------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------ASPSV------------------------- ------------------------------------------------------------ ----------------------------HRHEENNESVATKETLSRARAGTSTGISP--- -----------------SIRR------P-------------------------------- ------------------------------------------------------------ -------------------------GIGTNGRV--------------------------- ----------------RSSLLANRQLAGSRLSVRPQLVQN----------S--------- -RLGG-STPDSS-----STS-----------------SLNMPKPV--------------- ------------------------------------------------------------ -------------------------------------------------LTSASDADHDA TVKDT-ELTGGNTHSG------SSLP-------------SSRNTFR------NQGS---- ---------------RTRYPI-----VRG------------SP----------------- --------NN-------------------------------------------------- -----------------------GGRFKPGN------G------N--------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------GRNGKPNLTAM-------- --NGK-DTTSSHGSNKAVGQKFITGPDGTRWVVDLEKGVLMNQDGQVLQDSQGKAKRVVL GEDGRTIFDHMGSPLVSQEGIALFGHGRDSQPVVNPKDK-VLMIGGKPVLGLD--VPPPK T--S-TT----------------------------------T--TT-------------- ------------------------------------------------------------ ------------------------------------------------------LAP--T ----------TTLEP--------------TTDWT--------TED-----------FSTA LPYPTCPPGTFSKTDEFGYPIL-DPEGILDCY--------------------------P- ------------------------EEES-SGMEMDPMLTV---AMMP--DALNLDKD--- ---------------------E--------LL-VQ-TTL-------P-----P---T--- -------TTTIA-------------------------------------------TTT-- TTTTV-------IPTTEPQVRV----------------------S--------------- -----NRGPVSEFDLSGKKRFT--------------------------APFVNYIQKDPG APCSLTEALEYLQVDVLENLMEKDRMAVNQNQPPKHKPQNFTVVAMEGCHSFIILDWAKP LKDDMVSGYMVHSASYDDVLNNRWSSKISNGTHLPVENLKPNS----------------- -------------RYYFKVQAKNVFGLGPFSETLTYVTESDDPLLIDRPPG--------- ------GEPIWIPFTFKYNPVHSSCKGSQYVKRTWYRKFVGVVLCNSLRYKIFMGDGL-R -EPFYSIGDTLGQGEDHCQFVDSHKDGRTGPAYLSETLPTAQGYYRAYRQEPVTFGVIGR RTSHPFVGWYECGVPIPGKW---------------------------------------- ------------------------------------------------------ >ENSPMEP00000028412 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------------MA-------- ---AAARRT---------------LLALFFTFCAPQC----------------------- ------------------------G---------------------WAAEKTL------- -----------------------RPQSGKHTAADKVFRESWEPSIHLDGRPV----DRFV ------------------------------------------------------F-NSNK P-----------------------------------------------SR---------- -----------SHRFTKVNKESRPHSVEDV--------------------------DP-- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------EWINLDGFAVLSHVP------------ ------------------VNNSS-A----------------------------------- ------------------------------------------------------------ --------------------GF-------------------------------------- ------------------VR---TAT-RSNSAAAGRKTRVDRTTQPAGAAF--------- -----------TRTHR---------RAPQSSSGPRQ-------PE-KASP-----GTPL- -LERRRQQR------------TKPQADQRNRQAQKL---TSESV---------------- ---------HVVSLQAQK-----------------ALGQSLPNNGAATAKTSPPEP---- ---PEY-EAQDISVRVMSAKSVLISWVDPAVE-MRK-VDPGAT-RSYTVRFREKGESARW EYKESNQRRIMIDTLSADGMYEFSVRISQGEKQGKWSVSVFQRTPESAPSGPPENFEVKP LRGKGTAVIATWDPPEEPNGRIREYILSYAPAIKPFGMKTITYREGTTKATIDGLTPGER YIFKIRATNRRGMGPQSKAFSVAMPR-----------S-SGTASSLS---------KTK- ------------DTQTT------------------------------------------- --------------SKP---IIEQDTDKK------------------------------- --------------------------------------------------SDLEP----T EVPEGP----------------VTTPK------------------------------PH- ----------NTNRRVRPLSQTRSYHSIFSSIRGSVRNTAN-----------RGSTR--- ------------------------------GAE--REHEEQV------------------ ------------------------------------------------------------ --------DD-------------------------------KKPTTPP------PVVE-- --------------------------------------TTT--VVPETKE---------- -----------------------------------LDN---------------------- ----------------------DV------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------SP----- ------------------------------------------------------------ --------------LSEEEVDYDVEPLTTETPSLKVLTP--------------------- ----------------------------------------STTKSAFK------------ ------------------------------------------------------------ ---------------------------------RPYRPN--------------------- ------------------------------------------------------------ -------------------------------R---------------------------- ---------------------------------------------------RP------I KIRVH--------------------------------------------------QKSG- ------------------------SKSTS------------------------------- ----------------------------------------------------------SV S------------------SAD-------------------------------------- ----------------------------------------------------------SS S--------------------SSS------------------------------------ -----------------------------TSSSSSSATSPVSFSSENSFSSSSRSSL--- ------------------------------------------------------------ ---SHTSLLPSSHVPESEPSKKD------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ NIESTNHETAKIHQKPNLTSTRNSLTHGKPLVVVNSQETESAP--TDTS----------- -------------------------------------SSMAE------------------ ---------------------------------------RSS------------------ ------------------------------------------------------------ ---------------------------------------------------NAG------ ------------------------------------------------------------ --------------------------------------------------------SRFG --------------------------------------SR-------------------- ------------FGHGR-----------------------------------RQPGSFFR GNSTRLLNGYKPAVTTQFHL-------PSR------------------------------ -S------KNQVISNTGSSDKTHSTLTERSQNQ-------ETSNPSDPKSSKSTSRS--- -----------------------------------------------------TLD---- -------------------------------------------------------SQTT- -------------------------------------------------------SDSSV FDKSQPA----------------------------------------------------- ------------SESR-------------------------------------------- ---------------------------S-------------------------------- --------------------------HDSKISQDSQASTSHGSP-IHNLNRDISGSSQSV SERHSSSTSQNNKNSRGSDTSSNRDISPSKRTENTDYTNKDDIESKAEG----------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------------------STL NSRAQTTQDIRE------------------------------------------------ -----------------------------------------EDR-QDESSNKKTVGPRTR ISSSFAERFPWLASQYPG---------RFTS----------------------SSRT--- ---------------------------------------SY---PRQDARTP-------- ------------------------------------------------------LTRVS- ------------------------------------------------------------ ------------------------------------------------------------ ----SSV----------------------------------------------------- -------------------GAG---------------------------RPLLRETPTRV -------------------SGAAGASGVSLKQETTEDLKITSRPDSMKNSVVLNSGKSSL PNQHAVTGDTRNP------------------------ATVSSS----------------- -----------ETF---MSSNSGSLSLEKSSALRDFSEVTHKEMSKSEDNMSENVDTLST ERNGKLTDLTSVQTNP-------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------ASPSV------------------------- ------------------------------------------------------------ ----------------------------HRHEENNESVATKETSSRARAGTSTGISP--- -----------------SIRR------S-------------------------------- ------------------------------------------------------------ -------------------------GVGTNGRV--------------------------- ----------------RSSLIASRQLSGSRLSVRPHLVQN----------S--------- -RLGG-SAPDSS-----STS-----------------SLNMPKPV--------------- ------------------------------------------------------------ -------------------------------------------------LTSASDADRDA TVKDT-ESTGGNAHSR------SSLP-------------SSRDTFR------NQGG---- ---------------RTRYPI-----VRG------------NP----------------- --------NN-------------------------------------------------- -----------------------GGRFKPGN------G------N--------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------GKNGKPNLTAM-------- --SGK-DTTSSHGSNKAVGHKFITGPDGTRWVVDLEKGVLMNQDGQVLQDSQGKAKRVVL GEDGRTIFDHMGSPLVSQEGIALFGHGRDSQPVVNPKDK-VLMIGGKPVLGLD--VPPPK T--STTT----------------------------------T--TT-------------- ------------------------------------------------------------ ------------------------------------------------------LAP--T ----------TTLEP--------------TTDWT--------TED-----------FSTA LPYPTCPPGTFSKTDEFGYPIL-DPEGILDCY--------------------------P- ------------------------EEES-SGMEMDPMLTV---AMMP--DALNLDKD--- ---------------------E--------LL-VQ-TTL-------P-----P---T--- -------TTTIA------------------------------------------TTTT-- TTTTA-------IPTTEPQVRV----------------------S--------------- -----NRGPVSEFDLSGKKRFT--------------------------APFVNYIQKDPG APCSLTEALEYLQVDVLENLMEKDRMAVNQNQPPKRKPQNFTVVAMEGCHSFIILDWAKP LKDDMVSGYMVHSASYDDVLNNRWSSRISNGTHLPVENLKPNS----------------- -------------RYYFKVQAKNVFGLGPFSETLTYVTESDDPLLIDRPPG--------- ------GEPIWIPFTFKYNPVHSSCKGSQYVKRTWYRKFVGVVLCNSLRYKIFMGDGL-R -EPFYSIGDTLGQGEDHCQFVDSHKDGRTGPAYLSETLPSAQGYYRAYRQEPVTFGVIGR RTSHPFVGWYECGVPIPGKW---------------------------------------- ------------------------------------------------------ >ENSPFOP00000019562 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------------MA-------- ---AAARRT---------------LLALFFTFCAPQC----------------------- ------------------------G---------------------WAAEKTL------- -----------------------RPQSGKHTAADKVFRESWEPSIHLDGRPV----DRFV ------------------------------------------------------F-NSNK P-----------------------------------------------SR---------- -----------SHRFTKVNKESRPHSVEDV--------------------------DP-- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------EWINLDGFAVLSHAP------------ ------------------VNNSSAA----------------------------------- ------------------------------------------------------------ --------------------GF-------------------------------------- ------------------VR---TAT-RSNSAAAGRKTRVDRTAQPAGTAF--------- -----------TRTHR---------RAPQSSSGPRQ-------PE-KASP-----GTPL- -LERRRQQR------------TKPQADQRNRQAQKL---TSESV---------------- ---------HVVSLQAQK-----------------ALGQSLPNNGAATAKTSPPEP---- ---PEY-EAQDISVRVMSAKSVLISWVDPAVE-MRK-VDPGAT-RSYTVRFREKGESARW EYKESNQRRIMIDTLSADGMYEFSVRISQGEKQGKWSVSVFQRTPESAPSGPPENFEVKP LRGKGTAVIATWDPPEEPNGRIREYILSYAPAIKPFGMKTITYREGTTKATIDGLTPGER YIFKIRATNRRGMGPQSKAFSVAMPR-----------S-SGTASSLS---------KTK- ------------DTQTT------------------------------------------- --------------SKP---IIEQDTDKK------------------------------- --------------------------------------------------SDLEP----T EVPEGP----------------VTTPK------------------------------PH- ----------NTNRRVRPLSQTRSYHSIFSSIRGSVRNTAN-----------RGSTR--- ------------------------------GAE--REHEEQV------------------ ------------------------------------------------------------ --------DD-------------------------------KKPTTPP------PVVE-- --------------------------------------TTT--VVPETKE---------- -----------------------------------LDN---------------------- ----------------------DV------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------SP----- ------------------------------------------------------------ --------------LSEEEVDYDVEPLTTETPSLKVLTP--------------------- ----------------------------------------STTKSAFK------------ ------------------------------------------------------------ ---------------------------------RPYRPN--------------------- ------------------------------------------------------------ -------------------------------R---------------------------- ---------------------------------------------------RP------I KIRVH--------------------------------------------------QKTG- ------------------------SKSTY------------------------------- ----------------------------------------------------------SV S------------------SAD---S---------------------------------- ------------------------------------------------SS--------SS S--------------------SSS------------------------------------ -----------------------------TSSSSSSATSPVSSSSENSFSSSSRSSL--- ------------------------------------------------------------ ---SHTSLLPSSHVPESEPSKKD------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ NIESTNHETAKIHQKPNLTSTRNSLTHGKPLVVVNSQETESAP--TDTS----------- -------------------------------------SSIAE------------------ ---------------------------------------RSS------------------ ------------------------------------------------------------ ---------------------------------------------------NAG------ ------------------------------------------------------------ --------------------------------------------------------SRFG --------------------------------------SR-------------------- ------------FGHGR-----------------------------------RQPGSFFR GNSTRLLKGYKPAVTTQFHL-------PSQ------------------------------ -S------KNQVISNTGSSDKTHSTLTERNQNQ-------EISNPSDPKSSKSTSRS--- -----------------------------------------------------TLD---- -------------------------------------------------------SQTT- -------------------------------------------------------SDSSV FDKSQPA----------------------------------------------------- ------------SESR-------------------------------------------- ---------------------------S-------------------------------- --------------------------HDSKISQDSQASTSHGSP-IHNLNRDISGSSQSV SERHSSSTSQNNKNSRGSDTSSNRDISPSKRTENTVYTNKDDIESKAEG----------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------------------STL NSRAQTTQDIRE------------------------------------------------ -----------------------------------------EDR-QDESSNKKTVGPRTR ISSSFAERFPWLASQYPG---------RFTS----------------------SSRT--- ---------------------------------------SY---PRQDARTP-------- ------------------------------------------------------LTRVS- ------------------------------------------------------------ ------------------------------------------------------------ ----SSV----------------------------------------------------- -------------------GAG---------------------------RPLLRETPTRV -------------------SGAAGASGVSLKQETTEDLKITSRPDSMKNSVVLNSGKSSL PNQHAVTGDTRNP------------------------ATVSSS----------------- -----------ETF---MSSNSGSLSLEKSSALRDFSEVTHKEMSKSEDNMRENVDTLST ERNGKLTDLTSVQTNP-------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------ASPSV------------------------- ------------------------------------------------------------ ----------------------------HRHEENNESVATKETSSRARAGTSTGISP--- -----------------SIRR------S-------------------------------- ------------------------------------------------------------ -------------------------GVGTNGRV--------------------------- ----------------RSSLIASRQLSGSRLSVRPHLVQN----------S--------- -RLGG-SAPDSS-----STS-----------------SLNMPKPV--------------- ------------------------------------------------------------ -------------------------------------------------LTSASDADHDA TVKDT-ESTGGNAHSG------SSLP-------------SSRDTFR------NQGG---- ---------------RTRYPI-----VRG------------NP----------------- --------NN-------------------------------------------------- -----------------------GGRFKPGN------G------N--------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------GKNGKPNLTAM-------- --SGK-DTTSSHGSNKAVGHKFITGPDGTRWVVDLEKGVLMNQDGQVLQDSQGKAKRVVL GDDGRTIFDHMGSPLVSQEGIALFGHGRNSQPVVNPKDK-VLMIGGKPVLGLD--VPPPK T--STTT----------------------------------T--TT-------------- ------------------------------------------------------------ ------------------------------------------------------LAP--T ----------TTLEP--------------TTDWT--------TED-----------FSTA LPYPTCPPGTFSKRDEFGYPIL-DPEGILDCY--------------------------P- ------------------------EEES-SGMEMDPILTV---AMMP--DALNLDKD--- ---------------------E--------LL-VQ-TTL-------P-----P---T--- -------TTTIA------------------------------------------TTTT-- TTTTA-------IPTTEPQVRV----------------------S--------------- -----NRGPVSEFDLSGKKRFT--------------------------APFVNYIQKDPG APCSLTEALEYLQVDVLENLMEKDRMAVNQNQPPKRKPQNFTVVAMEGCHSFIILDWAKP LKDDMVSGYMVHSASYDDILNNRWSSRISNGTHLPVENLKPNS----------------- -------------RYYFKVQAKNVFGLGPFSETLTYVTESDDPLLIDRPPG--------- ------GEPIWIPFTFKYNPVHSSCKGSQYVKRTWYRKFVGVVLCNSLRYKIFMGDGL-R -EPFYSIGDTLGQGEDHCQFVDSHKDGRTGPAYLSETLPSAQGYYRAYRQEPVTFGVIGR RTSHPFVGWYECGVPIPGKW---------------------------------------- ------------------------------------------------------ >ENSPKIP00000006390 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------------MS-------- ---PATVRT---------------LLCLLLSLIALIL----------------------- ------------------------G---------------------VAGLRPL------- -----------------------KPTNVKLTVIDEGLRVTWGPPDELDSRPV----DWYN ------------------------------------------------------I-GYGT A-----------------------------------------------MK---------- -----------TLRFVKVDKDERSQVLEDV--------------------------EPGV LHFLKMTAENAD--------GMSKPVYKAETPKAKSQERRRPTEEIREKLDSPRNVALGS NRGYLLGLAQSDHRLLDKPRPLGRRSQRP------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------HQL---ASESV---------------- ---------YVVSLQAQN-----------------APRQSSSAYSAVMTKKKLAEP---- ---EELPEAKDITVRVNSPQSVMVSWVDPATD-RERSSDNSRE-WLYTVRYREKGESARW DYKETPQRRLLVDGLFADHMYEFSVRISEGLRHGPWSASVFQRTPESAPTGSPTNFHVKP LRGKGTAVTATWEPPEEPNGRLREYILTYAPALKPFGAKSITYPGSQTSASIDGLQPGDS YIFKIRAVNRRGQGPPTKAFSIAMPT-----------T-SAVASSQQ--------TKSQ- ------------ENDRS------------------------------------------- --------------SHLSSRTSKQSSKDS-----------K------------------- -------------------------------------------------DDGLQS----T EETDEPAPYS-----------------------------------------------PKT --------VNPMARRSRPLSQSRSYHSVFSSARSLVRNGAS------------------- ------------------------------------------------------------ PLQDKRDQ---------------------------------------------NNKDHTS HKESSDELEED------------------------------------------------- --------------LDEE-----DTENRKQTVTQNN------------------------ ------------------------------------------------------------ --------DKSSSKNPAYGS--DT------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------SP----- --------HDTS------------------------------------------------ ------PSRSHA-------------------------TPV----------KPWPGSVPRV PFHTRIIP------------AANSQTDVGMESVKPRRLP-TPT----------------- ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------RKSTTHV------------- -------------------------------A---------------------------- ---------------------------------------------------SP------- ------------------------------------------ERVD-------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------------TS S----------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------PSSNNQDVSLSRKDYTANAHPDKKE-------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------SLQITP----------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------NQETSSKLNQAP SIQTQGGNH------------------------------------------HAG------ ----------SG------LV---------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ --------------LSR-----------------------------------RKP----- -----------------------------------FGPMRNTSRVFHGQRKPV------- ----------------SSSAASQSTLPTGIQN---------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------PQS--------------------------------------------- ---------------------------S-------------------------------- -------------------------SHAL------------------------------- --------------------------------------IKNDV----------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------KVE------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------GNNQDY--------------------------------------- ------------------------------KDTEG------------------------- ------------------------------------------------------------ -----------------VIKDERPTAA--------------------------------- -------SHASTLHSLSSPVSKDGKD-------------GQESR---------------- --------------------------------------------TKEYNY---------- ------------------------------------------------GSYP-------- ------------------------------------------------------FSRTNS S---------------------------------------TSMGRGYRLGVSNRTLPRVS SSRD------KS------------------------------------------------ ---APSV----------------------------------------------------- -------------------GAN---------------------------RPVLKETSSH- -------------------------SGISMPRQTSSDL---------------------L PSKHLSTSGASKPSLPNWSSVLSGSANSVKSPSSRGNTESSDSS---------------- --------------------------TKKSG---------------SENG-NENSDN--- --------------------------------VHHGNKETSEKNYK-------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------I------ --------------------------TTTSAPQSATSAASKASRPQSNDNESIDRD-SS- ------------PRKGSSTVPL-------------------------------------- -----------------LPRR------P-------------------------------- ------------------------------------------------------------ -------------------------LVGPNGRF--------------------------- ----------------RSPLLQNRQL-SLRLPTRLLPSQHTQSSGSISESS--------- -RLPS-SSGTGTSS---HVM-----------------SSQLPH----------------- ---SAS------------------------------------------------------ ----RQTSSEGAGPSSVAKQSQPSDT---------------------------------- -------------------------------------------SLRQP----IQGT---- ---------------RLRYP---------------------------------------- ------------------------------------------------------------ -----------SRMDISSRGK------KNGN------E------Q--------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------GKNGRPNLTVA-------- --NGK-DAPTSDNSNKPGGQRIITGPEGTKWIVDLNKGLLMNENGQILQDSEGRPHRVVL GEDGQTIFDSQGSPLVNQEGLALFGHGRDSRPVVNPKDK-MLTLGGKPLIGLD--RPKLR T--T-TV----------------------------------Q--TTT------------- --------T--------------------------------------------------- ------------------------------------------------------------ -------------EL---------TTLPTTTEMTTVEPTMKLTVE-----------PTTI AVHPTCPPGTYSKSDARGFPLL-DMDGILNCY--------------------------P- ------------------------EEGA-SGMDVDAVVTVPVSTHRP--GTLAVVEE--- ---------------------D--------FV-MQ-TTL-------A-----S---T--- -------TA--------------------------------------------------- ------------APVIQSATKP----------------------L--------------- -----NSGPSSTFDAAGNERFT--------------------------APYVSYIRKDPG APCSLTEALEYVQVDVLENLLAMDNQA--HNLPPRNKPHNITVVAMEGCHSFVILDWARP LKDDMVSGYMVYSASYDDVLSNRWSSATSTGTHLPVENLKPNS----------------- -------------RYYFKVQAKNIFGMGPISDTLTYVTESDDPLLIERPPG--------- ------GEPIWIPFSFKYNTAQSTCKGSQFVKRTWYRKFVGVVLCNSLRYKIFMGEGL-K -DTFYSIGDTFGFGEDHCQFVDSYLEGRTGPHSLSEFLPTTQGFYRSYRQEPVRFGPIGQ RTPHTFVGWYECGVPIPGKW---------------------------------------- ------------------------------------------------------ >ENSLOCP00000019951 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------------MS-------- ---PTTEWT---------------LFVLFIPLFALSS----------------------- ------------------------T---------------------VKAERPL------- -----------------------RPKNVKLMPDEKGLRVTWELPRDSQSRPV----EHYN ------------------------------------------------------I-GYGK S-----------------------------------------------MK---------- -----------TLRYIKVGKNTQSQVLEDV--------------------------EPGV LHFLKMTAENSD--------GVSQPVYKAETP---------------------------- ----------------------------PETKVPGRPLQVKGHTSEDSVSV--------- ---------------------------------QW------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------KPPHSSGPDN-------PG-RVRSYVLGVG---- -EDNKRMHY------------TSLQDDQTTHETRRL---ASESV---------------- ---------YVVSLQAQN-----------------ALGQSSPVYRPVMTKKKASDS---- ---EELPEAKDITVRIISPQSVLVTWIDPAFE-KQKDVVSASS-RHYTVRYREKGESARW DYKESTQRRALIENLIADTMYEFSVRISKRERNGKWSVSVFQRTPESAPTSAPENFYVEP LKGKGTAATASWDPPQETNGRIREYILSYAPALKPFGTKSITYPGTTSSAIIDGLQPGDR YIFKIRAANRRGQGPQSKAFSVAMPT-----------T-STIGSS--------------- ------------------------------------------------------------ ------------------------SSQHS-----------KVPDGRKKSTFRTSSNPASS SKVPWSH------------------------------------STSKLPETGSRF----T EEPEEPDSYTPV---------KASSPKPGTSHSSQNKDNETKD---------LIGQGP-- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ HSDSDENLEEE------------------------------------------------- --------------VDEH-----FEEKRVQHTKQNNAATTS------------------- ------------------------------------DD---------------------S SSESSFKSDKIS------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------PGSVSK- --------------------------------TRPQRPI-SPT----------------- ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------NTGTNKM------------- -------------------------------R---------------------------- ---------------------------------------------------RP------- ----------------------------ATLPKAISPSKISKEKED-------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------------PP S----------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------TKSNAQESDFTRKIHTDSSYPNRREPDDHDKEKVPSFPSSKNFFSK----- ------------KPLNSSVLFPKGGRVAVPANRQMGSGFINGRRPV-------------- ------------------------------------------------------------ ----------------------------------GSQSR--------------------- ------------------------------------------------------------ ---------------------------------------------------PS------- -----------------YTESR------------GSAQPETTP----------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------EQIGS------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------SRILNSRLKPD------- ----------------LSSTVSQSTLSTGAQN---------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------PQSR-------------------------------------------- ---------------------------S-------------------------------- -------------------------SH--------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -SQHL-----TKP----------------------------------------------- ------------------------------------------------------------ -----------------------------------------QDNYQDNESTETETEEKKS ASSLSYSTPSPDYDRGAQTSRLGTKEFVTSNDKHSSSPSTGTHTEAKILTSERTRSPSLS SNRFSVLRRHFPKQETKLNTSSGQRRVPSSSTRSQTSESNVAHTDSGASVTQETNEKPKV PISFPSEH----------------ASTG-------------------------------- -SSKRHPAVISESSNPVIPSDSSSSPPSQ------------------------------- ----------------------------------------------------GHLDSDNP IHPKSK-----------------------------------------DEDD--------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------DYDYYGSKELYDTTDKLV------ --------------------------STTAEPQVTTSFLRKPQKP-------------N- ------------PRFGKAHLPFVQS----------------------------------- -----------------VPQR------P-------------------------------- ------------------------------------------------------------ -------------------------AGGFNGKS--------------------------- ----------------RSPMFINRQS-GSRDSESLLPSDY----------S--------- -KLPY-VTSSHTSSERQHTA-----------------SSSVPR----------------- ---TSS------------------------------------------------------ ----SQSSS----------ASLPHLP---------------------------------- -------------------------------------------PIREP----NQGT---- ---------------RVRYP---------------------------------------- ------------------------------------------------------------ -----------GRMDVATRVKTPSSALKPSY------T------Q--------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------GKNGRPNLTNT-------- --NGK-VVSTSDAKVKQGGRRLITGPEGVKWIVDFDKGFLMNQEGRILQDSKGRPRRVVL GEDGRTIFDDQGTPLVSPDGLALFGHGRDSRPVVNPKDK-LLAVGGKPLVGLDPIKPTQK M--T-TT----------------------------------T--TTT------------- --------TT-----------TTT------------------------------------ -----------------------------------------------------TAAT-TT ----------TTPEP---------TTIPTTTEMT--------TEE-----------STTP FIFPTCPPGTYSQVDERGYPLL-GEDGILDCY--------------------------P- ------------------------EEFQ-------------------------------- -------------------------------F-VQ-TTL-------S-----P---T--- -------T---------------------------------------------------- -----------------TPTTPTTRESPEATTTETEEVYTEAMHF--------------- -----NNGPTSGFDAAGNPRFT--------------------------APYVNYIQKDPG APCSLTEALEYLQVDVLENLFEKDRQS--THQPPKSKPHNITVVAMEGCHSFVILDWARP LKDDMVSGYMVHSASYDDVLNNRWSSSSANGTHLPVENLKPNS----------------- -------------RYYFKVQAKNIFGLGPLSETFTYETESDDPLLIERPPG--------- ------GEPIWIPFSFKYNPAQSTCKGSQYVKRTWYRKFVGVVLCNSLRYKIFMGEGL-K -ETFYSIGDTYGHGEDHCQFVDSHMEGRTGPHYLSTYLPTVQGFFRAYRQEPVQFGLIGR RTSHPFVGWYECGVPIPGKW---------------------------------------- ------------------------------------------------------ >ENSAOWP00000010743 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------------M-------- --RWSRPSFTFFLCVIEVRALSYTPDQHASFQAIGYSKVGKFPSVSL---SLSLI----- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------PLRVRAQSP-------------------------------------- -----------------DGRLSFRWKPPYG-AGFRG-------PRSRSQGYLRGYE---- -ESSRRMSY------------APLLQERQNQEAKKL---ASESV---------------- ---------HVVSLPSRN-----------------SQGRSQPVYRSSLTKRKATEE---- ---EEVEVAQDISVRVMSSQSVLVAWTDPLYE-KQKRVA--AN-RQYNVRYREKGESARW DYKRVSHRRALVENLMPDTMYEFAVQILEGEKEGKWSASVYQRTPEAAPASAPENLDVWP LKGKPTSVAASWDALPESEGKVKEYILSYAPALKPFGAKSVTYSGATTSAIIDGLQSGER YIFKIRAANRRGQGPQSKAFSVAIP----------------------------------- ------------------------------------------------------SSSV-S LKIQPSLSSKHSS-VHSPSVS--------------------------------------- ---------------GKKSLLSEYKNKILA-GGVLNKSQLPSRKAGEL-EPDLQS----T EVTD---------DNDSSHEAPTPPPK-------------AQD----------------- -----------QRSVVRPLPPSRPVHPVLDSGRNPVQTHASEGSRQTSTGK-REPL---- --------------------------------------------ALLP-----------S STQR---------------------------------------SSASSFSKYTDN----- --------ETKQLRQSNANI----------------------------------PSP--- -------------------------------------------------------KTSSH ALPAKNNDL--------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------AHGSYTEYDSEEAEGRAEQSSSRL Q----------QTRLPSASNFHMWKDSKLAAVA--------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------VSSRSGI------SGHTSPHSRSFTSAKSDGKDGDK NYGEGSQDE------KSLSAAIAHNP-S------------L-----------------SA S------------------RQSSS-AIYSKKRNPQVDSDSHLTDTHSEKS---------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------P---RSDS-EEHQSRAAAPE----------KHSPLQSSLSKHKPEEQD SREVKETLAQSKPSLSLPEKTFPSHL-------------------------P-------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------SQKSSRSEALQ-KAQT----------------- ------------------------------------------------------------ ---------------------------------------------------SPS------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------LLHSR-------------------- ---------------GR-----------------------------------RLPS---- ---------------------------P-------------------------------V SS---------------------------------------------------------- --------------------QSNEEL---QEN---------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ED---------------------------------------------------------- ----------ED------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------------VAKDSDRAST WSVSPKEVSTSRGLPASFSRGSSSLSLLNQQQS--------------------------- ------GSQA-------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ----------------------ASYKSKLSQPDSS------------------------- ------------------------------------------------------------ ----------------------------SASDTVKDHQ---------------------- -----------------------------------------------------------Y NPRLSSP----------SLRQTRPS----------------------------------- ------------------------------------------------------------ ----L-----------P-------------------------------------TR---- ------------------------------------------------SRVA-------- -------------------------------------------------------TRTVP Q-TEKKYGLLPSKI--SKLELPQKVPSFSSS----------------------------- ----------KSRQSGSNEEDDY---YSEYDQKESEE---------------KSTSPLAA KW-SPSV-SRGNKNTYD------------------------------DATSDRRKSMDTL L-------------------------------------------------------PHKV ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------------R S----------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------KEEEKE------- ------------------------------------------------------------ ---------------------------------------KTPTL---------------- ----------------------------------------------------------KI HSPES------------------------------------------------------- ------------------------------------------------------------ ---------------------------P-------------------------------- ------------------------------------------------------------ ------------------------------G------------------SS--------- -----------------------------------------------AIAS--------- -RIPH------------P-PNK-HTPSKPSFA--------WPHS---------------- ---SASTT-------THSVSPTV------------------------------------- ----SSS----------------------------------------------------- -------------------------------TL----------SPHQRLLN--------- ----S----------RLRSPS-----QRH-------------FV---------------- ------------------------------------------------------------ ---------------------------RPSY------R------Q--------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------GYNGRPNLTTK-------- NGNGK---ILPGNNGKPSGQRIINGPQGTKWIVDLDRGLVLNVEGKYLQDSQGNPLRVKL GGDGRTIVDEKGAPMVSPDGLPLFGHGRFSKPVASAQDKPIISLGGKPLIGLE--MIKKT TTPS-TT---------------------TTTIP--------P--TTT---------T--- --------TT-----------TTT------------------------------------ --------------------------------TTT------------------TTT--TT ----------TTPEP-------------TTTE------------------------PPTE KPPPTCPPGTYAQYDDEGSLVL-GFDGLPECN---------------------------- ---------------LTFSFYVSSE----------------------------------- ---------------------D--------YEFFE-STL-------P-----P---T--- -------TTTVT-------------------------------------------TTT-- TS------TTTESEIVYPETSV----------------------V--------------- -----GNSPVSEYDIAGKKRFT--------------------------APYVTYLNKDPT VPCSLTEALEHFQVESLDEIIPND-FLKEKDLRPLKAPHNITIVAVEGCHSFVIVDWAKS AQGDMVTGYLVYSASYDDFLKNKWSTRTAGTTHLPIENLKPNT----------------- -------------RYYFKVQAKNPFGYGPVSSSVSFITESDNPLLIVRPPG--------- ------GEPIWIPFTFKYDPTYSDCSGKQYVKRTWYRKFVGVVLCNSLRYKIYLSDDL-K -DTFYSIGDSWGRGEDHCQFVDSHMDGRTGPQSYVEALPTIRGYYRQYRQEPVSFGRIGH TTPYYYVGWYECGVPIPGKW---------------------------------------- ------------------------------------------------------ >ENSARWP00000012208 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------------------VYGE STLTT------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -CNR------LIGTAIHATCFIVIMMGF-------------------------------- ------------------------------------------VCLFAFFFE--------- ------------------------------------------------------------ ------------------------------------------------------------ ------DKDMPNRPLRVRAQSP-------------------------------------- -----------------DGRLSFRWKPPYG-AGFRG-------PRSRSQGYLRGYG---- -ESSRRMSY------------APLLQERQNQEAKKL---ASESV---------------- ---------HVVSLPSRN-----------------SQGRSQPVYRSSLTKRKATEE---- ---EEVEVAQDISVRVMSSQSVLVAWTDPLYE-KQKRVA--AN-RQYNVRYREKGESARW DYKRVSHRRALVENLMPDNMYEFAVQILEGEKEGKWSASVYQRTPEAAPASAPENLDVWP LKGKPTSVAASWDALPESEGKVKEYILSYAPALKPFGAKSVTYSGATTSAIIDGLQSGER YIFKIRAANRRGQGPQSKAFSVAIPA-----------D-VHEDLIAQQQANIQDNSKAKK TGNAG--------------------------------------------SSPSQSSSV-S SKIQPSLSSKHSS-VHSPSVS--------------------------------------- ---------------GKKSLLSEYKNKILA-GGVLNKSQLPSRKAGEL-EPDLQS----T EVTD---------DNDSSHEAPTPPPK-------------AQD----------------- -----------QRSVVRPLPPSRPVHPVLASGRNPVQTHASEGSRQTSTGK-REPL---- --------------------------------------------ALLP-----------S STQR---------------------------------------SSASSFSKYTDN----- --------ETKQPRQSNANI----------------------------------PSP--- -------------------------------------------------------KTSSH ALPAKNNDL--------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------AHGSYTEYDSEEAEGRAEQSSSRL Q----------QTRLPSASNSHMWKDSKLAAVA--------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------VSSRSAI------SGHTSPHSRSFTSAKSDGKDGDK NYGEGSQDE------KSLSAAIAHNP-S------------L-----------------SA S------------------RQSSS-AIYSKKRNPQVDSDSHLRDTHSEKS---------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------P---RSDS-EEHQSRAAAPE----------KHSPLQSSLSKYKPEEQD SQEVKETLAQSKPSLSLPKKTFPSHL-------------------------P-------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------SQKSSRSEALQ-KAQT----------------- ------------------------------------------------------------ ---------------------------------------------------SPS------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------LLHSR-------------------- ---------------GR-----------------------------------RLPS---- ---------------------------P-------------------------------V SS---------------------------------------------------------- --------------------QSNEEL---QEN---------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ED---------------------------------------------------------- ----------ED------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------------VAKDSDRAST WSVSPKDVSTSRGLPASFSRGSSSLSLLNQQRS--------------------------- ------GSQA-------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ----------------------ASYKSKLSQPDSS------------------------- ------------------------------------------------------------ ----------------------------SASNTVKDHQ---------------------- -----------------------------------------------------------Y NPRLSSP----------SLRQTRPS----------------------------------- ------------------------------------------------------------ ----L-----------P-------------------------------------TR---- ------------------------------------------------SRVA-------- -------------------------------------------------------TRTVP Q-TEKKYGLLPSKI--SKLELSQKVPSFSSS----------------------------- ----------KSRQSGSNEEDDY---YSEYDQKESEE---------------KSTSPLAA KW-SPSV-SRGNKNTYD------------------------------DTTSDRRKSMDTL L-------------------------------------------------------PHKV ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------------R S----------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------KEEEKE------- ------------------------------------------------------------ ---------------------------------------KTPTL---------------- ----------------------------------------------------------KI HSPES------------------------------------------------------- ------------------------------------------------------------ ---------------------------P-------------------------------- ------------------------------------------------------------ ------------------------------G------------------SS--------- -----------------------------------------------AIAS--------- -RIPH------------P-PNK-HTPSKPSFA--------WPHS---------------- ---SASXT-------THSVSPTV------------------------------------- ----SSS----------------------------------------------------- -------------------------------TL----------SPHQRLLN--------- ----S----------RLRSPS-----QRH-------------FV---------------- ------------------------------------------------------------ ---------------------------RPSY------R------Q--------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------GYNGRPNLTMK-------- NGNGK---ILPGNNGKPSGQRIINGPQGTKWIVDLDRGLVLNVEGKYLQDSQGNPLRVKL GGDGRTIVDEKGAPMVSPDGLPLFGHGRFSKPVASAQDKPIISLGGKPLIGLE--MIKKT TTPS-TT---------------------TTTIP--------P--TTT---------T--- --------TT-----------TTT------------------------------------ --------------------------------TTT------------------TTT--TT ----------TTPEP-------------TTTE------------------------PPTE KPPPTCPPGTYAQYDDEGSLVL-GFBGLPECN--------------------------AE ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------GNCPSVYFSADIYKLLTKCHPSLSLPAPYVTYLNKDPT VPCSLTEALEHFQVESLDEIIPND-FLKEKELRPLKAPHNITIVAVEGCHSFVIVDWAKP AQGDMVTGYLVYSASYDDFLKNKWSTRTAGTTHLPIENLKPNT----------------- -------------RYYFKVQAKNPFGYGPVSSSVSFITESDNPLLIVRPPG--------- ------GEPIWIPFTFKYDPTYSDCSGKQYVKRTWYRKFVGVVLCNSLRYKIYLSDDL-K -DTFYSIGDSWGRGEDHCQFVDSHMDGRTGPQSYVEALPTIRGYYRQYRQEPVSFGRIGH TTPYYYVGWYECGVPIPGKW---------------------------------------- ------------------------------------------------------ >ENSAHAP00000025919 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------I-VYGE STLTTLS---------------------------------------LIL----------- ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------------I W------------TAIHATCFIVIMMGF-------------------------------- ------------------------------------------VCLFAFFFE--------- ------------------------------------------------------------ ------------------------------------------------------------ ------EKDMPNRPLRVRAQSP-------------------------------------- -----------------DGRLSFRWKPPYG-AGFRG-------PRSRSQGYLRGYE---- -ESSRRMSY------------APLLQERQNQEAKKL---ASESV---------------- ---------HVVSLPSRN-----------------SQGRSQPVYRSSLTKRKATEE---- ---EEVEVAQDISVRVMSSQSVLVAWTDPLYE-KQKRVA--AN-RQYNVRYREKGESARW DYKRVSHRRALVENXMPDTMYEFAVQILEGEKEGKWSASVYQRTPEAAPASAPENLDVWP LKGKPTSVAASWDALPESEGKVKEYILSYAPALKPFGAKSVTYSGATTSAIIDGLQSGER YIFKIRAANRRGQGPQSKAFSVAIPA-----------D-VHEDLIAQQQANIQDNSKAKK TGNAG--------------------------------------------SSPSQSSSV-S LKIQPSLSSKHSS-VHSPSVS--------------------------------------- ---------------GKKSLLSEYKNKILA-GGVLNKSQLPSRKAGEL-EPDLQS----T EVTD---------DNDSSHEAPTPPPK-------------AQD----------------- -----------QRSVVRPLPPSQPVHPVLDSGRNPVQTHASEGSRQTSTGK-REPL---- --------------------------------------------ALLP-----------S STQR---------------------------------------SSASSFSKYTDN----- --------ETKQLRQSNANI----------------------------------PSP--- -------------------------------------------------------KTSSH ALPAKNNDL--------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------AHGSYTEYDSEEAEGRAEQSSSRL Q----------QTRLPSASNFHMWKDSKLAAVA--------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------VSSRSGI------SGHTSPHSRSFTSAKSDGKDGDK NYGEGSQDE------KSLSAAIAHNP-S------------L-----------------SA S------------------RQSSS-AIYSKKRNPQVDSDSHLTDTHSEKS---------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------P---RSDS-EEHQSRAAAPE----------KHSPLQSSLSKHKPEEQD SREVKETLAQSKPSLSLPEKTFPSHL-------------------------P-------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------SQKSSRSEALQ-KAQT----------------- ------------------------------------------------------------ ---------------------------------------------------SPS------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------LLHSR-------------------- ---------------GR-----------------------------------RLPS---- ---------------------------P-------------------------------V SS---------------------------------------------------------- --------------------QSNEEL---QEN---------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ED---------------------------------------------------------- ----------ED------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------------VAKDSDRAST WSVSPKEVSTSRGLPASFSRGSSSLSLLNQQQS--------------------------- ------GSQA-------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ----------------------ASYKSKLSQPDSS------------------------- ------------------------------------------------------------ ----------------------------SASDTVKDHQ---------------------- -----------------------------------------------------------Y NPRLSSP----------SLRQTRPS----------------------------------- ------------------------------------------------------------ ----L-----------P-------------------------------------TR---- ------------------------------------------------SRVA-------- -------------------------------------------------------TRTVP Q-TEKKYGLLPSKI--SKLELPQKVPSFSSS----------------------------- ----------KSRQSGSNEEDDY---YSEYDQKESEE---------------KSTSPLAA KW-SPSV-SRGNKNTYD------------------------------DATSDRRKSMDTL L-------------------------------------------------------PHKV ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------------R S----------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------KEEEKE------- ------------------------------------------------------------ ---------------------------------------KTPTL---------------- ----------------------------------------------------------KI HSPES------------------------------------------------------- ------------------------------------------------------------ ---------------------------P-------------------------------- ------------------------------------------------------------ ------------------------------G------------------SS--------- -----------------------------------------------AIAS--------- -RIPH------------P-PNK-HTPSKPSFA--------WPHS---------------- ---SASTT-------THSVSPTV------------------------------------- ----SSS----------------------------------------------------- -------------------------------TL----------SPHQRLLN--------- ----S----------RLRSPS-----QRH-------------FV---------------- ------------------------------------------------------------ ---------------------------RPSY------R------Q--------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------GYNGRPNLTTK-------- NGNGK---ILPGNNGKPSGQRIINGPQGTKWIVDLDRGLVLNVEGKYLQDSQGNPLRVKL GGDGRTIVDEKGAPMVSPDGLPLFGHGRFSKPVASAQDKPIISLGGKPLIGLE--MIKKT TTPS-TT---------------------TTTIP--------P--TTT---------T--- --------TT-----------TTT------------------------------------ --------------------------------TTT------------------TTT--TT ----------TTPEP-------------TTTE------------------------PPTE KPPPTCPPGTYAQYDDEGSLVL-GFDGLPECN--------------------------AE -------------DKIT------------------------------------------- -------------------------------------TL-------P-----P---T--- -------TTTVT-------------------------------------------TTT-- TS------TTTESEIVYPETSV----------------------V--------------- -----GNSPVSEYDIAGKKRFT--------------------------APYVTYLNKDPT VPCSLTEALEHFQVESLBEIIPND-FLKEKDLRPLKAPHNITIVAVEGCHSFVIVDWAKS AQGDMVTGYLVYSASYDDFLKNKWSTRTAGTTHLPIENLKPNT----------------- -------------RYYFKVQAKNPFGYGPVSSSVSFITESDNPLLIVRPPG--------- ------GEPIWIPFTFKYDPTYSDCSGKQYVKRTWYRKFVGVVLCNSLRYKIYLSDDL-K -DTFYSIGDSWGRGEDHCQFVDSHMDGRTGPQSYVEALPTIQGYYRQYRQEPVSFGRIGH TTPYYYVGWYECGVPIPGKW---------------------------------------- ------------------------------------------------------ >ENSDNVP00000005888 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------------M-------- --RWSRRSFTFFLCVIEVRALSYTPDQHASSLAIGYSKVGKFPSVSLLTKK--------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------EKDMPNRPLRVRAQSP-------------------------------------- -----------------DGRLSFRWKPAYG-AGFRG-------PRSRSQGYLRGYG---- -ESGRRMSY------------APLLQERQNQEAKKL---ASESV---------------- ---------HVXSLPSRN-----------------FQGRSQPVYRSSLTKRKVTEE---- ---EEVEVAQDISVRVMSSQSVLVAWTDPLYE-NQKRVA--AN-RQYNVRYREKGESARW DYKQVPHRRALVENLMPDTMYEFAVQILEGEKEGKWSVSVYQRTPEAAPASAPENLDVWP LKGKPTSVAASWDALPESEGKVKEYILSYAPALKPFGAKSITYSGATTSAIIDGLQSGER YIFKIRAANRRGQGPQSKAFSVAIPA---------------------------DNSKAKK TGNSG--------------------------------------------SSSSQSSSV-S SKIQPSLSSKHSS-VHSPSVS--------------------------------------- ---------------NKKSLLSEYKNKLLAGGGVLSKSELPSRESDEL-EPDLQS----T EVTD---------DHDSSHEAPA-PPK-------------AQD----------------- -----------QRSVVRPLPPSRPVHPVLASGRTPVRTHASEGSRQTSTGK-REPL---- --------------------------------------------ALLP-----------S STQR---------------------------------------SSASSVPKYTDN----- --------ETKQLRQSNANI----------------------------------PSP--- -------------------------------------------------------KTSSH ALPAKNNDL--------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------ARGSSVEYDSEEAEGRAEQSSSRL Q----------QTRLPSASSSHMWEDSKLAAVA--------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------VSSRSAV------SGHTSPHSRSFTSARSDGKDGDK NYSEDSQDE------KSLSPAIAHNP-T------------L-----------------SA S------------------RQSSS-AIYSKKRNTHTDSNSHLRDPHGEKS---------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------P---HSDS-EKHQSRAAAPE----------KRSAFQSPLSKHKPEEQD SREVKETLAQSKSSLSLPKKTFPSHL-------------------------P-------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------SQKSSHSEAPQ-RAQT----------------- ------------------------------------------------------------ ---------------------------------------------------SPS------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------LLHSR-------------------- ---------------GR-----------------------------------RLPS---- ---------------------------P-------------------------------V SS---------------------------------------------------------- --------------------QNNEEL---QEN---------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ED---------------------------------------------------------- ----------ED------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------------GAEDSDRASS HSVSPKEVSTSRGLPASFFQRSSSLSLSKQQQP--------------------------- ------GSQA-------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ----------------------PSYKSKLTQPDSS------------------------- ------------------------------------------------------------ ----------------------------SASNTVKDNQ---------------------- -----------------------------------------------------------Y NPRLSSP----------SLRQTRPS----------------------------------- ------------------------------------------------------------ ----L-----------P-------------------------------------TR---- ------------------------------------------------SRVA-------- -------------------------------------------------------TRTVP Q-TEKKYGLLPSKI--SKLELPQKVPSFSSS----------------------------- ----------KSRQSDSNEEDDY---YSEYDQKELEE---------------KSTSPLAE KW-SPSV-SRXDKNTYD------------------------------DTTSNRRKSMDTI L-------------------------------------------------------PHKV ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------------R S----------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------EEEEKE------- ------------------------------------------------------------ ---------------------------------------KTPTL---------------- ----------------------------------------------------------QI SSPES------------------------------------------------------- ------------------------------------------------------------ ---------------------------P-------------------------------- ------------------------------------------------------------ ------------------------------G------------------NS--------- -----------------------------------------------AIAS--------- -RIPH------------P-PNK-HSPSKPSFV--------WPHS---------------- ---SASTT-------THTVSPTV------------------------------------- ----SSS----------------------------------------------------- -------------------------------TL----------SPRQRLLN--------- ----S----------RLRSPS-----QRQ-------------FV---------------- ------------------------------------------------------------ ---------------------------RPSY------R------Q--------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------GYNGRPNLTTK-------- NGNGK---IVPGNNGKPSGQRIINGPQGTKWIVDLDRGLVLNVEGKYLQDSQGNPLRVKL GGDGRTIVDEKGAPVVSPDGLPLFGHGRFSKPVASAQDKPIISLGGKPLIGLE--MIKKT TTPS-TT---------------------TTTMP--------P-TTTT---------T--- --------TT-----------TTT------------------------------------ --------------------------------TTT------------------TTT--TT ----------TTPEP-------------TTTE------------------------PPTE KPPPTCPPGTYAQYDDEGSLML-GFDGLPD------------------------------ --------------KLTFSFYVSSE----------------------------------- ---------------------D--------YELFE-STL-------P-----P---T--- -------TTTVT-------------------------------------------TTT-- TS------TTTEMEIVYPETSV----------------------V--------------- -----GTSPVSEYDIAGKKRFT--------------------------APYVTYLNKDPA APCSLTEALEHFQVESLDEIIPND--LKEKELRPLKAPHNITVVAVEGCHSFVIVDWAKP AQGDMVTGYLVYSASYDDFLKNKWSTKTAGTTHLPIENLKPNT----------------- -------------RYYFKVQAKNPFGYGPVSSSVSFITESDNPLLIVRPPG--------- ------GEPIWIPFTFKYDPTYSDCSGKQYVKRTWYRKFVGVVLCNSLRYKIYLSDDL-K -DTFYSIGDSWGRGEDHCQFVDSHMDGRTGPQSYIEALPTIRGYYRQYRQEPVSFGRIGH TTPYYYVGWYECGVPIPGKW---------------------------------------- ------------------------------------------------------ >ENSNPEP00000009145 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------SSCSLGMPTSLLHRDPFFDLVAHQCLLIGTFHLITCNHDGL------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------CVFALFFE--------- ------------------------------------------------------------ ------------------------------------------------------------ ------GKDLPSRPLRARAQSP-------------------------------------- -----------------DGRSPFRWKPSYG-AGFRG-------PRSRSQGYLRGYG---- -ESSRRMSY------------APLPQERQNQEAKKL---ASESV---------------- ---------HVVSLPSRN-----------------SQGRSQPVYRSSLIKRKVTEE---- ---EEVEVAQDISVRVMSSQSVLVVWTDPLYE-KQ-RVA--AN-RQYNVRYREKGESARW DYKRVPHRRALVENLMPDTMYEFAVQILEGEKEGKWSVSVYQRTPEAAPASAPENLDVWP LKGKPTSVAASWDALPESEGKVKEYILSYAPALKPFGAKSITYSGATTSAIIDGLQAGER YIFKIRAANRRGQGPQSKAFSVAIP-----------------DSIAQQQASIQDNSKAKK PGNAD--------------------------------------------SS--------- ------------------SVS--------------------------------------- ---------------DKKSLLSEYKNKLLAGGGVLSKSQLPSRKTSEL-EPDLQS----T EVTD---------DHDSSHEAPTVPPK-------------AQV----------------- -----------QRNVVRPLSPSRPVHPVLASGRIPVRTHVSEGSRQTSTGK-REPP---- --------------------------------------------ALLP-----------A STQH---------------------------------------SSASSVPKYTDN----- --------ETKQLRQSNSNI----------------------------------PSP--- -------------------------------------------------------KTSSH VLPAKNNDL--------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------TRDSYARHDSEEAEGRAEQSSSRS Q----------QTRLPSTSSSHMWKDSKLAAVA--------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------VSSRSAV------SGHTSPHSHSF-SAKSEGKDGDK N-REGSQDE------RSFSPAIAHNP-S------------L-----------------ST S------------------RQSSS-AIYSKKRNPQIDSNSHLRDTHGEKS---------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------L---HSNS-EDHHSRAAAVE----------KHSPLPSSLSKHKPEEQD SQEVRETLAQSKPSFSLPKKTFPSRL-------------------------P-------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------SQKSSRSEAPQ-RAQT----------------- ------------------------------------------------------------ ---------------------------------------------------SPS------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------LLHSR-------------------- ---------------GR-----------------------------------RLPS---- ---------------------------P-------------------------------V AS---------------------------------------------------------- --------------------RSNEEL---QEN---------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ED---------------------------------------------------------- ----------ED------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------------VEEGRDRAST QSVSPKEVSPSRGLPASFSQGSSSLS--KQQQS--------------------------- ------GSQA-------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ----------------------PSYKSKLAQTDSS------------------------- ------------------------------------------------------------ ----------------------------SSSDTVKENY---------------------- -----------------------------------------------------------Y NPRLSSP----------SLRQTRPS----------------------------------- ------------------------------------------------------------ ----L-----------P-------------------------------------TR---- ------------------------------------------------SRLP-------- -------------------------------------------------------MRT-- ------------GL--SKLEIPQKVPSFSSS----------------------------- ----------KSHQSGSNEEDD----YSEYDQKESEE---------------KSASPLAA KW-SPSV-SRGNKNTYD------------------------------DTTSNRRKSMDTL L-------------------------------------------------------PHKV ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------------R S----------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------EEEEKE------- ------------------------------------------------------------ ---------------------------------------ETPXL---------------- ----------------------------------------------------------KM SSPES------------------------------------------------------- ------------------------------------------------------------ ---------------------------P-------------------------------- ------------------------------------------------------------ ------------------------------G------------------SS--------- -----------------------------------------------AIAS--------- -RIPH------------S-PSK-HIPSKPSFV--------WPRS---------------- ---SASTT-------THTVSPTV------------------------------------- ----SSS----------------------------------------------------- -------------------------------TL----------SPRQRLLN--------- ----S----------RLRSPS-----QRQ-------------FV---------------- ------------------------------------------------------------ ---------------------------RPSY------R------Q--------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------GYNGRPNLTTK-------- NGNGK---ILPGNNGKPSGQRVINGPQGTKWIVDLDRGLVLNVEGKYLQDSQGNPLRVKL GGDGRTIVDEKGAPMVSPDGLPLFGHGRFSKPVASAQDKPIISLGGKPLIGLE--MIKKT TTPS-TT---------------------TTTTT--------PTTTTT---------T--- --------TT-----------TTT------------------------------------ --------------------------------TTT------------------TTT--TT ----------TTPEP-------------TTTE------------------------PPTE KPAPTCPPGTFAQYDEEGSLML-GFDGLPECN--------------------------AE GNFL---------VKLTFSFYVSSE----------------------------------- ---------------------D--------YEFFE-STL-------P-----P---T--- -------TTTVA-------------------------------------------TTT-- TS------TTTELEIVYPETSV----------------------V--------------- -----GTNPVSEYDIAGKKRFT--------------------------APYVTYLNKDPT APCSLTEALEHFQVESLDEIIPND--LKEKELRPLKAPHNITVVAVEGCHSFVIVDWAKP VQGDMVTGYLVYSASYDDFLKNKWSTRTAGTTHLPIENLKPNT----------------- -------------RYYFKVQAKNPFGYGPVSSSVSFITESDNPLLIVRPPG--------- ------GEPIWIPFTFKYDPTYSDCSGKQYVKRTWYRKFVGVVLCNSLRYKIYLSDDL-K -DTFYSIGDSWGRGEDHCQFVDSHMDGRTGPQTYIEALPTIRGYYRQYRQEPVSFGRIGH MTPYYYVGWYECGVPIPGKW---------------------------------------- ------------------------------------------------------ >ENSPMJP00000012117 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------MPSRPLRVRAQSP-------------------------------------- -----------------DGKLPFRWKPPYG-AGFRG-------PRSRSQGYPRGYG---- -ESSRRMSY------------APMPQERQNQEARKL---ASESV---------------- ---------HVVSLPSRS-----------------SQGRSQPVYRSSLTKRKVTEE---- ---EEVEVAQDITVRVMSSQSVLVTWTDPLYE-KR-KVA--AN-RQYNVRYREKGESARW DYKQVSNRRALVENLMPDTMYEFAIQILEGEKEGKWSVSVYQRTPEAAPASAPENLDVWP LKGKPTSVAASWDALPESEGKVKEYILSYAPALKPFGAKSITYSGATTSAIIDGLQAGER YIFKIRAANRRGPGPQSKAFSVAIPA-----------A-AQEDSVAQQKTNIQENSEAKK TGNAG--------------------------------------------LSPPQSSSV-S SKAQLSPSSKQLS-VHSPAVS--------------------------------------- ---------------DKKNLLSEYKNKILTR-GVLSKSQLPSRRTGEL-EPDLQS----T EVTD---------DSDSSQEATASPPK-------------AQD----------------- -----------QRRNVKPLSPSRPVHPVLASGRTSVRTHTSEMSSQTSTEK-REPP---- --------------------------------------------ALLP-----------S SAQQ---------------------------------------SSASSVPRYTDN----- --------ETKQLRQSNTNV----------------------------------PS---- -------------------------------------------------------KTSSH PLPSRNNGLASNVE---------------------------------------------- ------------------------------------------EKPDPML----------- ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------VKVSSKTSEPGHQALPSNRQ SAVSHEGVLGHRSRS--------------------------------------------- -------------------GSLGHSRQAASKSADSHAHDTHNEFDSEEAEDRARQPSSRS Q----------QTRLSSGSSSHTWKDSKSAAVA--------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------VSSRSAV------PGYTSPHSRSSTNAKSKGKDVDK NYREDSQDEN-PLF-----------P-S------------L-----------------PS S------------------RQSSS-AIYSKRRNPQVNSNSHPRDTHGEKS---------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------P---HSDS-EEQQSQTAAPE----------KHSLLQSSLSKYKPEEQG NREVKETLAHSKPREFLPRKTLSSHL-------------------------P-------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------VEKTSHSEPPQ-RAQT----------------- ------------------------------------------------------------ ---------------------------------------------------SPS------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------ILHSR-------------------- ---------------GR-----------------------------------RLPS---- ---------------------------H-------------------------------V SS---------------------------------------------------------- --------------------QSNEEL---QED---------------------------- ------------------------------------------------------------ ------------------------------------------------------------ DD---------------------------------------------------------- ----------ED------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------------GTEGSDRASR RSVFLKEVSSSRGLSASFSQGSSSSSQSKQQHP--------------------------- ------GSQV-------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ----------------------HSNKPKHTGPDSS------------------------- ------------------------------------------------------------ ----------------------------SASDTAKGNH---------------------- -----------------------------------------------------------Y NQRLSPT-----------SRQARPS----------------------------------- ------------------------------------------------------------ ----L-----------P-------------------------------------AR---- ------------------------------------------------SGAT-------- -------------------------------------------------------TRTAS Q-TEKKYGLLPSKL--SNTELPQKVPSPSSS----------------------------- ----------KSHQSVSNEEDDY---YSEYDQKEMEE---------------KPTS-LAA KR-SPSV-SRGSKNVYE------------------------------DTANNKRKSMDTL L-------------------------------------------------------LHKV ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------------S S----------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------EEEEMG------- ------------------------------------------------------------ ---------------------------------------KPSIL---------------- ----------------------------------------------------------KL SSPES------------------------------------------------------- ------------------------------------------------------------ ---------------------------P-------------------------------- ------------------------------------------------------------ ------------------------------R------------------NS--------- -----------------------------------------------DVAS--------- -QITQ------------S-SNK-HTPSKPNFV--------WPRS---------------- ---SASTT-------THTISPAI------------------------------------- -----SS----------------------------------------------------- -------------------------------TL----------SPRQRLLN--------- ----S----------RLGSPS-----QRQ-------------FV---------------- ------------------------------------------------------------ ---------------------------RPPY------R------S--------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------GHNGRPNLTTK-------- NGNGK---VIPGNNGKPSGQKVINGPQGAKWIVDLDRGLVLNAEGKYLQDSQGNPLRVKL GGDGRTIVDEKGAPVVSPDGLPLFGHSRFNKPVASAQDKPIISLGGKPLIGLE--MIKKT TTPS-TT---------------------TTTIP--------T--TTT---------T--- --------TT-----------TTT------------------------------------ --------------------------------TTT----------------VATTT--TT ----------TTPEP-------------TTTD------------------------PPTE KPAPTCPPGTYGQYDDEGNLLL-GFDGLPECN--------------------------A- ------------------------E-DTFSGLDSDV-------TATP--EAYVIYDD--- ---------------------D--------YEFFE-STL-------P-----P---T--- -------TTTVT-------------------------------------------TTT-- AP------TTTELEVIYPETSV----------------------V--------------- -----GTGPVSEYDIAGKKRFT--------------------------APYVTYLNKDPA APCSLTEALEHFQVESLDEIIPND--FREKDQRPLKAPHNITVVAVEGCHSFVIVDWAKP AQGDMVTGYLVYSASYDDFLKNKWSTRTAGSTHLPIENLKPNT----------------- -------------RYYFKVQAKNPFGYGPVSSSVSFITESDNPLLIVRPPG--------- ------GEPIWIPFTFKYDPTYSDCTGKQYVKRTWYRKFVGVVLCNSLRYKIYLSDDL-K -DTFYSIGDSWGRGEDHCQFVDSHLDGRTGPQSYIEALPTIRGYYRQYRQEPVSFGRIGY TTPYYYVGWYECGVPIPGKW---------------------------------------- ------------------------------------------------------ >ENSCCEP00000010856 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------MPSRPLRVRAQSP-------------------------------------- -----------------DGKLPFRWKPPYG-AGFRG-------PRSRSQGYPRGYG---- -ESNRRMSY------------APMPQERPNQEARKL---ASESV---------------- ---------HVVSLPSRS-----------------SQGRSQPVYRSSLTKRKVTEE---- ---EEVEVAQDITVRVMSSQSVLVTWTDPLYE-KR-KVA--AN-RQYNVRYREKGESARW DYKQVSNRRALVENLVPDTMYEFAIQILEGEKEGKWSVSVYQRTPEAAPASAPENLDVWP LKGKPTSVAASWDALPESEGKVKEYILSYAPALKPFGAKSITYSGATTSAIIDGLQAGER YIFKIRAANRRGPGPQSKAFSVAIPA-----------A-AQEDSVAQQKTNIQDNSEAKK TGNAG--------------------------------------------LSPPQSSSV-S SKAQLSPSSKQLS-VHSPAVS--------------------------------------- ---------------DKKNLLSEYKNKILTR-GVLSKSQLHSRRTGEL-EPDLQS----T EVTD---------DSDSSQEATASPPK-------------AQD----------------- -----------QRRNVKPLSPSRPVHPVLASGRTSVRTHTSEMSSQTSTEK-REPP---- --------------------------------------------ALLP-----------S SAQQ---------------------------------------SSTSSVPRYTDN----- --------ETKQLRQSNNNV----------------------------------PS---- -------------------------------------------------------KTSSH PLPSRNNGLASNVE---------------------------------------------- ------------------------------------------EKPDPML----------- ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------VKVSSKTSEPGHQALPSNRQ SAVSHEGVLGHRSRS--------------------------------------------- -------------------GSLGHSRQAASKSADSHAHDTHNEFDTEEAEDRARQPSSRS Q----------QTRLSSGSSSHAWKDSKSAAVS--------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------VSSRSAV------PGYTSPHSRSSTNAKSKGKDVDK NYREDSQDEN-PLF-----------P-S------------L-----------------PS S------------------RQSSS-AIYSKRRNLQVDSSSHPRDTHGEKS---------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------P---HSDS-EEQQSQTAAPE----------KHSLLQSSLSKYKPEEQG NREVKETLARSKPREFLPRKTLSSHL-------------------------P-------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------VEKTSHSEPPQ-RAQT----------------- ------------------------------------------------------------ ---------------------------------------------------SPS------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------ILHSR-------------------- ---------------GR-----------------------------------RLPS---- ---------------------------H-------------------------------I SS---------------------------------------------------------- --------------------QSNEEL---QED---------------------------- ------------------------------------------------------------ ------------------------------------------------------------ DD---------------------------------------------------------- ----------ED------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------------GTEGSDRASR RSVFLKEVSSSGGLSASFSQGSSSSSQSKQQHP--------------------------- ------GSQV-------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ----------------------HSNKPKHTVPDSS------------------------- ------------------------------------------------------------ ----------------------------SASDTAKGNH---------------------- -----------------------------------------------------------Y NQRLSPT-----------LRQARPS----------------------------------- ------------------------------------------------------------ ----L-----------P-------------------------------------AR---- ------------------------------------------------SGAA-------- -------------------------------------------------------TRTAS Q-TEKKYGLLPSKL--SNTELPQKVPSPSSS----------------------------- ----------KSHQSVSNEEDDY---YSEYDQKEIEE---------------KPTS-LAA KR-SPSV-SRGSKNVYE------------------------------DTANNKRKSMDTL L-------------------------------------------------------LHKV ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------------S S----------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------EEEEMG------- ------------------------------------------------------------ ---------------------------------------KPSIL---------------- ----------------------------------------------------------KL SSPES------------------------------------------------------- ------------------------------------------------------------ ---------------------------P-------------------------------- ------------------------------------------------------------ ------------------------------R------------------NS--------- -----------------------------------------------DVAS--------- -QITQ------------S-SNK-HTPPKPNFV--------WPRS---------------- ---SASTT-------THTISPAV------------------------------------- -----SS----------------------------------------------------- -------------------------------TS----------SPRQRLLN--------- ----S----------RLGNPS-----QRQ-------------FV---------------- ------------------------------------------------------------ ---------------------------RPPY------R------S--------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------GYNGRPNLTTK-------- NGNGK---VIPGNNGKPSGQKVINGPQGAKWIVDLDRGLVLNAEGKYLQDSQGNPLRVKL GGDGRTIVDEKGAPVVSPDGLPLFGHSRFNKPVASAQDKPIISLGGKPLIGLE--MIKKT TTPS-TT---------------------TTTIP--------T--TTT---------T--- --------TT-----------TTT------------------------------------ --------------------------------TTTTV-------------ATTTTT--TT ----------TTPEP-------------TTTD------------------------PPTE KPAPTCPPGTYGQYDDEGNLLL-GFDGLPECN--------------------------A- ------------------------E-DTFSGLDSDV-------TATP--EAYVIYDD--- ---------------------D--------YEFFE-STL-------P-----PT-TT--- -------TTTVT-------------------------------------------TTT-- AP------TTTELEAVYPETSV----------------------V--------------- -----GTGPVSEYDIAGKKRFT--------------------------APYVTYLNKDPA APCSLTEALEHFQVESLDEIIPND--FREKDQRPLKAPHNITVVAVEGCHSFVIVDWAKP AQGDMVTGYLVYSASYDDFLKNKWSTRTAGSTHLPIENLKPNT----------------- -------------RYYFKVQAKNPFGYGPVSSSVSFITESDNPLLIVRPPG--------- ------GEPIWIPFTFKYDPTYSDCTGKQYVKRTWYRKFVGVVLCNSLRYKIYLSDDL-K -DTFYSIGDSWGRGEDHCQFVDSHLDGRTGPQSYIEALPTIRGYYRQYRQEPVSFGRIGY TTPYYYVGWYECGVPIPGKW---------------------------------------- ------------------------------------------------------ >ENSLSDP00000021447 ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------CT------------------ ----------------------------------ADSDDFLV------------------ -------------------------------------------------KF--------- ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------N---------------Y-------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------HGVCVCVC---LFCE--------- ------------------------------------------------------------ ------------------------------------------------------------ ------EKGMPSRPLRVRAQSP-------------------------------------- -----------------DGKLPFRWKPPYG-AGFRG-------PHSRSQGYPRAYG---- -ESNRRMSY------------AQMPQERQNQEARKL---ASESV---------------- ---------HVVSLPSRS-----------------SQGRSQPVYRSSLTKRKVTEE---- ---EEVEMAQDITVRVMSSQSVLVTWTDPLYE-KR-KAA--AN-RQYNVRYREKGESARW DYKQVSNRRALVENLLPDTMYEFAIQILEGEKEGKWSVSVYQRTPEAAPASAPENLDVWP LKGKPTSVAASWDALPESEGKVKEYILSYAPALKPFGAKSITYSGATTSAIIDGLQAGER YIFKIRAANRRGPGPQSKAFSVAIPA---------------------------DNSEAKK TGNAG--------------------------------------------SSSSQSSSV-S SKAQLSTSSKQLS-VHSPSVS--------------------------------------- ---------------DKKSLLSEYKNKILTR-GVLSKSQLPSRKTGEL-EPDLQS----T EVTD-----------DSSQEATTSPPK-------------AQD----------------- -----------QRRNVKLLSPSRPIHPVLASGRMSVRTHTSEVSSQMSTEK-REPP---- --------------------------------------------ALLP-----------S SAQH---------------------------------------PSASSIPRYTDN----- --------ETKQLRQSNTNV----------------------------------PS---- -------------------------------------------------------KTFSH PLPAKRNGLVSNVE---------------------------------------------- ------------------------------------------GKPDPK------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------SSKASEPGHQALPSNRQ SALSHEGVLGHRSRS--------------------------------------------- -------------------GSLGHSHQPASKSADSHTHNSHNEYDSEEAEDRGGQPSSRS Q----------QTRLSSGSSSHTWKDSKSAAAA--------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------VSSRSAA------PGYTSPHSRSSTSAKSKGKDVDK NYKEDSQDEN-PLF-----------P-T------------L-----------------PS S------------------RQSSS-AIYSKRRNPQIGSDSRSRKTHGEKS---------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------P---HSDS-EE-QSQKAAPE----------KHSLMQSSLSKSKPEEQG NREVKETLDRSKPSESLPRKTLSSHL-------------------------P-------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------AEKASHSEPPQ-RAQT----------------- ------------------------------------------------------------ ---------------------------------------------------SPS------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------ILHSR-------------------- ---------------GR-----------------------------------RLPS---- ---------------------------HRA-----------------------------V SS---------------------------------------------------------- --------------------QSNEEL---QED---------------------------- ------------------------------------------------------------ ------------------------------------------------------------ DN---------------------------------------------------------- ----------ED------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------------EREGSDRASR HSVFLKEVSSSRGLSPSFSQGSSSSSQSKQQQT--------------------------- ------GSQV-------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ----------------------PSYKPKHTQPNSS------------------------- ------------------------------------------------------------ ----------------------------SASDIAKDNQ---------------------- -----------------------------------------------------------Y TQRLSPT-----------SRQTRPS----------------------------------- ------------------------------------------------------------ ----S-----------P-------------------------------------TR---- ------------------------------------------------SGAA-------- -------------------------------------------------------TRTVS Q-TEKKKGLLPSKM--SNTEHPQKVPSPSSS----------------------------- ----------KSHQSVSNEEDDY---YSEYDQKEMEE---------------RPTS-LAA KR-SPSV-SRGNKNIYE------------------------------DTASNKRKSMDTL L-------------------------------------------------------PHKV ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------------S S----------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------EEEAME------- ------------------------------------------------------------ ---------------------------------------RPSIL---------------- ----------------------------------------------------------KM SSSES------------------------------------------------------- ------------------------------------------------------------ ---------------------------P-------------------------------- ------------------------------------------------------------ ------------------------------R------------------SS--------- -----------------------------------------------AIAS--------- -QITQ------------S-SNK-HTPSKPSFV--------WPHS---------------- ---SASTT-------THTISPAV------------------------------------- -----SS----------------------------------------------------- -------------------------------TS----------SPRQRLLN--------- ----S----------RLGSPS-----QRQ-------------FV---------------- ------------------------------------------------------------ ---------------------------RPPY------R------P--------------- ------------------------------------------------------------ -----------------GI----------------------------------------- -LCC-------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------VF-------------F----------------PVSGYNGRPNLTTK------NG NGNGK---VIPGNNGKPSGQKVINGPQGAKWIVDLDRGLVLNAEGKYLQDSQGNPLRVKL GGDGRTIVDEKGAPMVSPDGLPLFGHSRFSKPVASAQDKPIISLGGKPLIGLE--MIKRT TTPS-TT---------------------TTTTP--------T--TTT---------T--- --------TT-----------TTT------------------------------------ --------------------------------TTT-V-------------A--TTT--TT ----------TTPEP-------------PTTE------------------------PPTE KPAPTCPPGTYGQYDDEGNLLL-GFNGLPECN---------------------------- ------------------------------------------------------------ ----------------------MEGNFLLYYEFFE-STF-------L-----P---T--- -------TTTVT-------------------------------------------TTT-- AS------TTTEVEVVYPETGV----------------------G--------------- -----GTGPVSEYDIAGKKRFT--------------------------APYVTYLNKDPA APCSLTEALEHFQVESLDEIIPND--FREKDQRPLKAPQNITVVAVEGCHSFVIVDWAKP AQGDMVTGYLVYSASYDDFLKNKWSTRTAGSTHLPIENLKPNT----------------- -------------RYYFKVQAKNPFGYGPVSSSVSFITESDNPLLIVRPPG--------- ------GEPIWIPFSFKYDPTYSDCTGKQYVKRTWYRKFVGVVLCNSLRYKIYLSDDL-K -DTFYSIGDSWGRGEDHCQFVDSHLDGRTGPQSYIEALPTIRGYYRQYRQEPVSFGRIGY TTPYYYVGWYECGVPIPGKW---------------------------------------- ------------------------------------------------------ >ENSTGUP00000011724 