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-----------------------------------------xxx------ -------------------------------------------------- ---------------------------------x---------------- ----------xx-------------------------------------- -xxxxxxx------------------------------------------ -------------------------------------------------- ----------------------xxxxx----------------------- --------------------------xxxxxxx----------------- -------xLDHPL------------------------------KPRRVKL LSSKLGLKVTWEPPRDAASRPV----EHYN-------------------- ----------------------------------I-AYGKS--------- --------------------------------------LK---------- -----------SLKYVKVNAEASSFLTEDV-------------------- ------EPGVVYFVLVTAENHS--------GVSRPVYRAESLP------- -------------------------------------------------- -------------------------GG----------------------- -------------EWIKIDGFPIKGPGA---------------------- --------FNETIT------------------------------------ -------------------------------------------------- -------------------------------------------------- --------------------------EKEVPNKPLRVRVRSS-------- -----------------------------------------------DDR LSVAWKAPRL-SGAKS-------PR-RSRGFLLGYG-----ESGRKMNY- -----------VPLTRDERSHEIKKL---ASESV---------------- ---------YVVSLQSVN-----------------SQGQSQPVYRAALTK RKISEE-------DELDVPRDISVRVMSSQSVLVAWVDPAVE-KQKxxx- -AS-RQYTVRYREKGESARWDYKQTANRRALIESLIPDTVYEFAVRISQG ERDGKWSTSVFQRTPESAPTTAPENLRVWPVNGKPTVVTASWDALPETEG KVKEYILSYAPALKPFGAKSLTYPRGTTSALVDGLQPGERYLFKIRAANR RGPGPPSKAFIVAMPA-----------A-SAAERDAAQ--STVENWKPQS Px----------------------------------------------xx xxxPQTPA---------PSGHTx-x------------------------- ----------------------------PASPRGSKAKDLLLDLKNKILA NGGLLRKPQLRPRKTGEP---DPQS----TEVTQ-------EEEPDSLED PRTTPLQ-------------TQE--------------------------- -HRQTLRP--LSRPGHPALVPGRTPARARVPGPPRQEGVHR-RG------ -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ------xxxxxxxxxxxxxxxxxxx------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------x------------------------ -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- xxxxxxxx-----------------------xxxxxx------------- 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-------------xxxTxxxxxxxxx-xxxxxxLRSPQTRPVSNGHRLxx xxx----------------------------------------------- -------------------------------------------------- -PAS---------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -----xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx--- -------------------------------------------------- -------------------------xxxx--------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- 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-------------------------------------------------- --------------------------xxxx-------------------- -------------------------------------------------- -------------------xxx---------------------------- -----------------------------------xxxx----------x xxxP--GQKEALSKRPLxx------------------------------- ----------KSQQSVSAExx-------------xxx-xxxxxxxxxxxx x-xPLPxSVSKWPSxxS-PRGGKYTKD----------------------- -----------------------------xx------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ----xx-x------------------------------------------ -------------------------------------------------- ------------------------------x------------------S T--xxxPxxxxxxxP-----------xxx--------------------- -------xxxxx-------xxx---------------------------- -xxx------------------------------------------xRAP PDF-----------------------------------------xxT-x- -------------------------------------------------- ------------------------------xML----------SLRQRxx x------------------------RFRTPG-----SRQ----------- --PP---------------------------------------------- -------------------------------------------------- -------RSLH------T------Q------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ---------------------GYNGRPNA-------------EGR---VL PGSNGKPNGQRIINGPQGTKWVVDLDRGLVLNAEGRHLQDSHGNPLRVKL GGDGRTIVDLSGTPVVSPDGLPLFGQGRHGKPLASAQDKPILSLGGKPLV GLE--VVKTTTLPP-TT-----TRxx---------xxxxxxxx------- ----xxxxxxx-----x-----------xx-----xxxx--xxxx----- --------------------------xxxxxxxRxxx-xxxx-------x xxxxxxxxxxxxxxxxx-----------------xx--xx---------- xxxxx-------------xx------------------------------ -SPPTCPPGTLEQHDDDGNLIM-GSNGIPECY------------------ --------P-------------------------EEDDFSGLETD----- ---TxxPTEEAYVVYDE-------xxxxxxxxx----------------- ----------------------x---x----------------xxxxxxx xxxxxxxxxxxxxxxxxxxxxxxxxxxxx--------------------- -------------------------------------------------- ------------------------------------------------AP YVTYLSKDPAAPCSLTDALDHFQVESLDEIIPHD--LKKNDLPPQHVPRN ITVVAMEGCHSFVIVDWDKASPGDVVTGYLVYSASYEDFIRNKWSTQASS VTHLPIENLKPNT------------------------------RYYFKVQ AKNPHGYGPISPSVSFVTESDNPLLVVRPPG---------------GEPI WIPFAFKHDPSYTDCQGRQYVKRTWYRKFVGVVLCNSLRYKIYLSDNL-K -DTFYSIGDSWGRGEDHCQFVDSHLDGRTGPQSYVEALPAIQGYYRQYRQ EPVSFGQIGFGTPYYYVGWYECGVSIPGKW-------------------- -------------------------------------------------- ------------------------ >ENSMOCP00000009284 -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ----------------------------------------xx-------- ---xxxxx---xxxx-xxxxx-xxxxxxxxPxxxxxx-xx---------- -------------------------------------------------- --------ADHPL------------------------------KPRHVRL