>ENSP00000328992 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------MF----- ------------------------------------------------------------ --------------------RKARRVNVRKRNDSEEEE-------RER------------ -------------------------------------------------------DEEQE ----------------------------------------PP------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------P--------------- ------------------------------------------------------------ -----------LL----------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------------PP ------------------------------------------------------------ ------------------------------------------------------------ ----------P-------------------GT---------------------------- ------------------------------------------------------------ ----------------GEEA-----GP--------------------------------- -----------------------------------GGG--------DRA----------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------P-------------------------------------------- ---------------GGESL---------------------------------------- ------------------------------------LGPGP-------------SPP--- ------------------------------------------------------------ ---SA-------------LTPGL------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------GAEAGGGFPGGAEPGNGLKPRKR PRENKE--VP-------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------RAS----------------- ------------------LLSF-QDE-EE-EN---------------------------- ---------------------------------------------------------E-- ------EVFKVKKSSYSKKIVKLLKKEYKE------------------------------ ----------------------DLEKSK-------------------------------- ------------------------------------------------------------ ---------------------IKTELN-----------S--------------------- -------------------SAESEQPLDKTGHVKDTNQEDGVIISEHGEDEMDMES---- EKEEE------------------------------------------------------K PKT-GGAFS--------------------------------------------------- -------NALSSLNVLRP-----------GEIPDAAFIHAARKKRQMARELGDFTP-HDN E-PGKGRLVR-ED--ENDA-SD-DEDDDEKRRIVFSVKEKSQRQKIAEE--I---GIEGS DDDALV-TGEQDEELSRWEQEQIRKGINIPQVQASQPAEV-NMYYQNTYQTMPYGSSYGI PYSY--TAY-----------------------------GSS-DAKSQKTDNTVPFKTPSN EMTPVTIDLVKKQLKD-R------------------------------------------ ----------------------LDSMKELHKTNRQQHEKHLQSRVDSTRAIERLEGSSGG IGERYKFLQEMRGYVQDLLECFSEKVPLINELESAIHQLYKQRASRLVQRRQDDIKDESS EFSSHS-------------------NKALMAPNLDSFGRDRALYQEHAK-RRIAERE--- ---ARR-TRR-RQAREQTGKMADHLEGLSSDDEETSTDITNFNLEK--DRISKESGKVFE DVLESFYSIDCIKSQFEAWRSKYYTSYKDAYIGLCLPKLFNPLIRLQLLTWTPLE----- -------------------------------AKCRDFENMLWFESLLFYGCEERE--QEK DDVDVALLPTIVEKVILPKLTVIAENMWDPFSTT--------------QTSRMVGITLKL INGYPSVVNAENKN-----TQVYLKALLLRMRRTLDDDVFMPLYPKNVLENKNSGPYLFF QRQFWSSVKLLGNFLQWYGIFSNKTLQELSIDGLLNRYILMAFQNSEYGDDSIKKAQNVI NCFPKQWFMNLKGERTISQLENFCRYLVHLADTIYRNSIGCSDVEKRNARENIKQIVKLL ASVRALDHAMSVASDH----------------N------------VKEFKSLIEGK-- >ENSPTRP00000070437 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------MF----- ------------------------------------------------------------ --------------------RKARRVNVRKRNDSEEEE-------RER------------ -------------------------------------------------------DEEQE ----------------------------------------PP------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------P--------------- ------------------------------------------------------------ -----------LL----------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------------PP ------------------------------------------------------------ ------------------------------------------------------------ ----------P-------------------GT---------------------------- ------------------------------------------------------------ ----------------GEEA-----GP--------------------------------- -----------------------------------CGG--------DRA----------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------P-------------------------------------------- ---------------GGESL---------------------------------------- ------------------------------------LGPGP-------------SPP--- ------------------------------------------------------------ ---SA-------------LTPGL------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------GAEAGGGFPGGAEPGNGLKPRKR PRENKE--VP-------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------RAS----------------- ------------------LLSF-QDE-EE-EN---------------------------- ---------------------------------------------------------E-- ------EVFKVKKSSYSKKIVKLLKKEYKE------------------------------ ----------------------DLEKSK-------------------------------- ------------------------------------------------------------ ---------------------IKTELN-----------S--------------------- -------------------SAESEQPLDKTGHVKDTNQEDGVIISEHGEDEMDMES---- EKEEE------------------------------------------------------K PKT-GGAFS--------------------------------------------------- -------NALSSLNVLRP-----------GEIPDAAFIHAARKKRQMARELGDFTP-HDN E-PGKGRLVR-ED--ENDA-SD-DEDDDEKRRIVFSVKEKSQRQKIAEE--I---GIEGS DDDALV-TGEQDEELSRWEQEQIRKGINIPQVQASQPAEV-NMYYQNTYQTMPYGSSYGI PYSY--TAY-----------------------------GSS-DAKSQKTDNTVPFKTPSN EMTPVTIDLVKKQLKD-R------------------------------------------ ----------------------LDSMKELHKTNRQQHEKHLQSRVDSTRAIERLEGSSGG IGERYKFLQEMRGYVQDLLECFSEKVPLINELESAIHQLYKQRASRLVQRRQDDIKDESS EFSSHS-------------------NKALMAPNLDSFGRDRALYQEHAK-RRIAERE--- ---ARR-TRR-RQAREQTGKMADHLEGLSSDDEETSTDITNFNLEK--DRISKESGKVFE DVLESFYSIDCIKSQFEAWRSKYYTSYKDAYIGLCLPKLFNPLIRLQLLTWTPLE----- -------------------------------AKCRDFENMLWFESLLFYGCEERE--QEK DDVDVALLPTIVEKVILPKLTVIAENMWDPFSTT--------------QTSRMVGITLKL INGYPSVVNAENKN-----TQVYLKALLLRMRRTLDDDVFMPLYPKNVLENKNSGPYLFF QRQFWSSVKLLGNFLQWYGIFSNKTLQELSIDGLLNRYILMAFQNSEYGDDSIKKAQNVI NCFPKQWFMNLKGERTISQLENFCRYLVHLADTIYRNSIGCSDVEKRNARENIKQIVKLL ASVRALDHAMSVASDH----------------N------------VKEFKSLIEGK-- >ENSPTRP00000023857 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------MF----- ------------------------------------------------------------ --------------------RKARRVNVRKRNDSEEEE-------RER------------ -------------------------------------------------------DEEQE ----------------------------------------PP------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------P--------------- ------------------------------------------------------------ -----------LL----------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------------PP ------------------------------------------------------------ ------------------------------------------------------------ ----------P-------------------GT---------------------------- ------------------------------------------------------------ ----------------GEEA-----GP--------------------------------- -----------------------------------CGG--------DRA----------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------P-------------------------------------------- ---------------GGESL---------------------------------------- ------------------------------------LGPGP-------------SPP--- ------------------------------------------------------------ ---SA-------------LTPGL------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------GAEAGGGFPGGAEPGNGLKPRKR PRENKE--VP-------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------RAS----------------- ------------------LLSF-QDE-EE-EN---------------------------- ---------------------------------------------------------E-- ------EVFKVKKSSYSKKIVKLLKKEYKE------------------------------ ----------------------DLEKSK-------------------------------- ------------------------------------------------------------ ---------------------IKTELN-----------S--------------------- -------------------SAESEQPLDKTGHVKDTNQEDGVIISEHGEDEMDMES---- EKEEE------------------------------------------------------K PKT-GGAFS--------------------------------------------------- -------NALSSLNVLRP-----------GEIPDAAFIHAARKKRQMARELGDFTP-HDN E-PGKGRLVR-ED--ENDA-SD-DEDDDEKRRIVFSVKEKSQRQKIAEE--I---GIEGS DDDALV-TGEQDEELSRWEQEQIRKGINIPQVQASQPAEV-NMYYQNTYQTMPYGSSYGI PYSY--TAY-----------------------------GSS-DAKSQKTDNTVPFKTPSN EMTPVTIDLVKKQLKD-R------------------------------------------ ----------------------LDSMKELHKTNRQQHEKHLQSRVDSTRAIERLEGSSGG IGERYKFLQEMRGYVQDLLECFSEKVPLINELESAIHQLYKQRASRLVQRRQDDIKDESS EFSSHS-------------------NKALMAPNLDSFGRDRALYQEHAK-RRIAERE--- ---ARR-TRR-RQAREQTGKMADHLEGLSSDDEETSTDITNFNLEK--DRISKESGKVFE DVLESFYSIDCIKSQFEAWRSKYYTSYKDAYIGLCLPKLFNPLIRLQLLTWTPLE----- -------------------------------AKCRDFENMLWFESLLFYGCEERE--QEK DDVDVALLPTIVEKVILPKLTVIAENMWDPFSTT--------------QTSRMVGITLKL INGYPSVVNAENKN-----TQVYLKALLLRMRRTLDDDVFMPLYPKNVLENKNSGPYLFF QRQFWSSVKLLGNFLQWYGIFSNKTLQELSIDGLLNRYILMAFQNSEYGDDSIKKAQNVI NCFPKQWFMNLKGERTISQLENFCRYLVHLADTIYRNSIGCSDVEKRNARENIKQIVKLL ASVRALDHAMSVASDH----------------N------------VKEFKSLIEGK-- >ENSGGOP00000016541 ------------------------------------------------------------ ------------------------------------------------------------ -----TAVRAA------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------GMF----- ------------------------------------------------------------ --------------------RKARRVNVRKRNDSEEEE-------RER------------ -------------------------------------------------------DEEQE ----------------------------------------PP------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------P--------------- ------------------------------------------------------------ -----------LL----------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------------PP ------------------------------------------------------------ ------------------------------------------------------------ ----------P-------------------GT---------------------------- ------------------------------------------------------------ ----------------GEEA-----GP--------------------------------- -----------------------------------GGG--------DRA----------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------P-------------------------------------------- ---------------GGESL---------------------------------------- ------------------------------------LGPGP-------------SPP--- ------------------------------------------------------------ ---SA-------------LTPGL------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------GAEAGGGFSGGAEPGNGLKPRKR PRENKE--VP-------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------RAS----------------- ------------------LLSF-QDE-EE-EN---------------------------- ---------------------------------------------------------E-- ------EVFKVKKSSYSKKIVKLLKKEYKE------------------------------ ----------------------DLEKSK-------------------------------- ------------------------------------------------------------ ---------------------IKTELN-----------S--------------------- -------------------SAESEQPLDKTGHVKDTNQEDGVIISEHGEDEMDMES---- EKEEE------------------------------------------------------K PKT-GGAFS--------------------------------------------------- -------NALSSLNVLRP-----------GEIPDAAFIHAARKKRQMARELGDFTP-HDN E-PGKGRLVR-ED--ENDA-SD-DEDDDEKRRIVFSVKEKSQRQKIAEE--I---GIEGS DDDALV-TGEQDEELSRWEQEQIRKGINIPQVQASQPAEV-NMYYQNTYQTMPYGSSYGI PYSY--TAY-----------------------------GSS-DAKSQKTDNTVPFKTPSN EMTPVTIDLVKKQLKD-R------------------------------------------ ----------------------LDSMKELHKTNRQQHEKHLQSRVDSTRAIERLEGSSGG IGERYKFLQEMRGYVQDLLECFSEKVPLINELESAIHQLYKQRASRLVQRRQDDIKDESS EFSSHS-------------------NKALMAPNLDSFGRDRALYQEHAK-RRIAERE--- ---ARR-TRR-RQAREQTGKMADHLEGLSSDDEETSTDITNFNLEK--DRISKESGKVFE DVLESFYSIDCIKSQFEAWRSKYYTSYKDAYIGLCLPKLFNPLIRLQLLTWTPLE----- -------------------------------AKCRDFENMLWFESLLFYGCEERE--QEK DDVDVALLPTIVEKVILPKLTVIAENMWDPFSTT--------------QTSRMVGITLKL INGYPSVVNAENKN-----TQVYLKALLLRMRRTLDDDVFMPLYPKNVLENKNSGPYLFF QRQFWSSVKLLGNFLQWYGIFSNKTLQELSIDGLLNRYILMAFQNSEYGDDSIKKAQNVI NCFPKQWFMNLKGERTISQLENFCRYLVHLADTIYRNSIGCSDVEKRNARENIKQIVKLL ASVRALDHAMSVASDH----------------N------------VKEFKSLIEGK-- >ENSCJAP00000017264 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------MF----- ------------------------------------------------------------ --------------------RKARRVNVRKRNDSEEEE-------RER------------ -------------------------------------------------------DEEQE ----------------------------------------PP------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------P--------------- ------------------------------------------------------------ -----------LL----------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------------PP ------------------------------------------------------------ ------------------------------------------------------------ ----------P-------------------GT---------------------------- ------------------------------------------------------------ ----------------GEEA-----GP--------------------------------- -----------------------------------GGS--------DRA----------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------P-------------------------------------------- ---------------GGESL---------------------------------------- ------------------------------------LGTGP-------------QPP--- ------------------------------------------------------------ ---SA-------------LTPGL------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------GAEAGGGFPGGAEPGNGLKPRKR PRENKE--VP-------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------RAS----------------- ------------------LLSF-QDE-EE-EN---------------------------- ---------------------------------------------------------E-- ------EVFKVKKSSYSKKIVKLLKKEYKE------------------------------ ----------------------DLEKSK-------------------------------- ------------------------------------------------------------ ---------------------IKTELN-----------S--------------------- -------------------SAESEQPLDKTGHVKDTNQEDGVIISEHGEDEMDMES---- EKEEE------------------------------------------------------K PKT-GGAFS--------------------------------------------------- -------NALSSLNVLRP-----------GEIPDAAFIHAARKKRQMARELGDFTP-HDN E-PGKGRLVR-ED--ENDA-SD-DEDDDEKRRIVFSVKEKSQRQKIAEE--I---GIEGS DDDALV-TGEQDEELSRWEQEQIRKGINIPQVQASQPAEV-NMYYQNTYQTMPYGSSYGI PYSY--TAY-----------------------------GSS-DAKSQKTDNTVPFKTPSN EMTPVTIDLVKKQLKD-R------------------------------------------ ----------------------LDSMKELHKTNRQQHEKHLQSRVDSTRAIERLEGSSGG IGERYKFLQEMRGYVQDLLECFSEKVPLINELESAIHQLYKQRASRLVQRRQDDIKDESS EFSSHS-------------------NKALMAPNLDSFGRDRALYQEHAK-RRIAERE--- ---ARR-TRR-RQAREQTGKMADHLEGLSSDDEETSTDITNFNLEK--DRISKESSKVFE DVLESFYSIDCIKSQFEAWRSKYYTSYKDAYIGLCLPKLFNPLIRLQLLTWTPLE----- -------------------------------AKCRDFENMLWFESLLFYGCEERE--QEK DDVDVALLPTIVEKVILPKLTVIAENMWDPFSTT--------------QTSRMVGITLKL ISGYPSVVNAENKN-----TQVYLKALLLRMRRTLDDDVFMPLYPKNVLENKNSGPYLFF QRQFWSSVKLLGNFLQWYGIFSNKTLQELSIDGLLNRYILMAFQNSEYGDDSIKKAQNVI NCFPKQWFMNLKGERTISQLENFCRYLVHLADTIYRNSIGCSDVEKRNARENIKQIVKLL ASVRALDHAMSVASDH----------------N------------VKEFKSLIEGK-- >ENSCCAP00000006442 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------MF----- ------------------------------------------------------------ --------------------RKARRVNVRKRNDSEEEE-------RER------------ -------------------------------------------------------DEEQE ----------------------------------------PP------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------P--------------- ------------------------------------------------------------ -----------LL----------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------------PP ------------------------------------------------------------ ------------------------------------------------------------ ----------P-------------------GT---------------------------- ------------------------------------------------------------ ----------------GEEA-----GP--------------------------------- -----------------------------------GGS--------DRA----------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------P-------------------------------------------- ---------------GGESL---------------------------------------- ------------------------------------LGPGP-------------PPP--- ------------------------------------------------------------ ---SA-------------LTPGL------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------GAEAGGGFPGGAEPGNGLKPRKR PRENKE--VP-------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------RAS----------------- ------------------LLSF-QDE-EE-EN---------------------------- ---------------------------------------------------------E-- ------EVFKVKKSSYSKKIVKLLKKEYKE------------------------------ ----------------------DLEKSK-------------------------------- ------------------------------------------------------------ ---------------------IKTELN-----------S--------------------- -------------------SAESEQPLDKTGHVKDTNQEDGVIISEHGEDEMDMES---- EKEEE------------------------------------------------------K PKA-GGAFS--------------------------------------------------- -------NALSSLNVLRP-----------GEIPDAAFIHAARKKRQMARELGDFTP-HDN E-PGKGRLVR-ED--ENDA-SD-DEDDDEKRRIVFSVKEKSQRQKIAEE--I---GIEGS DDDALV-TGEQDEELSRWEQEQIRKGINIPQVQASQPTEV-NMYYQNTYQTMPYGSSYGI PYSY--TAY-----------------------------GSS-DAKSQKTDNTVPFKTPSN EMTPVTIDLVKKQLKD-R------------------------------------------ ----------------------LDSMKELHKTNRQQHEKHLQSRVDSTRAIERLEGSSGG IGERYKFLQEMRGYVQDLLECFSEKVPLINELESAIHQLYKQRASRLVQRRQDDIKDESS EFSSHS-------------------NKALMAPNLDSFGRDRALYQEHAK-RRIAERE--- ---ARR-TRR-RQAREQTGKMADHLEGLSSDDEETSTDITNFNLEK--DRISKESSKVFE DVLESFYSIDCIKSQFEAWRSKYYTSYKDAYIGLCLPKLFNPLIRLQLLTWTPLE----- -------------------------------AKCRDFENMLWFESLLFYGCEERE--QEK DDVDVALLPTIVEKVILPKLTVIAENMWDPFSTT--------------QTSRMVGITLKL INGYPSVVNAENKN-----TQVYLKALLLRMRRTLDDDVFMPLYPKNVLENKNSGPYLFF QRQFWSSVKLLGNFLQWYGIFSNKTLQELSIDGLLNRYILMAFQNSEYGDDSIKKAQNVI NCFPKQWFMNLKGERTISQLENFCRYLVHLADTIYRNSIGCSDVEKRNARENIKQIVKLL ASVRALDHAMSVASEH----------------N------------VKEFKSLIEGK-- >ENSANAP00000030801 