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------EKGMPSRPLRVRAQSP-------------------------------------- -----------------DGKLPFRWKPPYG-AGFRG-------PHSRSQGYPRAYG---- -ESNRRMSY------------AQMPQERQNQEARKL---ASESV---------------- ---------HVVSLPSRS-----------------SQGRSQPVYRSSLTKRKVTEE---- ---EEVEVAQDITVRVMSSQSVLVTWTDPLYE-KR-KAA--AN-RQYNVRYREKGESARW DYKQVSNRRALVENLVPDTMYEFAIQILEGEKEGKWSVSVYQRTPEAAPASAPENLDVWP LKGKPTSVAASWDALPESEGKVKEYILSYAPALKPFGAKSITYSGATTSAIIDGLQAGER YIFKIRAANRRGSGPQSKAFSVAIPA-----------A-AHEDSVAQQKTNIQDNSEAKK TGNDG--------------------------------------------SSSSQSSSV-S SKAQLSPSSKQLS-VHSPSVS--------------------------------------- ---------------DKKSLLSEYKNKILTR-GVLSKSQLPSRKTGNL-EPDLQS----T EVTD-----------DSSQEATTSPPK-------------AQD----------------- -----------QRRNVKPLSPSRPIHPVLASGRMSVRTHTSEVLSQMSTEK-REPP---- --------------------------------------------ALLP-----------S SAQH---------------------------------------PSASSVPRYTDN----- --------ETKQLRQSSTNV----------------------------------PS---- -------------------------------------------------------KTFSH PLPAKRNGLVSNVE---------------------------------------------- ------------------------------------------GKPDPK------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------PSKTSEPGHQALPSNRQ SALSHE------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------VAQSKPSESLPRKTLSSRL-------------------------P-------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------AEKASHSEPPQ-RAQT----------------- ------------------------------------------------------------ ---------------------------------------------------SPS------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------ILHSR-------------------- ---------------GR-----------------------------------RLPS---- ---------------------------HRA-----------------------------V SS---------------------------------------------------------- --------------------QSNEEL---PED---------------------------- ------------------------------------------------------------ ------------------------------------------------------------ DD---------------------------------------------------------- ----------ED------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------------KREGSDRASR HSVFLKEVSSSRGLSPSFSQGSSSSSQSKQQQT--------------------------- ------GSQV-------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ----------------------PSYKPKHTQPNSS------------------------- ------------------------------------------------------------ ----------------------------SASDIAKDNQ---------------------- -----------------------------------------------------------Y TQRLSPT-----------SRQTRPS----------------------------------- ------------------------------------------------------------ ----L-----------P-------------------------------------TR---- ------------------------------------------------SGAA-------- -------------------------------------------------------TRTVS Q-TEKKKGLLPSKM--SNTEHPQKVPSPSSS----------------------------- ----------KSHQSVSNEDDDY---FSEYDQKEMEE---------------KPTS-LAA KR-SPSV-SRGNKNIYE------------------------------DTASNKRKSMDTL L-------------------------------------------------------PHKV ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------------S S----------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------EEEVME------- ------------------------------------------------------------ ---------------------------------------NPSIL---------------- ----------------------------------------------------------KM SSSES------------------------------------------------------- ------------------------------------------------------------ ---------------------------P-------------------------------- ------------------------------------------------------------ ------------------------------R------------------SS--------- -----------------------------------------------AIAS--------- -QITQ------------S-SNK-HTPSKPSFV--------WPRS---------------- ---SASTT-------THTIPPEV------------------------------------- -----SS----------------------------------------------------- -------------------------------TS----------SPRQRLLN--------- ----S----------RLGSPS-----QRQ-------------FV---------------- ------------------------------------------------------------ ---------------------------RPPY------R------P--------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------GYNGRPNLTTK------NG NGNGK---VIPGNNGKPSGQKVINGPQGAKWIVDLDRGLVLNAEGKYLQDSQGNPLRVKL GGDGRTIVDEKGAPMVSPDGLPLFGHSRFSKPVASAQDKPIISLGGKPLIGLE--MIKRT TTPS-TS---------------------TTTTP--------T--TTT---------T--- --------TT-----------TTT------------------------------------ --------------------------------TTT-V-------------ATTTTT--TT ----------TTPEP-------------PTSE------------------------PPTE KPAPTCPPGTYGQYDDEGNLLL-GFNGLPECN--------------------------A- ------------------------EVDTFSGLDSDV-------TATP--EAYVIYDD--- ---------------------D--------YEFFE-STL-------L-----P---T--- -------TTTIT-------------------------------------------STT-- AS------TTTEVEVVYPETGV----------------------G--------------- -----GTGPVSEYDIAGKKRFT--------------------------APYVTYLNKDPA APCSLTEALEHFQVESLDEIIPND--FREKDQRPLKAPQNITVVAVEGCHSFVIVDWAKP AQGDMVTGYLVYSASYDDFLKNKWSTRTAGSTHLPIENLKPNT----------------- -------------RYYFKVQAKNPFGYGPVSSSVSFITESDNPLLIVRPPG--------- ------GEPIWIPFTFKYDPTYSDCTGKQYVKRTWYRKFVGVVLCNSLRYKIYLSDDL-K -DTFYSIGDSWGRGEDHCQFVDSHLDGRTGPQSYIEALPTIRGYYRQYRQEPVSFGRIGY TTPYYYVGWYECGVPIPGKW---------------------------------------- ------------------------------------------------------ >ENSSCAP00000015461 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------MPSRPLRMRAQSP-------------------------------------- -----------------DSRLPFRWKPPYG-AGFRG-------PHSRSQGYPRGYG---- -ESNRRMSY------------SPMPQERQNQEARKL---ASESV---------------- ---------HVVSLPSRS-----------------SQGRSQPVYRSSLTKRKVTEE---- ---EEVEVAQDITVRVMSSQSVLVTWTDPLYE-KW-KVA--AN-RQYNVRYREKGESARW DYKQVSNRRALVENLVPDTMYEFAIQILEGEKEGKWSVSVYQRTPEAAPASAPENLDVWP LKGKPTSVAASWDALPESEGKVKEYILSYAPALKPFGAKSITYSGATTSAIIDGLQAGER YIFKIRAANRRGPGPQSKAFSVAIPA-----------A-AHEDSVAQQKTNTQDNSEAKK TGNAG--------------------------------------------SSPSQSSSV-S SKSQLSPSSKQLS-----SIS--------------------------------------- ---------------DKKSLLSEYKNKILTR-GVPSKSQLPSRKTGEL-EPDLQS----T EVTD---------DRDSSQEATTSPPK-------------AQD----------------- -----------QRRNVKPFSPSRPIHPVLALGRMSVPTHTSEVSSQMSTEE-REPP---- --------------------------------------------ALLP-----------S SAQH---------------------------------------SSASSVPRYTDN----- --------ETKQLRQSNNNV----------------------------------PS---- -------------------------------------------------------KTSSH PLPAKSNGLVSNVE---------------------------------------------- ------------------------------------------GKPDPML----------- ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------VKVSSKASELGRQALPSSRH SAVSHEGVSGHRSRS--------------------------------------------- -------------------GSLGRSHQPASKSADSHTHNSHNEFDSEEAEDRAGQPSSRS Q----------QTRLSSGSSSRTWKDSKSAAAA--------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------VSSRLAV------PGYTSPHSRSSTSAKSKGKDVDK NYREDSQDEN-PLF-----------P-S------------L-----------------PS S------------------RQSSS-TIFSKRRNPQVGPDSRSKETHGEKS---------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------P---HSDS-EEQQSQTAAPE----------KQTHLQSSLSKSKPEEQG NRGVKETLARSKPSEFLPRKTLSSRL-------------------------P-------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------VEKISHSEPPQ-RAQT----------------- ------------------------------------------------------------ ---------------------------------------------------SPS------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------ILHSR-------------------- ---------------GR-----------------------------------RLPS---- ---------------------------HRA-----------------------------V SS---------------------------------------------------------- --------------------QSNEEL---QEE---------------------------- ------------------------------------------------------------ ------------------------------------------------------------ DD---------------------------------------------------------- ----------ED------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------------ETESSDRASR HSVFPKEVSSSRGLSASFSQGSSSSSQSKQQQP--------------------------- ------GSQV-------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ----------------------PSYKPKHAQPDSS------------------------- ------------------------------------------------------------ ----------------------------SASDTAKDNQ---------------------- -----------------------------------------------------------Y NQRLSHT-----------SRQTRPS----------------------------------- ------------------------------------------------------------ ----L-----------P-------------------------------------TR---- ------------------------------------------------SGVA-------- -------------------------------------------------------SRTAS Q-TERKKGLLHSKM--ANTELPQKVPSPSSS----------------------------- ----------KSHQSVSNEEDDY---YSEYDQKEMEE---------------KPTS-LAA KR-SPSV-SRGNKNVYE------------------------------DTASNKRKSMDTL L-------------------------------------------------------PHKV ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------------S S----------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------EEEEME------- ------------------------------------------------------------ ---------------------------------------KPSIL---------------- ----------------------------------------------------------KM SSPEL------------------------------------------------------- ------------------------------------------------------------ ---------------------------P-------------------------------- ------------------------------------------------------------ ------------------------------R------------------SS--------- -----------------------------------------------ATAS--------- -QITQ------------S-SNK-HTPSKPSFV--------WPRS---------------- ---SASTT-------THTISPAV------------------------------------- -----SS----------------------------------------------------- -------------------------------TL----------SPRQRLLN--------- ----S----------RLGSPS-----QRQ-------------FV---------------- ------------------------------------------------------------ ---------------------------RPPY------R------P--------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------GYNGRPNLTMK------NG NGNGK---VIPG-NGKASGQKVINGPQGAKWIVDLDRGLVLNAEGKYLQDSQGNPLRVKL GGDGRTIVDEKGAPMVSPDGLPLFGHSRFSKPVASAQDKPIISLGGKPLIGLE--MIKKT TTPS-TT---------------------TTTIP--------T--TTT---------T--- --------TT-----------TTT------------------------------------ --------------------------------TTTTV-------------ATTTST--TT ----------TTPEP-------------TTTE------------------------PPTE KPAPTCPPGTYGEYDDEGNLLL-GFDGLPECN--------------------------A- ------------------------E-DTFSGLESDV-------TATP--EAYVVYDD--- ---------------------D--------YEFFE-STL-------P-----P---T--- -------TTTAT-------------------------------------------TTT-- AS------TTTELEAVYPETGA----------------------G--------------- -----GTGPVSEYDIAGKKRFT--------------------------APYVTYLNKDPA APCSLTEALEHFQVESLDEIIPND--FREKEQRPLKAPQNITVVAVEGCHSFVIVDWAKP AQGDMVTGYLVYSASYDDFLKNKWSTRTAGSTHLPIENLKPNT----------------- -------------RYYFKVQAKNPFGYGPVSSSVSFITESDNPLLIVRPPG--------- ------GEPIWIPFTFKYDPTYSDCTGKQYVKRTWYRKFVGVVLCNSLRYKIYLSDDL-K -DTFYSIGDSWGRGEDHCQFVDSHLDGRTGPQSYIEALPTIRGYYRQYRQEPVSFGRIGY TTPYYYVGWYECGVPIPGKW---------------------------------------- ------------------------------------------------------ >ENSZALP00000012726 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------------MCF------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------QQTYAGCWY-HVLHSNSHGVCVCVC---LFCE--------- ------------------------------------------------------------ ------------------------------------------------------------ ------ERGMPSRPLRARAQSP-------------------------------------- -----------------DGKLPFRWRPPYG-AGFRG-------PHSRSQGYPRGYG---- -ESNRRMSY------------APMPQERQNQEARKL---ASESV---------------- ---------HVVSLPSRS-----------------SQGRSQPVYRSSLTKRKVTEE---- ---EEVEVAQDITVRVMSSQSVLVTWTDPLYE-KR-KVA--AN-RQYNVRYREKGESARW DYKQVPNRRALVENLLPDTMYEFAIQILEGEKEGKWSVSVYQRTPEAAPASAPENLDVWP LKGKPTSVAASWDALPESEGKVKEYILSYAPALKPFGAKSVTYSGATTSAIIDGLQAGER YIFKIRAANRRGPGPQSKAFSVAIPA-----------G-EHQ------------------ TGNAG--------------------------------------------SSPSQSSSV-S SKAQLSPSSEQLP-VHSPSVS--------------------------------------- ---------------DKKNLLSEYKNKILTR-GVLSKSQLPSRKTGEL-ESDLQS----T EVTD---------DHDSSQEATTLPPK-------------AQD----------------- -----------QRRNVKPLSPSRPIHPVLASGRMSVQTHTSEVSSQMSTEE-REPP---- --------------------------------------------ALLP-----------S SARH---------------------------------------SSASSVPRYTDN----- --------ETKQLRQSSNNA----------------------------------PS---- -------------------------------------------------------KTSSQ PLPAKSNGLVSNVE---------------------------------------------- ------------------------------------------GKPDPVL----------- ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------VKVSPKASDSGRQASPSSQQ SAVSHEAVSGHRSRS--------------------------------------------- -------------------GSLGRSHQPASKSADSHTHDSHNEFDSEEAEDRAEQPSSRS Q----------QTRLSSGSSSRTWKDSKSAAAA--------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------GSSRSAV------PGYTSPHSRSSTSAKSNGKDVDK NYREDSEEEN-PLF-----------P-S------------L-----------------PS S------------------RQSSS-AIYSKRINP--GPDSRSRETHGEKS---------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------P---HSNS-EEQQSHTAAPE----------KHSHLQSSLSKSKPEEQG NREVKEKLARSKPSESLPRKTLSSRL-------------------------P-------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------VEKTSHSEPPQKRAQT----------------- ------------------------------------------------------------ ---------------------------------------------------SPS------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------ILHSR-------------------- ---------------GR-----------------------------------RLPS---- ---------------------------HHA-----------------------------V SS---------------------------------------------------------- --------------------QSNEEL---QEE---------------------------- ------------------------------------------------------------ ------------------------------------------------------------ DD---------------------------------------------------------- ----------ED------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------------ETEGSDRASR HSVFLKEVSSSRGLSASFSQGSSSSSQSKQQQT--------------------------- ------GSQV-------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ----------------------PSYKPKHTQPDSS------------------------- ------------------------------------------------------------ ----------------------------SASDAAKDSQ---------------------- -----------------------------------------------------------Y NQRLSHT-----------SRQARPS----------------------------------- ------------------------------------------------------------ ----L-----------P-------------------------------------AR---- ------------------------------------------------SGVA-------- -------------------------------------------------------TRTAS Q-TQKKKGLLPSKM--SNTELSQKVPSSSSS----------------------------- ----------KSHQSVSNEEDDY---YSEYDQKEMEE---------------KPTS-LAA KR-SPSV-SRGNKNAYE------------------------------DTASNKRKSMDTL L-------------------------------------------------------PHKL ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------------S S----------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------EEEEME------- ------------------------------------------------------------ ---------------------------------------KPSIL---------------- ----------------------------------------------------------KM SPPES------------------------------------------------------- ------------------------------------------------------------ ---------------------------P-------------------------------- ------------------------------------------------------------ ------------------------------R------------------SS--------- -----------------------------------------------ATAS--------- -QTTQ------------S-SNK-HTPSKPSFV--------WPRS---------------- ---SASTT-------THTISPAV------------------------------------- -----SS----------------------------------------------------- -------------------------------TS----------SPRQRLLN--------- ----S----------RLGSPS-----QRQ-------------FV---------------- ------------------------------------------------------------ ---------------------------RPPY------R------P--------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------GYNGRPNLTMKNRNGNGNG NGNGK---VIPGNNGKPSGQKVINGPQGAKWIVDLDRGLVLNAEGKYLQDSQGNPLRVKL GGDGRTIVDEKGAPMVSPDGLPLFGHSRFSKPVASAQDKPIISLGGKPLIGLE--MIKKT TTPS-TT---------------------TTTIP--------T--TTT---------T--- --------TT-----------TTT------------------------------------ --------------------------------TTT-V-------------ATTTTS--TT ----------TTPEP-------------TTTE------------------------PPTE KPAPTCPPGTYGEYDDEGNLLL-GLDGLPECN--------------------------AE GNFLFMLTPSSCIF---------SE----------------------------------- ---------------------D--------YEFFE-STL-------P-----P---T--- -------TTTAT-------------------------------------------TTT-- AS------TTTELEVVYPETGV----------------------G--------------- -----GTGPVSEYDIAGKKRFT--------------------------APYVTYLNKDPA APCSLTEALEHFQVESLDEIIPND--FREKDQRPLKAPHNITVVAVEGCHSFVIVDWAKP AQGDMVTGYLVYSASYDDFLKNKWSTRTAGSTHLPIENLKPNT----------------- -------------RYYFKVQAKNPFGYGPVSSSVSFITESDNPLLIVRPPG--------- ------GEPIWIPFTFKYDPTYSDCTGKQYVKRTWYRKFVGVVLCNSLRYKIYLSDDL-K -DTFYSIGDSWGRGEDHCQFVDSHLDGRTGPQSYVEALPTIRGYYRQYRQEPVSFGRIGY TTPYYYVGWYECGVPIPGKW---------------------------------------- ------------------------------------------------------ >ENSFALP00000012664 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------EKDMPRRPLRVRAQSP-------------------------------------- -----------------DGKLPFRWKPPYG-AGFRG-------PHSRSQGYPRGYG---- -ENNRRMSY------------APLPQERQNQEARKLACTASESV---------------- ---------HVVSMPSRS-----------------SQGRSQPVYRSSLTKRKVTEE---- ---EEVEVAQDITVRVMSSQSVLVTWTDPLYE-RR-KVA--ASGRQYNVRYREKGESARW DYKQVSNRRALVESLVPDTMYEFAIQILEGEKEGKWSVSVYQRTPEAAPASAPENLDVWP LKGKPTSVAASWDALPESEGKVKEYILSYAPALKPFGAKSITYSGATTSAIIDGLQAGER YIFKIRAANRRGPGPQSKAFSVAIPA-----------A-AHEDSVAQQKTNIQDNSEAKK TGNAG--------------------------------------------SSPSQTSSV-S SKAQLSPSSKQLS-VHSPSVS--------------------------------------- ---------------DKKSLLSEYKNKILTR-GALSKSQLPSRKAGEL-EPDLQS----T EVTD---------DHDSSQEATASPPK-------------AQD----------------- -----------QRRNVKPLSPSRPVHPVLASGRMSVRTHVSEVS---STEA-REPP---- --------------------------------------------ALLP-----------S SAQH---------------------------------------SSASSVPKYTDN----- --------ETKQLRQSSNSV----------------------------------PS---- -------------------------------------------------------KTSSH PLPAKNNGVVSSVE---------------------------------------------- ------------------------------------------GKPDPVLVKVSSKTSKPG HPALPSNRS--------------------------------------------------- ----------------PP------------------------------------------ ----------------------------S---------MLVKVSSKTSEPGHQALPSNRQ SAVSHEGVLDHRSRS--------------------------------------------- -------------------GSLG--HQPASKSADSHAHDSHNGFDSEEAEDRAGQPSSRS Q----------QTRLSSGSSSRPWKDSKSAVAA--------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------VSSRSAV------PGYTSPHSRSSTTAKSKGKDVDK NYREVSQDVN-PLF-----------P-S------------L-----------------PS S------------------RQSSS-AINSKRRNPQVDSDSRPRETQGEKS---------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------P---HSDS-EEKRSQTAAPE----------KHSLLQSSLSKYKPEEQG NQEVKETLARSKPTESFPRKTSSSRL-------------------------P-------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------VEKTSHSEPPQ-RAQT----------------- ------------------------------------------------------------ ---------------------------------------------------SPS------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------ILHSR-------------------- ---------------GR-----------------------------------RLPS---- ---------------------------H-------------------------------I SS---------------------------------------------------------- --------------------Q--------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------KVSSSRGLSASFSQGSSSPSQSKQQQP--------------------------- ------GSQV-------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ----------------------PSYKPKHTQPDSS------------------------- ------------------------------------------------------------ ----------------------------SASDAAKDNQ---------------------- -----------------------------------------------------------Y NQRLSPT-----------LRQARPS----------------------------------- ------------------------------------------------------------ ----L-----------P-------------------------------------TR---- ------------------------------------------------SGVA-------- -------------------------------------------------------TRTAS Q-TEKKYGLLPSKM--SNTELPQKVPSPSSS----------------------------- ----------KSHQSVSNEEDDY---YSEYDQKEMEE---------------KPTS-LAA KR-SPSV-SRGNNNVYE------------------------------DTASSKRKSMDTL L-------------------------------------------------------PHKV ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------------S S----------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------EEEEME------- ------------------------------------------------------------ ---------------------------------------KPSIL---------------- ----------------------------------------------------------KV S-SES------------------------------------------------------- ------------------------------------------------------------ ---------------------------P-------------------------------- ------------------------------------------------------------ ------------------------------R------------------SS--------- -----------------------------------------------SVAS--------- -RITQ------------S-SNK-RTPSKPSFV--------WPRS---------------- ---SASTT-------THTISPAV------------------------------------- -----SS----------------------------------------------------- -------------------------------TS----------SPRQRLLN--------- ----S----------RLGSPS-----QRQ-------------FV---------------- ------------------------------------------------------------ ---------------------------RPPY------R------A--------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------GYNGRPNLTTK------NG NGNGK---VIPGNNGKPSGQKVINGPQGAKWIVDLDRGLVLNAEGKYLQDSQGKPLRVKL GGDGRTIVDEKGAPMVSPDGLPLFGHSRFSKPVASAQDKPIISLGGKPLIGLE--MIKKT TTPS-TT---------------------TTTVP--------T--TTT---------T--- --------TT-----------TTT------------------------------------ --------------------------------TTTTV-------------A--TTT--TS ----------TTPEP-------------TTTD------------------------PPTE KPAPTCPPGTYGQYDDEGNLLL-GFDGLPDCN--------------------------A- ------------------------EVDTFSGLDSDV-------TATP--EAYVIYDD--- ---------------------D--------YEFFE-STL-------P-----PTTTT--- -------TTTVT-------------------------------------------TTT-- AS------TTTELEAVYPETSV----------------------G--------------- -----GTGPVSEYDIAGKKRFT--------------------------APYVTYLNKDPA APCSLTEALEHFQVESLDEIIPND--FREKDQRPLKAPHNITVVAVEGCHSFVIVDWAKP AQGDTVTGYLVYSASYDDFLKNKWSTRTAGSTHLPIENLKPNT----------------- -------------RYYFKVQAKNPFGYGPVSSSVSFITESDNPLLIVRPPG--------- ------GEPIWIPFTFKYDPTYSDCTGKQYVKRTWYRKFVGVVLCNSLRYKIYLSDDL-K -DTFYSIGDSWGRGEDHCQFVDSHLDGRTGPQSYIEALPTIRGYYRQYRQEPVSFGRIGY TTPYYYVGWYECGVPIPGKW---------------------------------------- ------------------------------------------------------ >ENSCPGP00000021255 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------------MAG------ -------------------------------PAAPR------------------------ ------------------------------------------APPRPWAALLLLAALLPA A---APEKDMPNRPLRVRAQSP-------------------------------------- -----------------DGRLSFRWKPPYG-AGFRG-------PRSRSQGYPRGYG---- -ESSRRMSY------------APLPQERQNQEARKL---ASESV---------------- ---------HVVSLPSRS-----------------SQGRSQPVYRSSLTKRKVTEE---- ---EEVEVAQDITVRVMSSQSVLVAWTDPLYE-KQ-KVA--AN-RQYSVRYREKGESARW DYKQVSNRRALVENLLPDTMYEFAVQILEGEKEGKWSVSVYQRTPEAAPATAPENLDVWP LKGKPTSVAASWDALPESEGKVKEYILSYAPALKPFGAKSITYSGATTSAIIDGLQAGER YIFKIRAANRRGPGPQSKAFSVAIPA-----------A-AHEDSVAQQQTNIQDNSEAKK TGNAG--------------------------------------------SSPSQTSSF-S SKVQPSLSPKQSS-VRTPNVS--------------------------------------- ---------------DKKSLLSEYKNKILTRGGVLSKSQLPSRKTGEL-EPDLQS----T EVTD---------DHDSSQEAPTMPPK-------------AQD----------------- -----------QRRIVRPLSPSRPVHPVLASGRTPVRTHTSEVSQQTSTEK-HEPP---- --------------------------------------------ALSP-----------S SAQR---------------------------------------SSASSVPKYTDN----- --------ETKQMRQSNTNV----------------------------------PS---- -------------------------------------------------------KTSSH PLPAKNNDLAGNVE---------------------------------------------- ------------------------------------------GKPGPTL----------- ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------VKVSSKTSEPSRLALPSNQQ SAISHDVVPSHASRS--------------------------------------------- -------------------GSLGHSHQPSSKSTDAHARESHNEFDSEEAEERAGQTSSRS Q----------QTRRPSSSSSHTWKNSKLAAVA--------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------ASSRSAV------SGHVSPHHRSSSSARSNRKDIDK NYREDSQDAN-PLF-----------P-S------------L-----------------PS S------------------RQSSS-SIYTKRRNPQVDSDSHLRETPGEKS---------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------P---HSDS-AEQQSRAAAAE----------KHSLLQSSLSKHKSEEQD SQEVKETLARSKPSVSLPKKTFPSHL-------------------------P-------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------LEKTSRSEPPQ-RPQV----------------- ------------------------------------------------------------ ---------------------------------------------------SPS------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------LLHSR-------------------- ---------------GR-----------------------------------RLPS---- ---------------------------H-------------------------------V PS---------------------------------------------------------- --------------------QSNEEL---QED---------------------------- ------------------------------------------------------------ ------------------------------------------------------------ HE---------------------------------------------------------- ----------ED------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------------ATEGSDRASR RSVFPKDVSSSRGLPASFSQGSSSSSLSKQQQP--------------------------- ------GSQV-------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ----------------------PSYKPKLTQPDSS------------------------- ------------------------------------------------------------ ----------------------------SASDTTKDNQ---------------------- -----------------------------------------------------------Y NPRLSST----------SSRQARPS----------------------------------- ------------------------------------------------------------ ----L-----------P-------------------------------------TR---- ------------------------------------------------SMVV-------- -------------------------------------------------------TRTVS Q-TEKKHGLLPSKM--SKPELPQRVPSSSSS----------------------------- ----------KSRQSVSNEEDDY---YSEYDQKEVKE---------------KPTS-LAA KW-SPSV-SRGNKNTYD------------------------------D---NKRKFMDTL L-------------------------------------------------------PHKV ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------------S S----------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------EEEEKE------- ------------------------------------------------------------ ---------------------------------------KPPTL---------------- ----------------------------------------------------------KI SSPES------------------------------------------------------- ------------------------------------------------------------ ---------------------------P-------------------------------- ------------------------------------------------------------ ------------------------------G------------------SS--------- -----------------------------------------------AIVS--------- -RITQ------------S-SNK-HTPSKPSFV--------WPRS---------------- ---SASTT-------THTVSPTI------------------------------------- ----SSS----------------------------------------------------- -------------------------------TL----------SPRHRLLN--------- ----S----------RLRNPS-----QRQ-------------VV---------------- ------------------------------------------------------------ ---------------------------RPPY------R------Q--------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------GYNGRPNLTTK--NGNGNG NGNGK---IIPGNNGKPSGQRVINGPQGTKWIVDLDRGLVLNTEGKYLQDSQGNPLRVKL GGDGRTIVDEKGAPMVSPDGLPLFGHGRFSKPVASAQDKPIISLGGKPLIGLE--MIKKT TTPS-TT---------------------TTTIP--------T--TTT---------T--- --------TT-----------TTT------------------------------------ --------------------------------TTTTV-------------A---TT--TT ----------TTPEP-------------TTTE------------------------PPTE KPPPTCPPGTYAQYDDEGNLLL-GFDGLPECN--------------------------A- ------------------------E-DTFSGLDSDV-------TATP--EAYVIYDD--- ---------------------D--------YEFFE-STL-------P-----P--TT--- -------TTTVS-------------------------------------------TTT-- AS------TTTESEIVYPETSV----------------------V--------------- -----GTGPVSEYDIAGKKRFT--------------------------APYVTYLNKDPA APCSLTEALEHFQVESLDEIIPND--LREKDLRPLKAPHNITVVAVEGCHSFVIVDWAKP ARGDMVTGYLVYSASYDDFLKNKWSTRTAGTTHLPIENLKPNT----------------- -------------RYYFKVQAKNPFGYGPVSSSVSFITESDNPLLIVRPPG--------- ------GEPIWIPFTFKYDPTYSDCSGKQYVKRTWYRKFVGVVLCNSLRYKIYLSDHL-K -DTFYSIGDSWGRGEDHCQFVDSHLDGRTGPQSYVEALPTIRGYYRQYRQEPVSFGRIGY TTPYYYVGWYECGVPIPGKW---------------------------------------- ------------------------------------------------------ >ENSCPUP00000020185 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------------ML------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------HNNSDGFCVCVC---FFFE--------- ------------------------------------------------------------ ------------------------------------------------------------ ------EKDMPNRPLRVRAQSP-------------------------------------- -----------------DGRLSFRWKPPYG-AGFRG-------PRSRSQGYPRGYG---- -ESSRRMSY------------APLPQERQNQEARKL---ASESV---------------- ---------HVVSLPSRS-----------------SQGRSQPVYRSSLTKRKVTEE---- ---EEVEVAQDITVRVMSSQSVLVAWTDPLYE-KQ-KVA--AN-RQYSVRYREKGESARW DYKQVSNRRALVENLLPDTMYEFAVQILEGEKEGKWSVSVYQRTPEAAPATAPENLDVWP LKGKPTSVAASWDALPESEGKVKEYILSYAPALKPFGAKSITYSGATTSAIIDGLQAGER YIFKIRAANRRGPGPQSKAFSVAIPA-----------A-AHEDSVAQQQTNIQDNSEAKK TGNAG--------------------------------------------SSPSQTSSF-S SKVQPSLSPKQSS-VRTPNVS--------------------------------------- ---------------DKKSLLSEYKNKILTRGGVLSKSQLPSRKTGEV-EPDLQS----T EVTD---------DHDSSQEAPTMPPK-------------AQD----------------- -----------QRRIVRPLSPSRPVHPVLALGRTPVRTHTSEVSQQTSTEK-HEPP---- --------------------------------------------GLSP-----------S SAQR---------------------------------------SSASSVPKYTDN----- --------ETKQMRQSNTNV----------------------------------PS---- -------------------------------------------------------KTSSH PPPAKNNDLAGNME---------------------------------------------- ------------------------------------------GKPGSTL----------- ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------VKVSSKTSEPSRLALPSNRQ SAISHDVVPSHPSRS--------------------------------------------- -------------------GSLGHSHQPSSTSTDAHARERHNEFDSEEEEERAGQTSSRS Q----------QTRLPSSSSSHTWKNSKLAAVA--------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------ASSRSAV------SGHVSPHLRSSSSAKSNRKDIDK NYREDSQDGN-PLF-----------P-S------------L-----------------PS S------------------RQSSS-SIYSKRRNPQVDSDSHLRETHGEKS---------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------P---HSDS-AEQQSRAAAAE----------KHSLLQSSLSKHKSEEQD SQEVKETLARSKPSVSLPKKTFPSHL-------------------------P-------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------LEKTSRSEPPQ-RAQM----------------- ------------------------------------------------------------ ---------------------------------------------------SPS------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------LLHSR-------------------- ---------------GR-----------------------------------RLPS---- ---------------------------H-------------------------------V PS---------------------------------------------------------- --------------------QSNEEL---QED---------------------------- ------------------------------------------------------------ ------------------------------------------------------------ DD---------------------------------------------------------- ----------ED------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------------ATEGSDRASR RSVFPKDVSSSRGLPASFSQGSSSSSLSKQQQP--------------------------- ------GSQV-------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ----------------------PSYKPKLTQPDSS------------------------- ------------------------------------------------------------ ----------------------------SASDTTKDNQ---------------------- -----------------------------------------------------------Y NPRLSST----------SSRQARPS----------------------------------- ------------------------------------------------------------ ----L-----------P-------------------------------------TR---- ------------------------------------------------SMVV-------- -------------------------------------------------------TRTVS Q-TEKKHGLLPSKM--SKPELPQRVPSSSSS----------------------------- ----------KSRQSVSNEEDDY---YSEYDQKEVKE---------------KPTS-LAA KW-SPSV-SRGNKNTYD------------------------------D---NKRKFMDTL L-------------------------------------------------------PHKV ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------------S S----------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------EEEEKE------- ------------------------------------------------------------ ---------------------------------------KPPTL---------------- ----------------------------------------------------------KI SSPES------------------------------------------------------- ------------------------------------------------------------ ---------------------------P-------------------------------- ------------------------------------------------------------ ------------------------------G------------------SS--------- -----------------------------------------------AIVS--------- -RITQ------------S-SNK-HTPSKPSFV--------WPRS---------------- ---SASTT-------THTVSPTI------------------------------------- ----SSS----------------------------------------------------- -------------------------------TL----------SPRQRLLN--------- ----S----------RLRSPS-----QRQ-------------VV---------------- ------------------------------------------------------------ ---------------------------RPPY------R------Q--------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------GYNGRPNLTTK------NG NGNGK---IIPGNNGKPSGQRVINGPQGTKWIVDLDRGLVLNTEGKYLQDSQGNPLRVKL GGDGRTIVDEKGAPMVSPDGLPLFGHGRFSKPVASAQDKPIISLGGKPLIGLE--MIKKT TTPS-TT---------------------TTTIP--------T--TTT---------T--- --------TT-----------TTT------------------------------------ --------------------------------TTTTV-------------A---TT--TT ----------TTPEP-------------TTTE------------------------PPTE KPPPTCPPGTYAQYDDEGNLLL-GFDGLPECN--------------------------A- ------------------------E-DTFSGLDSDV-------TATP--EAYVIYDD--- ---------------------D--------YEFFE-STL-------P-----P--TT--- -------TTTVS-------------------------------------------TTT-- AS------TTTESEIVYPETSV----------------------V--------------- -----GTGPVSEYDIAGKKRFT--------------------------APYVTYLNKDPA APCSLTEALEHFQVESLDEIIPND--LREKDLRPLKAPHNITVVAVEGCHSFVIVDWAKP ARGDMVTGYLVYSASYDDFLKNKWSTRTAGTTHLPIENLKPNT----------------- -------------RYYFKVQAKNPFGYGPVSSSVSFITESDNPLLIVRPPG--------- ------GEPIWIPFTFKYDPTYSDCSGKQYVKRTWYRKFVGVVLCNSLRYKIYLSDDL-K -DTFYSIGDSWGRGEDHCQFVDSHLDGRTGPQSYVEALPTIRGYYRQYRQEPVSFGRIGY TTPYYYVGWYECGVPIPGKW---------------------------------------- ------------------------------------------------------ >ENSMUNP00000013213 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------------M-------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------RAQSP-------------------------------------- -----------------DGRLPFRWKPPYGGAGLRS-------PRSRSQGYLRGYG---- -ESSRRMNY------------APLLQERQNQEARKL---ASESV---------------- ---------HVVSLPSRS-----------------SQGRSQPVYRSSLTKRKVTEE---- ---EEVEVAQDITVRVMSSQSVLVVWTDPLYE-KQ-KVA--AN-RQYNVRYREKGESARW DYKQVSNRRALVENLLPDTMYEFAVQILEGEKEGKWSVSVYQRTPEAAPSSAPENLDVWP LKGKPTSVAASWDALPESEGKVKEYILSYAPALKPFGAKSITYSGATTSAIIDGLQAGER YIFKIRAANRRGPGPQSKAFSVAIPA-----------A-VHEDSVAKQQTNIPDNSEAKK NRNAG--------------------------------------------SSPSQTSSV-S SKVQPSLSSKQSS-VHSPNVS--------------------------------------- ---------------DKKSLLSEYKNKILTR-GVLSKSQLPSRKTEEL-ETDLQS----T EVTD---------DQDSSQEASMTPPK-------------AQD----------------- -----------QRRYVRPLSPSRPIHPVLASG---VQTHTSEVSRQTSTDK-HEPP---- --------------------------------------------PLLP-----------S SAQ----------------------------------------SSALSVPKHTDN----- --------ETKQLRQSNTNV----------------------------------PS---- -------------------------------------------------------KASSH LRPAKNNDLTGNVE---------------------------------------------- ------------------------------------------GRPDPML----------- ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------VKVSSETSEPTRTALPSNRQ SAISREVVPSHPRRS--------------------------------------------- -------------------GSLGHSLQPSSKSAGSHARDSHNEFDSEEAADRAVRPSSRS Q----------QTKLPSGSSSRTWKDSKLAAVAVQLKSAV-------------------- -----------------------SGQNSP------------------------------- ------------------------------------------------------------ ----------QS--HS-------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------------ST S------------------DKSNG-------------------------------KDVDK NYREDSQEAN-PLS-----------R-S------------L-----------------PS S------------------RQSSS-AVYSKRRNSQVSSDSHLRETHGEKS---------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------P---HSDS-EEQQSRAAAPE----------KHSPLQSSFSKHKPEEED SQEVKEILARSKPSISLPKKAFSSHL-------------------------P-------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------LEKTSHSEPSQ-RAQT----------------- ------------------------------------------------------------ ---------------------------------------------------SPS------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------LLHSR-------------------- ---------------GR-----------------------------------RLPS---- ---------------------------H-------------------------------A SS---------------------------------------------------------- --------------------QSNEEL---QED---------------------------- ------------------------------------------------------------ ------------------------------------------------------------ DD---------------------------------------------------------- ----------ED------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------------VTEVSDRASS RSVFPKEVSSSRGLPASFSQGSSSSSLSKQQQP--------------------------- ------GSQV-------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ----------------------PPYKPKLTQPHSS------------------------- ------------------------------------------------------------ ----------------------------SASDTAKDNQ---------------------- -----------------------------------------------------------Y NPRLSST----------SSKQAHSS----------------------------------- ------------------------------------------------------------ ----L-----------P-------------------------------------TR---- ------------------------------------------------SRVA-------- -------------------------------------------------------TRTVS Q-TEKKYGLLPSKM--SKAELPQKVPSSSSS----------------------------- ----------KSRQSVSNEEDDY---YNEYDQKEVEE---------------KPTS-LAA KF-PPSI-SRGNKNMYE------------------------------DIASNQRKSMDTL L-------------------------------------------------------PHKV ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------------S S----------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------EEEEKE------- ------------------------------------------------------------ ---------------------------------------KTPTL---------------- ----------------------------------------------------------KM SSPES------------------------------------------------------- ------------------------------------------------------------ ---------------------------P-------------------------------- ------------------------------------------------------------ ------------------------------G------------------SS--------- -----------------------------------------------PIAS--------- -RIAQ------------S-SNK-HTPPKPSFV--------WPRS---------------- ---SASTT-------THTVSPTV------------------------------------- -----SS----------------------------------------------------- -------------------------------TL----------SPRQRLLN--------- ----S----------RLWNPS-----QRQ-------------FV---------------- ------------------------------------------------------------ ---------------------------RPPY------R------Q--------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------GYNGRPNLTTK-------- NGNGK---IIPGNNGKPSGQRVINGPQGTKWIVDLDRGLVLNVEGKYLQDSQGNPLRVKL GGDGRTIVDEKGAPVVSPDGLPLFGHSRFNKPVASAQDKPIISLGGKPLIGLE--MIKKT TTPS-TT---------------------TTTIP--------P--TTT---------T--- --------TT-----------TTT------------------------------------ --------------------------------TTTTV-------------A---TT--TT ----------TTPEP-------------TTTE------------------------PPTQ KPLPTCPPGTYGQYDDEGNLLL-GFDGLPECD--------------------------A- ------------------------E-ETFSGLDSDV-------TATP--EAYVIYDD--- ---------------------D--------YEFFE-STL-------P-----P---T--- -------TTTAT-------------------------------------------TTT-- AS------TATELEVVYPETSV----------------------V--------------- -----GTSPVSEYDIAGKKRFT--------------------------APYVTYLNKDPA APCSLTEALEHFQVESLDEIIPND--LREKDLRPLKAPHNITVVAVEGCHSFVIVDWAKP ARGDMVTGYLVYSASYDDFLKNKWSTRTAGSTHLPIENLKPNT----------------- -------------RYYFKVQAKNPFGYGPISSSVSFITESDNPLLIVRPPG--------- ------GEPIWIPFTFKYDPTYSDCSGKQYVKRTWYRKFVGVVLCNSLRYKIYLSDDL-K -DTFYSIGDSWGRGEDHCQFVDSHLDGRTGPQSYVEALPTIRGYYRQYRQEPVSFGRIGH TTPYYYVGWYECGVPIPGKW---------------------------------------- ------------------------------------------------------ >ENSABRP00000020331 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------------M-------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------PNRPLRVRAQSP-------------------------------------- -----------------DGRFSFRWKPPYG-AGFRG-------PRSRSQGHLRGYG---- -ESGRRMSY------------APLLQERQNQEARKL---ASESV---------------- ---------HVVSLPSRN-----------------TQGRSQPVYRSSLTKRKVTEE---- ---EEVEVVQDITVRVMSSQSVLVAWTDPLYE-KQ-KVA--AN-RQYSVRYREKGESARW DYKQVSNRRALVENLAPDTMYEFAVQILDGEKEGKWSVSVYQRTPEAAPASAPENLDVWP LKGKPTSVAASWDALPESEGKVKEYILSYAPALKPFGAKSITYSGATTSAIIDGLQAGER YIFKIRAANRRGPGPQSKAFSVAIPA-----------A-PNEDSVAHQQKNIQDNSEAKK PVNTG--------------------------------------------SSPSQTSSV-S SKVQTSLSSKQSS-VRSPGVS--------------------------------------- ---------------DKKSLLSEYKNKILSRGGVLSKSQLPSRKTEEL-ESDLQS----T EVTD---------DHNSSEEAATMPPK-------------AED----------------- -----------QRRVVRPVSPSRMVHPVLTAGRTPVRTHTSDVSRQANTEK-HEPS---- --------------------------------------------ALLP-----------S SAQR---------------------------------------SSASSVPKYTDN----- --------ETKQLRQSNANV----------------------------------PSPK-- -------------------------------------------------ASSLSL----- --PTKNNDLAGNVE---------------------------------------------- ------------------------------------------EKPDSVL----------- ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------VKVPSKTSEPSRLALPPNRQ SAVSHEVVPSHPSRS--------------------------------------------- -------------------GSVGHSHQPSSKSTDSRARDNQNEFDSEEAEGRAGQPSSRS Q----------QTRLPSGSSSRTWKDSKLAAVA--------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------VSSRSAV------SGHSSPHSHSSTSAKSNGKDVDK SYREDSQDEK-PLLPD-----VAHNP-S------------L-----------------PS S------------------RQSSS-AIYSKRRNPHVDPDSHLRETHSEKS---------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------P---HSDSGEEQQRRVAAPE----------KHS-LQPPLSKHKLEEQE SQEVKETLAQSKPSVSLPKKTFPSHL-------------------------P-------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------SQKTSRSEPLQ-KAQT----------------- ------------------------------------------------------------ ---------------------------------------------------SPS------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------LLHSR-------------------- ---------------GR-----------------------------------RLPS---- ---------------------------P-------------------------------V LS---------------------------------------------------------- --------------------KSNEEL---QED---------------------------- ------------------------------------------------------------ ------------------------------------------------------------ DD---------------------------------------------------------- ----------ED------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------------VTEGSDRASS HSVFPKEVSSSRGLPASFSQGSSSSSPSKQQQP--------------------------- ------RSQV-------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ----------------------PSYNSKLTQPDSS------------------------- ------------------------------------------------------------ ----------------------------SASDTAKENQ---------------------- -----------------------------------------------------------Y NLKLPST----------SSRQTRPS----------------------------------- ------------------------------------------------------------ ----L-----------P-------------------------------------TR---- ------------------------------------------------SRAD-------- -------------------------------------------------------TRTVS Q-TEKKYGLLPSKM--SKTELPQKVP-SSSS----------------------------- ----------KSRQSVSNEEDDY---YSEYDEKEGEE---------------KPTS-LAA KW-SPSV-SRGNKNTYD------------------------------DTTSNTRKSMDTL L-------------------------------------------------------PHKL ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------------R S----------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------EEEEKE------- ------------------------------------------------------------ ---------------------------------------ETPTL---------------- ----------------------------------------------------------KM SSPES------------------------------------------------------- ------------------------------------------------------------ ---------------------------P-------------------------------- ------------------------------------------------------------ ------------------------------G------------------SS--------- -----------------------------------------------AIAS--------- -RITH------------S-PNK-HTPSKPSFV--------WPRP---------------- ---SASTT-------AHTVPPTV------------------------------------- ----SSS----------------------------------------------------- -------------------------------TL----------SPRQRLLN--------- ----S----------RLRSPS-----QRQ-------------FV---------------- ------------------------------------------------------------ ---------------------------RPPY------R------Q--------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------GYNGRPNLTTK-------- NGNGK---ILPGNNGKPSGQRVINGPQGTKWIVDLDRGLVLNVEGKYLQDSQGKPLRVKL GGDGRTIVDEKGAPMVSPDGLPLFGHGRFSKPVASAQDKPIISLGGKPLIGLE--MIKKT TTPS-TT---------------------TTTIP--------T--TTT---------T--- --------TT-----------TTT------------------------------------ --------------------------------TTTTI-------------A---TT--TT ----------TTPEP-------------TTTE------------------------PPTE KPPPTCPPGTYGQYDDEGNLLI-GFDGLPECN--------------------------A- ------------------------EVDTFSGLDSDV-------TATP--EAYVIYDD--- ---------------------D--------YEFFE-STL-------P-----P---T--- -------TTTVT-------------------------------------------TTT-- AS------TTTESEIDYPETSV----------------------V--------------- -----GSGPVSEYDIAGKKRFT--------------------------APYVTYLNKDPA APCSLTEALEHFQVESLDEIIPND--LKEREPRPLKAPHNITVVAVEGCHSFVIVDWAKP ARGDMVTGYLVYSASYDDFLKNKWSTRTAGTTHLPIENLKPNT----------------- -------------RYYFKVQAKNPFGYGPVSSSVSFITESDNPLLIVRPPG--------- ------GEPIWIPFTFKYDPTYSDCSGKQYVKRTWYRKFVGVVLCNSLRYKIYLSDDL-K -DTFYSIGDSWGRGEDHCQFVDSHLDGRTGPQSYVEALPTIRGYYRQYRQEPVSFGRIGH MTPYYYVGWYECGVPIPGKW---------------------------------------- ------------------------------------------------------ >ENSNMEP00000024983 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------------MLFSTYACN RCMW-------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------AAIYVTCFIVTVVGF-------------------------------- ----------------------------------------VCVC---LFFE--------- ------------------------------------------------------------ ------------------------------------------------------------ ------EKDMPSRPLRARAQSP-------------------------------------- -----------------DGRFSFRWRPPYG-AGFRG-------PRSRSQ--IRGYG---- -ESSRRMSY------------APLPQERQNQEARKL---ASESV---------------- ---------HVVSLPSRI-----------------TQGRSQPVYRSSLTKRKVIEE---- ---EEAEMVQDITVRVMSSQSVLVAWTDPQYE-KQ-KVA--AN-RQYNVRYREKGESARW DYKQVSNRRALVENLAPDTMYEFAVQILEGEKEGKWSVSVFQRTPEAAPTSAPENLDVWP LKGKPTSVAASWDALPESEGKVKEYILSYAPALKPFGAKSITYSGATTSAIIDGLQAGER YIFKIRAANRRGPGPQSKAFSVAIPA-----------A-PNEDSVAQQQTKIRDNSEAKK PVNAG--------------------------------------------SSPSQSSSV-S SQVQMSLSSKQSS-VRSPRVG--------------------------------------- ---------------DKKSLLSEYKNKVLTQEGILSKSQLPSRKTGEL-ELDLQS----T EVTE---------DHNSSEEAPTTLPK-------------AQD----------------- -----------HRRIVRPLSSSRTIHPVLASGRTPVRTRTSEVSRQTSTEK-REPS---- --------------------------------------------VSSP-----------S SAQR---------------------------------------TSASSVPKYSDN----- --------ETKQLRQSNANV----------------------------------PSPK-- -------------------------------------------------ASSHSL----- --PAKNNDLSGSVE---------------------------------------------- ------------------------------------------EKPDPLL----------- ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------VKVPPKTSEPGLLGLPSNRE SVVTHEVDPSR------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------PSVSLPKKTFPSHL-------------------------PSQ------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------KTQKTSRSEPLQ-KVQT----------------- ------------------------------------------------------------ ---------------------------------------------------SPS------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------LLHSR-------------------- ---------------GR-----------------------------------RLPS---- ---------------------------P-------------------------------V SS---------------------------------------------------------- --------------------QSNEEL---QED---------------------------- ------------------------------------------------------------ ------------------------------------------------------------ YD---------------------------------------------------------- ----------ED------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------------VTEDSDRASS RSVFPKEVSTSRGLPTSFSQGSSSSALSKQQQP--------------------------- ------GSQV-------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ----------------------PSYKSRLTQPDTS------------------------- ------------------------------------------------------------ ----------------------------SASGKAKDNQ---------------------- -----------------------------------------------------------Y NSKLSST----------SSRQTRPS----------------------------------- ------------------------------------------------------------ ----L-----------P-------------------------------------SQ---- ------------------------------------------------SRAA-------- -------------------------------------------------------TRIVS H-TEKKYDLLPSKM--SQTELAQKVPSFSSS----------------------------- ----------KSRQSVSDEEDDY---NSEYDQKEMEE---------------KPTS-LAA KR-SPSL-SRGNKNTYD------------------------------DTTSNKKKSMDTL L-------------------------------------------------------PHKL ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------------R S----------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------EEEEKE------- ------------------------------------------------------------ ---------------------------------------GTPTL---------------- ----------------------------------------------------------KI SSPES------------------------------------------------------- ------------------------------------------------------------ ---------------------------P-------------------------------- ------------------------------------------------------------ ------------------------------G------------------SS--------- -----------------------------------------------AVAS--------- -RIIH------------S-SNK-HNPSKPSFI--------WPRS---------------- ---SQSTT-------THTVPPTV------------------------------------- ----SSS----------------------------------------------------- -------------------------------TL----------SPRQRLLN--------- ----S----------RLRSPS-----QRQ-------------FV---------------- ------------------------------------------------------------ ---------------------------RPPY------R------Q--------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------GYGGRPNLTTK-------- NGNGK---ILAGNNGKPSGQRVINGPQGTKWIVDLDRGLVLNVEGKYLQDSQGNPLRVKL GGDGRTIVDEKGAPMVSPDGIPLFGHGRFSKPVASAQDKPIISLGGKPLIGLE--MVKKT TTPS-TT---------------------TTTTP--------P--TTT---------T--- --------TT-----------TTT------------------------------------ --------------------------------TTT-------------------TT--TT ----------TTPEP-------------TTTE------------------------PPTE KPPPTCPPGTYAQYDDEGSLVL-GFDGLPECS--------------------------A- ------------------------EVDTFSGLDSEV-------TATP--EAYVIYDD--- ---------------------D--------YEFFE-STL-------L-----P---T--- -------TTTVT-------------------------------------------TT--- --------ATTESEIVYPETSV----------------------V--------------- -----GTGPVSEYDIAGKKRFT--------------------------APYVTYLNKDPA APCSLTEALEHFQVESLDEIIPND--LKEKDARPLKAPHNITVVAVEGCHSFVIVDWAKP TQGDMVTGYLVYSASYDDFLKNKWSTRTAGTTHLPIENLKPNT----------------- -------------RYYFKVQAKNPFGYGPVSSSVSFITESDNPLLIVRPPG--------- ------GEPIWIPFTFKYDPTYSDCSGKQYVKRTWYRKFVGVVLCNSLRYKIYLSDDL-K -DTFYSIGDSWGRGEDHCQFVDSHLDGRTGPQSYIEALPTIRGYYRQYRQEPVSFGRIGY TTPYYYVGWYECGVPIPGKW---------------------------------------- ------------------------------------------------------ >ENSGALP00000019042 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------------ML------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------FV-----CL------------------------ -------------------QQMYLGCYVCHMLYNNCGGVCVCVC---LFFE--------- ------------------------------------------------------------ ------------------------------------------------------------ ------EKDMPSRPLRARAQSP-------------------------------------- -----------------DGRFSFRWRPPYG-AGFRG-------PRSRSQ--IRGYG---- -ESSRRMSY------------APLPQERQNQEARKL---ASESV---------------- ---------HVVSLPSRS-----------------IQGRSQPVYRSSLTKRKVIEE---- ---EEVEVVQDITVRVMSSQSVLVAWTDPQYE-KQ-KAA--AN-RQYNVRYREKGESARW DYKQVSNRRALVENLAPDTMYEFAVQILEGEKEGKWSVSVFQRTPEAAPTSAPENLDVWP LKGKPTSVAASWDALPESEGKVKEYILSYAPALKPFGAKSITYSGATTSAIIDGLQAGER YIFKIRAANRRGPGPQSKAFSVAIPS-----------A-PNEDSVAQKQTKIQDNSEVKK PLNAG--------------------------------------------SSPSQSSSV-S SQVQMSLSSKQSS-VHSPGVG--------------------------------------- ---------------DKKSLLSEYKNKVLTRGGVPSKSQLPSRKTGEL-ELNLQS----T EVTE---------DHNSSEEAPVTLPK-------------AQD----------------- -----------HRRIARPLSSSRTIHPVLASGRTPVRTHTSEVSRQTSTEK-REPS---- --------------------------------------------AMSP-----------S SAQR---------------------------------------SSASSVPKNSDN----- --------ETKQLRQSNTNV----------------------------------PSPK-- -------------------------------------------------ASSHSL----- --PA-------NME---------------------------------------------- ------------------------------------------EKPNPLL----------- ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------VKVPSKTSEPGLLGLPSNRQ SVVTHEVDPSH------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------PSVSLPKKTFSSHL-------------------------PSQ------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------RTQKSSHSEPLQ-KVQT----------------- ------------------------------------------------------------ ---------------------------------------------------SPS------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------LLHSR-------------------- ---------------GR-----------------------------------RLPS---- ---------------------------P-------------------------------V SS---------------------------------------------------------- --------------------QSNEEL---QED---------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ND---------------------------------------------------------- ----------ED------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------------VTEDSDRASS RSVFPKELSTSRGLPTSFSQGSSSSSLSKQQQP--------------------------- ------GSQV-------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ----------------------PSYKSVLGQPDSS------------------------- ------------------------------------------------------------ ----------------------------SASGKAKDNQ---------------------- -----------------------------------------------------------Y NSKLSST----------SSRQTRPS----------------------------------- ------------------------------------------------------------ ----L-----------A-------------------------------------SQ---- ------------------------------------------------SRAA-------- -------------------------------------------------------TRIVS H-TEKKYDLLPSKM--SQTELPRKVPSSSSS----------------------------- ----------KSRQSVSDEEDDY---NSEYDQKEMEE---------------KPTS-LAA KW-SPSL-SRGNKNTYD------------------------------DTASNKRKSMDTL L-------------------------------------------------------PHKL ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------------G S----------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------EEEEKE------- ------------------------------------------------------------ ---------------------------------------ETPTL---------------- ----------------------------------------------------------KI SSPES------------------------------------------------------- ------------------------------------------------------------ ---------------------------P-------------------------------- ------------------------------------------------------------ ------------------------------G------------------SS--------- -----------------------------------------------AVAS--------- -RIIH------------S-SNK-HTPSKPSFI--------WPRY---------------- ---SQSTT-------THTVPPTV------------------------------------- ----SSS----------------------------------------------------- -------------------------------TL----------SPRQRLLN--------- ----S----------RLRSPS-----QRQ-------------FV---------------- ------------------------------------------------------------ ---------------------------RPPY------R------Q--------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------GYNGRPNLTTK-------- NGNGK---ILTGNNGKPSGQRVINGPQGTKWIVDLDRGLVLNVEGKYLQDSQGNPLRVKL GGDGRTIVDEKGAPMVSPDGIPLFGHGRFSKPVASAQDKPIISLGGKPLIGLE--MIKKT TTPS-TT---------------------TTTTP--------P--TTT---------T--- --------TT-----------TTT------------------------------------ --------------------------------TTT-------------------TT--TT ----------TTPEP-------------TTTE------------------------PPTE KPPPTCPPGTYAQYDDEGNLLL-GFDGLPECN--------------------------A- ------------------------EVDTFSGLDSEV-------TATP--EAYVIYDD--- ---------------------D--------YEFFE-STL-------L-----P---T--- -------TTTVT-------------------------------------------TT--- --------TTTESEIVYPETSV----------------------V--------------- -----GTGPVSEYDIAGKKRFT--------------------------APYVTYLNKDPA APCSLTEALEHFQVESLDEIIPND--LKEKDTRPLKAPHNITVVAVEGCHSFVIVDWAKP AQGDMVTGYLVYSASYDDFLKNKWSTRTAGTTHLPIENLKPNT----------------- -------------RYYFKVQAKNPFGYGPVSSSVSFITESDNPLLIVRPPG--------- ------GEPIWIPFTFKYDPTYSDCSGKQYVKRTWYRKFVGVVLCNSLRYKIYLSDDL-K -DTFYSIGDSWGRGEDHCQFVDSHLDGRTGPQSYIEALPTIRGYYRQYRQEPVSFGRIGY TTPYYYVGWYECGVPIPGKW---------------------------------------- ------------------------------------------------------ >ENSCJPP00005005729 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------------L--------- ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------GSAVEWD--------P--------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------KDMPSRPLRARAQSP-------------------------------------- -----------------DGRFPFRWRPPYG-AGFRG-------PRGRSQ--IRGYG---- -ESSRRMSY------------APLPQERQNQEARKL---ASESV---------------- ---------HVVSLPSRS-----------------NPGRSQPVYRSSLTKRK-------- ---EEVEVVQDITVRVMSSQSVLVAWTDPQHE-KQ-KAA--AN-RQYNVRYREKGESARW DYKQVSNRRALVENLAPDTMYEFAVQILEGEKEGKWSVSVFQRTPEAAPTSAPENLDVWP LKGKPTSVAASWDALPESEGKVKEYILSYAPALKPFGAKSITYSGATTSAIIDGLQAGER YIFKIRAANRRGPGPQSKAFSVAIPA---------------------------------- ------------------------------------------------------------ GKQQMSLSSKQSS-VHSPGVG--------------------------------------- ---------------DKKSLLSEYKNKILSRGGVPSKSQLPSRKTGEL-ERNLQS----T EVTE---------DHNSSEEAPVTLPK-------------AQD----------------- -----------HRRIVRPPSSSRTIHPVLASGRTPVRTHTSEVSRQTTTEK-REPS---- --------------------------------------------ALSP-----------S QAQR---------------------------------------SSASSVPKYSDN----- --------ETKHLRQSNTNV----------------------------------PSPK-- -------------------------------------------------ASSQSL----- --PAKNNDLSSSME---------------------------------------------- ------------------------------------------EKPDPLL----------- ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------VKVPSKTSEPGLLGLPSNRQ AVVTHEVDPSH------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------PSISLPKKTFSSHL-------------------------PSQ------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------QTQKTSRSEPLQ-KV------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------LHSR-------------------- ---------------GR-----------------------------------RLPS---- ---------------------------P-------------------------------V SS---------------------------------------------------------- --------------------HSNEE----------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ DD---------------------------------------------------------- ----------ED------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------------VTEDSDRASS RSGFPKEVSTSRGLPTSFSQGSSSSSLSKQQQP--------------------------- ------GSQV-------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ----------------------PSYKSKLTQPDSS------------------------- ------------------------------------------------------------ ----------------------------SASGKAKDNQ---------------------- -----------------------------------------------------------Y NSKLSST----------SSRQTRPS----------------------------------- ------------------------------------------------------------ ----L-----------P-------------------------------------SQ---- ------------------------------------------------SRAA-------- -------------------------------------------------------TRMVS H-TEKKIDLLPSKM--SQTELPRKVPSSSSS----------------------------- ----------KSHQSVSDEEDDY---NSEYDQKEMEE---------------KPTS-LAA KW-SPSL-SRGNKNTFD------------------------------DTVSNKRKSMDTL L-------------------------------------------------------PHKL ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------------G S----------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------EEEDKE------- ------------------------------------------------------------ ---------------------------------------ETPTL---------------- ----------------------------------------------------------KM SSPES------------------------------------------------------- ------------------------------------------------------------ ---------------------------P-------------------------------- ------------------------------------------------------------ ------------------------------G------------------SS--------- -----------------------------------------------AVAS--------- -RIIH------------S-SNK-HTPSKPSFI--------WPRY---------------- ---SQSTT-------THTVPPTV------------------------------------- ----SSS----------------------------------------------------- -------------------------------TL----------SPRQRLLN--------- ----S----------RLRSPS-----QRQ-------------FV---------------- ------------------------------------------------------------ ---------------------------RPPY------SVFPSLVS--------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------GYNGRPNLTTK-------- NGNGK---ILTGNNEKPSGQRVINGPQGTKWIVDLDRGLVLNVEGKYLQDSQGNPLRVKL GGDGRTIVDEKGAPMVSPDGIPLFGHGRFSKPVASAQDKPIISLGGKPLIGLE--MIKKT TTPS-TT---------------------TTTTP--------T--TTT---------T--- --------TT-----------TTT------------------------------------ --------------------------------TTT-------------------TT--TT ----------TTPEP-------------TTTE------------------------PPTE KPPPTCPPGTYAQYDDEGNLLL-GFDGLPECNGI---------------TFSFCVSFE-- ------------------------------------------------------------ ---------------------D--------YEFLE-STL-------L-----P---T--- -------TTTVT-------------------------------------------TT--- --------TTTESEIDFPETSV----------------------V--------------- -----GTGPVSEYDIAGKKRFT--------------------------APYVTYLNKDPA APCSLTEALEHFQVESLDEIIPND--LKEKDIRPLRAPHNITVVAVEGCHSFVIVDWAKP AQGDMVTGYLVYSASYDDFLKNKWSTRTAGTTHLPIENLKPNT----------------- -------------RYYFKVQAKNPFGYGPVSSSVSFITESDNPLLIVRPPG--------- ------GEPIWIPFTFKYDPTYSDCSGKQYVKRTWYRKFVGVVLCNSLRYKIYLSDDL-K -DTFYSIGDSWGRGEDHCQFVDSHLDGRTGPQSYIEALPTIRGYYRQYRQEPVSFGRIGY TTPYYYVGWYECGVPIPGKW---------------------------------------- ------------------------------------------------------ >ENSCPRP00005025659 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------------M-------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------A------- ---------------------------------AAR------------------------ ------------------------------------------ASLLPCVALLLLLLLLPA ACPASPEKDMPSRPLRMRMRSS-------------------------------------- -----------------DDKSPVRWRSPHS-SGLRS-------PH-RLQRYPFGYG---- -ESRRKMSY------------SSLSKDQRNQEAKKL---ASESV---------------- ---------YVVSVPSRN-----------------SQGRNQPLYRSALTKRKVTEE---- ---EELEVAKDISVRVMSSQSVLVAWTDPVYE-KQKKVV--AT-RQYTVRYREKGESARW DYKQVPNRRVLVDNLMPDAMYEFAVRISEGEKEGMWSVSVYQRTPETAPASAPENLDVWP VSGKPTSVTASWEPLSESEGKVKEYILSYAPALKPFGAKSITYPGSTTSAIIDGLQPGER YIFKIRAANRRGQGPQSKAFSVAIPA-----------T-IRGDLDVHQKTNFQDDLESKK SGNAA-------------------------------------------PSSPSQTS---- -------------------VSSQ-----------------KL----STSSKHTAA----- ------HSSSSVTGTDKNSHLSEFKNKLLAGSGVLNKSQLSSKKTAEL-EPDPQA----T EVTD---------EHDSSNESPTTLPK-------------TQD----------------- -----------QRRHVRLLSPSRPFHSVHSSGRMPVRSRTPSLTRQTNTDK-HGSS---- --------------------------------------------S--T-----------S SSQRF----------------------------------SSSSSASSSIPKYTDN----- --------ETKRLRQDNPNT----------------------------------PPP--- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------PK-----------------------NPSDSLAGENVHNDLLDS VKEKQAKLDSVPFKDTGSSKTPSRNLEHT----------------------HLALPSSRQ SAVSHKVVKSH------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -------------------------RTKPDPASGPVE----------------------- -----------------------------LPT-------------------SSSP----- --------NSQS--HSHHPSSKLVHSHNDYDSKETRDRDENSN----------------- -------SR---------------------------FSSHDGGSS--------------- ------------------------------------------------------------ ------------------PSPQKRLPTGSKPHVSRDPNFATA-----------------A VSARTAVSVSASHSSAHSRFPF------------------------------SANHKSV- ---------------------------------------------------GRDVS---- ----------------------------------NDGDTD----SEGSEAEHEKKRPD-- SSVFRSRSSLGQSTSERFNLPRYKSSQTANRFLNRVGISPESKLQPSKS---PYS---TV SSKVH------------------------------------------------------- --------------------PQSSGHLTSSS----------------------------- --RSSSNTDK--------------------------ELEEEKPLP-------------ST ------------------------------------------------------------ ---------------------ITHDP-S------------------------------PS T------------------SRESS-AIYSKRRSSQVDVSTHHREPH-------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------HSSS---------------------------------------- -----------------------------------------------------ED----- -----EH---------------------------HGRETEATP--TSHSLSTVRQS---- -------PLPGQSSSSARTNHQVTSVQDPRSRTSSSSSASTGSSSGSATSKHQHGEKDKK EVKGILAKSKQTMPLSKKPLTESSHFSSQKTLHSEP------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------------S SSQRARPSQSQL----QSSLNSR------------------------------------- -------------------DQSNEKL---QED---------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ED---------------------------------------------------------- ----------VV------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------------EKEVGDRVYG RSVFPKEISSKR-IPTSLSQGSSTSSLSKQQQS--------------------------- ------GSQTSN---AEEKHKSRQDPITSFRGSSSSL----------------------- -------------------------------P----------VSRHTGS----------- ------RVTTSGKQMPDSH----------------------------------------- ---------------------KPSSSYKHTRPDTD------------------------- ------------------------------------------------------------ ----------------------------SLSDA--------------------------- ------------------------------------------------------------ ---------------------SRPSQH---------------------------SR---- -------------------------DTSLSSKS-----------------------SSTS MRPNH-----------P-------------------------------------TR---- ---------------------------------------------HSYSRIP-------- -------------------------------------------------------TRTAS R-TEKKY-----------------------SQFLPKPSKVE------------------S SPKDHSLSLPKSRQTVSNEDDD----YSEHDQREVEE---------------KPTSSSAA RW-SSSI-SRGK------------------------------------VASDKRKMMESV L-------------------------------------------------------PRKV ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------------S S----------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------VEEEHE------- ------------------------------------------------------------ ---------------------------------------E-------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------GEGVEPPHLKHSLPASSASSA--------- -----------------------------------------------SVAS--------- -RVSQ------------SPSRQ-HTPSKPSLV--------WPHL---------------- ---SPSMSGPSQPHPTHAASPTI------------------------------------- ----SSSSS--------------------------------------------------- ------------------------------PSL----------SPRQRLLN--------- ----S----------RLRSPS-----QRQ-------------FI---------------- ------------------------------------------------------------ ---------------------------RPPY------R------Q--------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------GYNGRPNLTTKT------- NGNGK---PLSGNNGKPTGQKIIYGPQGTKWIVDLDRGLVLNTEGRFLQDSQGNPLRVKL GGDGRTIVDEKGAPLVSPDGLPLFGHGRFSKPVANAQDKPIISLGGKPLIGLE--MVKKT TPPP-TT---------------------TT--P--------T--TTT---------T--- --------TT-----------TTT------------------------------------ --------------------------------ATTT----------------TTTT--TT ----------TTPEP-------------TTTE------------------------PPTE KPQPTCPPGTYAQYDDDGSLVL-GFDGLPECS--------------------------L- ------------------------E-DSFSGMDSDV-------TATP--EAYVIYDE--- ---------------------D--------YEFFE-STL-------L-----P---T--- -------TTTIA-------------------------------------------TTT-- ST------TEAVPEIVYPETSV----------------------V--------------- -----GSGPLSEFDLAGKKRFT--------------------------APYVTYLNKDPA APCSLTEALEHFQVESLDELIPSD--LKEREMLPQKAPYNITVVAVEGCHSFVIIDWAKP LQGDMVTGYLVYSASYDDFLKNKWSTRTAGTTHLPIENLKPNT----------------- -------------RYYFKVQAKNPYGYGPVSSSVSFVTESDNPLLIVRPPG--------- ------GEPIWIPFTFKYDPTYSDCSGKQYVKRTWYRKFVGVVLCNSLRYKIYLSDDL-K -DTFYGIGDSWGRGEDHCQFVDSHMDGRTGPQSYVEALPTIRGYYRQFRQEPVSFGRIGH TTPYYYVGWYECGVPIPGKW---------------------------------------- ------------------------------------------------------ >ENSPSIP00000008048 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------------MSGRARRRR QREGAGEAAASLSHEGKWRGSKAEQCHWAGRGAAARSARDSSSASSAPAERVARVQPGGS EGRTRDGPTPAPW---LRLAGGXXXXXXXXXXXXXXXXXLHGAS---------------- --PAAPEKEVPHKPLRARVRSP-------------------------------------- ------------------DKLPVRWKLPQS-SRLRS-------PR-RSQGYLLGYG---- -ESSRKMSY------------VPLQKYERNHEAKKL---ASESV---------------- ---------YMVSLQSRN-----------------SQRRSQPVYRAALTKRKISEE---- ---DELEEAKDISVRVMSSQSVLVAWTDPIYE-KQKKVE--AT-RRYAVRYREKGESARW DYKQVPNRRVLVDKLIPDTMYEFAVQISEGEREGKWSASVYQRTPEAAPASAPENLDVWP IKGKTTSVTASWEPLAESEGKVKEYILSYAPALKPFGAKSITYRGGTTSAIIDGLQPGER YIFKIRAANRRGQGPQSKAFSVIMPT-----------A-SRDDLNVHQQTNTQDNTESKK PGDAA-------------------------------------------PSSPPQIFPASS QKIQPSASSKHT--VHS------------------------------------------- --------SSSLGGGDSKNPLSEFKNKLFNSHGVLNKSQLFSKKTSER-EPDPQS----T EVTD---------DHDSSNETPTPLPK-------------MQD----------------- -----------QRRIIGPHSPSRTFHSVLSSGRMPLRLRTPVRARQTSTDK-HGSS---- --------------------------------------------S--S-----------S LTQHS----------------------------------SSSSSASSPIPKYTDN----- --------ETPRQGQENSNT----------------------------------LAS--- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------PK-----------------------IPLDNLPPENVPHDTAGS VEEKQVSLDSVPLKKTGSSRVSPKIPEHT----------------------HLTLPLHRQ SAVSRKMVQSHQTKSHISSMP-----IKSPT----------------------------- --------------SSTVTSSQSHSRYPSSKVVHSGTRDSYDNYDSKEAERRNDRSSSSS SSHDGDSLPSLQTKLHSGSSPQMLKDPKLATAA--------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ASSQSAISASAHHTSTNSHIPS------------------------------SAKLKID- ---------------------------------------------------GR------- ---------------------------------------DDDNYSENTETEEEKKRQDAS SFRFNSRPSLGQTASERLNLLKHKSSQTGNMFLSKISNNQDSKLHPSKP---PYS---AV SSKVH------------------------------------------------------- --------------------SQMNAHRTSTSV---------------------------- -SRPSSNIDGDTRE---------------------LEGEDEKPLP-------------ST ------------------------------------------------------------ ---------------------IAHGH-S------------P-----------------SL S------------------RQSSSVAVYSRRSSPLVESRTHRKVPVKEKSQLFGSEDEL- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------------------NTET EE----IP---------------------------------------------------- ------AKSKQGIPLSKNPSNGVSRFSSQKTLPSEP------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------------S TSQKAHVGQSQR----QFSLNSRG-------------RR--------PSQ---------- -----------------IFPKRNEKL---QEDVAEEEE---------------------- ------------------------------------------------------------ -----------------------------------------------------------A D----------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------------------DRINA HSEFAKDVSSSKRMSTSFSPGSSNSSLSKLQQS--------------------------- ------ISQIST---VDENQKSRHNSPTSSRGSSSSL----------------------- -------------------------------P----------AGRSIGS----------- ------RIASSSEHVLDSYK---------------------------------------- ---------------------SSSSQSQPAESGSR------------------------- ------------------------------------------------------------ ----------------------------SVTDTAKDNHN--------------------- ------------------------------------------------------SRVTSL SSKS-------------SLRQTHPS----------------------------------- ------------------------------------------------------------ ----V-----------P-------------------------------------NY---- ---------------------------------------------HSGSRVP-------- -------------------------------------------------------TKITP K-NERKDGPLQSPP--TKVELSPKVHFSSLS----------------------------- ----------KSHQSVSKDDDD------DYDAGEVEE---------------KPTLSSSA RG-SSSSNSRGRININD------------------------------GGTRDKRKPIDSR L-------------------------------------------------------IHKV ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------------N AA---------------------------------------------------------- ----------------------------E------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------EKEEEEE------- ------------------------------------------------------------ ---------------------------------------ELPTL---------------- ----------------------------------------------------------KQ SLPVS------------------------------------------------------- ------------------------------------------------------------ ---------------------------Q-------------------------------- ------------------------------------------------------------ ------------------------------G----------------RSSS--------- -----------------------------------------------SVVS--------- -RVSQ------------S-PNKPHASSKPRLA--------WPRS---------------- ---SASIYMPSQLHPTHTASLAL------------------------------------- ----SSPTS--------------------------------------------------- -------------------------------PP----------VPRQRLQS--------- ----S----------KLQNLS-----QRQ-------------FV---------------- ------------------------------------------------------------ ---------------------------RPPY------R------Q--------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------GSNGRPNLTTKT------- NINGK---ILPGNNGKPNGQRIINGPRGTKWIIDLDRGLVLNTEGRYLQDSQGNPLRVKL GGDGRTIVDAEGAPVVSPDGLPLFGHGRFSKPLLSAQDKPIVSLGGKPLIGLE--MIKKT TTPS-TT---------------------TTTVP--------------------------- ---------T-----------TTT------------------------------------ -----------------------------------------------------TPT--TT ----------TTPDP-------------TTTE------------------------PPTK KPLPVCPPGTDAQYDEEGKLAL-GPDGLPKCN--------------------------A- ------------------------E-DTFSGMDVEV-------TATP--EAYVIYDE--- ---------------------D--------YEFFE-STL-------P-----P---T--- -------TTVVT-------------------------------------------TTT-- AAATS-STIEAVPDMDYPEISV----------------------A--------------- -----GSDPMSEFDLAGKKRFI--------------------------APYVTYLSKDPA APCSLTEALEHFQVESLDEIIPYH--LKGEEQRPQTVPHNITVVAVEGCHSFVIVDWAKP RQGDLITGYLVYSASYDDFIRNKWSTRTAGATHLPIENLKPNT----------------- -------------RYYFKVQAKNPYGYGPISSSVSFVTESDNPLLIVRPPG--------- ------GEPIWIPFTFKYDPTYSDCSGKQYVKRTWYRKFVGVVLCNSLRYKIYLSDDL-K -DIFYGIGDSWGRGEDHCQFVDSHMDGRTGPQSYVEALPTIQGYYRQYRQEPVSFGRIGY TTPYYYVGWYECGVPIPGKW---------------------------------------- ------------------------------------------------------ >ENSCABP00000030898 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------------IL-------- -------------------NA-LLILM--------------------------------- ------------------------------------------------------------ -------------------------ENVQLLPTKKGLKVMWDTPNKTTGRPM----EQYN ------------------------------------------------------L-VYGE S-----------------------------------------------LK---------- -----------KCKYI-------------------------------------------- -----------CHILSSGVIGVNHLVYRADGPP--------------------------- -------------------------------------------------------GKFII WY---------------------------------------------------------- --------------------------------------FCVFSC---LFFE--------- ------------------------------------------------------------ ------------------------------------------------------------ ------EKEVPNKPLRVRVRSP-------------------------------------- -----------------GNKLSGRWKLPQA-SGLRS-------PR-RPHGYLLDYG---- -ESSRKMSY------------VPLQKHERSQEAKKL---ASESV---------------- ---------YVVSLQSRN-----------------SQRQSQPVYSAALTKRKVSEE---- ---DELEEAKDISVRVMSSQSVLVAWTDPIYE-KPKNVD--PT-RRYAVRYREKGELARW DYKQVPNRRVLVDKLIPDTMYEFAVRISEGEREGKWSASVYQRTPEAAPASAPENLDVWP VKGKTTSVTASWDPLAESEGKVKEYILSYAPALKPFGAKSITYRGGTTSAIIDGLQPGER YIFKIRAANRRGQGPQSKAFSVIMPT---------------------------DNMESKK PGDDV-------------------------------------------PSSPSRTFPVPS RKIQPSASSKHTA-IHS------------------------------------------- --------SSSPSGGDTKSPLSEFKNKLLTGSGVLNKSQLFSKKTSER-EPDPQF----T EVTD---------DQDSSVEMPTPLPK-------------TQD----------------- -----------QRRNIGPYSPSRPFPSVLSSGRTPVRPRTPVRTRQMSTDK-HGSS---- --------------------------------------------S--S-----------S LSQR------------------------------------SSSSASSPISKYTDN----- --------ETKH------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------------S VEEKQVSLDSVPLKKTGSSQVSPKTPEDT----------------------RLALPLNRQ PSVSHKVAQSHQTK---------------------------------------------- -------------------------------------------------------SSSSS SSHDGASLLSLQTKLLSGSNPHMLKDPKLATAA--------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ASSQSAVSASASHTLTNSRIPS------------------------------SAKRKSD- ---------------------------------------------------GRDV----- ---------------------------------------DDGNYSEDTETEGEEKRQDFS SSRFNSRSILGQTASERFNLLKHKSSHTINKFPNKISSSQESKLPPSKP---PYS---AV SSKVH------------------------------------------------------- --------------------PQTNARLTSTSA---------------------------- -TRSSSNIERDTRE---------------------LEGEDEKPLP-------------ST ------------------------------------------------------------ ---------------------IAHDH-S------------P-----------------SS S------------------RLSSSAAVYSRRRNPSVESSVHRREPVKEKSRLPGSEDELL STEIKETLTKSGSLLTVRRSSSLPSISGRSPSST-------------------------- ----------------------------------------------------------KT ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------NH---HSSP---------------------------------------- ------------------------------------------------------------ -------------------------------------------------------S---- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------GSSSSSLSKLQQS--------------------------- ------VSQISK---VDEKHKSSHDSPTSSRGSSSSL----------------------- -------------------------------P----------ADRHVGS----------- ------RVATSNGQVSDSYKQF-------------------------------------- ---------------------SSSYQSKPSQPGSS------------------------- ------------------------------------------------------------ ----------------------------SITDTAKDNQN--------------------- ------------------------------------------------------SRDTSL SSKSSST----------SLRQTHPS----------------------------------- ------------------------------------------------------------ ----V-----------P-------------------------------------NY---- ---------------------------------------------HSGSRVP-------- -------------------------------------------------------TRIAF K-SEKKYGPFQSQP--SKVEPSPKAPFSSIS----------------------------- ----------KSHQSGSKDDDD--------DEGEVEE---------------KPTLSSAA RW-SSSSNSRGSTNMNG------------------------------NGARDKRKPM--- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------G----------------RLLS--------- -----------------------------------------------SVVS--------- -RISQ------------I-PNKPHTSSKPRLV--------WPRS---------------- ---SASTSVPSQLYPTRSASPTL------------------------------------- ----TSSSS--------------------------------------------------- -------------------------------PL----------VPHQRLQ---------- ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------R------Q--------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------RNLSQRQFNTEYIVF----------------SISGSNGRPNLTTKT------- NINGK---ILPGNNGKLSGQRIINGPQGTKWIVDLDRGLVLNAEGRYLQDSQGNPLRVKL GGDGRTIVDAGGAPVVSPDGLPLFGHGRFSKPLASAQDKPVVSLGGKPLIGLE--MIKKT TTSS-TT---------------------TTTIP--------P--TTT---------T--- --------AT-----------TTT------------------------------------ -----------------------------------------------------TTI--TT ----------TTPEP-------------TTTE------------------------LPTE KPLPTCPPGTDAQYDEEGKLVI-GLDGLPECN--------------------------A- --------------------------------------------------------E--- ---------------------D--------FEFFE-STL-------P-----P---T--- -------TTKIT-------------------------------------------TAT-- AA--T-ATTEAVPETDYPEISV----------------------A--------------- -----GSDPMSEFDLAGKKRFT--------------------------APYVSYLSKDPT APCSLTEALEHFQVESLDEIIPYN--LKEGELRPQTVPYNITVVAVEGCHSFVIVDWTKP RQGDLITGYLVYSASYDDFIRNKWSTRTAGATHLPIENLKPNT----------------- -------------RYYFKVQAKNPYGYGPISSSVSFVTESDNPLLIVRPPG--------- ------GEPIWIPFTFKYDPTYSDCSGKQYVKRTWYRKFVGVVLCNSLRYKIYLSDDL-K -DTFYGIGDSWGRGEDHCQFVDSHMDGRTGPQSYVEALPTIQGYYRQYRQEPVSFGRIGY TTPYYYVSWYECGVPIPGKW---------------------------------------- ------------------------------------------------------ >ENSPVIP00000012721 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------W------------------- --R-------------------------------------------VLTKRD-------- ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------PP--------------------------- -------------------------------------------------------G---- ---AGIGKVTL----------------F-------------------------------- --------------------------------------VSLCVF---TFFE--------- ------------------------------------------------------------ ------------------------------------------------------------ ------EKEVPSRPLRVRVRSPL------------------------------------- ---------------STPDRPPVRWRLPHS-SGARS-------PR-RYPSYLSRYG---- -ESSRKMSY------------KPLPKEERNHEIKKL----SESFCYPSLTSSCTLQDDIS NIFIIAHCHYL-----------------------------------------VSEE---- ---DELEEAKDITIRVMSSQSVLVTWTDPVYE-KQKKTV--TS-RQYTVRYREKGESARW DYKKIPNRRVLVDKLIPDTMYEFAIQISEGEREGKWSASVYQRTPEAAPTSAPENLNVWP IKGNTPSVAASWDALSESEGKVKEYILSYAPALKPFGAKSISYSGDTTSALVDGLQPGER YIFKIRAANRRGQGPQSKAFSVVLPA-----------E-STDELNVDQQTHTED------ --------------------------------------------------SEPQPNSS-S QELSQTLSSKHTS-VQ-------------------------------------------- -------LSSLPGGRDSKSSISDLKKKLPAGNRNPTKKQLSSRKDAEL-KGDSHS----T RDTV---------GHHAKKEIATEQPK-------------TQDIKSS------IN----- --------TGKQRS---------------------------------------------- ----------------------------------------------LP-----------S S------------------------------------------SSSSAVPKYTEN----- --------ETKSLRLDSSNF----------------------------------PSS--- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------SE-----------------------VTLDNPPVDNESNDEIDS TEEKHIS--------------------HS----------------------------DEQ HSVSRKVVQSHPPK-----LPTLSVSVKSPTLPAVAGNP----------HHPSYKLVPVD TSDPSEKSSGRDSLK------------------------------------REQKPSSRP Q----------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------GGSS--------------- ------------------------------------------------------------ ------------------PSMQARPLSHSNRQAVRDPRVAT------------------- ----SAVSAAATHTLPHSYRPS------------------------------STKHRPS- ---------------------------------------------------GRE------ -------------------------------------DFDDKDNEGDENEEGKENKRGLL SSRSSSRASLGQTVSERVDLLKHRSALTTNRLANRGSNTHDTRIQPSKD---SSI---VE SSKVH------------------------------------------------------- --------------------PHASSHQTTGR----------------------------- -STSSSDSDK---N---------------------LQDVDETPLP-------------ST ------------------------------------------------------------ ---------------------LSHGN-S------------P-----------------SF P------------------K--SS-VEYSRRRNPQVESK---KEIHSEEK---------- ------DATNTDSL---------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------HEAQGTSPSTRSVPRTSVGKSSPLRSPASKYQPDDLE SKDI-------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -----FLKPKEASPLPKKILTGGSHALSRKTPHPETSH-HSQS----------------- ------------------------------------------------------------ ---------------------------------------------------QPS------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------L------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------NLRTQPTLIPL----------- --------------------QSNENM----ED---------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ED---------------------------------------------------------- ----------EDN-------------LEEN----------------------Y------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------NKEASDMKKQKNS HSVPAKEVSTRRRVSTSLSRESTSA----------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------LSKHSDSHTSKSGEKSPAQ-----HEPLTSSRRLTLPPG QRTGLKVITSSEDLFDIYKLPASSHQSKYVEPEST------------------------- ------------------------------------------------------------ ----------------------------FSKDTVKDHQH--------------------- ------------------------------------------------------SRDTAL FSKPPST----------SLRQTHPS----------------------------------- ------------------------------------------------------------ ----LS--------RYP-------------------------------------SV---- ------------------------------------------------SRVP-------- -------------------------------------------------------SRTAS Q-TGKKYGLPEPAS--TKTE---HFPKTTSS----------------------------- ----------KTHQSFPSHDDD-----EDYDQSETKE---------------NPKASLSA RWPSSSV-SRGSKNLNN------------------------------NT----------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------GNGGRPNLTTKL------- DQNNK---ISPGNNGKRHGQKLINGPQGTKWIVDLDRGLVLNVEGRYLQDSEGKPLRVKL GGDGRTIVDSKGAPIVSPEGLPLFGHGRFSKPVANAQDKPIISLGGKPLIGLE--MIKRT TTPS-TT---------------------T------------------------------- ---------T-----------TTT------------------------------------ --------------------------------TTTA----------------TTTT--TT ----------TTPEP-------------TTTE------------------------PPTE KPLPTCPPGSYPEYDEEGNLAIFNFSGLNVCT-LKFSGPVYLLLSLSANSFSFCL----- ------------------------------------------------------------ ---------------------D--------YEFFE-TTL-------P-----P---S--- -------TT----------------------------------------------TTV-- AT----TTTEVLPETTFPEFSV----------------------T--------------- -----GSDPLSEFDAAGKKRFT--------------------------APYVTYLNKDPG APCSLTEALDHFQVESLDEIIPND--LKNKEMRPQNVPHNITVVAVEGCHSFVILDWAKP IHGDLVTGYLVYSASYDDFIKNRWSTKTAGSTNLPIENLKPNT----------------- -------------RYYFKIQAKNPYGYGPMSSSISYVTESDNPLLIVRPPG--------- ------GEPIWIPFSFKYDPTYSECSGKQYVKRTWYRKFVGVVLCNSLRYKIYLSDDL-R -DTFYSIGDSWGRGEDHCQFVDSHLDGRTGPQSYVEALPPIPGYYRQYRQEPVSFGRIGY MTPYYYVGWYECGVPIPGKW---------------------------------------- ------------------------------------------------------ >ENSNSUP00000021660 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------------LL------- ---------------------SY--DK--------------------------------- ------------------------------------------------LKANSYCIFKNS LELILSSRQEGACSY--------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ --------------------------SFLGAIQKW------------------------- ---------------------------------------------FAIVFL--------- ------------------------------------------------------------ ------------------------------------------------------------ ------KKKVPNRPLRTRFRSS-------------------------------------- -----------------SGRSFLQRRPSHS-AN-AS-------PR-RYPGYLHGYG---- -ESNRKMSF------------KFLPKEERAHYAKKI---ASESV---------------- ---------HLVSPHSRN-----------------FPGRNQPVHQVVLTKRKVPEE---- ---DELEETKDTAVRVMSSHSVLVTWTDPFSE-KQKRPM--SS-RQYTVRYREKGESARW DYKQASIKRVLVDKLNPDTMYEFAVKISQGEREGKWSVSVYQRTPETAPASAPENLNVWS IKGKTPTVVATWDALAESEGKVKEYILSYAPALRPFGAKSISYPGDTTSASVEGLQPGER YIFKIRAANRRGQGPQSKAFSVALPA-----------S-KYRVSITNQQTNIEEDLEPKM SEKIM-------------------------------------------PSSPFLSSSALS QNASPSSSSKHVS-SHP------------------------------------------- --------VAFPEEIDSKIPVSDPKNKVLGS----------SKKEAEL-KMASHS----T K--D---------MVDSVKATSTMQPK-------------VQNVKGSAKSHSII------ ----------------------KPAHSFTSSDKAPLRTRTLVRVGQTNTDK--------- ------------------------------------------------------------ ----------------------------------------PRSLPSSPLPKHTED----- --------ETKNLGQDRPNL---------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------S--------------------------------------------------- ------------------------------------------------------------ -------------------------------------------------------PVLKQ LSASRKTTHNRPTKLRVPSIS-----IKSSS-------PTAAAESEKHSHHFSYKLITPD TSDSPDSDKSRGTEK------------------------------------REQKLNSRV S----------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------SPQGGSS--------------- ------------------------------------------------------------ ------------------PSVQTKPLTYSNHHALRDPKITT------------------- ----SAVSAAATHTLPHSRVLS------------------------------SDKHKSK- ---------------------------------------------------GRD------ -------------------------------------NSDDSENENSERESDEEDKQGSS YSRPNFRPSSGLATSERFDLLKYRSVITSNRFANRATNNHDATMQAPKD---PSA---TQ SSKVH------------------------------------------------------- --------------------PQFSSRLASGSTS-------------------LRSNFNIN KKQGSKN---------------------------------ENPLP-------------ST ------------------------------------------------------------ ---------------------PLHSY-S------------P-----------------PF S------------------KQSSSVDDFKRR----------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------------------SVAET KSHHRIMP---------------------------------------TTNK--------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------PN---- ---------------------------P-------------------------------V NT---------------------------------------------------------- -----------------------------QENNHNKEKE--------------TTDTDSS RISKAKTALSRKMAESIRSSKTLTDWAQVRTSLNSRSDLISLSRNDKELTDND------- ----------------------------------------------------------SS ED---------------------------------------------------------- ----------KETNVKEEQRGSPLTPT--------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----KEVPISRRISTSLSQGRSRS----------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------LSKHFNSRLDRTGERSST----------------PLLPE KQAGSRVITSTEVTSDMHKLPSSSQRFKYVQPIST------------------------- ------------------------------------------------------------ ----------------------------SSKDTIKDYQ---------------------- -----------------------------------------------------------Y NRE---T----------SLKQTRLS----------------------------------- ------------------------------------------------------------ -EPHF-----------P-------------------------------------PE---- ------------------------------------------------SRIS-------- -------------------------------------------------------SRIAS H-INKKHGLFQPTP--TKVELPPKLP----S----------------------------- ----------KIHQSVSNNDDD----YEDYDQSEVEK---------------DPILSSSA KT---------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------SQI--------------------- ------------------------------------------------------------ -------------------SNKLKSLPKLNLT--------LPRI---------------- ---SASVSSHSRL--TSSVSPTH------------------------------------- ----SSA-S--------------------------------------------------- ------------------------------PSV----------PPVQRIQN--------- ----S----------RLLNPF-----QRR-------------QF---------------- ------------------------------------------------------------ ---------------------------RFPH------R------Q--------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------GNGVRPNLTTKI------- DPNNK---IVLNNNGKRNGQKIISGPQGVKWIVDLYRGLVLNAEGRYLQDSQGKPLRVKL GGDGRTIVDSKGAPVVSPDGLPLFGHGRFSKPVANAQDKPIISLGGKPLIGLE--MVKKT TTPY-TT---------------------TTTTT--------P--------------E--- --------PT-----------TTP------------------------------------ --------------------------------EPT------------------TMM--TT ----------TTPEP-------------TTTE------------------------PPTE KPPPTCPPGTHTENDEQGNLVL-DSDGLPECY--------------------------S- ------------------------E-GTLS---------------------YV------- ---------------------D--------YEFFE-TTL-------P-----P---S--- -------TTTTT-------------------------------------------TIT-- -------TTEALPENNFPEFSV----------------------T--------------- -----GTDPLLEYDSAGKKRFT--------------------------APYVTYLNKDPA APCSLTEALDHFQVESLDELVPKN--LKNPGMQPQKTPHNITIIAVEGCHSFVIVDWAAP TYGDLVTGYLVYSASYEDVIRNKWSTKTAANTNLPIENLKPNT----------------- -------------RYYFKVQATNPYGYGPISSSITYVTESDNPLLIVRPPG--------- ------GEPIWIPFNFKYDPTYSECSGKQYVKRTWYRKFVGVVLCNSLRYKIYLSDDL-R -DTFYSIGDSWGRGEDHCQFVDSHLDGRTGPQSYVNALPPIQGYYRQYRQEPVSFGRIGY MTPYYYVGWYECGVTIPGKW---------------------------------------- ------------------------------------------------------ >ENSCATP00000038571 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------MGLKVTWDPPKDATSRPV----EHYN ------------------------------------------------------I-AYGK S-----------------------------------------------MK---------- -----------SLKYIKVNAETYSFLIEDV--------------------------EPGV VYFVLLTAENHS--------GVSRPVYRAESPP--------------------------- -------------------------------------------------------GG--- ---------------------------------EWIEIDGFPIKGPGP------------ ------------------FNETVT------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------EKEVPNKPLRVRVRSS-------------------------------------- -----------------DDRLSVAWKAPRL-SGAKS-------PR-RSRGFLLGYG---- -ESGRKMNY------------VPLTRDERTHEIKKL---ASESV---------------- ---------YVVSLQSMN-----------------SQGRSQPVYRAALTKRKISEE---- ---DELDVPDDISVRVMSSQSVLVSWVDPVLE-KQKKVV--AS-RQYTVRYREKGELARW DYKQITNRRVLIENLIPDTVYEFAVRISQGERDGKWSTSVFQRTPESAPTTAPENLNVWP VNGKPTVVAVSWDALPETEGKVKEYILSYAPALKPFGAKSLTYRGDTTSALVDGLQPGER YLFKIRAANRRGLGPHSKAFIVAVPT-----------T-S--KAEVQQ--NTEDNEKPEK PE----------------------------------------------LSSP---APA-- -------SSQHPS-V--------------------------------------------- --------PASPQGRNAKDLLLDLKNKILANGGAPRKPQLRAKKAEEL---DLQS----T EVTG-------KEELGSREDSRRSPSD-------------TQD----------------- -----------QKRTLRP--PSRHGHAVVAPGRTAVRVRMPALPRREGVDK-PGFSPASH --------PR---------------------------------------PGAPPSASA-S PAHHAATQ---------------------------------------------------- -----------------------------GTSHR--------------------P----- ------------------------------------------------------------ ------------------S-----------LPASFHDN---------------------- ----------------------DLVDSDEDERAVGSPHPKD------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------------------AFAQ PGPALSPSRQSPSSVLRDRSSVHPGAKPASPA-------------------RRTP----- --------H-------------------------SGAAEEDSSASVP------------- ------PSR---------------------------LSPPHGGSSRLLPTQPHRGP---- -------PLSRGGKDGEDTPATNSN---------------APSRSTMS------------ -----------SSVSSR------------------------------------------- ------------------------------------------------------------ LSSRTQVSA------------------------------------------GAEASDGEG DGNVDREDGRRQAEATAQTLRA---------R---------------------------- ------------PASGHYHLLRHKPFAANGRSPNRFGIGRGPRLQPSSS---PQP---TV PSRAH------------------------------------------------------- --------------------PRVHSHPDS------------------------------- HPRLSSGIHGD--------------------------EEDEKPLP-------------AT ------------------------------------------------------------ ---------------------VVNDH-V------------P-----------------SS S------------------RQPVSRGWEALRRSPQRGASLHRKEPIPENP---------- -------------------------------KSA-------------------------- ----------------------------------------------------------GA --------------------------DAHPQGKY-------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------SSLSSKAQDVQQS-TDADTEGHSPKAQ PGSTDRHASPPRP----------------------------------------------- ---------------------------------------------------PAA------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------RSQH----------------- ------------------------------------------------------------ ---------------------------------------------------HPG-PSVPR RMTPGR--------------------APEQQPPSPVSTSQ-HQP-GPQSRDAGQSPSQPR LALA-PARGP---------------------RPTSQ------------------------ ------------------------------------------------------------ ---------------GRSHFSSD------------------------------------- ---------------------------PYT-----------------------------A SS--------------------RGILPTAPQNQ--------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -D---------------------------------------------------------- ----------EDAQG--------------------------------------------- ---------------------------SYDEDST-------------------------- ---------------EVAAQDVRAPAHAAR------------------------------ --------------------------------------AKD------------------- ------------------------------------------------------------ ----------------------AAASLPKHQQV--------------------------- ------ESLTGAGAGGDHRSQHGH------------------------------------ ------------------------------------------------------------ ------------------------------------------------AGSL-------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------ARPSR---------------------------------- ------------------------------------------------------------ ----------------P------------------------------------------- -----------------------GG-------------------PQSRARVP-------- -------------------------------------------------------SRAVP YPGQKEEGAMQATP--GKSEPPSKRPLSS------------------------------- ----------KSQQSVSAE----------------DE-EEEDAGFFKGGKE-DFLSSSVP KWPSSST-PRGGKDADG------------------------------SLAKDERE----- --------------------------------------------------TAIALAP--- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------RGG------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----SL------------------------------------------------------ -------------------APA-------------------------------------- -------------------KRPLPQP-P-------------------------------- ------------------------------------------------------------ ------------------------------G------------------NS--PRASHLP SLPPP-----------RSA----------------------------ATAS--------- ---------------------------------PVAGTHPWPR----------------- --------------YTTRAPPGH------------------------------------- -----ST-T--------------------------------------------------- ------------------------------PML----------SLRQRMMH--------- ----A----------RFRNPL-----SRQ-------------PA---------------- ------------------------------------------------------------ ---------------------------RPSY------R------Q--------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------GYNGRPNV----------- --EGK---VLPGSNGKPNGQRIINGPQGTKWVVDLDRGLVLNAEGRYLQDSHGNPLRIKL GGDGRTIVDLEGTPVVSPDGLPLFGQGRHGTPLASAQDKPILSLGGKPLVGLE--VIKTT THPP-TT-----TTRP---------TTTTTPLP--------T--TTTQRPT-----T--- --------AT-----TRRT--TTT------------------------------------ ---RR-T-TTRR-------PTTTVR--------TTTQ-----------------TT--TT ----------TTPKP-------------TT------------------------------ -PIPTCPPGTLERHDNDGNLIM-SSNGIPECY--------------------------T- ------------------------EEDEFSGLETD--------TAVPTEEAYVIYDE--- ---------------------D--------YE-FE-TSR-------P-----P---T--- -------TTQPS-------------------------------------------TTA-- TTPG-----------VIAEEGA----------------------I--------------- -----SSFPEEEFDLAGRKRFV--------------------------APYVTYLNKDPS APCSLTDALDHFQVDSLDEIIPND--LRRSDLPPQNSPRNITVVAVEGCHSFVIVDWDKA TPGDVVTGYLVYSASYEDFIRNKWSTQASSVTHLPIENLKPNT----------------- -------------RYYFKVQAQNPHGYGPISPSVSFVTESDNPLLVVRPPG--------- ------GEPIWIPFAFKHDPGYTDCHGRQYVKRTWYRKFVGVVLCNSLRYKIFLSDNL-K -DTFYSIGDSWGRGEDHCQFVDSHLDGRTGPQSYVEALPTIQGYYRQYRQEPVSFGNIGF GTPYYYVGWYECGVSIPGKW---------------------------------------- ------------------------------------------------------ >ENSMFAP00000009167 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------------MA-------- ---PEAGATLRAPRR-LSWAA-LLLLAALLPVASSAG-AP-------------------- ------------------------------------------------VDHPL------- -----------------------KPRHVKLLSTKMGLKVTWDPPKDATSRPV----EHYN ------------------------------------------------------I-AYGK S-----------------------------------------------MK---------- -----------SLKYIKVNAETYSFLIEDV--------------------------EPGV VYFVLLTAENHS--------GVSRPVYRAESPP--------------------------- -------------------------------------------------------GG--- ---------------------------------EWIEIDGFPIKGPGP------------ ------------------FNETVT------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------EKEVPNKPLRVRVRSS-------------------------------------- -----------------DDRLSVAWKAPRL-SGAKS-------PR-RSRGFLLGYG---- -ESGRKMNY------------VPLTRDERTHEIKKL---ASESV---------------- ---------YVVSLQSMN-----------------SQGRSQPVYRAALTKRKISEE---- ---DELDVPDDISVRVMSSQSVLVSWVDPVLE-KQKKVV--AS-RQYTVRYREKGELARW DYKQIANRRVLIENLIPDTVYEFAVRISQGERDGKWSTSVFQRTPESAPTTAPENLNVWP VNGKPTVVAVSWDALPETEGKVKEYILSYAPALKPFGAKSLTYRGDTTSALVDGLQPGER YLFKIRAANRRGLGPHSKAFIVAVPT-----------T-S--KAEVQQ--NTEDNEKPEK PE----------------------------------------------LSSP---APA-- -------SSQHPS-V--------------------------------------------- --------PASPQGRNAKDLLLDLKNKILANGGAPRKPQLRAKKAEEL---DLQS----T EVTG-------KEELGSREDSPRSPSD-------------TQD----------------- -----------QKRTLRP--PSRHGHSVVAPGRTAVRVRMPALPRREGVDK-PGFSPASH --------PR---------------------------------------PGAPPSASA-S PAHHAATQ---------------------------------------------------- -----------------------------GTSHR--------------------P----- ------------------------------------------------------------ ------------------S-----------LPASFHDN---------------------- ----------------------DLVDSEEDERAVGSPHPKG------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------------------AFAQ PRPALSPSRQSPSSVLRDRSSVHPGAKPASPA-------------------RRTP----- --------H-------------------------SGAAEDDSSASVP------------- ------PSR---------------------------LSPPHGGSSRLLPTQPHRGP---- -------PLSRGGKDGEDTPATNSN---------------APSRSTMS------------ -----------SSVSSR------------------------------------------- ------------------------------------------------------------ LSSRTQVSA------------------------------------------GAEASDGEG DGNGNREDGGRQAEATAQTLRA---------R---------------------------- ------------PASGHFHLLRHKPFAANGRSPSRFGIGRGPRLQPSSS---PQS---TV PSRAH------------------------------------------------------- --------------------PRVHSHPDF------------------------------- HPRLSSGIHGD--------------------------EEDEKPLP-------------AT ------------------------------------------------------------ ---------------------VVNDH-V------------P-----------------SS S------------------RQPVSRGWEALRRSPQRGASLHRKEPIPENP---------- -------------------------------KSA-------------------------- ----------------------------------------------------------GA --------------------------DAHPQGKY-------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------SSLSSKAQDVQQS-TDADAEGHSPKAQ PGSTDRHASPPRP----------------------------------------------- ---------------------------------------------------PAA------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------RSQH----------------- ------------------------------------------------------------ ---------------------------------------------------HPG-PSVPR RMTPGR--------------------APEQQPPSPVSTSQ-HQP-GPQSRDAGQSPSQPR LALA-PARGP---------------------RPTSQ------------------------ ------------------------------------------------------------ ---------------GRSHFSSD------------------------------------- ---------------------------PYT-----------------------------A SS--------------------RGILPTALQNQ--------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -D---------------------------------------------------------- ----------EDAQG--------------------------------------------- ---------------------------SYDEDST-------------------------- ---------------EVEAQDVRAPAHAAR------------------------------ --------------------------------------AKD------------------- ------------------------------------------------------------ ----------------------AAGSLPKHQQV--------------------------- ------EPPTGAGAGGDDRSQRGH------------------------------------ ------------------------------------------------------------ ------------------------------------------------AGSL-------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------ARPSR---------------------------------- ------------------------------------------------------------ ----------------P------------------------------------------- -----------------------GG-------------------PQSRARVP-------- -------------------------------------------------------SRAAP YSGQKEEGAIQATP--GKSEPPSKRPLSS------------------------------- ----------KSQQSVSAE----------------DE-EEEDAGFFKGGKE-DLLSSSVP KWPSSST-PRGGKDADG------------------------------SLAKDERE----- --------------------------------------------------TAIALAP--- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------RGG------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----SL------------------------------------------------------ -------------------APA-------------------------------------- -------------------KRPLPQP-P-------------------------------- ------------------------------------------------------------ ------------------------------G------------------NS--PRASHLP SLPPP-----------RSA----------------------------ATAN--------- ---------------------------------PVAGTHPWPR----------------- --------------YTTRAPPGH------------------------------------- -----ST-T--------------------------------------------------- ------------------------------PML----------SLRQRMMH--------- ----A----------RFRNPL-----SRQ-------------PA---------------- ------------------------------------------------------------ ---------------------------RPSY------R------Q--------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------GYNGRPNV----------- --EGK---VLPGSNGKPNGQRIINGPQGTKWVVDLDRGLVLNAEGRYLQDSHGNPLRIKL GGDGRTIVDLEGTPVVSPDGLPLFGQGRHGTPLASAQDKPILSLGGKPLVGLE--VIKTT THPP-TT-----TTRP---------TTTTTPLP--------T--TTTQRPT-----T--- --------AT-----TRRT--TTT------------------------------------ ---RR-T-TTRR-------PTTTVR--------TTTR-----------------TT--TT ----------TTPKP-------------TT------------------------------ -PIPTCPPGTLERHDNDGNLIM-SSNGIPECY--------------------------T- ------------------------EEDEFSGLETD--------TAVPTEEAYVIYDE--- ---------------------D--------YE-FE-TSR-------P-----P---T--- -------TTQPS-------------------------------------------TTA-- TTPG-----------VIAEEGA----------------------I--------------- -----SSFPEEEFDLAGKKRFV--------------------------APYVTYLNKDPS APCSLTDALDHFQVDSLDEIIPND--LRRSDLPPQHSPRNITVVAVEGCHSFVIVDWDKA TPGDVVTGYLVYSASYEDFIRNKWSTQASSVTHLPIENLKPNT----------------- -------------RYYFKVQAQNPHGYGPISPSVSFVTESDNPLLVVRPPG--------- ------GEPIWIPFAFKHDPGYTDCHGRQYVKRTWYRKFVGVVLCNSLRYKIFLSDNL-K -DTFYSIGDSWGRGEDHCQFVDSHLDGRTGPQSYVEALPTIQGYYRQYRQEPVSFGNIGF GTPYYYVGWYECGVSIPGKW---------------------------------------- ------------------------------------------------------ >ENSMMUP00000000681 -----------------------------------------M------------------ ------------------------------------------------------------ ----PAGGAQARLKGSAGGRRPQWRSAAAGARP------------------GA------I AAGQGRCGHRVERAEQTDGGGDP----TAAPPHSPDS----GQRP--------------- -----------------------------------SASREHPAPAHPGLPMA-------- ---PEAGATLRAPRR-LSWAA-LLLLAALLPVASSAG-AP-------------------- ------------------------------------------------VDHPL------- -----------------------KPRHVKLLSTKMGLKVTWDPPKDATSRPV----EHYN ------------------------------------------------------I-AYGK S-----------------------------------------------MK---------- -----------SLKYIKVNAETYSFLIEDV--------------------------EPGV VYFVLLTAENHS--------GVSRPVYRAESPP--------------------------- -------------------------------------------------------GG--- ---------------------------------EWIEIDGFPIKGPGP------------ ------------------FNETVT------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------EKEVPNKPLRVRVRSS-------------------------------------- -----------------DDRLSVAWKAPRL-SGAKS-------PR-RSRGFLLGYG---- -ESGRKMNY------------VPLTRDERTHEIKKL---ASESV---------------- ---------YVVSLQSMN-----------------SQGRSQPVYRAALTKRKISEE---- ---DELDVPDDISVRVMSSQSVLVSWVDPVLE-KQKKVV--AS-RQYTVRYREKGELARW DYKQIANRRVLIENLIPDTVYEFAVRISQGERDGKWSTSVFQRTPESAPTTAPENLNVWP VNGKPTVVAVSWDALPETEGKVKEYILSYAPALKPFGAKSLTYRGDTTSALVDGLQPGER YLFKIRAANRRGLGPHSKAFIVAVPT-----------T-S--KAEVQQ--NTEDNEKPEK PE----------------------------------------------LSSP---APA-- -------SSQHPS-V--------------------------------------------- --------PASPQGRNAKDLLLDLKNKILANGGAPRKPQLRAKKAEEL---DLQS----T EVTG-------KEELGSREDSPRSPSD-------------TQD----------------- -----------QKRTLRP--PSRHGHSVVAPGRTAVRVRMPALPRREGVDK-PGFSPASH --------PR---------------------------------------PGAPPSASA-S PAHHAATQ---------------------------------------------------- -----------------------------GTSHR--------------------P----- ------------------------------------------------------------ ------------------S-----------LPASFHDN---------------------- ----------------------DLVDSDEDERAVGSPHPKG------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------------------AFAQ PRPALSPSRQSPSSVLHDRSSVHPGAKPASPA-------------------RRTP----- --------H-------------------------SGAAEDDSSASVP------------- ------PSR---------------------------LSPPHGGSSRLLPTQPHRGP---- -------PLSRGGKDGEDTPATNSN---------------APSRSTMS------------ -----------SSVSSR------------------------------------------- ------------------------------------------------------------ LSSRTQVSA------------------------------------------GAEASDGEG DGNGDREDGGRQAEATAQTLRA---------R---------------------------- ------------PASGHFHLLRHKPFAANGRSPSRFGIGRGPRLQPSSS---PQS---TV PSRAH------------------------------------------------------- --------------------PRVHSHPDS------------------------------- HPRLSSGIHGD--------------------------EEDEKPLP-------------AT ------------------------------------------------------------ ---------------------VVNDH-V------------P-----------------SS S------------------RQPVSRGWEALRRSPQRGASLHRKEPIPENP---------- -------------------------------KSA-------------------------- ----------------------------------------------------------GA --------------------------DAHPQGKY-------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------SSLSSKAQDVQQS-TDADTEGHSPKAQ PGSTDRHASPPRP----------------------------------------------- ---------------------------------------------------PAA------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------RSQH----------------- ------------------------------------------------------------ ---------------------------------------------------HPG-PSVPR RMTPGR--------------------APEQQPPSPVSTSQ-HQP-GPQSRDAGQSPSQPR LALA-PARGP---------------------RPTSQ------------------------ ------------------------------------------------------------ ---------------GRSHFSSD------------------------------------- ---------------------------PYT-----------------------------A SS--------------------RGILPTALQNQ--------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -D---------------------------------------------------------- ----------EDAQG--------------------------------------------- ---------------------------SYDEDST-------------------------- ---------------EVEAQDVRAPAHAAR------------------------------ --------------------------------------AKD------------------- ------------------------------------------------------------ ----------------------AAASLPKHQQV--------------------------- ------EPPTGAGAGGDDRSQRGH------------------------------------ ------------------------------------------------------------ ------------------------------------------------AGSL-------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------ARPSR---------------------------------- ------------------------------------------------------------ ----------------P------------------------------------------- -----------------------GG-------------------PQSRARVP-------- -------------------------------------------------------SRAAP YSGQKEEGAIQATP--GKSEPPSKRPLSS------------------------------- ----------KSQQSVSAE----------------DE-EEEDAGFFKGGKE-DLLSSSVP KWPSSST-PRGGKDADG------------------------------SLAKDERE----- --------------------------------------------------TAIALAP--- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------RGG------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----SL------------------------------------------------------ -------------------APA-------------------------------------- -------------------KRPLPQP-P-------------------------------- ------------------------------------------------------------ ------------------------------G------------------NS--PRASHLP SLPPP-----------RSA----------------------------ATAN--------- ---------------------------------PVAGTHPWPR----------------- --------------YTTRAPPGH------------------------------------- -----ST-T--------------------------------------------------- ------------------------------PML----------SLRQRMMH--------- ----A----------RFRNPL-----SRQ-------------PA---------------- ------------------------------------------------------------ ---------------------------RPSY------R------Q--------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------GYNGRPNV----------- --EGK---VLPGSNGKPNGQRIINGPQGTKWVVDLDRGLVLNAEGRYLQDSHGNPLRIKL GGDGRTIVDLEGTPVVSPDGLPLFGQGRHGTPLASAQDKPILSLGGKPLVGLE--VIKTT THPP-TT-----TTRP---------TTTTTPLP--------T--TTTQRPT-----T--- --------AT-----TRRT--TTT------------------------------------ ---RR-T-TTRR-------PTTTVR--------TTTR-----------------TT--TT ----------TTPKP-------------TT------------------------------ -PIPTCPPGTLERHDNDGNLIM-SSNGIPECY--------------------------T- ------------------------EEDEFSGLETD--------TAVPTEEAYVIYDE--- ---------------------D--------YE-FE-TSR-------P-----P---T--- -------TTQPS-------------------------------------------TTA-- TTAG-----------VIAEEGA----------------------I--------------- -----SSFPEEEFDLAGRKRFV--------------------------APYVTYLNKDPS APCSLTDALDHFQVDSLDEIIPND--LRRSDLPPQHSPRNITVVAVEGCHSFVIVDWDKA TPGDVVTGYLVYSASYEDFIRNKWSTQASSVTHLPIENLKPNT----------------- -------------RYYFKVQAQNPHGYGPISPSVSFVTESDNPLLVVRPPG--------- ------GEPIWIPFAFKHDPGYTDCHGRQYVKRTWYRKFVGVVLCNSLRYKIFLSDNL-K -DTFYSIGDSWGRGEDHCQFVDSHLDGRTGPQSYVEALPTIQGYYRQYRQEPVSFGNIGF GTPYYYVGWYECGVSIPGKW---------------------------------------- ------------------------------------------------------ >ENSTGEP00000000264 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------------MA-------- ---PEAGATLRAPRR-LSWAA-LLLLAALLPVASSAG-AP-------------------- ------------------------------------------------VDHPL------- -----------------------KPRHVKLLSTKMGLKVTWDPPKDATSRPV----EHYN ------------------------------------------------------I-AYGK S-----------------------------------------------MK---------- -----------SLKYIKVNAETYSFLIEDV--------------------------EPGV VYFVLLTAENHS--------GVSRPVYRAESPP--------------------------- -------------------------------------------------------GG--- ---------------------------------EWIEIDGFPIKGPGP------------ ------------------FNETVT------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------EKEVPNKPLRVRVRSS-------------------------------------- -----------------DDRLSVAWKAPRL-SGAKS-------PR-RSRGFLLGYG---- -ESGRKMNY------------VPLTRDERTHEIKKL---ASESV---------------- ---------YVVSLQSMN-----------------SQGRSQPVYRAALTKRKISEE---- ---DELDVPDDISVRVMSSQSVLVSWVDPVLE-KQKKVV--AS-RQYTVRYREKGELARW DYKQIANRRVLIENLIPDTVYEFAVRISQGERDGKWSTSVFQRTPESAPTTAPENLNVWP VNGKPTVVAVSWDALPETEGKVKEYILSYAPALKPFGAKSLTYRGDTTSALVDGLQPGER YLFKIRAANRRGLGPHSKAFIVAVPT-----------T-S--KAEVQQ--NTEDNEKPEK PE----------------------------------------------LSSP---APA-- -------SSQHPS-V--------------------------------------------- --------PASPQGRNAKDLLLDLKNKILANGGAPRKPQLRAKKAEEL---DLQS----T EVTR-------KEELGSREDSPRSPSD-------------TQD----------------- -----------QKRTLRP--PSRHGHAVVAPGRTAVRVRMPALPRREGVDK-PGFSPASH --------PR---------------------------------------PGASPSASA-S PAHHAATQ---------------------------------------------------- -----------------------------GTSHR--------------------P----- ------------------------------------------------------------ ------------------S-----------LPASFHDN---------------------- ----------------------DLVDSDEDERAVGSPHPKG------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------------------AFAQ PRPALSPSRQSPSSVLRDRSSVHPGAKPASPA-------------------RRTP----- --------H-------------------------SGAAEEDSSASVP------------- ------PSR---------------------------LSPPHGGSSRLLPTQPHRGP---- -------PLSRGGKDGEDTPATNSN---------------APSRSTMS------------ -----------SSVSSR------------------------------------------- ------------------------------------------------------------ LSSRTQVSA------------------------------------------GAEASDGEG DGDVDREDGGRQAEATAQTLRA---------R---------------------------- ------------PASGHFHLLRHKPFGANGRSPSRFGIGRGPRLQPSSS---PQS---TV PSRAH------------------------------------------------------- --------------------PRVHSHPDS------------------------------- HPRLSSGIHGD--------------------------EEDEKPLP-------------AT ------------------------------------------------------------ ---------------------VVNDH-V------------P-----------------SS S------------------RQPVSRGWESLRRSPQRGASLHRKEPIPENP---------- -------------------------------KSA-------------------------- ----------------------------------------------------------GA --------------------------DAHPQGKY-------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------SSLSSKAQDVQQS-TDADTEGHSPKAQ PGSTDRHASPPRP----------------------------------------------- ---------------------------------------------------PAA------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------RSQH----------------- ------------------------------------------------------------ ---------------------------------------------------HPG-PSVPR RMTPGR--------------------APEQQPPSPVSTSQ-HQP-GPQSRDAGQSPSQPR LALA-PARGP---------------------RPTSQ------------------------ ------------------------------------------------------------ ---------------GRSHFSSD------------------------------------- ---------------------------PYT-----------------------------A SS--------------------RGILPTALQNQ--------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -D---------------------------------------------------------- ----------EDAQG--------------------------------------------- ---------------------------SYDEDST-------------------------- ---------------EVAAQDVRAPAHAAR------------------------------ --------------------------------------AKD------------------- ------------------------------------------------------------ ----------------------AAASLPKHQQV--------------------------- ------ESSTGAGAGGDDRSQRGH------------------------------------ ------------------------------------------------------------ ------------------------------------------------AGSL-------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------ARPSR---------------------------------- ------------------------------------------------------------ ----------------P------------------------------------------- -----------------------GG-------------------PQSRARVP-------- -------------------------------------------------------SRAAP YSGQKEEGAIQATP--GKSEPPSKRPLSS------------------------------- ----------KSQQSVSAE----------------DE-EEEDVGFFKGGKE-DLLSSSVP KWPSSST-PRGGKDADG------------------------------SLAKDERE----- --------------------------------------------------TAIALAP--- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------RGG------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----SL------------------------------------------------------ -------------------APA-------------------------------------- -------------------KRPLPQP-P-------------------------------- ------------------------------------------------------------ ------------------------------G------------------NS--PRASHLP SLPPP-----------RSA----------------------------ATAS--------- ---------------------------------PVAGTHPWPR----------------- --------------YTTRAPPGH------------------------------------- -----ST-T--------------------------------------------------- ------------------------------PML----------SLRQRMMH--------- ----A----------RFRNPL-----SRQ-------------PA---------------- ------------------------------------------------------------ ---------------------------RPSY------R------Q--------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------GYNGRPNV----------- --EGK---VLPGSNGKPNGQRIINGPQGTKWVVDLDRGLVLNAEGRYLQDSHGNPLRIKL GGDGRTIVDLEGTPVVSPDGLPLFGQGRHGTPLASAQDKPILSLGGKPLVGLE--VIKTT THPP-TT-----TTRP---------TTTTTPLP--------T--TTTQRPT-----T--- --------AT-----TRRT--TTT------------------------------------ ---RR-T-TTRR-------PTTTVR--------TTMR-----------------TT--TT ----------TTPKP-------------TT------------------------------ -PIPTCPPGTLERHDNDGNLIM-SSNGIPECY--------------------------T- ------------------------EEDEFSGLETD--------TAVPTEEAYVIYDE--- ---------------------D--------YE-FE-TSR-------P-----P---T--- -------TTQPS-------------------------------------------TTA-- TTPG-----------VIAEEGA----------------------I--------------- -----SSFPEEEFDLAGRKRFV--------------------------APYVTYLNKDPS APCSLTDALDHFQVDSLDEIIPND--LRRSDLPPQHSPRNITVVAVEGCHSFVIVDWDKA TPGDVVTGYLVYSASYEDFIRNKWSTQASSVTHLPIENLKPNT----------------- -------------RYYFKVQAQNPHGYGPISPSVSFVTESDNPLLVVRPPG--------- ------GEPIWIPFAFKHDPGYTDCHGRQYVKRTWYRKFVGVVLCNSLRYKIFLSDNL-K -DTFYSIGDSWGRGEDHCQFVDSHLDGRTGPQSYVEALPTIQGYYRQYRQEPVSFGNIGF GTPYYYVGWYECGVSIPGKW---------------------------------------- ------------------------------------------------------ >ENSPANP00000002745 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------------MA-------- ---PEAGATLRAPRR-LSWAA-LLLLAALLPVASSAG-AP-------------------- ------------------------------------------------VDHPL------- -----------------------KPRHVKLLSTKMGLKVTWDPPKDATSRPV----EHYN ------------------------------------------------------I-AYGK S-----------------------------------------------MK---------- -----------SLKYIKVNAETYSFLIEDV--------------------------EPGV VYFVLLTAENHS--------GVSRPVYRAESPP--------------------------- -------------------------------------------------------GG--- ---------------------------------EWIEIDGFPIKGPGP------------ ------------------FNETVT------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------EKEVPNKPLRVRVRSS-------------------------------------- -----------------DDRLSVAWKAPRL-SGAKS-------PR-RSRGFLLGYG---- -ESGRKMNY------------VPLTRDERTHEIKKL---ASESV---------------- ---------YVVSLQSMN-----------------SQGRSQPVYRAALTKRKISEE---- ---DELDVPDDISVRVMSSQSVLVSWVDPVLE-KQKKVV--AS-RQYTVRYREKGELARW DYKQIANRRVLIENLIPDTVYEFAVRISQGERDGKWSTSVFQRTPESAPTTAPENLNVWP VNGKPTVVAVSWDALPETEGKVKEYILSYAPALKPFGAKSLTYRGDTTSALVDGLQPGER YLFKIRAANRRGLGPHSKAFIVAVPT-----------T-S--KAEVQQ--NTEDNEKPEK PE----------------------------------------------LSSP---APA-- -------SSQHPS-V--------------------------------------------- --------PASPQGRNAKDLLLDLKNKILANGGAPRKPQLRAKKAEEL---DLQS----T EVTG-------KEELGSREDSPRSPSD-------------TQD----------------- -----------QKRTLRP--PSRHGHAVVAPGRTAVRVRMPALPRREGVDK-PGFSPASH --------PR---------------------------------------PGAPPSASA-S PAHHAATQ---------------------------------------------------- -----------------------------GTSHR--------------------P----- ------------------------------------------------------------ ------------------S-----------LPASFHDN---------------------- ----------------------DLVDSDEDERAVGSPHPKG------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------------------AFAQ PRPALSPSRQSPSSVLRDRSSVHPGAKPASPA-------------------RRTP----- --------H-------------------------SGAAEEDSSASVP------------- ------PSR---------------------------LSPPHGGSSRLLPTQPHRAP---- -------PLSRGGKDGEDTPATNSN---------------APSRSTMS------------ -----------SSVSSR------------------------------------------- ------------------------------------------------------------ LSSRTQVSA------------------------------------------GAEASDGEG DGNVDREDGGRQAEATAQTLRA---------R---------------------------- ------------PASGHFHLLRHKPFAANGRSPSRFGIGRGPRLQPSSS---PQS---TV PSRAH------------------------------------------------------- --------------------PRVHSHPDS------------------------------- HPRLSSGIHGD--------------------------EEDEKPLP-------------AT ------------------------------------------------------------ ---------------------VVNDH-V------------P-----------------SS S------------------RQPVSRGWEALRRSPQRGTSLHRKEPIPENP---------- -------------------------------KSA-------------------------- ----------------------------------------------------------GA --------------------------DAHPQGKY-------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------SSLSSKAQDVQQS-TDADTEGHSPKAQ PGSTDRHASPPRP----------------------------------------------- ---------------------------------------------------PAA------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------RSQH----------------- ------------------------------------------------------------ ---------------------------------------------------HPG-PSVPR RMTPGR--------------------APEQQPPSPVSTSQ-HQP-GPQSRDAGQSPSQPR LALA-PARGP---------------------RPTSQ------------------------ ------------------------------------------------------------ ---------------GRSHFSSD------------------------------------- ---------------------------PYT-----------------------------A SS--------------------RGILPTALQNQ--------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -D---------------------------------------------------------- ----------EDAQG--------------------------------------------- ---------------------------SYDEDST-------------------------- ---------------EVAAQDVRAPAHAAR------------------------------ --------------------------------------AKD------------------- ------------------------------------------------------------ ----------------------AAASLPKHQQV--------------------------- ------ESSTGAGAGGDDRSQRGH------------------------------------ ------------------------------------------------------------ ------------------------------------------------AGSL-------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------ARPSR---------------------------------- ------------------------------------------------------------ ----------------P------------------------------------------- -----------------------GG-------------------PQSRARVP-------- -------------------------------------------------------SRAAP YSGQKEEGAIQATP--GKSEPPSKRPLSS------------------------------- ----------KSQQSVSAE----------------DE-EEEDAGFFKGGKE-DLLSSSVP KWPSSST-PRGGKDADG------------------------------SLAKDERE----- --------------------------------------------------TAIALAP--- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------RGG------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----SL------------------------------------------------------ -------------------APA-------------------------------------- -------------------KRPLPQP-P-------------------------------- ------------------------------------------------------------ ------------------------------G------------------NS--PRASHLP SLPPP-----------RSA----------------------------ATAS--------- ---------------------------------PVAGTHPWPR----------------- --------------YTTRAPPGH------------------------------------- -----ST-T--------------------------------------------------- ------------------------------PML----------SLRQRMMH--------- ----A----------RFRNPL-----SRQ-------------PA---------------- ------------------------------------------------------------ ---------------------------RPSY------R------Q--------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------GYNGRPNV----------- --EGK---VLPGSNGKPNGQRIINGPQGTKWVVDLDRGLVLNAEGRYLQDSHGNPLRIKL GGDGRTIVDLEGTPVVSPDGLPLFGQGRHGTPLASAQDKPILSLGGKPLVGLE--VIKTT THPP-TT-----TTRP---------TTTTTPLP--------T--TTTQRPT-----T--- --------AT-----TRRT--TTT------------------------------------ ---RR-T-TTRR-------PTTTVQ--------TTTR-----------------TT--TT ----------TTPKP-------------TT------------------------------ -PIPTCPPGTLERHDNDGNLIM-SSNGIPECY--------------------------T- ------------------------EEDEFSGLETD--------TAVPTEEAYVIYDE--- ---------------------D--------YE-FE-TSR-------P-----P---T--- -------TTQPS-------------------------------------------TTA-- ATPG-----------VITEEGA----------------------I--------------- -----SSFPEEEFDLAGRKRFV--------------------------APYVTYLNKDPS APCSLTDALDHFQVDSLDEIIPND--LRRSDLPPQHSPRNITVVAVEGCHSFVIVDWDKA TPGDVVTGYLVYSASYEDFIRNKWSTQASSVTHLPIENLKPNT----------------- -------------RYYFKVQAQNPHGYGPISPSVSFVTESDNPLLVVRPPG--------- ------GEPIWIPFAFKHDPGYTDCHGRQYVKRTWYRKFVGVVLCNSLRYKIFLSDNL-K -DTFYSIGDSWGRGEDHCQFVDSHLDGRTGPQSYVEALPTIQGYYRQYRQEPVSFGNIGF GTPYYYVGWYECGVSIPGKW---------------------------------------- ------------------------------------------------------ >ENSMLEP00000024933 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------------DHPL------- -----------------------KPRHVKLLSTKMGLKVTWDPPKDATSRPV----EHYN ------------------------------------------------------I-AYGK S-----------------------------------------------MK---------- -----------SLKYIKVNAETYSFLIEDV--------------------------EPGV VYFVLLTAENHS--------GVSRPVYRAESPP--------------------------- -------------------------------------------------------GG--- ---------------------------------EWIEIDGFPIKGPGP------------ ------------------FNETVT------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------EKEVPNKPLRVRVRSS-------------------------------------- -----------------DDRLSVAWKAPRL-SGAKS-------PR-RSRGFLLGYG---- -ESGRKMNY------------VPLTRDERTHEIKKL---ASESV---------------- ---------YVVSLQSMN-----------------SQGRSQPVYRAALTKRKISEE---- ---DELDVPDDISVRVMSSQSVLVSWVDPVLE-KQKKVV--AS-RQYTVRYREKGELARW DYKQIANRRVLIENLIPDTVYEFAVRISQGERDGKWSTSVFQRTPESAPTTAPENLNVWP VNGKPTVVAVSWDALPETEGKVKEYILSYAPALKPFGAKSLTYRGDTTSALVDGLQPGER YLFKIRAANRRGLGPHSKAFIVAVPT-----------T-S--KAEVQQ--NTEDNEKPEK PE----------------------------------------------LSSP---APA-- -------SSQHPS-V--------------------------------------------- --------PASPQGRNAKDLLLDLKNKILANGGAPRKPQLRAKKAEEL---DLQS----T EVTG-------KEELGSREDSRRSPSD-------------TQD----------------- -----------QKRTLRP--PSRHGHAVVAPGRTAVRVRMPALPRREGVDK-PGFSPASH --------PR---------------------------------------PGAPPSASA-S PAHHAATQ---------------------------------------------------- -----------------------------GTSHR--------------------P----- ------------------------------------------------------------ ------------------S-----------LPASFHDN---------------------- ----------------------DLVDSDEDERAVGSPHPKG------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------------------AFAQ PRPALSPSRQSPSSVLRDRSSVHPGAKPASPA-------------------RRTP----- --------H-------------------------SGAAEEDSSASVP------------- ------PSR---------------------------LSPPHGGSSRLLPTQPHRGP---- -------PLSRGGKDGEDAPATNSN---------------APSRSTMS------------ -----------SSVSSR------------------------------------------- ------------------------------------------------------------ LSSRTQVSA------------------------------------------GAEASDGEG DGNGDREDGGRQAEATAQTLRA---------R---------------------------- ------------PASGHFHLLRHKPFAANGRSPSRFGIGRGPRLQPSSS---PQS---TV PSRAH------------------------------------------------------- --------------------PRVHSHPDS------------------------------- HPRLSSGIHGD--------------------------EEDEKPLP-------------AT ------------------------------------------------------------ ---------------------VVNDH-V------------P-----------------SS S------------------RQPVSRGWEALRRSPQRGASLHRKEPIPENP---------- -------------------------------KSA-------------------------- ----------------------------------------------------------GA --------------------------DAHPQGKY-------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------SSLSSKVQDVQQS-TDADTEGHSPKAQ PGSTDRHASPPRA----------------------------------------------- ---------------------------------------------------PAA------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------RSQH----------------- ------------------------------------------------------------ ---------------------------------------------------HPG-PSVPR RMTPGR--------------------APEQQPPSPVSTSQ-HQP-GPQSRDAGQAPSQPR LALA-PARGP---------------------RPTSQ------------------------ ------------------------------------------------------------ ---------------GRSHFSSD------------------------------------- ---------------------------PYT-----------------------------V NS--------------------RGILPTALHNQ--------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -D---------------------------------------------------------- ----------EDAQG--------------------------------------------- ---------------------------SYDEDST-------------------------- ---------------EVAAQDVRAPAHAAR------------------------------ --------------------------------------AKD------------------- ------------------------------------------------------------ ----------------------AAASLPKHQQV--------------------------- ------EPPTGAGAGGDDRSQRGH------------------------------------ ------------------------------------------------------------ ------------------------------------------------AGSL-------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------ARPSR---------------------------------- ------------------------------------------------------------ ----------------P------------------------------------------- -----------------------GG-------------------PQSRARVP-------- -------------------------------------------------------SKAA- -------------P--GKSEPPSKRPLSS------------------------------- ----------KSQQSVSAE----------------DE-EEEDAGFFKGGKE-DLLSSSVP KWPSSST-PRGGKDADG------------------------------SLAKDERE----- --------------------------------------------------TAIALAP--- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------RGG------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----SL------------------------------------------------------ -------------------APA-------------------------------------- -------------------KRPLPQP-P-------------------------------- ------------------------------------------------------------ ------------------------------G------------------NS--PRASHLP SLPPP-----------RSA----------------------------ATAS--------- ---------------------------------PVAGTHPWPR----------------- --------------YTTRAPPGH------------------------------------- -----ST-T--------------------------------------------------- ------------------------------PML----------SLRQRMMH--------- ----A----------RFRNPL-----SRQ-------------PA---------------- ------------------------------------------------------------ ---------------------------RPSY------R------Q--------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------GYNGRPNV----------- --EGK---VLPGSNGKPNGQRIINGPQGTKWVVDLDRGLVLNAEGRYLQDSHGNPLRIKL GGDGRTIVDLEGTPVVSPDGLPLFGQGRHGTPLASAQDKPILSLGGKPLVGLE--VIKTT THPP-TT-----TTRP---------TTTTTPLP--------T--TTTQRPT-----T--- --------AT-----TRRT--TTT------------------------------------ ---RR-T-TTRR-------PTTTVR--------TTTR-----------------TT--TT ----------TTPKP-------------TT------------------------------ -PIPTCPPGTLERHDNDGNLIM-SSNGIPECY--------------------------T- ------------------------EEDEFSGLETD--------TAVPTEEAYVIYDE--- ---------------------D--------YE-FE-TSR-------P-----P---T--- -------TTQPS-------------------------------------------TIA-- TTPG-----------VIAEEGA----------------------I--------------- -----SSFPEEEFDLAGRKRFV--------------------------APYVTYLNKDPS APCSLTDALDHFQVDSLDEIIPND--LRRSDLPPQNSPRNITVVAVEGCHSFVIVDWDKA TPGDVVTGYLVYSASYEDFIRNKWSTQASSVTHLPIENLKPNT----------------- -------------RYYFKVQAQNPHGYGPISPSVSFVTESDNPLLVVRPPG--------- ------GEPIWIPFAFKHDPGYTDCHGRQYVKRTWYRKFVGVVLCNSLRYKIFLSDNL-K -DTFYSIGDSWGRGEDHCQFVDSHLDGRTGPQSYVEALPTIQGYYRQYRQEPVSFGNIGF GTPYYYVGWYECGVSIPGKW---------------------------------------- ------------------------------------------------------ >ENSMNEP00000040509 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------------MA-------- ---PEAGATLRAPRR-LSWAA-LLLLAALLPVASSAG-AP-------------------- ------------------------------------------------VDHPL------- -----------------------KPRHVKLLSTKMGLKVTWDPPKDATSRPV----EHYN ------------------------------------------------------I-AYGK S-----------------------------------------------MK---------- -----------SLKYIKVNAETYSFLIEDV--------------------------EPGV VYFVLLTAENHS--------GVSRPVYRAESPP--------------------------- -------------------------------------------------------GG--- ---------------------------------EWIEIDGFPIKGPGP------------ ------------------FNETVT------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------EKEVPNKPLRVRVRSS-------------------------------------- -----------------DDRLSVAWKAPRL-SGAKS-------PR-RSRGFLLGYG---- -ESGRKMNY------------VPLTRDERTHEIKKL---ASESV---------------- ---------YVVSLQSMN-----------------SQGRSQPVYRAALTKRKISEE---- ---DELDVPDDISVRVMSSQSVLVSWVDPVLE-KQKKVV--AS-RQYTVRYREKGELARW DYKQIANRRVLIENLIPDTVYEFAVRISQGERDGKWSTSVFQRTPESAPTTAPENLNVWP VNGKPTVVAVSWDALPETEGKVKEYILSYAPALKPFGAKSLTYRGDTTSALVDGLQPGER YLFKIRAANRRGLGPHSKAFIVAVPT-----------T-S--KAEVQQ--NTEDNEKPEK PE----------------------------------------------LSSP---APA-- -------SSQHPS-V--------------------------------------------- --------PASPQGRNAKDLLLDLKNKILANGGAPRKPQLRAKKAEEL---DLQS----T EVTR-------KEELGSREDSPRSPSD-------------TQD----------------- -----------QKRTLRP--PSRHGHSVVAPGRTAVRVRMPALPRREGVDK-PGFSPASH --------PR---------------------------------------PGAPPSASA-S PAHHAATQ---------------------------------------------------- -----------------------------GTSHR--------------------P----- ------------------------------------------------------------ ------------------S-----------LPASFHDN---------------------- ----------------------DLVDSDEDERAVGSPDPKG------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------------------AFAQ PQPALSPSRQSPSSVLRDRSSVHPGAKPASPA-------------------RRTP----- --------H-------------------------SGAAEDDSSASVP------------- ------PSR---------------------------PSPPHGGSSRLLPTQPHRGP---- -------PLSRGGKDGEDTAATNSN---------------APSRSTMS------------ -----------SSVSSR------------------------------------------- ------------------------------------------------------------ LSSRTQVSA------------------------------------------GAEASDGEG DGNGDREDGGRQAEATAQTLRA---------R---------------------------- ------------PASGHFHLLRHKPFAANGRSPSRFGIGRGPRLQPSSS---PQS---TV PSRAH------------------------------------------------------- --------------------PRVHSHPDS------------------------------- HTRLSSGIHGD--------------------------EEDEKPLP-------------AT ------------------------------------------------------------ ---------------------VVNDH-V------------P-----------------SS S------------------RQPVSRGWEALRRSPQRGASLHRKEPIPENP---------- -------------------------------KSA-------------------------- ----------------------------------------------------------GA --------------------------DAHPQGKY-------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------SSLSSKAQDVQQS-TDADTEGHSPKAQ PGSTDRHASPPRP----------------------------------------------- ---------------------------------------------------PAA------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------RSQH----------------- ------------------------------------------------------------ ---------------------------------------------------HPG-PSVPR RMTPGR--------------------APEQQPPSLVSTSQ-HQP-GPQSRDAGQSPSQPR LALA-PARGP---------------------RPTSQ------------------------ ------------------------------------------------------------ ---------------GRSHFSSD------------------------------------- ---------------------------PYT-----------------------------A SS--------------------RGILPTALQNQ--------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -D---------------------------------------------------------- ----------EDAQG--------------------------------------------- ---------------------------SYNEDST-------------------------- ---------------EVKAQDVRAPAHAAR------------------------------ --------------------------------------AKD------------------- ------------------------------------------------------------ ----------------------AAASLPKHQQV--------------------------- ------EPPTGAGAGGDDRSQRGH------------------------------------ ------------------------------------------------------------ ------------------------------------------------AGSL-------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------ARPSR---------------------------------- ------------------------------------------------------------ ----------------P------------------------------------------- -----------------------GG-------------------PQSRARVP-------- -------------------------------------------------------SRAA- -------------P--GKSEPPSKRPLSS------------------------------- ----------KSQQSVSAE----------------DE-EEEDAGFFKGGKE-DLLSSSVP KWPSSST-PRGGKDADG------------------------------SLAKDERE----- --------------------------------------------------TAIALAP--- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------RGG------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----SL------------------------------------------------------ -------------------APA-------------------------------------- -------------------KRPLPQP-P-------------------------------- ------------------------------------------------------------ ------------------------------G------------------NS--PRASHLP SLPPP-----------RIA----------------------------ATAN--------- ---------------------------------PVAGTHPWPR----------------- --------------YTTRAPPGH------------------------------------- -----ST-T--------------------------------------------------- ------------------------------PML----------SLRQRMMH--------- ----A----------RFRNPL-----SRQ-------------PA---------------- ------------------------------------------------------------ ---------------------------RPSY------R------Q--------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------GYNGRPNV----------- --EGK---VLPGSNGKPNGQRIINGPQGTKWVVDLDRGLVLNAEGRYLQDSHGNPLRIKL GGDGRTIVDLEGTPVVSPDGLPLFGQGRHGTPLASAQDKPILSLGGKPLVGLE--VIKTT THPP-TT-----TTRP---------TTTTTLLP--------T--TTTQRPT-----T--- --------AT-----TRRT--TTT------------------------------------ ---RR-T-TTRR-------PTTTVR--------TTTR-----------------TT--TT ----------TTPKP-------------TT------------------------------ -PIPTCPPGTLERHDNDGNLIM-SSNGIPECY--------------------------T- ------------------------EEDEFSGLETD--------TAVPTEEAYVIYDE--- ---------------------D--------YE-FE-TSR-------P-----P---T--- -------TTQPS-------------------------------------------TTA-- TTPG-----------VIAEEGA----------------------I--------------- -----SSFPEEEFDLAGRKRFV--------------------------APYVTYLNKDPS APCSLTDALDHFQVDSLDEIIPND--LRRSDLPPQHSPRNITVVAVEGCHSFVIVDWDKA TPGDVVTGYLVYSASYEDFIRNKWSTQASSVTHLPIENLKPNT----------------- -------------RYYFKVQAQNPHGYGPISPSVSFVTESDNPLLVVRPPG--------- ------GEPIWIPFAFKHDPGYTDCHGRQYVKRTWYRKFVGVVLCNSLRYKIFLSDNL-K -DTFYSIGDSWGRGEDHCQFVDSHLDGRTGPQSYVEALPTIQGYYRQYRQEPVSFGNIGF GTPYYYVGWYECGVSIPGKW---------------------------------------- ------------------------------------------------------ >ENSCSAP00000008788 ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------VDSCAVYI ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------VDHPL------- -----------------------KPRHVKLLSTKMGLKVTWDPPKDATSRPV----EHYN ------------------------------------------------------I-AYGK S-----------------------------------------------LK---------- -----------SLKYIKVNAETYSFLIEDV--------------------------EPGV VYFVLLTAENHS--------GVSRPVYRAESPP--------------------------- -------------------------------------------------------GG--- ---------------------------------EWIEIDGFPIKGPGP------------ ------------------FNETVT------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------EKEVPNKPLRVRVRSS-------------------------------------- -----------------DDRLSIAWKAPRL-SGAKS-------PR-RSRGFLLGYG---- -ESGRKMNY------------VPLTRDERTHEIKKL---ASESV---------------- ---------YVVSLQSMN-----------------SQGRSQPVYRAALTKRKISEE---- ---DELDVPDDISVRVMSSQSVLVSWVDPVLE-KQKKVV--AS-RQYTVRYREKGELARW DYKQIANRRVLIENLIPDTVYEFAVRISQGERDGKWSTSVFQRTPESAPTTAPENLNVWP VNGKPTVVAVSWDALPETEGKVKEYILSYAPALKPFGAKSLTYRGDTTSALVDGLQPGER YLFKIRAANRRGLGPHSKAFVVAVPT-----------T-S--KAEVQQ--KTEDNEKPEK PE----------------------------------------------RSSP---APA-- -------SSQHPS-V--------------------------------------------- --------PASPQGRNAKDLLLDLKNKILANGGVPRKPQLRAKKAEEL---DLQS----T EVTG-------KEELGSREDSPRSPSD-------------TQD----------------- -----------QKRTLRP--PSRHGHAVVAPGRTAVRVRMPALPRREGVDK-PGFSPASH --------PR---------------------------------------PGASPSASA-S PAHHAATQ---------------------------------------------------- -----------------------------GTSHR--------------------P----- ------------------------------------------------------------ ------------------S-----------LPASFHDN---------------------- ----------------------DLVDSDEDERAVGSPHPKV------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------------------AFAQ PRPALSPSRQSPSSVLRDRSSVHPGAKPASPA-------------------RRTP----- --------H-------------------------SGAAEEDSSASVP------------- ------PSR---------------------------LSPSHGGSSRLLPTQPHRGP---- -------PLSRGGNDGEDAPATNSN---------------APSRSTIS------------ -----------SSVSSRLS----------------------------------------- ------------------------------------------------------------ LSSRTQVSA------------------------------------------GAEASDGEG DGNGDREDGRRQAEATAPTLRA---------R---------------------------- ------------PASGHFHLLRHKPFAANGRSPSRFGIGRGPRLQPSSS---PQS---TV PSRAH------------------------------------------------------- --------------------PRVHSHPDS------------------------------- HPRLSSGIHGD--------------------------EEDEKPLP-------------AT ------------------------------------------------------------ ---------------------VVNDH-V------------P-----------------SS S------------------RQPVSRGWEALRRSPQRGASLHRKEPIPENP---------- -------------------------------KSA-------------------------- ----------------------------------------------------------GA --------------------------DAHPQGKY-------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------SSLSSKAQDVQQS-TDADTEGHSPKAQ PGSTDRHAFPPRP----------------------------------------------- ---------------------------------------------------PAA------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------RSQH----------------- ------------------------------------------------------------ ---------------------------------------------------HPG-PSVPR RMTPGR--------------------APEQQPPSPVSTSQ-HQP-GPQSRDAGRSPSPPR LALA-PARGP---------------------RPTSQ------------------------ ------------------------------------------------------------ ---------------GRSHFSSD------------------------------------- ---------------------------AYT-----------------------------A SS--------------------RGILPTALQNQ--------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -D---------------------------------------------------------- ----------EVAQG--------------------------------------------- ---------------------------SYDEDSA-------------------------- ---------------EVEAQDVRAPAHAAR------------------------------ --------------------------------------AKD------------------- ------------------------------------------------------------ ----------------------AAASLPKRQQV--------------------------- ------ESPTGAGAGGDDRSQRGH------------------------------------ ------------------------------------------------------------ ------------------------------------------------AGSL-------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------ARPSR---------------------------------- ------------------------------------------------------------ ----------------P------------------------------------------- -----------------------GG-------------------PQSRARVP-------- -------------------------------------------------------SRAAP YSGQKEEGAIQATP--GKSEPPSKRPLSS------------------------------- ----------KSQQSVSAE----------------DE-EEEDAGFFKGGKE-DLLSSSVP KWPSSST-PRGGKDADG------------------------------SLAKDERE----- --------------------------------------------------TAIALAP--- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------RGG------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----SL------------------------------------------------------ -------------------APA-------------------------------------- -------------------KRPLPQP-P-------------------------------- ------------------------------------------------------------ ------------------------------G------------------NS--PRASHLP SLPPP-----------RSA----------------------------ATAS--------- ---------------------------------PVAGTHPWPR----------------- --------------YTTRAPPGH------------------------------------- -----ST-T--------------------------------------------------- ------------------------------PML----------SLRQRMMH--------- ----A----------RFRNPL-----SRQ-------------PA---------------- ------------------------------------------------------------ ---------------------------RPSY------R------Q--------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------GYNGRPNV----------- --EGR---VLPGSNGKPNGQRIINGPQGTKWVVDLDRGLVLNAEGRHLQDSHGNPLRIKL GGDGRTIVDLEGTPVVSPDGLPLFGQGRHGTPLASAQDKPILSLGGKPLVGLE--VIKTT THPP-TT-----TTRP---------TTTTTPLP--------T--TTTQRPT-----T--- --------AT-----TRRT--TTT------------------------------------ ---RR-T-TTRR-------PTTTVR--------TTTR-----------------TT--TT ----------TTPKP-------------TT------------------------------ -PIPTCPPGTLERHDNDGNLIM-SSSGVPECY--------------------------T- ------------------------EEDEFSGLETD--------TAVPTEEAYVIYDE--- ---------------------D--------YE-FE-TSR-------P-----P---T--- -------TTQPS-------------------------------------------TTA-- TTPG-----------VIAEEGA----------------------I--------------- -----SSFPEEEFDLAGRKRFV--------------------------APYVTYLNKDPS APCSLTDALDHFQVDSLDEIIPND--LRRSDLPPQHSPRNITVVAVEGCHSFVIVDWDKA TPGDVVTGYLVYSASYEDFIRNKWSTQASSVTHLPIENLKPNT----------------- -------------RYYFKVQAQNPHGYGPISPSVSFVTESDNPLLVVRPPG--------- ------GEPIWIPFAFKHDPGYTDCHGRQYVKRTWYRKFVGVVLCNSLRYKIFLSDNL-K -DTFYSIGDSWGRGEDHCQFVDSHLDGRTGPQSYVEALPTIQGYYRQYRQEPVSFGNIGF