LSTKVGLKVAWDPPKDATSRPV----EHYN-------------------- ----------------------------------I-AYGKS--------- --------------------------------------LK---------- -----------SLKYIKVNAETNSFLIEDV-------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- --------------------------xKEVPNKPVRMRVRAS-------- -----------------------------------------------DDR LSVAWKAPRL-SGAKS-------PR-RSRGFLLGYG-----ESGRKMNY- -----------VPLTRDERSHEIKKL---ASESV---------------- ---------YVVSLQSTN-----------------SQGQSQPVYRAALTK RKNSED-------SELDVPEDISVRVMSSQSVLVAWVDPLVE-KQKxxx- -AS-RQYTVRYREKGESARWDYKQVSNRRVLVDNLIPDTVYEFAVRISQG ERDGKWSASIFQRTPESAPTTAPENLNVWPVSGKPTVVTVSWDALPETEG KVKEYILSYAPALKPFGAKSLTFSGHTTSALVDGLQPGERYLFKIRATNR RGPGPHSKAFIVTIPT-----------T-SSPEASVHQ--DGRNIRKPEK Px----------------------------------------------xx xxxPKTAA---------SSEHT---------------------------- -------------------------------PPAKNAMDDLLDLKNKILA NGVPPRKTQLHS-KMGEL---DPQT----TDVNG-------EEELDSLED PRPSRVE-------------TLD--------------------------- -RRRPLRV--PSRSGHWVPAPGRTPARTGLPVLPRKEGMDR-RGTSxVPH --------PH---------------------------------------x xxxxxxxxxx-------------xx------------------------- ---------------------------------------xxxxxx----- -------------------------------------------------- -------------------------------------------------- -------------------------xxN---------------------- ----------------------DSMNQNEDDQE---------xxxx---- -------------------------------------------------- -------------------------------------xx----------- ---------------------------------------------xxxxx x-xxxx-------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -----------xxxxxxxx-----------------PRHHVASDxxxxxx xxxxxxxx------xxxxxxxxxxxxx----------------------- ----------------------------xxxxxxxxx------------- ------xxx---------------------------HGPLHRGSSR---- -Pxxxx-----------Qxxxxxxxxxxx--------------------- -xxxxxxxxxxxxxxxxxxxxxxxxxx----------------------- -------------------------------------------------- -------------------------------------------------- ---------------------------------------------xxxxx xxxxxAGDTRRQAEVTAQxQQT---------x------------------ ----------------------PALGxxxxxRNKPFSAHSRNPNRFPRFR GLxxxPxxx---xxx---TSTPKVL------------------------- -------------------------------------------------- xxxxxxxAx-------------------------------xxx--xNVxG x--------------------------xxDEEPxx-------------xx -------------------------------------------------- -------------------------------VVNNR-T------------ P-----------------SSS------------------RHPASGGWDTL RRGPQRGTxxxxKDPIPxxx------------------------------ -----------xxx------------------------------------ ------------------------------------------------xx --------------------------xxxxxxx----------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------xxxSxxxxxxxxx-xxxxx----xQTSPGSTSRQLxx xxx----------------------------------------------- -------------------------------------------------- -PAP---------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------Rxxx--------------------------- -------------------------------------------------- -------------------------------------------------- -xxx-xxVxxRMTxxxxxxxx----------------------------- -----xxxxxxx-------------------------------------- ---------------------------------------------xxxxx x------------------------------------------------- -------------------------------------------------- ---------------------------xxx-------------------- ---------xxx--------------------xxxxxxxxxxx------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -x------------------------------------------------ --------------------xxxxx------------------------- -----------------------------------------------xxx xxxx-----------------------------------------xxxxx xxxxxxxxxx---------------------------------------- ----------------------------xxx------------------- -------------------------------------------------- --------------------------------xxxxxxxxxxx------- --------------------------xxxxxx---xxxxxxxxx------ -------------------------------------------------- -------------------------------------------------- --------------------------------------xxxx-------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -----------xxxxx---------------------------------- -------------------------------------------------- --------------------------x----------------------- -------------------------------------------xx----- --------------xxxRAQVP---------------------------- -----------------------------------GRAG----------x xxxP--VKKISPSKGPLxx------------------------------- ----------ESLQSVFTExx-------------xxx-xxxxxxxxx-xx x-xxxxx--SKWPSxxS-HRGNKYADR-xxxxxxxxx------------- ---------------------------------------x---------- --------xxxxxxxxx--------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ----------------------------------------PG-------- -------------------------------------------------x x----x-x------------------------------------------ -------------------------------------------------- ------------------------------x------------------x x--xxxTHxxxxxxP-----------xxx--------------------- -------xxxx--------------------------------------- ---xxxxxxxWPR-------------------------------YxxHAP PSY-----------------------------------------xxT-x- -------------------------------------------------- ------------------------------xML----------SLRQRxx x------------------------RFRTPV-----SRH----------- --Px---------------------------------------------- -------------------------------------------------- -------RPVL------A------Q------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ---------------------GYNGRPNV-------------EEN---IP