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------MF----- ------------------------------------------------------------ --------------------RKARRVNVRKRNDSEEEE-------RER------------ -------------------------------------------------------DEEQE ----------------------------------------PP------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------P--------------- ------------------------------------------------------------ -----------LL----------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------------PP ------------------------------------------------------------ ------------------------------------------------------------ ----------P-------------------GT---------------------------- ------------------------------------------------------------ ----------------GEEA-----GP--------------------------------- -----------------------------------GGS--------DRA----------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------P-------------------------------------------- ---------------GGESL---------------------------------------- ------------------------------------LGPGP-------------PPL--- ------------------------------------------------------------ ---SA-------------LTPGL------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------GAEAGGGFPGGAEPGNGLKPRKR PRENKE--VP-------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------RAS----------------- ------------------LLSF-QDE-EE-EN---------------------------- ---------------------------------------------------------E-- ------EVFKVKKSSYSKKIVKLLKKEYKE------------------------------ ----------------------DLEKSK-------------------------------- ------------------------------------------------------------ ---------------------IKTELN-----------S--------------------- -------------------SAESEQPLDKTGHVKDTNQEDGVIISEHGEDEMDMES---- EKEEE------------------------------------------------------K PKT-GGAFS--------------------------------------------------- -------NALSSLNVLRP-----------GEIPDAAFIHAARKKRQMARELGDFTP-HDN E-PGKGRLVR-ED--ENDA-SD-DEDDDEKRRIVFSVKEKSQRQKIAEE--I---GIEGS DDDALV-TGEQDEELSRWEQEQIRKGINIPQVQASQPAEV-NMYYQNTYQTMPYGSSYGI PYSY--TAY-----------------------------GSS-DAKSQKTDNTVPFKTPSN EMTPVTIDLVKKQLKD-R------------------------------------------ ----------------------LDSMKELHKTNRQQHEKHLQSRVDSTRAIERLEGSSGG IGERYKFLQEMRGYVQDLLECFSEKVPLINELESAIHQLYKQRASRLVQRRQDDIKDESS EFSSHS-------------------NKALMAPNLDSFGRDRALYQEHAK-RRIAERE--- ---ARR-TRR-RQAREQTGKMADHLEGLSSDDEETSTDITNFNLEK--DRISKESSKVFE DVLESFYSIDCIKSQFEAWRSKYYTSYKDAYIGLCLPKLFNPLIRLQLLTWTPLE----- -------------------------------AKCRDFENMLWFESLLFYGCEERE--QEK DDVDVALLPTIVEKVILPKLTVIAENMWDPFSTT--------------QTSRMVGITLKL INGYPSVVNAENKN-----TQVYLKALLLRMRRTLDDDVFMPLYPKNVLENKNSGPYLFF QRQFWSSVKLLGNFLQWYGIFSNKTLQELSIDGLLNRYILMAFQNSEYGDDSIKKAQNVI NCFPKQWFMNLKGERTISQLENFCRYLVHLADTIYRNSIGCSDVEKRNARENIKQIVKLL ASVRALDHAMSVASDH----------------N------------VKEFKSLIEGK-- >ENSCATP00000012241 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------MF----- ------------------------------------------------------------ --------------------RKARRVNVRKRNDSEEEE-------RER------------ -------------------------------------------------------DEEQE ----------------------------------------PP------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------P--------------- ------------------------------------------------------------ -----------LL----------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------------PP ------------------------------------------------------------ ------------------------------------------------------------ ----------P-------------------GT---------------------------- ------------------------------------------------------------ ----------------GEEA-----GP--------------------------------- -----------------------------------GGG--------DRA----------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------P-------------------------------------------- ---------------GGESL---------------------------------------- ------------------------------------LGPGP-------------PPP--- ------------------------------------------------------------ ---SA-------------LTPGL------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------GAEAGGCFPSGAEPGNGLKTRKR PRENKE--MP-------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------RAS----------------- ------------------LLSF-QDE-EE-EN---------------------------- ---------------------------------------------------------E-- ------EVFKVKKSSYSKKIVKLLKKEYKE------------------------------ ----------------------DLEKSK-------------------------------- ------------------------------------------------------------ ---------------------IKTELN-----------S--------------------- -------------------SAESEQPLDKTGHVKDTNQEDGVIISEHGEDEMDMES---- EKEEE------------------------------------------------------K PKT-GGAFS--------------------------------------------------- -------NALSSLNVLRP-----------GEIPDAAFIHAARKKRQMARELGDFTP-HDN E-PGKGRLVR-ED--ENDA-SD-DEDDDEKRRIVFSVKEKSQRQKIAEE--I---GIEGS DDDALV-TGEQDEELSRWEQEQIRKGINIPQVQASQPTEV-NMYYQNTYQTMPYSSSYGI PYSY--TAY-----------------------------GSS-DAKSQKTDNTVPFKTPSN EMTPVTIDLVKKQLKD-R------------------------------------------ ----------------------LDSMKELHKTNRQQHEKHLQSRVDSTRAIERLEGSSGG IGERYKFLQEMRGYVQDLLECFSEKVPLINELESAIHQLYKQRASRLVQRRQDDIKDESS EFSSHS-------------------NKALMAPNLDSFGRDRALYQEHAK-RRIAERE--- ---ARR-TRR-RQAREQTGKMADHLEGLSSDDEETSTDITNFNLEK--DRISKESSKVFE DVLESFYSIDCIKSQFEAWRSKYYTSYKDAYIGLCLPKLFNPLIRLQLLTWTPLE----- -------------------------------AKCRDFENMLWFESLLFYGCEERE--QEK DDVDVALLPTIVEKVILPKLTVIAENMWDPFSTT--------------QTSRMVGITLKL INGYPSVVNAENKN-----TQVYLKALLLRMRRTLDDDVFMPLYPKNVLENKNSGPYLFF QRQFWSSVKLLGNFLQWYGIFSNKTLQELSIDGLLNRYILMAFQNSEYGDDSIKKAQNVI NCFPKQWFMNLKGERTISQLENFCRYLVHLADTIYRNSIGCSDVEKRNARENIKQIVKLL ASVRALDHAMSVASDH----------------N------------VKEFKSLIEGK-- >ENSMMUP00000016131 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------MF----- ------------------------------------------------------------ --------------------RKARRVNVRKRNDSEEEE-------RER------------ -------------------------------------------------------DEEQE ----------------------------------------PP------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------P--------------- ------------------------------------------------------------ -----------LL----------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------------PP ------------------------------------------------------------ ------------------------------------------------------------ ----------P-------------------GT---------------------------- ------------------------------------------------------------ ----------------GEEA-----GP--------------------------------- -----------------------------------GGG--------DRA----------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------P-------------------------------------------- ---------------GGESL---------------------------------------- ------------------------------------LGPGP-------------PPP--- ------------------------------------------------------------ ---SA-------------LTPGL------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------GAEAGGCFPSGAEPGNGLKTRKR PRENKE--MP-------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------RAS----------------- ------------------LLSF-QDE-EE-EN---------------------------- ---------------------------------------------------------E-- ------EVFKVKKSSYSKKIVKLLKKEYKE------------------------------ ----------------------DLEKSK-------------------------------- ------------------------------------------------------------ ---------------------IKTELN-----------S--------------------- -------------------SAESEQPLDKTGHVKDTNQEDGVIISEHGEDEMDMES---- EKEEE------------------------------------------------------K PKT-GGAFS--------------------------------------------------- -------NALSSLNVLRP-----------GEIPDAAFIHAARKKRQMARELGDFTP-HDN E-PGKGRLVR-ED--ENDA-SD-DEDDDEKRRIVFSVKEKSQRQKIAEE--I---GIEGS DDDALV-TGEQDEELSRWEQEQIRKGINIPQVQASQPTEV-NMYYQNTYQTMPYSSSYGI PYSY--TAY-----------------------------GSS-DAKSQKTDNTVPFKTPSN EMTPVTIDLVKKQLKD-R------------------------------------------ ----------------------LDSMKELHKTNRQQHEKHLQSRVDSTRAIERLEGSSGG IGERYKFLQEMRGYVQDLLECFSEKVPLINELESAIHQLYKQRASRLVQRRQDDIKDESS EFSSHS-------------------NKALMAPNLDSFGRDRALYQEHAK-RRIAERE--- ---ARR-TRR-RQAREQTGKMADHLEGLSSDDEETSTDITNFNLEK--DRISKESSKVFE DVLESFYSIDCIKSQFEAWRSKYYTSYKDAYIGLCLPKLFNPLIRLQLLTWTPLE----- -------------------------------AKCRDFENMLWFESLLFYGCEERE--QEK DDVDVALLPTIVEKVILPKLTVIAENMWDPFSTT--------------QTSRMVGITLKL INGYPSVVNAENKN-----TQVYLKALLLRMRRTLDDDVFMPLYPKNVLENKNSGPYLFF QRQFWSSVKLLGNFLQWYGIFSNKTLQELSIDGLLNRYILMAFQNSEYGDDSIKKAQNVI NCFPKQWFMNLKGERTISQLENFCRYLVHLADTIYRNSIGCSDVEKRNARENIKQIVKLL ASVRALDHAMSVASDH----------------N------------VKEFKSLIEGK-- >ENSMNEP00000015733 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------MF----- ------------------------------------------------------------ --------------------RKARRVNVRKRNDSEEEE-------RER------------ -------------------------------------------------------DEEQE ----------------------------------------PP------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------P--------------- ------------------------------------------------------------ -----------LL----------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------------PP ------------------------------------------------------------ ------------------------------------------------------------ ----------P-------------------GT---------------------------- ------------------------------------------------------------ ----------------GEEA-----GP--------------------------------- -----------------------------------GGG--------DRA----------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------P-------------------------------------------- ---------------GGESL---------------------------------------- ------------------------------------LGPGP-------------PPP--- ------------------------------------------------------------ ---SA-------------LTPGL------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------GAEAGGCFPSGAEPGNGLKTRKR PRENKE--MP-------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------RAS----------------- ------------------LLSF-QDE-EE-EN---------------------------- ---------------------------------------------------------E-- ------EVFKVKKSSYSKKIVKLLKKEYKE------------------------------ ----------------------DLEKSK-------------------------------- ------------------------------------------------------------ ---------------------IKTELN-----------S--------------------- -------------------SAESEQPLDKTGHVKDTNQEDGVIISEHGEDEMDMES---- EKEEE------------------------------------------------------K PKT-GGAFS--------------------------------------------------- -------NALSSLNVLRP-----------GEIPDAAFIHAARKKRQMARELGDFTP-HDN E-PGKGRLVR-ED--ENDA-SD-DEDDDEKRRIVFSVKEKSQRQKIAEE--I---GIEGS DDDALV-TGEQDEELSRWEQEQIRKGINIPQVQASQPTEV-NMYYQNTYQTMPYSSSYGI PYSY--TAY-----------------------------GSS-DAKSQKTDNTVPFKTPSN EMTPVTIDLVKKQLKD-R------------------------------------------ ----------------------LDSMKELHKTNRQQHEKHLQSRVDSTRAIERLEGSSGG IGERYKFLQEMRGYVQDLLECFSEKVPLINELESAIHQLYKQRASRLVQRRQDDIKDESS EFSSHS-------------------NKALMAPNLDSFGRDRALYQEHAK-RRIAERE--- ---ARR-TRR-RQAREQTGKMADHLEGLSSDDEETSTDITNFNLEK--DRISKESSKVFE DVLESFYSIDCIKSQFEAWRSKYYTSYKDAYIGLCLPKLFNPLIRLQLLTWTPLE----- -------------------------------AKCRDFENMLWFESLLFYGCEERE--QEK DDVDVALLPTIVEKVILPKLTVIAENMWDPFSTT--------------QTSRMVGITLKL INGYPSVVNAENKN-----TQVYLKALLLRMRRTLDDDVFMPLYPKNVLENKNSGPYLFF QRQFWSSVKLLGNFLQWYGIFSNKTLQELSIDGLLNRYILMAFQNSEYGDDSIKKAQNVI NCFPKQWFMNLKGERTISQLENFCRYLVHLADTIYRNSIGCSDVEKRNARENIKQIVKLL ASVRALDHAMSVASDH----------------N------------VKEFKSLIEGK-- >ENSTGEP00000033993 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------MF----- ------------------------------------------------------------ --------------------RKARRVNVRKRNDSEEEE-------RER------------ -------------------------------------------------------DEEQE ----------------------------------------PP------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------P--------------- ------------------------------------------------------------ -----------LL----------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------------PP ------------------------------------------------------------ ------------------------------------------------------------ ----------P-------------------GT---------------------------- ------------------------------------------------------------ ----------------GEEA-----GP--------------------------------- -----------------------------------GGG--------DRA----------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------P-------------------------------------------- ---------------GGESL---------------------------------------- ------------------------------------LGPGP-------------PPP--- ------------------------------------------------------------ ---SA-------------LTPGL------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------GAEAGGCFPSGAEPGNGLKTRKR PRENKE--MP-------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------RAS----------------- ------------------LLSF-QDE-EE-EN---------------------------- ---------------------------------------------------------E-- ------EVFKVKKSSYSKKIVKLLKKEYKE------------------------------ ----------------------DLEKSK-------------------------------- ------------------------------------------------------------ ---------------------IKTELN-----------S--------------------- -------------------SAESEQPLDKTGHVKDTNQEDGVIISEHGEDEMDMES---- EKEEE------------------------------------------------------K PKT-GGAFS--------------------------------------------------- -------NALSSLNVLRP-----------GEIPDAAFIHAARKKRQMARELGDFTP-HDN E-PGKGRLVR-ED--ENDA-SD-DEDDDEKRRIVFSVKEKSQRQKIAEE--I---GIEGS DDDALV-TGEQDEELSRWEQEQIRKGINIPQVQASQPTEV-NMYYQNTYQTMPYSSSYGI PYSY--TAY-----------------------------GSS-DAKSQKTDNTVPFKTPSN EMTPVTIDLVKKQLKD-R------------------------------------------ ----------------------LDSMKELHKTNRQQHEKHLQSRVDSTRAIERLEGSSGG IGERYKFLQEMRGYVQDLLECFSEKVPLINELESAIHQLYKQRASRLVQRRQDDIKDESS EFSSHS-------------------NKALMAPNLDSFGRDRALYQEHAK-RRIAERE--- ---ARR-TRR-RQAREQTGKMADHLEGLSSDDEETSTDITNFNLEK--DRISKESSKVFE DVLESFYSIDCIKSQFEAWRSKYYTSYKDAYIGLCLPKLFNPLIRLQLLTWTPLE----- -------------------------------AKCRDFENMLWFESLLFYGCEERE--QEK DDVDVALLPTIVEKVILPKLTVIAENMWDPFSTT--------------QTSRMVGITLKL INGYPSVVNAENKN-----TQVYLKALLLRMRRTLDDDVFMPLYPKNVLENKNSGPYLFF QRQFWSSVKLLGNFLQWYGIFSNKTLQELSIDGLLNRYILMAFQNSEYGDDSIKKAQNVI NCFPKQWFMNLKGERTISQLENFCRYLVHLADTIYRNSIGCSDVEKRNARENIKQIVKLL ASVRALDHAMSVASDH----------------N------------VKEFKSLIEGK-- >ENSMLEP00000018556 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------MF----- ------------------------------------------------------------ --------------------RKARRVNVRKRNDSEEEE-------RER------------ -------------------------------------------------------DEEQE ----------------------------------------PP------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------P--------------- ------------------------------------------------------------ -----------LL----------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------------PP ------------------------------------------------------------ ------------------------------------------------------------ ----------P-------------------GT---------------------------- ------------------------------------------------------------ ----------------GEEA-----GP--------------------------------- -----------------------------------GGG--------DRA----------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------P-------------------------------------------- ---------------GGESL---------------------------------------- ------------------------------------LGPGP-------------PPP--- ------------------------------------------------------------ ---SA-------------LTPGL------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------GAEAGGCFPSGAEPGNGLKTRKR PRENKE--MP-------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------RAS----------------- ------------------LLSF-QDE-EE-EN---------------------------- ---------------------------------------------------------E-- ------EVFKVKKSSYSKKIVKLLKKEYKE------------------------------ ----------------------DLEKSK-------------------------------- ------------------------------------------------------------ ---------------------IKTELN-----------S--------------------- -------------------SAESEQPLDKTGHVKDTNQEDGVIISEHGEDEMDMES---- EKEEE------------------------------------------------------K PKT-GGAFS--------------------------------------------------- -------NALSSLNVLRP-----------GEIPDAAFIHAARKKRQMARELGDFTP-HDN E-PGKGRLVR-ED--ENDA-SD-DEDDDEKRRIVFSVKEKSQRQKIAEE--I---GIEGS DDDALV-TGEQDEELSRWEQEQIRKGINIPQVQASQPTEV-NMYYQNTYQTMPYSSSYGI PYSY--TAY-----------------------------GSS-DAKSQKTDNTVPFKTPSN EMTPVTIDLVKKQLKD-R------------------------------------------ ----------------------LDSMKELHKTNRQQHEKHLQSRVDSTRAIERLEGSSGG IGERYKFLQEMRGYVQDLLECFSEKVPLINELESAIHQLYKQRASRLVQRRQDDIKDESS EFSSHS-------------------NKALMAPNLDSFGRDRALYQEHAK-RRIAERE--- ---ARR-TRR-RQAREQTGKMADHLEGLSSDDEETSTDITNFNLEK--DRISKESSKVFE DVLESFYSIDCIKSQFEAWRSKYYTSYKDAYIGLCLPKLFNPLIRLQLLTWTPLE----- -------------------------------AKCRDFENMLWFESLLFYGCEERE--QEK DDVDVALLPTIVEKVILPKLTVIAENMWDPFSTT--------------QTSRMVGITLKL INGYPSVVNAENKN-----TQVYLKALLLRMRRTLDDDVFMPLYPKNVLENKNSGPYLFF QRQFWSSVKLLGNFLQWYGIFSNKTLQELSIDGLLNRYILMAFQNSEYGDDSIKKAQNVI NCFPKQWFMNLKGERTISQLENFCRYLVHLADTIYRNSIGCSDVEKRNARENIKQIVKLL ASVRALDHAMSVASDH----------------N------------VKEFKSLIEGK-- >ENSMFAP00000032678 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------MF----- ------------------------------------------------------------ --------------------RKARRVNVRKRNDSEEEE-------RER------------ -------------------------------------------------------DEEQE ----------------------------------------PP------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------P--------------- ------------------------------------------------------------ -----------LL----------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------------PP ------------------------------------------------------------ ------------------------------------------------------------ ----------P-------------------GT---------------------------- ------------------------------------------------------------ ----------------GEEA-----GP--------------------------------- -----------------------------------GGG--------DRA----------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------P-------------------------------------------- ---------------GGESL---------------------------------------- ------------------------------------LGPGP-------------PPP--- ------------------------------------------------------------ ---SA-------------LTPGL------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------GAEAGGCFPSGAEPGNGLKTRKR PRENKE--MP-------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------RAS----------------- ------------------LLSF-QDE-EE-EN---------------------------- ---------------------------------------------------------E-- ------EVFKVKKSSYSKKIVKLLKKEYKE------------------------------ ----------------------DLEKSK-------------------------------- ------------------------------------------------------------ ---------------------IKTELN-----------S--------------------- -------------------SAESEQPLDKTGHVKDTNQEDGVIISEHGEDEMDMES---- EKEEE------------------------------------------------------K PKT-GGAFS--------------------------------------------------- -------NALSSLNVLRP-----------GEIPDAAFIHAARKKRQMARELGDFTP-HDN E-PGKGRLVR-ED--ENDA-SD-DEDDDEKRRIVFSVKEKSQRQKIAEE--I---GIEGS DDDALV-TGEQDEELSRWEQEQIRKGINIPQVQASQPTEV-NMYYQNTYQTMPYSSSYGI PYSY--TAY-----------------------------GSS-DAKSQKTDNTVPFKTPSN EMTPVTIDLVKKQLKD-R------------------------------------------ ----------------------LDSMKELHKTNRQQHEKHLQSRVDSTRAIERLEGSSGG IGERYKFLQEMRGYVQDLLECFSEKVPLINELESAIHQLYKQRASRLVQRRQDDIKDESS EFSSHS-------------------NKALMAPNLDSFGRDRALYQEHAK-RRIAERE--- ---ARR-TRR-RQAREQTGKMADHLEGLSSDDEETSTDITNFNLEK--DRISKESSKVFE DVLESFYSIDCIKSQFEAWRSKYYTSYKDAYIGLCLPKLFNPLIRLQLLTWTPLE----- -------------------------------AKCRDFENMLWFESLLFYGCEERE--QEK DDVDVALLPTIVEKVILPKLTVIAENMWDPFSTT--------------QTSRMVGITLKL INGYPSVVNAENKN-----TQVYLKALLLRMRRTLDDDVFMPLYPKNVLENKNSGPYLFF QRQFWSSVKLLGNFLQWYGIFSNKTLQELSIDGLLNRYILMAFQNSEYGDDSIKKAQNVI NCFPKQWFMNLKGERTISQLENFCRYLVHLADTIYRNSIGCSDVEKRNARENIKQIVKLL ASVRALDHAMSVASDH----------------N------------VKEFKSLIEGK-- >ENSPANP00000010252 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------MF----- ------------------------------------------------------------ --------------------RKARRVNVRKRNDSEEEE-------RER------------ -------------------------------------------------------DEEQE ----------------------------------------PP------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------P--------------- ------------------------------------------------------------ -----------LL----------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------------PP ------------------------------------------------------------ ------------------------------------------------------------ ----------P-------------------GT---------------------------- ------------------------------------------------------------ ----------------GEEA-----GP--------------------------------- -----------------------------------GGG--------DRA----------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------P-------------------------------------------- ---------------GGESL---------------------------------------- ------------------------------------LGPGP-------------PPP--- ------------------------------------------------------------ ---SA-------------LTPGL------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------GAEAGGCFPSGAEPGNGLKTRKR PRENKE--MP-------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------RAS----------------- ------------------LLSF-QDE-EE-EN---------------------------- ---------------------------------------------------------E-- ------EVFKVKKSSYSKKIVKLLKKEYKE------------------------------ ----------------------DLEKSK-------------------------------- ------------------------------------------------------------ ---------------------IKTELN-----------S--------------------- -------------------SAESEQPLDKTGHVKDTNQEDGVIISEHGEDEMDMES---- EKEEE------------------------------------------------------K PKT-GGAFS--------------------------------------------------- -------NALSSLNVLRP-----------GEIPDAAFIHAARKKRQMARELGDFTP-HDN E-PGKGRLVR-ED--ENDA-SD-DEDDDEKRRIVFSVKEKSQRQKIAEE--I---GIEGS DDDALV-TGEQDEELSRWEQEQIRKGINIPQVQASQPTEV-NMYYQNTYQTMPYSSSYGI PYSY--TAY-----------------------------GSS-DAKSQKTDNTVPFKTPSN EMTPVTIDLVKKQLKD-R------------------------------------------ ----------------------LDSMKELHKTNRQQHEKHLQSRVDSTRAIERLEGSSGG IGERYKFLQEMRGYVQDLLECFSEKVPLINELESAIHQLYKQRASRLVQRRQDDIKDESS EFSSHS-------------------NKALMAPNLDSFGRDRALYQEHAK-RRIAERE--- ---ARR-TRR-RQAREQTGKMADHLEGLSSDDEETSTDITNFNLEK--DRISKESSKVFE DVLESFYSIDCIKSQFEAWRSKYYTSYKDAYIGLCLPKLFNPLIRLQLLTWTPLE----- -------------------------------AKCRDFENMLWFESLLFYGCEERE--QEK DDVDVALLPTIVEKVILPKLTVIAENMWDPFSTT--------------QTSRMVGITLKL INGYPSVVNAENKN-----TQVYLKALLLRMRRTLDDDVFMPLYPKNVLENKNSGPYLFF QRQFWSSVKLLGNFLQWYGIFSNKTLQELSIDGLLNRYILMAFQNSEYGDDSIKKAQNVI NCFPKQWFMNLKGERTISQLENFCRYLVHLADTIYRNSIGCSDVEKRNARENIKQIVKLL ASVRALDHAMSVASDH----------------N------------VKEFKSLIEGK-- >ENSCSAP00000005914 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------MF----- ------------------------------------------------------------ --------------------RKARRVNVRKRNDSEEEE-------RER------------ -------------------------------------------------------DEEQE ----------------------------------------PP------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------P--------------- ------------------------------------------------------------ -----------LL----------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------------PP ------------------------------------------------------------ ------------------------------------------------------------ ----------P-------------------GT---------------------------- ------------------------------------------------------------ ----------------GEEA-----GP--------------------------------- -----------------------------------GGG--------DRA----------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------P-------------------------------------------- ---------------GGESL---------------------------------------- ------------------------------------LGPGP-------------PPP--- ------------------------------------------------------------ ---SA-------------LTPGL------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------GAEAGGCFPSGAEPGNGLKTRKR PRENKE--MP-------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------RAS----------------- ------------------LLSF-QDE-EE-EN---------------------------- ---------------------------------------------------------E-- ------EVFKVKKSSYSKKIVKLLKKEYKE------------------------------ ----------------------DLEKSK-------------------------------- ------------------------------------------------------------ ---------------------IKTELN-----------S--------------------- -------------------SAESEQPLDKTGHIKDTNQEDGVIISEHGEDEMDMES---- EKEEE------------------------------------------------------K PKT-GGAFS--------------------------------------------------- -------NALSSLNVLRP-----------GEIPDAAFIHAARKKRQMARELGDFTP-HDN E-PGKGRLVR-ED--ENDA-SD-DEDDDEKRRIVFSVKEKSQRQKIAEE--I---GIEGS DDDALV-TGEQDEELSRWEQEQIRKGINIPQVQASQPTEV-NMYYQNTYQTMPYSSSYGI PYSY--TAY-----------------------------GSS-DAKSQKTDNTVPFKTPSN EMTPVTIDLVKKQLKD-R------------------------------------------ ----------------------LDSMKELHKTNRQQHEKHLQSRVDSTRAIERLEGSSGG IGERYKFLQEMRGYVQDLLECFSEKVPLINELESAIHQLYKQRASRLVQRRQDDIKDESS EFSSHS-------------------NKALMAPNLDSFGRDRALYQEHAK-RRIAERE--- ---ARR-TRR-RQAREQTGKMADHLEGLSSDDEETSTDITNFNLEK--DRISKESSKVFE DVLESFYSIDCIKSQFEAWRSKYYTSYKDAYIGLCLPKLFNPLIRLQLLTWTPLE----- -------------------------------AKCRDFENMLWFESLLFYGCEERE--QEK DDVDVALLPTIVEKVILPKLTVIAENMWDPFSTT--------------QTSRMVGITLKL INGYPSVVNAENKN-----TQVYLKALLLRMRRTLDDDVFMPLYPKNVLENKNSGPYLFF QRQFWSSVKLLGNFLQWYGIFSNKTLQELSIDGLLNRYILMAFQNSEYGDDSIKKAQNVI NCFPKQWFMNLKGERTISQLENFCRYLVHLADTIYRNSIGCSDVEKRNARENIKQIVKLL ASVRALDHAMSVASDH----------------N------------VKEFKSLIEGK-- >ENSRROP00000001103 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------MF----- ------------------------------------------------------------ --------------------RKARRVNVRKRNDSEEEE-------RER------------ -------------------------------------------------------DEEQE ----------------------------------------PP------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------P--------------- ------------------------------------------------------------ -----------LL----------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------------PP ------------------------------------------------------------ ------------------------------------------------------------ ----------P-------------------GT---------------------------- ------------------------------------------------------------ ----------------GEEA-----GPG-------------------------------- -----------------------------------GGG--------DRA----------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------P-------------------------------------------- ---------------GGESL---------------------------------------- ------------------------------------LGPGP-------------PPP--- ------------------------------------------------------------ ---SA-------------LTPGL------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------GAEAGGCFPSGAEPGNGLKTRKR PRENKE--MP-------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------RAS----------------- ------------------LLSF-QDE-EE-EN---------------------------- ---------------------------------------------------------E-- ------EVFKVKKSSYSKKIVKLLKKEYKE------------------------------ ----------------------DLEKSK-------------------------------- ------------------------------------------------------------ ---------------------IKTELN-----------S--------------------- -------------------SAESEQPLDKAGHVKDTNQEDGVIISEHGEDEMDMES---- EKEEE------------------------------------------------------K PKT-GGAFS--------------------------------------------------- -------NALSSLNVLRP-----------GEIPDAAFIHAARKKRQMARELGDFTP-HDN E-PGKGRLVR-ED--ENDA-SD-DEDDDEKRRIVFSVKEKSQRQKIAEE--I---GIEGS DDDALV-TGEQDEELSRWEQEQIRKGINIPQVQASQPTEV-NMYYQNTYQTMPYSSSYGI PYSY--TAY-----------------------------GSS-DAKSQKTDNTVPFKTPSN EMTPVTIDLVKKQLKD-R------------------------------------------ ----------------------LDSMKELHKTNRQQHEKHLQSRVDSTRAIERLEGSSGG IGERYKFLQEMRGYVQDLLECFSEKVPLINELESAIHQLYKQRASRLVQRRQDDIKDESS EFSSHS-------------------NKALMAPNLDSFGRDRALYQEHAK-RRIAERE--- ---ARR-TRR-RQAREQTGKMADHLEGLSSDDEETSTDITNFNLEK--DRISKESSKVFE DVLESFYSIDCIKSQFEAWRSKYYTSYKDAYIGLCLPKLFNPLIRLQLLTWTPLE----- -------------------------------AKCRDFENMLWFESLLFYGCEERE--QEK DDVDVALLPTIVEKVILPKLTVIAENMWDPFSTT--------------QTSRMVGITLKL INGYPSVVNAENKN-----TQVYLKALLLRMRRTLDDDVFMPLYPKNVLENKNSGPYLFF QRQFWSSVKLLGNFLQWYGIFSNKTLQELSIDGLLNRYILMAFQNSEYGDDSIKKAQNVI NCFPKQWFMNLKGERTISQLENFCRYLVHLADTIYRNSIGCSDVEKRNARENIKQIVKLL ASVRALDHAMSVASDH----------------N------------VKEFKSLIEGK-- >ENSCANP00000033996 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------MF----- ------------------------------------------------------------ --------------------RKARRVNVRKRNDSEEEE-------RER------------ -------------------------------------------------------DEEQE ----------------------------------------PP------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------P--------------- ------------------------------------------------------------ -----------LL----------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------------PP ------------------------------------------------------------ ------------------------------------------------------------ ----------P-------------------GTXXXXXXXXXXXXXXXX---------XXX -------------------------XXX-------------------------------- XXXXXXX-------XX-------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------GL------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------GAEAGGCFPSGAEPGNGLKTRKR PRENKE--MP-------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------RAS----------------- ------------------LLSF-QDE-EE-EN---------------------------- ---------------------------------------------------------E-- ------EVFKVKKSSYSKKIVKLLKKEYKE------------------------------ ----------------------DLEKSK-------------------------------- ------------------------------------------------------------ ---------------------IKTELN-----------S--------------------- -------------------SAESEQPLDKAGHVKDTNQEDGVIISEHGEDEMDMES---- EKEEE------------------------------------------------------K PKT-GGAFS--------------------------------------------------- -------NALSSLNVLRP-----------GEIPDAAFIHAARKKRQMARELGDFTP-HDN E-PGKGRLVR-ED--ENDA-SD-DEDDDEKRRIVFSVKEKSQRQKIAEE--I---GIEGS DDDALV-TGEQDEELSRWEQEQIRKGINIPQVQASQPTEV-NMYYQNTYQTMPYSSSYGI PYSY--TAY-----------------------------GSS-DAKSQKTDNTVPFKTPSN EMTPVTIDLVKKQLKD-R------------------------------------------ ----------------------LDSMKELHKTNRQQHEKHLQSRVDSTRAIERLEGSSGG IGERYKFLQEMRGYVQDLLECFSEKVPLINELESAIHQLYKQRASRLVQRRQDDIKDESS EFSSHS-------------------NKALMAPNLDSFGRDRALYQEHAK-RRIAERE--- ---ARR-TRR-RQAREQTGKMADHLEGLSSDDEETSTDITNFNLEK--DRISKESSKVFE DVLESFYSIDCIKSQFEAWRSKYYTSYKDAYIGLCLPKLFNPLIRLQLLTWTPLE----- -------------------------------AKCRDFENMLWFESLLFYGCEERE--QEK DDVDVALLPTIVEKVILPKLTVIAENMWDPFSTT--------------QTSRMVGITLKL INGYPSVVNAENKN-----TQVYLKALLLRMRRTLDDDVFMPLYPKNVLENKNSGPYLFF QRQFWSSVKLLGNFLQWYGIFSNKTLQELSIDGLLNRYILMAFQNSEYGDDSIKKAQNVI NCFPKQWFMNLKGERTISQLENFCRYLVHLADTIYRNSIGCSDVEKRNARENIKQIVKLL ASVRALDHAMSVASDH----------------N------------VKEFKSLIEGK-- >ENSPTEP00000009733 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------MF----- ------------------------------------------------------------ --------------------RKARRVNVRKRNDSEEEE-------RER------------ -------------------------------------------------------DEEQE ----------------------------------------PP------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------P--------------- ------------------------------------------------------------ -----------LL----------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------------PP ------------------------------------------------------------ ------------------------------------------------------------ ----------P-------------------GT---------------------------- ------------------------------------------------------------ ----------------GEEA-----GP--------------------------------- -----------------------------------GGGG----GGSDRA----------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------P-------------------------------------------- ---------------GGESL---------------------------------------- ------------------------------------LGPGP-------------QPP--- ------------------------------------------------------------ ---SA-------------LTPGL------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------GAEAGGCFPSGAEPGNGLKTRKR PRENKE--MP-------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------RAS----------------- ------------------LLSF-QDE-EE-EN---------------------------- ---------------------------------------------------------E-- ------EVFKVKKSSYSKKIVKLLKKEYKE------------------------------ ----------------------DLEKSK-------------------------------- ------------------------------------------------------------ ---------------------IKTELN-----------S--------------------- -------------------SAESEQPLDKAGHVKDTNQEDGVIISEHGEDEMDMES---- EKEEE------------------------------------------------------K PKT-GGAFS--------------------------------------------------- -------NALSSLNVLRP-----------GEIPDAAFIHAARKKRQMARELGDFTP-HDN E-PGKGRLVR-ED--ENDA-SD-DEDDDEKRRIVFSVKEKSQRQKIAEE--I---GIEGS DDDALV-TGEQDEELSRWEQEQIRKGINIPQVQASQPTEV-NMYYQNTYQTMPYSSSYGI PYSY--TAY-----------------------------GSS-DAKSQKTDNTVPFKTPSN EMTPVTIDLVKKQLKD-R------------------------------------------ ----------------------LDSMKELHKTNRQQHEKHLQSRVDSTRAIERLEGSSGG IGERYKFLQEMRGYVQDLLECFSEKVPLINELESAIHQLYKQRASRLVQRRQDDIKDESS EFSSHS-------------------NKALMAPNLDSFGRDRALYQEHAK-RRIAERE--- ---ARR-TRR-RQAREQTGKMADHLEGLSSDDEETSTDITNFNLEK--DRISKESSKVFE DVLESFYSIDCIKSQFEAWRSKYYTSYKDAYIGLCLPKLFNPLIRLQLLTWTPLE----- -------------------------------AKCRDFENMLWFESLLFYGCEERE--QEK DDVDVALLPTIVEKVILPKLTVIAENMWDPFSTT--------------QTSRMVGITLKL INGYPSVVNAENKN-----TQVYLKALLLRMRRTLDDDVFMPLYPKNVLENKNSGPYLFF QRQFWSSVKLLGNFLQWYGIFSNKTLQELSIDGLLNRYILMAFQNSEYGDDSIKKAQNVI NCFPKQWFMNLKGERTISQLENFCRYLVHLADTIYRNSIGCSDVEKRNARENIKQIVKLL ASVRALDHAMSVASDH----------------N------------VKEVKSLIEGK-- >ENSNLEP00000004596 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------MF----- ------------------------------------------------------------ --------------------RKARRVNVRKRNDSEEEE-------RER------------ -------------------------------------------------------DEEQE ----------------------------------------PP------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------P--------------- ------------------------------------------------------------ -----------LL----------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------------PP ------------------------------------------------------------ ------------------------------------------------------------ ----------P-------------------AT---------------------------- ------------------------------------------------------------ ----------------GEEA-----GP--------------------------------- -----------------------------------GGG--------DRA----------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------P-------------------------------------------- ---------------GGESL---------------------------------------- ------------------------------------LGPGP-------------PPP--- ------------------------------------------------------------ ---SG-------------LTPGL------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------GAEAGGGFSGGAEPGNGLKPRKR PRENKE--VP-------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------RAS----------------- ------------------LLSF-QDE-EE-EN---------------------------- ---------------------------------------------------------E-- ------EVFKVKKSSYSKKIVKLLKKEYKE------------------------------ ----------------------DLEKSK-------------------------------- ------------------------------------------------------------ ---------------------IKTELN-----------S--------------------- -------------------SAESEQPLDKTGQVKDTNQEDGVIISEHGEDEMDMES---- EKEEE------------------------------------------------------K PKT-GGAFS--------------------------------------------------- -------NALSSLNVLRP-----------GEIPDAAFIHAARKKRQMARELGDFTP-HDN E-PGKGRLVR-ED--ENDA-SD-DEDDDEKRRIVFSVKEKSQRQKIAEE--I---GIEGS DDDALV-TGEQDEELSRWEQEQIRKGINIPQVQASQPAEV-NMYYQNTYQTMPYGSSYGI PYSY--TAY-----------------------------GSS-DAKSQKTDNTVPFKTPSN EMTPVTIDLVKKQLKD-R------------------------------------------ ----------------------LDSMKELHKTNRQQHEKHLQSRVDSTRAIERLEGSSGG IGERYKFLQEMRGYVQDLLECFSEKVPLINELESAIHQLYKQRASRLVQRRQDDIKDESS EFSSHS-------------------NKALMAPNLDSFGRDRALYQEHAK-RRIAERE--- ---ARR-TRR-RQAREQTGKMADHLEGLSSDDEETSTDITNFNLEK--DRISKESSKVFE DVLESFYSIDCIKSQFEAWRSKYYFSYKDAYIGLCLPKLFNPLILLQLLTWTPLE----- -------------------------------AKCRDFENMLWFESLLFYGCEERE--QEK DDVDVALLPTIVEKVILPKLTVIAENMWDPFSTT--------------QTSRMVGITLKL INGYPSVVNAENKN-----TQVYLKALLLRMRRTLDDDVFMPLYPKNVLENKNSGPYLFF QRQFWSSVKLLGNFLQWYGIFSNKTLQELSIDGLLNRYILMAFQNSEYGDDSIKKAQNVI NCFPKQWFMNLKGERTISQLENFCRYLVHLADTIYRNSIGCSDVEKRNARENIKQIVKLL ASVRALDHAMSVASDH----------------N------------VKEFKSLIEGK-- >ENSOGAP00000002985 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------MF----- ------------------------------------------------------------ --------------------RKARRVNVRKRNDSEEEE-------RER------------ -------------------------------------------------------DEEQE ----------------------------------------VP------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------P--------------- ------------------------------------------------------------ -----------LL----------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------------P ------------------------------------------------------------ ------------------------------------------------------------ ----------P-------------------GT---------------------------- ------------------------------------------------------------ ----------------GEEQG---LGG--------------------------------- -----------------------------------GGG--------DRP----------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------P-------------------------------------------- ---------------GGEAL---------------------------------------- ------------------------------------LGPGL-------------PPP--- ------------------------------------------------------------ ---SA-------------LTPGL------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------GAEAGGGFPGGTEPGNGLKPRKR PRENKE--VP-------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------RAS----------------- ------------------LLSF-QDE-EE-EN---------------------------- ---------------------------------------------------------E-- ------EVFKVKKSSYSKKIVKLLKKEYKE------------------------------ ----------------------DLEKSK-------------------------------- ------------------------------------------------------------ ---------------------IKTELN-----------S--------------------- -------------------SADNEQPLDKTGHVKDTNQEDGVIISEHGEDEMDMES---- EKEEE------------------------------------------------------K PKA-GGAFS--------------------------------------------------- -------NALSSLNVLRP-----------GEIPDAAFIHAARKKRQMARELGDFTP-HDN E-PGKGRLVR-ED--ENDA-SD-DEDDDEKRRIVFSVKEKSQRQKIAEE--I---GIEGS DDDALV-TGEQDEELSRWEQEQIRKGINIPQVQASQPAEV-NMYYPNTYQTMPYGSSYGI PYSY--TAY-----------------------------GSS-DAKSQKTDNTVPFKTPSN EMTPVTIDLVKKQLKD-R------------------------------------------ ----------------------LDSMKELHKTNRQQHEKHLQSRVDSTRAIERLEGSSGG IGERYKFLQEMRGYVQDLLECFSEKVPLINELESAIHQLYKQRASRLVQRRQDDIKDESS EFSSHS-------------------NKALMAPNLDSFGRDRALYQEHAK-RRIAERE--- ---ARR-TRR-RQAREQTGKMADHLEGLSSDDEETSTDITNFNLEK--DRISKESSKVFE DVLESFYSIDCIKSQFEAWRSKYYMSYKDAYIGLCLPKLFNPLIRLQLLTWTPLE----- -------------------------------AKCRDFENMLWFESLLFYGCEERE--QEK DDVDVALLPTIVEKVILPKLTVIAENMWDPFSTT--------------QTSRMVGITLKL INGYPSVVNAENKN-----TQVYLKALLLRMRRTLDDDVFMPLYPKNVLENKNSGPYLFF QRQFWSSVKLLGNFLQWYGIFSNKTLQELSIDGLLNRYILMAFQNSEYGDDSIKKAQNVI NCFPKQWFMNLKGERTISQLENFCRYLVHLADTIYRNSIGCSDVEKRNARENIKQIVKLL ASVRALDHAMAVASDH----------------N------------VKEFKSLIEGK-- >ENSSTOP00000012612 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------MF----- ------------------------------------------------------------ --------------------RKARRVN--------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------GFPGGAEPGNGLKPRKR PRENKE--VP-------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------RAS----------------- ------------------LLSF-QDE-EE-EN---------------------------- ---------------------------------------------------------E-- ------EVFKVKKSSYSKKIVKLLKKEYKE------------------------------ ----------------------DLEKSK-------------------------------- ------------------------------------------------------------ ---------------------IKTELN-----------S--------------------- -------------------SADNEQPLDKTGHVKDTNPEDGVIISEHGEDEMDMES---- EKEEE------------------------------------------------------K PKA-GGTFS--------------------------------------------------- -------NALSSLNVLRP-----------GEIPDAAFIHAARKKRQMARELGDFTP-HDN E-PGKGRLVR-ED--ENDA-SD-DEDDDEKRRIVFSVKEKSQRQKIAEE--I---GIEGS DDDALV-TGEQDEELSRWEQEQIRKGINIPQVQASQPTEV-NMYYQNTYQAMPYGSSYGI PYSY--TTY-----------------------------GSS-DAKSQKTDNSAPFKTPSN EMTPVTIDLVKKQLKD-R------------------------------------------ ----------------------LDSMKELHKTNRQQHEKHLQSRVDSTRAIERLEGSSGG IGERYKFLQEMRGYVQDLLECFSEKVPLINELESAIHQLYKQRASRLVQRRQDDIKDESS EFSSHS-------------------NKALMAPNLDSFGRDRALYQEHAK-RRIAERE--- ---ARR-TRR-RQAREQTGKMADHLEGLSSDDEETSTDITNFNLEK--DRISKESSKVFE DVLESFYSIDCIKSQFEAWRSKYYMSYKDAYIGLCLPKLFNPLIRLQLLTWTPLE----- -------------------------------AKCRDFENMLWFESLLFYGCEERE--QEK DDVDVALLPTIVEKVILPKLTVIAENMWDPFSTT--------------QTSRMVGITLKL INGYPSVVNAENKN-----TQVYLKALLLRMRRTLDDDVFMPLYPKNVLENKNSGPYLFF QRQFWSSVKLLGNFLQWYGIFSNKTLQELSIDGLLNRYILMAFQNSEYGDDSIKKAQNVI NCFPKQWFMNLKGERTISQLENFCRYLVHLADTIYRNSIGCSDVDKRNARENIKQIVKLL ASIRALDHAMSVASDH----------------N------------VKEFKSLIEGK-- >ENSUPAP00010002295 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------MF----- ------------------------------------------------------------ --------------------RKARRVNVRKRNDSEEEE-------RER------------ -------------------------------------------------------DEEQE ----------------------------------------PP------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------P--------------- ------------------------------------------------------------ -----------LL----------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------------PP ------------------------------------------------------------ ------------------------------------------------------------ ----------P-------------------AT---------------------------- ------------------------------------------------------------ ----------------GEEP-----GP--------------------------------- -----------------------------------GGG--------ERA----------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------P-------------------------------------------- ---------------GGESL---------------------------------------- ------------------------------------LSPGL-------------PPP--- ------------------------------------------------------------ ---SA-------------LTPSL------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------GAEAGGGFPGGAEPGNGLKPRKR PRENKE--VP-------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------RAS----------------- ------------------LLSF-QDE-EE-EN---------------------------- ---------------------------------------------------------E-- ------EVFKVKKSSYSKKIVKLLKKEYKE------------------------------ ----------------------DLEKSK-------------------------------- ------------------------------------------------------------ ---------------------IKTELN-----------S--------------------- -------------------SADNEQPLDKTGHVKDINPEDGVIISEHGEDEMDMES---- EKEEE------------------------------------------------------K PKA-GGTFS--------------------------------------------------- -------NALSSLNVLRP-----------GEIPDAAFIHAARKKRQMARELGDFTP-HDN E-PGKGRLVR-ED--ENDA-SD-DEDDDEKRRIVFSVKEKSQRQKIAEE--I---GIEGS DDDALV-TGEQDEELSRWEQEQIRKGINIPQVQASQPTEV-NMYYQNTYQAMPYGSSYGI PYSY--TAY-----------------------------GSS-DAKSQKTDNSAPFKTPSN EMTPVTIDLVKKQLKD-R------------------------------------------ ----------------------LDSMKELHKTNRQQHEKHLQSRVDSTRAIERLEGSSGG IGERYKFLQEMRGYVQDLLECFSEKVPLINELESAIHQLYKQRASRLVQRRQDDIKDESS EFSSHS-------------------NKALMAPNLDSFGRDRALYQEHAK-RRIAERE--- ---ARR-TRR-RQAREQTGKMADHLEGLSSDDEETSTDITNFNLEK--DRISKESSKVFE DVLESFYSIDCIKSQFEAWRSKYYMSYKDAYIGLCLPKLFNPLIRLQLLTWTPLE----- -------------------------------AKCRDFENMLWFESLLFYGCEERE--QEK DDVDVALLPTIVEKVILPKLTVIAENMWDPFSTT--------------QTSRMVGITLKL INGYPSVVNAENKN-----TQVYLKALLLRMRRTLDDDVFMPLYPKNVLENKNSGPYLFF QRQFWSSVKLLGNFLQWYGIFSNKTLQELSIDGLLNRYILMAFQNSEYGDDSIKKAQNVI NCFPKQWFMNLKGERTISQLENFCRYLVHLADTIYRNSIGCSDVDKRNARENIKQIVKLL ASIRALDHAMSVASDH----------------N------------VKEFKSLIEGK-- >ENSMMMP00000000789 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------MF----- ------------------------------------------------------------ --------------------RKARRVNVRKRNDSEEEE-------RER------------ -------------------------------------------------------DEEQE ----------------------------------------PP------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------P--------------- ------------------------------------------------------------ -----------LL----------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------------PP ------------------------------------------------------------ ------------------------------------------------------------ ----------P-------------------AT---------------------------- ------------------------------------------------------------ ----------------GEEP-----GP--------------------------------- -----------------------------------GGG--------ERA----------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------P-------------------------------------------- ---------------GGESLXXXX------------------------------------ ----------XXX----------------------X------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --ENKE--VP-------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------RAS----------------- ------------------LLSF-QDE-EE-EN---------------------------- ---------------------------------------------------------E-- ------EVFKVKKSSYSKKIVKLLKKEYKE------------------------------ ----------------------DLEKSK-------------------------------- ------------------------------------------------------------ ---------------------IKTELN-----------S--------------------- -------------------SADNEQPLDKTGHVKDTNPEDGVIISEHGEDEMDMES---- EKEEE------------------------------------------------------K PKA-GGTFS--------------------------------------------------- -------NALSSLNVLRP-----------GEIPDAAFIHAARKKRQMARELGDFTP-HDN E-PGKGRLVR-ED--ENDA-SD-DEDDDEKRRIVFSVKEKSQRQKIAEE--I---GIEGS DDDALV-TGEQDEELSRWEQEQIRKGINIPQVQASQPTEV-NMYYQNTYQAMPYGSSYGI PYSY--TAY-----------------------------GSS-DAKSQKTDNSAPFKTPSN EMTPVTIDLVKKQLKD-R------------------------------------------ ----------------------LDSMKELHKTNRQQHEKHLQSRVDSTRAIERLEGSSGG IGERYKFLQEMRGYVQDLLECFSEKVPLINELESAIHQLYKQRASRLVQRRQDDIKDESS EFSSHS-------------------NKALMAPNLDSFGRDRALYQEHAK-RRIAERE--- ---ARR-TRR-RQAREQTGKMADHLEGLSSDDEETSTDITNFNLEK--DRISKESSKVFE DVLESFYSIDCIKSQFEAWRSKYYMSYKDAYIGLCLPKLFNPLIRLQLLTWTPLE----- -------------------------------AKCRDFENMLWFESLLFYGCEERE--QEK DDVDVALLPTIVEKVILPKLTVIAENMWDPFSTT--------------QTSRMVGITLKL INGYPSVVNAENKN-----TQVYLKALLLRMRRTLDDDVFMPLYPKNVLENKNSGPYLFF QRQFWSSVKLLGNFLQWYGIFSNKTLQELSIDGLLNRYILMAFQNSEYGDDSIKKAQNVI SCFPKQWFMNLKGERTISQLENFCRYLVHLADTIYRNSIGCSDVDKRNARENIKQIVKLL ASIRALDHAMSVASDH----------------N------------VKEFKSLIEGK-- >ENSSDAP00000010431 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------MF----- ------------------------------------------------------------ --------------------RKARRVNVRKRNDSEEEE-------RE------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------------EPGNGLKPRKR PRENKE--EP-------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------RAS----------------- ------------------LLSF-QDE-EE-EN---------------------------- ---------------------------------------------------------E-- ------EVFKVKKSSYSKKIVKLLKKEYKE------------------------------ ----------------------DLEKSK-------------------------------- ------------------------------------------------------------ ---------------------IKTELN-----------S--------------------- -------------------SADNEQPLDKTGHVKDTNPEDGIIISEHGEDEMDMES---- EKEEE------------------------------------------------------K PKT-GGTFS--------------------------------------------------- -------NALSSLNVLRP-----------GEIPDAAFIHAARKKRQMARELGDFTP-HDN E-PGKGRLVR-ED--ENDA-SD-DEDDDEKRRIVFSVKEKSQRQKIAEE--I---GIEGS DDDALV-TGEQDEELSRWEQEQIRKGINIPQVQASQPTEV-NMYYQNTYQAMPYGSSYGI PYSY--TAY-----------------------------GSS-DAKSQKTDNSAPFKTPSN EMTPVTIDLVKKQLKD-R------------------------------------------ ----------------------LDSMKELHKTNRQQHEKHLQSRVDSTRAIERLEGSSGG IGERYKFLQEMRGYVQDLLECFSEKVPLINELESAIHQLYKQRASRLVQRRQDDIKDESS EFSSHS-------------------NKALMAPNLDSFGRDRALYQEHAK-RRIAERE--- ---ARR-TRR-RQAREQTGKMADHLEGLSSDDEETSTDITNFNLEK--DRISKESSKVFE DVLESFYSIDCIKSQFEAWRSKYYMSYKDAYIGLCLPKLFNPLIRLQLLTWTPLE----- -------------------------------AKCRDFENMLWFESLLFYGCEERE--QEK DDVDVALLPTIVEKVILPKLTVIAENMWDPFSTT--------------QTSRMVGITLKL INGYPSVVNAENKN-----TQVYLKALLLRMRRTLDDDVFMPLYPKNVLENKNSGPYLFF QRQFWSSVKLLGNFLQWYGIFSNKTLQELSIDGLLNRYILMAFQNSEYGDDSIKKAQNVI NCFPKQWFMNLKGERTISQLENFCRYLVHLADTIYRNSIGCSDVDKRNARENIKQIVKLL ASIRALDHAMSVASDH----------------N------------VKEFKSLIEGK-- >ENSMICP00000031482 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------MF----- ------------------------------------------------------------ --------------------RKARRVNVRKRNDSEEEE-------RER------------ -------------------------------------------------------EEEQE ----------------------------------------PP------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------P--------------- ------------------------------------------------------------ -----------LL----------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------------P ------------------------------------------------------------ ------------------------------------------------------------ ----------P-------------------GT---------------------------- ------------------------------------------------------------ ----------------GEEQ-----GP--------------------------------- -----------------------------------GGG--------DRA----------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------P-------------------------------------------- ---------------GGEAL---------------------------------------- ------------------------------------LGPGL-------------PPP--- ------------------------------------------------------------ ---SA-------------LTPGL------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------GAEAGGGFPGGAEPGNGLKPRKR PRENKE--VP-------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------RAS----------------- ------------------LLSF-QDE-EE-EN---------------------------- ---------------------------------------------------------E-- ------EVFKVKKSSYSKKIVKLLKKEYKE------------------------------ ----------------------DLEKSK-------------------------------- ------------------------------------------------------------ ---------------------IKTELN-----------S--------------------- -------------------SADNEQPLDKTGHVKDTSQEDGVIISEHGEDEMDMES---- EKEEE------------------------------------------------------K PKA-GGAFS--------------------------------------------------- -------NALSSLNVLRP-----------GEIPDAAFIHAARKKRQMARELGDFTP-HDN E-PGKGRLVR-ED--ENDA-SD-DEDDDEKRRIVFSVKEKSQRQKIAEE--I---GIEGS DDDALV-TGEQDEELSRWEQEQIRKGINIPQVQASQPAEV-NMYYQNTYQTMPYGSSYGI PYSY--TAY-----------------------------GSS-DAKSQKTDNTVPFKTPSN EMTPVTIDLVKKQLKD-R------------------------------------------ ----------------------LDSMKELHKTNRQQHEKHLQSRVDSTRAIERLEGSSGG IGERYKFLQEMRGYVQDLLECFSEKVPLINELESAIHQLYKQRASRLVQRRQDDIKDESS EFSSHS-------------------NKALMAPNLDSFGRDRALYQEHAK-RRIAERE--- ---ARR-TRR-RQAREQTGKMADHLEGLSSDDEETSTDITNFNLEK--DRISKESSKVFE DVLESFCSIDCIKAQFEAWRSKYYMSYKDAYIGLCLPKLFNPLIRLQLLTWTPLE----- -------------------------------AKCRDFENMLWFESLLFYGCEERE--QEK DDVDVALLPTIVEKVILPKLTVIAENMWDPFSTT--------------QTSRMVGITLKL INGYSSVVNAENKN-----TQVYLKALLLRMRRTLDDDVFMPLYPKNVLENKNSGPYLFF QRQFWSSVKLLGNFLQWYGIFSNKTLQELSIDGLLNRYILMAFQNSEYGDDSIKKAQNVI NCFPKQWFMNLKGERTISQLENFCRYLVHLADTIYRNSIGCSDVEKRNARENIKQIVKLL ASVRALDHAMSVASDH----------------N------------VKEFKSLIEGK-- >ENSPCOP00000031608 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------MF----- ------------------------------------------------------------ --------------------RKARRVNVRKRNDSEEEE-------RER------------ -------------------------------------------------------DEEQE ----------------------------------------PP------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------P--------------- ------------------------------------------------------------ -----------LL----------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------------P ------------------------------------------------------------ ------------------------------------------------------------ ----------P-------------------GT---------------------------- ------------------------------------------------------------ ----------------GEEQ-----GP--------------------------------- -----------------------------------GGG--------DRA----------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------P-------------------------------------------- ---------------GGEAL---------------------------------------- ------------------------------------LGPGL-------------PPP--- ------------------------------------------------------------ ---SA-------------LTPGL------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------GAEAGGSFPGGAEPGNGLKPRKR PRENKE--VP-------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------RAS----------------- ------------------LLSF-QDE-EE-EN---------------------------- ---------------------------------------------------------E-- ------EVFKVKKSSYSKKIVKLLKKEYKE------------------------------ ----------------------DLEKSK-------------------------------- ------------------------------------------------------------ ---------------------IKTELN-----------S--------------------- -------------------SADNEQPLDKTGHVKDISQEDGVIIGEHGEDEMDMES---- EKEDE------------------------------------------------------K PKA-GGAFS--------------------------------------------------- -------NALSSLNVLRP-----------GEIPDAAFIHAARKKRQMARELGDFTP-HDN E-PGKGRLVR-ED--ENDA-SD-DEDDDEKRRIVFSVKEKSQRQKIAEE--I---GIEGS DDDALV-TGEQDEELSRWEQEQIRKGINIPQVQASQPAEV-NMYYQNTYQTMPYGSSYGI PYSY--TAY-----------------------------GSS-DAKSQKTDNTVPFKTPSN EMTPVTIDLVKKQLKD-R------------------------------------------ ----------------------LDSMKELHKTNRQQHEKHLQSRADSTRAIERLEGSSGG IGERYKFLQEMRGYVQDLLECFSEKVPLINELESAIHQLYKQRASRLVQRRQDDIKDESS EFSSHS-------------------NKALMAPNLDSFGRDRALYQEHAK-RRIAERE--- ---ARR-TRR-RQAREQTGKMADHLEGLSSDDEETSTDITNFNLEK--DRISKESSKVFE DVLESFCSIDCIKAQFEAWRSKYYMSYKDAYIGLCLPKLFNPLIRLQLLTWTPLE----- -------------------------------AKCRDFENMLWFESLLFYGCEERE--QEK DDVDIALLPTIVEKVILPKLTVIAENMWDPFSTT--------------QTSRMVGITLKL INGYSSVVNAENKN-----TQVYLKALLLRMRRTLDDDVFMPLYPKNVLENKNSGPYLFF QRQFWSSVKLLGNFLQWYGIFSNKTLQELSIDGLLNRYILMAFQNSEYGDDSIKKAQNVI NCFPKQWFMNLKGERTIFQLENFCRYLVHLADTIYRNSIGCSDVEKRNARENIKQIVKLL ASVRALDHAMSVASDH----------------N------------VKEFKSLIEGK-- >ENSPSMP00000011864 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------MF----- ------------------------------------------------------------ --------------------RKARRVNVRKRNDSEEEE-------RER------------ -------------------------------------------------------EEEQE ----------------------------------------PP------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------P--------------- ------------------------------------------------------------ -----------LL----------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------------P ------------------------------------------------------------ ------------------------------------------------------------ ----------P-------------------GT---------------------------- ------------------------------------------------------------ ----------------GEEP-----GP--------------------------------- -----------------------------------GGG--------DRA----------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------P-------------------------------------------- ---------------GGETL---------------------------------------- ------------------------------------LGPGL------------PPPP--- ------------------------------------------------------------ ---SA-------------LTSGL------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------GAEAGGGFPGGAEPGNGLKPRKR PRENKE--VP-------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------RAS----------------- ------------------LLSF-QDE-EE-EN---------------------------- ---------------------------------------------------------E-- ------EVFKVKKSSYSKKIVKLLKKEYKE------------------------------ ----------------------DLEKSK-------------------------------- ------------------------------------------------------------ ---------------------IKTELN-----------S--------------------- -------------------SADNEQPLDKTGHVKDTSQEDGVIISEHGEDEMDMES---- EKEEE------------------------------------------------------K PKA-GGTFS--------------------------------------------------- -------NALSSLNVLRP-----------GEIPDAAFIHAARKKRQMARELGDFTP-HDN E-PGKGRLVR-ED--ENDA-SD-DEDDDEKRRIVFSVKEKSQRQKIAEE--I---GIEGS DDDALV-TGEQDEELSRWEQEQIRKGINIPQVQASQPAEV-NMYYQNTYQTMPYGSSYGI PYSY--TAY-----------------------------GSS-DAKSQKTDNTVPFKTPSN EMTPVTIDLVKKQLKD-R------------------------------------------ ----------------------LDSMKELHKTNRQQHEKHLQSRVDSTRAIERLEGSSGG IGERYKFLQEMRGYVQDLLECFSEKVPLINELESAIHQLYKQRASRLVQRRQDDIKDESS EFSSHS-------------------NKALMAPNLDSFGRDRALYQEHAK-RRIAERE--- ---ARR-TRR-RQAREQTGKMADHLEGLSSDDEETSTDITNFNLEK--DRISKESSKVFE DVLESFCSIDCIKAQFEAWRSKYYMSYKDAYIGLCLPKLFNPLIRLQLLTWTPLE----- -------------------------------AKCRDFENMLWFESLLFYGCEERE--QEK DDVDVALLPTIVEKVILPKLTVIAENMWDPFSTT--------------QTSRMVGITLKL INGYPSVVNAENKN-----TQVYLKALLLRMRRTLDDDVFMPLYPKNVLENKNSGPYLFF QRQFWSSVKLLGNFLQWYGIFSNKTLQELSIDGLLNRYILMAFQNSEYGDDSIKKAQNVI NCFPKQWFMNLKGERTISQLENFCRYLVHLADTIYRNSIGCSDVEKRNARENIKQIVKLL ASVRALDHAMSVASDH----------------N------------VKEFKSLIEGK-- >ENSCCNP00000030398 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------MF----- ------------------------------------------------------------ --------------------RKARRVNVRKRNDSEEEE-------RER------------ -------------------------------------------------------DEEQE ----------------------------------------PP------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------P--------------- ------------------------------------------------------------ -----------LL----------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------------PP ------------------------------------------------------------ ------------------------------------------------------------ ----------P-------------------AT---------------------------- ------------------------------------------------------------ ----------------GEEP-----GP--------------------------------- -----------------------------------GGG--------DRA----------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------P-------------------------------------------- ---------------GGESL---------------------------------------- ------------------------------------LGPGL-------------PPP--- ------------------------------------------------------------ ---SA-------------LTPGL------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------GAEAGGGFPSGAEPGNGLKPRKR PRENKE--VP-------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------RAS----------------- ------------------LLSF-QDE-EE-EN---------------------------- ---------------------------------------------------------E-- ------EVFKVKKSSYSKKIVKLLKKEYKE------------------------------ ----------------------DLEKSK-------------------------------- ------------------------------------------------------------ ---------------------IKTELN-----------S--------------------- -------------------SADNDQPVDKSGHVKDTNQEDGVIISEHGEDEMDMES---- EKEEE------------------------------------------------------K PKT-AGAFS--------------------------------------------------- -------NALSSLNVLRP-----------GEIPDAAFIHAARKKRQMARELGDFTP-HDN E-PGKGRLVR-ED--ENDA-SD-DEDDDEKRRIVFSVKEKSQRQKIAEE--I---GIEGS DDDALV-TGEQDEELSRWEQEQIRKGINIPQVQASQPSEV-NMYYQSTYQTMPYGSSYDI PYSY--TTY-----------------------------GSS-DAKSQKTDNTVPFKTPSN EMTPVTIDLVKKQLKD-R------------------------------------------ ----------------------LDSMKELHKTNRQQHEKHLQSRVDSTRAIERLEGSSGG IGERYKFLQEMRGYVQDLLECFSEKVPLINELESAIHQLYKQRASRLVQRRQDDIKDESS EFSSHS-------------------NKALMAPNLDSFGRDRALYQEHAK-RRIAERE--- ---ARR-TRR-RQAREQTGKMADHLEGLSSDDEETSTDITNFNLEK--DRISKESSKVFE DVLESFYSIDCIKSQFEAWRSKYYMSYKDAYIGLCLPKLFNPLIRLQLLTWTPLE----- -------------------------------AKCRDFENMLWFESLLFYGCEERE--QEK DDVDVALLPTIVEKVILPKLTVIAENMWDPFSTT--------------QTSRMVGITLKL INGYPSVVNAENKN-----TQVYLKALLLRMRRTLDDDVFMPLYPKNVLENKNSGPYLFF QRQFWSSVKLLGNFLQWYGIFSNKTLQELSIDGLLNRYILMAFQNSEYGDDSIKKAQNVI NCFPKQWFMNLKGERTISQLENFCRYLVHLADTIYRNSIGCSDVEKRNARENIKQIVKLL ASVRALDHAMSVASDH----------------N------------VKEFKSLIEGK-- >ENSMPUP00000001214 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------MF----- ------------------------------------------------------------ --------------------RKARRVNVRKRNDSEEEE-------RER------------ -------------------------------------------------------DEEQE ----------------------------------------PP------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------P--------------- ------------------------------------------------------------ -----------LL----------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------------PP ------------------------------------------------------------ ------------------------------------------------------------ ----------P-------------------GT---------------------------- ------------------------------------------------------------ ----------------GEEPGSGGGGSG-------------------------------- -----------------------------------GGG--------DRA----------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------P-------------------------------------------- ---------------GGESL---------------------------------------- ------------------------------------QGPGL-------------LPP--- ------------------------------------------------------------ ---SA-------------LTPGF------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------GAEAGGCFPGGAEPGNGLKPRKR PRENKE--VP-------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------RAS----------------- ------------------LLSF-QDE-EE-EN---------------------------- ---------------------------------------------------------E-- ------EVFKVKKSSYSKKIVKLLKKEYKE------------------------------ ----------------------DLEKSK-------------------------------- ------------------------------------------------------------ ---------------------IKTELN-----------S--------------------- -------------------STDSEPPLDKTGHVKDTSQEDGLIISEHGEDEMDMES---- EKEEE------------------------------------------------------K PKA-GGAFS--------------------------------------------------- -------NALSSLNVLRP-----------GEIPDAAFIHAARKKRQMARELGDFTP-HDN E-PGKGRLVR-ED--ENDA-SD-DEDDDEKRRIVFSVKEKSQRQKIAEE--I---GIEGS DDDALV-TGEQDEELSRWEQEQIRKGINIPQVQSSQPTEV-NMYYQNTYQTMPYGSSYGI PYSY--TAY-----------------------------GSS-DAKSQKTDNTVPFKTPSN EMTPVTIDLVKKQLKD-R------------------------------------------ ----------------------LDSMKELHKTNRQQHEKHLQSRVDSTRAIERLEGSSGG IGERYKFLQEMRGYVQDLLECFSEKVPLINELESAIHQLYKQRASRLVQRRQDDIKDESS EFSSHS-------------------NKALMAPNLDSFGRDRALYQEHAK-RRIAERE--- ---ARR-TRR-RQAREQTGKMADHLEGLSSDDEETSTDITNFNLEK--DRISKESSKVFE DVLESFYSIDCIKSQFEAWRSKYYLSYKDAYIGLCLPKLFNPLIRLQLLTWTPLE----- -------------------------------AKCRDFENMLWFESLLFYGCEERE--QEK DDVDVALLPTIVEKVILPKLTVIAENMWDPFSTT--------------QTSRMVGITLKL INGYPSVVNAENKN-----TQVYLKALLLRMRRTLDDDVFMPLYPKNVLENKNSGPYLFF QRQFWSSVKLLGNFLQWYGIFSNKTLQELSIDGLLNRYILMAFQNSEYGDDSIKKAQNVI NCFPKQWFMNLKGERTISQLENFCRYLVHLADTIYRNSIGCSDVEKRNARENIKQIVKLL ASVRALDHAMSVASDH----------------N------------VKEFKSLIEGK-- >ENSPTIP00000018959 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------AEAAGCFPGGAEPGNGLKPRKR QRENKE--VP-------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------RAS----------------- ------------------LLSF-QDE-EE-EN---------------------------- ---------------------------------------------------------E-- ------EVFKVKKSSYSKKIVKLLKKEYKE------------------------------ ----------------------DLEKSK-------------------------------- ------------------------------------------------------------ ---------------------IKTELN-----------S--------------------- -------------------SADSEPPLDKTGHIKDTSQEDGVIISEHGEDEMDMES---- EKEEE------------------------------------------------------K PKA-GGAFS--------------------------------------------------- -------NALSSLNVLRP-----------GEIPDAAFIHAARKKRQMARELGDFTP-HDS E-PGKGRLVR-ED--ENDA-SD-DEDDDEKRRIVFSVKEKSQRQKIAEE--I---GIEGS DDDALV-TGEQDEELSRWEQEQIRKGINIPQVQASQPTEV-NMYYQNTYQTIPYGSSYGI PYSY--TAY-----------------------------GSS-DAKSQKTDNTVPFKTPSN EMTPVTIDLVKKQLKD-R------------------------------------------ ----------------------LDSVKELHKTNRQQHEKHLQSRVDATRAIERLEGSSGG VGERYKFLQEMRGYVQDLLECFSEKVPLINELESAIHQLYKQRASRLVQRRQDDIKDESS EFSSHS-------------------NKALMAPNLDSFGRDRALYQEHAK-RRIAERE--- ---ARR-TRR-RQAREQTGKMADHLEGLSSDDEETSTDITNFNLEK--DRISKESSKVFE DVLESFYSIDCIKSQFEAWRSKYYLSYKDAYIGLCLPKLFNPLIRLQLLTWTPLE----- -------------------------------AKCRDFENMLWFESLLFYGCEERE--QEK DDVDVALLPTIVEKVILPKLTVIAENMWDPFSTT--------------QTSRMVGITLKL INGYPSVVNAENKN-----TQVYLKALLLRMRRTLDDDVFMPLYPKNVLENKNSGPYLFF QRQFWSSVKLLGNFLQWYGIFSNKTLQELSIDGLLNRYILMAFQNSEYGDDSIKKAQNVI NCFPKQWFMNLKGERTISQLENFCRYLVHLADTIYRNSIGCSDVEKRNARENIKQIVKLL ASVRALDHAMSVASDH----------------N------------VKEFKSLIEGK-- >ENSFCAP00000011596 M-------------------R---------------------ARWCAVERGKTG------ --------------------------PGWSSGKRAC------------AVASLELPGQPC GSGCETAVRAA------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------GMF----- ------------------------------------------------------------ --------------------RKARRVNVRKRNDSEEEE-------RER------------ -------------------------------------------------------DEEQE ----------------------------------------PP------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------P--------------- ------------------------------------------------------------ -----------LL----------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------------QP ------------------------------------------------------------ ------------------------------------------------------------ ----------P-------------------GT---------------------------- ------------------------------------------------------------ ----------------GEEP-----GSG-------------------------------- -----------------------------------GGG--------DRA----------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------P-------------------------------------------- ---------------GGESL---------------------------------------- ------------------------------------QGPGL-------------PPP--- ------------------------------------------------------------ ---SA-------------LTPGS------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------GAEAGGCFPGGAEPGNGLKPRKR PRENKE--VP-------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------RAS----------------- ------------------LLSF-QDE-EE-EN---------------------------- ---------------------------------------------------------E-- ------EVFKVKKSSYSKKIVKLLKKEYKE------------------------------ ----------------------DLEKSK-------------------------------- ------------------------------------------------------------ ---------------------IKTELN-----------S--------------------- -------------------SADSEPPLDKTGHIKDTSQEDGVIISEHGEDEMDMES---- EKEEE------------------------------------------------------K PKA-GGAFS--------------------------------------------------- -------NALSSLNVLRP-----------GEIPDAAFIHAARKKRQMARELGDFTP-HDS E-PGKGRLVR-ED--ENDA-SD-DEDDDEKRRIVFSVKEKSQRQKIAEE--I---GIEGS DDDALV-TGEQDEELSRWEQEQIRKGINIPQVQASQPTEV-NMYYQNTYQTIPYGSSYGI PYSY--TAY-----------------------------GSS-DAKSQKTDNTVPFKTPSN EMTPVTIDLVKKQLKD-R------------------------------------------ ----------------------LDSVKELHKTNRQQHEKHLQSRVDATRAIERLEGSSGG VGERYKFLQEMRGYVQDLLECFSEKVPLINELESAIHQLYKQRASRLVQRRQDDIKDESS EFSSHS-------------------NKALMAPNLDSFGRDRALYQEHAK-RRIAERE--- ---ARR-TRR-RQAREQTGKMADHLEGLSSDDEETSTDITNFNLEK--DRISKESSKVFE DVLESFYSIDCIKSQFEAWRSKYYLSYKDAYIGLCLPKLFNPLIRLQLLTWTPLE----- -------------------------------AKCRDFENMLWFESLLFYGCEERE--QEK DDVDVALLPTIVEKVILPKLTVIAENMWDPFSTT--------------QTSRMVGITLKL INGYPSVVNAENKN-----TQVYLKALLLRMRRTLDDDVFMPLYPKNVLENKNSGPYLFF QRQFWSSVKLLGNFLQWYGIFSNKTLQELSIDGLLNRYILMAFQNSEYGDDSIKKAQNVI NCFPKQWFMNLKGERTISQLENFCRYLVHLADTIYRNSIGCSDVEKRNARENIKQIVKLL ASVRALDHAMSVASDH----------------N------------VKEFKSLIEGK-- >ENSPPRP00000001131 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------MF----- ------------------------------------------------------------ --------------------RKARRVNVRKRNDSEEEE-------RER------------ -------------------------------------------------------DEEQE ----------------------------------------PP------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------P--------------- ------------------------------------------------------------ -----------LL----------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------------QP ------------------------------------------------------------ ------------------------------------------------------------ ----------P-------------------GT---------------------------- ------------------------------------------------------------ ----------------GEEP-----GSG-------------------------------- -----------------------------------GGG--------DRA----------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------P-------------------------------------------- ---------------GGESL---------------------------------------- ------------------------------------QGPGL-------------PPP--- ------------------------------------------------------------ ---SA-------------LTPGS------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------GAEAGGCFPGGAEPGNGLKPRKR PRENKE--VP-------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------RAS----------------- ------------------LLSF-QDE-EE-EN---------------------------- ---------------------------------------------------------E-- ------EVFKVKKSSYSKKIVKLLKKEYKE------------------------------ ----------------------DLEKSK-------------------------------- ------------------------------------------------------------ ---------------------IKTELN-----------S--------------------- -------------------SADSEPPLDKTGHIKDTSQEDGVIISEHGEDEMDMES---- EKEEE------------------------------------------------------K PKA-GGAFS--------------------------------------------------- -------NALSSLNVLRP-----------GEIPDAAFIHAARKKRQMARELGDFTP-HDS E-PGKGRLVR-ED--ENDA-SD-DEDDDEKRRIVFSVKEKSQRQKIAEE--I---GIEGS DDDALV-TGEQDEELSRWEQEQIRKGINIPQVQASQPTEV-NMYYQNTYQTIPYGSSYGI PYSY--TAY-----------------------------GSS-DAKSQKTDNTVPFKTPSN EMTPVTIDLVKKQLKD-R------------------------------------------ ----------------------LDSVKELHKTNRQQHEKHLQSRVDATRAIERLEGSSGG VGERYKFLQEMRGYVQDLLECFSEKVPLINELESAIHQLYKQRASRLVQRRQDDIKDESS EFSSHS-------------------NKALMAPNLDSFGRDRALYQEHAK-RRIAERE--- ---ARR-TRR-RQAREQTGKMADHLEGLSSDDEETSTDITNFNLEK--DRISKESSKVFE DVLESFYSIDCIKSQFEAWRSKYYLSYKDAYIGLCLPKLFNPLIRLQLLTWTPLE----- -------------------------------AKCRDFENMLWFESLLFYGCEERE--QEK DDVDVALLPTIVEKVILPKLTVIAENMWDPFSTT--------------QTSRMVGITLKL INGYPSVVNAENKN-----TQVYLKALLLRMRRTLDDDVFMPLYPKNVLENKNSGPYLFF QRQFWSSVKLLGNFLQWYGIFSNKTLQELSIDGLLNRYILMAFQNSEYGDDSIKKAQNVI NCFPKQWFMNLKGERTISQLENFCRYLVHLADTIYRNSIGCSDVEKRNARENIKQIVKLL ASVRALDHAMSVASDH----------------N------------VKEFKSLIEGK-- >ENSAMEP00000015826 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------MF----- ------------------------------------------------------------ --------------------RKARRVNVRKRNDSEEEE-------RER------------ -------------------------------------------------------DEEQE ----------------------------------------PP------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------P--------------- ------------------------------------------------------------ -----------LL----------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------------PP ------------------------------------------------------------ ------------------------------------------------------------ ----------P-------------------GT---------------------------- ------------------------------------------------------------ ----------------GEEP-----GSG-------------------------------- -----------------------------------GGG--------DRA----------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------P-------------------------------------------- ---------------GGESL---------------------------------------- ------------------------------------QGPGL-------------PPP--- ------------------------------------------------------------ ---SA-------------LTSGS------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------GAEAGGCFPGGAEPGNGLKPRKR PRENKE--VP-------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------RAS----------------- ------------------LLSF-QDE-EE-EN---------------------------- ---------------------------------------------------------E-- ------EVFKVKKSSYSKKIVKLLKKEYKE------------------------------ ----------------------DLEKSK-------------------------------- ------------------------------------------------------------ ---------------------IKTELN-----------S--------------------- -------------------SADNEPLLDKAGHVKDTSQEDGVIISEHGEDEMDMES---- EKEEE------------------------------------------------------K PKA-GGAFS--------------------------------------------------- -------NALSSLNVLRP-----------GEIPDAAFIHAARKKRQMARELGDFTP-HDS E-PGKGRLVR-ED--ENDA-SD-DEDDDEKRRIVFSVKEKSQRQKIAEE--I---GIEGS DDDALV-TGEQDEELSRWEQEQIRKGINIPQVQASQPTEV-NMYYQNTYQTMPYGSSYGI PYSY--TAY-----------------------------GSS-DAKSQKTDNTVPFKTPSN EMTPVTIDLVKKQLKD-R------------------------------------------ ----------------------LDSMKELHKTNRQQHEKHLQSRVDSTRAIERLEGSSGG IGERYKFLQEMRGYVQDLLECFSEKVPLINELESAIHQLYKQRASRLVQRRQDDIKDESS EFSSHS-------------------NKALMAPNLDSFGRDRALYQEHAK-RRIAERE--- ---ARR-TRR-RQAREQTGKMADHLEGLSSDDEETSTDITNFNLEK--DRISKESSKVFE DVLESFYSIDCIKSQFEAWRSKYYLSYKDAYIGLCLPKLFNPLIRLQLLTWTPLE----- -------------------------------AKCRDFENMLWFESLLFYGCEERE--QEK DDVDVALLPTIVEKVILPKLTVIAENMWDPFSTT--------------QTSRMVGITLKL INGYPSVVNAENKN-----TQVYLKALLLRMRRTLDDDVFMPLYPKNVLENKNSGPYLFF QRQFWSSVKLLGNFLQWYGIFSNKTLQELSIDGLLNRYILMAFQNSEYGDDSIKKAQNVI SCFPKQWFMNLKGERTISQLENFCRYLVHLADTIYRNSIGCSDVEKRNARENIKQIVKLL ASVHALDHAMSVASDH----------------N------------VKEFKSLIEGK-- >ENSUAMP00000026663 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------MF----- ------------------------------------------------------------ --------------------RKARRVNVRKRNDSEEEE-------RER------------ -------------------------------------------------------DEEQE ----------------------------------------PP------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------P--------------- ------------------------------------------------------------ -----------LL----------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------------PP ------------------------------------------------------------ ------------------------------------------------------------ ----------P-------------------GT---------------------------- ------------------------------------------------------------ ----------------GEEP-----GSG-------------------------------- -----------------------------------GGG--------DRA----------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------P-------------------------------------------- ---------------GGESL---------------------------------------- ------------------------------------QGPGL-------------PPP--- ------------------------------------------------------------ ---SA-------------LTSGS------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------GAEAGGCFPGGAEPGNGLKPRKR PRENKE--VP-------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------RAS----------------- ------------------LLSF-QDE-EE-EN---------------------------- ---------------------------------------------------------E-- ------EVFKVKKSSYSKKIVKLLKKEYKE------------------------------ ----------------------DLEKSK-------------------------------- ------------------------------------------------------------ ---------------------IKTELN-----------S--------------------- -------------------SADNEPPLDKAGHVKDTSQEDGVIISEHGEDEMDMES---- EKEEE------------------------------------------------------K PKA-GGAFS--------------------------------------------------- -------NALSSLNVLRP-----------GEIPDAAFIHAARKKRQMARELGDFTP-HDS E-PGKGRLVR-ED--ENDA-SD-DEDDDEKRRIVFSVKEKSQRQKIAEE--I---GIEGS DDDALV-TGEQDEELSRWEQEQIRKGINIPQVQASQPTEV-NMYYQNTYQTMPYGSSYGI PYSY--TAY-----------------------------GSS-DAKSQKTDNTVPFKTPSN EMTPVTIDLVKKQLKD-R------------------------------------------ ----------------------LDSMKELHKTNRQQHEKHLQSRVDSTRAIERLEGSSGG IGERYKFLQEMRGYVQDLLECFSEKVPLINELESAIHQLYKQRASRLVQRRQDDIKDESS EFSSHS-------------------NKALMAPNLDSFGRDRALYQEHAK-RRIAEREESL -LS----------AREQTGKMADHLEGLSSDDEETSTDITNFNLEK--DRISKESSKVFE DVLESFYSIDCIKSQFEAWRSKYYLSYKDAYIGLCLPKLFNPLIRLQLLTWTPLE----- -------------------------------AKCRDFENMLWFESLLFYGCEERE--QEK DDVDVALLPTIVEKVILPKLTVIAENMWDPFSTT--------------QTSRMVGITLKL INGYPSVVNAENKN-----TQVYLKALLLRMRRTLDDDVFMPLYPKNVLENKNSGPYLFF QRQFWSSVKLLGNFLQWYGIFSNKTLQELSIDGLLNRYILMAFQNSEYGDDSIKKAQNVI SCFPKQWFMNLKGERTISQLENFCRYLVHLADTIYRNSIGCSDVEKRNARENIKQIVKLL ASVRALDHAMSVASDH----------------N------------VKEFKSLIEGK-- >ENSECAP00000014331 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------MF----- ------------------------------------------------------------ --------------------RKARRVNVRKRNDSEEEE-------RER------------ -------------------------------------------------------DEEQE ----------------------------------------PP------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------P--------------- ------------------------------------------------------------ -----------LL----------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------------PP ------------------------------------------------------------ ------------------------------------------------------------ ----------P-------------------GT---------------------------- ------------------------------------------------------------ ----------------GEEP-----GPG-------------------------------- -----------------------------------GGG--------DRA----------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------P-------------------------------------------- ---------------GGESL---------------------------------------- ------------------------------------LGPGL-------------PPP--- ------------------------------------------------------------ ---SA-------------LTPGP------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------GAEAGGCFPGGAEPGNGLKPRKR PRENKE--VP-------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------RAS----------------- ------------------LLSF-QDE-EE-EN---------------------------- ---------------------------------------------------------E-- ------EVFKVKKSSYSKKIVKLLKKEYKE------------------------------ ----------------------DLEKSK-------------------------------- ------------------------------------------------------------ ---------------------IKTELN-----------S--------------------- -------------------SADNEPSLDKTGHVKDTSQEDGVIISEHGEDEMDMES---- EKEEE------------------------------------------------------K PKA-GGAFS--------------------------------------------------- -------NALSSLNVLRP-----------GEIPDAAFIHAARKKRQMARELGDFTP-HDS E-PGKGRLVR-ED--ENDA-SD-DEDDDEKRRIVFSVKEKSQRQKIAEE--I---GIEGS DDDALV-TGEQDEELSRWEQEQIRKGINIPQVQASQPAEV-NMYYQNTYQTMPYGSSYGI PYSY--TAY-----------------------------GSS-DAKSQKTDNTVPFKTPSN EMTPVTIDLVKKQLKD-R------------------------------------------ ----------------------LDSMKELHKTNRQQHEKHLQSRVDSTRAIERLEGSSGG IGERYKFLQEMRGYVQDLLECFSEKVPLINELESAIHQLYKQRASRLVQRRQDDIKDESS EFSSHS-------------------NKALMAPNLDSFGRDRALYQEHAK-RRIAERE--- ---ARR-TRR-RQAREQTGKMADHLEGLSSDDEETSTDITNFNLEK--DRISKESSKVFE DVLESFYSIDCIKSQFEAWRSKYYMSYKDAYIGLCLPKLFNPLIRLQLLTWTPLE----- -------------------------------AKCRDFETMLWFESLLFYGCEERE--QEK DDVDVALLPTIVEKVILPKLTVIAENMWDPFSTT--------------QTSRMVGITLKL INGYPSVVNAENKN-----TQVYLKALLLRMRRTLDDDVFMPLYPKNVLENKNSGPYLFF QRQFWSSVKLLGNFLQWYGIFSNKTLQELSIDGLLNRYILMAFQNSEYGDDSIKKAQNVI NCFPKQWFMNLKGERTISQLENFCRYLVHLADTIYRNSIGCSDVEKRNARENIKQIVKLL ASVRALDHAMSVASDH----------------N------------VKEFKSLIEGK-- >ENSTSYP00000006051 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------MF----- ------------------------------------------------------------ --------------------RKARRVNVRKRNDSEEEE-------RER------------ -------------------------------------------------------DEEQE ----------------------------------------PP------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------P--------------- ------------------------------------------------------------ -----------LL----------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------XXXXXXSLP--------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------GPGL-------------PPP--- ------------------------------------------------------------ ---SA-------------LTPGL------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------GAEAGGGFPGSAEPGNGLKPRKR PRENKE--VP-------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------RAS----------------- ------------------LLSF-QDE-EE-ET---------------------------- ---------------------------------------------------------E-- ------EVFKVKKSSYSKKIVKLLKKEYKE------------------------------ ----------------------DLEKSK-------------------------------- ------------------------------------------------------------ ---------------------IKIELN-----------S--------------------- -------------------SADNEHPLDKTGHIKDTNQEDGVIISEHGEDEMDMES---- EKEEE------------------------------------------------------K PKA-GGAFS--------------------------------------------------- -------NALSSLNVLRP-----------GEIPDAAFIHAARKKRQMARELGDFTP-HDN E-PGKGRLVR-ED--ENDA-SD-DEDDDEKRRIVFSVKEKSQRQKIAEE--I---GIEGS DDDALV-TGEQDEELSRWEQEQIRKGINIPQVQASQPTEV-NMYYQNTYQTMPYGSSYGI PYSY--TTY-----------------------------GSS-DAKSQKTDNTVPFKTPSN EMTPVTIDLVKKQLKD-R------------------------------------------ ----------------------LDSMKELHKTNRQQHEKHLQSRVDSTRAIERLEGSSGG IGERYKFLQEMRGYVQDLLECFSEKVPLINELESAIHQLYKQRASRLVQRRQDDIKDESS EFSSHS-------------------NKALMAPNLDSFGRDRALYQEHAK-RRIAERE--- ---ARR-TRR-RQAREQTGKMADHLEGLSSDDEETSTDITNFNLEK--DRISKESSKVFE DVLESFYSIDCIKSQFEAWRSKYYMSYKDAYIGLCLPKLFNPLIRLQLLTWTPLE----- -------------------------------AKCRDFESMLWFESLLFYGCEERE--QEK DDVDVALLPTIVEKVILPKLTVIAENVWDPFSTT--------------QTSRMVGITLKL INGYPSVVNAENKN-----TQVYLKALLLRMRRTLDDDVFMPLYPKNVLENKNSGPYLFF QRQFWSSVKLLGNFLQWYGIFSNKTLQELSIDGLLNRYILMAFQNSEYGDDSIKKAQNVI NCFPKQWFINLKGERTISQLENFCRYLVHLADTIYRNSIGCSDVEKRNARENIKQIVKLL ASVRALDHAMSVASDH----------------N------------VKEFKSLIEGK-- >ENSFDAP00000002220 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------MF----- ------------------------------------------------------------ --------------------RKARRVNVRKRNDSEEEE-------RE------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------PGGAEPGNGLKPRKR PRENKE--VP-------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------RAS----------------- ------------------LLSF-QDE-EE-EN---------------------------- ---------------------------------------------------------E-- ------EVFKVKKSSYSKKIVKLLKKEYKE------------------------------ ----------------------DLEKSK-------------------------------- ------------------------------------------------------------ ---------------------IKNELN-----------S--------------------- -------------------SADNEQSLDKTGHVKDTNPEDGVIISEHGEDEMDMES---- EKEEE------------------------------------------------------K PKA-GGTFS--------------------------------------------------- -------NTLSSLNVLRP-----------GEIPDAAFIHAARKKRQMARELGDFTP-HDN E-PGKGRLVR-ED--ENDA-SD-DEDDDEKRRIVFSVKEKSQRQKIAEE--I---GIEGS DDDALV-TGEQDEELSRWEQEQIRKGINIPQVQASQPAEV-NMYYQNTYQTMPYSSSYGI PYSY--TAY-----------------------------GSS-DAKSQKTDNTVPFKTPSN EMTPVTIDLVKKQLKD-R------------------------------------------ ----------------------LDSVKDLHRTNRQQHEKHLQSRVDSTRAIERLEGSSGG IGERYKFLQEMRGYVQDLLECFSEKVPLINELESAIHQLYKQRASRLVQRRQDDIKDESS EFSSHS-------------------NKALMAPNLDSFGRDRALYQEHAK-RRIAERE--- ---ARR-TRR-RQAREQTGKMADHLEGLSSDDEETSTDITNFNLEK--DRISKESSKVFE DVLESFYSIDCIKSQFEAWRSKYYMSYKDAYIGLCLPKLFNPLIRLQLLTWTPLE----- -------------------------------AKCRDFENMLWFESLLFYGCEEQE--QEK DDVDVALLPTIVEKVILPKLTVIAENMWDPFSTT--------------QTSRMVGITLKL INGYPSVVNAENKN-----TQVYLKALLLRMRRTLDDDVFMPLYPKNVLENKNSGPYLFF QRQFWSSVKLLGNFLQWYGIFSNKTLQELSIDGLLNRYILMAFQNSEYGDDSIKKAQNVI NCFPKQWFVNLKGERTISQLENFCRYLVHLADTIYRNSIGCSDVEKRNARENIKQIVKLL ASVRALDHAMSVASDH----------------N------------VKEVKSLIEGK-- >ENSBTAP00000003986 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------MF----- ------------------------------------------------------------ --------------------RKARRVNVRKRNDSEEEE-------RER------------ -------------------------------------------------------DEEQE ----------------------------------------PP------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------P--------------- ------------------------------------------------------------ -----------LL----------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------------PP ------------------------------------------------------------ ------------------------------------------------------------ ----------P------------------------------------------------- ------------------------------------------------------------ --PGT-----------GEE----------------------------------------- ------------------------------PGPGGGGG--------DRA----------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------P-------------------------------------------- ---------------AGESL---------------------------------------- ------------------------------------LGPGPP----P-----PPPPP--- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------AALTSGTEAGGCLPGGLEPGNGLKPRKR PRENKE--VP-------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------RAS----------------- ------------------LLSF-QDE-DE-EN---------------------------- ---------------------------------------------------------E-- ------EVFKVKKSSYSKKIVKLLKKEYKE------------------------------ ----------------------DLEKSK-------------------------------- ------------------------------------------------------------ ---------------------IKTELN-----------S--------------------- -------------------SADNEPPLDKAGHVKDTSLEDGVIISEHGEDEMDMES---- EKEEE------------------------------------------------------K PKA-GGAFS--------------------------------------------------- -------NALSSLNVLRP-----------GEIPDAAFIHAARKKRQMARELGDFTP-HDS E-PGKGRLVR-ED--ENDA-SD-DEDDDEKRRIVFSVKEKSQRQKIAEE--I---GIEGS DDDALV-TGEQDEELSRWEQEQIRKGINIPQVQASQPTEV-NMYYQNTYQTMPYGSSYGI PYSY--SAY-----------------------------GSS-DAKSQKTDNTVPFKTPSN EMTPVTIDLVKKQLKD-R------------------------------------------ ----------------------LDSMKELHKTNRQQHEKHLQSRADSTRAIERLEGSSGG IGERYKFLQEMRGYVQDLLECFSEKVPLINELESAIHQLYKQRASRLVQRRQDDIKDESS EFSSHS-------------------NKALMAPNLDSFGRDRALYQEHAK-RRIAERE--- ---ARR-TRR-RQAREQTGKMADHLEGLSSDDEETSTDITNFNLEK--DRISKESSKVFE DVLESFYSIDCIKSQFEAWRSKYYTSYKHAYIGLCLPKLLNPLIRLQLLTWTPLE----- -------------------------------AKCRDFENMLWFESLLFYGCEERE--QEK DDVDVALLPTIVEKVILPKLTVIAENMWDPFSTT--------------QTSRMVGITLKL INGYPSVVNAENKN-----TQVYLKALLLRMRRTLDDDVFMPLYPKNVLENKNSGPYLFF QRQFWSSVKLLGNFLQWYGIFSNKTLQELSIDGLLNRYILMAFQNSEYGDDSIKKAQNVI NCFPKQWFVNLKGERTISQLENFCRYLVHLADTIYRNSIGCSDVEKRNARENIKQIVKLL ASVRALDHAMSVASDH----------------N------------VKEFKSLIEGK-- >ENSBIXP00000042233 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------MF----- ------------------------------------------------------------ --------------------RKARRVNVRKRNDSEEEE-------RER------------ -------------------------------------------------------DEEQE ----------------------------------------PP------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------P--------------- ------------------------------------------------------------ -----------LL----------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------------PP ------------------------------------------------------------ ------------------------------------------------------------ ----------P------------------------------------------------- ------------------------------------------------------------ --PGT-----------GEE----------------------------------------- ------------------------------PGPGGGGG--------DRA----------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------P-------------------------------------------- ---------------AGESL---------------------------------------- ------------------------------------LGPGPP----P-----PPPPP--- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------AALTSGTEAGGCLPGGLEPGNGLKPRKR PRENKE--VP-------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------RAS----------------- ------------------LLSF-QDE-DE-EN---------------------------- ---------------------------------------------------------E-- ------EVFKVKKSSYSKKIVKLLKKEYKE------------------------------ ----------------------DLEKSK-------------------------------- ------------------------------------------------------------ ---------------------IKTELN-----------S--------------------- -------------------SADNEPPLDKAGHVKDTSLEDGVIISEHGEDEMDMES---- EKEEE------------------------------------------------------K PKA-GGAFS--------------------------------------------------- -------NALSSLNVLRP-----------GEIPDAAFIHAARKKRQMARELGDFTP-HDS E-PGKGRLVR-ED--ENDA-SD-DEDDDEKRRIVFSVKEKSQRQKIAEE--I---GIEGS DDDALV-TGEQDEELSRWEQEQIRKGINIPQVQASQPTEV-NMYYQNTYQTMPYGSSYGI PYSY--SAY-----------------------------GSS-DAKSQKTDNTVPFKTPSN EMTPVTIDLVKKQLKD-R------------------------------------------ ----------------------LDSMKELHKTNRQQHEKHLQSRADSTRAIERLEGSSGG IGERYKFLQEMRGYVQDLLECFSEKVPLINELESAIHQLYKQRASRLVQRRQDDIKDESS EFSSHS-------------------NKALMAPNLDSFGRDRALYQEHAK-RRIAERE--- ---ARR-TRR-RQAREQTGKMADHLEGLSSDDEETSTDITNFNLEK--DRISKESSKVFE DVLESFYSIDCIKSQFEAWRSKYYTSYKHAYIGLCLPKLLNPLIRLQLLTWTPLE----- -------------------------------AKCRDFENMLWFESLLFYGCEERE--QEK DDVDVALLPTIVEKVILPKLTVIAENMWDPFSTT--------------QTSRMVGITLKL INGYPSVVNAENKN-----TQVYLKALLLRMRRTLDDDVFMPLYPKNVLENKNSGPYLFF QRQFWSSVKLLGNFLQWYGIFSNKTLQELSIDGLLNRYILMAFQNSEYGDDSIKKAQNVI NCFPKQWFVNLKGERTISQLENFCRYLVHLADTIYRNSIGCSDVEKRNARENIKQIVKLL ASVRALDHAMSVASDH----------------N------------VKEFKSLIEGK-- >ENSBMUP00000010819 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------MF----- ------------------------------------------------------------ --------------------RKARRVNVRKRNDSEEEE-------RER------------ -------------------------------------------------------DEEQE ----------------------------------------PP------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------P--------------- ------------------------------------------------------------ -----------LL----------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------------PP XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX XXXXXXXXXXXXXXXXXXX----------------------------------------- ---------X-------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------N---------------------------- ---------------------------------------------------------E-- ------EVFKVKKSSYSKKIVKLLKKEYKE------------------------------ ----------------------DLEKSK-------------------------------- ------------------------------------------------------------ ---------------------IKTELN-----------S--------------------- -------------------SADNEPPLDKAGHVKDTSLEDGVIISEHGEDEMDMES---- EKEEE------------------------------------------------------K PKA-GGAFS--------------------------------------------------- -------NALSSLNVLRP-----------GEIPDAAFIHAARKKRQMARELGDFTP-HDS E-PGKGRLVR-ED--ENDA-SD-DEDDDEKRRIVFSVKEKSQRQKIAEE--I---GIEGS DDDALV-TGEQDEELSRWEQEQIRKGINIPQVQASQPTEV-NMYYQNTYQTMPYGSSYGI PYSY--SAY-----------------------------GSS-DAKSQKTDNTVPFKTPSN EMTPVTIDLVKKQLKD-R------------------------------------------ ----------------------LDSMKELHKTNRQQHEKHLQSRADSTRAIERLEGSSGG IGERYKFLQEMRGYVQDLLECFSEKVPLINELESAIHQLYKQRASRLVQRRQDDIKDESS EFSSHS-------------------NKALMAPNLDSFGRDRALYQEHAK-RRIAERE--- ---ARR-TRR-RQAREQTGKMADHLEGLSSDDEETSTDITNFNLEK--DRISKESSKVFE DVLESFYSIDCIKSQFEAWRSKYYTSYKHAYIGLCLPKLLNPLIRLQLLTWTPLE----- -------------------------------AKCRDFENMLWFESLLFYGCEERE--QEK DDVDVALLPTIVEKVILPKLTVIAENMWDPFSTT--------------QTSRMVGITLKL INGYPSVVNAENKN-----TQVYLKALLLRMRRTLDDDVFMPLYPKNVLENKNSGPYLFF QRQFWSSVKLLGNFLQWYGIFSNKTLQELSIDGLLNRYILMAFQNSEYGDDSIKKAQNVI NCFPKQWFVNLKGERTISQLENFCRYLVHLADTIYRNSIGCSDVEKRNARENIKQIVKLL ASVRALDHAMSVASDH----------------N------------VKEFKSLIEGK-- >ENSBIXP00005045787 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------MF----- ------------------------------------------------------------ --------------------RKARRVNVRKRNDSEEEE-------RER------------ -------------------------------------------------------DEEQE ----------------------------------------PP------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------P--------------- ------------------------------------------------------------ -----------LL----------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------------PP ------------------------------------------------------------ ------------------------------------------------------------ ----------P------------------------------------------------- ------------------------------------------------------------ --PGT-----------GEEP-----GPG-------------------------------- ------------------------------PGPGGGGG--------DRA----------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------P-------------------------------------------- ---------------AGESL---------------------------------------- ------------------------------------LGPGP-----------PPPPP--- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------AALTSGTEAGGCLPGGLEPGNGLKPRKR PRENKE--VP-------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------RAS----------------- ------------------LLSF-QDE-DE-EN---------------------------- ---------------------------------------------------------E-- ------EVFKVKKSSYSKKIVKLLKKEYKE------------------------------ ----------------------DLEKSK-------------------------------- ------------------------------------------------------------ ---------------------IKTELN-----------S--------------------- -------------------SADNEPPLDKAGHVKDTSLEDGVIISEHGEDEMDMES---- EKEEE------------------------------------------------------K PKA-GGAFS--------------------------------------------------- -------NALSSLNVLRP-----------GEIPDAAFIHAARKKRQMARELGDFTP-HDS E-PGKGRLVR-ED--ENDA-SD-DEDDDEKRRIVFSVKEKSQRQKIAEE--I---GIEGS DDDALV-TGEQDEELSRWEQEQIRKGINIPQVQASQPTEV-NMYYQNTYQTMPYGSSYGI PYSY--SAY-----------------------------GSS-DAKSQKTDNTVPFKTPSN EMTPVTIDLVKKQLKD-R------------------------------------------ ----------------------LDSMKELHKTNRQQHEKHLQSRADSTRAIERLEGSSGG IGERYKFLQEMRGYVQDLLECFSEKVPLINELESAIHQLYKQRASRLVQRRQDDIKDESS EFSSHS-------------------NKALMAPNLDSFGRDRALYQEHAK-RRIAERE--- ---ARR-TRR-RQAREQTGKMADHLEGLSSDDEETSTDITNFNLEK--DRISKESSKVFE DVLESFYSIDCIKSQFEAWRSKYYTSYKHAYIGLCLPKLLNPLIRLQLLTWTPLE----- -------------------------------AKCRDFENMLWFESLLFYGCEERE--QEK DDVDVALLPTIVEKVILPKLTVIAENMWDPFSTT--------------QTSRMVGITLKL INGYPSVVNAENKN-----TQVYLKALLLRMRRTLDDDVFMPLYPKNVLENKNSGPYLFF QRQFWSSVKLLGNFLQWYGIFSNKTLQELSIDGLLNRYILMAFQNSEYGDDSIKKAQNVI NCFPKQWFVNLKGERTISQLENFCRYLVHLADTIYRNSIGCSDVEKRNARENIKQIVKLL ASVRALDHAMSVASDH----------------N------------VKEFKSLIEGK-- >ENSBBBP00000009510 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------MF----- ------------------------------------------------------------ --------------------RKARRVNVRKRNDSEEEE-------RER------------ -------------------------------------------------------DEEQE ----------------------------------------PP------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------P--------------- ------------------------------------------------------------ -----------LL----------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------------PP ------------------------------------------------------------ ------------------------------------------------------------ ----------P------------------------------------------------- ------------------------------------------------------------ --PGT-----------GEEP-----GPGXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX XXXXXXXXXXXXXXXXXXXXXXXXXRASLLS----------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------QDE-DE-EN---------------------------- ---------------------------------------------------------E-- ------EVFKVKKSSYSKKIVKLLKKEYKE------------------------------ ----------------------DLEKSK-------------------------------- ------------------------------------------------------------ ---------------------IKTELN-----------S--------------------- -------------------SADNEPPLDKAGHVKDTSLEDGVIISEHGEDEMDMES---- EKEEE------------------------------------------------------K PKA-GGAFS--------------------------------------------------- -------NALSSLNVLRP-----------GEIPDAAFIHAARKKRQMARELGDFTP-HDS E-PGKGRLVR-ED--ENDA-SD-DEDDDEKRRIVFSVKEKSQRQKIAEE--I---GIEGS DDDALV-TGEQDEELSRWEQEQIRKGINIPQVQASQPTEV-NMYYQNTYQTMPYGSSYGI PYSY--SAY-----------------------------GSS-DAKSQKTDNTVPFKTPSN EMTPVTIDLVKKQLKD-R------------------------------------------ ----------------------LDSMKELHKTNRQQHEKHLQSRADSTRAIERLEGSSGG IGERYKFLQEMRGYVQDLLECFSEKVPLINELESAIHQLYKQRASRLVQRRQDDIKDESS EFSSHS-------------------NKALMAPNLDSFGRDRALYQEHAK-RRIAERE--- ---ARR-TRR-RQAREQTGKMADHLEGLSSDDEETSTDITNFNLEK--DRISKESSKIFE DVLESFYSIDCIKSQFEAWRSKYYTSYKHAYIGLCLPKLLNPLIRLQLLTWTPLE----- -------------------------------AKCRDFENMLWFESLLFYGCEERE--QEK DDVDVALLPTIVEKVILPKLTVIAENMWDPFSTT--------------QTSRMVGITLKL INGYPSVVNAENKN-----TQVYLKALLLRMRRTLDDDVFMPLYPKNVLENKNSGPYLFF QRQFWSSVKLLGNFLQWYGIFSNKTLQELSIDGLLNRYILMAFQNSEYGDDSIKKAQNVI NCFPKQWFVNLKGERTISQLENFCRYLVHLADTIYRNSIGCSDVEKRNARENIKQIVKLL ASVRALDHAMSVASDH----------------N------------VKEFKSLIEGK-- >ENSCHIP00000023854 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------MF----- ------------------------------------------------------------ --------------------RKARRVNVRKRNDSEEEE-------RER------------ -------------------------------------------------------DEEQE ----------------------------------------PP------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------P--------------- ------------------------------------------------------------ -----------LL----------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------------PP ------------------------------------------------------------ ------------------------------------------------------------ ----------P------------------------------------------------- ------------------------------------------------------------ --PGT-----------GEEP-----GPG-------------------------------- ------------------------------PGPGGGGG--------DRA----------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------P-------------------------------------------- ---------------AGESL---------------------------------------- ------------------------------------LGPGP-----------PPPPP--- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------AALTSGTEAGGCLPGGAEPGNGLKPRKR PRENKE--VP-------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------RAS----------------- ------------------LLSF-QDE-DE-ET---------------------------- ---------------------------------------------------------E-- ------EVFKVKKSSYSKKIVKLLKKEYKE------------------------------ ----------------------DLEKSK-------------------------------- ------------------------------------------------------------ ---------------------IKTELN-----------S--------------------- -------------------SADNEPPLDKAGHVKDASLEDGVIISEHGEDEMDMES---- EKEEE------------------------------------------------------K PKA-GGAFS--------------------------------------------------- -------NALSSLNVLRP-----------GEIPDAAFIHAARKKRQMARELGDFTP-HDS E-PGKGRLVR-ED--ENDA-SD-DEDDDEKRRIVFSVKEKSQRQKIAEE--I---GIEGS DDDALV-TGEQDEELSRWEQEQIRKGINIPQVQASQPTEV-NVYYQNTYQTMPYGSSYGV PYSY--SAY-----------------------------GSS-DAKSQKPDNAVPFRTPSN EMPPVTIDLVKKQLKD-R------------------------------------------ ----------------------LDSMKELHKANRQQHEKHLQSRADSTRAIERLEGSSGG IGERYRFLQEMRGYVQDLLECFSEKVPLINELESAIHQLYKQRASRLVQRRQDDIKDESS EFSSHS-------------------NKALMAPNLDSFGRDRALYQEHAK-RRIAERE--- ---ARR-TRR-RQAREQTGKMADHLEGLSSDDEETSTDITNFNLEK--DRISKESSKVFE DVLESFYSIDCIKSQFEAWRSKYYTSYKHAYIGLCLPKLLNPLIRLQLLTWTPLE----- -------------------------------AKCRDFENMLWFESLLFYGCEERE--QEK DDVDVALLPTIVEKVILPKLTVIAENMWDPFSTT--------------QTSRMVGITLKL INGYPSVVNAENKN-----TQIYLKALLLRMRRTLDDDVFMPLYPKNVLENKNSGPYLFF QRQFWSSVKLLGNFLQWYGIFSNKTLQELSIDGLLNRYILMAFQNSEYGDDSIKKAQNVI NCFPKQWFVNLKGERTISQLENFCRYLVHLADTIYRNSIGCSDVEKRNARENIKQIVKLL ASVRALDHAMSVASDH----------------N------------VKEFKSLIEGK-- >ENSOARP00000014297 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------MF----- ------------------------------------------------------------ --------------------RKARRVNVRKRNDSEEEE-------RER------------ -------------------------------------------------------DEEQE ----------------------------------------PP------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------P--------------- ------------------------------------------------------------ -----------LL----------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------------PP ------------------------------------------------------------ ------------------------------------------------------------ ----------P------------------------------------------------- ------------------------------------------------------------ --PGT-----------GEEP-----GPR-------------------------------- ------------------------------PG---------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------PPP--- ------------------------------------------------------------ ---R------------------RRR----------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------XAALTSGTEAGGCLPGGAEPGNGLKPRKR PRENKE--VP-------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------RAS----------------- ------------------LLSF-QDE-DE-ET---------------------------- ---------------------------------------------------------E-- ------EVFKVKKSSYSKKIVKLLKKEYKE------------------------------ ----------------------DLEKSK-------------------------------- ------------------------------------------------------------ ---------------------IKTELN-----------S--------------------- -------------------SADNEPPLDKAGHVKDASLEDGVIISEHGEDEMDMES---- EKEEE------------------------------------------------------K PKA-GGAFS--------------------------------------------------- -------NALSSLNVLRP-----------GEIPDAAFIHAARKKRQMARELGDFTP-HDS E-PGKGRLVR-ED--ENDA-SD-DEDDDEKRRIVFSVKEKSQRQKIAEEIAI---GIEGS DDDALV-TGEQDEELSRWEQEQIRKGINIPQVQASQPTEV-NMYYQNTYQTMPYGSSYGI PYSY--SAY-----------------------------GSS-DAKSQKTDNTVPFKTPSN EMTPVTIDLVKKQLKD-R------------------------------------------ ----------------------LDSMKELHKANRQQHEKHLQSRADSTRAIERLEGSSGG IGERYRFLQEMRGYVQDLLECFSEKVPLINELESAIHQLYKQRASRLVQRRQDDIKDESS EFSSHS-------------------NKALMAPNLDSFGRDRALYQEHAK-RRIAERE--- ---ARR-TRR-RQAREQTGKMADHLEGLSSDDEETSTDITNFNLEKVLDRISKESSKVFE DVLESFYSIDCIKSQFEAWRSKYYTSYKHAYIGLCLPKLLNPLIRLQLLTWTPLE----- -------------------------------AKCRDFENMLWFESLLFYGCEERE--QEK DDVDVALLPTIVEKVILPKLTVIAENMWDPFSTT--------------QTSRMVGITLKL INGYPSVVNAENKN-----TQIYLKALLLRMRRTLDDDVFMPLYPKNVLENKNSGPYLFF QRQFWSSVKLLGNFLQWYGIFSNKTLQELSIDGLLNRYILMAFQNSEYGDDSIKKAQNVI NCFPKQWFVNLKGERTISQLENFCRYLVHLADTIYRNSIGCSDVEKRNARENIKQIVKLL ASVRALDHAMSVASDH----------------N------------VKEFKSLIEGK-- >ENSODEP00000003108 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------MF----- ------------------------------------------------------------ --------------------RKARRVNVRKRNDSEEEE-------RER------------ -------------------------------------------------------DDEQE ----------------------------------------PP------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------P--------------- ------------------------------------------------------------ -----------LL----------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------------PP ------------------------------------------------------------ ------------------------------------------------------------ ----------P-------------------VT---------------------------- ------------------------------------------------------------ ----------------GEEP-----GP--------------------------------- -----------------------------------GGG--------DRT----------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------P-------------------------------------------- ---------------GEESL---------------------------------------- ------------------------------------LGPGP-------------PLP--- ------------------------------------------------------------ ---SA-------------LAPSL------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------GAEAGGGFPGGAEPGNGLKPRKR PRENKE--VP-------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------RAS----------------- ------------------LLSF-QDE-EE-EN---------------------------- ---------------------------------------------------------E-- ------EVFKVKKSSYSKKIVKLLKKEYKE------------------------------ ----------------------DLEKSK-------------------------------- ------------------------------------------------------------ ---------------------IKNELN-----------S--------------------- -------------------SANNEQSLDKTGHVKDTNQEDGVIINDHGEDEMDMES---- EKEEE------------------------------------------------------K PKA-GGAFS--------------------------------------------------- -------NALSSLNVLRP-----------GEIPDAAFIHAARKKRQMARELGDFTP-HDT E-PGKGRLVR-ED--ENDA-SD-DEDDDEKRRIVFSVKEKSQRQKIAEE--I---GIEGS DDDALV-TGEQDEELSRWEQEQIRKGINIPQVQASQPAEV-NMYYQNTYQTMPYGSSYGI PYSY--TAY-----------------------------GSS-DAKSQKTDNTVPFKTPSN EMTPVTIDLVKKQLKD-R------------------------------------------ ----------------------LDSMNELHKTNRQQHEKHLQSRVDSTRAIERLEGSSGG