GTPYYYVGWYECGVSIPGKW---------------------------------------- ------------------------------------------------------ >ENSRBIP00000009516 -----------------------------------------M------------------ -------------------------------------RLLTCDFSLTGLQKPQLWSWEGM ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------L-----CRFFI-------------FDSCAVYIVDHPL------- -----------------------KPRHVKLLSTKMGLKVTWDPPKDATSRPV----EHYN ------------------------------------------------------I-AYGK S-----------------------------------------------LK---------- -----------SLKYIKVNAKTYSFLIEDV--------------------------EPGV VYFVLLTAENHS--------GVSRPVYRAESPP--------------------------- -------------------------------------------------------GG--- ---------------------------------EWIEIDGFPIKGPGP------------ ------------------FNETVT------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------EKEVPNKPLRVRVRSS-------------------------------------- -----------------DDRLSVAWKAPRL-SGAKS-------PR-RSRGFLLGYG---- -ESGRKMNY------------VPLTRDERTHEIKKL---ASESV---------------- ---------YVVSLQSMN-----------------SQGRSQPVYRAALTKRKISEE---- ---DELDVPDDISVRVMSSQSVLVSWVDPVLE-KQKKVV--AS-RQYTVRYREKGELARW DYKQIANRRVLIENLIPDTVYEFAVRISQGERDGKWSTSVFQRTPESAPTTAPENLNVWP VNGKPTVVAVSWDALPETEGKVKEYILSYAPALKPFGAKSLTYRGDTTSALVDGLQPGER YLFKIRAANRRGLGPHSKAFIVAVPT-----------T-S--KADVQQ--NTEDNGKPEK PE----------------------------------------------LSSPSPRAPA-- -------SSQHPS-V--------------------------------------------- --------PASPQGRNAKDLLLDLKNKILANGGAPRKPQLRAKKAEEL---DLQS----T EVTG-------KEELGSREDSPMLPSD-------------TQD----------------- -----------QKRTLRQ--PSRHGHSVVAPGRTAVRARIPALPRREGVDK-PGFSPASH --------PR---------------------------------------PGAPPSASA-S PAHHAATQ---------------------------------------------------- -----------------------------GTSHR--------------------P----- ------------------------------------------------------------ ------------------P-----------LPASFHDN---------------------- ----------------------DLVDSDEDERAVGSPHPKG------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------------------AFAQ PRPALSPSRQSPSSVLRDRSSVHPGAKPASPA-------------------RRTP----- --------H-------------------------SGAAEEDSNASVP------------- ------PSR---------------------------LSPPHGGSSRLLPTQPHRGP---- -------PLSRGGKDGEDASATNSS---------------VPSWSTVS------------ -----------SSVSSR------------------------------------------- ------------------------------------------------------------ LSSRTQVSV------------------------------------------GAEASDGEG DGNGDREDGGRQAEATAQTLRA---------R---------------------------- ------------PASGHFHLLRHKPFAANGRSPSRFGIGRGPRLQPSSS---PQS---TV PSRAH------------------------------------------------------- --------------------PRVHSHPDS------------------------------- HSRLSSGIHGD--------------------------EEDEKPLP-------------AT ------------------------------------------------------------ ---------------------IVNDH-V------------P-----------------SS S------------------RQPISRGWEAIRRSPQRGASLHRKEPIPENP---------- -------------------------------KSA-------------------------- ----------------------------------------------------------GA --------------------------DAHPEGKY-------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------SSLSSKAQDVQQS-TDADTEGHSPKAQ PGSTDRHASPPRP----------------------------------------------- ---------------------------------------------------PAA------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------RSQH----------------- ------------------------------------------------------------ ---------------------------------------------------HPG-PSVPR RMTPGR--------------------APEQQPPSPVSTSQ-HQP-GPQSRDAGQSPSQPR LALA-PARGP---------------------RPTSQ------------------------ ------------------------------------------------------------ ---------------GRSHFSSD------------------------------------- ---------------------------PYT-----------------------------A SS--------------------RGILPTALQNQ--------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -D---------------------------------------------------------- ----------EDAQG--------------------------------------------- ---------------------------IYDKDST-------------------------- ---------------EVEAQDVRAPAHAAR------------------------------ --------------------------------------AKD------------------- ------------------------------------------------------------ ----------------------AAASLPKHQQV--------------------------- ------ESPTGAGAGGDDRSQRGH------------------------------------ ------------------------------------------------------------ ------------------------------------------------AGSL-------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------ARPSR---------------------------------- ------------------------------------------------------------ ----------------P------------------------------------------- -----------------------GG-------------------PQSRARVP-------- -------------------------------------------------------SRAA- ------------TP--GKSEPPSKRPLSS------------------------------- ----------KSQQSVSAE----------------DE-EEEDAGFFKGGKE-DLLSSSVP KWPSSST-PRGGKDADG------------------------------SLAKDERE----- --------------------------------------------------SAIALAP--- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------RGG------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----SL------------------------------------------------------ -------------------APA-------------------------------------- -------------------KRPLPQP-P-------------------------------- ------------------------------------------------------------ ------------------------------G------------------SS--PRASHLP SLPPP-----------RSA----------------------------ATAS--------- ---------------------------------PVAGTHPWPR----------------- --------------YTTRAPPGH------------------------------------- -----ST-T--------------------------------------------------- ------------------------------PML----------SLRQRMMH--------- ----A----------RFRNPL-----SRQ-------------PA---------------- ------------------------------------------------------------ ---------------------------RPPY------R------Q--------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------GYNGRPNV----------- --EGK---VLPGSNGKPNGQRIINGPQGTKWVVDLDRGLVLNAEGRYLQDSHGNPLRIKL GGDGRTIVDLEGTPVVSPDGLPLFGQGRHGTPLASAQDKPILSLGGKPLVGLE--VIKTT THPP-TT-----TTRP---------TTTTTPLP--------T--TTTQRPT-----T--- --------AT-----TRRT--TTT------------------------------------ ---RR-T-TTRR-------PTTTVG--------TTTR-----------------TT--TT ----------TTAKP-------------TT------------------------------ -PIPTCPPGTLERRDNDGNLIM-SSNGIPECY--------------------------T- ------------------------EEDEFSGLETD--------TAVPTEEAYVIYDE--- ---------------------D--------YE-FE-TSR-------P-----P---T--- -------TTQPS-------------------------------------------TTA-- TTPG-----------VIAEEGA----------------------I--------------- -----SSFPEEQFDLAGRKRFV--------------------------APYVTYLNKDPS APCSLTDALDHFQVDSLDEIIPND--LRKSDLPPQHSPRNITVVAVEGCHSFVIVDWDKA TPGDVVTGYLVYSASYEDFIRNKWSTQASSVTHLPIENLKPNT----------------- -------------RYYFKVQAQNPHGYGPVSPSVSFVTESDNPLLVVRPPG--------- ------GEPIWIPFAFKHDPGYTDCHGRQYVKRTWYRKFVGVVLCNSLRYKIFLSDNL-K -DTFYSIGDSWGRGEDHCQFVDSHLDGRTGPQSYVEALPTIQGYYRQYRQEPVSFGNIGF GTPYYYVGWYECGVSIPGKW---------------------------------------- ------------------------------------------------------ >ENSRROP00000012200 -----------------------------------------M------------------ -------------------------------------RLLTCDFSLTGLQKPQLWSWEGM IKKIH------------------------------------------------------- ------------------------------------------------------------ --------------------------------------------------F--------- ---------------------------------------PNL------------------ --------------LF---------------------------CAVYIVDHPL------- -----------------------KPRHVKLLSTKMGLKVTWDPPKDATSRPV----EHYN ------------------------------------------------------I-AYGK S-----------------------------------------------LK---------- -----------SLKYIKVNAKTYSFLIEDV--------------------------EPGV VYFVLLTAENHS--------GVSRPVYRAESPP--------------------------- -------------------------------------------------------GG--- ---------------------------------EWIEIDGFPIKGPGP------------ ------------------FNETVT------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------EKEVPNKPLRVRVRSS-------------------------------------- -----------------DDRLSVAWKAPRL-SGAKS-------PR-RSRGFLLGYG---- -ESGRKMNY------------VPLTRDERTHEIKKL---ASESV---------------- ---------YVVSLQSMN-----------------SQGRSQPVYRAALTKRKISEE---- ---DELDVPDDISVRVMSSQSVLVSWVDPVLE-KQKKVV--AS-RQYTVRYREKGELARW DYKQIANRRVLIENLIPDTVYEFAVRISQGERDGKWSTSVFQRTPESAPTTAPENLNVWP VNGKPTVVAVSWDALPETEGKVKEYILSYAPALKPFGAKSLTYRGDTTSALVDGLQPGER YLFKIRAANRRGLGPHSKAFIVAVPT-----------T-S--KADVQQ--NTEDNGKPEK PE----------------------------------------------LSSPSPRAPA-- -------SSQHPS-V--------------------------------------------- --------PASPQGRNAKDLLLDLKNKILANGGAPRKPQLRAKKAEEL---DLQS----T EVTG-------KEELGSREDSPMLPSD-------------TQD----------------- -----------QKRTLRQ--PSRHGHSVVAPGRTAVRARIPALPRREGVDK-PDFSPASH --------PR---------------------------------------PGAPPSASA-S PAHHAATQ---------------------------------------------------- -----------------------------GTSHR--------------------P----- ------------------------------------------------------------ ------------------P-----------LPASFHDN---------------------- ----------------------DLVDSDEDERAVGSPHPKG------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------------------AFAQ PRPALSPSRQSPSSVLRDRSSVHPGAKPASPA-------------------RRTP----- --------H-------------------------SGAAEEDSNASVP------------- ------PSR---------------------------LSPPHGGSSRLLPTQPHPGP---- -------PLSRGGKDGEDASATNSN---------------VPSWSTVS------------ -----------SSVSSR------------------------------------------- ------------------------------------------------------------ LSSRTQVSV------------------------------------------GAEASDGEG DGNGDREDGGRQAEATAQTLRA---------R---------------------------- ------------PASGHFHLLRHKPFAANGRSPSRFGFGRGPRLQPSSS---PQS---TV PPRAH------------------------------------------------------- --------------------PRVHSHPDS------------------------------- HSRLSSGIHGD--------------------------EEDEKPLP-------------AT ------------------------------------------------------------ ---------------------IVNDH-V------------P-----------------SS S------------------RQPISRGWEAIRRSPQRGASLHRKEPIPENP---------- -------------------------------KSA-------------------------- ----------------------------------------------------------GA --------------------------DAHPEGKY-------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------SSLSSKAQDVQQS-TDADTEGHSPKAQ PGSTDRHASPPRP----------------------------------------------- ---------------------------------------------------PAA------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------RSQH----------------- ------------------------------------------------------------ ---------------------------------------------------HPG-PSVPR RMTPGR--------------------APEQQPPSPVSTSQ-HQP-GPQSRDARQSPSQPR LALA-PARGP---------------------RPTSQ------------------------ ------------------------------------------------------------ ---------------GRSHFSSD------------------------------------- ---------------------------PYT-----------------------------A SS--------------------RGILPTALQNQ--------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -D---------------------------------------------------------- ----------EDAQG--------------------------------------------- ---------------------------VYDKDST-------------------------- ---------------EVEAQDVRAPAHAAR------------------------------ --------------------------------------AKD------------------- ------------------------------------------------------------ ----------------------AAASLPKHQQV--------------------------- ------ESPTGAGAGGDDRSQRGH------------------------------------ ------------------------------------------------------------ ------------------------------------------------AGSL-------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------ARPSR---------------------------------- ------------------------------------------------------------ ----------------P------------------------------------------- -----------------------GG-------------------PQSRARVP-------- -------------------------------------------------------SRAA- ------------TP--GKSEPPSKRPLSS------------------------------- ----------KSQQSVSAE----------------DE-EEEDAGFFKGGKE-DLLSSSVP KWPSSST-PRGGKDADG------------------------------SLAKDERE----- --------------------------------------------------SAIALAP--- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------RGG------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----SL------------------------------------------------------ -------------------APA-------------------------------------- -------------------KRPLPQP-P-------------------------------- ------------------------------------------------------------ ------------------------------G------------------SS--PRASHLP SLPPP-----------RSA----------------------------ATAS--------- ---------------------------------PVAGTHPWPR----------------- --------------YTTRAPPGH------------------------------------- -----ST-T--------------------------------------------------- ------------------------------PML----------SLRQRMMH--------- ----A----------RFRNPL-----SRQ-------------PA---------------- ------------------------------------------------------------ ---------------------------RPPY------R------Q--------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------GYNGRPNV----------- --EGK---VLPGSNGKPNGQRIINGPQGTKWVVDLDRGLVLNAEGRYLQDSHGNPLRIKL GGDGRTIVDLEGTPVVSPDGLPLFGQGRHGTPLASAQDKPILSLGGKPLVGLE--VIKTT THPP-TT-----TTRP---------TTTTTPLP--------T--TTTQRPT-----T--- --------AT-----TRRT--TTT------------------------------------ ---RR-T-TTRR-------PTTTVR--------TTTR-----------------TT--TT ----------TTAKP-------------TT------------------------------ -PIPTCPPGTLERRDNDGNLIM-SSNGIPECY--------------------------T- ------------------------EEDEFSGLETD--------TAVPTEEAYVIYDE--- ---------------------D--------YE-FE-TSR-------P-----P---T--- -------TTQPS-------------------------------------------TTA-- TTPG-----------VIAEEGA----------------------I--------------- -----SSFPEEQFDLAGRKRFV--------------------------APYVTYLNKDPS APCSLTDALDHFQVDSLDEIIPND--LRKSDLPPQHSPRNITVVAVEGCHSFVIVDWDKA TPGDVVTGYLVYSASYEDFIRNKWSTQASSVTHLPIENLKPNT----------------- -------------RYYFKVQAQNPHGYGPISPSVSFVTESDNPLLVVRPPG--------- ------GEPIWIPFAFKHDPGYTDCHGRQYVKRTWYRKFVGVVLCNSLRYKIFLSDNL-K -DTFYSIGDSWGRGEDHCQFVDSHLDGRTGPQSYVEALPTIQGYYRQYRQEPVSFGNIGF GTPYYYVGWYECGVSIPGKW---------------------------------------- ------------------------------------------------------ >ENSCANP00000027672 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------------DHPL------- -----------------------KPRHVKLLSTKMGLKVTWDPPKDATSRPV----EHYN ------------------------------------------------------I-AYGK S-----------------------------------------------LK---------- -----------SLKYIKVNAETYSFLIEDV--------------------------EPGV VYFVLLTAENHS--------GVSRPVYRAESPP--------------------------- -------------------------------------------------------GG--- ---------------------------------EWIEIDGFPIKGPGP------------ ------------------FNETVT------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------EKEVPNKPLRVRVRSS-------------------------------------- -----------------DDRLSVAWKAPRL-SGAKS-------PR-KSRGFLLGYG---- -ESGRKMNY------------VPLTRDERTHEIKKL---ASESV---------------- ---------YVVSLQSMN-----------------SQGRSQPVYRAALTKRKISEE---- ---DELDVPDDISVRVMSSQSVLVSWVDPVLE-KQKKVV--AS-RQYTVRYREKGELARW DYKQIANRRVLIENLIPDTVYEFAVRISQGERDGKWSTSVFQRTPESAPTTAPENLNVWP VNGKPTVVAVSWDALPETEGKVKEYILSYAPALKPFGAKSLTYRGDTTSALVDGLQPGER YLFKIRAANRRGLGPHSKAFIVAVPT-----------T-S--KADVQQ--NTEDNGKPEK PE----------------------------------------------LSSPSPRAPA-- -------SSQHPS-V--------------------------------------------- --------PASPQGRNAKDLLLDLKNKILANGGAPRKPQLRAKKAEEL---DLQS----T EVTG-------KEELGSREDSPMLPSD-------------TQD----------------- -----------QKRTLRQ--PSRHGHSVVAPGRTAVRARMPALPRREGVDK-PGFSPAFH --------PR---------------------------------------PGAPPSASA-S PAHHAATQ---------------------------------------------------- -----------------------------GTSHR--------------------P----- ------------------------------------------------------------ ------------------P-----------LPASFHDN---------------------- ----------------------DLVDSDEDERAVGSPHPKG------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------------------AFAQ PQPALSPSRQSPSSVLRDRSSVHPGAKPASPA-------------------RRTP----- --------H-------------------------SGAAEEDSNASVP------------- ------PSR---------------------------LSPPHGGSSRLLPTQPHRGP---- -------PLSRGGKDGEDAPATNSN---------------VPSRSTMS------------ -----------SSVSSR------------------------------------------- ------------------------------------------------------------ LSSRTQVSA------------------------------------------GAEASDGEG DRNGDREDGGRQAEATAQTLRA---------R---------------------------- ------------PASGHFHLLRHKPFAANGRSPSRFGIGRGPRLQPSSS---PQS---TV PSRAH------------------------------------------------------- --------------------PRVHSHPDS------------------------------- HSRLSSGIHGD--------------------------EEDEKPLP-------------AT ------------------------------------------------------------ ---------------------VVNDH-V------------P-----------------SS S------------------RQPISRGWEAVRRSPQRGASLHRKEPIPENP---------- -------------------------------KSA-------------------------- ----------------------------------------------------------GA --------------------------DAHPQGKY-------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------SSLSSKAQDVQQS-TDADTEGHSPKAQ PGSTDRHASPPRP----------------------------------------------- ---------------------------------------------------PAA------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------RSQH----------------- ------------------------------------------------------------ ---------------------------------------------------HPG-PSVPR RMTPGR--------------------APEQQPPSAVSTSQ-HQP-GPQSRDAGQSPSQPR LALA-PARGP---------------------RPTSQ------------------------ ------------------------------------------------------------ ---------------GRSHFSSD------------------------------------- ---------------------------PYM-----------------------------A SS--------------------RGILPTALQNR--------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -D---------------------------------------------------------- ----------EDAQG--------------------------------------------- ---------------------------GYDKDSA-------------------------- ---------------EVEAQDVRAPAHAAR------------------------------ --------------------------------------AKD------------------- ------------------------------------------------------------ ----------------------AAASLPKHQQV--------------------------- ------ESPTGAGAGGDDRSQRGH------------------------------------ ------------------------------------------------------------ ------------------------------------------------AGSL-------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------ARPSR---------------------------------- ------------------------------------------------------------ ----------------P------------------------------------------- -----------------------GG-------------------PQSRARVP-------- -------------------------------------------------------SRAA- -------------P--GKSEPPSKRPLSS------------------------------- ----------KSQQSVSAE----------------DE-EEEDAGFFKGRKE-DLLSSSVP KWPSSST-PRGGKDAEG------------------------------SLAKDERE----- --------------------------------------------------SAIALAP--- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------RGG------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----SL------------------------------------------------------ -------------------APA-------------------------------------- -------------------KRPLPQP-P-------------------------------- ------------------------------------------------------------ ------------------------------G------------------SS--PRASHLP SLPPP-----------RSA----------------------------ATAS--------- ---------------------------------PVAGTHPWPR----------------- --------------YTTRAPPGH------------------------------------- -----ST-T--------------------------------------------------- ------------------------------PML----------SLRQRMMH--------- ----A----------RFRNPL-----SRQ-------------PA---------------- ------------------------------------------------------------ ---------------------------RPPY------R------Q--------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------GYNGRPNV----------- --EGK---VLPGSNGKPNGQRIINGPQGTKWVVDLDRGLVLNAEGRYLQDSHGNPLRIKL GGDGRTIVDLEGTPVVSPDGLPLFGQGRHGTPLASAQDKPILSLGGKPLVGLE--VIKTT THPP-TT-----TTRP---------TTTTTPLP--------T--TTTQRPT-----T--- --------AT-----TRRT--TTT------------------------------------ ---RR-T-TTRR-------PTTTVR--------TTTR-----------------TT--TT ----------TTPKP-------------TT------------------------------ -PIPTCPPGTLERRDNDGNLIM-NSNGIPECY--------------------------T- ------------------------EEDEFSGLETD--------TAVPTEEAYVIYDE--- ---------------------D--------YE-FE-TSR-------P-----P---T--- -------TTQPS-------------------------------------------TTA-- TTPG-----------IIAEEGA----------------------I--------------- -----SSFPEEEFDLAGRKRFV--------------------------APYVTYLNKDPS APCSLTDALDHFQVDSLDEIIPND--LRKSDLPPQHSPRNITVVAVEGCHSFVIVDWDKA APGDVVTGYLVYSASYEDFIRNKWSTQASSVTHLPIENLKPNT----------------- -------------RYYFKVQAQNPHGYGPISPSVSFVTESDNPLLVVRPPG--------- ------GEPIWIPFAFKHDPGYTDCHGRQYVKRTWYRKFVGVVLCNSLRYKIFLSDNL-K -DTFYSIGDSWGRGEDHCQFVDSHLDGRTGPQSYVEALPTIQGYYRQYRQEPVSFGNIGF GTPYYYVGWYECGVSIPGKW---------------------------------------- ------------------------------------------------------ >ENSPTEP00000041522 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------------MA-------- ---PEAGATLRAPRR-LPWAA-LLLLAVLLPVASSAG-AP-------------------- ------------------------------------------------VDHPL------- -----------------------KPRHVKLLSTKMGLKVTWDPPKDATSRPV----EHYN ------------------------------------------------------I-AYGK S-----------------------------------------------LK---------- -----------SLKYIKVNAETYSFLIEDV--------------------------EPGV VYFVLLTAENHS--------GVSRPVYRAESPP--------------------------- -------------------------------------------------------GG--- ---------------------------------EWIEIDGFPIKGPGS------------ ------------------FNETVT------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------EKEVPNKPLRVRVRSS-------------------------------------- -----------------DDRLSVAWKAPRL-SGAKS-------PR-RSRGFLLGYG---- -ESGRKMNY------------VPLTRDERTHEIKKL---ASESV---------------- ---------YVVSLQSMN-----------------SQGRSQPVYRAALTKRKISEE---- ---DELDVPDDISVRVMSSQSVLVSWVDPVLE-KQKKVV--AS-RQYTVRYREKGELARW DYKQIANRRVLIENLIPDTVYEFAVRISQGERDGKWSTSVFQRTPESAPTTAPENLNVWP VNGKPTVVAVSWDALPETEGKVKEYILSYAPALKPFGAKSLTYRGDTTSALVDGLQPGER YLFKIRAANRRGLGPHSKAFIVAVPT-----------T-S--KADVQQ--NTEDNGKPEK PE----------------------------------------------LSSPSPRAPA-- -------SSQHPS-V--------------------------------------------- --------PASPQGRNAKDLLLDLKNKILANGGVPRKPQLRAKKAEEL---DLQS----T EVTG-------KEELGSREDSPMLPSD-------------TQD----------------- -----------QKRTLRQ--PSRHGHSVVAPGRTAVRARMPALPRREGVDK-PGFSPASH --------PR---------------------------------------PRATPSASA-S PAHQAATQ---------------------------------------------------- -----------------------------GTSHR--------------------P----- ------------------------------------------------------------ ------------------P-----------LPASFHDN---------------------- ----------------------DLVDSDEDERAVGSPHPKG------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------------------AFAQ PRPALSPSRQSPSSVLRDRSSVHPGAKPASPA-------------------RRTP----- --------H-------------------------SGTAEEDSNASVP------------- ------PSR---------------------------LSPPHGGSSRLLPTQPHRGP---- -------PLSRGGKDGEDAPATNSN---------------VPSRSTMS------------ -----------SAVSSR------------------------------------------- ------------------------------------------------------------ LSSRTQVSA------------------------------------------GAEASDGEG DGNGDREDGWRQAEATAQTLRA---------R---------------------------- ------------PASGHLHLLRHKPFAANGRSPSRFGIGRGPRLQPSSS---PQS---TV PSRAH------------------------------------------------------- --------------------PRVHSHPDS------------------------------- HSRLSSGIHED--------------------------EEDEKPLP-------------AT ------------------------------------------------------------ ---------------------VVNDH-V------------P-----------------SS S------------------RQPISRGWEAVRRSPQRGASLHRKEPIPENP---------- -------------------------------KSA-------------------------- ----------------------------------------------------------GA --------------------------DAHPQGKY-------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------SSLSSKAQDVQQS-TDADTEGHSPKAQ PGSTDRHVSPPRP----------------------------------------------- ---------------------------------------------------PAA------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------RSQH----------------- ------------------------------------------------------------ ---------------------------------------------------HPG-PSVPR RMTPGR--------------------APEQQPPSPVSTSQ-HQL-GPQSRDAGQSLSQPR LALA-PARGP---------------------RPTSQ------------------------ ------------------------------------------------------------ ---------------GRSYFSSD------------------------------------- ---------------------------PYT-----------------------------A SS--------------------RGILPTALQNQ--------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -D---------------------------------------------------------- ----------EDAQG--------------------------------------------- ---------------------------GYDADST-------------------------- ---------------EVEAQDVRAPAHAAR------------------------------ --------------------------------------AKD------------------- ------------------------------------------------------------ ----------------------AAVSLPKHQQV--------------------------- ------ESPTGAGAGGDDRSQRGH------------------------------------ ------------------------------------------------------------ ------------------------------------------------AGSL-------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------ARPSR---------------------------------- ------------------------------------------------------------ ----------------P------------------------------------------- -----------------------SG-------------------PQSRARVP-------- -------------------------------------------------------SRAA- -------------PYSGKSEPPSKRPLSS------------------------------- ----------KSQQSVSAE----------------DE-EEEDAGFFKGGKE-DLLSSSVP KWPSSST-PRGGKDADG------------------------------SLAKDERE----- --------------------------------------------------SAIALAP--- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------RGG------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----SL------------------------------------------------------ -------------------APV-------------------------------------- -------------------KRPLPQP-A-------------------------------- ------------------------------------------------------------ ------------------------------G------------------SS--PRASHLP SLPPP-----------RSA----------------------------ATAS--------- ---------------------------------PVAGTHPWPR----------------- --------------YTTRAPPGH------------------------------------- -----ST-T--------------------------------------------------- ------------------------------PML----------SLRQRMMH--------- ----A----------RFRNPL-----SRQ-------------PA---------------- ------------------------------------------------------------ ---------------------------RPPY------R------Q--------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------GYNGRPNV----------- --EGK---VLPGSNGKPNGQRIINGPQGTKWVVDLDRGLVLNAEGRYLQDSHGNPLRIKL GGDGRTIVDLEGTPVVSPDGLPLFGQGRHGTPLASAQDKPILSLGGKPLVGLE--VIKTT THPP-TT-----TTRP---------TTTTTPLP--------T--TTTQRPT-----T--- --------AT-----TRRT--TTT------------------------------------ ---RR-T-TTRR-------PTTTVR--------TTTR-----------------TT--TT ----------TTPKP-------------TT------------------------------ -PIPTCPPGTLERRDNDGNLIM-SSNGIPECY--------------------------T- ------------------------EEDEFSGLETD--------TAVPTEEAYVIYDE--- ---------------------D--------YE-FE-TSR-------P-----P---T--- -------TTQPS-------------------------------------------TTA-- TTPG-----------VIAEEGA----------------------I--------------- -----SSFPEEEFDLAGRKRFV--------------------------APYVTYLNKDPS APCSLTDALDHFQVDSLDEIIPND--LRKSDLPPQHSPRNITVVAVEGCHSFVIVDWDKA APGDVVTGYLVYSASYEDFIRNKWSTQASSVTHLPIENLKPNT----------------- -------------RYYFKVQAQNPHGYGPVSPSVSFVTESDNPLLVVRPPG--------- ------GEPIWIPFAFKHDPGYTDCHGRQYVKRTWYRKFVGVVLCNSLRYKIFLSDNL-K -DTFYSIGDSWGRGEDHCQFVDSHLDGRTGPQSYVEALPTIQGYYRQYRQEPVSFGNIGF GTPYYYVGWYECGVSIPGKW---------------------------------------- ------------------------------------------------------ >ENSPTRP00000032009 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------------MA-------- ---PEAGATLRAPRR-LSWAA-LLLLAALLPVASSAG-AP-------------------- ------------------------------------------------VDHPL------- -----------------------KPRHVKLLSTKMGLKVTWDPPKDATSRPV----EHYN ------------------------------------------------------I-AYGK S-----------------------------------------------LK---------- -----------SLKYIKVNAETYSFLIEDV--------------------------EPGV VYFVLLTAENHS--------GVSRPVYRAESPP--------------------------- -------------------------------------------------------GG--- ---------------------------------EWIEIDGFPIKGPGP------------ ------------------FNETVT------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------EKEVPNKPLRVRVRSS-------------------------------------- -----------------DDRLSVAWKAPRL-SGAKS-------PR-RSRGFLLGYG---- -ESGRKMNY------------VPLTRDERTHEIKKL---ASESV---------------- ---------YVVSLQSMN-----------------SQGRSQPVYRAALTKRKISEE---- ---DELDVPDDISVRVMSSQSVLVSWVDPVLE-KQKKVV--AS-RQYTVRYREKGELARW DYKQIANRRVLIENLIPDTVYEFAVRISQGERDGKWSTSVFQRTPESAPTTAPENLNVWP VNGKPTVVAASWDALPETEGKVKEYILSYAPALKPFGAKSLTYPGDTTSALVDGLQPGER YLFKIRAANRRGLGPHSKAFIVAMPT-----------T-R--KADVQQ--NTEDNGKPEK PE----------------------------------------------PSSPSPRAPA-- -------SSQHPS-V--------------------------------------------- --------PASPQGRNAKDLLLDLKNKILANGGAPRKPQLRAKKAEEL---DLQS----T EITG-------EEELGSREDSPMSPSD-------------TQD----------------- -----------QKQTLRP--PSRHGHSVVAPGRTAVRARMPALPRREGVDK-PGFSLATQ --------PR---------------------------------------PGAPPSASA-S PAHHASTQ---------------------------------------------------- -----------------------------GTSHR--------------------P----- ------------------------------------------------------------ ------------------S-----------LPASLNDN---------------------- ----------------------DLVDSDEDELAVGSLHPKG------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------------------AFAQ PRPALSPSRQSPSSVLRDRSSVHPGAKPASPA-------------------RRTP----- --------H-------------------------SGAAEEDSSASAP------------- ------PSR---------------------------LSPPHGGSSRLPPTQPHLGS---- -------PLSRGGKDGEDAPATNSN---------------APSRSTMS------------ -----------SSVSSR------------------------------------------- ------------------------------------------------------------ LSSRTQV------------------------------------------------SDGES HGDGDREDGGRQAEATAQTLRA---------R---------------------------- ------------PASGHFHLLRHKPFAANGRSPSRFSIGRGPRLQPSSS---PQS---TV PSRAH------------------------------------------------------- --------------------PRVPSHSNS------------------------------- HPKLSSGIHRD--------------------------EEDEKPLP-------------AT ------------------------------------------------------------ ---------------------VVNDH-V------------P-----------------SS S------------------RQPISRGWEALRRSPQRGASLHRKEPIPENP---------- -------------------------------KST-------------------------- ----------------------------------------------------------GA --------------------------DTHPQGKY-------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------SSLASKAQDVQQS-TDADTEGHSPKAQ PGSTDRHASPARP----------------------------------------------- ---------------------------------------------------PAA------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------RSQQ----------------- ------------------------------------------------------------ ---------------------------------------------------H---PSVPR RMTPGR--------------------APEQQPPPPVATSQ-HHP-GPQSRDEGRSHSQPR LSLT-QAGRP---------------------RPTSQ------------------------ ------------------------------------------------------------ ---------------GRSHSSSD------------------------------------- ---------------------------PYT-----------------------------A SS--------------------RGMLPTALQNQ--------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -D---------------------------------------------------------- ----------EDAQG--------------------------------------------- ---------------------------SYNDDST-------------------------- ---------------EVEAQDVRAPAHAAR------------------------------ --------------------------------------AKE------------------- ------------------------------------------------------------ ----------------------AAASLPKHQQV--------------------------- ------ESPTGAGAGGDHRSQRGH------------------------------------ ------------------------------------------------------------ ------------------------------------------------AGSP-------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------ARPSR---------------------------------- ------------------------------------------------------------ ----------------P------------------------------------------- -----------------------GG-------------------PQSRARVP-------- -------------------------------------------------------SRAA- -------------P--GKSESPSKRPLSS------------------------------- ----------KSQQSVSAE----------------DE-EEEDAGFFKGGKE-DLLSSSVP KWPSSST-PRGGKDADG------------------------------SLAKEERE----- --------------------------------------------------PAIALAP--- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------RGG------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----SL------------------------------------------------------ -------------------APV-------------------------------------- -------------------KQPLPPP-P-------------------------------- ------------------------------------------------------------ ------------------------------G------------------SS--PRASHVP SRPPP-----------RSA----------------------------ATVS--------- ---------------------------------PVAGTHPWPR----------------- --------------YTTRAPPGH------------------------------------- ----SST-T--------------------------------------------------- ------------------------------PML----------SLRQRMMH--------- ----A----------RFRNPL-----SRQ-------------PA---------------- ------------------------------------------------------------ ---------------------------RPSY------R------Q--------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------GYNGRPNV----------- --EGK---VLPGSNGKPNGQRIINGPQGTKWVVDLDRGLVLNAEGRYLQDSYGNPLRIKL GGDGRTIVDLEGTPVVSPDGLPLFGQGRHGTPLANAQDKPILSLGGKPLVGLE--VIKKT THPP-TT-----TTQP---------TTTTTPLP--------T--TTTPRPT-----T--- --------AT-----TRRM--TTT------------------------------------ ---RR-T-TTRR-------PTTTVR--------TTTR-----------------TT--TT ----------TTPKP-------------TT------------------------------ -PIPTCPPGTLERHDDDGNLIM-SSNGIPECY--------------------------A- ------------------------EEDEFSGLETD--------TAVPTEEAYVIYDE--- ---------------------D--------YE-FE-TSR-------P-----P---T--- -------TTEPS-------------------------------------------TTA-- TTPR-----------VIPEEGA----------------------I--------------- -----SSFPEEEFDLAGRKRFV--------------------------APYVTYLNKDPS APCSLTDALDHFQVDSLDEIIPND--LKKSDLPPQHAPRNITVVAVEGCHSFVIVDWDKA TPGDVVTGYLVYSASYEDFIRNKWSTQASSVTHLPIENLKPNT----------------- -------------RYYFKVQAQNPHGYGPISPSVSFVTESDNPLLVVRPPG--------- ------GEPIWIPFAFKHDPSYTDCHGRQYVKRTWYRKFVGVVLCNSLRYKIYLSDNL-K -DTFYSIGDSWGRGEDHCQFVDSHLDGRTGPQSYVEALPTIQGYYRQYRQEPVRFGNIGF GTPYYYVGWYECGVSIPGKW---------------------------------------- ------------------------------------------------------ >ENSP00000297267 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------------MA-------- ---PEAGATLRAPRR-LSWAA-LLLLAALLPVASSAA-AS-------------------- ------------------------------------------------VDHPL------- -----------------------KPRHVKLLSTKMGLKVTWDPPKDATSRPV----EHYN ------------------------------------------------------I-AYGK S-----------------------------------------------LK---------- -----------SLKYIKVNAETYSFLIEDV--------------------------EPGV VYFVLLTAENHS--------GVSRPVYRAESPP--------------------------- -------------------------------------------------------GG--- ---------------------------------EWIEIDGFPIKGPGP------------ ------------------FNETVT------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------EKEVPNKPLRVRVRSS-------------------------------------- -----------------DDRLSVAWKAPRL-SGAKS-------PR-RSRGFLLGYG---- -ESGRKMNY------------VPLTRDERTHEIKKL---ASESV---------------- ---------YVVSLQSMN-----------------SQGRSQPVYRAALTKRKISEE---- ---DELDVPDDISVRVMSSQSVLVSWVDPVLE-KQKKVV--AS-RQYTVRYREKGELARW DYKQIANRRVLIENLIPDTVYEFAVRISQGERDGKWSTSVFQRTPESAPTTAPENLNVWP VNGKPTVVAASWDALPETEGKVKEYILSYAPALKPFGAKSLTYPGDTTSALVDGLQPGER YLFKIRATNRRGLGPHSKAFIVAMPT-----------T-S--KADVEQ--NTEDNGKPEK PE----------------------------------------------PSSPSPRAPA-- -------SSQHPS-V--------------------------------------------- --------PASPQGRNAKDLLLDLKNKILANGGAPRKPQLRAKKAEEL---DLQS----T EITG-------EEELGSREDSPMSPSD-------------TQD----------------- -----------QKRTLRP--PSRHGHSVVAPGRTAVRARMPALPRREGVDK-PGFSLATQ --------PR---------------------------------------PGAPPSASA-S PAHHASTQ---------------------------------------------------- -----------------------------GTSHR--------------------P----- ------------------------------------------------------------ ------------------S-----------LPASLNDN---------------------- ----------------------DLVDSDEDERAVGSLHPKG------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------------------AFAQ PRPALSPSRQSPSSVLRDRSSVHPGAKPASPA-------------------RRTP----- --------H-------------------------SGAAEEDSSASAP------------- ------PSR---------------------------LSPPHGGSSRLLPTQPHLSS---- -------PLSKGGKDGEDAPATNSN---------------APSRSTMS------------ -----------SSVSSH------------------------------------------- ------------------------------------------------------------ LSSRTQVSE------------------------------------------GAEASDGES HGDGDREDGGRQAEATAQTLRA---------R---------------------------- ------------PASGHFHLLRHKPFAANGRSPSRFSIGRGPRLQPSSS---PQS---TV PSRAH------------------------------------------------------- --------------------PRVPSHSDS------------------------------- HPKLSSGIHGD--------------------------EEDEKPLP-------------AT ------------------------------------------------------------ ---------------------VVNDH-V------------P-----------------SS S------------------RQPISRGWEDLRRSPQRGASLHRKEPIPENP---------- -------------------------------KST-------------------------- ----------------------------------------------------------GA --------------------------DTHPQGKY-------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------SSLASKAQDVQQS-TDADTEGHSPKAQ PGSTDRHASPARP----------------------------------------------- ---------------------------------------------------PAA------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------RSQQ----------------- ------------------------------------------------------------ ---------------------------------------------------H---PSVPR RMTPGR--------------------APQQQPPPPVATSQ-HHP-GPQSRDAGRSPSQPR LSLT-QAGRP---------------------RPTSQ------------------------ ------------------------------------------------------------ ---------------GRSHSSSD------------------------------------- ---------------------------PYT-----------------------------A SS--------------------RGMLPTALQNQ--------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -D---------------------------------------------------------- ----------EDAQG--------------------------------------------- ---------------------------SYDDDST-------------------------- ---------------EVEAQDVRAPAHAAR------------------------------ --------------------------------------AKE------------------- ------------------------------------------------------------ ----------------------AAASLPKHQQV--------------------------- ------ESPTGAGAGGDHRSQRGH------------------------------------ ------------------------------------------------------------ ------------------------------------------------AASP-------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------ARPSR---------------------------------- ------------------------------------------------------------ ----------------P------------------------------------------- -----------------------GG-------------------PQSRARVP-------- -------------------------------------------------------SRAA- -------------P--GKSEPPSKRPLSS------------------------------- ----------KSQQSVSAE----------------DD-EEEDAGFFKGGKE-DLLSSSVP KWPSSST-PRGGKDADG------------------------------SLAKEERE----- --------------------------------------------------PAIALAP--- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------RGG------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----SL------------------------------------------------------ -------------------APV-------------------------------------- -------------------KRPLPPP-P-------------------------------- ------------------------------------------------------------ ------------------------------G------------------SS--PRASHVP SRLPP-----------RSA----------------------------ATVS--------- ---------------------------------PVAGTHPWPQ----------------- --------------YTTRAPPGH------------------------------------- ----FST-T--------------------------------------------------- ------------------------------PML----------SLRQRMMH--------- ----A----------RFRNPL-----SRQ-------------PA---------------- ------------------------------------------------------------ ---------------------------RPSY------R------Q--------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------GYNGRPNV----------- --EGK---VLPGSNGKPNGQRIINGPQGTKWVVDLDRGLVLNAEGRYLQDSHGNPLRIKL GGDGRTIVDLEGTPVVSPDGLPLFGQGRHGTPLANAQDKPILSLGGKPLVGLE--VIKKT THPP-TT-----TMQP---------TTTTTPLP--------T--TTTPRPT-----T--- --------AT-----TRRT--TTT------------------------------------ ---RR-T-TTRR-------PTTTVR--------TTTR-----------------TT--TT ----------TTPTP-------------TT------------------------------ -PIPTCPPGTLERHDDDGNLIM-SSNGIPECY--------------------------A- ------------------------EEDEFSGLETD--------TAVPTEEAYVIYDE--- ---------------------D--------YE-FE-TSR-------P-----P---T--- -------TTEPS-------------------------------------------TTA-- TTPR-----------VIPEEGA----------------------I--------------- -----SSFPEEEFDLAGRKRFV--------------------------APYVTYLNKDPS APCSLTDALDHFQVDSLDEIIPND--LKKSDLPPQHAPRNITVVAVEGCHSFVIVDWDKA TPGDVVTGYLVYSASYEDFIRNKWSTQASSVTHLPIENLKPNT----------------- -------------RYYFKVQAQNPHGYGPISPSVSFVTESDNPLLVVRPPG--------- ------GEPIWIPFAFKHDPSYTDCHGRQYVKRTWYRKFVGVVLCNSLRYKIYLSDNL-K -DTFYSIGDSWGRGEDHCQFVDSHLDGRTGPQSYVEALPTIQGYYRQYRQEPVRFGNIGF GTPYYYVGWYECGVSIPGKW---------------------------------------- ------------------------------------------------------ >ENSGGOP00000014547 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------------MA-------- ---PEAGATLRAPRR-LSWAA-LLLLAALLPVASSAG-AP-------------------- ------------------------------------------------VDHPL------- -----------------------KPRHVKLLSTKMGLKVTWDPPKDATSRPV----EHYN ------------------------------------------------------I-AYGK S-----------------------------------------------LK---------- -----------SLKYIKVNAETYSFLIEDV--------------------------EPGV VYFVLLTAENHS--------GVSRPVYRAESPP--------------------------- -------------------------------------------------------GG--- ---------------------------------EWIEIDGFPIKGPGP------------ ------------------FNETVT------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------EKEVPNKPLRVRVRSS-------------------------------------- -----------------DDRLSVAWKAPRL-SGAKS-------PR-RSRGFLLGYG---- -ESGRKMSY------------VPLTRDERTHEIKKL---ASESV---------------- ---------YVVSLQSMN-----------------SQGRSQPVYRAALTKRKISEE---- ---DELDVPDDISVRVMSSQSVLVSWVDPVLE-KQKKVV--AS-RQYTVRYREKGELARW DYKQIANRRVLIENLIPDTVYEFAVRISQGERDGKWSTSVFQRTPESAPTTAPENLNVWP VNGKPTVVAASWDALPETEGKVKEYILSYAPALKPFGAKSLTYPGDATSALVDGLQPGER YLFKIRAANRRGLGPHSKAFIVAMPT-----------T-S--KADVQQ--NTEDNGKPEK PE----------------------------------------------PSSPSPRAPA-- -------SSQHPS-V--------------------------------------------- --------PASPQGRSAKDLLLDLKNKILANGGAPRKPQLRAKKAEEL---DLQS----T EITG-------EEELGPP------------------------------------------ ----------------RP--PSRHGHSVVAPGRTAVRARMPALPRREGVDK-PRFSLATQ --------PR---------------------------------------PGAPPSASA-S PAHHASTQ---------------------------------------------------- -----------------------------GTSHR--------------------P----- ------------------------------------------------------------ ------------------S-----------LPASLNDN---------------------- ----------------------DLVDSDEDERAVGSLHPKG------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------------------AFAQ PRPALSPSRQSPSSVLRDRSSVHPSAKPASPA-------------------RRTP----- --------H-------------------------SGAAEEDSNASAP------------- ------PSR---------------------------LSPPHGGSSRLLPTQPHLGS---- -------PLSRGGKDGEDAPATNSN---------------APSRSTMS------------ -----------SSVSSR------------------------------------------- ------------------------------------------------------------ LSSRTQVSE------------------------------------------GAEASDGES HGDGDREDGGRQAEATAQTLRA---------R---------------------------- ------------PASGHFHLLRHKPFAANGRSPSRFSIGRGPRLQPSSS---PQS---TV PSRAH------------------------------------------------------- --------------------PRVPSHSDS------------------------------- HPKLSSGIHGD--------------------------EEDEKPLP-------------AT ------------------------------------------------------------ ---------------------VVNDH-V------------P-----------------SS S------------------RQPISRGWEALRRSPQRGASLHRKEPIPENP---------- -------------------------------KST-------------------------- ----------------------------------------------------------GA --------------------------DTHPQGKY-------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------SSLASKAQDVQQS-TDADTEGHSPKAQ PGSTDRHASPARP----------------------------------------------- ---------------------------------------------------PAE------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------RSQH----------------- ------------------------------------------------------------ ---------------------------------------------------H---PSVPR RMTPGR--------------------APEQQPSPPVATSQ-NHP-GPQSRDAGRSPSQPR LSLT-QAGRP---------------------RPTSQ------------------------ ------------------------------------------------------------ ---------------GRSHSSSD------------------------------------- ---------------------------SYT-----------------------------A SS--------------------RGMLPTALQNQ--------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -D---------------------------------------------------------- ----------EDAQG--------------------------------------------- ---------------------------SYDDDST-------------------------- ---------------EVEAQDVRGPAHAAR------------------------------ --------------------------------------AKE------------------- ------------------------------------------------------------ ----------------------AAASLPKHQQV--------------------------- ------ESPTGAGAGGDHRSQRGH------------------------------------ ------------------------------------------------------------ ------------------------------------------------AGSP-------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------ARPSR---------------------------------- ------------------------------------------------------------ ----------------P------------------------------------------- -----------------------GG-------------------PQSRARVP-------- -------------------------------------------------------SRAA- -------------P--GKSTPPSKRPLSS------------------------------- ----------KSQQSVSAE----------------DE-EEEDAGFFKGGKE-DLLSSSVP KWPSSST-PRGGKDADG------------------------------SLAKEERE----- --------------------------------------------------PAIALAP--- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------RGG------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----SL------------------------------------------------------ -------------------APV-------------------------------------- -------------------KRPLPPP-P-------------------------------- ------------------------------------------------------------ ------------------------------G------------------SY--PRASHVP SRPPP-----------RSA----------------------------ATVS--------- ---------------------------------PVAGTHPWPR----------------- --------------YTTRAPPGH------------------------------------- ----SST-T--------------------------------------------------- ------------------------------PML----------SLRQRMMH--------- ----A----------RFRNPL-----SRQ-------------PA---------------- ------------------------------------------------------------ ---------------------------RPSY------R------Q--------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------GYNGRPNV----------- --EGK---VLPGSNGKPNGQRIINGPQGTKWVVDLDRGLVLNAEGRYLQDSHGNPLRIKL GGDGRTIVDLEGTPVVSPDGLPLFGQGRHGTPLASAQDKPILSLGGKPLVGLE--VIKKT THPP-TT-----TTQP---------TTTTTPLP--------T--TTTPRPT-----T--- --------AT-----TRRT--TTT------------------------------------ ---RR-T-TTRR-------PTTTVR--------TTTR-----------------TT--TT ----------TTPKP-------------TT------------------------------ -PIPTCPPGTLERHDDDGNLIM-SSNGIPECY--------------------------A- ------------------------EEDEFSGLETD--------TAVPTEEAYVIYDE--- ---------------------D--------YE-FE-TSR-------P-----P---T--- -------TTEPS-------------------------------------------TTA-- TTPR-----------VIPEEGA----------------------I--------------- -----SSFPEEEFDLAGRKRFV--------------------------APYVTYLNKDPS APCSLTDALDHFQVDSLDEIIPND--LKKSDLPPQHAPRNITVVAVEGCHSFVIVDWDKA TPGDVVTGYLVYSASYEDFIRNKWSTQASSVTHLPIENLKPNT----------------- -------------RYYFKVQAQNPHGYGPISPSVSFVTESDNPLLVVRPPG--------- ------GEPIWIPFAFKHDPSYTDCHGRQYVKRTWYRKFVGVVLCNSLRYKIYLSDNL-K -DTFYSIGDSWGRGEDHCQFVDSHLDGRTGPQSYVEALPTIQGYYRQYRQEPVRFGNIGF GTPYYYVGWYECGVSIPGKW---------------------------------------- ------------------------------------------------------ >ENSPPAP00000040367 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------------M--------- ---------------------------------------SLLTCDSSLTGLQE------- -----PHLWSWEGML-------------------------FDSCAVYIVDHPL------- -----------------------KPRHVKLLSTKMGLKVTWDPPKDATSRPV----EHYN ------------------------------------------------------I-AYGK S-----------------------------------------------LK---------- -----------SLKYIKVNAETYSFLIEDV--------------------------EPGV VYFVLLTAENHS--------GVSRPVYRAESPP--------------------------- -------------------------------------------------------GG--- ---------------------------------EWIEIDGFPIKGPGP------------ ------------------FNETVT------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------EKEVPNKPLRVRVRSS-------------------------------------- -----------------DDRLSVAWKAPRL-SGAKS-------PR-RSRGFLLGYG---- -ESGRKMNY------------VPLTRDERTHEIKKL---ASESV---------------- ---------YVVSLQSMN-----------------SQGRSQPVYRAALTKRKISEE---- ---DELDVPDDISVRVMSSQSVLVSWVDPVLE-KQKKVV--AS-RQYTVRYREKGELARW DYKQIANRRVLIENLIPDTVYEFAVRISQGERDGKWSTSVFQRTPESAPTTAPENLNVWP VNGKPTVVAASWDALPETEGKVKEYILSYAPALKPFGAKSLTYPGDTTSALVDGLQPGER YLFKIRAANRRGLGPHSKAFIVAMPT-----------T-S--KADVQQ--NTEDNGKPEK PE----------------------------------------------PSSPSPRAPA-- -------SSQHPS-V--------------------------------------------- --------PASPQGRNAKDLLLDLKNKILANGGAPRKPQLRAKKAEEL---DLQS----T EITG-------EEELGSREDSPMSPSD-------------TQD----------------- -----------QKRTLRP--PSRHGHSVVAPGRTAVRARMPALPRREGVDK-PGFSLATQ --------PR---------------------------------------PGAPPSASA-S PAHHASTQ---------------------------------------------------- -----------------------------GTSHR--------------------P----- ------------------------------------------------------------ ------------------S-----------LPASLNDN---------------------- ----------------------DLVDSDEDELAVGSLHPKG------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------------------AFAQ PRPALSPSRQSPSSVLRDRSSVHPGAKPASPA-------------------RRTP----- --------H-------------------------SGAAEEDSSASAP------------- ------PSR---------------------------LSPPHGGSSRLPPTQPHLGS---- -------PLSRGGKDGEDAPATNSN---------------APSRSTMS------------ -----------SSVSSR------------------------------------------- ------------------------------------------------------------ LSSRTQVSE------------------------------------------GAEASDGES HGDGDREDGGRQAEATAQTLRA---------R---------------------------- ------------PASGHFHLLRHKPFAANGRSPSRFSIGRGPRLQPSSS---PQS---TV PSRAH------------------------------------------------------- --------------------PRVPSHSNS------------------------------- HPKLSSGIHRD--------------------------EEDEKPLP-------------AT ------------------------------------------------------------ ---------------------VVNDH-V------------P-----------------SS S------------------RQPISRGWEALRRSPQRGASLHRKEPIPENP---------- -------------------------------KST-------------------------- ----------------------------------------------------------GA --------------------------DTHPQGKY-------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------SSLASKAQDVQQS-TDADTEGHSPKAQ PGSTDRHASPARP----------------------------------------------- ---------------------------------------------------PAA------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------RSQQ----------------- ------------------------------------------------------------ ---------------------------------------------------H---PSVPR RMTPGR--------------------APEQQPPPPVATSQ-HHP-GPQSRDEGRSHSQPR LSLT-QAGRP---------------------RPTSQ------------------------ ------------------------------------------------------------ ---------------GRSHSSSD------------------------------------- ---------------------------PYT-----------------------------A SS--------------------RGMLPTALQNQ--------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -D---------------------------------------------------------- ----------EDAQG--------------------------------------------- ---------------------------SYNDDST-------------------------- ---------------EVEAQDVRAPAHAAR------------------------------ --------------------------------------AKE------------------- ------------------------------------------------------------ ----------------------AAASLPKHQQV--------------------------- ------ESPTGAGAGGDHRSQRGH------------------------------------ ------------------------------------------------------------ ------------------------------------------------AGSP-------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------ARPSR---------------------------------- ------------------------------------------------------------ ----------------P------------------------------------------- -----------------------GG-------------------PQSRARVP-------- -------------------------------------------------------SRAA- -------------P--GKSESPSKRPLSS------------------------------- ----------KSQQSVSAE----------------DE-EEEDAGFFKGGKE-DLLSSSVP KWPSSST-PRGGKDADG------------------------------SLAKEERE----- --------------------------------------------------PAIALAP--- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------RGG------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----SL------------------------------------------------------ -------------------APV-------------------------------------- -------------------KQPLPPP-P-------------------------------- ------------------------------------------------------------ ------------------------------G------------------SS--PRASHVP SRPPP-----------RSA----------------------------ATVS--------- ---------------------------------PVAGTHPWPR----------------- --------------YTTSAPPGH------------------------------------- ----SST-T--------------------------------------------------- ------------------------------PML----------SLRQRMMH--------- ----A----------RFRNPL-----SRQ-------------PA---------------- ------------------------------------------------------------ ---------------------------RPSY------R------Q--------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------GYNGRPNV----------- --EGK---VLPGSNGKPNGQRIINGPQGTKWVVDLDRGLVLNAEGRYLQDSYGNPLRIKL GGDGRTIVDLEGTPVVSPDGLPLFGQGRHGTPLANAQDKPILSLGGKPLVGLE--VIKKT THPP-TT-----TTQP---------TTTTTPLP--------T--TTTPRPT-----T--- --------AT-----TRRM--TTT------------------------------------ ---RR-T-TTRR-------PTTTVR--------TTTR-----------------TT--TT ----------TTPKP-------------TT------------------------------ -PIPTCPPGTLERHDDDGNLIM-SSNGIPECY--------------------------A- ------------------------EEDEFSGLETD--------TAVPTEEAYVIYDE--- ---------------------D--------YE-FE-TSR-------P-----P---T--- -------TTEPS-------------------------------------------TTA-- TTPR-----------VIPEEGA----------------------I--------------- -----SSFPEEEFDLAGRKRFV--------------------------APYVTYLNKDPS APCSLTDALDHFQVDSLDEIIPND--LKKSDLPPQHAPRNITVVAVEGCHSFVIVDWDKA TPGDVVTGYLVYSASYEDFIRNKWSTQASSVTHLPIENLKPNT----------------- -------------RYYFKVQAQNPHGYGPISPSVSFVTESDNPLLVVRPPG--------- ------GEPIWIPFAFKHDPSYTDCHGRQYVKRTWYRKFVGVVLCNSLRYTIYLSDNL-K -DTFYSIGDSWGRGEDHCQFVDSHLDGRTGPQSYVEALPTIQGYYRQYRQEPVRFGNIGF GTPYYYVGWYECGVSIPGKW---------------------------------------- ------------------------------------------------------ >ENSPPYP00000019196 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------RPPWRIQAAGYLPVTIL VQQESVPHLSLAKQRDRRGDTKAAPWHPPESGQHTPASREHPAPAHPGLPMA-------- ---PEAGETMRAPPP-LSWAA-LLLLAALIPVASSAG-AS-------------------- ------------------------------------------------VDHPL------- -----------------------KPRHVKLLSTKMGLKVTWDPPKD---RPV----EHYN ------------------------------------------------------I-AYGK S-----------------------------------------------LK---------- -----------SLKYIKVNAETYSFLIEDV--------------------------EPGV VYFVLLTAENHS--------GVSRPVYRAESPP--------------------------- -------------------------------------------------------GG--- ---------------------------------EWIEIDGFPIKGPGP------------ ------------------FNETVT------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------EKEVPNKPLRVRVRSS-------------------------------------- -----------------DDRLSVAWKAPRL-SGAKS-------PR-RSRGFLLGYG---- -ESGRKMNY------------VPLTRDERTHEIKKL---ASESV---------------- ---------YVVSLQSMN-----------------SQGRSQPVYRAALTKRKISEE---- ---DELDVPDDISVRVMSSQSVLVSWVDPVLE-KQKKVV--AS-RQYTVRYREKGELARW DYKQIANRRVLIENLIPDTVYEFAVRISQGERDGKWSTSVFQRTPESAPTTAPENLNVWP VNGKPTVVAASWDALPETEGKVKEYILSYAPALKPFGAKSLTYPGDTTSALVDGLQPGER YLFKIRAANRRGLGPHSKAFIVAMPT-----------T-S--KADVQQ--NTEDNGKPEK PE----------------------------------------------PSSPSPRAPA-- -------SSQHPS-V--------------------------------------------- --------PASPQGRNAKDLLLDLKNKILANGGAPRKPQLRAKKAEEL---DLQS----T EVTG-------EEELGSREDSPMSPSD-------------TQD----------------- -----------QKRTLRP--PSRHGHSVVAPGRTAVRARVPALPRREGVDK-PGFSLATQ --------PR---------------------------------------PGAPPSASA-S PAHHASTQ---------------------------------------------------- -----------------------------GTSHR--------------------P----- ------------------------------------------------------------ ------------------S-----------LPASLNDN---------------------- ----------------------DLVDSDEDERAAGSLHPKG------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------------------AFAQ PRPALSPSRQSPSSVLRDRSSVHPGAKPASPA-------------------RRTP----- --------H-------------------------SGAAEEDSSASAP------------- ------PSR---------------------------LSPPHGGSSRLLPTQPHLGP---- -------PLSRGGKDGEDAPATNSN---------------APSRSTM------------- -----------SSVSSR------------------------------------------- ------------------------------------------------------------ LSSRTQISE------------------------------------------GAEASDGES DSDGDSEDGGRQAEATAQTLRA---------R---------------------------- ------------PASGLFHLLRHKPFAANGRSPGRFSTGRGPRLQPSSS---PQS---TV PYRAH------------------------------------------------------- --------------------PRVPSHSDS------------------------------- HPRLSSGIHGD--------------------------EEDEKPLP-------------AT ------------------------------------------------------------ ---------------------VVNDH-V------------P-----------------SS S------------------RQPISRGWEALRRSPQRGASLHQKEPIPENP---------- -------------------------------KST-------------------------- ----------------------------------------------------------GA --------------------------DAHPQGKY-------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------SSLASKAQDVQQS-TDADTEGHSPKAQ PGSTDRHASPARP----------------------------------------------- ---------------------------------------------------PAA------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------RSQH----------------- ------------------------------------------------------------ ---------------------------------------------------H---PSVPR RMTPGR--------------------APEQQPPPPVATSQ-HQP-GPQSRDAGRSPSQPR LSLT-QAGRP---------------------RPTSQ------------------------ ------------------------------------------------------------ ---------------GRSHSSSD------------------------------------- ---------------------------PYT-----------------------------A SS--------------------RGMLPTALQNQ--------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -D---------------------------------------------------------- ----------EDAQG--------------------------------------------- ---------------------------SYDDDST-------------------------- ---------------EVEAQDVRAPAQAAR------------------------------ --------------------------------------AKE------------------- ------------------------------------------------------------ ----------------------AAASLPKHQQV--------------------------- ------ESPTGAGAGGDHRSQRGH------------------------------------ ------------------------------------------------------------ ------------------------------------------------AGSP-------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------ARPSR---------------------------------- ------------------------------------------------------------ ----------------P------------------------------------------- -----------------------GG-------------------PQSRARVP-------- -------------------------------------------------------SRAA- -------------P--GKSEPPSKRPLSS------------------------------- ----------KSQQSVSAE----------------DE-EEEDVGFFKGGKE-DLLSSSVP KWPSSST-PRGGKDADG------------------------------SLAKDERE----- --------------------------------------------------PAIALAP--- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------RGG------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----SL------------------------------------------------------ -------------------APV-------------------------------------- -------------------KRPLSPP-P-------------------------------- ------------------------------------------------------------ ------------------------------G------------------TS--PRASHLP SRPPP-----------RSA----------------------------ATVS--------- ---------------------------------PVAGTHPWPQ----------------- --------------YTTRAPPGH------------------------------------- ----SST-T--------------------------------------------------- ------------------------------PML----------SLRQRMMH--------- ----A----------RFRNPL-----SRQ-------------PA---------------- ------------------------------------------------------------ ---------------------------RPSY------R------Q--------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------GYNGRPNV----------- --EGT---VLPGSNGKPNGQRIINGPQGTKWVVDLDRGLVLNAEGRYLQDSHGNPLRIKL GGDGRTIVDLEGTPVVSPDGLPLFGQGRHGTPLASAQDKPILSLGGKPLVGLE--VIKTT THP-----------------------------L--------T--TTTPRPT-----T--- --------AT-----TRRT--TTT------------------------------------ ---RR-T-TTRR-------PTTTIR--------TTTR-----------------TT--TT ----------TTPNP-------------TT------------------------------ -PIPTCPSGTLERHDDDGNLIM-SSNGIPECY--------------------------A- ------------------------EEDEFSGLETD--------TAVPTEEAYVIYDE--- ---------------------D--------YE-FE-TSR-------P-----P---T--- -------TTEPS-------------------------------------------TTA-- TTPR-----------VIPEEGA----------------------I--------------- -----SSFPEEEFDLAGRKRFV--------------------------APYVTYLNKDPS APCSLTDALDHFQVDSLEEIIPND--LKKSDLPPQHAPRNITVVAVEGCHSFVIVDWDKA TPGDVVTGYLVYSASYEDFIRNKWSTQASSVTHLPIENLKPNT----------------- -------------RYYFKVQAQNPHGYGPISSSVSFVTESDNPLLVVRPPG--------- ------GEPIWIPFAFKHDPSYTDCHGRQYVKRTWYRKFVGVVLCNSLRYKIYLSDNL-K -DTFYSIGDSWGRGEDHCQFVDSHLDGRTGPQSYVEALPTIQGYYRQYRQEPVSFGNIGF GTPYYYVGWYECGVSIPGKW---------------------------------------- ------------------------------------------------------ >ENSCJAP00000043145 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------------MA-------- ---PEAGAPLRAPRQ-LPWAALLLLVAALLPVASSAG-AP-------------------- ------------------------------------------------VDHPL------- -----------------------KPRHVKLLSTKMGLKVTWDPPKDATSRPV----EHYN ------------------------------------------------------I-AYGK S-----------------------------------------------LK---------- -----------SLKYIKVNAETYSFLIEDV--------------------------EPGV VYFVLLTAENHS--------GVSRPVYRAESPP--------------------------- -------------------------------------------------------GG--- ---------------------------------EWIKIDGFPIKGPGP------------ ------------------FNETVT------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------EKEVPNKPLRVRVRSS-------------------------------------- -----------------DDRLSVAWKAPRL-SGAKS-------PR-RSRGFLLGYG---- -ESGRKMNY------------VPLTRDERTHEIKKL---ASESV---------------- ---------YVVSLQSMN-----------------SQGRSQPVYRAALTKRKISEE---- ---DELDVPDDISVRVMSSQSVLVSWVDPALE-KQKKVV--AS-RQYAVRYREKGELARW DYKQTTNRRVLIENLIPDTVYEFAVRISQGERDGKWSTSVFQRTPESAPTTAPENLNVWP VNGKPTVVTASWDALPETEGKVKEYILSYAPALKPFGAKSLTYPGDTTSALVDGLQPGER YLFKIRAANRRGLGPHSKAFIVAMPA-----------T-S--KADVQQ--NTEDNGKPEK PE----------------------------------------------PSSPSPRAPA-- -------SP--------------------------------------------------- -------------GRNAKDLLLDLKNKILANGGASRKPQLHAKKAEEL---DLQL----T EVTG-------KEELGSQEDSPTSPSN-------------TQD----------------- -----------QKRPLRP--PSRHGHSVVAPGRTAVRARMPALPQREGVDK-PAFSPATH --------PR---------------------------------------PGTAPAASA-S HAHHAVTQ---------------------------------------------------- -----------------------------GTSHR--------------------P----- ------------------------------------------------------------ ------------------S-----------LPARLNDN---------------------- ----------------------DSVDSDEDELAVGSLHPNG------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------------------ASAQ PRPALSPSRLSPSSVLRDRSSVYPGSKPDSPA-------------------RRTP----- --------H-------------------------SGAAEEDSSASAP------------- ------PSR---------------------------LSPPHGGSSRLL--QPHLGP---- -------PLSRGGKDAEDAPATNSN---------------SPSRSTTS------------ -----------SLVSSR------------------------------------------- ------------------------------------------------------------ LSSRTQASE------------------------------------------GVEASDGKG DGDSDTEDSGRQAEATAQTLRT---------R---------------------------- ------------PASGHFHLLRHKSFAANGRAPSRFGIGRSPRLQPSSS---PQS---TV PSRAH------------------------------------------------------- --------------------SRVHSHPAS------------------------------- HPRLGSGIHGD--------------------------EEDEKPLP-------------AT ------------------------------------------------------------ ---------------------VVNDH-V------------P-----------------SS S------------------RQPISRGWEALRRTPQRGASLHRKEPIPENP---------- -------------------------------KSA-------------------------- ----------------------------------------------------------GA --------------------------DAHPQGKY-------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------STLSSKAQDVQQS-TDADTEGHSPKAQ PGSTGRHASPARP----------------------------------------------- ---------------------------------------------------PAA------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------RPQH----------------- ------------------------------------------------------------ ---------------------------------------------------HPG-PSVPR RTTPGR--------------------APEQQPPPPVSTSQ-NQP-GPQSRDTGRSPSQPR LSQA-QAGRP---------------------LPTSQ------------------------ ------------------------------------------------------------ ---------------GRSH-SSD------------------------------------- ---------------------------PYT-----------------------------A SS--------------------RGVLTSALQNQ--------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -D---------------------------------------------------------- ----------EDGRG--------------------------------------------- ---------------------------SYDDDST-------------------------- ---------------EVEAQDVRAPAHAAR------------------------------ --------------------------------------AKD------------------- ------------------------------------------------------------ ----------------------PDAFLPK-QQM--------------------------- ------ESPTGASAGGDDRSQRGH------------------------------------ ------------------------------------------------------------ ------------------------------------------------VSSP-------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------ARPSR---------------------------------- ------------------------------------------------------------ ----------------P------------------------------------------- -----------------------SG-------------------PQFRARVP-------- -------------------------------------------------------GRAS- -------------P--GKSEPPSKRPLSS------------------------------- ----------KSQQSVSA-----------------EE-EEEDAGIFKGGKE-DL--SSVR KWPSSST-PRGGKYADG------------------------------SFAKDERE----- --------------------------------------------------PAIVLAP--- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------RGG------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----SL------------------------------------------------------ -------------------APA-------------------------------------- -------------------KRPLPPP-P-------------------------------- ------------------------------------------------------------ ------------------------------G------------------SS--PRASHLP SRPPP-----------RSA----------------------------ATAS--------- ---------------------------------PVAGTHPWPR----------------- --------------YTTRSPPSH------------------------------------- ----SST-T--------------------------------------------------- ------------------------------PML----------SLRQRMMH--------- ----A----------RFRNPL-----SRQ-------------PA---------------- ------------------------------------------------------------ ---------------------------RPSY------R------Q--------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------GYNGRPNV----------- --EGK---VLPGSNGKPNGQRIINGPQGTKWVVDLDRGLVLNAEGRYLQDSHGNPLRIKL GGDGRTIVDLEGTPVVSPDGLPLFGQGRHGTPLASAQDKPILSLGGKPLVGLE--VIKTT THPP-TT-----TTRA---------TTTTTPLP--------T--TTTLRPT-----T--- --------AI-----THRT--ATT------------------------------------ ---RR-T-TTRR-------PTTTIR--------TTMR-----------------TT--TT ----------TTPKP-------------TT------------------------------ -PIPTCPPGTLERHDDDGNLIM-GSNGIPECY--------------------------A- ------------------------EEDEFSGLETD--------TAVPTEEAYVIYDE--- ---------------------D--------YE-FE-TSR-------P-----P---T--- -------TTEPS-------------------------------------------TTA-- TTPR-----------VIPEEGA----------------------I--------------- -----GSFPEEEFDLAGRKRFV--------------------------APYVTYLNKDPL APCSLTDALDHFQVDSLDEIIPND--LRKSDLPPQHAPRNITVVAVEGCHSFVIVDWDKA TPGDVVTGYLVYSASYEDFIRNKWSTQASSVTHLPIENLKPNT----------------- -------------RYYFKVQAQNPHGYGPISPSVSFVTESDNPLLVVRPPG--------- ------GEPIWIPFAFKHDPGYTDCHGRQYVKRTWYRKFVGVVLCNSLRYKIYLSDNL-K -DTFYSIGDSWGRGEDHCQFVDSHLDGRTGPQSYVEALPTIQGYYRQYRQEPVSFGNIGF GTPYYYVGWYECGVSIPGKW---------------------------------------- ------------------------------------------------------ >ENSANAP00000022046 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------DSCAVYIVDHPL------- -----------------------KPRHVKLLSTKMGLKVTWDPPKDATSRPV----EHYN ------------------------------------------------------I-AYGK S-----------------------------------------------LK---------- -----------SLKYIKVNAETYSFLIEDV--------------------------EPGV VYFVLLTAENHS--------GVSRPVYRAESPP--------------------------- -------------------------------------------------------GG--- ---------------------------------EWIKIDGFPIKGPGP------------ ------------------FNETVT------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------EKEVPNKPLRVRVRSS-------------------------------------- -----------------DDRLSVAWKAPRL-SGAKS-------PR-RSRGFLLGYG---- -ESGRKMNY------------VPLTRDERTHEIKKL---ASESV---------------- ---------YVVSLQSMN-----------------SQGRSQPVYRAALTKRKISEE---- ---DELDVPDDISVRVMSSQSVLVSWVDPVLE-KQKKVV--AS-RQYTVRYREKGELARW DYKQITNRRVLIENLIPDTVYEFAVRISQGERDGKWSTSVFQRTPESAPTTAPENLNVWP VNGKPTVVTASWDALPETEGKVKEYILSYAPALKPFGAKSLTYPGDTTSALVDGLQPGER YLFKIRAANRRGLGPHSKAFIVAMPA-----------T-S--KADDQQ--NTEDNGKPEK PE----------------------------------------------PSSPSPRPPA-- -------SP--------------------------------------------------- -------------GRNAKDLLLDLKNKILANGGAPRKPQLRAKKAEEL---DLQS----T EVTG-------KEELGSQEDSPTSPSD-------------TQD----------------- -----------QKRPLRP--PSRHGHSVVAPGRTAVRARMPVLPRREGVDK-PGFSPATH --------PR---------------------------------------PGTAPAASA-S PAHHAATQ---------------------------------------------------- -----------------------------STSHR--------------------P----- ------------------------------------------------------------ ------------------S-----------PRARFNDN---------------------- ----------------------DSVDSDEDELAVGSLHPKG------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------------------ASAQ PRPALSPSRLSPSSVLRDRSSVYPGAKPASPA-------------------RRTP----- --------H-------------------------SGAAEEDSSASAS------------- ------PSR---------------------------LSPPHGGSSRLLPTQPHLGP---- -------PLSRGGKDGEDAPATNSN---------------SPSRSATS------------ -----------SSVFSR------------------------------------------- ------------------------------------------------------------ LSSRTQVSE------------------------------------------GAEASDGEG DGDSDTEDSGRQAEATAQTQRT---------R---------------------------- ------------PASGHFHLLRHKPFAANGRAPSRFGIGRTPRLQPSSS---PQS---TV PSRAH------------------------------------------------------- --------------------SRVHSHPAS------------------------------- HPRLGSGIHGD--------------------------EEDEKPLP-------------AT ------------------------------------------------------------ ---------------------VVNDH-V------------P-----------------SF S------------------RQPISRGWEALRRSPQRGASLHRKEPIPENP---------- -------------------------------KSA-------------------------- ----------------------------------------------------------GA --------------------------DAHPQGKY-------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------STLSSKAQDVQQS-TDADTEGHSPKAQ LESTGRHASPARS----------------------------------------------- ---------------------------------------------------LAP------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------RPQH----------------- ------------------------------------------------------------ ---------------------------------------------------HPG-PSVPR RTTPGR--------------------APEQQPPPPDSTSQ-NQP-GPQSRDTGRSPSQPR LAQA-QAGRP---------------------IPQSQ------------------------ ------------------------------------------------------------ ---------------GRSH-SSD------------------------------------- ---------------------------PYT-----------------------------A SS--------------------RGVLPSALQNR--------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -D---------------------------------------------------------- ----------EDGRG--------------------------------------------- ---------------------------SYDDDST-------------------------- ---------------EVEAQDVRAPAHAAR------------------------------ --------------------------------------AKD------------------- ------------------------------------------------------------ ----------------------AVASLPK-QQL--------------------------- ------ESPTGASAGGNDRSQRGH------------------------------------ ------------------------------------------------------------ ------------------------------------------------ASSP-------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------ARPSR---------------------------------- ------------------------------------------------------------ ----------------P------------------------------------------- -----------------------SG-------------------PQFRARVP-------- -------------------------------------------------------GRAT- -------------P--GKSEPPSKRPLSS------------------------------- ----------KSQQSISAE----------------EE-EEEDAGIFKGGKE-DLLSSSVR KWPSSST-PRGGKYADG------------------------------SFAKDERE----- --------------------------------------------------PAIALAP--- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------RGG------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----SL------------------------------------------------------ -------------------APA-------------------------------------- -------------------KRPLPSP-P-------------------------------- ------------------------------------------------------------ ------------------------------G------------------SS--PRASHLP SRPPP-----------RSA----------------------------ATAS--------- ---------------------------------SISGTHPWPR----------------- --------------YTTRSPPSH------------------------------------- ----SST-T--------------------------------------------------- ------------------------------PML----------SLRQRMMH--------- ----A----------RFRNPL-----SRQ-------------PA---------------- ------------------------------------------------------------ ---------------------------RPSY------R------Q--------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------GYNGRPNV----------- --EGK---VLPGSNGKPNGQRIINGPQGTKWVVDLDRGLVLNAEGRYLQDSHGNPLRIKL GGDGRTIVDLEGTPVVSPDGLPLFGQGRHGTPLASAQDKPILSLGGKPLVGLE--VIKTT THPP-TT-----TTRP---------TTTTTPLP--------T--TTTPRPT-----T--- --------AT-----TLRT--TTT------------------------------------ ---RR-T-TTRR-------PTTTIR--------TTMR-----------------TT--TT ----------TTPKP-------------TT------------------------------ -PIPTCPPGTLERHDDDGNLIM-GSNGIPECY--------------------------A- ------------------------EEDEFSGLETD--------TAVPTEEAYVIYDE--- ---------------------D--------YE-FE-TSR-------P-----P---T--- -------TTEPS-------------------------------------------TTA-- TTPR-----------VIPEEGA----------------------I--------------- -----SSFPEEEFDLAGRKRFV--------------------------APYVTYLNKDPS APCSLTDALDHFQVDSLDEIIPND--LRKSGLPPQHAPRNITVVAVEGCHSFVIVDWDKA APGDVVTGYLVYSASYEDFIRNKWSTQASSVTHLPIENLKPNT----------------- -------------RYYFKVQAQNPHGYGPISPSVSFVTESDNPLLVVRPPG--------- ------GEPIWIPFAFKHDPGYTDCHGRQYVKRTWYRKFVGVVLCNSLRYKIYLSDNL-K -DTFYSIGDSWGRGEDHCQFVDSHLDGRTGPQSYVEALPTIQGYYRQYRQEPVSFGNIGF GTPYYYVGWYECGVSIPGKW---------------------------------------- ------------------------------------------------------ >ENSCCAP00000008475 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------------MA-------- ---PEAGAPLRAPRQ-LPWAA-LLLVAALLPVASSAG-AP-------------------- ------------------------------------------------VDHPL------- -----------------------KPRHVKLLSTKMGLKVTWDPPKDATSRPV----EHYN ------------------------------------------------------I-AYGK S-----------------------------------------------LK---------- -----------SLKYIKVNAETYSFLIEDV--------------------------EPGV VYFVLLTAENHS--------GVSRPVYRAESPP--------------------------- -------------------------------------------------------GG--- ---------------------------------EWIKIDGFPIKGPGP------------ ------------------FNETVT------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------EKEVPNKPLRVRVRSS-------------------------------------- -----------------DDRLSVAWKAPRL-SGAKS-------PR-RSRGFLLGYG---- -ESGRKMNY------------VPLTRDERTHEIKKL---ASESV---------------- ---------YVVSLQSMN-----------------SQGRSQPVYRAALTKRKISEE---- ---DELDVPDDISVRVMSSQSVLVSWVDPVLE-KQKKVV--AS-RQYTVRYREKGELARW DYKQITNRRVLIENLIPDTVYEFAVRISQGERDGKWSTSVFQRTPESAPTTAPENLNVWP VNGKPTVVTASWDALPETEGKVKEYILSYAPALKPFGAKSLTYPGDTTSALVDGLQPGER YLFKIRAANRRGLGPHSKAFIVALPA-----------T-S--KADVQQ--NTEDNGKPEK PE----------------------------------------------RSSLSPRPPA-- -------SP--------------------------------------------------- -------------GRNAKDLLLDLKNKILANGGAPRKPQLRAKKAEEL---DLQS----R ELTG-------KEELGSQEDSPTSPSD-------------TQD----------------- -----------QKRPLRP--PSRPGHSVVAPGRTAVRARMPALPRREGVDK-PSFFPATH --------PR---------------------------------------PGTAPAASA-S PAHHAATQ---------------------------------------------------- -----------------------------DTSHR--------------------P----- ------------------------------------------------------------ ------------------S-----------LPARFNDN---------------------- ----------------------DSVDSDEDELAVGSLHPKG------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------------------ASVQ PRPALSPSRLYPSSVLRDRSSVYPGAKPTSPV-------------------RRTP----- --------H-------------------------SGAAEEDSSALAP------------- ------PSR---------------------------LSPPHGGSSRLLPTQPHLGP---- -------PLSRGGKDGKDTPATNSN---------------SPSRSATS------------ -----------SSASSR------------------------------------------- ------------------------------------------------------------ LSSRTQMSE------------------------------------------GAEPSDGEG DGDSDTEDSGRQAEATAQTLRT---------R---------------------------- ------------PASGHFHLLRHKPFAANGRAPSRFGIGRGPRLQPSSS---PQS---TV PSRAH------------------------------------------------------- --------------------SRVHSHPAS------------------------------- HPRLGSGIHGD--------------------------EEDEKPLP-------------AT ------------------------------------------------------------ ---------------------IVNDH-V------------P-----------------SS S------------------RQPISRGWEALRRSPQRGASLHRKEPIPENP---------- -------------------------------KST-------------------------- ----------------------------------------------------------GA --------------------------DAHPQGKY-------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------STLSSKAQDVQQS-TDADTEGHSPKAQ PGSTGRHTSPARP----------------------------------------------- ---------------------------------------------------PAA------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------RPQH----------------- ------------------------------------------------------------ ---------------------------------------------------HPG-PSVPR RTTPGR--------------------APEQQTPPPVSTSR-NQP-GPQSRDTGRSPSQPR LAQA-QAGRP---------------------LPTSQ------------------------ ------------------------------------------------------------ ---------------GRFHSSSD------------------------------------- ---------------------------PYT-----------------------------A NS--------------------RGVLPSALQNQ--------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -D---------------------------------------------------------- ----------KDSRN--------------------------------------------- ---------------------------SYDDDST-------------------------- ---------------EVEAQDVRAPAHAAR------------------------------ --------------------------------------AKD------------------- ------------------------------------------------------------ ----------------------AVASLPK-QQM--------------------------- ------ESSMGASAGGDDRSQRGH------------------------------------ ------------------------------------------------------------ ------------------------------------------------ASSP-------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------ARPSR---------------------------------- ------------------------------------------------------------ ----------------P------------------------------------------- -----------------------SG-------------------PQFRARVP-------- -------------------------------------------------------GRAS- -------------P--GKSE-PSKRPL-S------------------------------- ----------KSQQSVSAE----------------EE-EEEDAGIFKGGKE-DLLSSSVR KWPSSST-PRSDKYTDG------------------------------SFAKDERE----- --------------------------------------------------PAIALAP--- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------RGG------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----SL------------------------------------------------------ -------------------APA-------------------------------------- -------------------KRPLPPP-P-------------------------------- ------------------------------------------------------------ ------------------------------G------------------SS--PRASHLP SRPPP-----------RSA----------------------------ATAS--------- ---------------------------------PVSGTHPWPR----------------- --------------YTTRSPPSH------------------------------------- ----SST-T--------------------------------------------------- ------------------------------PML----------SLRQRMMH--------- ----A----------RFRNPL-----SRQ-------------PA---------------- ------------------------------------------------------------ ---------------------------RPSY------R------Q--------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------GYNGRPNV----------- --EGK---VLPGSNGKPNGQRIINGPQGTKWVVDLDRGLVLNAEGRYLQDSHGNPLRIKL GGDGRTIVDLEGTPVVSPDGLPLFGQGRHGTPLASAQDKPILSLGGKPLVGLE--VIKTT THPP-TT-----TTRP---------TTTTTPLP--------T--TTTPRPT-----T--- --------AT-----TRRT--TTT------------------------------------ ---RR-T-TTRR-------PTTTIR--------TTMR-----------------TT--TT ----------TTPKP-------------TT------------------------------ -PIPTCPPGTLERHDDDGNLIM-GSSGIPECY--------------------------A- ------------------------EEDEFSGLETD--------TAVPTEEAYVIYDE--- ---------------------D--------YE-FE-TSR-------P-----P---T--- -------TTEPS-------------------------------------------TTA-- TTPR-----------VIPEEGA----------------------I--------------- -----SSFPEEEFDLAGRKRFV--------------------------APYVTYLNKDPS APCSLTDALDHFQVDSLDEIIPND--LRKSDLPPQHAPRNITVVAMEGCHSFVIVDWDKA APGDVVTGYLVYSASYEDFIRNKWSTQASSVTHLPIENLKPNT----------------- -------------RYYFKVQAQNPHGYGPISPSVSFVTESDNPLLVVRPPG--------- ------GEPIWIPFAFKHDPGYTDCHGRQYVKRTWYRKFVGVVLCNSLRYKIYLSDNL-K -DTFYSIGDSWGRGEDHCQFVDSHLDGRTGPQSYVEALPTIQGYYRQYRQEPVSFGNIGF GTPYYYVGWYECGVSIPGKW---------------------------------------- ------------------------------------------------------ >ENSSBOP00000022274 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------------DHPL------- -----------------------KPRHVKLLSTKMGLKVTWDPPKDATSRPV----EHYN ------------------------------------------------------I-AYGK S-----------------------------------------------LK---------- -----------SLKYIKVNAETYSFLIEDV--------------------------EPGV VYFVLLTAENHS--------GVSRPVYRAESPP--------------------------- -------------------------------------------------------GG--- ---------------------------------EWIKIDGFPIKGPGP------------ ------------------FNETVT------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------DKEVPNKPLRVRVRSS-------------------------------------- -----------------DDRLSVAWKAPRL-SGAKS-------PR-RSRGFLLGYG---- -ESGRKMNY------------VPLTRDERTHEIKKL---ASESV---------------- ---------YVVSLQSMN-----------------SQGRSQPVYRAALTKRKISEE---- ---DELEVPDDISVRVMSSQSVLVSWVDPVLE-KQKKVV--AS-RQYTVRYREKGELARW DYKQITNRRVLIENLIPDTVYEFAVRISQGERDGKWSTSVFQRTPESAPTTAPENLNVWP VSGKPTVVTASWDALPETEGKVKEYILSYAPALKPFGAKSLTYPGDTTSALVDGLQPGER YLFKIRAANRRGLGPHSKAFIVAMPA-----------T-S--KADVQQ--NTEDRGKPEK PE----------------------------------------------RSSPSPRPPA-- -------SP--------------------------------------------------- -------------GRNAKDLLLDLKNKILANGGAPRKPQLRAKKAEEL---DLQS----T EVTG-------KEELGSQEDSPTSPSD-------------TQD----------------- -----------QKRPLRP--PSRHGHSVVAPGRTAVRARMPALPRREGIDK-PGFSAATH --------PL---------------------------------------PGTAPAASA-S PAHHAATQ---------------------------------------------------- -----------------------------GTSHR--------------------P----- ------------------------------------------------------------ ------------------S-----------LPARFNDN---------------------- ----------------------DSVDSDEDELSVASLHPKG------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------------------ASAQ PRPALSPSRLSPSSVLRDRSSVYSGAKPASPA-------------------RNTP----- --------H-------------------------SGAAEEDSSASAP------------- ------PSR---------------------------LSPLRGGSSRLLPTQLHLGP---- -------PLSRGGKDGEDAPATNSN---------------SPSRSATS------------ -----------SSVSSR------------------------------------------- ------------------------------------------------------------ LSSRTQVSE------------------------------------------GAEASDGEG DGDSDMEDSGRQAEATAQTLRT---------R---------------------------- ------------PASGHFHLLRHKPFAANGRAPSRFGIGPGPRLQPSST---PRS---TV PSRAH------------------------------------------------------- --------------------SRVHSHPAS------------------------------- HSRLGSGIHGD--------------------------EEDEKPLP-------------AT ------------------------------------------------------------ ---------------------VVNDH-V------------P-----------------SS S------------------RQPISRGWEALRRSPQRGASLHRKEPIPENP---------- -------------------------------KSA-------------------------- ----------------------------------------------------------GA --------------------------DAHPQGKY-------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------STLSSKAQDVQQS-TDADTEGHSPKAQ PGSTGRHASPARP----------------------------------------------- ---------------------------------------------------SAA------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------RPQH----------------- ------------------------------------------------------------ ---------------------------------------------------HPG-PSVPR RTTPGR--------------------APEQHPHPPVSTSQ-NQP-GPQSRDTGRSPSQPR LAQA-QAGRP---------------------LPTSQ------------------------ ------------------------------------------------------------ ---------------GRSHSFSD------------------------------------- ---------------------------PYT-----------------------------A SS--------------------RGVLPSALQNQ--------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -D---------------------------------------------------------- ----------EDGRG--------------------------------------------- ---------------------------SYDDDST-------------------------- ---------------EVEAQDVRAPAHTAR------------------------------ --------------------------------------AKD------------------- ------------------------------------------------------------ ----------------------AVASLPK-QQM--------------------------- ------ESPTGASAGGDDRSQRQH------------------------------------ ------------------------------------------------------------ ------------------------------------------------ASSP-------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------ARPSR---------------------------------- ------------------------------------------------------------ ----------------P------------------------------------------- -----------------------SG-------------------PQFRARVP-------- -------------------------------------------------------GRAT- -------------P--GKSEPPSKRPLSP------------------------------- ----------KSQQSVSA-----------------EE-EEEDPGIFKGGKE-DLLSSSVR KWPSSST-PRGGKYTDG------------------------------SFAKDERE----- --------------------------------------------------PAIALAP--- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------RGG------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----SL------------------------------------------------------ -------------------APA-------------------------------------- -------------------KRPLLQP-P-------------------------------- ------------------------------------------------------------ ------------------------------G------------------SS--PRASYLP SRPPP-----------RSA----------------------------ATAS--------- --------------------------------PAVAGTHPWPR----------------- --------------YTTRSPPSH------------------------------------- ----SST-T--------------------------------------------------- ------------------------------PML----------SLRQRMMH--------- ----A----------RFRNPL-----SRQ-------------PA---------------- ------------------------------------------------------------ ---------------------------RPSY------R------Q--------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------GYNGRPNV----------- --EGK---VLPGSNGKPNGQRIINGPQGTKWVVDLDRGLVLNAEGRYLQDSHGNPLRIKL GGDGRTIVDLAGTPVVSPDGLPLFGQGRHGTPLASAQDKPILSLGGKPLVGLE--VIKTT THPP-TT-----TTQS---------TTTATPLP--------T--TTTPRPT-----T--- --------AT-----TRRM--TTT------------------------------------ ---RR-T-TTRR-------PTTTIR--------TTMP-----------------TT--TT ----------TTPKP-------------TT------------------------------ -PIPTCPPGTLERHDDDGNLIM-SSSGIPECY--------------------------A- ------------------------EEDEFSGLESD--------TTVPTEEAYVIYDE--- ---------------------D--------YE-FE-TSR-------P-----P---A--- -------TTQPS-------------------------------------------TTA-- TTPR-----------VVPEEGA----------------------I--------------- -----GSFPEEEFDLAGRKRFV--------------------------APYVTYLNKDPS APCSLTDALDHFQVDSLDEIIPND--LRKSDLPPQHAPRNITVVAVEGCHSFVIVDWDKA APGDVVTGYLVYSASYEDFIRNKWSTQASSVTHLPIENLKPNT----------------- -------------RYYFKVQAQNPHGYGPISPSVSFVTESDNPLLVVRPPG--------- ------GEPIWIPFAFKHDPGYTDCHGRQYVKRTWYRKFVGVVLCNSLRYKIYLSDNL-K -DTFYSIGDSWGRGEDHCQFVDSHLDGRTGPQSYVEALPTIQGYYRQYRQEPVSFGNIGF GTPYYYVGWYECGVSIPGKW---------------------------------------- ------------------------------------------------------ >ENSPCOP00000001003 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------------TA-------- ---PESGA---------------------------------------------------- --------------------------GLMTSLRAEVVLGEVDSCTVCIVDHPL------- -----------------------KPRHVKLLSTKMGLKVTWDPPKDATSRPV----EHYN ------------------------------------------------------I-AYGK S-----------------------------------------------LK---------- -----------SLKYIKVNAETYSFLIEDV--------------------------EPGV VYFVLVTAENHS--------GVSRPVYRAESLP--------------------------- -------------------------------------------------------GG--- ---------------------------------EWIKIDGFPIKGPGP------------ ------------------FNETVT------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------EKEVPNKPLRVRVRSS-------------------------------------- -----------------DDRLSVAWKAPRL-SGAKS-------PR-RSRGFLLGYG---- -ENGRKMNY------------VPLTRDERTHEIKKL---ASESV---------------- ---------YVVSLQSMN-----------------SQGRSQPVYRAALTKRKISEE---- ---DELDVPKDITVRVMSSQSVLVAWVDPVLE-KQKKVV--AS-RQYTVRYREKGESARW DYKQITNRRVLIENLIPDTVYEFAVRISQGERDGKWSISVFQRTPESAPTTAPENLNVWP VNGKPTVVTVSWDALPETEGKVKEYILSYAPALKPFGAKSLTYPGDTTSALVDGLQPGER YLFKIRAANRRGLGPHSKAFVVAMPT-----------S-K--SSDVQQ--NTEGNWKPQK PE----------------------------------------------PPSSSPKAAA-- -------SSKHTH-L--------------------------------------------- --------PVSPQDRNVKDPLLDLKNKILANGGLPRKLPLRPKKTEEL---GLQS----T EVTE-------EEELDSLEDPPASPSE-------------SQD----------------- -----------QKRTLRP--PSRHGHSVVASGRA------PVLPRKEGADK-RGSSLTAH --------PR--------------------------------------------SSAA-T PAHHTATQ---------------------------------------------------- -----------------------------GTSHR--------------------P----- ------------------------------------------------------------ ------------------AGG-----SSANPLASSADN---------------------- ----------------------DSVDPDEDERAAGSLHPKD------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------------------TPAQ PWPALSPSRQSASSVLRDRSAMHHGTKPASPA-------------------WRAP----- --------H-------------------------SGAVEEDFSASAP------------- ------PSR---------------------------LSPPHRGSSRLLPTQPHPGP---- -------LPSRGWRDGHEAPAANSN---------------APSRSTMS------------ ------------------------------------------------------------ ------------------------------------------------------------ -SSRTQVSE------------------------------------------GADASDGQG DSDGDAEDSGRPAEATAQTLRA---------R---------------------------- ------------PASGHLSLLRHKPFAANGRFLNRFGSGRGLRLQPSSS---PQS---TV PPRAH------------------------------------------------------- --------------------SRAHSHPAS------------------------------- VPRLGSGIHGD--------------------------GEDEKPLS-------------AT ------------------------------------------------------------ ---------------------VVNDH-V------------P-----------------SS S------------------RQTTSRGWDPLRRSPQRGAGLHRKEPVPENP---------- -------------------------------KSA-------------------------- ----------------------------------------------------------GT --------------------------DVHSQGKS-------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------SSLSSKAQDVQQS-TDVDMEGHSPKTQ PVSLGRQLSSARP----------------------------------------------- ---------------------------------------------------PAA------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------RSQH----------------- ------------------------------------------------------------ ---------------------------------------------------HPA-PSVPR RMTPGR--------------------ASERQPPPPVSTSQ-HQPSAPQSKDSGRSLSQPK LALA-QAGRP---------------------RPTSQ------------------------ ------------------------------------------------------------ ---------------GGAHALSD------------------------------------- ---------------------------PYT-----------------------------A SS--------------------RGVLHTGRRSQ--------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -D---------------------------------------------------------- ----------EDSQS--------------------------------------------- ---------------------------SNDSDSTEVLAPARAKDATLPLPKHSQVESPAG SAEDRPRSGHAGSWP--------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------R---------------------------------- ------------------------------------------------------------ ----------------P------------------------------------------- -----------------------GG-------------------PQTRTRVP-------- -------------------------------------------------------GRAT- -------------P--RETQPPSRRPLPS------------------------------- ----------KSQQSVSAE----------------D--EEEDAGFLKGGKE-DPLSSSVS KWPSTST-PKGSKYADG------------------------------SLAKDQRE----- --------------------------------------------------PAVRSPP--- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------RGK------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----SA------------------------------------------------------ -------------------APG-------------------------------------- -------------------KRPLPLP-P-------------------------------- ------------------------------------------------------------ ------------------------------G------------------SP--PRASHLP PRLPP-----------RSP----------------------------ATAS--------- ---------------------------------PVTGTPSWPR----------------- --------------SATRAPPSY------------------------------------- -----ST-T--------------------------------------------------- ------------------------------PML----------SLRQRMMH--------- ----S----------RFRNPL-----SRQ-------------TG---------------- ------------------------------------------------------------ ---------------------------RPPY------R------Q--------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------GYNGRPNV----------- --EGK---ALPGSNGKPNGQRIINGPQGTKWVVDLDRGLVLNAEGRYLQDSHGNPLRVKL GGDGRTIVDLEGTPVVSPDGLPLFGQGRHGTPLASAQDKPILSLGGKPLVGLE--VIKTT THPP-TT-----TTRP---------TTTTTPLPATTTPRPTT--ATTPRPT-----T--- --------AT-----TRRT--TTT------------------------------------ ---RR-T-TTMR-------PTTTIR--------TTTR-----------------TT--TT ----------TTPEP-------------TT------------------------------ -PVPTCPPGTLQQRDNGGNLIM-GSNGIPECY--------------------------P- ------------------------E-------------------------------EGNL SDSIGA-----PLPGSLHIISD--------YE-FE-TSR-------P-----P---A--- -------TTKPS-------------------------------------------TTAAT TTPK-----------VIPEEGT----------------------I--------------- -----SSFPQEEFDLAGKKRFV--------------------------APYVTYLNKDPS APCSLTDALDHFQVDSLDEIIPND--MRKSDLPPQNAPRNITVVAMEGCHSFVIVDWDKA TQGDVVTGYLVYSASYEDFIRNKWSTQASSMTHLPIENLKPNT----------------- -------------RYYFKVQAKNPHGYGPISPSVSFVTESDNPLLVVRPPG--------- ------GEPIWIPFAFKHDPGYTDCHGRQYVKRTWYRKFVGVVLCNSLRYKIYLSDNL-K -DTFYSIGDSWGRGEDHCQFVDSHLDGRTGPQSYVEALPTIQGYYRQYRQEPVSFGHIGF GTPYYYVGWYECGVSIPGKW---------------------------------------- ------------------------------------------------------ >ENSOGAP00000003392 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------VDSCAVCVVDHPL------- -----------------------KPRHVKLQPTKMGLKVTWDPPKDASSRPV----EHYN ------------------------------------------------------I-AYGK S-----------------------------------------------LK---------- -----------SLKYIKVNAETYSFLIEDV--------------------------EPGV VYFVLVTAENHN--------GVSRPVYRAESLP--------------------------- -------------------------------------------------------GG--- ---------------------------------EWIKIDGFPIKGPGP------------ ------------------FNETVT------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------EKEVPNKPLRVRVRSS-------------------------------------- -----------------DDRLSVAWKAPRL-SGAKS-------PR-RSRGFLLGYG---- -ESGRKMNY------------VPLTRDERTHEIKKL---ASESV---------------- ---------YVVSLQSMN-----------------TQGQSQPVYRAALTKRKISEE---- ---DELDVPKDISVRVMSSQSVLVTWVDPVLE-KQKKVV--AS-RQYTVRHREKGESARW DYKQVTNRRVLIENLIPDTVYEFAVRISQGERDGKWSPSVFQRTPESAPTTAPENLNVWP VNGKPSVVTVSWDALPETEGKVKEYILSYAPALKPFGAKSLTYPGDTTSALVDGLQPGER YLFKIRASNRRGLGPHSKAFVVALPT-----------T-RRSESNVQQ--NTDGHWKPQK PE----------------------------------------------PPSAPPKDSA-- -------SSRHS------------------------------------------------ ---------APPQDRNVKDPLFDLKNKILAKGGVSRKLPPRHKKTEEL---DVQS----I EVTN-------AEEPDSLEDPLALPSG-------------TQG----------------- -----------QRRPLRP--PSRYGLSVVAPGRT------PVLPQRQGEDE-PGSSLVAH --------PR---------------------------------------SGTAPSAAA-S SAHHTATHH--------------------------------------------------- ----------------------------AATSHR--------------------P----- ------------------------------------------------------------ ------------------SGG-----LSANLPASSADN---------------------- ----------------------DSVDPDEDERAAGSLHPKDIS----------------- --------A--------------------------------------------------- -----------------------------------------QQ----------------- --------------PP-------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------PKSRTQTQ---- --PALSPSRQSASSILRDRSAMQHGTKPALPA-------------------RRTP----- --------H-------------------------SGTMEEDLSVSAP------------- ------ASR---------------------------LSPPYRGSSRLLPTQPHPGS---- -------LPSRGWKDGHEALASNIN---------------APSQSTMS------------ ------------------------------------------------------------ ------------------------------------------------------------ -SSKTQVSE------------------------------------------GADTFDGQD DSDNEAEDSRRPAEATAQTLRT---------R---------------------------- ------------PASGHLSLLRHRPFAANGRFPNRFGGGRGPRLQPSSS---PQS---TV PSRAH------------------------------------------------------- --------------------SRGHSHPAS------------------------------- LPRTGSGTHGD--------------------------EEDEKPLS-------------AT ------------------------------------------------------------ ---------------------VVNDH-M------------P-----------------SS S------------------RQHTSRGWDPLKRSPQRGASLLQKEPIPENP---------- -------------------------------KTA-------------------------- ----------------------------------------------------------ET --------------------------GAHSQGKS-------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------SSLSSKEQDLQQS-TDVDMEDLNPPKQ PVSTGRQLSPARP----------------------------------------------- ---------------------------------------------------PTA------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------RSQH----------------- ------------------------------------------------------------ ---------------------------------------------------YPR-PSVPR RITPGR--------------------APESQHPSWVSTSQ-HYPSGSQSKDAGRSLSQPK LALA-QAGRP---------------------RPTSQ------------------------ ------------------------------------------------------------ ---------------GSAHALSD------------------------------------- ---------------------------PHR-----------------------------A SS--------------------RGVLHAARQSQ--------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -D---------------------------------------------------------- ----------EDSQS--------------------------------------------- ---------------------------SEDDNSTGLGAPARAKDATLLLPKHRQVLSPAG SPDHRPQRGHAGSSP--------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------R---------------------------------- ------------------------------------------------------------ ----------------P------------------------------------------- -----------------------GW-------------------PQPRARVP-------- -------------------------------------------------------SRAG- -----------------ETEPPSKRPLPS------------------------------- ----------KSQQSVSAE----------------DDHEEDEEGFLKAGKE-DPLSSPVA KWPSSST-PRGSKYADG------------------------------STAKDKREP---- GTV---PAPR--------------------------GGSPVQESDALGKRPA-------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------G------------------SP--PRASALL PRPPP-----------RSP----------------------------ATAG--------- ---------------------------------PVTATPSWPR----------------- --------------PAARAPPSS------------------------------------- -----SP-T--------------------------------------------------- ------------------------------PML----------SLRQRMMH--------- ----S----------RFRNPL-----SRA-------------PG---------------- ------------------------------------------------------------ ---------------------------RPPH------R------Q--------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------GYNGGPNV----------- --DGK---SLPGGNGKPSGQRIINGPQGTKWVVDLDRGLVLNAEGRYLQDSHGNPLRVKL GGDGRTIVDLGGTPVVSPDGLPLFGQGRHGTPLASAQDKPILSLGGKPLVGLE--VIKTT THPP-TT-----TTRPTTTTTTTTTTTTTTPLP--------T--TTTPRPT-----T--- --------AT-----TRRM--TTT------------------------------------ ---RR-T-ATMR-------PKVN-R--------TTMR-----------------TT--TT ----------TTPEP-------------TT------------------------------ -PIPTCPPGTLEKHDDDGNLIM-GSDGIPECS--------------------------P- ------------------------EEDEFSGLETD--------TATPTEEAYVVYDE--- ---------------------D--------YE-FE-TSR-------P-----P---A--- -------TTKPS-------------------------------------------TTA-- VTPK-----------VIPEEGT----------------------I--------------- -----SSFPEEEFDLAGKKRFI--------------------------APYVTYLNKDPS APCSLTDALDHFQVDSLDEIIPND--LRKSDLPPQNAPRNITVVAVEGCHSFVIVDWDKA TPGDVVTGYLVYSASYEDFIRNKWSTQASSVTHLPIENLKPNT----------------- -------------RYYFKVQAKNPHGYGPVSPSVSFVTESDNPLLVVRPPG--------- ------GEPIWIPFAFKHDPGYTDCHGRQYVKRTWYRKFVGVVLCNSLRYKIYLSDNL-K -DTFYSIGDSWGRGEDHCQFVDSHLDGRTGPQSYVEALPTIQGYYRQYRQEPVSFGHIGF GTPYYYVGWYECGVSIPGKW---------------------------------------- ------------------------------------------------------ >ENSSTOP00000006376 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------------MA-------- ---LECGAPLRAPRP-LSWAA-LLLLAALLPVGSSEA-AP-------------------- ------------------------------------------------VDHPL------- -----------------------KPRHVKLLSTKMGLKVTWDPPKEATSRPV----EHYN ------------------------------------------------------I-AYGK S-----------------------------------------------LK---------- -----------GLRYVKVNAETHSFLIDDV--------------------------EPGV VYFVLVTAENHS--------GVSRPVYRAESLP--------------------------- -------------------------------------------------------GG--- ---------------------------------EWIKIDGPSLKGPAS------------ ------------------FNETIT------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------EKEAPNKPLRVRVRSS-------------------------------------- -----------------DDRLSVAWKAPRL-SGAKS-------PR-RSRGFLLGYG---- -ESGRKMNY------------VPLTRDERTHEIKKL---ASESV---------------- ---------YVVSLQSMN-----------------SQGRSQPVYRAALTKRKISEE---- ---DELDVPKDISVRVMSSQSVLVAWVDPLLE-KQKKVV--AS-RQYTVRYREKGESARW DYKQIANRRVLIESLIPDTVYEFAVRVSQGERDGKWSTSVFQRTPESAPTTAPENLNVWP VNGKPTVVTVSWDALPETEGRVKEYILSYAPALKPFGAKSLTYSGHTTSALVDGLQPGER YLFKIRAANRRGPGPHSKAFIVTMPT-----------S-NTSESDVQQ--NTNDNWKPKK PE----------------------------------------------PSSPSPKDP--- ------------------------------------------------------------ -------------GRNIKDPLLDLKNKILANGGLPRKPQLRPWKTEES---DRQS----T EVTD-------EEELDSLENPPKLPSE-------------TQD----------------- -----------QRRAPRP--PSRSGQWL--PGRTPARARVPLLPRKEGLDK-RGPSLVTH --------PR---------------------------------------PAATPSAES-S PGHHQAPQ---------------------------------------------------- -----------------------------GPSPH--------------------P----- ------------------------------------------------------------ ------------------AGGPSDSSI---------DN---------------------- ----------------------DSVDQDEDKQAEGSLYPKA------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------------------NPAQ ARPALFPSRQGASSILRDRSPVHNGAKPVFPA-------------------RRTP----- --------Q-------------------------SGAMEEDSRAPAP------------- ------PSR---------------------------LSPPHRGSSRLRPTQPHPGP---- -------PLSR------------------------------------------------- ------------------K----------------------DVN---------------- -------------------------------GQESPATNFHASSQSTLSSSDS-----SP LSSRTQVSEEVD---------------------TSDD------------WGG-------- -GDRTTENTGRQAEATTPSLRA---------R---------------------------- ------------PASGPLSLLRNKAFASNGRSSNRLTNGQGPRLQPSTS---PQS---TM ASRVP------------------------------------------------------- --------------------SRGRSQPAS------------------------------- HSRLGSDIHGD--------------------------GEDEKPLP-------------AT ------------------------------------------------------------ ---------------------VDNDL-V------------P-----------------PS S------------------RQPTSRGWDSLRRDPQRGTSLYRKELTPEPP---------- -------------------------------KSA-------------------------- -----------------------------------------------------------T --------------------------DAHPQGKS-------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------SSLSSKAQDVQQS-TDVDTDGHSPKTQ PGFTGRQLSPARP----------------------------------------------- ---------------------------------------------------PAA------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------RSQP----------------- ------------------------------------------------------------ ---------------------------------------------------YPG-SSVPR RTAPDR--------------------TFEKQPPPPVSPAR-HQSPSPQSQDAERSLSQPK LALA-HAGRP---------------------RPTSQ------------------------ ------------------------------------------------------------ ---------------GGAHSISD------------------------------------- ---------------------------PDT-----------------------------A SS--------------------RGGLRPAAQGQ--------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -D---------------------------------------------------------- ----------RDSQS--------------------------------------------- ---------------------------SYEDNST-------------------------- ---------------EVEAPDVQVPPHTAR------------------------------ --------------------------------------TKD------------------- ------------------------------------------------------------ ----------------------ATPSLPKHRQV--------------------------- ------ASSTGT---GDDKPQRGH------------------------------------ ------------------------------------------------------------ ------------------------------------------------SGFT-------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------VRPSR---------------------------------- ------------------------------------------------------------ ----------------P------------------------------------------- -----------------------GG-------------------PHTRARAP-------- -------------------------------------------------------GRAT- -------------P--RKKEPPSKWPLQP------------------------------- ----------KSQQSVSAEE--------------EDE-EEEDAGFLKGGKE-DPLSPSVP KWPYSST-PRGSKHADG------------------------------SLAKD-------- ---------RTAIVPAARGGS------------SHAT----------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------PG-------------------------------------- -------------------KRPPLPP-L-------------------------------- ------------------------------------------------------------ ------------------------------G------------------SP--PRVAHLP TRHPP-----------RGS----------------------------ATPS--------- ---------------------------------PILSTQSWPR----------------- --------------YTTHAPPSY------------------------------------- ----SST-T--------------------------------------------------- ------------------------------PML----------SLRQRMQR--------- ---------------RFRTPV-----ARQ-P-----------PP---------------- ------------------------------------------------------------ ---------------------------RPPQ------V------Q--------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------GYNGRPKV----------- --EEK---VLPGNNGKPNGQRIINGPQGTKWVVDLDRGLVLNAEGRYLQDSQGNPLRVKL GGDGRTIVDLGGTPVVSPDGLPLFGQGRHGKPLASAQDKPILSLGGKPLVGLE--VIKTT TRPS-TT-----TPQP---------TTTTTTVP--------T--TTTTRPT-----T--- --------AT-----TRRT--TTT------------------------------------ ---RR-TITTTR-------PRTIVR--------TTTR-----------------PT--TT T----TTPEPTTPEP-------------TT------------------------------ -PVPTCPPGTLEQHDEDGNLIM-GANRIPECH--------------------------P- ------------------------EEDEFSGL--D--------TEMPTEEAYVVYDE--- ---------------------D--------YE-IE-TTR-------P-----P---A--- -------TTRPS-------------------------------------------TTT-- ---R-----------VIPEEGP----------------------I--------------- -----RSFPQEEFDVAGQKRFV--------------------------APYVTYLSKDPS APCSLTDALDHFQVESLDEIIPND--LRKNDLPPQHAPRNITVVAMEGCHSFVIVDWDKA TPGDVVTGYLVYSASYEDFIRNKWSTQASSVTHLPIENLKPNT----------------- -------------RYYFKVQAKNPHGYGPISPSVSFVTESDNPLLVVRPPG--------- ------GEPIWIPFAFKHDPGYTDCHGRQYVKRTWYRKFVGVVLCNSLRYKIYLSDNL-K -DTFYSIGDSWGRGEDHCQFVDSHLDGRTGPQSYVEALPTIQGYYRQYRQEPVSFGQIGF GTPYYYVGWYECGVSIPGKW---------------------------------------- ------------------------------------------------------ >ENSCLAP00000011106 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------MGLKVTWDPPKDATSRPV----EHYN ------------------------------------------------------I-AYGK S-----------------------------------------------LK---------- -----------SLKYIKVNAETYSFLIQDV------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------EKEVPNKPLRVRVRSS-------------------------------------- -----------------DDRLSVAWKAPRL-SGAKS-------PR-RSRGFLLGYG---- -ESGRKMNY------------VPLTRDQRTHEIKKL---ASESV---------------- ---------YVVSLQSMN-----------------SQGQSQPVYRAALTKRKISEE---- ---DELDVPKDISVRVMSSQSVLVAWVDPVLE-KQKKVV--AS-RQYTVRYREKGESARW DYKQIGNRRVMIENLMPDTVYEFAVRISQGERDGKWSTSVFQRTPESAPTTAPENLNVWP VNGKPTVVTVSWDPLPETEGKVKEYILSYAPALKPFGAKSLTYSGHTTSALVDGLQPGER YLFKIRAANRRGPGPHSKAFIVAMPA-----------T-STSEPKVQQ--NTEDHWKAEK PE----------------------------------------------PSSPPPKAPA-- -------SSEHTQ----------------------------------------------- ------------LRRNIKDPLLDLKNKILANGGMLRKPQLRPKKAEEL---DTRS----M EVTD-------EEEQDSLEDPRTSNSD-------------TQD----------------- -----------QRQTLRQ--PSRSGHRVPAPGRTPLRARMPVLSPKEGMDR-R------- ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------GPSPH--------------------P----- ------------------------------------------------------------ ------------------SGDRSASSI---------DN---------------------- ----------------------DSVDRDEEERT--------------------------- --------ARL------------------------------------PHSK--------- ---------VAASQQLSPKTPAQFQPSRSPSNEAASSDTRST------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------HHGAKPALSA-------------------GRTP----- --------H-------------------------SGAVNEDSSAPAP------------- ------PSR---------------------------LSPPLRGSSRLLPIQPHPRP---- -------PLSR------------------------------------------------- -------------VSAH------------------------------------------- ------------------------------------------------------------ LSSRTEVSE------------------------------------------GGDTSDGRD HSDRDAKDAGREAEATVPSPRA---------R---------------------------- ------------PASGHFSLLRNRPFAANGRFPNRFFNGRGPQVQPSSS---PQS---TL ASRVL------------------------------------------------------- --------------------PRVHSQSAP------------------------------- HPRLGSGIHGD--------------------------VEAEKPLP-------------AT ------------------------------------------------------------ ---------------------VVNDH-R------------T-----------------SS P------------------RQPPSGGWDSSRRGPQRGASLYRKEPVPENP---------- -------------------------------KSA-------------------------- ----------------------------------------------------------GT --------------------------DVHPLDKS-------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------PSLTSRAQDVQQG-TDLEVEE-----Q LVSTGRQLSPARP----------------------------------------------- ---------------------------------------------------PAS------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------KTQP----------------- ------------------------------------------------------------ ---------------------------------------------------YPG-ASVSR RIAPGR--------------------APQNQP---------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------L-------------------------------------------- -------------------APVSSQPGSYEDNST-------------------------- ---------------EVEATDARDPTHTAR------------------------------ --------------------------------------SKD------------------- ------------------------------------------------------------ ----------------------ATPSLSKYHQV--------------------------- ------ASPVGP---GEDRPQRGH------------------------------------ ------------------------------------------------------------ ------------------------------------------------AGAS-------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------PRPSR---------------------------------- ------------------------------------------------------------ ----------------P------------------------------------------- -----------------------SS-------------------SQPRARVP-------- -------------------------------------------------------GMAG- ---------AQVTP--GK-ESPSKWPLPS------------------------------- ----------KSLQSVST-----------------ED-EEEDAGFLKGGKE-DPLSASVP KWPSSST-PRGSKYSDGKN----------SAQEE------TSHLPTRR------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---PP-----------DSP----------------------------ATRS--------- ---------------------------------PIVSTSSWQQ----------------- --------------YTTRAPASY------------------------------------- ----YST-T--------------------------------------------------- ------------------------------PML----------SLRQRMQR--------- ---------------RFRI----------------------------------------- ------------------------------------------------------------ --------------------------------------------T--------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------GYNGRLNG----------- --EGK---VLPGSNGKPSGQRIINGPQGTKWVVDFDRGLVLNAEGRYLQDSHGNPLRVKL GGDGRTIVDLGGTPVISPDGLPLFGQGRHGKPLANAPDKPILSLGGKPLVGLE--VIKTT TLPP-TT-----TTWP---------TTATTTVA--------T------------------ ---------TRRTTTTRRM--TTT------------------------------------ ---QRMT-TTTR-------PTTTVR--------TTMR-----------------TT--TT ----------TTPEP-------------TT------------------------------ -PIPTCPPGTLGHLDDDGNLIM-GSNGIPECY--------------------------P- ------------------------EEDEFSGLETD--------TAIPTEEAY-------- --------------------------------------------------------PTTK PTTK--PTTKPT-------------------------------------------TAA-- ATPK-----------VIPEEGS----------------------I--------------- -----SSFPEEEFDLAGRKRFV--------------------------APYVTYLNKDPS APCSLTDALDHFQVETLDEIIPND--LRKSDLPPQHVPRNITVVAMEGCHSFVIVDWDRA APGDVVTGYLVYSASYEDFIRNKWSTQASSVTHLPIENLKPNT----------------- -------------RYYFKVQAKNPHGYGPISSSVSFVTESDNPLLVVRPPG--------- ------GEPIWIPFAFKHDPGYTDCHGRQYVKRTWYKKFVGVTLCNSLRYKIYLSDNL-K -DTFYSIGDSWGRGEDHCQFVDSHLDGRTGPQSYIEGLPKIQGYYRQYRQEPVSFGHIGF GTPYYYVGWYECGVSIPGKW---------------------------------------- ------------------------------------------------------ >ENSODEP00000010154 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------MGLKVTWDPPKDATSRPV----EHYN ------------------------------------------------------I-AYGK S-----------------------------------------------LK---------- -----------SLKYIKVNAETYSFLIEDV------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------EKEVPNKPLRVRVRSS-------------------------------------- -----------------DDRLSVAWKAPRL-SGAKS-------PR-RSRGFLLGYG---- -ESGRKMNY------------VPLTRDQRTHEIKKL---ASESV---------------- ---------YVVSLQSMN-----------------SQGQSQPVYRAALTKRKISEE---- ---DELDVPKDISVRVMSSQSVLVAWVDPVLE-KQKKVV--AS-RQYTVRYREKGESARW DYKQIGNRRVMIENLMPDTVYEFAVRISQGERDGKWSTSVFQRTPESAPTTAPENLNVWP VNGKPNVVTVSWDPLPETEGKVKEYILSYAPALKPFGAKSLTYSGHTTSALVDGLQPGER YLFKIRAANRRGPGPHSKAFVI---------------------PTVQQ--NTENHWKSEK PE----------------------------------------------PSSPSPKTPA-- -------FSEHTQ----------------------------------------------- ------------LK--VKDPLLDLKNKILANGGMPRKPQLHPKKAEEL---DARS----T EVTD-------EEE---------------------------------------------- ------------RRTLRQ--PSRTGHRVPVPGRTPLRSRMPVSPPKEGMDR-HV------ ------------------------------------------------------------ -------LPPVEAS-----------RDL-------------------------------- -----------------SPY------HNGGP----------------------------- ------------------------------------------------------------ ----------------------SASSI---------DN---------------------- ----------------------DSVDRDEEERA--------------------------- --------AGF------------------------------------PHSK--------- ---------SAAFQQLSPKTSAQFQPSLSHSNEAASSDTRPM------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------HHGTNPALPA-------------------GRTP----- --------H-------------------------SGVMEEDSS----------------- ---------------------------------------------------PHPGP---- -------PLSRGWKDGR-SPAVNSH---------------SPSRSTLS------------ -----------APVSSH------------------------------------------- ------------------------------------------------------------ LSSRTEVSE------------------------------------------GGDTADGGS HSDRNAGDTRWKAEATVPSPRA---------R---------------------------- ------------PASGHFSLLRNRPFAANGRFPNRFFNGQGSRVQPSSS---PQS---TL ASRVL------------------------------------------------------- --------------------SRGNSQSTS------------------------------- HPRLGSDIHGH--------------------------VEAEKPLP-------------AT ------------------------------------------------------------ ---------------------VVNDH-R------------T-----------------AS P------------------RQHPSGGWDSSRRGSQRGASLYRKEPVPENP---------- -------------------------------KSA-------------------------- ----------------------------------------------------------GT --------------------------DVHPLDKS-------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------PSLTSRTQDVQQS-TDLEVEEHFPKTQ LVSAGRQLSPARP----------------------------------------------- ---------------------------------------------------SAA------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------KTQP----------------- ------------------------------------------------------------ ---------------------------------------------------YPG-ASIPR RMAPGR--------------------VPHNQPS--VSSSQHRHPSSSQSKDPDRSLSQPK LALA-P------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -D---------------------------------------------------------- ----------KDSQS--------------------------------------------- ---------------------------SYEDNST-------------------------- ---------------EVEALDVGDPTHTVG------------------------------ --------------------------------------SKD------------------- ------------------------------------------------------------ ----------------------ATPSLTKYHQV--------------------------- ------ASPVGT---GEERPQRGH------------------------------------ ------------------------------------------------------------ ------------------------------------------------AGTS-------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------SRPNR---------------------------------- ------------------------------------------------------------ ----------------PGTPDLRPRVPGRT------------------------------ ---------------------EG------------------------------------- ------------------------------------------------------------ ----------QVTP--GK-KSPSKRPLPS------------------------------- ----------KSLQSVSTEE--------------EEE-EEEDVGFLKGGQE-DPLSSSVP KRPSSSI-PRGSKYSDG------------------------------RLTKD-------- ---------RPAIVLSS------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------P-------------------------------- ------------------------------------------------------------ ------------------------------G------------------SS--PRASQLP TGHPP-----------RSP----------------------------ATQS--------- ---------------------------------PIVSTSSWPQ----------------- --------------YTTRAPPSY------------------------------------- ----YST-T--------------------------------------------------- ------------------------------PML----------SLRQRMQR--------- ---------------RFRIPG-----SRQ-------------PA---------------- ------------------------------------------------------------ ---------------------------RPSY------A------Q--------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------GYNGRPNG----------- --EGK---VLPGSNGKPSGQRIINGPQGTKWVVDFDRGLVLNAEGRYLQDSHGNPLRVKL GGDGRTIVDLGGTPVISPDGLPLFGQGRHGKPLASAPDKPILSLGGKPLVGLE--VIKTT TLPP-TT-----TTLP---------TTTTTIAP--------T--TTTPRPT-----R--- --------ATRRTTSTRSM--TTT------------------------------------ ---HRMT-TTAR-------PTTTIR--------TTMR-----------------TTTITT ----------TTPEP-------------TT------------------------------ -PIPTCPPGTLGHLDDDGNLIM-SSNGIPECY--------------------------P- ------------------------EEDEFSGLEMD--------TATPTEEDY-------- ------------------------------------------------------------ LTTR--PTTKPT-------------------------------------------TAV-- AMPK-----------VIPEEGP----------------------I--------------- -----NSFPEEEFDMAGKKRFV--------------------------APYVTYLNKDPS APCSLTDALDHFQVETLDEIIPND--LRKNDLPPQSAPRNITVVAMEGCHSFVIVDWDKA TPGDVVTGYLVYSASYEDFIRNKWSTQASSVTHLPIENLKPNT----------------- -------------RYYFKVQAKNPHGYGPISSSVSFVTESDNPLLVVRPPG--------- ------GEPIWIPFAFKHDPGYTDCHGRQYVKRTWYKKFVGVILCNSLRYKIYLSDNL-K -DTFYSIGDSWGRGEDHCQFVDSHLDGRTGPQSYIEGLPKIQGYYRQYRQEPVSFGHIGF GTPYYYVGWYECGVSIPGKW---------------------------------------- ------------------------------------------------------ >ENSCPOP00000005806 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------MGLK-------------------HYN ------------------------------------------------------I-AHGR S-----------------------------------------------LK---------- -----------SRRHIKVNAETYSFLIEDV------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------EKEVPNKPLRVRVRSS-------------------------------------- -----------------DDRLSIAWKAPRL-SGAKS-------PR-RSRGFLLGYG---- -ENGRKMNY------------VPLTRDQRTHEIKKL---ASESV---------------- ---------YVVSLQSMN-----------------SHGQSQPVYRAALTKRKISEE---- ---DELDVPKDISVRVMSSQSVLVAWVDPAVE-KQKKVV--AS-RQYTVRYREKGESARW DYKQIGHRRVMIENLMPDTVYEFAVRISQGERDGKWSTSVFQRTPESAPTTAPENLNVWP VNGKPTVVTVSWDPLPETEGKVKEYILSYAPALKPFGAKSLTYSGHTTSALVDGLQPGER YLFKIRAANRRGPGPHSKAFVVAMPT-----------T-STIEPKVQQ--NTEDRWKSEK PE----------------------------------------------PSSPSPKAPA-- -------SSEHTH-F--------------------------------------------- --------PDSLLGRNVKDPLLDLKNKILANGGMPRKPQLHPKKAEEL---DAQS----V EVTD-------EEEQDSLENPHTANSD-------------AQD----------------- -----------QRRISRL--PSRSGHWIPAPGKPPLRAR-PVLPPKEGMGR-RVPSRIAN --------PR---------------------------------------PGATSSEEA-S PAHHAATQ---------------------------------------------------- -----------------------------GPSPHSKE----------------GP----- ------------------------------------------------------------ ----------------------SVSSI---------DN---------------------- ----------------------DSVDQDEEEQA--------------------------- --------TTF------------------------------------PHSK--------- ---------ATVSQKLPPKTSSQFRPSLSSSSEATSSDTR-------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------LSPPLRGSSRLLPIQPHPGP---- -------PLSRGWKDGH-SQTANSH---------------TPSKSTVS------------ -----------APVSSH------------------------------------------- ------------------------------------------------------------ LSSRTQVSE------------------------------------------EGDTSDGRD HRDRDLEDPGRETEATVHSQRV---------R---------------------------- ------------PASGHIGLLRNRPFAANGRFPNRFSNGRGPRVQPSSS---PQS---TS ASRVL------------------------------------------------------- --------------------PRVHSQSTP------------------------------- HPRLGSGIHED--------------------------GETEKPLP-------------AT ------------------------------------------------------------ ---------------------VVNDH-R------------T-----------------SS P------------------RQPLSGGWDSSRRSPQKGASLYRKEPVPEHP---------- -------------------------------KSA-------------------------- ----------------------------------------------------------GT --------------------------DVHPLDKS-------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------PSLTPRAQD-----------EHFPKTQ LVSTGRQLSPPRP----------------------------------------------- ---------------------------------------------------PVA------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------RTQP----------------- ------------------------------------------------------------ ---------------------------------------------------YPG-INVPR RMAPG------------------------------------RHSGSPQSQDADRSLSQPK LALA-PAGRPPGSSGEV-------------LRPARQ------------------------ ------------------------------------------------------------ ---------------G-------------------------------------------- ------------------------------------------------------------ --------------------------------Q--------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -D---------------------------------------------------------- ----------KDSQS--------------------------------------------- ---------------------------RYEDNST-------------------------- ---------------EVEAPDVQDPMHTSR------------------------------ --------------------------------------AKD------------------- ------------------------------------------------------------ ----------------------ATPSLSKYHQV--------------------------- ------ASPAGT---GEERPQRGH------------------------------------ ------------------------------------------------------------ ------------------------------------------------AGAS-------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------PRSSR---------------------------------- ------------------------------------------------------------ ----------------P------------------------------------------- -----------------------GN-------------------SQPRTRIP-------- -------------------------------------------------------GRAG- ---------VQAIP--GK-QSAYKRPLPS------------------------------- ----------KSLQSVST-----------------EE-EEEDAEFLKGGKE-DPLSSSVP KWSSSST-PRGSKYPDG------------------------------TLTKD-------- ---------RTAI----------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------------SSALPRASHLP TRHPP-----------RSP----------------------------ATQS--------- ---------------------------------SILSTSSWPQ----------------- --------------YTTRAPPSY------------------------------------- ----YST-T--------------------------------------------------- ------------------------------PML----------SLRQRMQR--------- ---------------RFRIPG-----SRQ-DS---PP--NPLAS---------------- ------------------------------------------------------------ ---------------------------R-------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------YNGRPNV----------- --EGK---VLTGSNGKPNGQRIINGPQGTKWVVDFDRGLVLNAEGRYLQDSHGNPLRVKL GGDGRTIVDLGGTPVISPDGLPLFGQGRHGKPLASAPEKPILSLGGKPLVGLE--VIKTT TLPP-TT-----TMRS---------TTTTTIAP--------T--TTTPRPT-----R--- --------AT-----TRRM--TIT------------------------------------ ---RRVT-TTTR-------PTTTIR--------TTMR-----------------TT--TT ----------TTPEP-------------TT------------------------------ -PIPTCPPGMLGHLDDGGNLIM-GSNGIPECY--------------------------P- ------------------------EEDEFSGMETD--------TAIPTEEPYVIYDE--- ---------------------D--------YE-FE-STR-------P-----P---TTTK PTTT--PTTTPT-------------------------------------------T---- ------------------------------------------------------------ -----TSFPEEEFDMAGKKRFV--------------------------APYVTYLNKDPS APCSLTDALDHFQVDTLDEIIPND--LRKSDLPPQHVPRNITVVAMEGCHSFVIVDWDKA TPGDVVTGYLVYSASYEDFIRNKWSTQASTVTHLPIENLKPNT----------------- -------------RYYFKVQAKNPHGYGPMSSSVSFVTESDNPLLVVRPPG--------- ------GEPIWIPFAFKHDPGYTDCHGRQYVKRTWYKKFVGVVLCNSLRYKIYLSDNL-K -DTFYSIGDSWGRGEDHCQFVDSHLDGRTGPQSYIEGLPKIPGYYRQYRQEPVSFGHIGF GTPYYYVGWYECGVSIPGKW---------------------------------------- ------------------------------------------------------ >ENSCAFP00000052761 -----------------------------------------M------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------------A-------- ---PEAGAAPRARCP-LPWAA-LLLLAALLPVVSPAG-AP-------------------- ------------------------------------------------ADHPL------- -----------------------KPRHVKLLSTKMGLKVTWDPPKDATSRPV----EHYN ------------------------------------------------------I-AYGK S-----------------------------------------------LK---------- -----------SLKYIKVNAETHSFLIEDV--------------------------EPGV VYFVLVTAENHN--------GVSRPVYRAESPP--------------------------- -------------------------------------------------------GG--- ---------------------------------EWIQIDGFPIKGPGP------------ ------------------FNETVT------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------EKEVPNKPLRVRVRSS-------------------------------------- -----------------DDRLSVAWKAPRL-SGAKS-------PR-RSRGFLLGYG---- -ESGRKMNY------------VPLTRDERTHEIKKL---ASESV---------------- ---------YVVSLQSMN-----------------SQGQSQPVYRAALTKRKISEE---- ---DELDVPEDINVRVMSSQSVLVAWVDPVLE-KQKKVV--AS-RQYTVRYREKGELARW DHKQTSNRRVLVENLIPDTMYEFAVRISQGERDGKWSTSVFQRTPESAPTTAPENLNVWP VNGKPTAVTVAWDALPETEGKVKEYILSYAPALKPFGAKSLTYPGETTSALVDGLQPGER YLFKIRAANRRGLGPHSKAFIVTIPT-----------T-SSGESDVQQKTHPEDNWKSKK PE-------------------------------------------------TSPKAPT-- -------SSKHTH-L--------------------------------------------- --------PVSPRGRNVKNPLLDLKNKILANGGVPRKPQLHPKKTEGL---DLQS----T EITD-------EEEPDSRGDPPTLPSE-------------TQD----------------- -----------QKPQQRL--PSRSVPSVLAPGRTPVRVQTPGLPRKEGIDR-GSSSLASY --------PR---------------------------------------PGVSPSAPA-S -------------SAPHIRMEGSPRR---------------------------------- ------------------------------------------------------P----- ------------------------------------------------------------ ------------------SAGPS-----TNPPPSSTDN---------------------- ----------------------DSVGQEEEEPAAGSRDPKD------------------- ------------------------------------------------------------ ----------AASQRLPPK----------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------------STSHA----- -RPALWPSRQATSSALRDRSPVHHGTKPALPA-------------------RRAP----- --------H-------------------------LGDREDNSGASVP------------- ------PSR---------------------------LSPPQGGSSRLPPTEPHRGA---- -------PLSRGWKDGYGAAAAKSN---------------VPSQ---------------- ---------SRSSSSSG------------------------------------------- ------------------------------------------------------------ LSSRTQGSE------------------------------------------GEDAS--DG DGDNDTEDRGRQAEATAPTSRA---------RLPA------------------------- ----------GSPVSGHFNLFRNKPFAAHTRYPSRFGSGRGPRLHPSSS---PPS---TV SPRVH------------------------------------------------------- --------------------SRVNS----------------------------------- --------HGVAAE---------------------SEAEDEKPLP-------------AT ------------------------------------------------------------ ---------------------VVNDH-V------------S-----------------SS S------------------RQPASLAVDHLRKGPQRGASLQQKEPLAENP---------- -------------------------------KSA-------------------------- ----------------------------------------------------------GP V------------------------AGAHPQGK--------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------PLPAKALDVQQS-TEVGAEGGYPKAH -------LAPARR----------------------------------------------- ---------------------------------------------------PAT------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------RSQH----------------- ------------------------------------------------------------ ---------------------------------------------------HPG-PGVPK RMAPGQG---LG----------AGAAAPEGQPSPAVSASQ-PQPRGPQSKDVGRPLSKPK PELP-QAARP---------------------HPRAQDSASFSDPYAARGSES-------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------PHA-----------------------------A SS--------------------RGVLPTSPHSR--------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -D---------------------------------------------------------- ----------EDPEAR-------------------------------------------- --SVGKHHDSVEAEARG------------------------------------------- ---------------------AREPAHPAR------------------------------ --------------------------------------ARD------------------- ------------------------------------------------------------ ----------------------PTLSLPKHRQPEAPAGGAGDSHLRR----------PPG SLL--------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------R---------------------------------- ------------------------------------------------------------ ----------------PGGPRPHPVA---------------------------------- -----------------------------------------------RPRVP-------- -------------------------------------------------------GRAGP QAAGKSERASQGAPS-------KKEPLTA------------------------------- ----------KSQQSVSAEE------------------EGEGTMFFKGGKDGDPLSSSAP KWP-SSS-PRGSKYVDG------------------------------NIAKDKTD----- --------------------------------------------------PALVLAPPRV ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------------S PPQ--------------------------------------------------------- ----------------------EE------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------KRAPPPA-P-------------------------------- ------------------------------------------------------------ ------------------------------G------------------SS--PRAPLAP PRHPH-----------RSP----------------------------ATPS--------- ---------------------------------PTVGTPARVR----------------- --------------YTTRAPPVH------------------------------------- ----AST-T--------------------------------------------------- ------------------------------PML----------SLRQRMMN--------- ----S----------RFRNPL-----SRQ-------------PA---------------- ------------------------------------------------------------ ---------------------------RSPT------R------Q--------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------GYNGSPNV----------- --EGK---VLPGSNGKPSGQRIINGPQGTKWVVDLDRGLVLNAEGRYLQDSQGNPLRIKL GGDGRTIVDLGGTPVVSPDGLPLFGQGRHGKPLASAQDKPILSLGGKPLVGLE--VVKTT NRAP-IT-----TTRP-------------------------T--TTTPRPT-----T--- --------AT-----TRRT----------------------------------------- ------T-TTTR-------PTTTIR--------TTTQ------------TTTTTTT--TT ----------TTPEP-------------TT------------------------------ -PTPTCPPGTLERHDEDGNLIT-GSSGLPECY--------------------------P- ------------------------EEDDFSGLETD--------TAMPTEEAYVIYDE--- ---------------------D--------YE-FE-TSR-------P-----P---T--- -------TTRPS-------------------------------------------TTA-- AVPE-----------VIPVEGS----------------------I--------------- -----SSFPGEEFDLAGKKRFV--------------------------APYVTYLSKDPS APCSLTDALDHFQVDSLDEIIPND--MRKSDLAPQHPPRNITVVAVEGCHSFVIVDWDKA TPGDVVTGYLVYSASYEDFIRNKWSTQASSVTHLPIENLKPNT----------------- -------------RYYFKVQAKNPHGYGPISPSVSFVTESDNPLLVVRPPG--------- ------GEPIWIPFAFKHDPSYTDCHGRQYVKRTWYRKFVGVVLCNSLRYKIYLSDNL-K -DTFYSIGDSWGRGEDHCQFVDSHLDGRTGPQSYVEALPTIQ------------------ --------------------DLALTWLLSITCILLCFHDRGHSFGPEQRRYLISMLPGRM ATSASIARSRSALATSGLELPTTMWAGMSVGSPFQGSGNHGTIVPRARPSNPLD >ENSCAFP00020022412 -----------------------------------------MS----------------- --------------------------------------LL-------------------- --------------------------------EKSFGHRFCHRNANAPERAPLDSCAVC- ------------------------------------------------------------ --------------------------------------------------IA-------- ------------------------------------------------------------ -------------------------------------------------DHPL------- -----------------------KPRHVKLLSTKMGLKVTWDPPKDATSRPV----EHYN ------------------------------------------------------I-AYGK S-----------------------------------------------LK---------- -----------SLKYIKVNAETHSFLIEDV--------------------------EPGV VYFVLVTAENHN--------GVSRPVYRAESPP--------------------------- -------------------------------------------------------GG--- ---------------------------------EWIQIDGFPIKGPGP------------ ------------------FNETVT------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------EKEVPNKPLRVRVRSS-------------------------------------- -----------------DDRLSVAWKAPRL-SGAKS-------PR-RSRGFLLGYG---- -ESGRKMNY------------VPLTRDERTHEIKKL---ASESV---------------- ---------YVVSLQSMN-----------------SQGQSQPVYRAALTKRKISEE---- ---DELDVPEDINVRVMSSQSVLVAWVDPVLE-KQKKVV--AS-RQYTVRYREKGELARW DHKQTSNRRVLVENLIPDTMYEFAVRISQGERDGKWSTSVFQRTPESAPTTAPENLNVWP VNGKPTAVTVAWDALPETEGKVKEYILSYAPALKPFGAKSLTYPGETTSALVDGLQPGER YLFKIRAANRRGLGPHSKAFIVAIPTS-----KHHVF----------QKTHPEDNWKSKK PE-------------------------------------------------TSPKAPT-- -------SSKHTH-L--------------------------------------------- --------PVSPRGRNVKNPLLDLKNKILANGGVPRKPQLHPKKTEGL---DLQS----T EITD-------EEEPDSRGDPPTLPSE-------------TQD----------------- -----------QKPQQRL--PSRSVPSVLAPGRTPVRVQTPGLPRKEGIDR-GSSSLASY --------PR---------------------------------------PGVSPSAPA-S -------------SAPHIRMEGSPRR---------------------------------- ------------------------------------------------------P----- ------------------------------------------------------------ ------------------SAGPS-----TNPPPSSTDN---------------------- ----------------------DSVGQEEEEPAAGSRDPKD------------------- ------------------------------------------------------------ ----------AASQRLPPK----------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------------STSHA----- -RPALWPSRQATSSALRDRSPVHHGTKPALPA-------------------RRAP----- --------H-------------------------LGDREDNSGASVP------------- ------PSR---------------------------LSPPQGGSSRLPPTEPHRGA---- -------PLSRGWKDGYGAAAAKSN---------------VPSQ---------------- ---------SRSSSSSG------------------------------------------- ------------------------------------------------------------ LSSRTQGSE------------------------------------------GEDAS--DG DGDNDTEDRGRQAEATAPTSRA---------RLPA------------------------- ----------GSPVSGHFNLFRNKPFAAHTRYPSRFGSGRGPRLHPSSS---PPS---TV SPRVH------------------------------------------------------- --------------------SRVNS----------------------------------- --------HGVAAE---------------------SEAEDEKPLP-------------AT ------------------------------------------------------------ ---------------------VVNDH-V------------S-----------------SS S------------------RQPASLAVDHLRKGPQRGASLQQKEPLAENP---------- -------------------------------KST-------------------------- ----------------------------------------------------------GP V------------------------AGAHPQGK--------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------PLPAKALDVQQS-TEVGAEGGYPKAH -------LAPARR----------------------------------------------- ---------------------------------------------------PAT------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------RSQH----------------- ------------------------------------------------------------ ---------------------------------------------------HPG-PGVPK RMAPGQG---LG----------AGAAAPEGQPSPAVSASQ-PQPRGPQSKDVGRPLSKPK PELP-QAARP---------------------HPRAQDSASFSDPYAARGSES-------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------PHA-----------------------------A SS--------------------RGVLPTSPHSR--------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -D---------------------------------------------------------- ----------EDPEAR-------------------------------------------- --SVGKHHDSVEAEARG------------------------------------------- ---------------------AREPAHPAR------------------------------ --------------------------------------ARD------------------- ------------------------------------------------------------ ----------------------PTLSLPKHRQPEAPAGGAGDSHLRR----------PPG SLL--------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------R---------------------------------- ------------------------------------------------------------ ----------------PGGPRPHPVA---------------------------------- -----------------------------------------------RPRVP-------- -------------------------------------------------------GRAGP QAAGKSERASQGAPS-------KKEPLTA------------------------------- ----------KSQQSVSAEE------------------EGEGTMFFKGGKDGDPLSSSAP KWP-SSS-PRGSKYVDG------------------------------NIAKDKTD----- --------------------------------------------------PALVLAPPRV ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------------S PPQ--------------------------------------------------------- ----------------------EE------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------KRAPPPA-P-------------------------------- ------------------------------------------------------------ ------------------------------G------------------SS--PRAPLAP PRHPH-----------RSP----------------------------ATPS--------- ---------------------------------PTVGTPARVR----------------- --------------YTTRAPPVH------------------------------------- ----AST-T--------------------------------------------------- ------------------------------PML----------SLRQRMMN--------- ----S----------RFRNPL-----SRQ-------------PA---------------- ------------------------------------------------------------ ---------------------------RSPT------R------Q--------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------GYNGSPNV----------- --EGK---VLPGSNGKPSGQRIINGPQGTKWVVDLDRGLVLNAEGRYLQDSQGNPLRIKL GGDGRTIVDLGGTPVVSPDGLPLFGQGRHGKPLASAQDKPILSLGGKPLVGLE--VVKTT TRAP-IT-----TTRP-------------------------T--TTTPRPT-----T--- --------AT-----TRRT----------------------------------------- ------T-TTTR-------PTTTIR--------TTTQT-----------TTTTTTT--TT ----------TTPEP-------------TT------------------------------ -PTPTCPPGTLERHDEDGNLIT-GSSGLPECY--------------------------P- ------------------------EEDDFSGLETD--------TAMPTEEAYVIYDE--- ---------------------D--------YE-FE-TSR-------P-----P---T--- -------TTRPS-------------------------------------------TTA-- AVPE-----------VIPVEGS----------------------I--------------- -----SSFPGEEFDLAGKKRFV--------------------------APYVTYLSKDPS APCSLTDALDHFQVDSLDEIIPND--MRKSDLAPQHPPRNITVVAVEGCHSFVIVDWDKA TPGDVVTGYLVYSASYEDFIRNKWSTQASSVTHLPIENLKPNT----------------- -------------RYYFKVQAKNPHGYGPISPSVSFVTESDNPLLVVRPPG--------- ------GEPIWIPFAFKHDPSYTDCHGRQYVKRTWYRKFVGVVLCNSLRYKIYLSDNL-K -DTFYSIGDSWGRGEDHCQFVDSHLDGRTGPQSYVEALPTIQGYFRQYRQEPVSFGNIGF GTPYYYVGWYECGVSIPGKW---------------------------------------- ------------------------------------------------------ >ENSAMEP00000003767 ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------VDSCAVC- ------------------------------------------------------------ --------------------------------------------------IA-------- ------------------------------------------------------------ -------------------------------------------------DHPL------- -----------------------KPRHVKLLSTKMGLKVTWDPPKDATSRPV----EHYN ------------------------------------------------------I-AYGK S-----------------------------------------------LK---------- -----------SLKYIKVNAETHSFLIEDV--------------------------EPGV VYFVLVTAENHN--------GVSRPVYRAESPP--------------------------- -------------------------------------------------------GG--- ---------------------------------EWIQIDGFPIKGPGP------------ ------------------FNETVT------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------EKEVPNKPLRVRVRSS-------------------------------------- -----------------DDRLSVAWKAPRL-SGAKS-------PR-RSRGFLLGYG---- -ESGRKMNY------------VPLTRDERTHEIKKL---ASESV---------------- ---------YVVSLQSMN-----------------SQGQSQPVYRAALTKRKISEE---- ---DELDMPEDINVRVMSSQSVLVAWVDPVLE-KQKKVA--AS-RQYTVRYREKGELARW DHKQTSNRRVLVENLIPDTMYEFAVRISQGERDGKWSTSVFQRTPESAPTTAPENLNVWP VNGKPTAVTVAWDALPETEGKVKEYILSYAPALKPFGAKSFTYPGETTSALVDGLQPGER YLFKIRAANRRGLGPHSKAFIVTMPT-----------T-GSGESDVQRKTHPEDGWKSEK PE-------------------------------------------------TSPKAPA-- -------SSKHTH-L--------------------------------------------- --------PVSPRGRNVKDPLLDLKNKILANGGVPRKPQFHPKKTEGL---GLQS----T EITD-------EEELDSPGDPPTLPSE-------------TQD----------------- -----------QKPQQRL--PSRSVPPVLTLGRTPVRPQTPVLSRKEGADR-GGSSLASH --------PR---------------------------------------PGVS------S -------------SVPPRRIEGSPHR---------------------------------- ------------------------------------------------------P----- ------------------------------------------------------------ ------------------SGGPS-----TNLPPSSADN---------------------- ----------------------DSVGQEEDEPAAGSREPKD------------------- ------------------------------------------------------------ ----------AASQRLPPK----------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------------STAQA----- -QPALWPSRQATSSAQRDRGPAHHSTKPALPA-------------------QRAP----- --------H-------------------------FGGREENSGALVS------------- ------PSK---------------------------LSPPQGGLSRLLPTPPHPGA---- -------PLSRVWKNGHDAPATKSS---------------APSQ---------------- ---------SKSSSSSR------------------------------------------- ------------------------------------------------------------ LSSRTQVPE------------------------------------------GEHAS--DG DGDNDTEDRGRQAEAAAPMSRA---------RLPS------------------------- ----------GPPVSGHLSLFRNKPFAAHTRYPSRFGSSRGPRLHSSSS---PPS---TV SPRVH------------------------------------------------------- --------------------SRVTSHPAS------------------------------- DHRPGSGIHGDGAE---------------------SEAEDEKPLP-------------AT ------------------------------------------------------------ ---------------------VVNNH-M------------A-----------------SS S------------------RQPASLGVDYLRKGPQRGANLQRKEPLAENP---------- -------------------------------KSA-------------------------- ----------------------------------------------------------GT E------------------------AGAHPQGK--------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------SLPSKALDVQQS-TEVGVDGGSPKAQ -------LVPAR------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------LSVSQ-PQPRGPPSKEVGRPLS--K PELP-QAGRP---------------------HSAVQESASFSDPYAARGSQS-------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------PHT-----------------------------A SS--------------------RGVLPTTPHHR--------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -D---------------------------------------------------------- ----------EDSEGRS------------ETSTTAQ---------------------KRR PES--------------------------------------------------------- ------------------------PAHPAR------------------------------ --------------------------------------ARD------------------- ------------------------------------------------------------ ----------------------PNLSLPKHLQLEAHAGGAGDSHLRR----------PPG SPLRPGS----------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------FR---------------------------------- ------------------------------------------------------------ ----------------PGSPRHYPHA---------------------------------- -----------------------------------------------RPRVP-------- -------------------------------------------------------GRAGP QA---------AVPS-------KREPLTS------------------------------- ----------KSPQSVSVEE------------------EREDAMVFKGGKDEDPLSSSVP KWPSSSS-PRGSKYVDG------------------------------NIAKDKTD----- --------------------------------------------------PAIVLSLPR- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------DENDT--------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------PV-------------------------------------- -------------------KRPPPPP-PP------------------------------- ------------------------------------------------------------ ----------------------------SAG------------------SS--PRASHLP PRHPH-----------RSP----------------------------ATPS--------- ---------------------------------PTAGTPARVQ----------------- --------------YTTRAPPVY------------------------------------- ----SST-T--------------------------------------------------- ------------------------------PML----------SLRQRMMN--------- ----S----------RFRNPL-----SRQ-------------PA---------------- ------------------------------------------------------------ ---------------------------RSPT------L------P--------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------GYNGRPNV----------- --EGK---VLPGSNGKPSGQRIINGPQGTKWVVDLNRGLVLNAEGRYLQDSQGNPLRIKL GGDGRTIVDLGGTPVVSPDGLPLFGQGRHGKPVASAQDKPILSLGGKPLVGLE--VVKTT THAP-TT-----TTRL-------------------------T--TTTQRPT-----T--- --------TT-----THRT--TTTT-------------------------------RPTT TTTRPMT-TTTR-------PTTTIR--------TTTQ---------------TTTT--TT ----------TTPEP-------------TT------------------------------ -PVPTCPPGTLERHDEDGNLIM-GSSGVPECY--------------------------P- ------------------------EEDEFSGLETD--------TATPTEEAYVIYDE--- ---------------------D--------YE-FE-TSR-------P-----P---V--- -------TTRPS-------------------------------------------TTA-- ATPE-----------VIPPDGS----------------------I--------------- -----SSFPGEEFDLAGKKRFV--------------------------APYVTYLNKDPS APCSLTDALDHFQVDSLDEIIPND--MRKSDLPPQHPPRNITVVAMEGCHSFVIVDWDKA TPGDVVTGYLVYSASYEDFIRNKWSTQASSVTHLPIENLKPNT----------------- -------------RYYFKVQAKNPHGYGPISPSVSFVTESDNPLLVVRPPG--------- ------GEPIWIPFTFKHDPSYTDCHGRQYVKRTWYRKFVGVVLCNSLRYKIYLSDNL-K -DTFYSIGDSWGRGEDHCQFVDSHLDGRTGPQSYVEALPTIQGYFRQYRQEPVSFGNIGF GTPYYYVGWYECGVSIPGKW---------------------------------------- ------------------------------------------------------ >ENSNVIP00000012702 DRCKAGLGRTVSRFINWS----------------------SL------------------ ------------------------------------------------------------ ---------------------------------------------------QIDSYAVC- ------------------------------------------------------------ --------------------------------------------------IA-------- ------------------------------------------------------------ -------------------------------------------------DHPL------- -----------------------KPRHVKLLSTKMGLKVTWDPPKDATSRPV----EHYN ------------------------------------------------------I-AYGK S-----------------------------------------------LK---------- -----------SLKYIKVNAETYSFLIDDV--------------------------EPGV VYFVLVTAENHN--------GVSRPVYRAESLP--------------------------- -------------------------------------------------------GG--- ---------------------------------EWIQIDGFPIKGPGP------------ ------------------FNETVT------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------EKEVPNKPLRVRVRSS-------------------------------------- -----------------DDRLSVAWKAPRL-SGAKS-------PR-RSRGFLLGYG---- -ESGRKMNY------------VPLTRDERTHEIKKL---ASESV---------------- ---------YVVSLQSMN-----------------SQGQSQPVYRAALTKRKISEE---- ---DELDVPEDINVRVMSSQSVLVAWVDPVLE-KQKKVV--AS-RQYTVRYREKGELARW DHKQTSNRRVLVENLIPDTMYEFAVRISQGERDGKWSTSVFQRTPESAPTTAPENLNVWP VNGKSTAVTVAWDALPETEGKVKEYILSYAPALKPFGAKSLTYPGETTSALVDGLQPGER YLFKIRAANRRGLGPHSKAFIVAMPT-----------T-GSGKSDVQQKTHAEDEWTSEK PE-------------------------------------------------TSPKVPA-- -------STKHTH-L--------------------------------------------- --------PVSPRGRNVKNPLLDLKNKILANGGVPRRPQLHPKRTEVL---DLQS----T EITD-------EEELDSQGDPPTLPSE-------------TQE----------------- -----------QKPQQRP--PSRAVPPVLAPGRTPVGVQTPVLPRKEGTDR-GGSSLPSH --------PH---------------------------------------PGTS------S -------------SARHTSIEGSPRR---------------------------------- ------------------------------------------------------P----- ------------------------------------------------------------ ------------------SGGPS-----THLPSSSTDN---------------------- ----------------------DSVGQEEEEPATGSRDPKD------------------- ------------------------------------------------------------ ----------GASQRLPPK----------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------------NTAQT----- -RPALWPSRQATSSALRDRGPAHHSTKPALPA-------------------RRAP----- --------H-------------------------FGGREENSGASVS------------- ------SSK---------------------------FSPPQEGSSRLLPTEPHPGS---- -------PLSRGWKDGQDTPASKSS---------------VPSQ---------------- ---------SKSSWSSG------------------------------------------- ------------------------------------------------------------ LSSRTQVSE------------------------------------------REDAS--DE DGDNDTEDRGRQAEATAPTSRA---------RLPA------------------------- ----------GPPVSGHFSLFRNKPFAAHTRYPSRAGSGRGPRLHPSSS---PRS---TV SPRVH------------------------------------------------------- --------------------SRVNSHPAS------------------------------- DHRQGLGIHGDGAE---------------------SEAEDEKPLP-------------AT ------------------------------------------------------------ ---------------------VVKDH-V------------S-----------------SS S------------------REPASLGVDSLRKGPQRGASLQRKEPLAENP---------- -------------------------------KFA-------------------------- ----------------------------------------------------------GT E------------------------AGAHPQGK--------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------SLAPKALDVQQS-TEVGVEGGDPKAQ -------LAPARR----------------------------------------------- ---------------------------------------------------PAT------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------RSQH----------------- ------------------------------------------------------------ ---------------------------------------------------HPG-PGVPR RTAPGQG---LG----------ARAGAPEGQPSPAVSVSQ-PQPRGPPSKEVGRPLSKPK PELA-QAGRP---------------------HPA---APSFPDPYAARGSQT-------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------PHR-----------------------------A SS--------------------RGVLPTSPHHR--------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -D---------------------------------------------------------- ----------EDSEGR-------------------------------------------- --SGGNRHDSTEAEARA------------------------------------------- ---------------------ARAPAHPAR------------------------------ --------------------------------------TSD------------------- ------------------------------------------------------------ ----------------------PILSLPKPRQLEAHAGGAGDSHLRR----------PPS SPL--------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------R---------------------------------- ------------------------------------------------------------ ----------------PGSPRHYPHA---------------------------------- -----------------------------------------------RPRVP-------- -------------------------------------------------------GRVGS QAVGNKDRAPQAAPS-------KREPLTS------------------------------- ----------KSQQSVSAEE------------------EGEDVMFFKGGKDEDPL-SSVP KWPSSSS-PRASKYVDG------------------------------NIAKDKRD----- --------------------------------------------------PAIVLSLPRV ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------------G SPQ--------------------------------------------------------- ----------------------DENDT--------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------PV-------------------------------------- -------------------KRPPPPP-P-------------------------------- ------------------------------------------------------------ ------------------------------G------------------SS--PRASHLP PRPPQ-----------RSP----------------------------STPS--------- ---------------------------------PTTGTPAGER----------------- --------------YTSRAPPVY------------------------------------- ----SST-T--------------------------------------------------- ------------------------------PML----------SLRQRMMN--------- ----A----------RFRNPL-----SRQ-------------PA---------------- ------------------------------------------------------------ ---------------------------RSPA------R------Q--------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------GYNGRPNV----------- --EGQ---VLPGSNGNPSGQRIINGPQGTKWVVDLDRGLVLNAEGRYLQDSQGNPLRIKL GGDGRTIVDLGGTPVVSPDGLPLFGQGRHGKPVASAQDKPILSLGGKPLVGLE--VVKTT TRAP-TT-----TTRP-------------------------T--TTTPRPT-----T--- --------TA-----TRRT--TTT----------------------------------TT TTTRATT-TTTR-------PTTTIR--------TTTQ---------------TTTT--TT ----------TTPEP-------------TT------------------------------ -PVPTCPPGTLERHDENGNLIT-GSSGAPECY--------------------------P- ------------------------EEDEFSGLETD--------TAMPTEEAYVIYDE--- ---------------------D--------YE-FE-TSR-------P-----P---T--- -------TTRPS-------------------------------------------TTA-- AVPE-----------VISPEGS----------------------I--------------- -----SSFPGEEFDLAGKKRFV--------------------------APYVTYLSKDPS APCSLTDALDHFQVDSLDEIIPND--MRKSDLPPQHPPRNITVVAMEGCHSFVIVDWDKA TPGDVVTGYLVYSASYEDFIRNKWSTQASSVTHLPIENLKPNT----------------- -------------RYYFKVQAKNPHGYGPISPSVSFVTESDNPLLVVRPPG--------- ------GEPIWIPFAFKHDPSYTDCHGRQYVKRTWYKKFVGVVLCNSLRYKIYLSDNL-K -DTFYSIGDSWGRGEDHCQFVDSHLDGRTGPQSYVEALPTIQGYFRQYRQEPVSFGNIGF GTPYYYVGWYECGVSIPGKW---------------------------------------- ------------------------------------------------------ >ENSMPUP00000005066 ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------VDSCAVC- ------------------------------------------------------------ --------------------------------------------------IA-------- ------------------------------------------------------------ -------------------------------------------------DHPL------- -----------------------KPRHVKLLSTKMGLKVTWDPPKDATSRPV----EHYN ------------------------------------------------------I-AYGK S-----------------------------------------------LK---------- -----------SLKYIKVNAETYSFLIDDV--------------------------EPGV VYFVLVTAENHN--------GVSRPVYRAESPP--------------------------- -------------------------------------------------------GG--- ---------------------------------EWIQIDGFPIKGPGP------------ ------------------FNETVT------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------EKEVPNKPLRVRVRSS-------------------------------------- -----------------DDRLSVAWKAPRL-SGAKS-------PR-RSRGFLLGYG---- -ESGRKMNY------------VPLTRDERTHEIKKL---ASESV---------------- ---------YVVSLQSMN-----------------SQGQSQPVYRAALTKRKISEE---- ---DELDVPEDINVRVMSSQSVLVAWVDPVLE-KQKKVV--AS-RQYTVRYREKGELARW DHKQTSNRRVLVENLIPDTMYEFAVRISQGERDGKWSTSVFQRTPESAPTTAPENLNVWP VNGKPTAVTVAWDALPETEGKVKEYILSYAPALKPFGAKSLTYPGETTSALVDGLQPGER YLFKIRAANRRGLGPHSKAFIVAMPT-----------T-GSGKSDVQQKTHAEDDWKSEK PE-------------------------------------------------TSPKVPA-- -------STKHTH-L--------------------------------------------- --------PVSPRGRNVKNPLLDLKNKILANGGVPRRPQLHPKRTEVL---DLQS----T EITD-------EEELDSQGDPPTLPSE-------------TQE----------------- -----------RKPQQRP--PSRAVPPVLVPGRTPVGVQTPGWPRKEGADR-GGSSLSSH --------PH---------------------------------------PGTS------S -------------SARHTPIEGSPRR---------------------------------- ------------------------------------------------------P----- ------------------------------------------------------------ ------------------SGGPS-----THLPPSATDN---------------------- ----------------------DSVGQGEDEPATGSRDPKD------------------- ------------------------------------------------------------ ----------GASQRLSPK----------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------------STAQA----- -RPALWPSRQATSSALRDRGPAHHSTKPALPA-------------------RRAP----- --------H-------------------------FGGREENSGASLS------------- ------SSK---------------------------FSPPQEGSSRPLPTEPHPRA---- -------PLSRGWKDGQDTPASKSS---------------VPSQ---------------- ---------SKSSWSSG------------------------------------------- ------------------------------------------------------------ LSSRTQASE------------------------------------------REDAS--DE DGDNDTEDRGRQAEATAPTSRA---------RLPA------------------------- ----------GPPVSGHFSLFRNKPFAAHTRYPSRAGSGRGPRLHPSSS---PPS---TV SPRVH------------------------------------------------------- --------------------SRVNSHPAS------------------------------- DHRQGLGIHGDGAE---------------------SEAEDEKPLP-------------AA ------------------------------------------------------------ ---------------------VVNDH-V------------S-----------------PS S------------------RKPASLGVDPLRKGPQRGASLQRKEPLAENP---------- -------------------------------KFA-------------------------- ----------------------------------------------------------GT E------------------------AGAHPQGK--------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------SLASKALDVQQS-TEVGVEGGDPKAQ -------LAPARR----------------------------------------------- ---------------------------------------------------PAT------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------RSQH----------------- ------------------------------------------------------------ ---------------------------------------------------HPG-PGVPR RTAPGQG---LG----------ARAGAPEGQPSPAVSVSQ-PQPRGPPSKEVGRPLSQPK PELP-QAGRP---------------------HPA---APSFPDPYAARGSQT-------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------PHR-----------------------------A SS--------------------RGVLPTSPHHR--------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -D---------------------------------------------------------- ----------EDSEGR-------------------------------------------- --SGGNSHDSAEAEARA------------------------------------------- ---------------------ARASAHPAR------------------------------ --------------------------------------ASD------------------- ------------------------------------------------------------ ----------------------PILSLPKPRQLEAHAGGAGDSHLRR----------PPS SPL--------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------R---------------------------------- ------------------------------------------------------------ ----------------PGSPRHYPHA---------------------------------- -----------------------------------------------RPRVP-------- -------------------------------------------------------GRVGP QAVGNKDRAPQAAPS-------EREPLTP------------------------------- ----------KSQQSVSAEE------------------EGEDAMFFKGGKDEDPL-PSVP KWPSPSR-PRASKYVDG------------------------------NIAKDKRD----- --------------------------------------------------PAIVLSLPRA ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------------G SPQ--------------------------------------------------------- ----------------------DENDT--------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------PV-------------------------------------- -------------------KRPPPPP-P-------------------------------- ------------------------------------------------------------ ------------------------------G------------------SS--PRASHLP PRPPQ-----------RSP----------------------------STPS--------- ---------------------------------PATGTPARER----------------- --------------YTSRAPPVY------------------------------------- ----SST-T--------------------------------------------------- ------------------------------PML----------SLRQRMMN--------- ----A----------RFRNPL-----SRQ-------------PA---------------- ------------------------------------------------------------ ---------------------------RSPA------R------Q--------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------GYNGRPNV----------- --EGE---VLPGSNGNPSGQRIINGPQGTKWVVDLDRGLVLNAEGRYLQDSQGNPLRIKL GGDGRTIVDLGGTPVVSPDGLPLFGQGRHGKPVASAQDKPILSLGGKPLVGLE--VVKTT TRAP-TT-----TTRP-------------------------T--TTTPRPT-----T--- --------TA-----TRRT--STT----------------------------------TT TTTRPTT-TTTR-------PTTTIR--------TTTQ---------------TTTT--TT ----------TTPEP-------------TT------------------------------ -PVPTCPPGTLERHDENGNLIT-GSSGVPECY--------------------------P- ------------------------EEDEFSGLETD--------TAMPTEEAYVIYDE--- ---------------------D--------YE-FE-TSR-------P-----P---T--- -------TTRPS-------------------------------------------TTA-- AVPE-----------VISPEGS----------------------I--------------- -----SSFPGEEFDLAGKKRFV--------------------------APYVTYLSKDPS TPCSLTDALDHFQVDSLDEIIPND--MRKNDLPPQHPPRNITVVAMEGCHSFVIVDWDKA TPGDVVTGYLVYSASYEDFIRNKWSTQASSVTHLPIENLKPNT----------------- -------------RYYFKVQAKNPHGYGPISPSVSFVTESDNPLLVVRPPG--------- ------GEPIWIPFAFKHDPSYTDCHGRQYVKRTWYKKFVGVVLCNSLRYKIYLSDNL-K -DTFYSIGDSWGRGEDHCQFVDSHLDGRTGPQSYVEALPTIQGYFRQYRQEPVSFGNIGF GTPYYYVGWYECGVSIPGKW---------------------------------------- ------------------------------------------------------ >ENSFCAP00000060389 -----------------------------------------M------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------------A-------- ---PEAGAAPRARCP-LPWAA-LLLLAALLPVVSPAG-AP-------------------- ------------------------------------------------ADHPL------- -----------------------KPRHVKLLSTKMGLKVTWDPPKDATSRPV----EHYN ------------------------------------------------------I-AYGK S-----------------------------------------------LK---------- -----------SLKYIKVNAETHSFLIEDV--------------------------EPGV VYFVLVTAENHN--------GVSRPVYRAESLP--------------------------- -------------------------------------------------------GG--- ---------------------------------EWIKIDGFPIKGPGP------------ ------------------FNETVT------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------EKEVPNKPLRVRVRSS-------------------------------------- -----------------DDRLSVAWKAPRL-SGAKS-------PR-RSRGFLLGYG---- -ESGRKMNY------------VPLTRDERTHEIKKL---ASESV---------------- ---------YVVSLQSMN-----------------SQGQSQPVYRAALTKRKISEE---- ---DDLDVPEDINVRVMSSQSVLVAWVDPVLE-KQKKVV--AS-RQYTVRYREKGESARW DHKQTSNRRVLVENLIPDTMYEFAVRISQGERDGKWSTSVFQRTPESAPTTAPENLNVWP VNGKSTAVTVAWDALPETEGKVKEYILSYAPALKPFGAKSLTYPGETTSALVDGLQPGER YLFKIRAANRRGLGPHSKAFIVAMPT-----------T-GPGVSDV-QKTHAEDNWKPEK PE-------------------------------------------------MSPKAPT-- -------SSKHTH-L--------------------------------------------- --------PVSPRGRNVKNPLLDLKNKILANGGVPRKPQVHSKKTAVL---DLQS----T EITG-------EEELDSPGDPPTASSE-------------TQD----------------- -----------QKPQQRP--PSRSVPPALAPGRTPARAHTLALPRKESVDR------APY --------PR---------------------------------------PGASPSVPA-A -------------SAPHTPTEGSPHR---------------------------------- ------------------------------------------------------P----- ------------------------------------------------------------ ------------------SGGPF-----PNLPSSSADN---------------------- ----------------------DSVGQEEEEPAAGSPAPKD------------------- ------------------------------------------------------------ ----------TASLRPPPK----------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------------SPTHA----- -RPALWPSRQAPSSALRDRSPAHHGTKPALPA-------------------RRTP----- --------H-------------------------LGDREENSDASVP------------- ------PSK---------------------------LSPPQGGSSRVLPPEPHPRA---- -------PLSRGWKAGQDTPATKSS---------------APSQ---------------- ---------SKSSSSSG------------------------------------------- ------------------------------------------------------------ VSSRTQASE------------------------------------------GGDTS--DG AGDNDTEDKGRQAEATAPTSRA---------RLPV------------------------- ----------GPPVSGHFSLFRNKPFAAHTRYPSRFGSGRGLRLHPSSS---PPS---TV SPRVH------------------------------------------------------- --------------------SRVNSQSAA------------------------------- DHTHGSSIHRDGAE---------------------SEAEDEKPLP-------------AT ------------------------------------------------------------ ---------------------VVHDH-VS----------SS-----------------SS S------------------RQPSSLGVDHLRGSPQRGVSAQRKEPLAENP---------- -------------------------------KSA-------------------------- ----------------------------------------------------------GT V------------------------AGAHPPGK--------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------VLPPKAQDVQQS-TEVAVERGYPKAQ -------LA--------------------------------------------------- ---------------------------------------------------PAL------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------RSQH----------------- ------------------------------------------------------------ ---------------------------------------------------HPG-ASV-- -------------------------------PSSEVSVAQ-PQPRGPQNKEMGRLSANPQ PE------RP---------------------HPAAQESASFSDPYAARGSQS-------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------PHT-----------------------------A NS--------------------RGVLPTSPHNR--------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -K---------------------------------------------------------- ----------EDSEGR-------------------------------------------- --SGGTPHDGAEAAARAREA---------------------------------------- --------------------TA-------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -------------------------SLPKHSQLEAQAGGAGDSHLRRPL------VSPP- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------R---------------------------------- ------------------------------------------------------------ ----------------PGSPRPHPLA---------------------------------- -----------------------------------------------RPRGP-------- -------------------------------------------------------GRLGP QAVGKKD---PASPS-------KRQPLPS------------------------------- ----------KSQQSVSAED------------------DDEDAMFFKGAKDKDPLSSSVL KWPSSSS-PRGGKYADG------------------------------HSAKDKTE----- --------------------------------------------------PLVVPVPPRV ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------------S SPQ--------------------------------------------------------- ----------------------DENDT--------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------PV-------------------------------------- -------------------QR--PPL-P-------------------------------- ------------------------------------------------------------ ------------------------------G------------------SP--PRAPHLP PRPPH-----------RSP----------------------------ATAG--------- ---------------------------------PA----ARVR----------------- --------------FTTRAPPAY------------------------------------- ----TAT-T--------------------------------------------------- ------------------------------PML----------SLRQRMMN--------- ----S----------RFRNPL-----ARQ-------------PV---------------- ------------------------------------------------------------ ---------------------------RSPT------R------P--------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------GYNGRPNV----------- --DAK---VLPGSNGKPSGQRIINGPQGTKWVVDLDRGLVLNEEGRYLQDSQGTPLRIKL GGDGRTIVDLGGTPVVSPDGLPLFGQGRHGKPLASAQDKPILSLGGKPLVGLE--VVKTT TRAP-AT-----TTPP-------------------------T--TTTPRPT-----T--- --------TT-----TRRT----------------------------------------- ------T-TTTR-------PTTTIR--------TTTQ---------------------TT ----------TTPEP-------------TT------------------------------ -PVPTCPPGTLERHDEDGNLIM-GSSGVPECH--------------------------P- ------------------------EEDDFSGLESD--------TAIPTEEAYVIYDE--- ---------------------D--------YE-VE-TSS-------P-----P---TTSR PPTTRPPTTRPP-------------------------------------------TTA-- AAPE-----------VIPTEGS----------------------I--------------- -----SSFPGEEFDLAGKKRFV--------------------------APYVTYLSKDPS APCSLTDALDHFQVDSLDELIPND--MRKSDLPPQHAPRNITVVAMEGCHSFVIVDWDKA TPGDVITGYLVYSASYEDFIRNKWSTQASSVTHLPIENLKPNT----------------- -------------RYYFKVQAKNPHGYGPISPSVSFVTESDNPLLVVRPPG--------- ------GEPIWIPFAFKHDPSYTDCHGRQYVKRTWYRKFVGVVLCNSLRYKIYLSDNL-K -DTFYNIGDSWGRGEDHCQFVDSHLDGRTGPQSYVEALPTIQGYYRQYRQEPVSFGNIGF GTPYYYVGWYECGVSIPGKW---------------------------------------- ------------------------------------------------------ >ENSECAP00000000184 -----------------------------------------M------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------------A-------- ---PEAGAPPRARRP-LPWAA-LLLLAALLPVVSSAG-AP-------------------- ------------------------------------------------ADHPL------- -----------------------KPRHVKLLSTKMGLKVTWDPPKDATSRPV----EHYN ------------------------------------------------------I-AYGK S-----------------------------------------------LK---------- -----------SLKYIKVNAETHSFLIEDV--------------------------EPGV VYFVLVTAENHN--------GVSRPVYRAESPP--------------------------- -------------------------------------------------------GG--- ---------------------------------EWIKIDGFPIKGPGS------------ ------------------FNETVT------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------EKDVPNKPLRVRVRSS-------------------------------------- -----------------DDRLSVAWKAPRL-SGAKS-------PR-RSRGFLLGYG---- -ESGRKMNY------------VPLTRDERTHEIKKL---ASESV---------------- ---------YVVSLQSMN-----------------AQGRSQPVYRAALTKRKISEE---- ---DEMDVPEDINVRVMSSQSVLVAWVDPVLE-KQKKVV--AS-RQYTVRYREKGESARW DYKQISHRRVLIENLIPDTMYEFAVRISQGERDGKWSTSVFQRTPESAPTTAPENLNVWP VNGKPTAVTVAWDALPETEGKVKEYILSYAPALKPFGAKSLTYPGDTTSAIVDGLQPGER YLFKIRAANRRGMGPHSKAFIVAMPT-----------T-PTSASDVQRKANTEDNSKPEK PE----------------------------------------------PSAPSPKAPA-- -------SSKHTH-L--------------------------------------------- --------PVSPRGRNVKNPLLDLKNKILANGGVPRKPLLPPRKPEEL---DLQS----T ELTD-------DEELESRADPPTSPSE-------------IQD----------------- -----------QKPQQRP--PIRSVHPVFAPGRTPMRARMPVLPRKEGVDK-RGSLLASH --------PR---------------------------------------PGASPSASA-S -------------SVPQ-PTEGSPHR---------------------------------- ------------------------------------------------------P----- ------------------------------------------------------------ ------------------SGRPS-----THLPSSSVDN---------------------- ----------------------DSLGQDEEEPAAGSPHPKE------------------- ------------------------------------------------------------ ----------AVSQQLPPK----------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------------SAAHS----- -RPALPSSRQSAWNAMRDRSSAHHSAKPALPA-------------------RRAP----- --------Y-------------------------SEDAEENSSAPVP------------- ------PSR---------------------------LSPPHGGSSRLLPAEPHSRS---- -------PLSRGWKDGHYAAAAKSN---------------APSRPSKFP----------- ------SVSSR------------------------------------------------- ------------------------------------------------------------ LSSRTQVSE------------------------------------------GADASDGDG DGDNDAEAKGRQTEATAPTFRT---------RLPA------------------------- ----------GPPVSGHFSLLRNRPFAAHGRYLNRFGNGRGPRFQPSSP---PPS---TV SPRVP------------------------------------------------------- --------------------SRVSSHPAS------------------------------- NHRRGSSTHEDSEE---------------------REAEDEKPLP-------------AT ------------------------------------------------------------ ---------------------VVNDH-V------------P-----------------SS S------------------RQPAFRGVDHLRRGPQKGTNLLRKESVAENP---------- -------------------------------KAA-------------------------- ----------------------------------------------------------GT W------------------------AGAHPQGK--------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------A-GSKAQDVQQS-TDVGAEGGSRKTQ -------LSPAPP----------------------------------------------- ---------------------------------------------------PAA------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------RSQH----------------- ------------------------------------------------------------ ---------------------------------------------------HPG-SSVPK RM---------G----------AGAAAAEKQPSSAISVSQ-QQPRGPQGKEVGRAPS--K PALP-QAGRP---------------------HPTSQGIASFSDPYASRDSQS-------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------PHA-----------------------------A NS--------------------QRVRPTSPQN---------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------QNG---------DGDSRYGENQE-- --------DSTEAEARG------------------------------------------- ---------------------VRAPAPPAR------------------------------ --------------------------------------AKE------------------- ------------------------------------------------------------ ----------------------ATLSLPKHRQVEAQPGSAGDSHLRR----------PPG SSPRPG------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------R---------------------------------- ------------------------------------------------------------ ----------------PGSP--HPYA---------------------------------- -----------------------------------------------RPRVP-------- -------------------------------------------------------GRAGP Q----------ATPS-------KKESLSS------------------------------- ----------KSQQSVSAED------------------D-EDAGFFKGGKDQDLLSSSVA KWPPSSS-PRGSKYADG------------------------------KMAKEKTE----- --------------------------------------------------ATLVLAPPRV ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------------S SSQ--------------------------------------------------------- ----------------------EDNDT--------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------PV-------------------------------------- -------------------KRPLSPP-P-------------------------------- ------------------------------------------------------------ ------------------------------G------------------SS--PRASHLP PRQPP-----------RSP----------------------------ATPS--------- ---------------------------------PTVGTPAWAR----------------- --------------YTTRAPPVY------------------------------------- ----SST-T--------------------------------------------------- ------------------------------PML----------SLRQRMMN--------- ----S----------RFRNPL-----SRQ-------------PV---------------- ------------------------------------------------------------ ---------------------------RPPF------R------Q--------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------GYNGRPNG----------- --EGK---VLPGSNGKPNGQRIINGPQGTKWVVDLDRGLVLNAEGRHLQDSHGNPLRVKL GGDGRTIVDLGGTPVVSPDGLPLFGQGRHGKPLASAQDKPILSLGGKPLVGLE--VIKTT TRVP-TT-----TTRP----------------------------TTTPRPT-----T--- --------TT-----RRPT----------------------------------------- ------T-TTTR-------PTTTIR--------TTTQ----------------TTT--TT ----------TTPQP-------------TT------------------------------ -PIPTCAPGTLERHDEDGNLIM-GSNGVPECY--------------------------P- ------------------------EEDEFSGLETD--------TAIPTEEAYVIYDE--- ---------------------D--------YE-FE-TSK-------PQATTTP---TTT- ------PSTTPS-------------------------------------------TTA-- ATPK-----------VIPPEGS----------------------I--------------- -----SSFPEEEFDLAGKKRFV--------------------------APYVTYLNKDPS APCSLTDALDHFQVESLDEIIPND--LRKSDLPPQHVPRNITVVAVEGCHSFVIVDWDKA SPGDVVTGYLVYSASYEDFIRNKWSTQASSVTHLPIENLKPNT----------------- -------------RYYFKVQAQNPHGSGPISSSVSFVTESDNPLLVVRPPG--------- ------GEPIWIPFSFKHDPSYTDCHGRQYVKRTWYRKFVGVVLCNSLRYKIYLSDNL-K -DTFYSIGDSWGRGEDHCQFVDSHLDGRTGPQSYIEALPAIQGYYRQYRQEPVSFGSIGF GTPYYYVGWYECGVSIPGKW---------------------------------------- ------------------------------------------------------ >ENSEASP00005027961 -----------------KVGFAFASSPGAAALSSSSGGSGT------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------------DHPL------- -----------------------KPRHVKLLSTKMGLKVTWDPPKDATSRPV----EHYN ------------------------------------------------------I-AYGK S-----------------------------------------------LK---------- -----------SLKYIKVNAETHSFLIEDV--------------------------EPGV VYFVLVTAENHN--------GVSRPVYRAESPP--------------------------- -------------------------------------------------------GG--- ---------------------------------EWIKIDGFPIKGPGS------------ ------------------FNETVT------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------EKDVPNKPLRVRVRSS-------------------------------------- -----------------DDRLSVAWKAPRL-SGAKS-------PR-RSRGFLLGYG---- -ESGRKMNY------------FPLTRDERTHEIKKL---ASESV---------------- ---------YVVSLQSMN-----------------AQGRSQPVYRAALTKRKISEE---- ---DEMDVPEDINVRVMSSQSVLVAWVDPVLE-KQKKVV--AS-RQYTVRYREKGESARW DYKQISHRRVLIENLIPDTMYEFAVRISQGERDGKWSTSVFQRTPESAPTTAPENLNVWP VNGKPTAVTVAWDALPETEGKVKEYVLSYAPALKPFGAKSLTYPGDTTSAIVDGLQPGER YLFKIRAANRRGMGPHSKAFIVAMPT--------------SNASDVQRKANTEDNSKPEK PE----------------------------------------------PSAPSPKAPA-- -------SSKHTH-L--------------------------------------------- --------PVSPRGRNVKNPLLDLKNKILANGGVPRKPLLPPRKPEGL---DLQS----T ELTD-------DEELESRADPPTSPSE-------------IQD----------------- -----------QKPQQRP--PIRSVHPVFAPGRTPVRARMPVLPRKESVDK-RGSLLASH --------PR---------------------------------------PGASPSASA-S -------------SVPQ-PTEGSPHR---------------------------------- ------------------------------------------------------P----- ------------------------------------------------------------ ------------------SGRPS-----THLPSSSFDN---------------------- ----------------------DSLGQEEEEPAAGSPHPKE------------------- ------------------------------------------------------------ ----------AVSQQLPLK----------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------------SAAHS----- -RPALPSSRQSAWNAMRDRSSA---AKPALPA-------------------RRAP----- --------Y-------------------------SEDAEENSSAPVP------------- ------PSR---------------------------LSPPHGGSSRLLPAEPHSRS---- -------PLSRGWKDGHYAAAAKSN---------------APSRPSKFP----------- ------SVSSR------------------------------------------------- ------------------------------------------------------------ LSSRTQVSE------------------------------------------GADASDGDG DGDNDAEAKGRQTEATAPTFRT---------RLPA------------------------- ----------GPPVSGHFSLLRNRPFAAHGRYPNRFGNGRGPRFQPSSP---PPP---TV SPRVP------------------------------------------------------- --------------------SRVSSHPAS------------------------------- NHRRGSSTHEDSEE---------------------REAEDEKPLP-------------AT ------------------------------------------------------------ ---------------------VVNDH-V------------P-----------------SS S------------------RQPAFRGVDHLRRGPQKGTNLLRKESVAENP---------- -------------------------------KAA-------------------------- ----------------------------------------------------------GT W------------------------AGAHPQGK--------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------A-ESKAQDVQQS-TDVGAEGGSRKTQ -------LSPAPP----------------------------------------------- ---------------------------------------------------PVA------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------RSQH----------------- ------------------------------------------------------------ ---------------------------------------------------HPG-SSVPK RM---------G----------AGAAAAEKQPSSAISVLQ-QQPRGPQGKEVGRAPS--K PALP-QAGRP---------------------HPTSQGSASFSDPYASRDSQS-------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------PHA-----------------------------A NS--------------------RRVRPTSPQN---------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------QNG---------DGDSRYGENQE-- --------DSTEAEARG------------------------------------------- ---------------------VRAPAPPAR------------------------------ --------------------------------------AKE------------------- ------------------------------------------------------------ ----------------------ATLSLPKHRQVETQPGSAGDSHLRR----------PPG SSP--------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------R---------------------------------- ------------------------------------------------------------ ----------------PGSP--HPYA---------------------------------- -----------------------------------------------RPRVP-------- -------------------------------------------------------GRAGP Q----------ATPS-------KKESLSS------------------------------- ----------KSQQSVSAED------------------D-EDAGFFKGGKDQDLLSSSVA KWPPSSS-PRGSKYADG------------------------------KMAKEKTE----- --------------------------------------------------PTLVLAPPRV ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------------S SSQ--------------------------------------------------------- ----------------------EDNDT--------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------PV-------------------------------------- -------------------KRPLSPP-S-------------------------------- ------------------------------------------------------------ ------------------------------G------------------SS--PRAPHLP PRQPP-----------RSP----------------------------ATLS--------- ---------------------------------PTVGTPAWAR----------------- --------------YTTRAPPVY------------------------------------- ----SST-T--------------------------------------------------- ------------------------------PML----------SLRQRMMN--------- ----S----------RFRNPL-----SRQ-------------PV---------------- ------------------------------------------------------------ ---------------------------RPPF------R------Q--------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------GYNGRPNG----------- --EGK---VLPGSNGKPNGQRIINGPQGTKWVVDLDRGLVLNAEGRHLQDSHGNPLRVKL GGDGRTIVDLGGTPVVSPDGLPLFGQGRHGKPLASAQDKPILSLGGKPLVGLE--VIKTT TRVP-TT-----TTRP----------------------------TTTPRPT-----T--- --------TT-----RRPT----------------------------------------- ------T-TTTR-------PTTTIR--------TTTQ----------------TTT--TI ----------TTPQP-------------TT------------------------------ -PIPTCAPGTLERHDEDGNLIM-GSNGVPECY--------------------------P- ------------------------EEDEFSGLETD--------TAIPTEEAYVIYDE--- ---------------------D--------YE-FE-TSK-------PQATTTP---TTT- ------PSTTPS-------------------------------------------TTA-- ATPK-----------VIPPEGS----------------------I--------------- -----SSFPEEEFDLAGKKRFV--------------------------APYVTYLNKDPS APCSLTDALDHFQVESLDEIIPND--LRKSDLPPQHVPRNITVVAVEGCHSFVIVDWDKA SPGDVVTGYLVYSASYEDFIRNKWSTQASSVTHLPIENLKPNT----------------- -------------RYYFKVQAQNPHGSGPISSSVSFVTESDNPLLVVRPPG--------- ------GEPIWIPFSFKHDPSYTDCHGRQYVKRTWYRKFVGVVLCNSLRYKIYLSDNL-K -DTFYSIGDSWGRGEDHCQFVDSHLDGRTGPQSYIEALPAIQGYYRQYRQEPVSFGSIGF GTPYYYVGWYECGVSIPGKW---------------------------------------- ------------------------------------------------------ >ENSBTAP00000039682 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------------MA-------- ---PEVRASHRARRP-LPWAA-LLLLAALLPVVSPAGAAP-------------------- ------------------------------------------------ADHPL------- -----------------------KPRHVKLLSTKMGLKVTWDPPKDATNRSV----EHYN ------------------------------------------------------I-AYGK S-----------------------------------------------LK---------- -----------SLKYIKVNAETHSFLIEDV--------------------------EPGV VYFVLVTAENSN--------GVSRPVYRAESLP--------------------------- -------------------------------------------------------GG--- ---------------------------------EWIKIDGFPIKGPGP------------ ------------------FNETVT------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------EKDVPNKPLRVRVRSS-------------------------------------- -----------------DDRLSVAWKAPRL-SGAKS-------PR-RSRGFLLGYG---- -ESGRKMNY------------VPLTRDERTHEIKKL---ASESV---------------- ---------YVVSLQSMN-----------------SRGQSQPVYRAALTKRKISEE---- ---DELDVPEDINVRVMSSQSVLVAWVDPVLE-KQKKVV--AS-RQYTVRYREKGESARW DYKQVSNRRVLVENLSPDTMYEFAVRISQGERDGRWSTSVFQRTPESAPTSAPENLNVWP VNGKPTAVTVAWDALPETEGKVKEYILSYAPALKPFGAKSLTYPGETTSARVEGLQPGER YLFKIRAANRRGMGPHSKAFIVALPP-----------T-PTSESEVQQKTDREDQHKPEK PE----------------------------------------------PS-SSPKAPA-- -------PSKHTH-L--------------------------------------------- --------PVSPQGRNVKSPILDFKNKILANGGLLRKAQLPPRKNGGL---GLQS----T EITD-------EEEPDSRGDPPTSPPE-------------TQG----------------- -----------QKSQQRP--PSRPVHPFLAAGRTPVRARTPMLPRKEGVDQ-RGSSPTSH --------PR---------------------------------------PGAPPSASA-S -------------F--------SASR---------------------------------- ------------------------------------------------------PPP--- -------------------------------------------------------ESSTH ----------------RLSGGPS-----TSRPSSSTDN---------------------- ----------------------DSVGLEEEETTARSPPPKD------------------- ------------------------------------------------------------ ----------ALSEHLPGK----------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------------SAAHA----- -QPALSSGRHPAWSALRDRSAAHHGTRPALPA-------------------RRAP----- --------H-------------------------SEDREEGSRASAP------------- ------PSR---------------------------LSPSPGGSSRLLITEPQPGS---- -------PLSRGWKDGQDAPAARSN---------------APSG---------------- --------------STR------------------------------------------- ------------------------------------------------------------ PSSRTQASE------------------------------------------GAGGS--DG DGESDTEERGRPAAATAPTFRS---------RLPA------------------------- ----------GPPVSGHFSSLRNRPFAAHGRYPHRFGNGRGPRLHPSSS---PPS---TA SPRVH------------------------------------------------------- --------------------LRVDSHPAS------------------------------- DHRRGPGGQED-SE---------------------EEAEDEKPLP-------------AT ------------------------------------------------------------ ---------------------VVNHH-V------------S-----------------SS S------------------RQPASRGADHLRRGPQRGASLQRKEPLPENP---------- -------------------------------KST-------------------------- ----------------------------------------------------------GT W------------------------AGVPPQAK--------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------PPSSKAQDTQQS-TDAGAEGGSPKTQ -------LG-GRP----------------------------------------------- ---------------------------------------------------PAP------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------RSPH----------------- ------------------------------------------------------------ ---------------------------------------------------HQE-PTGPQ RM---------G----------AGSAALQKSPSVAVPASQ-PQPHGPRSKEVGRPPSRPQ PAFPSEAGRP---------------------HPTSQESASFSDSYSSRGGQSS------- ------------------------------------------------------------ --------------------------------RAASPQNLDDDSAEAGTGGVRAPAY--- -------------------SAGAKDATP-------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------SLPKHRQVDAQAGSAGDGHLRR----------PAG ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------R---------------------------------- ------------------------------------------------------------ ----------------PGSL--HPHA---------------------------------- -----------------------------------------------RTRVP-------- -------------------------------------------------------GRVGP QWAGRKDGASQASPA-------KREPLPS------------------------------- ----------KSQQSVSAEE------------------ENEDVMFFKGGKDKDPQSSSAP KWPSSFS-PRGGKHVDR------------------------------TLAKGETE----- --------------------------------------------------PVIVLAPPRV ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------------G SPH--------------------------------------------------------- ----------------------DENAT--------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------PV-------------------------------------- -------------------KRPLSPP-A-------------------------------- ------------------------------------------------------------ ------------------------------G------------------SS--PRASHLP PRQPA-----------RSPA---------------------------ATPS--------- ---------------------------------PTVGTPAPPR----------------- --------------FTTRAPAPS------------------------------------- ----APT-T--------------------------------------------------- ------------------------------PML----------SLRQRMMN--------- ----S----------RFRNPF-----SRA-------------PV---------------- ------------------------------------------------------------ ---------------------------RPPS------R------P--------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------GYNGRPNG----------- --EGR---VLAGSNGKPSGQRIINGPQGTKWVVDLDRGLVLNAEGRYLQDSQGNPLRIKL GGDGRTIVDLGGTPVVSPDGLPLFGQGRHSKPLASAQDKPILSLGGKPLVGLE--VIKTT TRAP-IT-----TTRP-------------------------T--TTTPRPTTTPRPT--- --------TS-----PRPT----------------------------------------- ------T-TTTR-------PTTT-R--------TTTR-----------------RT--TT ----------TTPEP-------------TT------------------------------ -PIPTCPPGTLERHDKDGNLIM-GSRGVPECY--------------------------P- ------------------------EEDEFSGLETD--------TAVPTEEAYVIYDE--- ---------------------D--------YE-VE-TSG-------P-----P---P--- -------TTQSS-------------------------------------TTTTTTTTT-- TTPA-----------VIPPEGS----------------------I--------------- -----SSYPEEEFDLAGKKRFV--------------------------APYVTYLNKDPS APCSLTDALDHFQVDSLDEIIPND--LKKSDTPPQHVPRNITVVAVEGCHSFVIVDWDKA APGDTITGYLVYSASYEDFIRNKWSTQASSVTHLPIENLKPNT----------------- -------------RYYFRVQAKNPHGYGPVSSSVSFVTESDNPLLVVRPPG--------- ------GEPIWIPFAFKHDPSYTDCHGRQYVKRTWYRKFVGVVLCNSLRYKIYLSDNL-K -DTFYSIGDSWGRGEDHCQFVDSHLDGRTGPQSYIEALPNIQGYYRQYRQEPVSFGNIGF GTPYYYVGWYECGVSIPGKW---------------------------------------- ------------------------------------------------------ >ENSBIXP00000017888 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------------MA-------- ---PEVRASHRARRP-LPWAA-LLLLAALLPVVSPAGAAP-------------------- ------------------------------------------------ADHPL------- -----------------------KPRHVKLLSTKMGLKVTWDPPKDATNRSV----EHYN ------------------------------------------------------I-AYGK S-----------------------------------------------LK---------- -----------SLKYIKVNAETHSFLIEDV--------------------------EPGV VYFVLVTAENSN--------GVSRPVYRAESLP--------------------------- -------------------------------------------------------GG--- ---------------------------------EWIKIDGFPIKGPGP------------ ------------------FNETVT------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------EKDVPNKPLRVRVRSS-------------------------------------- -----------------DDRLSVAWKAPRL-SGAKS-------PR-RSRGFLLGYG---- -ESGRKMNY------------VPLTRDERTHEIKKL---ASESV---------------- ---------YVVSLQSMN-----------------SRGQSQPVYRAALTKRKISEE---- ---DELDVPEDINVRVMSSQSVLVAWVDPVLE-KQKKVV--AS-RQYTVRYREKGESARW DYKQVSNRRVLVENLSPDTMYEFAVRISQGERDGRWSTSVFQRTPESAPTSAPENLNVWP VNGKPTAVTVAWDALPETEGKVKEYILSYAPALKPFGAKSLTYPGETTSARVEGLQPGER YLFKIRAANRRGMGPHSKAFIVALPP-----------T-PTSESEVQQKTDREDQHKPEK PE----------------------------------------------PS-SSPKAPA-- -------PSKHTH-L--------------------------------------------- --------PVSPQGRNVKSPILDLKNKILANGGLLRKAQLPPRKNGGL---GLQS----T EITD-------EEEPDSRGDPPTSPPE-------------TQG----------------- -----------QKSQQRP--PSRPVHPFLAAGRTPVRARTPMLPRKEGVDQ-RGSSPTSH --------PR---------------------------------------PGAPPSASA-S -------------F--------SASR---------------------------------- ------------------------------------------------------PPP--- -------------------------------------------------------ESSTH ----------------RLSGGPS-----TSRPSSSTDN---------------------- ----------------------DSVGLEEEETTARSPPPKD------------------- ------------------------------------------------------------ ----------ALSEHLPGK----------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------------SAAHA----- -RPALSSGRHPAWSALRDRSAAHHGTRPALPA-------------------RRAP----- --------H-------------------------SEDREEGSRASAP------------- ------PSR---------------------------LSPSPGGSSRLLITEPQPGS---- -------PLSRGWKDGQDAPAARSN---------------APSG---------------- --------------STR------------------------------------------- ------------------------------------------------------------ PSSRTQASE------------------------------------------GAGGS--DG DGESDTEERGRPAAATAPTFRS---------RLPA------------------------- ----------GPPVSGHFSSLRNRPFAAHGRYPHRFGNGRGPRLHPSSS---PPS---TA SPRVH------------------------------------------------------- --------------------PRVDSHPAS------------------------------- DHRRGPGGQED-SE---------------------EEAEDEKPLP-------------AT ------------------------------------------------------------ ---------------------VVNHH-V------------S-----------------SS S------------------RQPASRGADHLRRGPQRGASLQRKEPLPENP---------- -------------------------------KST-------------------------- ----------------------------------------------------------GT W------------------------AGVPPQAK--------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------PPSSKAQDTQQS-TDAGAEGGSPKTQ -------LG-GRP----------------------------------------------- ---------------------------------------------------PAP------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------RSPH----------------- ------------------------------------------------------------ ---------------------------------------------------HQE-PTGPQ RM---------G----------AGSAALEKSPSLAVPASQ-PQPHGPRSKEVGRPPSRPQ PAFPSEAGRP---------------------HPTSQESASFSDSYSSRGGQSS------- ------------------------------------------------------------ --------------------------------RAASPQNLDDDSAEAGTGGVRAPAY--- -------------------SAGAKDATP-------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------SLPKHRQVDAQAGSAGDGHLRR----------PAG ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------R---------------------------------- ------------------------------------------------------------ ----------------PGSL--HPHA---------------------------------- -----------------------------------------------RTRVP-------- -------------------------------------------------------GRVGP QWAGRKDGASQASPA-------KREPLPS------------------------------- ----------KSQQSVSAEE------------------ENEDVMFFKGGKDKDPQSSSAP KWPSSFS-PRGGKHVDR------------------------------TLAKGETE----- --------------------------------------------------PVIVLAPPRV ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------------G SPH--------------------------------------------------------- ----------------------DENAT--------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------PV-------------------------------------- -------------------KRPLSPP-A-------------------------------- ------------------------------------------------------------ ------------------------------G------------------SS--PRASHLP PRQPA-----------RSPA---------------------------ATPS--------- ---------------------------------PTVGTPAPPR----------------- --------------FTTRAPAPS------------------------------------- ----APT-T--------------------------------------------------- ------------------------------PML----------SLRQRMMN--------- ----S----------RFRNPF-----SRA-------------PV---------------- ------------------------------------------------------------ ---------------------------RPPS------R------P--------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------GYNGRPNG----------- --EGR---VLAGSNGKPSGQRIINGPQGTKWVVDLDRGLVLNAEGRYLQDSQGNPLRIKL GGDGRTIVDLGGTPVVSPDGLPLFGQGRHSKPLASAQDKPILSLGGKPLVGLE--VIKTT TRAP-IT-----TTRP-------------------------T--TTTPRPTTTPRPT--- --------TT-----PRPT----------------------------------------- ------T-TTTR-------PTTT-R--------TTTR-----------------RT--TT ----------TTPEP-------------TT------------------------------ -PIPTCPPGTLERHDKDGNLIM-GSRGVPECY--------------------------P- ------------------------EEDEFSGLETD--------TAVPTEEAYVIYDE--- ---------------------D--------YE-VE-TSG-------P-----P---P--- -------TTQSS------------------------------------TTTTTTTTTT-- TTPA-----------VIPPEGS----------------------I--------------- -----SSYPEEEFDLAGKKRFV--------------------------APYVTYLNKDPS APCSLTDALDHFQVDSLDEIIPND--LKKSDTPPQHVPRNITVVAVEGCHSFVIVDWDKA APGDTITGYLVYSASYEDFIRNKWSTQASSVTHLPIENLKPNT----------------- -------------RYYFRVQAKNPHGYGPVSSSVSFVTESDNPLLVVRPPG--------- ------GEPIWIPFAFKHDPSYTDCHGRQYVKRTWYRKFVGVVLCNSLRYKIYLSDNL-K -DTFYSIGDSWGRGEDHCQFVDSHLDGRTGPQSYIEALPNIQGYYRQYRQEPVSFGNIGF GTPYYYVGWYECGVSIPGKW---------------------------------------- ------------------------------------------------------ >ENSBIXP00005034795 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------------MA-------- ---PEVRASHRARRP-LPWAA-LLLLAALLPVVSPAGAAP-------------------- ------------------------------------------------ADHPL------- -----------------------KPRHVKLLSTKMGLKVTWDPPKDATNRSV----EHYN ------------------------------------------------------I-AYGK S-----------------------------------------------LK---------- -----------SLKYIKVNAETHSFLIEDV--------------------------EPGV VYFVLVTAENSN--------GVSRPVYRAESLP--------------------------- -------------------------------------------------------GG--- ---------------------------------EWIKIDGFPIKGPGP------------ ------------------FNETVT------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------EKDVPNKPLRVRVRSS-------------------------------------- -----------------DDRLSVAWKAPRL-SGAKS-------PR-RSRGFLLGYG---- -ESGRKMNY------------VPLTRDERTHEIKKL---ASESV---------------- ---------YVVSLQSMN-----------------SRGQSQPVYRAALTKRKISEE---- ---DELDVPEDINVRVMSSQSVLVAWVDPVLE-KQKKVV--AS-RQYTVRYREKGESARW DYKQVSNRRVLVENLSPDTMYEFAVRISQGERDGRWSTSVFQRTPESAPTSAPENLNVWP VNGKPTAVTVAWDALPETEGKVKEYILSYAPALKPFGAKSLTYPGETTSARVEGLQPGER YLFKIRAANRRGMGPHSKAFIVALPP-----------T-PTSESEVQQKTDREDQHKPEK PE----------------------------------------------PS-SSPKAPA-- -------PSKHTH-L--------------------------------------------- --------PVSPQGRNVKSPILDLKNKILANGGLLRKAQLPPRKNGGL---GLQS----T EITD-------EEEPDSRGDPPTSPPE-------------TQG----------------- -----------QKSQQRP--PSRPVHPFLAAGRTPVRARTPMLPRKEGVDQ-RGSSPTSH --------PR---------------------------------------PGAPPSASA-S -------------F--------SASR---------------------------------- ------------------------------------------------------PPP--- -------------------------------------------------------ESSTH ----------------RLSGGPS-----TSRPSSSTDN---------------------- ----------------------DSVGLEEEETTARSPPPKD------------------- ------------------------------------------------------------ ----------ALSEHLPGK----------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------------SAAHA----- -RPALSSGRHPAWSALRDRSAAHHGTRPALPA-------------------RRAP----- --------H-------------------------SEDREEGSRASAP------------- ------PSR---------------------------LSPSPGGSSRLLITEPQPGS---- -------PLSRGWKDGQDAPAARSN---------------APSG---------------- --------------STR------------------------------------------- ------------------------------------------------------------ PSSRTQASE------------------------------------------GAGGS--DG DGESDTEERGRPAAATAPTFRS---------RLPA------------------------- ----------GPPVSGHFSSLRNRPFAAHGRYPHRFGNGRGPRLHPSSS---PPS---TA SPRVH------------------------------------------------------- --------------------PRVDSHPAS------------------------------- DHRRGPGGQED-SE---------------------EEAEDEKPLP-------------AT ------------------------------------------------------------ ---------------------VVNHH-V------------S-----------------SS S------------------RQPASRGADHLRRGPQRGASLQRKEPLPENP---------- -------------------------------QST-------------------------- ----------------------------------------------------------GT W------------------------AGVPPQAK--------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------PPSSKAQDTQQS-TDAGAEGGSPKTQ -------LG-GRP----------------------------------------------- ---------------------------------------------------PAP------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------RSPH----------------- ------------------------------------------------------------ ---------------------------------------------------HQE-PTGPQ RM---------G----------AGSAALEKSPSLAVPASQ-PQPHGPRSKEVGRPPSRPQ PAFPSEAGRP---------------------HPTSQESASFSDSYSSRGGQSS------- ------------------------------------------------------------ --------------------------------RAASPRNLDDDSAEAGTGGVRAPAY--- -------------------SAGAKDATP-------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------SLPKHRQVDTQAGSAGDGHLRR----------PAG ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------R---------------------------------- ------------------------------------------------------------ ----------------PGSL--HPHA---------------------------------- -----------------------------------------------RTRVP-------- -------------------------------------------------------GRVGP QWAGRKDGASQASPA-------KREPLPS------------------------------- ----------KSQQSVSAEE------------------ENEDVMFFKGGKDKDPQSSSAP KWPSSFS-PRGGKHVDR------------------------------TLAKGETE----- --------------------------------------------------PVIVLAPPRV ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------------G SPH--------------------------------------------------------- ----------------------DENAT--------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------PV-------------------------------------- -------------------KRPLSPP-A-------------------------------- ------------------------------------------------------------ ------------------------------G------------------SS--PRASHLP PRQPA-----------RSPA---------------------------ATPS--------- ---------------------------------PTVGTPAPPR----------------- --------------FTTRAPAPS------------------------------------- ----APT-T--------------------------------------------------- ------------------------------PML----------SLRQRMMN--------- ----S----------RFRNPF-----SRA-------------PV---------------- ------------------------------------------------------------ ---------------------------RPPS------R------P--------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------GYNGRPNG----------- --EGR---VLAGSNGKPSGQRIINGPQGTKWVVDLDRGLVLNAEGRYLQDSQGNPLRIKL GGDGRTIVDLGGTPVVSPDGLPLFGQGRHSKPLASAQDKPILSLGGKPLVGLE--VIKTT TRAP-IT-----TTRP-------------------------T--------TTTPRPT--- --------TT-----PRPT----------------------------------------- ------T-TTTR-------PTTT-R--------TTTR-----------------RT--TT ----------TTPEP-------------TT------------------------------ -PIPTCPPGTLERHDKDGNLIM-GSRGVPECY--------------------------P- ------------------------EEDEFSGLETD--------TAVPTEEAYVIYDE--- ---------------------D--------YE-VE-TSG-------P-----P---P--- -------TTQPSTT----------------------------------TTTTTTTTTT-- TTPA-----------VIPPEGS----------------------I--------------- -----SSYPEEEFDLAGKKRFV--------------------------APYVTYLNKDPS APCSLTDALDHFQVDSLDEIIPND--LKKSDTPPQHVPRNITVVAVEGCHSFVIVDWDKA APGDTITGYLVYSASYEDFIRNKWSTQASSVTHLPIENLKPNT----------------- -------------RYYFRVQAKNPHGYGPVSSSVSFVTESDNPLLVVRPPG--------- ------GEPIWIPFAFKHDPSYTDCHGRQYVKRTWYRKFVGVVLCNSLRYKIYLSDNL-K -DTFYSIGDSWGRGEDHCQFVDSHLDGRTGPQSYIEALPNIQGYYRQYRQEPVSFGNIGF GTPYYYVGWYECGVSIPGKW---------------------------------------- ------------------------------------------------------ >ENSBMUP00000003348 ------------------------------------------------------------ ------QMLASGLSLLSPQLRISLMALSFLSLMSPVSRL--------------------- ----------------------------------------------------QDS----- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------------DHPL------- -----------------------KPRHVKLLSTKMGLKVTWDPPKDATNRSV----EHYN ------------------------------------------------------I-AYGK S-----------------------------------------------LK---------- -----------SLKYIKVNAETHSFLIEDV--------------------------EPGV VYFVLVTAENSN--------GVSRPVYRAESLP--------------------------- -------------------------------------------------------GG--- ---------------------------------EWIKIDGFPIKGPGP------------ ------------------FNETVT------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------EKDVPNKPLRVRVRSS-------------------------------------- -----------------DDRLSVAWKAPRL-SGAKS-------PR-RSRGFLLGYG---- -ESGRKMNY------------VPLTRDERTHEIKKL---ASESV---------------- ---------YVVSLQSMN-----------------SRGQSQPVYRAALTKRKISEE---- ---DELDVPEDINVRVMSSQSVLVAWVDPVLE-KQKKVV--AS-RQYTVRYREKGESARW DYKQVSNRRVLVENLSPDTMYEFAVRISQGERDGRWSTSVFQRTPESAPTSAPENLNVWP VNGKPTAVTVAWDALPETEGKVKEYILSYAPALKPFGAKSLIYPGETTSARVEGLQPGER YLFKIRAANRRGMGPHSKAFIVALPP-----------S----------KHDTEDQHKPEK PE----------------------------------------------PS-SSPKAPA-- -------PSKHTH-L--------------------------------------------- --------PVSPQGRNVKSPLLDLKNKILANGGLLRKAQLPPRKNGGS---GLQS----T EITD-------EEEPDSRGDPPTSPPE-------------TQG----------------- -----------QKSQQRP--PSRPVHPFLAAGRTPVRARTPMLPRKEAVDQ-RVSSPTSH --------PR---------------------------------------PGAPPSASA-S -------------F--------SASR---------------------------------- ------------------------------------------------------PPP--- -------------------------------------------------------ESSTH ----------------RLSGGPS-----TSRPSSSTDN---------------------- ----------------------DSVGLEEEETTSRSPPRKD------------------- ------------------------------------------------------------ ----------ALSEHLPGK----------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------------SAAHA----- -RPALSSGRHPAWSALRDRSAAHHGTRPALPA-------------------RRAP----- --------H-------------------------SEDREEGSRASAP------------- ------PSR---------------------------LSPSPGGSSRLLITEPQPGS---- -------PLSRGWKDGQDAPAARSN---------------APSG---------------- --------------STR------------------------------------------- ------------------------------------------------------------ PSSRTQASE------------------------------------------GAGDS--DG DGES-------------------------------------------------------- -----------PPVSGHFSSLRNRPFAAHGRYPHRFGNGRGPRLHPSSS---PPS---TA SPRVH------------------------------------------------------- --------------------PRVDSHPAS------------------------------- DHRRGPGGQED-SE---------------------EEAEDEKPLP-------------AT ------------------------------------------------------------ ---------------------VVNHH-V------------S-----------------SS S------------------RQPASRGADHLRRGPQRGASLQRKEPLPENP---------- -------------------------------KST-------------------------- ----------------------------------------------------------GT W------------------------AGVPPQAK--------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------PPSSKAQDTQQS-TDAGAEGGSPKTQ -------LG-GRP----------------------------------------------- ---------------------------------------------------PAP------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------RSPH----------------- ------------------------------------------------------------ ---------------------------------------------------HQG-PTGPQ RM---------G----------AGSAALEKSPSSAVPASQ-PQPHGPRSKEVGRPPSRPQ PAFPSEAGRP---------------------HPTSQESASFSDSYSSRGGQSS------- ------------------------------------------------------------ --------------------------------RAASPQNLDDDSAEAGTGGVRAPAY--- -------------------SAGAKDATP-------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------SLPKHRQVDAQAGS--------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -WAGRKDGASQASPA-------KREPLPS------------------------------- ----------KSQQSVSAEE------------------ENEDVMFFKGGKDKDPQSSSAP KWPSSFS-PRGSKHVDG------------------------------TLAKGETE----- --------------------------------------------------PVIVLAPPRV ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------------G SPH--------------------------------------------------------- ----------------------DENAT--------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------PV-------------------------------------- -------------------KRPLSPP-A-------------------------------- ------------------------------------------------------------ ------------------------------G------------------SS--PRASHLP PRQP-------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------RMMN--------- ----S----------RFRNPF-----SRA-------------PV---------------- ------------------------------------------------------------ ---------------------------RPPS------R------P--------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------GYNGRPNG----------- --EGR---ALAGGNGKPSGQRLINGPQGTKWVVDLDRGLVLNAEGRYLQDSQGNPLRIKL GGDGRTIVDLGGTPVVSPDGLPLFGQGRHSKPLASAQDKPILSLGGKPLVGLE--VIKTT TRAP-IT-----TTRP-------------------------T--TTTP------------ ------------------------------------------------------------ ------------------------------------------------------RT--TT ----------TTPEP-------------TT------------------------------ -PIPTCPPGTLEQHDKDGNLIM-GSRGVPECY--------------------------P- ------------------------EEDEFSGLETD--------TAVPTEEAYVIYDE--- ---------------------D--------YE-VE-TSG-------P-----P---P--- -------TTQPS-------------------------------------TTTTTTTTT-- TTPA-----------VIPPEGS----------------------I--------------- -----SSYPEEEFDLAGKKRFV--------------------------APYVTYLNKDPS APCSLTDALDHFQVDSLDEIIPND--LKKSDTPPQHVPRNITVVAVEGCHSFVIVDWDKA APGDMITGYLVYSASYEDFIRNKWSTQASSVTHLPIENLKPNT----------------- -------------RYYFRVQAKNPHGYGPVSSSVSFVTESDNPLLVVRPPG--------- ------GEPIWIPFAFKHDPSYTDCHGRQYVKRTWYRKFVGVVLCNSLRYKIYLSDNL-K -DTFYSIGDSWGRGEDHCQFVDSHLDGRTGPQSYIEALPNIQGYYRQYRQEPVSFGNIGF GTPYYYVGWYECGVSIPGKW---------------------------------------- ------------------------------------------------------ >ENSBBBP00000002155 ------------------------------------------------------------ ------QMLASGLSLLSPQLRISLMALSFLSLMSPVSRL--------------------- ----------------------------------------------------QDS----- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------------DHPL------- -----------------------KPRHVKLLSTKMGLKVTWDPPKDATNRSV----EHYN ------------------------------------------------------I-AYGK S-----------------------------------------------LK---------- -----------SLKYIKVNAETHSFLIEDV--------------------------EPGV VYFVLVTAENSN--------GVSRPVYRAESLP--------------------------- -------------------------------------------------------GG--- ---------------------------------EWIKIDGFPIKGPGP------------ ------------------FNETVT------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------EKDVPNKPLRVRVRSS-------------------------------------- -----------------DDRLSVAWKAPRL-SGAKS-------PR-RSRGFLLGYG---- -ESGRKMNY------------VPLTRDERTHEIKKL---ASESV---------------- ---------YVVSLQSMN-----------------SRGQSQPVYRAALTKRKISEE---- ---DELDVPEDINVRVMSSQSVLVAWVDPVLE-KQKKVV--AS-RQYTVRYREKGESARW DYKQVSNRRVLVENLSPDTMYEFAVRISQGERDGRWSTSVFQRTPESAPTSAPENLNVWP VNGKPTAVTVAWDALPETEGKVKEYILSYAPALKPFGAKSLTYPGETTSARVEGLQPGER YLFKIRAANRRGMGPHSKAFIVALPP-----------S----------KHDTEDQHKPEK PE----------------------------------------------PS-SSPKAPA-- -------PSKHTH-L--------------------------------------------- --------PVSPQGRNVKSPLLDLKNKILANGGLLRKAQLPPRKNGGS---GLQS----T EITD-------EEEPDSRGDPPTSPPE-------------TQG----------------- -----------QKSQQRP--PSRPVHPFLAAGRTPVRARTPMLPRKEGVDQ-RGSSPTSH --------PR---------------------------------------PGAPPSASA-S -------------F--------SASR---------------------------------- ------------------------------------------------------PPP--- -------------------------------------------------------ESSTH ----------------RLSGGPS-----TSRPSSSTDN---------------------- ----------------------DSVGLEEEETTARSPPPKD------------------- ------------------------------------------------------------ ----------ALSEHLPGK----------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------------SAAHA----- -RPALSSGRHPAWSALRDRSAAHHGTRPALPA-------------------RRTP----- --------H-------------------------SEDREEGSRASAP------------- ------PSR---------------------------LSPSPGGSSRLLITEPQPGS---- -------PLSRGWKDGQDAPAARSN---------------APSG---------------- --------------STR------------------------------------------- ------------------------------------------------------------ PSSRTQASE------------------------------------------GAGGS--DG DGESDTEERGRPAAATAPTFRS---------RLPA------------------------- ----------GPPVSGHFSSLRNRPFAAHGRYPHRFGNGRGPRLHPSSS---PPS---TA SPWVH------------------------------------------------------- --------------------PRVDSHPAS------------------------------- DHRRGPGGQED-SE---------------------EEAEDEKPLP-------------AT ------------------------------------------------------------ ---------------------VVNHH-V------------S-----------------SS S------------------RQPASRGADHLRRGPQRGASLQRKEPLPENP---------- -------------------------------KST-------------------------- ----------------------------------------------------------GT W------------------------AGVPPQAK--------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------PPSSKAQDTQQS-TDAGEEGGSPKTQ -------LG-GRP----------------------------------------------- ---------------------------------------------------PAP------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------RSPH----------------- ------------------------------------------------------------ ---------------------------------------------------HQE-PTGPQ RM---------G----------SRSAALEKSPSSAVPASQ-PQPHGPRSKEVGRPPSRPQ PAFPSEAGRP---------------------HPTSQESASFSDSYSSRGGQSS------- ------------------------------------------------------------ --------------------------------RAASPQNLDDDSAEAGTGGVRAPAY--- -------------------SAGAKDATP-------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------SLPKHRQVDAQAGSAGDGHLRR----------PAG ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------R---------------------------------- ------------------------------------------------------------ ----------------PGSL--HPHA---------------------------------- -----------------------------------------------RTRVP-------- -------------------------------------------------------GRVGP QWAGRKDGASQASPA-------KREPLPS------------------------------- ----------KSQQSVSAEE------------------ENEDVMFFKGGKDKDPQSSSAP KWPSSFS-PRGGKHVDR------------------------------TLAKGETE----- --------------------------------------------------PVIVLAPPRV ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------------G SPH--------------------------------------------------------- ----------------------DENAT--------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------PV-------------------------------------- -------------------KRPLSPP-A-------------------------------- ------------------------------------------------------------ ------------------------------G------------------SS--PRASHLP PRQPA-----------RSPA---------------------------ATPS--------- ---------------------------------PTVGTPAPPR----------------- --------------FTTRAPAPS------------------------------------- ----APT-T--------------------------------------------------- ------------------------------PML----------SLRQRMMN--------- ----S----------RFRNPF-----SRA-------------PV---------------- ------------------------------------------------------------ ---------------------------RPPS------R------P--------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------GYNGRPNG----------- --EGR---VLAGSNGKPSGQRIINGPQGTKWVVDLDRGLVLNAEGRYLQDSQGNPLRIKL GGDGRTIVDLGGTPVVSPDGLPLFGQGRHSKPLASAQDKPILSLGGKPLVGLE--VIKTT TRAP-IT-----TTRP-------------------------T--TTTPRPTTTPRPT--- --------TT-----PRPT----------------------------------------- ------T-TTTR-------PTTT-R--------TTTR-----------------RT--TT ----------TTPEP-------------TT------------------------------ -PIPTCPPGTLERHDKDGNLIM-GSRGVPECY--------------------------P- ------------------------EEDEFSGLETD--------TAVPTEEAYVIYDE--- ---------------------D--------YE-VE-TSG-------P-----P---P--- -------TTQPS-----------------------------------------TTTTT-- TTPA-----------VIPPEGS----------------------I--------------- -----SSYPEEEFDLAGKKRFV--------------------------APYVTYLNKDPS APCSLTDALDHFQVDSLDEIIPND--LKKSDTPPQHVPRNITVVAVEGCHSFVIVDWDKA APGDMITGYLVYSASYEDFIRNKWSTQASSVTHLPIENLKPNT----------------- -------------RYYFRVQAKNPHGYGPVSSSVSFVTESDNPLLVVRPPG--------- ------GEPIWIPFAFKHDPSYTDCHGRQYVKRTWYRKFVGVVLCNSLRYKIYLSDNL-K -DTFYSIGDSWGRGEDHCQFVDSHLDGRTGPQSYIEALPNIQGYYRQYRQEPVNFGNIGF GTPYYYVGWYECGVSIPGKW---------------------------------------- ------------------------------------------------------ >ENSCHIP00000027916 -----------------------------------------M----------RIKAESPR LLILNIQMLSSGLSLLSPQLRISLMALGFLSVISPF------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------------S-------- ---P-------------------------------------------------------- -------------------------------------------------DHPL------- -----------------------KPRHVKLLSTKMGLKVTWDPPKDATSRSV----EHYN ------------------------------------------------------I-AYGK S-----------------------------------------------LK---------- -----------SLKYIKVNAETHSFLIEDV--------------------------EPGV VYFVLVTAENSN--------GVSRPVYRAESLP--------------------------- -------------------------------------------------------GG--- ---------------------------------EWIKIDGFPIKGPGP------------ ------------------FNETVT------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------EKDVPNKPLRVRVRSS-------------------------------------- -----------------DDRLSVAWKAPRL-SGAKS-------PR-RSRGFLLGYG---- -ESGRKMNY------------VPLTRDERTHEIKKL---ASESV---------------- ---------YVVSLQSMN-----------------SRGQSQPVYRAALTKRKISEE---- ---DELDVPEDINVRVMSSQSVLVAWVDPVLE-KQKKVV--AS-RQYTVRYREKGESARW DYKQASNRRVLVENLSPDTMYEFAVRISQGERDGRWSTSVFQRTPESAPTSAPENLNVWP VNGKPTAVTVAWDALPETDGKVKEYILSYAPALKPFGVKSLTYPGETTSARVEGLQPGER YLFKIRAANRRGLGPHSKAFIVALPP-----------T-PTSESDVQQKTDREDQHKPEK PE----------------------------------------------PS-SSAKAPA-- -------PSKHTH-L--------------------------------------------- --------PVSPQGRNVKSPLLDLKNKILANGGLLRKAQLPPRKNGGS---GLQS----T EITD-------EEEPDSRGDPPTSLPE-------------TQG----------------- -----------QKSQQRP--PSRPVHPFLAAGRTPVRARTPVLPRKEGVDQ-RGSSPTTH --------PR---------------------------------------PGA-------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------RPSSSTDN---------------------- ----------------------DSVGLEEEETTARSLPPKD------------------- ------------------------------------------------------------ ----------AL------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------------AAHA----- -RPALSSGRHPAWSALRDRSAAHHGTRPALPA-------------------RRAP----- --------H-------------------------SEDRGEASRASAP------------- ------PSR---------------------------LSPSPGGSSRLLITEPQPGS---- -------LLSRGWKDGQDMPAARSN---------------APSG---------------- --------------STR------------------------------------------- ------------------------------------------------------------ PSSRTQASE------------------------------------------GAGDS--DG DGDSDAEEGGRPAAATAPTFRS---------RLPA------------------------- ----------GPPVSGHFSSLRNRPFAAHGRYPHRFGNGRGARLHPSSS---PPS---TA SSRVH------------------------------------------------------- --------------------PRVDSHPAS------------------------------- DHRR-----ED-SE---------------------EEAEDEKPLP-------------AT ------------------------------------------------------------ ---------------------VVNHH-V------------S-----------------SS S------------------RQPASRGADHLRRGPQRGASLQRKEPLPENP---------- -------------------------------KST-------------------------- ----------------------------------------------------------GT W------------------------AGVPPQAK--------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------PPSSKAQDTQQS-TDAGAEGGS---- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------H----------------- ------------------------------------------------------------ ---------------------------------------------------HPG-PTGPQ RM---------G----------AGSAALEKSPSSAVPASQ-PQPHGPRIKEVGRPLSRPQ PAFPSEAGRP---------------------HPTSQESSSFSDSYSSRGGQSS------- ------------------------------------------------------------ --------------------------------RAVSPQNLDNDSAEARTGGVRAPAY--- -------------------SAGAKDATP-------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------SLPKHRQVDAQAGSAGDGHLRR----------PAG ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------R---------------------------------- ------------------------------------------------------------ ----------------PGSL--HPYA---------------------------------- -----------------------------------------------RTRVP-------- -------------------------------------------------------GRA-- --------------A-------KREPLPS------------------------------- ----------KSQQSVSAEE------------------EDEDVMFFKGGKDKDPQSSSAP KWPSSFS-PRGGKQVDG------------------------------TLAKGETE----- --------------------------------------------------PAIVLAPPR- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------ENAT--------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------PV-------------------------------------- -------------------KRPLSPP-A-------------------------------- ------------------------------------------------------------ ------------------------------G------------------SP--PRASHLP PRQPT-----------RSPA---------------------------ATPS--------- ---------------------------------PTVGTPAPSR----------------- --------------FTTRAPAPS------------------------------------- ----APT-T--------------------------------------------------- ------------------------------PML----------SLRQRMMN--------- ----A----------RFRNPF-----SRA-------------PV---------------- ------------------------------------------------------------ ---------------------------RPPS------R------A--------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------GYNGRPNG----------- --EGR---VLAGSNGKPSGQRIINGPQGTKWVVDLDRGLVLNAEGRYLQDSQGNPLRIKL GGDGRTIVDLGGTPVVSPDGFPLFGQGRHAKPLASAQDKPILSLGGKPLVGLE--VIKTT TRAP-IT-----TTRP-------------------------T--TTTTR-----RPT--- --------TT-----PRPT----------------------------------------- ------T-TTTR-------PTTT-R--------TTTQ-----------------RT--TT ----------TTPEP-------------TT------------------------------ -PVPTCPPGTLERHDEDGNLIM-GSRGVPECY--------------------------P- ------------------------EEDEFSGLETD--------TAVPTEEAYVIYDE--- ---------------------D--------YE-VE-TSG-------P-----P---P--- -------TTQPSTT----------------------------------TTTTTTTTTT-- TTPA-----------VIPPEGS----------------------I--------------- -----SSYPEEEFDLAGKKRFV--------------------------APYVTYLNKDPS APCSLTDALDHFQVESLDEIIPND--LKKSDTPPQHVPRNITVVAVEGCHSFVIVDWDKA APGDVITGYLVYSASYEDFIRNKWSTQASSVTHLPIENLKPNT----------------- -------------RYYFKVQAKNPHGYGPVSSSVSFVTESDNPLLVVRPPG--------- ------GEPIWIPFAFKHDPGYTDCHGRQYVKRTWYRKFVGVVLCNSLRYKIYLSDNL-K -DTFYSIGDSWGRGEDHCQFVDSHLDGRTGPQSYIEALPNIQGYYRQYRQEPVSFGNIGF GTPYYYVGWYECGVSIPGKW---------------------------------------- ------------------------------------------------------ >ENSOARP00000004808 -----------------------------------------SERIYGLFLLSD------- ------------------QLRISLMALGFLSVISPF------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------S-------------------- ----------------------------------------VDSCAVCIADHPL------- -----------------------KPRHVKLLSTKMGLKVTWDPPKDATSRSV----EHYN ------------------------------------------------------I-AYGK S-----------------------------------------------LK---------- -----------SLKYIKVNAETHSFLIEDV--------------------------EPGV VYFVLVTAENSN--------GVSRPVYRAESLP--------------------------- -------------------------------------------------------GG--- ---------------------------------EWIKIDGFPIKGPGP------------ ------------------FNETVT------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------EKDVPNKPLRVRVRSS-------------------------------------- -----------------DDRLSVAWKAPRL-SGAKS-------PR-RSRGFLLGYG---- -ESGRKMNY------------VPLTRDERTHEIKKL---ASESV---------------- ---------YVVSLQSMN-----------------SRGQSQPVYRAALTKRKISEE---- ---DELDVPEDINVRVMSSQSVLVAWVDPVLE-KQKKVV--AS-RQYTVRYREKGESARW DYKQASNRRVLVENLSPDTMYEFAVRISQGERDGRWSTSVFQRTPESAPTSAPENLNVWP VNGKPTAVTVAWDALPETDGKVKEYILSYAPALKPFGVKSLTYPGETTSARVEGLQPGER YLFKIRAANRRGLGPHSKAFIVALPP-----------T-PTSESDVQQKTDTEDQHKPEK PE----------------------------------------------PS-SSPKAPA-- -------PSKHTH-L--------------------------------------------- --------PVSPQGRNVKSPLLDLKNKILANGGLLRKAQLPPRKNGGS---GLQS----T EVTD-------EEEPDSRGDPPTSPPE-------------TQG----------------- -----------QKSQQRP--PSRPVHPFLAAGRTPVRARTPVLPRKEGVDQ-RGSSPTSH --------PR---------------------------------------PGAPPSASG-S -------------S--------SASR---------------------------------- ------------------------------------------------------PPP--- -------------------------------------------------------ESSAH ----------------HLSGGHS-----TSRPSSSTDN---------------------- ----------------------DSVGLEEEETTARSPPPKD------------------- ------------------------------------------------------------ ----------ALSEHLPGK----------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------------SAAHA----- -RPALSSGRHPAWSALRDRSAAHHGTRPALPARG----------AAH---SRRAP----- --------H-------------------------SEDREEGSRASAP------------- ------PSR---------------------------LSPSPGGSSRLLITEPQPGS---- -------LLSRGWKDGQDMPAARSN---------------APSG---------------- --------------STR------------------------------------------- ------------------------------------------------------------ PSSRTQASE------------------------------------------GAGDS--DG DGDSDAEEGGRPAAATAPTFRS---------RLPA------------------------- ----------GP--------LRNRPFAAHGRYPHRFGNGRGARLHPSSS---PPS---TA SSRAH------------------------------------------------------- --------------------PGVDSHPAS------------------------------- DHRRGPGGQED-SE---------------------EEAEDEKPLP-------------ST ------------------------------------------------------------ ---------------------VVNHH-V------------S-----------------SS S------------------RQPASRGADHLRRGPQRGASLQRKERLPENP---------- -------------------------------KST-------------------------- ----------------------------------------------------------GT W------------------------AGVPPQAK--------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------PPSSKAQDTQQS-TDAGAEGGSPETQ -------LG-GRP----------------------------------------------- ---------------------------------------------------PAP------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------RSPH----------------- ------------------------------------------------------------ ---------------------------------------------------HPGAPGAPK RM---------G----------AGSAALEKSPSSAVPASQ-PQPHGPRIKEVGRPPSRPQ PAFPSEAGRL---------------------HPTSQESSSFSDSYSSRGGQSS------- ------------------------------------------------------------ --------------------------------RAASPQNLDDDSTEARTGG--------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------------APG------- -----------------------------------------------------LAGRAGP QWVGRKDGASQASPA-------KREPLPS------------------------------- ----------KSQQSVSA-E------------------EDEDVMFFKAGKDKDPQSSSAP KWPSSFS-PRGGKQVDG------------------------------TLAKGETE----- --------------------------------------------------PAIVLAPPRV ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------------G SPH--------------------------------------------------------- ----------------------DENAT--------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------PV-------------------------------------- -------------------KRPLSPP-A-------------------------------- ------------------------------------------------------------ ------------------------------G------------------SP--PRASHLP PRQPTLQPQPP----PR------------------------------------------- -------------------------------------TPAPSR----------------- --------------FTTRAPVPS------------------------------------- ----APT-T--------------------------------------------------- ------------------------------PML----------SLRQRMMN--------- ----A----------RFRNPF-----SRA-------------PV---------------- ------------------------------------------------------------ ---------------------------RPPS------R------A--------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------GYNGRPNG----------- --EGR---VLAGSNGKPSGQRVINGPQGTKWVVDLDRGLVLNAEGRYLQDSQGNPLRIKL GGDGRTIVDLGGTPVVSPDGFPLFGQGRHAKPLASAQDKPILSLGGKPLVGLE--VIKTT TRAP-IT-----TTRP-------------------------T--TTTTR-----RPT--- --------TT-----PRPT----------------------------------------- ------T-TTTR-------PTTT-R--------TTTQ-----------------RT--TT ----------TTPEP-------------TT------------------------------ -PVPTCPPGTLERHDEDGNLIM-GSRGVPECY--------------------------P- ------------------------EEDEFSGLETD--------TAVPTEEAYVIYDE--- ---------------------D--------YE-VE-TSG-------P-----P---P--- -------TTQPSTT----------------------------------TTTTT------- ------------------------------------------------------------ ------SYPEEEFDLAGKKRFV--------------------------APYVTYLNKDPS APCSLTDALDHFQVESLDEIIPND--LKKSDTPPQHVPRNITVVAVEGCHSFVIVDWDKA APGDVITGYLVYSASYEDFIRNKWSTQASSVTHLPIENLKPNT----------------- -------------RYYFKVQAKNPHGYGPVSSSVSFVTESDNPLLVVRPPG--------- ------GEPIWIPFAFKHDPGYTDCHGRQYVKRTWYRKFVGVVLCNSLRYKIYLSDNL-K ADTFYSIGDSWGRGEDHCQFVDSHLDGRTGPQSYIEALPNIQGYYRQYRQEPVSFGNIGF GTPYYYVGWYECGVSIPGKW---------------------------------------- ------------------------------------------------------ >ENSSSCP00000056913 -------------F---------------------------------------------- -------------------------------------KL--------------------- -------------------------------------------------AAPIDSCAVY- ------------------------------------------------------------ --------------------------------------------------I--------- ------------------------------------------------------------ ------------------------------------------------ADHPL------- -----------------------KPRHVKLLSTKMGLKVTWDPPKDATSRPV----EHYN ------------------------------------------------------I-AYGK S-----------------------------------------------LK---------- -----------SLKYIKVNAETHSFLIEDV--------------------------EPGV VYFVLVTAENSK--------GVSRPVYRAESLP--------------------------- -------------------------------------------------------GG--- ---------------------------------EWIKMDGFPIKGPGP------------ ------------------FNETVP------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------EKDVPNKPLRVRVRSS-------------------------------------- -----------------DDRLSVAWKAPRM-SGAKS-------PR-RSRGFLLGYG---- -ESGRRMNY------------VPLTRDERTHEIKKL---ASESV---------------- ---------YVVSLQSMN-----------------SRGQSQPVYRAALTKRKISEE---- ---DDLGVPEDINVRVMSSQSVLVAWVDPALE-KQKKVV--AS-RQYTVRYREKGESARW DYKQISNRRVLVESLIPDTMYEFAVRISQGERDGKWSTSVFQRTPESAPTTAPENLKVWP VNGKPTAVTVAWDALPETEGKVKEYILSYAPALKPFGAKSLTYPGETTSALVDGLQPGER YLFKIRAANRRGLGPHSKAFVVAMP------------------------ANAEDDEKPEK PE----------------------------------------------PS---------- -------SSKDTL-L--------------------------------------------- --------SVSPQGRNVKNALLDLKNKILANGGLPRKPQLPPRKTEGL---DLQS----T EITD-------EEELDSRGDPPTSPSE-------------TQE----------------- -----------QKPQQRP--PSRSLHPVLAPGRTPLRARTPVL----------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------STDN---------------------- ----------------------DSVGQGEEEPAAGSPHPKD------------------- ------------------------------------------------------------ ----------AASQQPPPK----------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------------SAAVA----- -RPAVSPSRQPPWNALRE------GAKPALPA-------------------RRAP----- --------H-------------------------SEAGEGNSRASAP------------- ------SSR---------------------------LSPAHGGSSRLLPTQPHPGSP--- -------PLSWGWKDGHEAPAVKSN---------------APSRSTKP------------ -----------SSASSR------------------------------------------- ------------------------------------------------------------ LTSRTQVTE------------------------------------------EAEDS--DE DGDNEAEEKGRQAEATAPTFRA---------RLPA------------------------- ----------GSPVSGHFSLLRSRPFAAHGRYPHGFGSGRGPRLQPSSS---PPS---TL SPRGH------------------------------------------------------- --------------------SRVSSHPAS------------------------------- DRRPGSTVHEDSEE---------------------REAEDEKPLP-------------ST ------------------------------------------------------------ ---------------------VVNEP-M------------P-----------------SS S------------------RQPTSRVADHLRRGPQRGQSLQRKEPLAENP---------- -------------------------------KSA-------------------------- ----------------------------------------------------------GT W------------------------AGAHPQAK--------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------SPSSKAQDAHQS-TDAGAEGGSPKTQ -------MVPARP----------------------------------------------- ---------------------------------------------------PTA------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------RSQH----------------- ------------------------------------------------------------ ---------------------------------------------------HPA-SSVTK RL---------G----------AGS----------------------------------- ------------------------------------ESASFSDPYSSRGKQPSLTASS-- --------------------REVLSKSP-------------------------------- ------QNPNEDSESG------NHDDSAEAAPRA-------------------------- --------------------AGAKDASP-------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------ALPKHRQV----GAPGDGHLRR----------PPA ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------R---------------------------------- ------------------------------------------------------------ ----------------AGSP--HPYA---------------------------------- -----------------------------------------------RTRVP-------- -------------------------------------------------------GRAGT QTVGKKDVASPAAAS-------KREPLRA------------------------------- ----------KSQQSVSAEE------------------EDEDVMFFKGGKDKDSLSSSAP KWPSSFI-PRGSKHADR------------------------------SIAKGDL------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -PW--------------------------------------------------------- ----------------------DENAT--------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------PV-------------------------------------- -------------------KRPPPPPRP-------------------------------- ------------------------------------------------------------ ------------------------------G------------------SS--PRASHLP PRQPP-----------RSP----------------------------ATPS--------- ---------------------------------PTVGTPAPPR----------------- --------------FTTRAPATY------------------------------------- ----SST-T--------------------------------------------------- ------------------------------PML----------SLRQRMMN--------- ----A----------RFRNPL-----SRA-------------PV---------------- ------------------------------------------------------------ ---------------------------RPPS------R------Q--------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------GYNGRSNG----------- --EGK---VLPGSNGHPSGQRIINGPQGTKWVVDLDRGLVLNAEGRYLQDSQGNPLRIKL GGDGRTIVDLGGTPVVSPDGLPLFGQGRHSKPLASAQDKPILSLGGKPLVGLE--VIKTT TQAP-T------------------------------------------------------ ------------------------PP---PHHHPHHHHHHAAHHTTTPRAHHPRPHL--- ------------------------------------------------------------ ------------------------------------------------------------ ------PPGTLERHDEDGNLVM-GSSGVPECD--------------------------P- ------------------------EEDEFSGLETD--------TEVPTEEAYVIYDE--- ---------------------D--------YE-FE-TSK-------PPATTQP---S--- -------TTRPA-------------------------------------------TTA-- TTPA-----------VIPPEGS----------------------I--------------- -----SSYPEEEFDLAGKKRFV--------------------------APYVTYLNKDPS APCSLTDALDHFQVESLDEIIPND--LKKSDLPPQHVPRNITVVAVEGCHSFVIVDWDKA APGDMITGYLVYSASYEDFIRNKWSTQASSVTHLPIENLKPNTRYNVSVIYQKRERPVGP FECSLSKMFSSNFRYYFKVQAKNPHGYGPVSPSVSFITESDNPLLVVRPPG--------- ------GEPIWIPFAFKHDPSYTDCHGRQYVKRTWYRKFVGVILCNSLRYKIYLSDNL-K -DTFYSIGDSWGRGEDHCQFVDSHLDGRTGPQSYIEALPTIQGYYRQYRQEPVSFGSIGF GTPYYYVGWYECGVTIPGKW---------------------------------------- ------------------------------------------------------ >ENSOCUP00000012938 -----------------------------------------MQR---------------- ------------------------------------------------------------ -------------K--------------------------CH------------------ ---------------------DPSILII-------------------------------- ------------------------------------------------------------ ----------------------LLLLA--------------------------------- ----------------MSGATRT------------------------VLDHPL------- -----------------------KPRRVKLLSSKLGLKVTWEPPRDAASRPV----EHYN ------------------------------------------------------I-AYGK S-----------------------------------------------LK---------- -----------SLKYVKVNAEASSFLTEDV--------------------------EPGV VYFVLVTAENHS--------GVSRPVYRAESLP--------------------------- -------------------------------------------------------GG--- ---------------------------------EWIKIDGFPIKGPGA------------ ------------------FNETIT------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------EKEVPNKPLRVRVRSS-------------------------------------- -----------------DDRLSVAWKAPRL-SGAKS-------PR-RSRGFLLGYG---- -ESGRKMNY------------VPLTRDERSHEIKKL---ASESV---------------- ---------YVVSLQSVN-----------------SQGQSQPVYRAALTKRKISEE---- ---DELDVPRDISVRVMSSQSVLVAWVDPAVE-KQKKVV--AS-RQYTVRYREKGESARW DYKQTANRRALIESLIPDTVYEFAVRISQGERDGKWSTSVFQRTPESAPTTAPENLRVWP VNGKPTVVTASWDALPETEGKVKEYILSYAPALKPFGAKSLTYPRGTTSALVDGLQPGER YLFKIRAANRRGPGPPSKAFIVAMPA-----------A-SAAERDAAQ--STVENWKPQS PA----------------------------------------------APSPPPQTPA-- -------PSGHTR-V--------------------------------------------- --------PASPRGSKAKDLLLDLKNKILANGGLLRKPQLRPRKTGEP---DPQS----T EVTQ-------EEEPDSLEDPRTTPLQ-------------TQE----------------- -----------HRQTLRP--LSRPGHPALVPGRTPARARVPGPPRQEGVHR-RG------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------QGAHHTAPQGTPDRAAAGP----- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------T-------------- ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------APSQPTVP------------ -----------SPASSR------------------------------------------- ------------------------------------------------------------ FSSRTQ-----GSRGGSDGDNGDVG-DSRRQDPV-------------------------- ---------------TAPTARA---------R---------------------------- ------------PASGHLSLLRNRPFAAHGRFPSRLGGGRGLRLQPSRS---PQA---TV ASPAH------------------------------------------------------- --------------------SRAHPQPAS------------------------------- HPWPGSSVHTE--------------------------EEDEQPLP-------------AT ------------------------------------------------------------ ---------------------VVHDH-V------------P-----------------SS S------------------RQPTSRGGEPLRRGPQRGASLYHKEAIPESP---------- -------------------------------KSA-------------------------- ----------------------------------------------------------GT --------------------------VMHPQDKT-------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------AALTHKTLDAQQS-TDVDEELRSPQTR PVSNGHRLPPARP----------------------------------------------- ---------------------------------------------------PAS------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------STPGPASSRAVLHTASPRGDLQSSSGSMDGSTQVA GQAFPHQ----------------------------------------------------- -------------------------ATPH------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------DRGAQ-----------------------R A----------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------------------PAG SSP--------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------R---------------------------------- ------------------------------------------------------------ ----------------PGWP---------------------------------------- -------------------------------------------------RSP-------- -------------------------------------------------------SRTG- ---------VQATP--GQKEALSKRPLLS------------------------------- ----------KSQQSVSAEEK-------------EEE-EEEDAGYLKGGKE-APLPPSVS KWPSATS-PRGGKYTKD------------------------------------------- ---------RM------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------PP-P-------------------------------- ------------------------------------------------------------ ------------------------------G------------------ST--PRTPQPP TGHPP-----------RSP----------------------------AVSAS-------S RP-----------------------------WPP-------------------------- ----------------TRAPPDF------------------------------------- ----SST-T--------------------------------------------------- ------------------------------PML----------SLRQRMQR--------- ---------------RFRTPG-----SRQ-------------PP---------------- ------------------------------------------------------------ ---------------------------RSLH------T------Q--------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------GYNGRPNA----------- --EGR---VLPGSNGKPNGQRIINGPQGTKWVVDLDRGLVLNAEGRHLQDSHGNPLRVKL GGDGRTIVDLSGTPVVSPDGLPLFGQGRHGKPLASAQDKPILSLGGKPLVGLE--VVKTT TLPP-TT-----TRRL---------TTTTTPLP-----------VTTPRPT-----T--- --------TT-----TRRT--TTTT-------------------------------RRMT TTTRRTT-TTTR-------PTTTTRPTRRTTTTTTTT-----------------TT--TT ----------TTPEP-------------TT------------------------------ -SPPTCPPGTLEQHDDDGNLIM-GSNGIPECY--------------------------P- ------------------------EEDDFSGLETD--------TAIPTEEAYVVYDE--- ----GARRLRHPA---------------------------------------P---A--- -------------EDLMTPRMVSLAETGSVSLPPEKVVSNVTGCRCSLP----------- ------------------------------------------------------------ ------------------------------------------------APYVTYLSKDPA APCSLTDALDHFQVESLDEIIPHD--LKKNDLPPQHVPRNITVVAMEGCHSFVIVDWDKA SPGDVVTGYLVYSASYEDFIRNKWSTQASSVTHLPIENLKPNT----------------- -------------RYYFKVQAKNPHGYGPISPSVSFVTESDNPLLVVRPPG--------- ------GEPIWIPFAFKHDPSYTDCQGRQYVKRTWYRKFVGVVLCNSLRYKIYLSDNL-K -DTFYSIGDSWGRGEDHCQFVDSHLDGRTGPQSYVEALPAIQGYYRQYRQEPVSFGQIGF GTPYYYVGWYECGVSIPGKW---------------------------------------- ------------------------------------------------------ >ENSMOCP00000009284 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------------MA-------- ---PEAGA---SPRP-LPWAA-LLLLAALLPVASSAG-PP-------------------- ------------------------------------------------ADHPL------- -----------------------KPRHVRLLSTKVGLKVAWDPPKDATSRPV----EHYN ------------------------------------------------------I-AYGK S-----------------------------------------------LK---------- -----------SLKYIKVNAETNSFLIEDV------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------EKEVPNKPVRMRVRAS-------------------------------------- -----------------DDRLSVAWKAPRL-SGAKS-------PR-RSRGFLLGYG---- -ESGRKMNY------------VPLTRDERSHEIKKL---ASESV---------------- ---------YVVSLQSTN-----------------SQGQSQPVYRAALTKRKNSED---- ---SELDVPEDISVRVMSSQSVLVAWVDPLVE-KQKRVV--AS-RQYTVRYREKGESARW DYKQVSNRRVLVDNLIPDTVYEFAVRISQGERDGKWSASIFQRTPESAPTTAPENLNVWP VSGKPTVVTVSWDALPETEGKVKEYILSYAPALKPFGAKSLTFSGHTTSALVDGLQPGER YLFKIRATNRRGPGPHSKAFIVTIPT-----------T-SSPEASVHQ--DGRNIRKPEK PQ----------------------------------------------PSPFTPKTAA-- -------SSEHT------------------------------------------------ -----------PPAKNAMDDLLDLKNKILANGVPPRKTQLHS-KMGEL---DPQT----T DVNG-------EEELDSLEDPRPSRVE-------------TLD----------------- -----------RRRPLRV--PSRSGHWVPAPGRTPARTGLPVLPRKEGMDR-RGTSLVPH --------PH---------------------------------------PRVESSVTSVS -------------ST--------------------------------------------- -------------------YTQLSS----------------------------------- ------------------------------------------------------------ -----------------------------------TDN---------------------- ----------------------DSMNQNEDDQE---------VSPD-------------- ------------------------------------------------------------ -----------------PK----------------------------------------- ---------------AASYQT-TKNP---------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------VGSKPTAT----------- ------PRHHVASDTLRDKSRLLPGAKA------EWSASRRSQSSTS------------- --------------------------------------EEDSSVAAQ------------- ------PLG---------------------------HGPLHRGSSR-----PHSRS---- -------QLSRGWKDRQDA----------------------PSHAAVSPSGSSRPFSLAE GSEEEDT----------------------------------------------------- ------------------------------------------------------------ -------------------------------------------------------SDGGG DVDRDAGDTRRQAEVTAQTQQT---------R---------------------------- ------------PALGHFSLTRNKPFSAHSRNPNRFPRFRGLRLQPSGS---PQS---TS TPKVL------------------------------------------------------- --------------------TRSPSQSAS------------------------------- HTR--SNVYGD--------------------------GEDEEPLP-------------AT ------------------------------------------------------------ ---------------------VVNNR-T------------P-----------------SS S------------------RHPASGGWDTLRRGPQRGTSLYRKDPIPENP---------- -------------------------------KAA-------------------------- ----------------------------------------------------------GA --------------------------DAHPGGK--------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------SPLSSKAQDFEQR-TNEDA----HQTS PGSTSRQLPPARL----------------------------------------------- ---------------------------------------------------PAP------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------RSQP----------------- ------------------------------------------------------------ ---------------------------------------------------FPG-STVPR RMTSGRSSEVS----------------------------------SSQSKSD-------- ------------------------------------------------------------ ---------------ESGRDR--------------------------------------- ------------------------------------------------------------ ---------------------------SHT-----------------------------M NS--------------------HGVLSSASQSQ--------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -D---------------------------------------------------------- ----------EESQS--------------------------------------------- ---------------------------SYEENST-------------------------- ---------------EIETPDSRTLTHSAR------------------------------ --------------------------------------AKD------------------- ------------------------------------------------------------ ----------------------ATPSTFRHRQV--------------------------- ------GSQIGN---SDSSPQPSH------------------------------------ ------------------------------------------------------------ ------------------------------------------------TRAS-------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------VRPSR---------------------------------- ------------------------------------------------------------ ----------------P------------------------------------------- -----------------------GS-------------------PHPRAQVP-------- -------------------------------------------------------GRAG- ---------FQATP--VKKISPSKGPLPP------------------------------- ----------ESLQSVFTEEE-------------EEE-EEEKEGLLK-GKE-DSLST--S KWPSSSS-HRGNKYADR-NFDKDRAAG--------------------------------- -------------------G------------------SLVQEANAI------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------PG-------------------------------------- -------------------RR----P-P-------------------------------- ------------------------------------------------------------ ------------------------------G------------------SP--SIATHPP PRYQP-----------RNP----------------------------ATAS--------- ---------------------------------PMASTHSWPR----------------- --------------YTTHAPPSY------------------------------------- ----SST-T--------------------------------------------------- ------------------------------PML----------SLRQRMQR--------- ---------------RFRTPV-----SRH-------------PP---------------- ------------------------------------------------------------ ---------------------------RPVL------A------Q--------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------GYNGRPNV----------- --EEN---IPPGSVGKPNRQKIINGPQGTKWVVDLDRGLVFNAEGRYLQDSLGNPLRVRL GGDGRTIVDLGGTPMVSPDGLPLFGQGRHGKPLASAQDKPILSLGGKPLVGLE--VIRTT THPP-TT-----TMPP---------TTTTTTVP--------T--TTTLQPQTT---TT-- --HR----TT-----TRRTTTTTT------------------------------------ ---RRTT-TTRR-------PTTTIR--------ATRR----------------TTT--TT ----------TTPEP-------------TT------------------------------ -LSPTCPPGTVEQQDEAGNLIM-GANGIPECY--------------------------P- ------------------------EEDDFSGLDTD--------TASPTDVGYAVYDD--- ---------------------D--------YG-FE-TTR-------P-----P---T--- -------TIIPS-------------------------------------------TTA-- ATPK-----------VIPEQGT----------------------V--------------- -----SSFPEEEFDLAGKKRFV--------------------------APYVTYLSKDPS APCSLTDALDHFQVESLDELIPND--LTKNELPPQHAPRNITVVAMEGCHSFVIVDWNKA IPGDVVTGYLVYSASYEDFIRNKWSTQTSSVTHLPIENLKPNT----------------- -------------RYYFKVQAKNPHGYGPVSPSVSF---------------FVSDSPWNP LYLRACGEPIWIPFAFKHDPSNTDCHGRQYVKRTWYKKFVGVILCNSLRYKIYLSDNL-K -DTFYSIGDSWGRGEDHCQFVDSHLDGRTGPQSYVEALPTIQGYYRQYRQEPVSFGNIGF GTPYYYVGWYECGVSIPGKW---------------------------------------- ------------------------------------------------------ >ENSCGRP00015015283 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------MGLKVTWDPPKDATSRPV----EYYN ------------------------------------------------------I-AYGK S-----------------------------------------------LK---------- -----------SLKYIKVNSETNSFLIEDV------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------EKEVPNKPVRLRVRAS-------------------------------------- -----------------DDRLSVAWKAPRL-SGAKS-------PR-RSRGFLLGYG---- -ESGRKMNY------------VPLTRDERSHEIKKL---ASESV---------------- ---------YVVSLQSTN-----------------SQGQSQPVYRAALTKRKNSED---- ---SELDLPEDISVRVMSSQSVLVAWVDPLVE-KQKRVV--TS-RQYTVRYREKGESARW DYKQVSNRRALVDGLLPDTVYEFAVRISQGERDGKWSASIFQRTPESAPTIAPENLNVWP VSGKPTAVTVSWDALPETEGKVKEYILSYAPALKPFGAKSLTFSGHTTSAMVDGLQPGER YLFKIRATNRRGPGPHSKAFIVTIPT-----------T-SSTEASAHQ--NGGNSWKPEQ SQ----------------------------------------------PSSPAPKAAT-- -------SSEHT------------------------------------------------ -----------PPAKNAKDVLLDLKNKILANGGPPRKTHLHS-KMGAL---DPQ------ EVTG-------EEELDSLEDPRPAQSE-------------TLD----------------- -----------QRRPLRI--PSRPGHRVLAPGRTPARAGLPVLPRKEGMDR-GGPSLVPY --------PR---------------------------------------SGAEPSVTA-S -------------S---------------------------------------------- -------------------------TH---------------------------P----- ------------------------------------------------------------ ----------------------------------ITDN---------------------- ----------------------DSVSQNEHDQE---------GSPD-------------- ------------------------------------------------------------ -----------------PK----------------------------------------- ---------------AASSQS-PNNP---------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------VGSKPTPT----------- ------PSRHVASNMLRDKSRMLPGAKA------ESSASRNSHSSTS------------- --------------------------------------EEDSSAAAQ------------- ------PSG---------------------------HFPLHRGSSR-----PHSRS---- -------QLSRGLKDRQDAPASGSH---------------TPSRTAVSPSGSSHPFSQTE GSEEEDT----------------------------------------------------- ------------------------------------------------------------ -------------------------------------------------------SDGWG DGDRDAGDTRRQAEATAQTQQT---------R---------------------------- ------------PALGHFSLTRNKPFATHSRNPNRFPRFRGLRLHPSVS---PQS---TS ASKVL------------------------------------------------------- --------------------TRAPSQPTS------------------------------- HTRPSPDVYGG--------------------------GEDEEPLP-------------AT ------------------------------------------------------------ ---------------------VVNDR-S------------P-----------------SS S------------------RHPASGGWDTLRRGPQRGASLYRKEPIPENP---------- -------------------------------KTA-------------------------- ----------------------------------------------------------GA --------------------------DVHPGGK--------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------SPLSSKAQDLQQS-THEDA----RRTS PGSTSRQLPPARL----------------------------------------------- ---------------------------------------------------PAS------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------RSQP----------------- ------------------------------------------------------------ ---------------------------------------------------FPG-STVPR RLAPSRSSEIS----------------------------------SSQSKDSDRSLSQPK LMPD-------------------------------------------------------- ---------------HTGRDR--------------------------------------- ------------------------------------------------------------ ---------------------------SHT-----------------------------L NS--------------------RGMLPSASQSQ--------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -D---------------------------------------------------------- ----------EDSQS--------------------------------------------- ---------------------------SYEDNST-------------------------- ---------------EIEAPVVPALAHSVR------------------------------ --------------------------------------AKD------------------- ------------------------------------------------------------ ----------------------ARPSTFRHRQA--------------------------- ------GSQPGN---SDSSPQPSH------------------------------------ ------------------------------------------------------------ ------------------------------------------------V----------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------RPSR---------------------------------- ------------------------------------------------------------ ----------------P------------------------------------------- -----------------------GS-------------------PYHRAQVS-------- -------------------------------------------------------SRAG- ---------VQATP--VKKISPSKGPLLP------------------------------- ----------ESQQSVFIEEE-------------EEE-EEEKEGIVK-GKE-DALTTSVS KWPSSSP-HRNNKYADR-NFEKDRAAT--------------------------------- -------------------GL------------APQGGSLVQEENTI------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------PG-------------------------------------- -------------------RR----P-P-------------------------------- ------------------------------------------------------------ ------------------------------G------------------SR--LVASHPP PQYQS-----------RNP----------------------------ATAS--------- ---------------------------------PASSTHSWPR----------------- --------------YTTRAPPSY------------------------------------- ----SST-T--------------------------------------------------- ------------------------------PML----------SLRQRMQR--------- ---------------RFRTPV-----SRQ-------------PP---------------- ------------------------------------------------------------ --------------------------SRPVL------A------Q--------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------GYNGRPNI----------- --EEH---IPPGGIGKPNGQRVINGPQGTKWVVDLDRGLVFNAEGRYLQDSHGNPLRVRL GGDGRTIVDLGGTPMVSPDGLPLFGQGRHGKPLASAQDKPILSLGGKPLVGLE--VIKTT THLP-TT-----TMPP---------TTTTSTVP-------TT--TTTLQPQTT---TT-- --RR---TTT-----TRRTTTTTT------------------------------------ ---RRTT-TTRR-------PTTTTR--------ATRR----------------TTT--TT ----------TTPEP-------------TT------------------------------ -PSPTCPPGTLEHQDEAGNLIM-GSNGIPECY--------------------------P- ------------------------EEDEFSGLETD--------TAAPMEEDYVVYDG--- ---------------------D--------YG-FE-ATR-------P-----P---T--- -------TIMPS-------------------------------------------TTA-- TTPK-----------VIPEQGT----------------------V--------------- -----SSFPEEEFDLAGKKRFI--------------------------APYVTYLSKDPS APCSLTDALDHFQVESLDELIPND--LTKNELPPQHAPRNITVVAMEGCHSFVIVDWNKA IPGDVVTGYLVYSASYEDFIRNKWSTQTSSVTHLPIENLKPNT----------------- -------------RYYFKVQAKNPHGYGPVSPSVSFVTESDNPLLVVRPPG--------- ------GEPIWIPFAFKHDPGYTDCHGRQYVKRTWYKKFVGVVLCNSLRYKIYLSDNL-K -DTFYSIGDSWGRGEDHCQFVDSHLDGRTGPQSYVEALPTIQGYHRQYRQEPVSFGNIGF GTPYYYVGWYECGVSIPGKW---------------------------------------- ------------------------------------------------------ >ENSCGRP00000024470 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------MGLKVTWDPPKDATSRPV----EHYN ------------------------------------------------------I-AYGK S-----------------------------------------------LK---------- -----------SLKYIKVNSETNSFLIEDV------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------EKEVPNKPVRLRVRAS-------------------------------------- -----------------DDRLSVAWKAPRL-SGAKS-------PR-RSRGFLLGYG---- -ESGRKMNY------------VPLTRDERSHEIKKL---ASESV---------------- ---------YVVSLQSTN-----------------SQGQSQPVYRAALTKRKNSED---- ---SELDLPEDISVRVMSSQSVLVAWVDPLVE-KQKRVV--TS-RQYTVRYREKGESARW DYKQVSNRRALVDGLLPDTVYEFAVRISQGERDGKWSASIFQRTPESAPTIAPENLNVWP VSGKPTAVTVSWDALPETEGKVKEYILSYAPALKPFGAKSLTFSGHTTSAMVDGLQPGER YLFKIRATNRRGPGPHSKAFIVTIPT-----------T-SSTEASAHQ--NGGNSWKPEQ SQ----------------------------------------------PSSPAPKAAT-- -------SSEHT------------------------------------------------ -----------PPAKNAKDVLLDLKNKILANGGPPRKTHLHS-KMGAL---DPQ------ EVTG-------EEELDSLEDPRPAQSE-------------TLD----------------- -----------QRRPLRI--PSRPGHRVLAPGRTPARAGLPVLPRKEGMDR-RGPSLVPY --------PR---------------------------------------SGAEPSVTA-S -------------S---------------------------------------------- -------------------------TH---------------------------P----- ------------------------------------------------------------ ----------------------------------ITDN---------------------- ----------------------DSVSQNEHDQE---------GSPD-------------- ------------------------------------------------------------ -----------------PK----------------------------------------- ---------------AASSQS-PNNP---------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------VGSKPTPT----------- ------PSRHVASNMLRDKSRMLPGAKA------ESSASRNSHSSTS------------- --------------------------------------EEDSSAAAQ------------- ------PSG---------------------------HFPLHRGSSR-----PHSRS---- -------QLSRGLKDRQDAPASGSH---------------TPSRTAVSPSGSSHPFSQTE GSEEEDT----------------------------------------------------- ------------------------------------------------------------ -------------------------------------------------------SDGWG DGDRDAGDTRRQAEATAQTQQT---------R---------------------------- ------------PALGHFSLTRNKPFATHSRNPNRFPRFRGLRLHPSVS---PQS---TS ASKVL------------------------------------------------------- --------------------TRAPSQPTS------------------------------- HTRPSPDVYRG--------------------------GEDEEPLP-------------AT ------------------------------------------------------------ ---------------------VVNDR-T------------P-----------------SS S------------------RHPASGGWDTLRRGPQRGASLYRKEPIPENP---------- -------------------------------KTA-------------------------- ----------------------------------------------------------GA --------------------------DVHPGGK--------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------SPLSSKAQDLQQS-THEDA----RRTS PGSTSRQLPPARL----------------------------------------------- ---------------------------------------------------PAS------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------RSQP----------------- ------------------------------------------------------------ ---------------------------------------------------FPG-STVPR RLAPSRSSEIS----------------------------------SSQSKDSDRSLSQPK LMPD-------------------------------------------------------- ---------------HTGRDR--------------------------------------- ------------------------------------------------------------ ---------------------------SHT-----------------------------L NS--------------------RGMLPSASQSQ--------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -D---------------------------------------------------------- ----------EDSQS--------------------------------------------- ---------------------------SYEDNST-------------------------- ---------------EIEAPVVPALAHSVR------------------------------ --------------------------------------AKD------------------- ------------------------------------------------------------ ----------------------ARPSTFRHRQA--------------------------- ------GSQPGN---SDSSPQPSH------------------------------------ ------------------------------------------------------------ ------------------------------------------------V----------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------RPSR---------------------------------- ------------------------------------------------------------ ----------------P------------------------------------------- -----------------------GS-------------------PYHRAQVS-------- -------------------------------------------------------SRAG- ---------VQATP--VKKISPSKGPLLP------------------------------- ----------ESQQSVFIEEE-------------EEE-EEEKEGIVK-GKE-DALTTSVS KWPSSSP-HRNNKYADR-NFEKDRAAT--------------------------------- -------------------G-------------------LVQEENTI------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------PG-------------------------------------- -------------------RR----P-P-------------------------------- ------------------------------------------------------------ ------------------------------G------------------SR--LVASHPP PQYQS-----------RNP----------------------------ATAS--------- ---------------------------------PASSTHSWPR----------------- --------------YTTRAPPSY------------------------------------- ----SST-T--------------------------------------------------- ------------------------------PML----------SLRQRMQR--------- ---------------RFRTPV-----SRQ-------------PP---------------- ------------------------------------------------------------ --------------------------SRPVL------A------Q--------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------GYNGRPNI----------- --EEH---IPPGGIGKPNGQRVINGPQGTKWVVDLDRGLVFNAEGRYLQDSHGNPLRVRL GGDGRTIVDLGGTPMVSPDGLPLFGQGRHGKPLASAQDKPILSLGGKPLVGLE--VIKTT THLP-TT-----TMPP---------TTTTSTVP-------TT--TTTLQPQTT---TT-- --RR---TTT-----TRRTTTTTT------------------------------------ ---RRTT-TTRR-------PTTTTR--------ATRR----------------TTT--TT ----------TTPEP-------------TT------------------------------ -PSPTCPPGTLEHQDEAGNLIM-GSNGIPECY--------------------------P- ------------------------EEDEFSGLETD--------TAAPMEEDYVVYDD--- ---------------------D--------YG-FE-ATR-------P-----P---T--- -------TIMPS-------------------------------------------TTA-- TTPK-----------VIPEQGT----------------------V--------------- -----SSFPEEEFDLAGKKRFI--------------------------APYVTYLSKDPS APCSLTDALDHFQVESLDELIPND--LTKNELPPQHAPRNITVVAMEGCHSFVIVDWNKA IPGDVVTGYLVYSASYEDFIRNKWSTQTSSVTHLPIENLKPNT----------------- -------------RYYFKVQAKNPHGYGPVSPSVSFVTESDNPLLVVRPPG--------- ------GEPIWIPFAFKHDPGYTDCHGRQYVKRTWYKKFVGVVLCNSLRYKIYLSDNL-K -DTFYSIGDSWGRGEDHCQFVDSHLDGRTGPQSYVEALPTIQGYHRQYRQEPVSFGNIGF GTPYYYVGWYECGVSIPGKW---------------------------------------- ------------------------------------------------------ >ENSCGRP00001003549 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------MGLKVTWDPPKDATSRPV----EHYN ------------------------------------------------------I-AYGK S-----------------------------------------------LK---------- -----------SLKYIKVNSETNSFLIEDV------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------EKEVPNKPVRLRVRAS-------------------------------------- -----------------DDRLSVAWKAPRL-SGAKS-------PR-RSRGFLLGYG---- -ESGRKMNY------------VPLTRDERSHEIKKL---ASESV---------------- ---------YVVSLQSTN-----------------SQGQSQPVYRAALTKRKNSED---- ---SELDLPEDISVRVMSSQSVLVAWVDPLVE-KQKRVV--TS-RQYTVRYREKGESARW DYKQVSNRRALVDGLLPDTVYEFAVRISQGERDGKWSASIFQRTPESAPTIAPENLNVWP VSGKPTAVTVSWDALPETEGKVKEYILSYAPALKPFGAKSLTFSGHTTSAMVDGLQPGER YLFKIRATNRRGPGPHSKAFIVTIPT-----------T-SSTEASAHQ--NGGNSWKPEQ SQ----------------------------------------------PSSPAPKAAT-- -------SSEHT------------------------------------------------ -----------PPAKNAKDVLLDLKNKILANGGPPRKTHLHS-KMGAL---DPQ------ EVTG-------EEELDSLEDPRPAQSE-------------TLD----------------- -----------QRRPLRI--PSRPGHRVLAPGRTPARAGLPVLPRKEGMDR-RGPSLVPY --------PR---------------------------------------SGAEPSVTA-S -------------S---------------------------------------------- -------------------------TH---------------------------P----- ------------------------------------------------------------ ----------------------------------ITDN---------------------- ----------------------DSVSQNEHDQE---------GSPD-------------- ------------------------------------------------------------ -----------------PK----------------------------------------- ---------------AASSQS-PNNP---------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------VGSKPTPT----------- ------PSRHVASNMLRDKSRMLPGAKA------ESSASRNSHSSTS------------- --------------------------------------EEDSSAAAQ------------- ------PSG---------------------------HFPLHRGSSR-----PHSRS---- -------QLSRGLKDRQDAPASGSH---------------TPSRTAVSPSGSSHPFSQTE GSEEEDT----------------------------------------------------- ------------------------------------------------------------ -------------------------------------------------------SDGWG DGDRDAGDTRRQAEATAQTQQT---------R---------------------------- ------------PALGHFSLTRNKPFATHSRNPNRFPRFRGLRLHPSVS---PQS---TS ASKVL------------------------------------------------------- --------------------TRAPSQPTS------------------------------- HTRPSPDVYRG--------------------------GEDEEPLP-------------AT ------------------------------------------------------------ ---------------------VVNDR-T------------P-----------------SS S------------------RHPASGGWDTLRRGPQRGASLYRKEPIPENP---------- -------------------------------KTA-------------------------- ----------------------------------------------------------GA --------------------------DVHPGGK--------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------SPLSSKAQDLQQS-THEDA----RRTS PGSTSRQLPPARL----------------------------------------------- ---------------------------------------------------PAS------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------RSQP----------------- ------------------------------------------------------------ ---------------------------------------------------FPG-STVPR RLAPSRSSEIS----------------------------------SSQSKDSDRSLSQPK LMPD-------------------------------------------------------- ---------------HTGRDR--------------------------------------- ------------------------------------------------------------ ---------------------------SHT-----------------------------L NS--------------------RGMLPSASQSQ--------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -D---------------------------------------------------------- ----------EDSQS--------------------------------------------- ---------------------------SYEDNST-------------------------- ---------------EIEAPVVPALAHSVR------------------------------ --------------------------------------AKD------------------- ------------------------------------------------------------ ----------------------ARPSTFRHRQA--------------------------- ------GSQPGN---SDSSPQPSH------------------------------------ ------------------------------------------------------------ ------------------------------------------------V----------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------RPSR---------------------------------- ------------------------------------------------------------ ----------------P------------------------------------------- -----------------------GS-------------------PYHRAQVS-------- -------------------------------------------------------SRAG- ---------VQATP--VKKISPSKGPLLP------------------------------- ----------ESQQSVFIEEE-------------EEE-EEEKEGIVK-GKE-DALTTSVS KWPSSSP-HRNNKYADR-NFEKDRAAT--------------------------------- -------------------G-------------------LVQEENTI------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------PG-------------------------------------- -------------------RR----P-P-------------------------------- ------------------------------------------------------------ ------------------------------G------------------SR--LVASHPP PQYQS-----------RNP----------------------------ATAS--------- ---------------------------------PASSTHSWPR----------------- --------------YTTRAPPSY------------------------------------- ----SST-T--------------------------------------------------- ------------------------------PML----------SLRQRMQR--------- ---------------RFRTPV-----SRQ-------------PP---------------- ------------------------------------------------------------ --------------------------SRPVL------A------Q--------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------GYNGRPNI----------- --EEH---IPPGGIGKPNGQRVINGPQGTKWVVDLDRGLVFNAEGRYLQDSHGNPLRVRL GGDGRTIVDLGGTPMVSPDGLPLFGQGRHGKPLASAQDKPILSLGGKPLVGLE--VIKTT THLP-TT-----TMPP---------TTTTSTVP-------TT--TTTLQPQTT---TT-- --RR---TTT-----TRRTTTTTT------------------------------------ ---RRTT-TTRR-------PTTTTR--------ATRR----------------TTT--TT ----------TTPEP-------------TT------------------------------ -PSPTCPPGTLEHQDEAGNLIM-GSNGIPECY--------------------------P- ------------------------EEDEFSGLETD--------TAAPMEEDYVVYDD--- ---------------------D--------YG-FE-ATR-------P-----P---T--- -------TIMPS-------------------------------------------TTA-- TTPK-----------VIPEQGT----------------------V--------------- -----SSFPEEEFDLAGKKRFI--------------------------APYVTYLSKDPS APCSLTDALDHFQVESLDELIPND--LTKNELPPQHAPRNITVVAMEGCHSFVIVDWNKA IPGDVVTGYLVYSASYEDFIRNKWSTQTSSVTHLPIENLKPNT----------------- -------------RYYFKVQAKNPHGYGPVSPSVSFVTESDNPLLVVRPPG--------- ------GEPIWIPFAFKHDPGYTDCHGRQYVKRTWYKKFVGVVLCNSLRYKIYLSDNL-K -DTFYSIGDSWGRGEDHCQFVDSHLDGRTGPQSYVEALPTIQGYHRQYRQEPVSFGNIGF GTPYYYVGWYECGVSIPGKW---------------------------------------- ------------------------------------------------------ >ENSMAUP00000002800 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------------MA-------- ---PVAGA---SPRP-LPWAA-LLLLAALLPVASSAG-PP-------------------- ------------------------------------------------VDHPL------- -----------------------KPRHVKLLSTKMGLKVTWDPPKDATSRPV----EHYN ------------------------------------------------------I-AYGK S-----------------------------------------------LK---------- -----------SLKYIKVNAETNSFLIEDV------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------EKEVPNKPVRLRVRAS-------------------------------------- -----------------DDRLSVAWKAPRL-SGAKS-------PR-RSRGFLLGYG---- -ESGRKMNY------------VPLTRDERSHEIKKL---ASESV---------------- ---------YVVSLQSTN-----------------SQGQSQPVYRAALTKRKNSED---- ---SELDLPEDISVRVISSQSVLVAWVDPLVE-KQKRVA--AS-RQYTVRYREKGESARW DYKQVSNRRALVDSLLPDTVYEFAVRISQGERDGKWSASIFQRTPESAPTIAPENLKVWP VSGKPTAVTVSWDALPETEGRVKEYILSYAPALKPFGAKSLTFSGHTTSAMVDGLQPGER YLFKIRATNRRGQGPHSKAFIVTVPT-----------T-GSTEAKAHQ--DGGNSWKPER PQ----------------------------------------------PSSLAPKATT-- -------SSEHT------------------------------------------------ -----------SPAKNAKDVLLDLKNKILANGGPPRKPQLHS-KMGAL---DPQ------ EVTG-------EEELDSLEDPRPPRSE-------------TLD----------------- -----------QRRPLRI--PSRSGHWVPAPGRTPARAGLPVLPRKEGMDR-RGPSMAPH --------PR---------------------------------------PGAEPSVTA-S -------------S---------------------------------------------- -------------------------TP---------------------------P----- ------------------------------------------------------------ ----------------------------------ITDN---------------------- ----------------------DSVNQNEDDQG---------GSPD-------------- ------------------------------------------------------------ -----------------AT----------------------------------------- ---------------AASSQS-PNNP---------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------VGSKPTPT----------- ------PSRHVASNMLRDKSRLLPGAKA------ESSASRNSHSSTS------------- --------------------------------------EEDSSAAAP------------- ------PSG---------------------------HFPLHRG------------S---- -------QLSRGWKDRQGVPASGSH---------------MLSRTTVSPTVSSHPLSLTG GLEEEGT----------------------------------------------------- ------------------------------------------------------------ -------------------------------------------------------SDGGG VGDRDAGDTRRQAEATAHTQQT---------R---------------------------- ------------PALGHFSLTRNKPFATHSRTPNRSPRVRGLRPQPSVS---PQA---TS ASKVL------------------------------------------------------- --------------------SRTPSQTAS------------------------------- HARPGSDVYGD--------------------------GEDEEPLP-------------AT ------------------------------------------------------------ ---------------------VVTDP-T------------P-----------------SS S------------------RHPASGGWDTLRRGPQRGASLYRKEPIPENP---------- -------------------------------KTA-------------------------- ----------------------------------------------------------GA --------------------------DVHPGRK--------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------SPVSSKTQDLQQS-THEDA----HRTS PGSSSRQLSPARL----------------------------------------------- ---------------------------------------------------PAS------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------RSQA----------------- ------------------------------------------------------------ ---------------------------------------------------FPG-STVPR RLAPGRSSEVS----------------------------------SSQSTDNDRSLSQPK LLLD-------------------------------------------------------- ---------------RTGHGR--------------------------------------- ------------------------------------------------------------ ---------------------------SHT-----------------------------L NS--------------------RGMLPSASQSQ--------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -D---------------------------------------------------------- ----------EDSQS--------------------------------------------- ---------------------------SYEDNSS-------------------------- ---------------EMEAPDSRALTHSAR------------------------------ --------------------------------------AKD------------------- ------------------------------------------------------------ ----------------------ATLSAFRFRQA--------------------------- ------GSQLGN---GDNNPQPSH------------------------------------ ------------------------------------------------------------ ------------------------------------------------V----------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------RPRG---------------------------------- ------------------------------------------------------------ ----------------P------------------------------------------- -----------------------GS-------------------PYHQAQVS-------- -------------------------------------------------------SRAG- ---------VQTTP--VKKISPSKLP--P------------------------------- ----------ESQQSVF-TEE-------------DEE-EEEKEGIVK-GKE-DSLTTSIS KWPPSSP-HRNNKYADR-NFDKDRAAA--------------------------------- -------------------G-------------------LVQEENT-------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------G-------------------------------------- -------------------RR----L-P-------------------------------- ------------------------------------------------------------ ------------------------------G------------------SP--PVASHPP LRYQP-----------RTP----------------------------ATAS--------- ---------------------------------PTTGTHSWPR----------------- --------------YTTRAPPSY------------------------------------- ----SST-T--------------------------------------------------- ------------------------------PML----------SLRQRMQR--------- ---------------RFRTPV-----SRQ-------------PP---------------- ------------------------------------------------------------ --------------------------SRPVL------A------Q--------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------GYNGRPNV----------- --EEN---IPPGSIGKPNGQRIINGPQGTKWVVDLDRGLVFNAEGRYLQDSHGNPLRVRL GGDGRTIVDLGGTPMVSPDGLPLFGQGRHGKPLASAQDKPILSLGGKPLVGLE--VIKTT T-----------------------------TVP-------TT--TTTLQPQTT---TTTL QPQT---TTT-----TRRTTTTTT------------------------------------ ---RRTT-TTRR-------PTTTIR--------ATRR----------------TTT--TT ----------TTPEP-------------TT------------------------------ -PSPTCPPGTLEHQDEAGNLIM-GSNGIPECY--------------------------P- ------------------------EEDDFSGLEAD--------TAAPIEEDYAVYDD--- ---------------------D--------YG-LE-VTR-------P-----P---T--- -------TVIPS-------------------------------------------TTA-- ATPK-----------VIPEQGT----------------------V--------------- -----SSFPEEEFDLAGKKRFI--------------------------APYVTYLSKDPS APCSLTDALDHFQVESLDELIPND--LTKNDLPPQHAPRNITVVAMEGCHSFVIVDWNKA IPGDVVTGYLVYSASYEDFIRNKWSTQTSSVTHLPIENLKPNT----------------- -------------RYYFKVQAKNPHGYGPVSPSVSFVTESDNPLLVVRPPG--------- ------GEPIWIPFAFKHDPGYTDCHGRQYVKRTWYKKFVGVVLCNSLRYKIYLSDNL-K -DTFYSIGDSWGRGEDHCQFVDSHLDGRTGPQSYVEALPTIQGYYRQYRQEPVSFGNIGF GTPYYYVGWYECGVSIPGKW---------------------------------------- ------------------------------------------------------ >ENSPEMP00000017022 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------MGLKVTWDPPKDATSRPV----EYYN ------------------------------------------------------I-AYGK A-----------------------------------------------LK---------- -----------SLKYIKVNAETNSFLIEDV------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------EREVPNKPVRMRVRAS-------------------------------------- -----------------DDRLSVAWKAPRL-SGAKS-------PR-RSRGFLLGYG---- -ESGRKMNY------------VPLTRDERSHEIKKL---ASESV---------------- ---------YVVSLQSTN-----------------SQGPSQPVYRAALTKRKNSED---- ---SELDVPEDISVRVMSSQSVLVAWVDPLVE-KQKRVV--AS-RQYTVRYREKGESARW DYKQVSNRRVLVDNLIPDTVYEFAVRISQGERDGKWSASIFQRTPESAPTTAPENLNVWP VSGKSTVVTVSWDALPETEGKVKEYILSYAPALKPFGAKSLTFSGHTTSALVDGLQPGER YLFKIRATNRRGQGPHSKAFIVTMPT-----------T-SSTEASPRQ--DGRN-----K PQ----------------------------------------------PSSPAPKTAA-- -------SSEPT------------------------------------------------ -----------PPAKNVKDVLLDLKNKILANGGLPRKSQLRS-KQGEL---DPQA----T EVTG-------EEELDSLEDPRSLRLE-------------TLD----------------- -----------QRRPLRV--PSRSGPWVPASGRTPSRAGPPVPPRKEGMDR-RGPSLVPH --------PR---------------------------------------PGVEPSVTA-S -------------SA--------------------------------------------- -------------------YSRLSS----------------------------------- ------------------------------------------------------------ -----------------------------------TDN---------------------- ----------------------DSLNQNEDDQ-------------DV------------- --------S--------------------------------------------------- ---------------LAPK----------------------------------------- ---------------AASSQS-PKDP---------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------VRSQSTST----------- ------PSRHVASHMLRDKSRVLPGAKA------ESSASTHSHSSTS------------- --------------------------------------EEDSSAAAQ------------- ------PSG---------------------------LFPLQRGLSR-----PHSRF---- -------QLSRGWKNRQDAPASSSH---------------TPSQTAVSPSGSSHPLALTE GSEEENT----------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ----DAGDTRRQAEATAQTQQT---------R---------------------------- ------------PALAPFSLTRNKPFTAHGRNPNRFSRFRGLRLQPSGS---PQS---TS APKVL------------------------------------------------------- --------------------TRASSQPAS------------------------------- HTRPGSDVYGD--------------------------GEDEEPLS-------------TT ------------------------------------------------------------ ---------------------VVNDR-T------------PS----------------SS S------------------RHPASGGWDTLRRGSQRGASLYRKDPTPENP---------- -------------------------------KAA-------------------------- ----------------------------------------------------------GA --------------------------DVYPEGK--------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------SPLSSTVQDFQQS-TNEDA----HQIS PGSTTRQLPPARL----------------------------------------------- ---------------------------------------------------PAS------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------RSQP----------------- ------------------------------------------------------------ ---------------------------------------------------FPG-STVPR RMVPGRSSEVS----------------------------------SSQSKDDDRSLSQPK LLRD-----------------------------------------------------RLR TANSGRMLPAVPQSRH-------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------EDSQS--------------------------------------------- ---------------------------SYEDNST-------------------------- ---------------EVEDPDPRAPTHSAR------------------------------ --------------------------------------AKD------------------- ------------------------------------------------------------ ----------------------ADPSTLRHRQG--------------------------- ------SSQPGN---GDSSPQPSH------------------------------------ ------------------------------------------------------------ ------------------------------------------------TGAS-------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------GRPSR---------------------------------- ------------------------------------------------------------ ----------------P------------------------------------------- -----------------------GS-------------------SHPRTQVS-------- -------------------------------------------------------SRAG- ---------VQATP--VKKISPSKGPLPP------------------------------- ----------ESQQSVF--AE-------------EEE-EEENEGVLK-GKE-DSLSTSVS KWPSSSS-RRGDKYGDR-NFDKDKAAI--------------------------------- -------------------G------------------NLVQEENTI------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------PG-------------------------------------- -------------------RR----P-P-------------------------------- ------------------------------------------------------------ ------------------------------G------------------SP--SIVSHPS PRYQP-----------RNP----------------------------ATAS--------- ---------------------------------STASTHSWPR----------------- --------------YTTRAPPSY------------------------------------- ----AST-T--------------------------------------------------- ------------------------------PML----------SLRQRMQR--------- ---------------RFRTPV-----SRQ-------------PP---------------- ------------------------------------------------------------ ---------------------------RPVL------T------Q--------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------GYNGRPNV----------- --EEN---IPPGSIGKPNGQRIINGPQGTKWVVDLDRGLVFNAEGRYLQDSHGNPLRVRL GGDGRTIVDLGGTPMVSPDGLPLFGQGRHGKPLASAQDKPILSLGGKPLVGLE--VIKTT THPP-TT-----TMPP---------TTTMTTTV-------PT--TTTLQP---------- --------TT-----TRRTTTTTT------------------------------------ ---RRTT-TTTRRTTTTRCPTTTVR--------ATRR----------------TTT--TT ----------TTPEP-------------TT------------------------------ -PSPTCPPGTLEQQDEAGNLIM-GSNGIPECY--------------------------P- ------------------------EEDDFSGLETD--------TAPPTEEDYVVYDD--- ---------------------D--------YG-LE-TTR-------P-----L---T--- -------TIMPS-------------------------------------------TTA-- ATMK-----------VIPEQGT----------------------V--------------- -----SSFPEEEFDLAGKKRFV--------------------------APYVTYLSKDPS APCSLTDALDHFQVESLDELIPND--LTKSDLPPQHAPRNITVVAMEGCHSFVIVDWNKA IPGDVVTGYLVYSASYEDFIRNKWSTQTSSVTHLPIENLKPNT----------------- -------------RYYFKVQAKNPHGYGPVSPSVSFVTESDNPLLVVRPPG--------- ------GEPIWIPFAFKHDPGYTDCHGRQYVKRTWYKKFVGVVLCNSLRYKIYLSDNL-K -DTFYSIGDSWGRGEDHCQFVDSHLDGRTGPQSYVEALPTIQGYHRQYRQEPVSFGNIGF GTPYYYVGWYECGVSIPGKW---------------------------------------- ------------------------------------------------------ >ENSMUSP00000095036 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------MGLKVTWDPPKDASSRPV----EYYN ------------------------------------------------------I-AYGK S-----------------------------------------------LK---------- -----------SLKSIKVNAETHSFLIKDV------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------EKEVPNKPLRMRVRAS-------------------------------------- -----------------DDRLSVAWKAPRL-SGAKS-------PR-RSRGFLLGYG---- -ESGRKMNY------------VPLTRDERSHEIKKL---ASESV---------------- ---------YVVSLQSTN-----------------SQGQSQPVYRAALTKRKHAEE---- ---DELDVPEDISVRVMSSQSVLVAWVDPLVE-KQKRVV--AS-RQYTVRYREKGESARW DYKQVSNRRVLVDSLIPDTVYEFAVRISQGERDGKWSASIFQRTPESAPTTAPENLRVWP VSGKPTVVTVSWDALPESEGKVKEYILSYAPALKPFGAKSLTFSGHTTSALVDGLQPGER YLFKIRATNRRGPGPHSKAFIVAIPT-----------T-SSTEASAQP--NGRDS----- ---------------------------------------SRKPEKLQQPSSPAPKVAA-- -------SSEHT------------------------------------------------ -----------PSAKNVKDALSDL-NKIRTNSVVPGKTQLHS-KMGEL---DPQS----T EVTG-------EEELDSLEDPRSSRLE-------------TLN----------------- -----------QKQPLRV--PSRSGHGVLTPGRTPARTGLPVLPRKEVMDR-RGPSLDPH --------LR---------------------------------------PRVEPSA---S -------------SA--------------------------------------------- -------------------YHQLSS----------------------------------- ------------------------------------------------------------ -----------------------------------IDN---------------------- ----------------------DSVDQNEYDQA---------GSPD-------------- ------------------------------------------------------------ -----------------PK----------------------------------------- ---------------AVSSPSSPKNP---------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------ARSRLTSV----------- ------PSRHAASNMLRDKSRMQPGTKA-----SSSSASSQSHSSTS------------- --------------------------------------EEDSSAAAQ------------- ------PRS---------------------------HSLLQGGS---------SRP---- -------ALSR---DRQDVHASSSR---------------MPSQTV----SSSRPSALTE GSEEEDT----------------------------------------------------- ------------------------------------------------------------ -------------------------------------------------------SDGGA DIDRAAGDTRRRAEATAQIQQT---------R---------------------------- ------------PALGHFSLIRNKPFPAHSRNPSRFPKLRGPRLQPSRS---PQS---TS ASKVL------------------------------------------------------- --------------------TRAPSLPAS------------------------------- HTRPGSDVYGD--------------------------GEDEEPLP-------------AT ------------------------------------------------------------ ---------------------VVNDR-T------------P-----------------SS S------------------SHPISGGSDTLRRGSQRGASLYRKEPIPENS---------- -------------------------------KAA-------------------------- ----------------------------------------------------------GA --------------------------DVHPGGK--------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------SPLSSKAQGFQLS-TDEGA----PQTP PSSTSRQLSPARH----------------------------------------------- ---------------------------------------------------PAS------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------RSQP----------------- ------------------------------------------------------------ ---------------------------------------------------SPG-STVPR RMAPGRSSELS----------------------------------SSQS--KDRSLSQPK LSLA-------------------------------------------------------- ---------------HTGPDR--------------------------------------- ------------------------------------------------------------ ---------------------------PHA-----------------------------A NS--------------------RGVLPSAPQNQNEG------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------SQS--------------------------------------------- ---------------------------SYEDNST-------------------------- ---------------EIEGPDPRAPTHSAH------------------------------ --------------------------------------AKD------------------- ------------------------------------------------------------ ----------------------TTPSILKPQQM--------------------------- ------GSQSGN---SGNRPQPSR------------------------------------ ------------------------------------------------------------ ------------------------------------------------SGAS-------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------ERPIR---------------------------------- ------------------------------------------------------------ ----------------P------------------------------------------- -----------------------GS-------------------THPRVQVP-------- -------------------------------------------------------GRAG- ---------LQATP--AKKISSSKHPLPP------------------------------- ----------ESQQSVFT-----------------EE-EEENEGILK-GKE-DSLSTSVK KWPSSSS-PRNNKYADR-NLDRDKAAI--------------------------------- -------------------G------------------QLVQEEDSI------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------PG-------------------------------------- -------------------RR----S-P-------------------------------- ------------------------------------------------------------ ------------------------------G------------------SP--PIASHPP TWYQP-----------RNP----------------------------VTAS--------- ---------------------------------PSASTHSWPR----------------- --------------YTTRAPSTY------------------------------------- ----SST-T--------------------------------------------------- ------------------------------PML----------SLRQRMQR--------- ---------------RFRTPV-----SRQ-P-----------PP---------------- ------------------------------------------------------------ ---------------------------RPVL------T------S--------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------GYNGRANV----------- --GEN---IPPGSIGKPNGQRIINGPQGTKWVVDLDRGLVLNAEGRYLQDSHGNPLRVRL GGDGRTIVDLGGTPMVSPDGLPLFGQGRHGKPVASAQDKPILSLGGKPLVGLE--VIKTT TYSP-TT-----TMLP---------TTTTTTVL--------T--TTTRPPTTT---T--- --------TT-----TRR---TTT------------------------------------ ---RRTT-TTRH-------PTTTIR--------ATRR----------------TTT--TT ----------TTPEP-------------TT------------------------------ -PSPTCPPGTLEHQDEAGNLIM-GSNGIPECY--------------------------P- ------------------------EEDDFSGLETD--------TAPPTEEDYVVYDD--- ---------------------D--------YG-FE-TTR-------P-----P---T--- -------STMPS-------------------------------------------TTA-- ATPK-----------VIPEQGT----------------------V--------------- -----SSFPEEEFDLAGKRRFV--------------------------APYVTYLSKDPT APCSLTDALDHFQVESLDELIPND--LTKSDLPPQHAPRNITVVAMEGCHSFVIVDWNKA IPGDVVTGYLVYSASYEDFIRNKWSTQTSSVTHLPIENLKPNT----------------- -------------RYYFKVQAKNPHGYGPVSPSVSFVTESDNPLLVVRPPG--------- ------GEPIWIPFAFKHDPGYTDCHGRQYVKRTWYKKFVGVVLCNSLRYKIYLSDNL-K -DTFYSIGDSWGRGEDHCQFVDSHLDGRTGPQSYIEALPNIQGYYRQYRQEPVSFGHIGF GTPYYYVGWYECGVSIPGKW---------------------------------------- ------------------------------------------------------ >MGP_SPRETEiJ_P0044523 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------MGLKVTWDPPKDASSRPV----EYYN ------------------------------------------------------I-AYGK S-----------------------------------------------LK---------- -----------SLKSIKVNAETHSFLIKDV------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------EKEVPNKPLRMRVRAS-------------------------------------- -----------------DDRLSVAWKAPRL-SGAKS-------PR-RSRGFLLGYG---- -ESGRKMNY------------VPLTRDERSHEIKKL---ASESV---------------- ---------YVVSLQSTN-----------------SQGQSQPVYRAALTKRKHAEE---- ---DELDVPEDISVRVMSSQSVLVAWVDPLVE-KQKRVV--AS-RQYTVRYREKGESARW DYKQVSNRRVLVDSLIPDTVYEFAVRISQGERDGKWSASIFQRTPESAPTTAPENLRVWP VSGKPTVVTVSWDALPESEGKVKEYILSYAPALKPFGAKSLTFSGHTTSALVDGLQPGER YLFKIRATNRRGPGPHSKAFIVAIPT-----------T-SSTEASAQP--NGRDS----- ---------------------------------------SRKPEKLQQPSSPAPKVAV-- -------SLEHT------------------------------------------------ -----------PSAKNVKDALSDLKNKIRTNGVVPGKTQLHS-KMGEL---DPQS----T EVTG-------EEELDSLEDPRSSRLE-------------TLN----------------- -----------QKQPLRV--PSRSGHGVLAPGRTPARTGLPVLPRKEVMDR-RGPSLDPH --------LR---------------------------------------PRVEPSA---S -------------SA--------------------------------------------- -------------------YHQLSS----------------------------------- ------------------------------------------------------------ -----------------------------------IDN---------------------- ----------------------DSVDQNEYDQA---------GSPD-------------- ------------------------------------------------------------ -----------------PK----------------------------------------- ---------------AVSSLSSPKNP---------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------ARSRPTSV----------- ------PSRHAASNMLRDKSRMHPGTKA-----SSSSASSQSHSSTS------------- --------------------------------------EEDSSAAAQ------------- ------PRSR-------------------------SHSLLQGGS---------SRP---- -------ALSR---DRQDAHASSSR---------------MPSQTV----SSSRPSALTE GSEEEDT----------------------------------------------------- ------------------------------------------------------------ -------------------------------------------------------SDGGA DSDRAAGDTRRRAEATAQIQQT---------R---------------------------- ------------PALGHFSLIRNKPFPAHSRNPNRFPKLRGPRLQPSRS---PQS---TS ASKVL------------------------------------------------------- --------------------TRAPSLPAS------------------------------- HTRPGSDVYGD--------------------------GEDEEPLP-------------AT ------------------------------------------------------------ ---------------------VVNDR-T------------P-----------------SS S------------------SHLISGGSDTLRRGSQRGASLYRKEPIPENS---------- -------------------------------KAA-------------------------- ----------------------------------------------------------GA --------------------------DVHPGGE--------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------FPLSSKAQGFQLS-TDEGA----PQTP PSSTSRQLSPARH----------------------------------------------- ---------------------------------------------------PAS------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------RSQP----------------- ------------------------------------------------------------ ---------------------------------------------------SPG-STVPR RMAPGRSSELS----------------------------------SSQS--KDRSLSQPK LSLA-------------------------------------------------------- ---------------HTGPDR--------------------------------------- ------------------------------------------------------------ ---------------------------PPA-----------------------------A NS--------------------RGVLPSAPQNQNEG------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------SQS--------------------------------------------- ---------------------------SYEDNST-------------------------- ---------------EIEGPDPRAPTHSAH------------------------------ --------------------------------------AKD------------------- ------------------------------------------------------------ ----------------------TTPSILKPQQM--------------------------- ------GSQSGN---SGNRPQPSR------------------------------------ ------------------------------------------------------------ ------------------------------------------------SGAS-------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------ERPIR---------------------------------- ------------------------------------------------------------ ----------------P------------------------------------------- -----------------------GS-------------------THPRVQVP-------- -------------------------------------------------------GRAG- ---------LQATP--AKKISSSKHPLPP------------------------------- ----------ESQQSVFA-----------------EE-EEENEGILK-GKE-DSLSTSVK KWPSSSS-PRNNKYADR-NLDRDKAAI--------------------------------- -------------------G------------------QLVQEEDSI------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------PG-------------------------------------- -------------------RR----S-P-------------------------------- ------------------------------------------------------------ ------------------------------G------------------SP--PVASHPP TWYQP-----------RTP----------------------------ATAS--------- ---------------------------------PSASTHSWPR----------------- --------------YTTRAPSTD------------------------------------- ----SST-T--------------------------------------------------- ------------------------------PML----------SLRQRMQR--------- ---------------RFRTPI-----SRQ-P-----------PP---------------- ------------------------------------------------------------ ---------------------------RPVL------T------S--------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------GYNGRANV----------- --GEN---IPPGSIGKPNGQRIINGPQGTKWVVDLDRGLVLNAEGRYLQDSHGNPLRVRL GGDGRTIVDLGGTPMVSPDGLPLFGQGRHGKPVASAQDKPILSLGGKPLVGLE--VIKTT TYSP-TT-----TMLP----------TTTTTVL--------T--TTTRPPTTT---T--- --------TT-----TRR---TTT------------------------------------ ---RRTT-TTRH-------PTTTIR--------ATRR----------------TTT--TT ----------TTPEP-------------TT------------------------------ -PSPTCPPGTLEHQDEAGNLIM-GSNGIPECY--------------------------P- ------------------------EEDDFSGLETD--------TAPPTEEDYVVYDD--- ---------------------D--------YG-FE-TTR-------P-----P---T--- -------STMPS-------------------------------------------TTA-- ATPK-----------VIPEQGT----------------------V--------------- -----SSFPEEEFDLAGKRRFV--------------------------APYVTYLSKDPT APCSLTDALDHFQVESLDELIPND--LTKSDLPPQHAPRNITVVAMEGCHSFVIVDWNKA IPGDVVTGYLVYSASYEDFIRNKWSTQTSSVTHLPIENLKPNT----------------- -------------RYYFKVQAKNPHGYGPVSPSVSFVTESDNPLLVVRPPG--------- ------GEPIWIPFAFKHDPGYTDCHGRQYVKRTWYKKFVGVVLCNSLRYKIYLSDNL-K -DTFYSIGDSWGRGEDHCQFVDSHLDGRTGPQSYIEALPNIQGYYRQYRQEPVSFGHIGF GTPYYYVGWYECGVSIPGKW---------------------------------------- ------------------------------------------------------ >MGP_CAROLIEiJ_P0042632 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------MGLKVTWDPPKDASSRPV----EYYN ------------------------------------------------------I-AYGK S-----------------------------------------------LK---------- -----------NLKSIKVNAETHSFLIKDV------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------EKEVPNKPLRMRVRAS-------------------------------------- -----------------DDRLSVAWKAPRL-SGAKS-------PR-RSRGFLLGYG---- -ESGRKMNY------------VPLTRDERSHEIKKL---ASESV---------------- ---------YVVSLQSTN-----------------SQGQSQPVYRAALTKRKHAEE---- ---DELDVPEDISVRVMSSQSVLVAWVDPLVE-KQKRVV--AS-RQYTVRYREKGESARW DYKQVSNRRVLVDSLIPDTVYEFAVRISQGERDGKWSASIFQRTPESAPTTAPENLRVWP VSGKPTVVTVSWDTLPESEGKVKEYILSYAPALKPFGAKSLTFSGHTTSALVDGLQPGER YLFKIRATNRRGPGPHSKAFIVAIPT-----------T-SSTEASAQP--DGRDS----- ---------------------------------------SRKPEKLQQPSSPAPKVAA-- -------SSKHT------------------------------------------------ -----------PSAKNVKDALSDL-NKIRTNGVVPGKTQLHS-KMGEL---DPQS----T EVTG-------EEELDSLEDPRSSRLE-------------TLN----------------- -----------QKQPLRV--PSRSGHGVLAPGRTPARTGLPVLPRKEVMDR-RGPSLDPH --------LR---------------------------------------PRVEPSA---S -------------SA--------------------------------------------- -------------------YHQLSS----------------------------------- ------------------------------------------------------------ -----------------------------------IDN---------------------- ----------------------DSVDQNEYDQA---------VSPD-------------- ------------------------------------------------------------ -----------------PK----------------------------------------- ---------------AASSLSSPKNP---------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------ARSRPTSV----------- ------PSRHAASNMLRDKSRMHPGTKA-----SSLSASSQSHSSTS------------- --------------------------------------EEDSSAAAQ------------- ------PRR---------------------------HFLRQGGS---------SRP---- -------ALSR---DRQDAHASGSS---------------TPSQTV----SSSHPSALTE GSEEEDT----------------------------------------------------- ------------------------------------------------------------ -------------------------------------------------------SDGGA DIDRAAGDTRRRAEATAQIQQT---------R---------------------------- ------------PALGHFSLIRNKPFPAHSRNPNRFPKLRGPRLQPSRS---PQS---TS ASKVL------------------------------------------------------- --------------------TRAPSLPAS------------------------------- HTRPGSDVYGD--------------------------GEDEEPLP-------------AT ------------------------------------------------------------ ---------------------VVNDR-T------------P-----------------SS S------------------SHPISGGSDTLRRGSQRGASLYGKEPIPENS---------- -------------------------------KAA-------------------------- ----------------------------------------------------------GA --------------------------DVHPGGK--------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------SPLSSKAQGFQLS-TDEGA----PQTP PSSTSRQLSPARH----------------------------------------------- ---------------------------------------------------PAS------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------RSQP----------------- ------------------------------------------------------------ ---------------------------------------------------SPG-STVPR RMAPGRSSELS----------------------------------SSQS--KDRSLSQPK LSLA-------------------------------------------------------- ---------------HTGPDR--------------------------------------- ------------------------------------------------------------ ---------------------------PHA-----------------------------A NS--------------------RGVLPSAPQNQNEG------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------SQS--------------------------------------------- ---------------------------SYEDNST-------------------------- ---------------EIEGPDPRAPTHTAH------------------------------ --------------------------------------AKD------------------- ------------------------------------------------------------ ----------------------TTPSILKPQEK--------------------------- ------GSQPGN---SGNRPQPSH------------------------------------ ------------------------------------------------------------ ------------------------------------------------SGAS-------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------ERPIR---------------------------------- ------------------------------------------------------------ ----------------P------------------------------------------- -----------------------GS-------------------THPRVQVP-------- -------------------------------------------------------GRAG- ---------VQATP--AKKISPSKHPLPP------------------------------- ----------ESQQSVFA-----------------EE-EEENEGTLK-GKE-DSLSTSVK KWPSSSS-PRNNKYADR-NLDRDKAAI--------------------------------- -------------------G------------------QLVQEENSI------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------PG-------------------------------------- -------------------RR----S-P-------------------------------- ------------------------------------------------------------ ------------------------------G------------------SP--PIASHPP TWYQP-----------RNP----------------------------STAS--------- ---------------------------------PSASTHSWPR----------------- --------------YTTRAPSTY------------------------------------- ----SST-T--------------------------------------------------- ------------------------------PML----------SLRQRMQR--------- ---------------RFRTPV-----SRQ-P-----------PP---------------- ------------------------------------------------------------ ---------------------------RPVL------T------S--------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------GYNGRANV----------- --GENNIPIPPGSIGKPNGQRIINGPQGTKWVVDLDRGLVLNAEGRYLQDSHGNPLRVRL GGDGRTIVDLGGTPMVSPDGLPLFGQGRHGKPVASAQDKPILSLGGKPLVGLE--VIKTT TYPP-TT-----TMLP---------PTTTTTVP--------T--TTTRPPTTT---T--- --------TT-----TRR---TTT------------------------------------ ---RRTT-TTRH-------PTTTIR--------ATRR----------------TTT--TT ----------TTPEP-------------TT------------------------------ -PSPTCPPGTLEHQDEAGNLIM-GSNGIPECY--------------------------P- ------------------------EEDDFSGLETD--------TALPTEEDYVVYDD--- ---------------------D--------YG-FE-TTR-------P-----P---T--- -------STMLS-------------------------------------------TTA-- ATPK-----------VIPEQGT----------------------V--------------- -----SSFPEEEFDLAGKRRFV--------------------------APYVTYLSKDPT APCSLTDALDHFQVESLDELIPND--LTKSDLPPQHAPRNITVVAMEGCHSFVIVDWNKA IPGDVVTGYLVYSASYEDFIRNKWSTQTSSVTHLPIENLKPNT----------------- -------------RYYFKVQAKNPHGYGPVSPSVSFVTESDNPLLVVRPPG--------- ------GEPIWIPFAFKHDPGYTDCHGRQYVKRTWYKKFVGVVLCNSLRYKIYLSDNL-K -DTFYSIGDSWGRGEDHCQFVDSHLDGRTGPQSYIEALPNIQGYYRQYRQEPVSFGHIGF GTPYYYVGWYECGVSIPGKW---------------------------------------- ------------------------------------------------------ >MGP_PahariEiJ_P0054924 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------VGLKVTWDPPKDASSRPV----EYYN ------------------------------------------------------I-AYGK S-----------------------------------------------LK---------- -----------SLKSIKVNAETHSFLIKDV------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------EKEVPNKPLRMRVRAS-------------------------------------- -----------------DDRLSVAWKAPRL-SGAKS-------PR-RSRGFLLGYG---- -ESGRKMNY------------VPLTRDERSHEIKKL---ASESV---------------- ---------YVVSLQSTN-----------------SQGQSQPVYRAALTKRKHAEE---- ---EELDVPEDISVRVMSSQSVLVTWVDPLVE-KQKRVV--AS-RQYTVRYREKGESARW DYKQVSNRRVLVDSLIPDTVYEFAVRISQGERDGKWSASIFQRTPESAPTTAPENLRVWP VSGKPTVVTVSWDALSESEGKVKEYILSYAPALKPFGAKSLTFSGHTTSALVDGLEPGER YLFKIRATNRRGLGPHSKAFIVAIPT-----------T-SSTEASAQP--NGRDS----- ---------------------------------------SGKPEKLQHPSSPAPKVAA-- -------SSEHT------------------------------------------------ -----------PSAKNVKDALFDLKNKIRTNGVVPGKIQLHS-KMGEL---DPQS----T EVTG-------EEELDSLEDPRSSRLE-------------TLN----------------- -----------LKQPLRV--PNRSGHGVLAPGRTPARTGLPVLPHKEAMDR-RGPSLDPH --------LR---------------------------------------PRVEPSA---S -------------SA--------------------------------------------- -------------------YHQLSS----------------------------------- ------------------------------------------------------------ -----------------------------------IDN---------------------- ----------------------DPVDQNEYDQ---------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------AASSPSSPKNT---------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------ARSRPTSV----------- ------PSRHAASNMLRDKSRVRPGAKAS----SSSSASRQSHSSTS------------- --------------------------------------EEDSSAAAQ------------- ------PRR---------------------------HFPLQGGS---------SRS---- -------TLSR---DRQDAHTSSSH---------------KPSQTV----SSSHPSALTE GSEEEDT----------------------------------------------------- ------------------------------------------------------------ -------------------------------------------------------SVGGA DIDRAAEVTRRRAEATAQIQQT---------R---------------------------- ------------PALGHFSLIRNKPFPAHSRNPNRFPRLRGPRLQPSRS---PQS---TS ASKVL------------------------------------------------------- --------------------TSAPSLPAS------------------------------- HTRPGSDVYGD--------------------------VEDEEPLP-------------AT ------------------------------------------------------------ ---------------------VVNDR-T------------P-----------------SS S------------------RHPISGGSDTLRRGPHRGASLYRKEPIPENS---------- -------------------------------KAA-------------------------- ----------------------------------------------------------GA --------------------------DVHPGGK--------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------PPLSSKAEGFQLS-TDEGA----PQTP PSSTSRQLSPARH----------------------------------------------- ---------------------------------------------------PAS------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------RSQP----------------- ------------------------------------------------------------ ---------------------------------------------------SPG-STVPR RMAPGHSSELS----------------------------------SSQS--KDRSLSQPK LSLA-------------------------------------------------------- ---------------HTGPDR--------------------------------------- ------------------------------------------------------------ ---------------------------LHA-----------------------------A NP--------------------RGVLPSAPQNQNEG------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------SQS--------------------------------------------- ---------------------------SYEDNST-------------------------- ---------------EIEGPD----THSAR------------------------------ --------------------------------------AKD------------------- ------------------------------------------------------------ ----------------------TTPSILKPQQM--------------------------- ------GSQSGI---SGNRPQTNH------------------------------------ ------------------------------------------------------------ ------------------------------------------------AGAS-------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------ERPIR---------------------------------- ------------------------------------------------------------ ----------------P------------------------------------------- -----------------------GS-------------------THPRAQVP-------- -------------------------------------------------------GRAG- ---------VQAIP--GKTILPSKHPLPP------------------------------- ----------ESQQSVFA-----------------EE-EEENEGILK-GKE-ASLSTSVK KWPSSSS-PRDNKYADR-NLDKDKAAI--------------------------------- -------------------G------------------QLVQEENTI------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------PG-------------------------------------- -------------------RR----S-P-------------------------------- ------------------------------------------------------------ ------------------------------G------------------SP--PVASHPP TRYQP-----------RNP----------------------------ATAS--------- ---------------------------------PIVSTHSWPR----------------- --------------YTTRAPSAY------------------------------------- ----SST-T--------------------------------------------------- ------------------------------PML----------SLRQRMQR--------- ---------------RFRTPV-----SRQ-P-----------PP---------------- ------------------------------------------------------------ ---------------------------RPVL------T------P--------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------GYNGRANV----------- --GEN---IPPGSIGKPNGQRIINGPQGTKWVVDLDRGLVLNAEGRYLQDSHGNPLRVRL GGDGRTIVDLGGTPMVSPDGLPLFGQGRHGKPVASAQDKPILSLGGKPLVGLE--VIKTT TYPP-TT-----TMPP---------TTTTTTVP--------T--TTTRLPTTT---T--- --------TT-----TRR---TTT------------------------------------ ---RRTT-TTRR-------PTTTIR--------ATRR----------------TTT--TT ----------TTPEP-------------TT------------------------------ -PSPTCPPGTLEHQDEAGNLIM-GSNGIPECY--------------------------P- ------------------------EEDDFSGLETD--------TALPTEGDYVVYDD--- ---------------------D--------YG-FE-TTR-------P-----P---T--- -------STMPS-------------------------------------------TTA-- ATPK-----------VIPEQGT----------------------V--------------- -----SSFPEEEFDLAGKRRFV--------------------------APYVTYLSKDPA APCSLTDALDHFQVESLDELIPND--LTKSELPPQHAPRNITVVAMEGCHSFVIVDWNKA IPGDVVTGYLVYSASYEDFIRNKWSTQTSSVTHLPIENLKPNT----------------- -------------RYYFKVQAKNPHGYGPVSPSVSFVTESDNPLLVVRPPG--------- ------GEPIWIPFAFKHDPGYTDCHGRQYVKRTWYKKFVGVVLCNSLRYKIYLSDNL-K -DTFYSIGDSWGRGEDHCQFVDSHLDGRTGPQSYIEALPTIQGYYRQYRQEPVSFGHIGF GTPYYYVGWYECGVSIPGKW---------------------------------------- ------------------------------------------------------ >ENSRNOP00000073034 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------------MA-------- ---PEARA---SPRLLLR-AA-LLLLAALLPVASSAG-PP-------------------- ------------------------------------------------VDHPL------- -----------------------KPRHVKLLSANMGLKVTWDPPKDATSRPV----EHYN ------------------------------------------------------I-AYGK S-----------------------------------------------LK---------- -----------SLKSIKVNAETHSFLIKDV--------------------------EPGV VYFVLVTAENHS--------GVSRPVYRAESPP--------------------------- -------------------------------------------------------GG--- ---------------------------------EWIKIDGFPNKGPGP------------ ------------------FNETIT------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------EKEVPNKPLRMRVRAS-------------------------------------- -----------------DDRLSVAWKAPRL-SGAKS-------PR-RSRGFLLGYG---- -ESGRKMNY------------VPLTRDERSHEIKKL---ASESV---------------- ---------YVVSLQSTN-----------------SQGQSQPVYRAALTKRKNAEE---- ---DELDVPEDISVRVMSSQSVLVAWVDPLVE-KQKRVV--AS-RQYTVRYREKGESARW DYKQVSNRRALVDSLIPDTVYEFAVRISQGERDGKWSASVFQRTPESAPTTAPENLRVWP VNGKPTVVTVSWDALPESEGKVKEYILSYAPALKPFGAKSLTFSGHTTSALVDGLQPGER YLFKIRATNRRGQGPHSKAFIVAIPT-----------T-SSTEASVQP--NGRDN----- ---------------------------------------G-KPEKPQQPSSSAPKVAA-- -------SSQHM------------------------------------------------ -----------PPAKNVKDALSDLKNKIQTNGVAPGRTQLHS-KVGEL---DPQS----T EVTG-------EEELDSLENPRSSRLE-------------TLN----------------- -----------QKQPLRV--PSRSGHGALAPGRTPARAGLPVLSRKEGMDR-RGPSLDPH --------PH---------------------------------------PRVEPSA---S -------------SA--------------------------------------------- -------------------YHQLSS----------------------------------- ------------------------------------------------------------ -----------------------------------TDN---------------------- ----------------------DSVDRKEDDQA---------GSPD-------------- ------------------------------------------------------------ -----------------PK----------------------------------------- ---------------AASSGSSPKNP---------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------GRSRPTSA----------- ------PSRHAASNMLRDKSRVHPGTKA-----ASSSTSRQSHSSTS------------- --------------------------------------EEDSSA--Q------------- ------PSR---------------------------HFPLHRGS---------STS---- -------PLSRGWKDRQDTHASSSH---------------TTSRTA----SSSHPSALTE GSEEED------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------------------GGA DSDRAAEDTIRRAEATAQIQQT---------R---------------------------- ------------PGLGHFSLIRNKPFTPHSRNPNRFPRLRGPRLQPSVS---PQS---TS ASKVL------------------------------------------------------- --------------------TRSPSLPAS------------------------------- HTRPGSDVYGD--------------------------GEDEEPLP-------------AT ------------------------------------------------------------ ---------------------VINDR-T------------P-----------------SY P------------------RHPISGSSDTLRRGPQRGASLYRKEPIPENS---------- -------------------------------KAA-------------------------- ----------------------------------------------------------GA --------------------------DVPPGGR--------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------SPLSSKAQGFQQSTTDEGA----PQTS PASTSRQPSPARP----------------------------------------------- ---------------------------------------------------PAS------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------RSQP----------------- ------------------------------------------------------------ ---------------------------------------------------SPG-STVPR RMTPDRSSELS----------------------------------SSQS--KDRSLSQPK LSVA-------------------------------------------------------- ---------------HAGHDH--------------------------------------- ------------------------------------------------------------ ---------------------------PHT-----------------------------A NS--------------------RGVLPSAPQNQNEG------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------AQS--------------------------------------------- ---------------------------TYEDNST-------------------------- ---------------EIEGPDSRTPTHSAR------------------------------ --------------------------------------AKD------------------- ------------------------------------------------------------ ----------------------TTPPILKPRQV--------------------------- ------GSQSWS---SDNRPQPSQ------------------------------------ ------------------------------------------------------------ ------------------------------------------------AGAS-------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------ERPIR---------------------------------- ------------------------------------------------------------ ----------------P------------------------------------------- -----------------------GS-------------------THPRAQVP-------- -------------------------------------------------------GRAG- ---------VQATS--VKKVSPSKRPLPL------------------------------- ----------ESQQSVFA-----------------EE-EEENEGMLK-GKE-DSLSTSVK KWPSSSS-PRD-KYADR-NLDKDKAAI--------------------------------- -------------------G------------------LLVQEENTV------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------PG-------------------------------------- -------------------RR----P-P-------------------------------- ------------------------------------------------------------ ------------------------------G------------------SP--AIASHPS TRHQP-----------RNP----------------------------ATAS--------- ---------------------------------PIANTHSWPR----------------- --------------YTTRAPSSY------------------------------------- ----SST-T--------------------------------------------------- ------------------------------PML----------SLRQRMQR--------- ---------------RFRTPV-----SRQPP-----------PP---------------- ------------------------------------------------------------ ---------------------------RPVL------T------P--------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------GYNGRPNA----------- --EEN---IPPGSIGKPNGQRIINGPQGTKWVVDLDRGLVLNAEGRYLQDSHGNPLRVRL GGDGRTIVDLGGTPMVSPDGLPLFGQGRHGKPVASAQDKPILSLGGKPLVGLE--VVRTT TQVP-TT-----TMPP---------STTTTTVP--------P--TTT-LPPTT---T--- --------TT-----RRT---TTT------------------------------------ ---RRTT-TTRR-------PTTTTR--------ATRR----------------TTT--TT ----------TTPEP-------------TT------------------------------ -PSPTCPPGTLEHRDEAGNLIM-GSNGIPECY--------------------------P- ------------------------EEDDFSGLEID--------TALPTEEDYVVYDD--- ---------------------D--------YG-LE-TTR-------P-----P---T--- -------STMPS-------------------------------------------TTA-- ATPK-----------VVPEQGT----------------------V--------------- -----SSFPEEEFDLAGKRRFV--------------------------APYVTYLSKDPA APCSLTDALDHFQVESLDELIPND--LTKNDLPPQHAPRNITVVAMEGCHSFVIVDWNKA IPGDVVTGYLVYSASYEDFIRNKWSTQTSSVTHLPIENLKPNT----------------- -------------RYYFKVQAKNPHGYGPVSPSVSFVTESDNPLLVVRPPG--------- ------GEPIWIPFAFKHDPGYTDCHGRQYVKRTWYKKFVGVVLCNSLRYKIYLSDNL-K -DTFYSIGDSWGRGEDHCQFVDSHLDGRTGPQSYVEALPTIQGYYRQYRQEPVSFGHIGF GTPYYYVGWYECGVSIPGKW---------------------------------------- ------------------------------------------------------ >ENSMUGP00000009396 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------------MA-------- ---PEARA---SPSPLLPWAA-LLLWAALLPVASLAG-PP-------------------- ------------------------------------------------VDHPL------- -----------------------KPRHVKLLSAKTGLKVMWDPPKDATSRPV----EHYN ------------------------------------------------------I-AYGK S-----------------------------------------------LK---------- -----------SLKYIKVNAETYSLLIEDV--------------------------EPGV VYFVLVTAENHS--------GVSRPVYRAESPP--------------------------- -------------------------------------------------------GG--- ---------------------------------EWIKIDGFAIKGPGP------------ ------------------FNETTT------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------EKEVPNKPLRMRVRAS-------------------------------------- -----------------DDRLSVAWKAPRL-SGAKS-------PR-RSRGFLLGYG---- -ESGRKMNY------------VPLTRDERSHEIKKL---ASESV---------------- ---------YVVSLQSTN-----------------SQGQSQPVYRAALTKRKNAEA---- ---DELDVPEDISVRVMSPQSVLVTWVDPLVE-KQKRVV--AS-RQYTVRYREKGESARW DYKQVSNRRALVDSLIPDTVYEFAVRISQGERDGKWSASIFQRTPESAPTTAPENLNVWP VSGKPTTVTVSWDALPETEGKVKEYILSYAPALKPFGAKSLTFSGHTTSALVDGLQPGER YLFKIRATNRRGPGPHSKAFIVAIPT-----------T-SSTEASAQP--NGRDSWKHEK PQPSSPTPKAAASSDRSTPAKNVKDALPDSKNKILANGGA-------------------- ------------------------------------------------------------ ---------------------------------VPRKTQLHP-KTGEL---DPQS----T EVTG-------EEELDSLEDPRSSRLA-------------TLD----------------- -----------QRRPLRV--PSRSGHWVPAPGRIPARPGLPVLPRKEGLDK-RGPSLAPN --------PRLGVD-------------SS--------------VAATSG----------- ------------------------------------------------------------ -------------------YHRLSP----------------------------------- ------------------------------------------------------------ -----------------------------------TDN---------------------- ----------------------DSMDQDEDEQA---------ASPD-------------- ------------------------------------------------------------ -----------------PK----------------------------------------- ---------------AASSQSPPKNPIRSELTPAAGR----------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------LAASTVLRDKS------------RSASH------------------- -----------------------------------------SHSSTS------------- --------------------------------------EENSSAAAQ------------- ------PSR---------------------------HFPLHRGSSRPLPSHPHSRS---- -------PLSKGWRDRQDTHASSSH---------------IPTRAA----GSSHPSSLTV GSEEDDV----------------------------------------------------- ------------------------------------------------------------ -------------------------------------------------------SGGVG DSDRGAEDTRKRAEATAQTQQT---------R---------------------------- ------------PALGHFSLIRNKPFAGHSRNPNRFPRLRGLRLQPSGA---PPS---TS ASKVL------------------------------------------------------- --------------------TRAPAQPAS------------------------------- HSRPSPNVYGD--------------------------GEDEEPLP-------------AT ------------------------------------------------------------ ---------------------VVSDRTT------------P-----------------SF S------------------RQPVSGGWDTLRRGSQRGSSVYQKEPVLENS---------- -------------------------------KTA-------------------------- ----------------------------------------------------------GA --------------------------DVHSGGK--------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------SPLPSKAQDFEQS-T-EDA----PQTS PGATSRQPSPARP----------------------------------------------- ---------------------------------------------------PAS------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------RSQP----------------- ------------------------------------------------------------ ---------------------------------------------------SPG-STAPR RTTPGRHSELS----------------------------------SSQSHGDDRSLSQPK LSVA-------------------------------------------------------- ---------------Q-------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------EGRERLRT------------------ ------------------------------------------------------------ ----------------------------------------------------VNSHQAL- ----------------------PLA--------------------------------SQG QD---------------------------------------------------------- ----------EDSQS--------------------------------------------- ---------------------------SYEDNST-------------------------- ---------------EIEGPDSRAPTHSAR------------------------------ --------------------------------------AKD------------------- ------------------------------------------------------------ ----------------------ATPSVFKPRQA--------------------------- ------SSQSGN---SDSRPQPNH------------------------------------ ------------------------------------------------------------ ------------------------------------------------AGAS-------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------VRPSR---------------------------------- ------------------------------------------------------------ ----------------P------------------------------------------- -----------------------GS-------------------AQPRAQGP-------- -------------------------------------------------------GRAG- ---------LQATP--GKKISPSKRPLPL------------------------------- ----------ESQQSVFT----------------EEE-EEENEGNLK-DKE-NSLSTSVS KWPSSSS-PRDNKYANR-NLDKDKAATGLAPQ---------------------------- ------------------GG------------------SLVQEESTI------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------PG-------------------------------------- -------------------RR---PP-P-------------------------------- ------------------------------------------------------------ ------------------------------G------------------SP--PIASHPS TRYQP-----------RNP----------------------------ATAS--------- ---------------------------------PTASTHSWPR----------------- --------------YTTRAPPSY------------------------------------- ----SST-T--------------------------------------------------- ------------------------------PML----------SLRQRMQR--------- ---------------RFRTPV-----SRQ-------------PP---------------- ------------------------------------------------------------ ---------------------------RPVL------T------S--------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------GYNGRPNA----------- --EEN---IPPGSIGKPNGQRIINGPQGTKWVVDLDRGLVLNAEGRYLQDSHGNPLRVRL GGDGRTIVDLGGTPMVSPDGLPLFGQGRHGKPLASAQDKPILSLGGKPLVGLE--VIKTT TRPP-TT-----TMPP---------TTTTTTVP--------T--TTTLQP--T---T--- --------TT-----TRR---TTT------------------------------------ ---RRTT-TTRR-------PTTTVR--------ATRR----------------TTT--TT ----------TTPEP-------------TT------------------------------ -PSPTCPPGTLEKQDEAGNLIM-ASNGIPECY--------------------------P- ------------------------EEDDFSGLETD--------TALPMEEDYVVYDD--- ---------------------D--------YG-LV-TTM-------P-----P---A--- -------STMPS-------------------------------------------TTA-- ATPN-----------IIPEQGT----------------------V--------------- -----SSFPEEEFDLAGKRRFV--------------------------APYVTYLSKDPS APCSLTDALDHFQVESLDELIPND--LTKNDLPPQHAPRNITVVAMEGCHSFVIVDWNKA VPGDVVTGYLVYSASYEDFIRNKWSTQTSSVTHLPIENLKPNT----------------- -------------RYYFKVQAKNPHGYGPVSPSVSFVTESDNPLLVVRAPG--------- ------GEPIWIPFAFKHDPGYTDCHGRQYVKRTWYKKFVGVVLCNSLRYKIYLSDNL-K -DTFYSIGDSWGRGEDHCQFVDSHLDGRTGPQSYIEALPTIQGYYRQYRQEPVSFGHIGF GTPYYYVGWYECGVSIPGKW---------------------------------------- ------------------------------------------------------ >ENSJJAP00000017596 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------MGLKVTWDPPKDVSSRPV----EHYS ------------------------------------------------------I-AYGK S-----------------------------------------------LK---------- -----------SLKHIKVNAETYSFLIEDV------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------EKEVPNKPLRMRVRPS-------------------------------------- -----------------EDRLSVAWKAPRL-SGAKS-------PR-RSRGFLLGYG---- -ESGRKMNY------------VPLSRDERTHEIKKL---ASESV---------------- ---------YVVSLQSMN-----------------SQGRSQPVYRAALTK-----QVSCH APTDELDVPKDISVRVMSSQSMLVAWVDPLVE-KQKRVV--AS-RQYTVRYREKGESARW DYKQVANRRALVDNLIPDTVYEFAVRISQGERDGKWSTSVFQRTPESAPTTAPENLNVWP VSGKPTVVTASWDPLPETEGKVKEYILSYAPALKPFGAKSLTFPGRTTSALVDGLQPGER YLFKIRAANRRGPGPHSKAFIVAIPTSDSEPRV-----------------HTEENWKPRN LG----------------------------------------------PASPAPKAPA-- -------SSDHT------------------------------------------------ -----------ARGRNVKDALLDLKNKILANGGVLRKPQPRP-KTGEL---ALQS----T EVTGE------EEEVDSLEGPRASPSE-------------TQD----------------- -----------QRLALRP--PSRPGHWVPAPGRPPSRAGSSVLTRKEGVDR-HGPSQASH --------PR---------------------------------------HRVSPSGEA-S SAHHQ------------------------------------------------------- ------------------------------------------------------P----- ------------------------------------------------------------ ------------------------SSI---------DN---------------------- ----------------------DSVDSDED------------------------------ ----------VQT--------------------------------DIPHPKA-------- ---------TSSSQPLPPR----------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------------NAAQR----- -RPDLSPSRLAFPGISRDRSPVQLGAKPASPT-------------------RRRP----- --------HA------------------------SPSGEEDPIAPAP------------- ------PSR---------------------------LSPSHTGSSR---SQAPPRP---- -------PLSRGWKDAQ------------------------------------------- ------------------------------------------------------------ -----------------------------------------ASSSRTAASP--------- --SRTEASE------------------------------------------EGDASDGGV GGDRRAEEPERQAEVTVPTQRA---------R---------------------------- ------------PAPGHLGLLRNKPFAANARTPHRSPSGRGLATQPSGSLARP------- ------------------------------------------------------------ -------------------------QPDS------------------------------- HPRLGSDVHGD--------------------------GDNEEPLA-------------AT ------------------------------------------------------------ ---------------------VVNKH-V------------S-----------------SS S------------------RLP--GGWDP-RRGPQRGTSLYRKEPIPENP---------- -------------------------------ESA-------------------------- ----------------------------------------------------------ET --------------------------DERPESKS-------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------SSLPPKAQDIQQS-TDM---------- --AMGRRGSPARP----------------------------------------------- ---------------------------------------------------PPV------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------RLQP----------------- ------------------------------------------------------------ ---------------------------------------------------YPG-SSVPR RMAPGRQHEVS----------------------------------MPQGKDAERSLSQPK LALA----------------------------PTSQ------------------------ ------------------------------------------------------------ ----------------------D------------------------------------- ---------------------------PHT-----------------------------A SS--------------------RGVLRSAPRGQ--------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -D---------------------------------------------------------- ----------GNSQD--------------------------------------------- ---------------------------SYDDNST-------------------------- ---------------EVEDPDGQTPAHADR------------------------------ --------------------------------------TKD------------------- ------------------------------------------------------------ ----------------------ATPALFKHRHV--------------------------- ------GSPVEN---SEDR----------------------------------------- ------------------------------------------------------------ ---------------------------------------------------S-------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------PRPSR---------------------------------- ------------------------------------------------------------ ----------------P------------------------------------------- -----------------------GS-------------------AHPRLRVP-------- -------------------------------------------------------GKTG- ---------VQASP--GKKTPPSKHPQPP------------------------------- ----------KSQQSVSAEE---------------EE-EEEDEGFLK-GKE-DLLSASAS KW--SST-SRGSKYGDR-GVDKDKAAIAIAPR---------------------------- -------------------G------------------SPVQEERDT------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------PG-------------------------------------- -------------------KRPHAPP-P-------------------------------- ------------------------------------------------------------ ------------------------------G------------------GP--PMASRPP T---P-----------RPP----------------------------GSSD--------- ---------------------------------PIAGTHSWPR----------------- --------------HTTRAPPSY------------------------------------- ----SST-T--------------------------------------------------- ------------------------------PML----------SLRQRMQR--------- ---------------RFRTPV-----SRQ-------------PV---------------- ------------------------------------------------------------ ---------------------------RPSH------T------Q--------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------GYNGRPNV----------- --EEK---IPPGSIGKPNGQRIINGPQGTKWVVDLDRGLVLNAEGRYLQDSHGNPLRVKL GGDSRTIVDLGGTPVVSPDGLPLFGQGRHGKPLASAQDKPILSLGGKPLVGLE--VIRTT THPP-PT-----TMAPS--------TTTTTTVP--------T--TTTPKPT-----T--- --------TT-----TRR---TTT------------------------------------ ---RRTT-TTTR-------PTTTVR--------TTRRTTTTS--ATTTTTTTTTTT--TT ----------TTPEP-------------ST------------------------------ -PAPTCPPGTLEQHDEDGNLIV-GSSGIPECS--------------------------P- ------------------------EKDEFSGQEAD--------TAVPTEEAYVVYDE--- ---------------------D--------YE-SE-TTR-------P-----P---P--- -------TTVRL-------------------------------------------TTA-- ATPK-----------VIPEEGT----------------------V--------------- -----SSFPEEEFDLAGKKRFV--------------------------APYVTYLSKDPS APCSLTDALDHFQVDSLDEIIPSD--LRKGDLPPQHAPRNITVVAMEGCHSFVIVDWNKA TPGDVVTGYLVYSASYEDFIRNKWSTQDSSVTHLPIENLKPNT----------------- -------------RYYFKVQAKNTHGYGPISPSVSFVTESDNPLLVVRPPG--------- ------GEPIWIPFAFKHDSSYTDCHGRQYVKRTWYRKFVGVVLCNSLRYKIYLSDNL-K -DTFYSIGDSWGRGEDHCQFVDSHLDGRTGPQTYIEALPNIQGYHRQYRQEPVSFGHIGF GTPYYYVGWYECGVTIPGKW---------------------------------------- ------------------------------------------------------ >ENSVURP00010023387 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------------MALTGRAYRL PGLP------------------LLFLAALVYLAS-AE-AA-------------------- ------------------------------------------------VDHPL------- -----------------------KPRNVRLQSTKRGLKVTWEPPKEATIRPV----EYYN ------------------------------------------------------I-AYGK S-----------------------------------------------LK---------- -----------NLSYIKVNGDTHSFLIEDV--------------------------EPGV VYFVLVTSENHS--------GVSRPVYRAESLL--------------------------- -------------------------------------------------------GG--- ---------------------------------EWIKIDGFAFKGPEP------------ ------------------LNETMT------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------EKEVPNKPLRVRVRSS-------------------------------------- -----------------DDKLSVQWKAPRA-SGVKS-------PR-RSQGFLLGYG---- -ESGRKMNY------------VPLTRDERAHEIKKL---ASESV---------------- ---------YVVSLQSMN-----------------SQGQSQPVYRAALTKRKTEEE---- ---DELEEPEDINVRVMSSQSVLVAWVDPVLE-KQKRTV--AS-RQYTVRYREKGESARW DFKQVAGRRTLIENLIPDTMYEFAVRISQGERDGKWSTSVFQRTPESAPTTAPENLDVHP VKGKPTAVTVSWDALQETEGRVREYILSYAPALKPFGAKSLTYPGETTSAIVDGLQPGER YLFKIRAANRRGQGPQSKAFIVAMPT-----------T-VTSDPNAHQRMDMEDKLDPKK PE----------------------------------------------PSQKV----P-- -------PSKHIH-S--------------------------------------------- --------PLSPKGRDAKTSLPDLKNKLVTNSDVHSKSHLPPKKRTEL-GSDLQS----T EVTD--------DDLDSHSESPVSQSK-------------IQD----------------- -----------TKRNVRPPLPSRSFHSVLGPGRSPVRARIPTLPQKTNID---------- -----------------------------------------------------------S ---------------------------RDSSSSSQDSQSASTSPSSSSFH---DD----- --------ETRHLRMHNSH-----------------------------------P----- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------SSRVTSVNPSHENTNNDPVDDDDDDDKKERHIKDPLHSK--------- ------------------------------------------------------------ -------------------------------YPSSGKPV-----SKTTEHSRLTIPSNRQ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------SVPHQEKSPTHGEGKSHLPAHT NAPSENWEEKSSFLI--------------------------------------------- ------------------------------PATRTSS----------------------- ------------------------------------------------------------ ----------------------------------------HGGAPRALPTRF--GS---- ------------------------------------------------------------ -------------------------------------------HPRVLKNDQEARAVNSA VPSQSTVSSPARHRATHSHLPSMKQTPDERNG---------------------------- -------------------------------------------------------SDDDG NEDYDAEDKKRQTDSTSPTFRS---------RLAA------------------------- ----------GQPFSGNLNFPRRRPFSSASRYPNRVSGSQGPRSQPSSS---PQS---TT SSRVH------------------------------------------------------- ------------------------SHRIS------------------------------- DPRVSSNIDRDEEER--------------------EEDDEEKPLP-------------ST ------------------------------------------------------------ ---------------------IVNDY-L------------P-----------------SS S------------------RQPSSQSSDPIRRIPQRVSSVHRKAPVIENA---------- -------------------------------KS--------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------PLTSQSSS-SDAHSQGNSPS---------------------------- ---------------------FPNKLQTQDTHRNTGTEGLPARV------RPST------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------RSQH----------------- ------------------------------------------------------------ ---------------------------------------------------QSG-SSVPT KV---------------------------------------------------------- ----------------MNVQDSRSAAVSSERHPSSH------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------LSTSKHQLHDHQGKEVENPLSKSKQLHSIPGNSYSSS QD--------------------------VHSNSRPSFKPRTGQSTLSANSRGQLSSHTSQ QSHQESESRYDDSQN-------------------------------------Y------- --------------------------------ST-------------------------- ---------------QLEDQDVRINTHSTH------------------------------ --------------------------------------HKD------------------- -----------------------------------------------GL----------- ---------------------SPTSSLSKQEQM--------------------------- ------GTQSRN---ADEKSQNRH------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------TSSPSSRGSGSSLPAGR-----SGSSR---- -----------ETYAKPTLPFV-----------------------HSRARAP-------- -------------------------------------------------------SRTTS P-VEKKDSLYQSTP--SKREPPSKSPLSSSL----------------------------- ----------KSHQSVSNDDDEDDDD-REYIRRNKEE---------------DSISSSVS KWSPSS----GGKYINR-NVGKDK---------EKSVSSLF------------------- --------------------------------------------------------PHRV ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------------R SNE--------------------------------------------------------- ----------------------EESST--------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------PF-------------------------------------- -------------------KRPIPPL---------------------------------- ------------------------------------------------------------ -----------------------------LG------------------ST--PRTSQIT --------NAPSKFLPRSR----------------------------DTQSPISSTPLHT ------------------------------------------------------------ ---------------TTHVPLTY------------------------------------- ----SST-T--------------------------------------------------- ------------------------------PML----------SLRQRMLN--------- ----S----------RLRNSP-----SRY-------------PA---------------- ------------------------------------------------------------ ---------------------------RPPY------R------P--------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------GNNGRPNV----------- --DGK---ILPGSNGQLSGQRIINGPQGTKWIVDLDWGLVLNSEGRYLQDSHGNPLRVKL GGDGRTIVDMGGTPVVSPDGLPLFGQGRHGKPLASAQDKPVLSLGGKPLMGLE--VIKTT KTP--TT----------------------------------------------------- ------------------------------------------------------------ ---------TTH-------PTTTKA------------TTTTTTTTTTTTTTTPATT--TT -----TTPEPTTPEP-------------TI------------------------------ -PVPTCPPGTLAQHDDYGNLLM-GADGMPECY--------------------------P- ------------------------EEDNFSGLETD--------TAIPTEEAYVVYDE--- ---------------------D--------YE-FE-TTL-------P-----P---T--- -------TTKSS-------------------------------------------TTT-T AEPK-----------VISPEGS----------------------I--------------- -----SSFPEEEFDLAGKKRFV--------------------------APYVTYLNKDPL APCSLTEALDHFQVESLDEIIPSD--LTKSDLPPQHTPRNITVVAVEGCHSFVIVDWDKS TQGDVVTGYLVYSASYEDFIRNKWSTQSSGVTHLPIENLKPNT----------------- -------------RYYFKVQAKNPYGYGPISPSVSFVTESDNPLLVVRPPG--------- ------GEPIWIPFAFKRDPSYTDCHGRQYVKRTWYRKFVGVVLCNSLRYKIYLSDNL-K -DTFYSIGDSWGRGEDHCQFVDSHLDGRTGPQSYVDALPTVQGYHRQYRQEPVGFGRIGF GTPYYYVGWYECGVSIPGKW---------------------------------------- ------------------------------------------------------ >ENSVURP00010024737 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------------MALTGRAYRL PGLP------------------LLFLAALVYLAS-AE-AA-------------------- ------------------------------------------------VDHPL------- -----------------------KPRNVRLQSTKRGLKVTWEPPKEATIRPV----EYYN ------------------------------------------------------I-AYGK S-----------------------------------------------LK---------- -----------NLSYIKVNGDTHSFLIEDV--------------------------EPGV VYFVLVTSENHS--------GVSRPVYRAESLL--------------------------- -------------------------------------------------------GG--- ---------------------------------EWIKIDGFAFKGPEP------------ ------------------LNETMT------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------EKEVPNKPLRVRVRSS-------------------------------------- -----------------DDKLSVQWKAPRA-SGVKS-------PR-RSQGFLLGYG---- -ESGRKMNY------------VPLTRDERAHEIKKL---ASESV---------------- ---------YVVSLQSMN-----------------SQGQSQPVYRAALTKRKTEEE---- ---DELEEPEDINVRVMSSQSVLVAWVDPVLE-KQKRTV--AS-RQYTVRYREKGESARW DFKQVAGRRTLIENLIPDTMYEFAVRISQGERDGKWSTSVFQRTPESAPTTAPENLDVHP VKGKPTAVTVSWDALQETEGRVREYILSYAPALKPFGAKSLTYPGETTSAIVDGLQPGER YLFKIRAANRRGQGPQSKAFIVAMPT-----------T-VTSDPNAHQRMDMEDKLDPKK PE----------------------------------------------PSQKV----P-- -------PSKHIH-S--------------------------------------------- --------PLSPKGRDAKTSLPDLKNKLVTNSDVHSKSHLPPKKRTEL-GSDLQS----T EVTD--------DDLDSHSESPVSQSK-------------IQD----------------- -----------TKRNVRPPLPSRSFHSVLGPGRSPVRARIPTLPQKTNID---------- -----------------------------------------------------------S ---------------------------RDSSSSSQDSQSASTSPSSSSFH---DD----- --------ETRHLRMHNSH-----------------------------------P----- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------SSRVTSVNPSHENTNNDPVDDDDDDDKKERHIKDPLHSK--------- ------------------------------------------------------------ -------------------------------YPSSGKPV-----SKTTEHSRLTIPSNRQ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------SVPHQEKSPTHGEGKSHLPAHT NAPSENWEEKSSFLI--------------------------------------------- ------------------------------PATRTSS----------------------- ------------------------------------------------------------ ----------------------------------------HGGAPRALPTRF--GS---- ------------------------------------------------------------ -------------------------------------------HPRVLKNDQEARAVNSA VPSQSTVSSPARHRATHSHLPSMKQTPDERNG---------------------------- -------------------------------------------------------SDDDG NEDYDAEDKKRQTDSTSPTFRS---------RLAA------------------------- ----------GQPFSGNLNFPRRRPFSSASRYPNRVSGSQGPRSQPSSS---PQS---TT SSRVH------------------------------------------------------- ------------------------SHRIS------------------------------- DPRVSSNIDRDEEER--------------------EEDDEEKPLP-------------ST ------------------------------------------------------------ ---------------------IVNDY-L------------P-----------------SS S------------------RQPSSQSSDPIRRIPQRVSSVHRKAPVIENA---------- -------------------------------KS--------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------PLTSQSSS-SDAHSQGNSPS---------------------------- ---------------------FPNKLQTQDTHRNTGTEGLPARV------RPST------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------RSQH----------------- ------------------------------------------------------------ ---------------------------------------------------QSG-SSVPT KV---------------------------------------------------------- ----------------MNVQDSRSAAVSSERHPSSH------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------LSTSKHQLHDHQGKEVENPLSKSKQLHSIPGNSYSSS QD--------------------------VHSNSRPSFKPRTGQSTLSANSRGQLSSHTSQ QSHQESESRYDDSQN-------------------------------------Y------- --------------------------------ST-------------------------- ---------------QLEDQDVRINTHSTH------------------------------ --------------------------------------HKD------------------- -----------------------------------------------GL----------- ---------------------SPTSSLSKQEQM--------------------------- ------GTQSRN---ADEKSQNRH------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------TSSPSSRGSGSSLPAGR-----SGSSR---- -----------ETYAKPTLPFV-----------------------HSRARAP-------- -------------------------------------------------------SRTTS P-VEKKDSLYQSTP--SKREPPSKSPLSSSL----------------------------- ----------KSHQSVSNDDDEDDDD-REYIRRNKEE---------------DSISSSVS KWSPSS----GGKYINR-NVGKDK---------EKSVSSLF------------------- --------------------------------------------------------PHRV ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------------R SNE--------------------------------------------------------- ----------------------EESST--------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------PF-------------------------------------- -------------------KRPIPPL---------------------------------- ------------------------------------------------------------ -----------------------------LG------------------ST--PRTSQIT --------NAPSKFLPRSR----------------------------DTQSPISSTPLHT ------------------------------------------------------------ ---------------TTHVPLTY------------------------------------- ----SST-T--------------------------------------------------- ------------------------------PML----------SLRQRMLN--------- ----S----------RLRNSP-----SRY-------------PA---------------- ------------------------------------------------------------ ---------------------------RPPY------R------P--------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------GNNGRPNV----------- --DGK---ILPGSNGQLSGQRIINGPQGTKWIVDLDWGLVLNSEGRYLQDSHGNPLRVKL GGDGRTIVDMGGTPVVSPDGLPLFGQGRHGKPLASAQDKPVLSLGGKPLMGLE--VIKTT KTP--TT----------------------------------------------------- ------------------------------------------------------------ ---------TTH-------PTTTKA------------TTTTTTTTTTTTTTTPATT--TT -----TTPEPTTPEP-------------TI------------------------------ -PVPTCPPGTLAQHDDYGNLLM-GADGMPECY--------------------------P- ------------------------EEDNFSGLETD--------TAIPTEEAYVVYDE--- ---------------------D--------YE-FE-TTL-------P-----P---T--- -------TTKSS-------------------------------------------TTT-T AEPK-----------VISPEGS----------------------I--------------- -----SSFPEEEFDLAGKKRFV--------------------------APYVTYLNKDPL APCSLTEALDHFQVESLDEIIPSD--LTKSDLPPQHTPRNITVVAVEGCHSFVIVDWDKS TQGDVVTGYLVYSASYEDFIRNKWSTQSSGVTHLPIENLKPNT----------------- -------------RYYFKVQAKNPYGYGPISPSVSFVTESDNPLLVVRPPG--------- ------GEPIWIPFAFKRDPSYTDCHGRQYVKRTWYRKFVGVVLCNSLRYKIYLSDNL-K -DTFYSIGDSWGRGEDHCQFVDSHLDGRTGPQSYVDALPTVQGYHRQYRQEPVGFGRIGF GTPYYYVGWYECGVSIPGKW---------------------------------------- ------------------------------------------------------ >ENSPCIP00000049292 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------------MALTGRASRL PGLP------------------LLFLAALVYLAS-AE-AP-------------------- ------------------------------------------------VDHPL------- -----------------------KPKNVRLQSTKRGLKVTWEPPKEATTRPV----EYYN ------------------------------------------------------I-AYGK S-----------------------------------------------LK---------- -----------NLSYIKVNGDTHSFLIEDV--------------------------EPGV VYFVLVTSENHS--------GVSRPVYRAESLL--------------------------- -------------------------------------------------------GG--- ---------------------------------EWIKIDGFAIKGPEP------------ ------------------LNETVT------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------EKEVPNKPLRVRVRSS-------------------------------------- -----------------DEKLSVQWKAPRA-SGVKS-------PR-RSQGFLLGYG---- -ESGRKMNY------------VPLTRDERAHEIKKL---ASESV---------------- ---------YVVSLQSVN-----------------SQGQSQPVYRAALTKRKTEEE---- ---DELEEPEDINVRVMSSQSVLVAWVDPILE-KQKRTV--AS-RQYTVRYREKGESARW DYKQVAGRRTLIENLIPDTMYEFAVRISQGERDGKWSTSVFQRTPESAPTTAPENLDVRP VKGKQTAVTASWDALPETEGRVKEYILSYAPALKPFGAKSLTYPGKTTSAIVDGLQPGER YLFKIRAANRRGQGPQSKAFIVAMPT-----------T-VTSDPNAHQRMNMEDKLDPKK PE----------------------------------------------PSQKV----P-- -------PSKHIH-S--------------------------------------------- --------PLSPKGRDAKTPLPDLKNKFLTNSEVLSKSQLPPKKRTEL-GSDLQS----T EVTD--------DDLDSHSESPASQSK-------------IQD----------------- -----------TKRNVRPPLPSRSFHSVLGPGRTPVRARIPTLPQKTNID---------- -----------------------------------------------------------S ---------------------------HDSSSSSQDSQSASTSPSSSSFH---DD----- --------ETRHLRMRNSH-----------------------------------P----- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------SSRVTSVNPSHENTSNDPVDDDDDDDKKERHIKDPLHSK--------- ------------------------------------------------------------ -------------------------------YPSSGKPV-----SKTTERSRLTVPSNRQ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------PVLHQEKSPTHGEGKSHLPAHT NAPSENWEEKSSFLI--------------------------------------------- ------------------------------PATRTSS----------------------- ------------------------------------------------------------ ----------------------------------------PGGAPRALPTRF--GS---- ------------------------------------------------------------ -------------------------------------------HPRVLKNDQEARAVNSA MPSQSTVSSPARHRATHSHLPSMRQTPDERNG---------------------------- -------------------------------------------------------SDDDG NEDYDAEDKKRQTDSTSPTFRS---------RLAT------------------------- ----------GQPISGNLNFPRRRPFSSSSRYPNRVSSSQGPRSQPSSS---PQS---TT SSRVH------------------------------------------------------- ------------------------SHRIS------------------------------- DPRVGSNIDRDEEEK--------------------EEDDEEKPLP-------------ST ------------------------------------------------------------ ---------------------VVNDY-L------------P------------------S S------------------RQPSSQSSDHIRRIPQRVSSVHRKAPVMENA---------- -------------------------------KS--------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------PLTSQSSS-SEAHSQGNSPS---------------------------- ---------------------FPNKLHTQDAHRNTGTVGIPARV------RPFM------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------RSQH----------------- ------------------------------------------------------------ ---------------------------------------------------QSG-SSAPT KV---------------------------------------------------------- ----------------MKVQDSRSAALSSERHPSSH------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------LSTSKHQLHDHQGKEVENPLSKSKQWHSIPGNSYSSS QD--------------------------VHSNSRPFFKTRSGQSTLSANSRGQLPSQASR QSHQESGSRYDDSQN-------------------------------------Y------- --------------------------------ST-------------------------- ---------------ELEDQDVRIHTHSTH------------------------------ --------------------------------------HKD------------------- -----------------------------------------------GL----------- ---------------------SPTSSLSKQEQI--------------------------- ------GAQSRD---ADEKSQSRH------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------TSSPSSRDSGSSLPAGR-----SSSSR---- -----------ETYTKPTLPFV-----------------------HSRARAP-------- -------------------------------------------------------SRTTS Q-VEKKDSLYQSTP--SKIEPPSKSPLSSSL----------------------------- ----------KSHQSVSNDDDEDDDDNREYTRRNKEE---------------DSISSSVS KWPPSS----SGKYINR-NVGKDK---------EKSVSSLF------------------- --------------------------------------------------------PPRV ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------------R SNE--------------------------------------------------------- ----------------------EENST--------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------PL-------------------------------------- -------------------KRPILPP---------------------------------- ------------------------------------------------------------ -----------------------------LG------------------ST--PRTSQIP --------NAPSKFLPRSH----------------------------DTQSPISSTPLHT ------------------------------------------------------------ ---------------TTHAPLTY------------------------------------- ----SST-T--------------------------------------------------- ------------------------------PML----------SLRQRMLN--------- ----S----------RLRNSP-----SRY-------------PA---------------- ------------------------------------------------------------ ---------------------------RPSY------R------P--------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------GNNGRPNI----------- --DGK---VLPGSNGQLSGQRIINGPQGTKWIVDLDRGLVLNSEGRHLQDSHGNPLRVKL GGDGRTIVDMGGTPVVSPDGLPLFGQGRHGKPLASAQDKPVLSLGGKPLMGLE--VIKTT KTPT-TT----------------------------------------------------- ------------------------------------------------------------ ---------TTH-------PTTTKA------------TTTTTTTTTTTTTTTTTTT--PA -----TTPEPTTPEP-------------TI------------------------------ -PVPTCPPGTLEQRDDYGNLLM-GADGMPECS--------------------------P- ------------------------EEDNFSGLETD--------TAIPTEEAYVVYDE--- ---------------------D--------YE-FE-TTL-------P-----P---T--- -------TTKSS-------------------------------------------TTT-I AVPK-----------VISPEGS----------------------I--------------- -----SSFPEEEFDLAGKKRFV--------------------------APYVTYLNKDPL APCSLTEALDHFQVDSLDEIIPSD--LTKSDSPPQHAPRNITVVAVEGCHSFVIVDWDKS TQGDVVTGYLVYSASYEDFIRNKWSAQSSGVTHLPIENLKPNT----------------- -------------RYYFKVQAKNPYGYGPISPSVSFVTESDNPLLVVRPPG--------- ------GEPIWIPFAFKRDPSYTDCHGRQYVKRTWYRKFVGVVLCNSLRYKIYLSDNL-K -DTFYSIGDSWGRGEDHCQFVDSHLDGRTGPQSYVEALPTVQGYYRQYRQEPVGFGRIGF GTPYYYVGWYECGVSIPGKW---------------------------------------- ------------------------------------------------------ >ENSSHAP00000014439 ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------VDSYAVCI ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------VDHPL------- -----------------------KPRNVRLQSTKRGLKVTWEPPKEATTRPV----EYYN ------------------------------------------------------I-AYGK S-----------------------------------------------LK---------- -----------NLSYIKVNGATHSFLIEDV--------------------------EPGV VYFVLVTSENYS--------GVSRPVYRAESLL--------------------------- -------------------------------------------------------GG--- ---------------------------------EWIKIDGFDIKGPES------------ ------------------LNETMT------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------EKEVPNKPLRVRVRSS-------------------------------------- -----------------DDKLSVQWKAPRA-SGIKS-------PR-RSQGFLLGYG---- -ESGRKMNY------------VPLTRDERAHEIKKL---ASESV---------------- ---------YVVSLQSMN-----------------SQGQSQPVYRAALTKRKTEEE---- ---DELEEPEDISVRVMSSQSVLVAWLDPLLE-KQKRAV--AS-RQYTVRYREKGESARW DYKQVSARRTLIENLIPDTMYEFAVRISQGERDGKWSTSVFQRTPESAPTTAPENLDVRP VKGKQTAVTASWEALPETEGRVKEYILSYAPALKPFGAKSLTYPGETTSAIVDGLQPGER YLFKIRAANRRGQGPQSKAFIVAMPT-----------T-VTSEPNTHQRMNIKDKLDPKK PE----------------------------------------------PSQKV----P-- -------SSKHIH-S--------------------------------------------- --------SLSPKGRDVKT--PDLKNKLLSNSEVLNKPQLPPKKRTEI-GSDLQS----T EVTD--------DDLDNQ---PTSQSK-------------VQD----------------- -----------NRRNVRPSLPSRSFHSVLGPGRTPVRTRIPTLPQKTNTD---------- -----------------------------------------------------------S ---------------------------HDSSSSSQDSQSASTSPSSSSSH---DS----- -------------RIHNSHY----------------------------------P----- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------SSRVTSVNPSHENINNDPV--VDNDDKNERHIKDPLHSK--------- ------------------------------------------------------------ -------------------------------YPLSGKPV-----SKTAERSRLTVPSNQE ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------SVTNQEKSLIHGERKSHLPAHT NAPSENWEEKSSFLV--------------------------------------------- ------------------------------PATRTSS----------------------- ------------------------------------------------------------ ----------------------------------------HGGTPRALPTRFHSGS---- ------------------------------------------------------------ -------------------------------------------HPRVLKNDQEARAINSA MPSQST----ARHSPSHSHLSSMKQTPDERNG---------------------------- -------------------------------------------------------SDDDG NEDYDVGDKKRQTDSTSPTFRS---------RLAA------------------------- ----------GQPISGNLNFPRRRPFSPSSRYPNRVIGSQGIRSQPSSS---PQS---TT SSRVH------------------------------------------------------- ------------------------SHHIS------------------------------- DPRIGSDVDRDEKER--------------------EEDDEERPLP-------------ST ------------------------------------------------------------ ---------------------IVNDY-L------------SS----------------SS S------------------RQPVSSNPDHMRRIPQRVSSVHRKMPLTENA---------- -------------------------------NS--------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------PLTSQSSL-TESHSQGNSPS---------------------------- ---------------------FSNKLHTQDGHRNTGIEGVRARV------RPST------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------RSQH----------------- ------------------------------------------------------------ ---------------------------------------------------QSG-SSVPT RV---------------------------------------------------------- ----------------MNVQDSRSAAVSSERHPSSH------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------VSTSKHQLHAHQGKEVENPLSKSKQLLSIPRNSYSPS QD--------------------------VHSNSRPSFKTRAGQSTLSANSRGQVSPQVSR QSHQESENRYDDSLN-------------------------------------Y------- --------------------------------ST-------------------------- ---------------ELEDQDVKINTQSTH------------------------------ --------------------------------------HKD------------------- -----------------------------------------------EL----------- ---------------------SPTSSLSKQQQI--------------------------- ------GTQSGN---ADEKPQSRH------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------TSSSSSRGSSSSLPAGR-------------- ----------------------------------------------SRARVP-------- -------------------------------------------------------GRTVS G-VEKKDSLYQSTP--SKIEPPSKNPLSSSP----------------------------- ----------KSHQSVSNDDDEDDD--REYARRDKQE---------------DSISSSVS KWPPSS----GGKYINR-NI--DK---------DKSVSS--------------------- ----------------------------------------------------------RV ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------------R SNE--------------------------------------------------------- ----------------------EEDSA--------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------PL-------------------------------------- -------------------KRPISPP---------------------------------- ------------------------------------------------------------ -----------------------------LG------------------SP--SRTSQIP --------NAPSKFLPRSR----------------------------NTQGLISSTPLYT ------------------------------------------------------------ ---------------TTHAPLTY------------------------------------- ----SST-T--------------------------------------------------- ------------------------------PML----------SLRQRMLN--------- ----S----------RLRNPP-----SRY-------------PA---------------- ------------------------------------------------------------ ---------------------------RPPY------R------P--------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------GNNGRPNV----------- --DGK---VLPGSNGQLSGQRIINGPQGTKWVVDLDRGLVLNSEGRYLQDSHGNPLRVKI GGDGRTIVDMGGTPVVSPDGLPLFGQGRHGKPLASAQDKPVLSLGGKPLMGLE--VIKTT KTPT-TT----------------------------------------------------- ------------------------------------------------------------ --------STTR-------P------------------TTTTTMATTTTTTTPATT--TT TTPEPTTPEPTTPEP-------------TI------------------------------ -PVPTCPPGTIEQQDDYGNLVM-GADGMPQCY--------------------------P- ------------------------EEDNFSGLETD--------TAIPTEEAYVVYDE--- ---------------------D--------YE-FE-TTL-------P-----P---T--- -------TTTSS-------------------------------------------TTT-M AVPK-----------IISPEGS----------------------I--------------- -----SSFPEEEFDLAGKKRFV--------------------------APYVTYLNKDPL APCSLTEALDHFQVESLDEIIPND--LKKNELPPQHAPRNITVVAVEGCHSFVIVDWDKS TQGDVVTGYLVYSASYEDFIRNKWSTQTSGVTHLPIENLKPNT----------------- -------------RYYFKVQAKNPYGYGPMSPSVSFVTESDNPLLVVRPPG--------- ------GEPIWIPFTFKRDPSYTECHGRQYVKRTWYRKFVGVVLCNSLRYKIYLSDNL-K -DTFYSIGDSWGRGEDHCQFVDSHLDGRTGPQSYVEALPTVQGYHRQYRQEPVEFGRIGF GTPYYYVGWYECGVSIPGKW---------------------------------------- ------------------------------------------------------ >ENSMODP00000009358 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------------MALVGRASRL PGLP------------------LLLLAALVYFAS-SE-AP-------------------- ------------------------------------------------VDHPL------- -----------------------KPRNVRLQSTKRGLKVTWEPPKEATTRPV----EFYN ------------------------------------------------------I-AYGK S-----------------------------------------------LK---------- -----------NLSYIKVNGATHSFLIEDV--------------------------EPGV VYFVLVTSENYN--------GVSRPVYRAESPL--------------------------- -------------------------------------------------------GG--- ---------------------------------EWIKIDGFSIKGPEP------------ ------------------LNETMT------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------EKEVPNKPMRVRVRPS-------------------------------------- -----------------DDKLSVQWKAPRA-SGIKS-------PR-RSQGFLLGYG---- -ESGRKMNY------------VPLTRDERAHEIKKL---ASESV---------------- ---------YVVSLQSMN-----------------SQGQSQPVYRAALTKRKIEEE---- ---DELEEPEDISVRVMSSQSVLVAWVDPVLE-KQKRTV--AS-RQYTVRYREKGESARW DYKQISGRRTLIEDLIPDTMYEFAVRISQGERDGKWSTSVFQRTPESAPTTAPENLDVRP VKGKQTAVTASWDALPETEGRVKEYILSYAPALKPFGAKSLTYPGETTSAIVDGLQPGER YLFKIRAANRRGQGPQSKAFIVAMPT-----------T-VTNDPNAHQRMNMEDKLDPKK PE----------------------------------------------PSQKIP-SPP-- -------SSKHIH-S--------------------------------------------- --------SLSPKGKDTKTPLPDLKNKILTNSEVLSKSQLPSKKRAET-GSDLQS----T EVTD--------DDLDSHSESPTSQSK-------------TQG----------------- -----------SRRNGRPPLPSGSFPSVLGPGKTPMRARIPLLTRKTNLD---------- -----------------------------------------------------------S ---------------------------HDSSSSSQNSQTASTSPSSSSFQV-SDD----- --------ETRHQRMRNSDY----------------------------------P----- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------SSRVTSVNPSHENTSNDPVVDDDGDEKKEGLTKDLPHSK--------- ------------------------------------------------------------ -------------------------------YPSSGKPV-----SNTMERSRLTIPSNRQ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------LVTQREKSPTRGEGKSHLPAHT NAPSENWEEKSSFLV--------------------------------------------- ------------------------------PATRTSS----------------------- ------------------------------------------------------------ ----------------------------------------HGGTSRTLPTRFHPGS---- ------------------------------------------------------------ -------------------------------------------HSRVLKNDQEARAINSA LPSQSTVSSPAHHTPSHSHLPSMKQTPRERIG---------------------------- -------------------------------------------------------SDDDG NEDHDVEDKKK-TDSTSSTFHS---------RLAA------------------------- ----------GQPVSGNLNFPRRRTFSSSSRYPNRAGSSQSLRSHSSSS---PQS---TT SSRVH------------------------------------------------------- ------------------------SQNIA------------------------------- --------DKDEEER--------------------EEEDEERPLT-------------ST ------------------------------------------------------------ ---------------------IVNDY-L------------P-----------------SS S------------------RQPTSQSSDHIRRIPQRVSSAHRKVPLTENA---------- -------------------------------KS--------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------PVTSQSSS-SDARSQDNSPS---------------------------- ---------------------FPNKLHPQDTHQNTGTEGIPARV------RPST------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------RSQH----------------- ------------------------------------------------------------ ---------------------------------------------------PSG-SSAST RV---------------------------------------------------------- ----------------TNVQNSRSVAVSSEKHPSSH------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------LSTSKEQLHDYQDKEVENPLSKSKQ-------SYSSS QDS-------------------------VHSSSSPSFKTRAGQSTFSTNSRRQLSPQGSR QTHRESESRHDDSQN-------------------------------------Y------- --------------------------------ST-------------------------- ---------------ELEDQDARINTHSTH------------------------------ --------------------------------------HKDI------------------ --------------------------------------------SSSGS----------- ---------------------SSTSSLSKQQQI--------------------------- ------GVKSGN---ADEKSQSRH------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------TSLPSSRGSGSSLPGSR-----SSSNR---- -----------ETSAKTTLPFL-----------------------HSRARVP-------- -------------------------------------------------------SRTTS Q-VEKKDSLYQSTP--SKIEPPSKSPLSSSL----------------------------- ----------KSHQSVSNDDDDDDE--REYTRRDKEE---------------DSISSSVS KWPSSS----SGKYANR-NIGKDK---------EKPVNPLF------------------- --------------------------------------------------------PHRV ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------------R SNE--------------------------------------------------------- ----------------------EDNST--------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------PL-------------------------------------- -------------------KRPIPPS---------------------------------- ------------------------------------------------------------ -----------------------------LG------------------ST--SRASQIP --------NAPSKFLPRSR----------------------------STQSPISTTSLHT ------------------------------------------------------------ ---------------TTHAPLTY------------------------------------- ----SST-T--------------------------------------------------- ------------------------------PML----------SLRQRMLN--------- ----S----------RIRNPP-----SRY-------------PV---------------- ------------------------------------------------------------ ---------------------------RPPY------R------P--------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------GNNGRPNV----------- --DGK---VLPGSNGQLSGQRIINGPQGTKWVVDLDRGLVLNAEGRYLQDSHGNPLRVKL GGDGRTIVDMGGTPVVSPDGLPLFGQGRHGKPLASAQDRPVLSLGGKPLMGLE--VIKTT RTPT-TT----------------------------------------------------- ------------------------------------------------------------ --------STNR-------PTTTMS--------TTSRSTTTTTIATTTT----------- -----TTPEPTTPEP-------------TI------------------------------ -PVPTCPPGTFEQHDDDGNLIM-GADGMPECY--------------------------S- ------------------------EEDDFSGLETD--------TAIPTEEAYVVYDE--- ---------------------D--------YE-FE-TTL-------P-----P---T--- -------TTKSS-------------------------------------------TTT-M SVPK-----------VISPEGS----------------------I--------------- -----SSFPEEEFDLAGKKRFV--------------------------APYVTYLNKDPL APCSLTEALDHFQVESLDEIIPND--LTKNDLPPQHAPRNITVVAVEGCHSFVIVDWDKS TQGDVVTGYLVYSASYEDFIRNKWSTQSSGVTHLPIENLKPNT----------------- -------------RYYFKVQAKNPYGYGPVSPSVSFVTESDNPLLVVRPPG--------- ------GEPIWIPFAFKRDPSYTDCHGRQYVKRTWYRKFVGVVLCNSLRYKIYLSDNL-K -DTFYSIGDSWGRGEDHCQFVDSHLDGRTGPQSYVEALPTVQGYHRQYRQEPVEFGRIGF GTPYYYVGWYECGVSIPGKW---------------------------------------- ------------------------------------------------------ >ENSMLUP00000021493 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------------SS-------- ---PAA------------------------------------------RGGQQLLAGRLC CGHRLP----------------------------------LDSCAVCIADHPL------- -----------------------KPRHVKLLSTKMGLKVTWDPPKDATSRPV----EHYN ------------------------------------------------------I-AYGK S-----------------------------------------------LK---------- -----------SLKYIKVNAETQSFLIEDV------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------EKEVPNKPLRVRVRSS-------------------------------------- -----------------DNRLSVAWKAPRL-SGAKS-------PR-RSRGFLLGYG---- -ESGRKMNY------------VPLTRDERTHEIKKL---ASESV---------------- ---------YVVSLQSLN-----------------SRGQSQPVYRAALTKRKISEE---- ---EELDVPEDISVRVMSSQSVLVAWVDPVVE-KQKKVV--AS-RQYTVRYREKGELARW DYRQGSNRRVLIEGLLPDTMYEFAVRISQGDRDGKWSTSVFQRTPESAPTTAPENLKVWP VNGKTTAVTVAWDALPETEGKVKEYILSYAPALKPFGAKSLTFPGETTSALVDGLQPGER YLFKIRAANRRGSGPHSKAFIVAMPT-----------S-RTSEPDARQKTGAMENWKQET AQ----------------------------------------------PASP-PRAAA-- -------PSKHAH-L--------------------------------------------- --------PVSPQGRHAKHP-PDLKNKIPANGGVPRKP---------------QA----A ELTD-------AEELDPQGDPPTSPSE-------------TQD----------------- -----------QQRQPRP--PGRPVHPGLA-GRTPGRVRAPVLPRQEGVDK-PGSSPPSH --------PR-GA----------------------------------------------S P------------WVPHTPTAGSSRR---------------------------------- ------------------------------------------------------P----- ------------------------------------------------------------ ----------------------------AHLPSSSVDN---------------------- ----------------------DSLDGEEAEPATGSLDPKD------------------- ------------------------------------------------------------ ----------ASSERLRPE----------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------------S-APA----- -RPALGPGRHPASSA-RPRGPALQGARPALPA-------------------RRAP----- --------H-------------------------SEAA---------------------- ---------------------------------------PHGGASRLLPTEPQPGP---- -------PLPRGGKDGHDALAARSH---------------APSRPTTS------------ -----------SPVSSR------------------------------------------- ------------------------------------------------------------ VAPRPQAPRTV------------------------------------------------- DGDSDAAD---------------------------------------------------- ------------AVPGHVSPHRNKPFAAHSRYPNR------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------P------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------G-------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------Y------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------RR------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------R---------------------------------- ------------------------------------------------------------ ----------------P------------------------------------------- ---------------------------------------------------PTTCLQGEA KEMGKKDEQFKKLNLAKSDVSVIVDVEGEEEEGEKPRVFERREGENPCLALFIK------ ------------TP---------------------------------------------- -------------------------LLR-------------------------------- --------PRGSKYADR------------------------------------------- -------STR---------GDGLCQRACCPPRWL-------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------P-PG------------------------------- ------------------------------------------------------------ ------------------------------G------------------EP--------- ----------------HSP----------------------------AAAS--------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------SCRQR------------ ------------------------------PQSLTPPAQTP-PS---------------- ------------------------------------------------------------ ---------------------------QPQH------G------QRPGGHAGAAPVHDAR PSGLRLHDAHAVAAAAHDALAVPEPLVPRAGPALLQTSTVRSFPASGMLRHRHAAAALQI PSGGVSRVSPGFQLRRLG----------------------------------------LR GLC--------------------------------------------------------- ------------------------------------------------------------ ----GWP----------------------------------------------------- ------------------------------------------------------------ -------RSDSQEGCGSPNPALSPAALAAALPHSPLTTRPALHLTSGSIKMDCLKPKTPV TNRTQMPLYKGAQAFDPMEGLDHRVLPAELRGPAAEKWREMERKGRRQEQADTATER--- -AASWALYFLSEQVLPKRPAELSKPSQPRANPAEESRTAASTFQRQFSPTLPRSVQLPTG NIKLQRLRPL----------IFIWIIYAGGIDQVLLPVSCAGYNGRPSV----------- --EGR---GLPGTNGKPSGQRIINGPQGTKWVVDLDRGLVLNAEGRYLQDSHGNPLRVKL GGDGRTIVDLRGTPVVSPDGLPLFGQGRHGKPLASAHDKPILSLGGKPLVGLE--VVKTT TRAA-AT-----T------------TTTTTTER--------P--TTTPRPT-----TANL --RP---RTT-----TRRTTTTTT---------------------------------RRT TTTRPTT-TTLR-------PTTTIR--------TTTP----------------TTT--TT ----------TTPEP-------------TT------------------------------ -AVPTCPPGTLERHDEDGNLVT-GSSGAPECI--------------------------P- ------------------------EEDDFSGLETD--------TATSTEEAYVVYDA--- ---------------------D--------YE-LE-TSR-------P-----P---A--- -------STRPS-------------------------------------------TMA-- ATPA-----------VIPAEGT----------------------I--------------- -----SSFPEEEFDLAGKKRFV--------------------------APYVTYLSKDLS APCSLTDALDHFQVESLDEIIPTD--MRKNDLPPQHAPRNITIVAMEGCHSFVIVDWDKA TPGDVVTGYLVYSASYEDFIRNKWSTQASTVTHLPIENLKPNT----------------- -------------SFRFKVQAKNPQGYGPISPSVSFVTESDNPLLVVRPPG--------- ------GEPIWIPFAFKHNPDYTDCHGRQYVKRTWYRKFVGVILCNSLRYKIYLSDNLKK -DTFYSIGDSWGRGEDHCQFVDSHLDGRTGPHSYIEALPSIQGYYRQYRQEPVRFGNIGF GTPYYYVGWYECGVSIPGKW---------------------------------------- ------------------------------------------------------ >ENSDNOP00000021898 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------VDSCTVYIVDHPL------- -----------------------KPRNVKLLSTKMGLKVTWDPPKDATSRPV----EYYN ------------------------------------------------------I-AYGK S-----------------------------------------------LK---------- -----------SLSYSKVNAETHSFRIEDV--------------------------EPGV VYFVLVTAENLS--------GVSRPVYRAERPP--------------------------- -------------------------------------------------------GG--- ---------------------------------EWIQIDGLPVKGPGP------------ ------------------SHEPVT------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------EKEVPNKPLRVRVRSS-------------------------------------- -----------------DDKLSVQWKAPRL-SGAKS-------PR-RSRGFLLGYG---- -ESGRKMNY------------VPLTRDERTHEIKKL---ASESV---------------- ---------YVVSLQSIN-----------------SQGQSQPVYRAALTKRKISEE---- ---EELDVPEDISVRVMSSQSVLVTWVDPVLE-KQKKVV--AS-RQYTVRYREKGESARW DFKQVSHRRVLVETLLPDTMYEFAVRISQGDRDGKWSTSVFQRTPESAPTMAPENLNVWP VSGKPTSVIASWDALPETEGKVKEYVLSYAPALKPFGAKSLSYPGETTSARVDGLQPGER YLFKIRAANRRGQGPQSKAFIVATPA-----------A-STSEPKVQPGADSEDHSKPDK PK-------------------------------------------------PSPKVPA-- -------SS--------------------------------------------------- --------PVSPRNRNSKNHLADWKNKILANGGMPRRPQLSPKRTEAL---DLQS----T E-TS-------EEEQDSHADPPAPPSG-------------TQE----------------- -----------PRRPGRPP-PPRSFPSGLVPGRTPSRAWTPELPRR-------------- -----------GPAQPGPWLPSRAPAEQ-------------------------------S P----------------------------------------------------------- --------------------------------------------------STAAP----- ---------------------------------------------------------SAH G------------HSDR-------------------DN---------------------- ----------------------ESTGQDDGEPRAG----------D-------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------ALG--------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------PGQP-------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------GNGRGLRPQPTTA---P------- ------------------------------------------------------------ ------------------------------------------------------------ --------------GGLSKASSVPTSELDSAVGGDEEEEAEKPLP-------------AT ------------------------------------------------------------ ---------------------VTNDV-L------------P-----------------ST S------------------RQP-SGGLDHLSRILQRGPAVPRKEPLVGSP---------- -------------------------------KVTAP-----------------SSAP--- ----------------------AAGHTPG-----------------QVPPATAQAARQGA ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --TPGRRPSPARP----------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------RP---------------------RP---------------------GASAL- ------------------------------------------------------------ ---------------G--------------------------------------P----- ---------------------------PH------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------GHQPAA PRSKLEHPVWQQSPRAPVPSQPDAPTQKRESHAH-------------------------- -D---------------------------------------------------------- -------------------------------------GRVGSREGSPDGE---------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------------------PPS A----------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------R---------------------------------- ------------------------------------------------------------ ----------------P--------------------------------------RAAPP ----PPGLEKKD--------------------------------------VP-------- ----------------------------------------------PA------------ -------------PR-AKAAPPAKRPLAG------------------------------- ----------KSAQSVAPKDDE-----R---------------AFAKAGKD-DALSGAVP KGP--------------------------------------------------------- --FASKDAARS------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------A------------------AP--PRAAPVP PGPPP-----------GSP----------------------------AAPA--------- ------------------------------------------------------------ ---------------GTRAPVLH------------------------------------- ----TST-T--------------------------------------------------- ------------------------------PML----------SLRQRMMQ--------- ----S----------RFRNPL-----SRQ-------------PA---------------- ------------------------------------------------------------ ---------------------------RPLP------G------P--------------- ------------------------------------------------------------ -----------------GNVRFGSQKMSLNLFSKVARWRPKPFLGGAVLSFTLETEVTCR GLCCCPRRLGAEAGLQWLAEARWPAVAERPCWALGSNSTALAPHLPLGHFQFLHIGSSSP KRAPAEARSGSGLRLFVTAPEQACAWDAQGGQRAQARPLSLHTEPSAAFLRGNLRKKPLK MNILAWPGASGALGGVCKRVSLWRAAIVAQVKPWNKPHVELSSHSTLGPPAKQLARNSSR GREGAGQGDRGTRSAEGTAVSWLEPRLSLSAQASQAAADADSSSAEKPLVRFHPPVIQRL KEQLQLLR---------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------SYNGRPTV----------- --DGK---VPPGSDGKQNGRRVINGPQGTKWVVDLSRGLVLNAEGRYLQDSHGNPLRVKL GGDGQTIVDLGGTPVVSPDGIPLFGQGRHGQPLASAQDKPVLSLGGKPLVGLE--VVRTT SRPP-ATPRAPATPRP---------TTTTTTTP------EPT--TTHPRPT-----T--- --RPRPTTTT----TSRRP--TTTAPRRPPA----------------------------- ---RRMP-SAAR-------PAGTIR--------TTTR----------------PTT--TT ----------TTPEP-------------TT------------------------------ -PMPTCPAGTLEQHDGDGNLIL-GSNGTPECY--------------------------A- ------------------------EEDELSGLETG--------TATATEAAYVVYDD--- ---------------------D--------YE-FE-TSR-------A-----P---A--- -------TTKPS-------------------------------------------TTA-- AAPV-----------VLSPEGS----------------------I--------------- -----SSFPEEEFDLAGRKRFV--------------------------APYVTYLSKDPT APCSLTDALDHFQVDSLAEIIPND--LRSSSLPPQHAPRNITVVAMEGCHSFVIVDWDKA APGDVVTGYLVYSASYEDLIRNKWSTQASSVTHLPIENLKPNT----------------- -------------RYYFKVQAQNPHGYGPVSPSVSFVTESDNPLLVVRPPG--------- ------GEPIWIPFSFKHDPSYTDCHGRQYVKRTWYRKFVGVVLCNSLRYKIYLSDNL-K -DTFYSIGDSWGRGEDHCQFVDSHLDGRTGPQSYIEALPAIQGYHRQYRQEPVSFGRIGF GTPYYYVGWYECGVTIPGKW---------------------------------------- ------------------------------------------------------