PGSVGKPNRQKIINGPQGTKWVVDLDRGLVFNAEGRYLQDSLGNPLRVRL GGDGRTIVDLGGTPMVSPDGLPLFGQGRHGKPLASAQDKPILSLGGKPLV GLE--VIRTTTHPP-TT-----TMxx---------xxxxxxxx------- -x--xxxxxxxxx---xx----xx----xx-----xxxxxxTTT------ ---------------------------------Rxxx-xxxx-------x xxxxx--------xxxx----------------xxx--xx---------- xxxxx-------------xx------------------------------ -LSPTCPPGTVEQQDEAGNLIM-GANGIPECY------------------ --------P-------------------------EEDDFSGLDTD----- ---TxxPTDVGYAVYDD------------------------D-------- YG-FE-TTR-------P-----P---x----------xxxxS-------- -----------------------------------TTA--Axxx------ -----xIPEQGT----------------------V--------------- -----SSFPEEEFDLAGKKRFV--------------------------AP YVTYLSKDPSAPCSLTDALDHFQVESLDELIPND--LTKNELPPQHAPRN ITVVAMEGCHSFVIVDWNKAIPGDVVTGYLVYSASYEDFIRNKWSTQTSS VTHLPIENLKPNT------------------------------RYYFKVQ AKNPHGYGPVSPSVSF---------------xxxxxxxxxxxxxxxGEPI WIPFAFKHDPSNTDCHGRQYVKRTWYKKFVGVILCNSLRYKIYLSDNL-K -DTFYSIGDSWGRGEDHCQFVDSHLDGRTGPQSYVEALPTIQGYYRQYRQ EPVSFGNIGFGTPYYYVGWYECGVSIPGKW-------------------- -------------------------------------------------- ------------------------ >ENSCGRP00015015283 -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ----MGLKVTWDPPKDATSRPV----EYYN-------------------- ----------------------------------I-AYGKS--------- --------------------------------------LK---------- -----------SLKYIKVNSETNSFLIEDV-------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- --------------------------xKEVPNKPVRLRVRAS-------- -----------------------------------------------DDR LSVAWKAPRL-SGAKS-------PR-RSRGFLLGYG-----ESGRKMNY- -----------VPLTRDERSHEIKKL---ASESV---------------- ---------YVVSLQSTN-----------------SQGQSQPVYRAALTK RKNSED-------SELDLPEDISVRVMSSQSVLVAWVDPLVE-KQKxxx- -TS-RQYTVRYREKGESARWDYKQVSNRRALVDGLLPDTVYEFAVRISQG ERDGKWSASIFQRTPESAPTIAPENLNVWPVSGKPTAVTVSWDALPETEG KVKEYILSYAPALKPFGAKSLTFSGHTTSAMVDGLQPGERYLFKIRATNR RGPGPHSKAFIVTIPT-----------T-SSTEASAHQ--NGGNSWKPEQ Sx----------------------------------------------xx xxxPKAAT---------SSEHT---------------------------- -------------------------------PPAKNAKDVLLDLKNKILA NGGPPRKTHLHS-KMGAx---xxx------EVTG-------EEELDSLED PRPAQSE-------------TLD--------------------------- -QRRPLRI--PSRPGHRVLAPGRTPARAGLPVLPRKEGMDR-GGPSxVPY --------PR---------------------------------------x xxxxxxxx-x-------------x-------------------------- ---------------------------------------------xx--- ------------------------x------------------------- -------------------------------------------------- ------------------------xxxN---------------------- ----------------------DSVSQNEHDQE---------xxxx---- -------------------------------------------------- -------------------------------------xx----------- ---------------------------------------------xxxxx x-xxxx-------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -----------xxxxxxxx-----------------PSRHVASNxxxxxx xxxxxxxx------xxxxxxxxxxxxx----------------------- ----------------------------xxxxxxxxx------------- ------xxx---------------------------HFPLHRGSSR---- -Pxxxx-----------QLxxxxxxxxxxxxxxxx--------------- xxxxxxxxxxxxxxxxxxxxxxxxxxx----------------------- -------------------------------------------------- -------------------------------------------------- ---------------------------------------------xxxxx xxxxxAGDTRRQAEATAQxQQT---------x------------------ ----------------------PALGxxxxxRNKPFATHSRNPNRFPRFR GLxxxPxxx---xxx---TSASKVL------------------------- -------------------------------------------------- xxxxxxxTS-------------------------------xxxxxPDVxG x--------------------------xxDEEPxx-------------xx -------------------------------------------------- -------------------------------VVNDR-S------------ P-----------------SSS------------------RHPASGGWDTL RRGPQRGAxxxxKEPIPxxP------------------------------ -----------xxx------------------------------------ ------------------------------------------------xx --------------------------xxxxxxx----------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------xxxSxxxxxxxxx-xxxxx----xRTSPGSTSRQLxx xxx----------------------------------------------- -------------------------------------------------- -PAS---------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------Rxxx--------------------------- -------------------------------------------------- -------------------------------------------------- -xxx-xxVxxRLAxxxxxxxx----------------------------- -----xxxxxxxxxxxxxxxxxxx-------------------------- ---------------------------------------------xxxxx x------------------------------------------------- -------------------------------------------------- ---------------------------xxx-------------------- ---------xxx--------------------xxxxxxxxxxx------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -x------------------------------------------------ --------------------xxxxx------------------------- -----------------------------------------------xxx xxxx-----------------------------------------xxxxx xxxxxxxxxx---------------------------------------- ----------------------------xxx------------------- -------------------------------------------------- --------------------------------xxxxxxxxxxx------- --------------------------xxxxxx---xxxxxxxxx------ -------------------------------------------------- -------------------------------------------------- --------------------------------------x----------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ------------xxxx---------------------------------- -------------------------------------------------- --------------------------x----------------------- -------------------------------------------xx----- --------------xxxRAQVS---------------------------- -----------------------------------SRAG----------x xxxP--VKKISPSKGPLxx------------------------------- ----------ESQQSVFIExx-------------xxx-xxxxxxxxx-xx x-xALTxSVSKWPSxxP-HRNNKYADR-xxxxxxxxx------------- ---------------------------------------xx--------- ---xxxxxxxxxxxxxx--------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ----------------------------------------PG-------- -------------------------------------------------x x----x-x------------------------------------------ -------------------------------------------------- ------------------------------x------------------x x--xxxSHxxxxxxS-----------xxx--------------------- -------xxxx--------------------------------------- ---xxxxxxxWPR-------------------------------YxxRAP PSY-----------------------------------------xxT-x- -------------------------------------------------- ------------------------------xML----------SLRQRxx x------------------------RFRTPV-----SRQ----------- --xx---------------------------------------------- -------------------------------------------------- ------xRPVL------A------Q------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ---------------------GYNGRPNI-------------EEH---IP PGGIGKPNGQRVINGPQGTKWVVDLDRGLVFNAEGRYLQDSHGNPLRVRL GGDGRTIVDLGGTPMVSPDGLPLFGQGRHGKPLASAQDKPILSLGGKPLV GLE--VIKTTTHLP-TT-----TMxx---------xxxxxxxx------- xx--xxxxxxxxx---xx----xx---xxx-----xxxxxxTTT------ ---------------------------------Rxxx-xxxx-------x xxxxx--------xxxx----------------xxx--xx---------- xxxxx-------------xx------------------------------ -PSPTCPPGTLEHQDEAGNLIM-GSNGIPECY------------------ --------P-------------------------EEDEFSGLETD----- ---TxxPMEEDYVVYDG------------------------D-------- YG-FE-ATR-------P-----P---x----------xxxxS-------- -----------------------------------TTA--Txxx------ -----xIPEQGT----------------------V--------------- -----SSFPEEEFDLAGKKRFI--------------------------AP YVTYLSKDPSAPCSLTDALDHFQVESLDELIPND--LTKNELPPQHAPRN ITVVAMEGCHSFVIVDWNKAIPGDVVTGYLVYSASYEDFIRNKWSTQTSS VTHLPIENLKPNT------------------------------RYYFKVQ AKNPHGYGPVSPSVSFVTESDNPLLVVRPPG---------------GEPI WIPFAFKHDPGYTDCHGRQYVKRTWYKKFVGVVLCNSLRYKIYLSDNL-K -DTFYSIGDSWGRGEDHCQFVDSHLDGRTGPQSYVEALPTIQGYHRQYRQ EPVSFGNIGFGTPYYYVGWYECGVSIPGKW-------------------- -------------------------------------------------- ------------------------ >ENSCGRP00000024470 -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ----MGLKVTWDPPKDATSRPV----EHYN-------------------- ----------------------------------I-AYGKS--------- --------------------------------------LK---------- -----------SLKYIKVNSETNSFLIEDV-------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- --------------------------xKEVPNKPVRLRVRAS-------- -----------------------------------------------DDR LSVAWKAPRL-SGAKS-------PR-RSRGFLLGYG-----ESGRKMNY- -----------VPLTRDERSHEIKKL---ASESV---------------- ---------YVVSLQSTN-----------------SQGQSQPVYRAALTK RKNSED-------SELDLPEDISVRVMSSQSVLVAWVDPLVE-KQKxxx- -TS-RQYTVRYREKGESARWDYKQVSNRRALVDGLLPDTVYEFAVRISQG ERDGKWSASIFQRTPESAPTIAPENLNVWPVSGKPTAVTVSWDALPETEG KVKEYILSYAPALKPFGAKSLTFSGHTTSAMVDGLQPGERYLFKIRATNR RGPGPHSKAFIVTIPT-----------T-SSTEASAHQ--NGGNSWKPEQ Sx----------------------------------------------xx xxxPKAAT---------SSEHT---------------------------- -------------------------------PPAKNAKDVLLDLKNKILA NGGPPRKTHLHS-xxxxx---xxx------EVTG-------EEELDSLED PRPAQSE-------------TLD--------------------------- -QRRPLRI--PSRPGHRVLAPGRTPARAGLPVLPRKEGMDR-RGPSxVPY --------PR---------------------------------------x xxxxxxxx-x-------------x-------------------------- ---------------------------------------------xx--- ------------------------x------------------------- -------------------------------------------------- ------------------------xxxN---------------------- ----------------------DSVSQNEHDQE---------xxxx---- -------------------------------------------------- -------------------------------------xx----------- ---------------------------------------------xxxxx x-xxxx-------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -----------xxxxxxxx-----------------PSRHVASNxxxxxx xxxxxxxx------xxxxxxxxxxxxx----------------------- ----------------------------xxxxxxxxx------------- ------xxx---------------------------HFPLHRGSSR---- -Pxxxx-----------QLxxxxxxxxxxxxxxxx--------------- xxxxxxxxxxxxxxxxxxxxxxxxxxx----------------------- -------------------------------------------------- -------------------------------------------------- ---------------------------------------------xxxxx xxxxxAGDTRRQAEATAQxQQT---------x------------------ ----------------------PALGxxxxxRNKPFATHSRNPNRFPRFR GLxxxPxxx---xxx---TSASKVL------------------------- -------------------------------------------------- xxxxxxxTS-------------------------------xxxxxPDVxR x--------------------------xxDEEPxP-------------xx -------------------------------------------------- -------------------------------VVNDR-T------------ P-----------------SSS------------------RHPASGGWDTL RRGPQRGAxxxxKEPIPxxP------------------------------ -----------xxx------------------------------------ ------------------------------------------------xx --------------------------xxxxxxx----------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------xxxSxxxxxxxxx-xxxxx----xRTSPGSTSRQLxx xxx----------------------------------------------- -------------------------------------------------- -PAS---------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------Rxxx--------------------------- -------------------------------------------------- -------------------------------------------------- -xxx-xxVxxRLAxxxxxxxx----------------------------- -----xxxxxxxxxxxxxxxxxxx-------------------------- ---------------------------------------------xxxxx x------------------------------------------------- -------------------------------------------------- ---------------------------xxx-------------------- ---------xxx--------------------xxxxxxxxxxx------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -x------------------------------------------------ --------------------xxxxx------------------------- -----------------------------------------------xxx xxxx-----------------------------------------xxxxx xxxxxxxxxx---------------------------------------- ----------------------------xxx------------------- -------------------------------------------------- --------------------------------xxxxxxxxxxx------- --------------------------xxxxxx---xxxxxxxxx------ -------------------------------------------------- -------------------------------------------------- --------------------------------------x----------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ------------xxxx---------------------------------- -------------------------------------------------- --------------------------x----------------------- -------------------------------------------xx----- --------------xxxRAQVS---------------------------- -----------------------------------SRAG----------x xxxP--VKKISPSKGPLxx------------------------------- ----------ESQQSVFIExx-------------xxx-xxxxxxxxx-xx x-xALTxSVSKWPSxxP-HRNNKYADR-xxxxxxxxx------------- ---------------------------------------x---------- ---------xxxxxxxx--------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ----------------------------------------PG-------- -------------------------------------------------x x----x-x------------------------------------------ -------------------------------------------------- ------------------------------x------------------x x--xxxSHxxxxxxS-----------xxx--------------------- -------xxxx--------------------------------------- ---xxxxxxxWPR-------------------------------YxxRAP PSY-----------------------------------------xxT-x- -------------------------------------------------- ------------------------------xML----------SLRQRxx x------------------------RFRTPV-----SRQ----------- --xx---------------------------------------------- -------------------------------------------------- ------xRPVL------A------Q------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ---------------------GYNGRPNI-------------EEH---IP PGGIGKPNGQRVINGPQGTKWVVDLDRGLVFNAEGRYLQDSHGNPLRVRL GGDGRTIVDLGGTPMVSPDGLPLFGQGRHGKPLASAQDKPILSLGGKPLV GLE--VIKTTTHLP-TT-----TMxx---------xxxxxxxx------- xx--xxxxxxxxx---xx----xx---xxx-----xxxxxxTTT------ ---------------------------------Rxxx-xxxx-------x xxxxx--------xxxx----------------xxx--xx---------- xxxxx-------------xx------------------------------ -PSPTCPPGTLEHQDEAGNLIM-GSNGIPECY------------------ --------P-------------------------EEDEFSGLETD----- ---TxxPMEEDYVVYDD------------------------D-------- YG-FE-ATR-------P-----P---x----------xxxxS-------- -----------------------------------TTA--Txxx------ -----xIPEQGT----------------------V--------------- -----SSFPEEEFDLAGKKRFI--------------------------AP YVTYLSKDPSAPCSLTDALDHFQVESLDELIPND--LTKNELPPQHAPRN ITVVAMEGCHSFVIVDWNKAIPGDVVTGYLVYSASYEDFIRNKWSTQTSS VTHLPIENLKPNT------------------------------RYYFKVQ AKNPHGYGPVSPSVSFVTESDNPLLVVRPPG---------------GEPI WIPFAFKHDPGYTDCHGRQYVKRTWYKKFVGVVLCNSLRYKIYLSDNL-K -DTFYSIGDSWGRGEDHCQFVDSHLDGRTGPQSYVEALPTIQGYHRQYRQ EPVSFGNIGFGTPYYYVGWYECGVSIPGKW-------------------- -------------------------------------------------- ------------------------ >ENSCGRP00001003549 -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ----MGLKVTWDPPKDATSRPV----EHYN-------------------- ----------------------------------I-AYGKS--------- --------------------------------------LK---------- -----------SLKYIKVNSETNSFLIEDV-------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- --------------------------xKEVPNKPVRLRVRAS-------- -----------------------------------------------DDR LSVAWKAPRL-SGAKS-------PR-RSRGFLLGYG-----ESGRKMNY- -----------VPLTRDERSHEIKKL---ASESV---------------- ---------YVVSLQSTN-----------------SQGQSQPVYRAALTK RKNSED-------SELDLPEDISVRVMSSQSVLVAWVDPLVE-KQKxxx- -TS-RQYTVRYREKGESARWDYKQVSNRRALVDGLLPDTVYEFAVRISQG ERDGKWSASIFQRTPESAPTIAPENLNVWPVSGKPTAVTVSWDALPETEG KVKEYILSYAPALKPFGAKSLTFSGHTTSAMVDGLQPGERYLFKIRATNR RGPGPHSKAFIVTIPT-----------T-SSTEASAHQ--NGGNSWKPEQ Sx----------------------------------------------xx xxxPKAAT---------SSEHT---------------------------- -------------------------------PPAKNAKDVLLDLKNKILA NGGPPRKTHLHS-KMGAL---DPQ------EVTG-------EEELDSLED PRPAQSE-------------TLD--------------------------- -QRRPLRI--PSRPGHRVLAPGRTPARAGLPVLPRKEGMDR-RGPSxVPY --------PR---------------------------------------x xxxxxxxx-x-------------x-------------------------- ---------------------------------------------xx--- ------------------------x------------------------- -------------------------------------------------- ------------------------xxxN---------------------- ----------------------DSVSQNEHDQE---------xxxx---- -------------------------------------------------- -------------------------------------xx----------- ---------------------------------------------xxxxx x-xxxx-------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -----------xxxxxxxx-----------------PSRHVASNxxxxxx xxxxxxxx------xxxxxxxxxxxxx----------------------- ----------------------------xxxxxxxxx------------- ------xxx---------------------------HFPLHRGSSR---- -Pxxxx-----------QLxxxxxxxxxxxxxxxx--------------- xxxxxxxxxxxxxxxxxxxxxxxxxxx----------------------- -------------------------------------------------- -------------------------------------------------- ---------------------------------------------xxxxx xxxxxAGDTRRQAEATAQxQQT---------x------------------ ----------------------PALGxxxxxRNKPFATHSRNPNRFPRFR GLxxxPxxx---xxx---TSASKVL------------------------- -------------------------------------------------- xxxxxxxTS-------------------------------xxxxxPDVxR x--------------------------xxDEEPxP-------------xx -------------------------------------------------- -------------------------------VVNDR-T------------ P-----------------SSS------------------RHPASGGWDTL RRGPQRGAxxxxKEPIPxxP------------------------------ -----------xxx------------------------------------ ------------------------------------------------xx --------------------------xxxxxxx----------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------xxxSxxxxxxxxx-xxxxx----xRTSPGSTSRQLxx xxx----------------------------------------------- -------------------------------------------------- -PAS---------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------Rxxx--------------------------- -------------------------------------------------- -------------------------------------------------- -xxx-xxVxxRLAxxxxxxxx----------------------------- -----xxxxxxxxxxxxxxxxxxx-------------------------- ---------------------------------------------xxxxx x------------------------------------------------- -------------------------------------------------- ---------------------------xxx-------------------- ---------xxx--------------------xxxxxxxxxxx------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -x------------------------------------------------ --------------------xxxxx------------------------- -----------------------------------------------xxx xxxx-----------------------------------------xxxxx xxxxxxxxxx---------------------------------------- ----------------------------xxx------------------- -------------------------------------------------- --------------------------------xxxxxxxxxxx------- --------------------------xxxxxx---xxxxxxxxx------ -------------------------------------------------- -------------------------------------------------- --------------------------------------x----------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ------------xxxx---------------------------------- -------------------------------------------------- --------------------------x----------------------- -------------------------------------------xx----- --------------xxxRAQVS---------------------------- -----------------------------------SRAG----------x xxxP--VKKISPSKGPLxx------------------------------- ----------ESQQSVFIExx-------------xxx-xxxxxxxxx-xx x-xALTxSVSKWPSxxP-HRNNKYADR-xxxxxxxxx------------- ---------------------------------------x---------- ---------xxxxxxxx--------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ----------------------------------------PG-------- -------------------------------------------------x x----x-x------------------------------------------ -------------------------------------------------- ------------------------------x------------------x x--xxxSHxxxxxxS-----------xxx--------------------- -------xxxx--------------------------------------- ---xxxxxxxWPR-------------------------------YxxRAP PSY-----------------------------------------xxT-x- -------------------------------------------------- ------------------------------xML----------SLRQRxx x------------------------RFRTPV-----SRQ----------- --xx---------------------------------------------- -------------------------------------------------- ------xRPVL------A------Q------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ---------------------GYNGRPNI-------------EEH---IP PGGIGKPNGQRVINGPQGTKWVVDLDRGLVFNAEGRYLQDSHGNPLRVRL GGDGRTIVDLGGTPMVSPDGLPLFGQGRHGKPLASAQDKPILSLGGKPLV GLE--VIKTTTHLP-TT-----TMxx---------xxxxxxxx------- xx--xxxxxxxxx---xx----xx---xxx-----xxxxxxTTT------ ---------------------------------Rxxx-xxxx-------x xxxxx--------xxxx----------------xxx--xx---------- xxxxx-------------xx------------------------------ -PSPTCPPGTLEHQDEAGNLIM-GSNGIPECY------------------ --------P-------------------------EEDEFSGLETD----- ---TxxPMEEDYVVYDD------------------------D-------- YG-FE-ATR-------P-----P---x----------xxxxS-------- -----------------------------------TTA--Txxx------ -----xIPEQGT----------------------V--------------- -----SSFPEEEFDLAGKKRFI--------------------------AP YVTYLSKDPSAPCSLTDALDHFQVESLDELIPND--LTKNELPPQHAPRN ITVVAMEGCHSFVIVDWNKAIPGDVVTGYLVYSASYEDFIRNKWSTQTSS VTHLPIENLKPNT------------------------------RYYFKVQ AKNPHGYGPVSPSVSFVTESDNPLLVVRPPG---------------GEPI WIPFAFKHDPGYTDCHGRQYVKRTWYKKFVGVVLCNSLRYKIYLSDNL-K -DTFYSIGDSWGRGEDHCQFVDSHLDGRTGPQSYVEALPTIQGYHRQYRQ EPVSFGNIGFGTPYYYVGWYECGVSIPGKW-------------------- -------------------------------------------------- ------------------------ >ENSMAUP00000002800 -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ----------------------------------------xx-------- ---xxxxx---xxxx-xxxxx-xxxxxxxxPxxxxxx-xx---------- -------------------------------------------------- --------VDHPL------------------------------KPRHVKL LSTKMGLKVTWDPPKDATSRPV----EHYN-------------------- ----------------------------------I-AYGKS--------- --------------------------------------LK---------- -----------SLKYIKVNAETNSFLIEDV-------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- --------------------------xKEVPNKPVRLRVRAS-------- -----------------------------------------------DDR LSVAWKAPRL-SGAKS-------PR-RSRGFLLGYG-----ESGRKMNY- -----------VPLTRDERSHEIKKL---ASESV---------------- ---------YVVSLQSTN-----------------SQGQSQPVYRAALTK RKNSED-------SELDLPEDISVRVISSQSVLVAWVDPLVE-KQKxxx- -AS-RQYTVRYREKGESARWDYKQVSNRRALVDSLLPDTVYEFAVRISQG ERDGKWSASIFQRTPESAPTIAPENLKVWPVSGKPTAVTVSWDALPETEG RVKEYILSYAPALKPFGAKSLTFSGHTTSAMVDGLQPGERYLFKIRATNR RGQGPHSKAFIVTVPT-----------T-GSTEAKAHQ--DGGNSWKPER Px----------------------------------------------xx xxxPKATT---------SSEHT---------------------------- -------------------------------SPAKNAKDVLLDLKNKILA NGGPPRKPQLHS-KMGAx---xxx------EVTG-------EEELDSLED PRPPRSE-------------TLD--------------------------- -QRRPLRI--PSRSGHWVPAPGRTPARAGLPVLPRKEGMDR-RGPSxAPH --------PR---------------------------------------x xxxxxxxx-x-------------x-------------------------- ---------------------------------------------xx--- ------------------------x------------------------- -------------------------------------------------- ------------------------xxxN---------------------- ----------------------DSVNQNEDDxx---------xxxx---- -------------------------------------------------- -------------------------------------xx----------- ---------------------------------------------xxxxx x-xxxx-------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -----------xxxxxxxx-----------------PSRHVASNxxxxxx xxxxxxxx------xxxxxxxxxxxxx----------------------- ----------------------------xxxxxxxxx------------- ------xxx---------------------------HFPLHRG------- -----x-----------Qxxxxxxxxxxxxxxxxx--------------- xxxxxxxxxxxxxxxxxxxxxxxxxxx----------------------- -------------------------------------------------- -------------------------------------------------- ---------------------------------------------xxxxx xxxxxAGDTRRQAEATAHxQQT---------x------------------ ----------------------PALGxxxxxRNKPFATHSRTPNRSPRVR GLxxxPxxx---xxx---TSASKVL------------------------- -------------------------------------------------- xxxxxxxAS-------------------------------xxxxxSDVxG x--------------------------xxDEEPxP-------------xx -------------------------------------------------- -------------------------------VVTDP-T------------ P-----------------SSS------------------RHPASGGWDTL RRGPQRGAxxxxKEPIPxxP------------------------------ -----------xxx------------------------------------ ------------------------------------------------xx --------------------------xxxxxxx----------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------xxxSxxxxxxxxx-xxxxx----xRTSPGSSSRQLxx xxx----------------------------------------------- -------------------------------------------------- -PAS---------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------Rxxx--------------------------- -------------------------------------------------- -------------------------------------------------- -xxx-xxVxxRLAxxxxxxxx----------------------------- -----xxxxxxxxxxxxxxxxxxx-------------------------- ---------------------------------------------xxxxx x------------------------------------------------- -------------------------------------------------- ---------------------------xxx-------------------- ---------xxx--------------------xxxxxxxxxxx------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -x------------------------------------------------ --------------------xxxxx------------------------- -----------------------------------------------xxx xxxx-----------------------------------------xxxxx xxxxxxxxxx---------------------------------------- ----------------------------xxx------------------- -------------------------------------------------- --------------------------------xxxxxxxxxxx------- --------------------------xxxxxx---xxxxxxxxx------ -------------------------------------------------- -------------------------------------------------- --------------------------------------x----------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ------------xxxx---------------------------------- -------------------------------------------------- --------------------------x----------------------- -------------------------------------------xx----- --------------xxxQAQVS---------------------------- -----------------------------------SRAG----------x xxxP--VKKISPSKxx--x------------------------------- ----------ESQQSVF-xxx-------------xxx-xxxxxxxxx-xx x-xSLTxSISKWPPxxP-HRNNKYADR-xxxxxxxxx------------- ---------------------------------------x---------- ---------xxxxxxx---------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -----------------------------------------G-------- -------------------------------------------------x x----x-x------------------------------------------ -------------------------------------------------- ------------------------------x------------------x x--xxxSHxxxxxxP-----------xxx--------------------- -------xxxx--------------------------------------- ---xxxxxxxWPR-------------------------------YxxRAP PSY-----------------------------------------xxT-x- -------------------------------------------------- ------------------------------xML----------SLRQRxx x------------------------RFRTPV-----SRQ----------- --xx---------------------------------------------- -------------------------------------------------- ------xRPVL------A------Q------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ---------------------GYNGRPNV-------------EEN---IP PGSIGKPNGQRIINGPQGTKWVVDLDRGLVFNAEGRYLQDSHGNPLRVRL GGDGRTIVDLGGTPMVSPDGLPLFGQGRHGKPLASAQDKPILSLGGKPLV GLE--VIKTTT-----------------------------xxx------- xx--xxxxxxxxx---xxxxxxxx---xxx-----xxxxxxxTT------ 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-------------------------------------------------- --------------------------xREVPNKPVRMRVRAS-------- -----------------------------------------------DDR LSVAWKAPRL-SGAKS-------PR-RSRGFLLGYG-----ESGRKMNY- -----------VPLTRDERSHEIKKL---ASESV---------------- ---------YVVSLQSTN-----------------SQGPSQPVYRAALTK RKNSED-------SELDVPEDISVRVMSSQSVLVAWVDPLVE-KQKxxx- -AS-RQYTVRYREKGESARWDYKQVSNRRVLVDNLIPDTVYEFAVRISQG ERDGKWSASIFQRTPESAPTTAPENLNVWPVSGKSTVVTVSWDALPETEG KVKEYILSYAPALKPFGAKSLTFSGHTTSALVDGLQPGERYLFKIRATNR RGQGPHSKAFIVTMPT-----------T-SSTEASPRQ--DGRN-----K Px----------------------------------------------xx xxxPKTAA---------SSEPT---------------------------- -------------------------------PPAKNVKDVLLDLKNKILA NGGLPRKSQLRS-KQGEL---DPQA----TEVTG-------EEELDSLED PRSLRLE-------------TLD--------------------------- -QRRPLRV--PSRSGPWVPASGRTPSRAGPPVPPRKEGMDR-RGPSxVPH --------PR---------------------------------------x xxxxxxxx-x-------------xx------------------------- 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-------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ----MGLKVTWDPPKDASSRPV----EYYN-------------------- ----------------------------------I-AYGKS--------- --------------------------------------LK---------- -----------SLKSIKVNAETHSFLIKDV-------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- --------------------------xKEVPNKPLRMRVRAS-------- -----------------------------------------------DDR LSVAWKAPRL-SGAKS-------PR-RSRGFLLGYG-----ESGRKMNY- -----------VPLTRDERSHEIKKL---ASESV---------------- ---------YVVSLQSTN-----------------SQGQSQPVYRAALTK RKHAEE-------DELDVPEDISVRVMSSQSVLVAWVDPLVE-KQKxxx- -AS-RQYTVRYREKGESARWDYKQVSNRRVLVDSLIPDTVYEFAVRISQG ERDGKWSASIFQRTPESAPTTAPENLRVWPVSGKPTVVTVSWDALPESEG KVKEYILSYAPALKPFGAKSLTFSGHTTSALVDGLQPGERYLFKIRATNR RGPGPHSKAFIVAIPT-----------T-SSTEASAQP--NGRDS----- ---------------------------------------xxxxxxxxxxx xxxPKVAA---------SSEHT---------------------------- -------------------------------PSAKNVKDALSDL-NKIRT NSVVPGKTQLHS-KMGEL---DPQS----TEVTG-------EEELDSLED PRSSRLE-------------TLN--------------------------- -QKQPLRV--PSRSGHGVLTPGRTPARTGLPVLPRKEVMDR-RGPSxDPH --------LR---------------------------------------x xxxxxx---x-------------xx------------------------- 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-------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ----MGLKVTWDPPKDASSRPV----EYYN-------------------- ----------------------------------I-AYGKS--------- --------------------------------------LK---------- -----------SLKSIKVNAETHSFLIKDV-------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- --------------------------xKEVPNKPLRMRVRAS-------- -----------------------------------------------DDR LSVAWKAPRL-SGAKS-------PR-RSRGFLLGYG-----ESGRKMNY- -----------VPLTRDERSHEIKKL---ASESV---------------- ---------YVVSLQSTN-----------------SQGQSQPVYRAALTK RKHAEE-------DELDVPEDISVRVMSSQSVLVAWVDPLVE-KQKxxx- -AS-RQYTVRYREKGESARWDYKQVSNRRVLVDSLIPDTVYEFAVRISQG ERDGKWSASIFQRTPESAPTTAPENLRVWPVSGKPTVVTVSWDALPESEG KVKEYILSYAPALKPFGAKSLTFSGHTTSALVDGLQPGERYLFKIRATNR RGPGPHSKAFIVAIPT-----------T-SSTEASAQP--NGRDS----- ---------------------------------------xxxxxxxxxxx xxxPKVAV---------SLEHT---------------------------- -------------------------------PSAKNVKDALSDLKNKIRT NGVVPGKTQLHS-KMGEL---DPQS----TEVTG-------EEELDSLED PRSSRLE-------------TLN--------------------------- -QKQPLRV--PSRSGHGVLAPGRTPARTGLPVLPRKEVMDR-RGPSxDPH --------LR---------------------------------------x xxxxxx---x-------------xx------------------------- 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-------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ----MGLKVTWDPPKDASSRPV----EYYN-------------------- ----------------------------------I-AYGKS--------- --------------------------------------LK---------- -----------NLKSIKVNAETHSFLIKDV-------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- --------------------------xKEVPNKPLRMRVRAS-------- -----------------------------------------------DDR LSVAWKAPRL-SGAKS-------PR-RSRGFLLGYG-----ESGRKMNY- -----------VPLTRDERSHEIKKL---ASESV---------------- ---------YVVSLQSTN-----------------SQGQSQPVYRAALTK RKHAEE-------DELDVPEDISVRVMSSQSVLVAWVDPLVE-KQKxxx- -AS-RQYTVRYREKGESARWDYKQVSNRRVLVDSLIPDTVYEFAVRISQG ERDGKWSASIFQRTPESAPTTAPENLRVWPVSGKPTVVTVSWDTLPESEG KVKEYILSYAPALKPFGAKSLTFSGHTTSALVDGLQPGERYLFKIRATNR RGPGPHSKAFIVAIPT-----------T-SSTEASAQP--DGRDS----- ---------------------------------------xxxxxxxxxxx xxxPKVAA---------SSKHT---------------------------- -------------------------------PSAKNVKDALSDL-NKIRT NGVVPGKTQLHS-KMGEL---DPQS----TEVTG-------EEELDSLED PRSSRLE-------------TLN--------------------------- -QKQPLRV--PSRSGHGVLAPGRTPARTGLPVLPRKEVMDR-RGPSxDPH --------LR---------------------------------------x xxxxxx---x-------------xx------------------------- 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