IGERYKFLQEMRGYVQDLLECFSEKVPLINELESSIHQLYKQRASRLVQRRQDDIKDESS EFSSHS-------------------NKALMAPNLDSFGRDRALYQEHAK-RRIAERE--- ---ARR-TRR-RQAREQTGKMADHLEGLSSDDEETSTDITNFNLEK--DRISKESSKVFE DVLESFYSIDCIKSQFEAWRSKYYTSYKDAYIGLCLPKLFNPLIRLQLLTWTPLE----- -------------------------------AKCRDFENMLWFESLLFYGCEERE--QEK DDVDVALLPTIVEKVILPKLTVIAENMWDPFSTT--------------QTSRMVGITLKL INGYPSVVNAENKN-----TQVYLKALLLRMRRTLDDDVFMPLYPKHVLENKNSGPYLFF QRQFWSSVKLLGNFLQWYGIFSNKTLQELSIDGLLNRYILMAFQNSEYGDDSIKKAQNVI NCFPKQWFMNLKGERTISQLENFCRYLVHLADTIYRNSIGCSDVEKRNARENIKQIVKLL ASVRALDHAMSVASDH----------------N------------VKEFKSLIEGK-- >ENSCLAP00000010799 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------MF----- ------------------------------------------------------------ --------------------RKARRVNVRKRNDSEEEE-------RER------------ -------------------------------------------------------DEEQE ----------------------------------------PP------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------P--------------- ------------------------------------------------------------ -----------LL----------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------------PP ------------------------------------------------------------ ------------------------------------------------------------ ----------P-------------------AT---------------------------- ------------------------------------------------------------ ----------------GEEP-----GP--------------------------------- -----------------------------------GGG--------DRP----------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------P-------------------------------------------- ---------------GEESL---------------------------------------- ------------------------------------LGPG-------------------- ------------------------------------------------------------ ----X-------------XAPGL------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------GAEAGGGFLGGAEPGNGLKPRKR PRENKE--VP-------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------RAS----------------- ------------------LLSF-QDE-EE-EN---------------------------- ---------------------------------------------------------E-- ------EVFKVKKSSYSKKIVKLLKKEYKE------------------------------ ----------------------DLEKSK-------------------------------- ------------------------------------------------------------ ---------------------IKNELN-----------S--------------------- -------------------SANNEQSLDKTGHVKDTNQEDGVIINDHGEDEMDMES---- EKEEE------------------------------------------------------K PKA-GGAFS--------------------------------------------------- -------NALSSLNVLRP-----------GEIPDAAFIHAARKKRQMARELGDFTP-HDN E-PGKGRLVR-ED--ENDA-SD-DEDDDEKRRIVFSVKEKSQRQKIAEE--I---GIEGS DDDALV-TGEQDEELSRWEQEQIRKGINIPQVQASQPTEV-NMYYQNTYQTMPYGSSYGI PYSY--TAY-----------------------------GSS-DAKSQKTDNSVPFKTPSN EMTPVTIDLVKKQLKD-R------------------------------------------ ----------------------LDSMKELHKTNRQQHEKHLQSRVDSTRAIERLEGSSGG IGERYKFLQEMRGYVQDLLECFSEKVPLINELESSIHQLYKQRASRLVQRRQDDIKDESS EFSSHS-------------------NKALMAPNLDSFGRDRALYQEHAK-RRIAERE--- ---ARR-TRR-RQAREQTGKMADHLEGLSSDDEETSTDITNFNLEK--DRISKESSKVFE DVLESFYSIDCIKSQFEAWRSKYYTSYKDAYIGLCLPKLFNPLIRLQLLTWTPLE----- -------------------------------AKCRDFENMLWFESLLFYGCEERE--QEK EDVDVALLPTIVEKVILPKLTVIAENMWDPFSTT--------------QTSRMVGITLKL INGYPSVVNAENKN-----TQVYLKALLLRMRRTLDDDVFMPLYPKNVLENKNSGPYLFF QRQFWSSVKLLGNFLQWYGIFSNKTLQELSIDGLLNRYILMAFQNSEYGDDSIKKAQHVI NCFPKQWFVNLKGERTITQLENFCRYLVHLADTIYRNSIGCSDVEKRNARENIKQIVKLL ASVRALDHAMSVASDH----------------N------------VKEFKSLIEGK-- >ENSSSCP00000012819 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------MF----- ------------------------------------------------------------ --------------------RKARRVNVRKRNDSEEEE-------RER------------ -------------------------------------------------------DEEQE ----------------------------------------PP------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------P--------------- ------------------------------------------------------------ -----------LL----------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------------PP ------------------------------------------------------------ ------------------------------------------------------------ ----------P-------------------GT---------------------------- ------------------------------------------------------------ ----------------GEEP-----GPG-------------------------------- ----------------------------------------------DRA----------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------P-------------------------------------------- ---------------GGESL---------------------------------------- ------------------------------------LGPGL------------PPPP--- ------------------------------------------------------------ ---SA-------------LAPGP------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------GTEAGGCFPGGAEPGNGLKPRKR PRENKE--VP-------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------RAS----------------- ------------------LLSF-QDE-DE-EN---------------------------- ---------------------------------------------------------E-- ------EVFKVKKSSYSKKIVKLLKKEYKE------------------------------ ----------------------DLEKSK-------------------------------- ------------------------------------------------------------ ---------------------IKTELN-----------S--------------------- -------------------LADNELPLDKTGHVKDASQEDGVIISEHGEDEMDMES---- EKEEE------------------------------------------------------K PKA-GGTFS--------------------------------------------------- -------NALSSLNVLRP-----------GEIPDAAFIHAARKKRQMARELGDFTP-HDN E-PGKGRLVR-ED--ENDA-SD-DEDDDEKRRIVFSVKEKSQRQKIAEE--I---GIEGS DDDALV-AGEQDEELSRWEQEQIRKGINIPQVQASQPTEV-NMYYPNTYQTMPYGSSYGI PYSY--TAY-----------------------------GSS-DAKSQKTDNTVPFKTPSN EMTPVTIDLVKKQLKD-R------------------------------------------ ----------------------LDSMKELHKTNRQQHEKHLQSRVDSTRAIERLEGSSGG IGERYKFLQEMRGYVQDLLECFSEKVPLINELESAIHQLYKQRASRLVQRRQDDIKDESS EFSSHS-------------------NKALMAPNLDSFGRDRALYQEHAK-RRIAERE--- ---ARR-TRR-RQAREQTGKMADHLEGLSSDDEETSTDITNFNLEK--DRISKESSKVFE DVLESFYSIDCIKSQFEAWRSKYYMSYKDAYIGLCLPKLFNPLIRLQLLTWTPLE----- -------------------------------AKCRDFENMLWFESLLFYGCEERE--QEK DDVDVALLPTIVEKVILPKLTVIAENMWDPFSTT--------------QTSRMVGITLKL INGYPSVVNAENKN-----TQVYLKALLLRMRRTLDDDVFMPLYPKNVLENKNSGPYLFF QRQFWSSVKLLGNFLQWYGIFSNKTLQELSIDGLLNRYILMAFQNSEYGDDSIKKAQNVI NCFPKQWFMNLKGERTISQLENFCRYLVHLADTIYRNSIGCSDVEKRNARENIKQIVKLL ASVRALDHALSVASDH----------------N------------VKEFKSLIEGK-- >ENSTTRP00000002109 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------MF----- ------------------------------------------------------------ --------------------RKARRVNVRKRNDSEEEE-------RER------------ -------------------------------------------------------DEEQE ----------------------------------------PP------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------P--------------- ------------------------------------------------------------ -----------LL----------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------------PP ------------------------------------------------------------ ------------------------------------------------------------ ----------P-------------------GT---------------------------- ------------------------------------------------------------ ----------------GEEP-----GP--------------------------------- -----------------------------------GGG--------DRA----------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------P-------------------------------------------- ---------------GGEPL---------------------------------------- ------------------------------------LGPGL-------------PPP--- ------------------------------------------------------------ ---SA-------------LTSGP------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------GIEAGGCFPGGAEPGNGLKPRKR PRENKE--VP-------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------RAS----------------- ------------------LLSF-QDE-DE-ES---------------------------- ---------------------------------------------------------E-- ------EVFKVKKSSYSKKIVKLLKKEYKE------------------------------ ----------------------DLEKSK-------------------------------- ------------------------------------------------------------ ---------------------IKTEIN-----------S--------------------- -------------------SADSEPPLDKTGHVKDTSQEDGVIISEHGEDEMDMES---- EKEEE------------------------------------------------------K PKA-AGAFS--------------------------------------------------- -------NALSSLNVLRP-----------GEIPDAAFIHAARKKRQMARELGDFTP-HDS E-PGKGRLVR-ED--ENDA-SD-DEDDDEKRRIVFSVKEKSQRQKIAEE--I---GIEGS DDDALV-TGEQDEELSRWEQEQIRKGINIPQVQASQPTEV-NMYYQNTYQTMPYGSSYGI PYSY--TAY-----------------------------GSS-DAKSQKTDNTVPFKTPSN EMTPVTIDLVKKQLKD-R------------------------------------------ ----------------------LDSMKELHKTNRQQHEKHLQSRVDSTRAIERLEGSSGG IGERYKFLQEMRGYVQDLLECFSEKVPLINELESAIHQLYKQRASRLVQRRQDDIKDESS EFSSHS-------------------NKALMAPNLDSFGRDRALYQEHAK-RRIAERE--- ---ARR-TRR-RQAREQTGKMADHLEGLSSDDEETSTDITNFNLEK--DRISKESSKVFE DVLESFCSIDCIKSQFEAWRSKYYTSYKDAYIGLCLPKLFNPLI-LQLLTWTPLE----- -------------------------------AKCRDFENMLWFESLLFYGCEERE--QEK DDVDVALLPTIVEKVILPKLTVIAENMWDPFSTT--------------QTSRMVGITLKL INGYPSVVNAENKN-----TQVYLKALLLRMRRTLDDDVFMPLYPKNVLENKNSGPYLFF QRQFWSSVKLLGNFLQWYGIFSNKTLQELSIDGLLNRYILMAFQNSEYGDDSIKKAQNVI SCFPKQWFMNLKGERTISQLENFCRYLVHLADTIYRNSIGCSDVEKRNARENIKQIVKLL ASVRALDHAMSVASDH----------------N------------VKEFKSLIEGK-- >ENSLAFP00000010677 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------EN---------------------------- ---------------------------------------------------------E-- ------EVFKVKKSSYSKKIVKLLKKEYKE------------------------------ ----------------------DLEKSK-------------------------------- ------------------------------------------------------------ ---------------------IKTELN-----------S--------------------- -------------------SADNEQPLDKTGHVKDPNQEDGVIISEHGEDEMDMES---- EKEEE------------------------------------------------------K PKA-GGAFS--------------------------------------------------- -------NALSSLNVLRP-----------GEIPDAAFIHAARKKRQMARELGDFTP-HDS E-PGKGRLVR-ED--ENDA-SD-DEDDDEKRRIVFSVKEKSQRQKIAEE--I---GIEGS DDEALV-TGDQDEELSRWEQEQIRKGINIPQVQASQPTEV-NMYYQSSYQTMPYGSSYGI PYSY--AAY-----------------------------GSS-DAKSQKSDNTVPFKTPSN EMTPVTIDLVKKQLKD-R------------------------------------------ ----------------------LDSMKELHKTNRQQHEKHLQSRVDSTRAIERLEGSSGG IGERYKFLQEMRGYVQDLLECFSEKVPLINELESAIHQLYKQRASRLVQRRQDDIKDESS EFSSHS-------------------NKALMAPNLDSFGRDRALYQEHAK-RRIAERE--- ---ARR-TRR-RQAREQTGKMADHLEGLSSDDEETSTDITNFNLEK--DRISKESSKIFE DVLESFCSIDCIKSQFEAWRSKYYRSYKDAYIGLCLPKLFNPLIRLQLLTWTPLE----- -------------------------------AKCRDFESMLWFESLLFYGCEERE--QEK DDVDVALLPTIVEKVILPKLTAIAENMWDPFSTT--------------QTSRMVGITLKL INGYSSVVNAENKS-----TQVYLKALLLRMRRTLDDDVFMPLYPKNVLENKNSGPYLFF QRQFWSSVKLLGNFLQWYGIFSNKTLQELSIDGLLNRYILMAFQNSEYGDDSIKKAQNVI NCFPKQWFVNLKGERTISQLENFCRYLVHLADTIYRNSIGCSDVEKRNARENIKQIIKLL ASVRALDHALSVATDH----------------N------------VKEFKSLIEGK-- >ENSHGLP00000016512 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------MF----- ------------------------------------------------------------ --------------------RKARRVNVRKRNDSEEEE-------RER------------ -------------------------------------------------------DEDQE ----------------------------------------PP------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------P--------------- ------------------------------------------------------------ -----------LL----------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------------PP ------------------------------------------------------------ ------------------------------------------------------------ ----------P-------------------TT---------------------------- ------------------------------------------------------------ ----------------GEEP-----GP--------------------------------- -----------------------------------GGG--------DRP----------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------P-------------------------------------------- ---------------GEESL---------------------------------------- ------------------------------------LGPGP-------------PPP--- ------------------------------------------------------------ ---SV-------------LAPGP------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------GAEAGGGFPGGAEPGNGLKPRKR PRENKE--VP-------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------RAS----------------- ------------------LLSF-QDE-EE-EN---------------------------- ---------------------------------------------------------E-- ------EVFKVKKSSYSKKIVKLLKKEYKE------------------------------ ----------------------DLEKSK-------------------------------- ------------------------------------------------------------ ---------------------IKNELN-----------S--------------------- -------------------SADNEQSLDKTGHVKDTNQEDGVII-EHGEDEMDMES---- EKEED------------------------------------------------------K LKG-AGAFS--------------------------------------------------- -------NALSSLNVLRP-----------GEIPDAAFIHAARKKRQMARELGDFTP-HDN E-PGKGRLVR-ED--ENDA-SD-DEDDDEKRRIVFSVKEKSQRQKIAEE--I---GIEGS DDDALV-TGEQDEELSRWEQEQIRKGINIPQVQASQPAEV-NMYYQNTYQTMPYGSSYGI PYSY--TAY-----------------------------GSS-DAKSQKTDNTVPFKTPSN EMTPVTIDLVKKQLKD-R------------------------------------------ ----------------------LDSMKELHRTNRQQHEKHLQSRVDSTRAIERLEGSSGG IGERYKFLQEMRGYVQDLLECFSEKVPLINELESAIHQLYKQRASRLVQRRQDDIKDESS EFSSHS-------------------NKALMAPNLDSFGRDRALYQEHAK-RRIAERE--- ---ARR-TRR-RQAREQTGKMSDHLEGLSSDDEETSTDITNFNLEK--DRISKESSKVFE DVLESFYSIDCIKLQFEAWRSKYYTSYKDAYIGLCLPKLFNPLIRLQLLTWTPLE----- -------------------------------AKCRDFENMLWFESLLFYGCEERE--QEK DDVDVALLPTIVEKVILPKLTVIAENMWDPFSTT--------------QTSRMVGITLKL INGYPSVANAENKN-----TQVYLKALLLRMRRTLDDDVFMPLYPKNVLENKNSGPYLFF QRQFWSSVKLLGNFLQWYGIFSNKTLQELSIDGLLNRYILMAFQNSEYGDDSIKKAQNVM NCFPKQWFVNLKGERTISQLENFCRYLVHLADTIYRNSIGCSDVEKRNARENIKQIVKLL ASVRALDHAMSVASDH----------------N------------VKEFKSLIEGK-- >ENSHGLP00100013953 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------MF----- ------------------------------------------------------------ --------------------RKARRVNVRKRNDSEEEE-------RER------------ -------------------------------------------------------DEDQE ----------------------------------------PPTTGEE------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------R---------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------PGP------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------GAEAGGGFPGGAEPGNGLKPRKR PRENKE--VP-------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------RAS----------------- ------------------LLSF-QDE-EE-EN---------------------------- ---------------------------------------------------------E-- ------EVFKVKKSSYSKKIVKLLKKEYKE------------------------------ ----------------------DLEKSK-------------------------------- ------------------------------------------------------------ ---------------------IKNELN-----------S--------------------- -------------------SADNEQSLDKTGHVKDTNQEDGVII-EHGEDEMDMES---- EKEED------------------------------------------------------K LKG-AGAFS--------------------------------------------------- -------NALSSLNVLRP-----------GEIPDAAFIHAARKKRQMARELGDFTP-HDN E-PGKGRLVR-ED--ENDA-SD-DEDDDEKRRIVFSVKEKSQRQKIAEE--I---GIEGS DDDALV-TGEQDEELSRWEQEQIRKGINIPQVQASQPAEV-NMYYQNTYQTMPYGSSYGI PYSY--TAY-----------------------------GSS-DAKSQKTDNTVPFKTPSN EMTPVTIDLVKKQLKD-R------------------------------------------ ----------------------LDSMKELHRTNRQQHEKHLQSRVDSTRAIERLEGSSGG IGERYKFLQEMRGYVQDLLECFSEKVPLINELESAIHQLYKQRASRLVQRRQDDIKDESS EFSSHS-------------------NKALMAPNLDSFGRDRALYQEHAK-RRIAERE--- ---ARR-TRR-RQAREQTGKMSDHLEGLSSDDEETSTDITNFNLEK--DRISKESSKVFE DVLESFYSIDCIKLQFEAWRSKYYTSYKDAYIGLCLPKLFNPLIRLQLLTWTPLE----- -------------------------------AKCRDFENMLWFESLLFYGCEERE--QEK DDVDVALLPTIVEKVILPKLTVIAENMWDPFSTT--------------QTSRMVGITLKL INGYPSVVNAENKN-----TQVYLKALLLRMRRTLDDDVFMPLYPKNVLENKNSGPYLFF QRQFWSSVKLLGNFLQWYGIFSNKTLQELSIDGLLNRYILMAFQNSEYGDDSIKKAQNVM NCFPKQWFVNLKGERTISQLENFCRYLVHLADTIYRNSIGCSDVEKRNARENIKQIVKLL ASVRALDHAMSVASDH----------------N------------VKEFKSLIEGK-- >ENSPPAP00000022824 M-------------------NSHTQVHARRKNFKFGDEIGKAA----------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------------GNGLKPRKR PRENKE--VP-------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------RAS----------------- ------------------LLSF-QDE-EE-EN---------------------------- ---------------------------------------------------------E-- ------EVFKVKKSSYSKKIVKLLKKEYKE------------------------------ ----------------------DLEKSK-------------------------------- ------------------------------------------------------------ ---------------------IKTELN-----------S--------------------- -------------------SAESEQPLDKTGHVKDTNQEDGVIISEHGEDEMDMES---- EKEEE------------------------------------------------------K PKT-GGAFS--------------------------------------------------- -------NALSSLNVLRP-----------GEIPDAAFIHAARKKRQMARELGDFTP-HDN E-PGKGRLVR-ED--ENDA-SD-DEDDDEKRRIVFSVKEKSQRQKIAEE--I---GIEGS DDDALV-TGEQDEELSRWEQEQIRKGINIPQVQASQPAEV-NMYYQNTYQTMPYGSTYGI PYSY--TAY-----------------------------GSS-DAKSQKTDNTVPFKTPSN EMTPVTIDLVKKQLKD-R------------------------------------------ ----------------------LDSMKELHKTNRQQHEKHLQSRVDSTRAIERLEGSSGG IGERYKFLQEMRGYVQDLLECFSEKVPLINELESAIHQLYKQRASRLVQRRQDDIKDESS EFSSHS-------------------NKALMAPNLDSFGRDRALYQEHAK-RRIAERE--- ---ARR-TRR-RQAREQTGKMADHLEGLSSDDEETSTDITNFNLEK--DRISKESGKVFE DVLESFYSIDCIKSQFEAWRSKYYTSYKDAYIGLCLPKLFNPLIRLQLLTWTPLE----- -------------------------------AKCRDFENMLWFESLLFYGCEERE--QEK DDVDVALLPTIVEKVILPKLTVIAENMWDPFSTT--------------QTSRMVGITLKL INGYPSVVNAENKN-----TQIYLKALLLRMRRTLDDDVFMPLYPKNVLENKNSGPYLFF QRQFWSSVKLLGNFLQWYGIFSNKTLQELSIDGLLNRYILMAFQNSEYGDDSIKKAQNVI NCFPKQWFMNLKGERTISQLENFCRYLVHLADTIYRNSIGCSDVEKRNARENIKQIVKLL ASVRALDHAMSVASDH----------------N------------VKEFKSLIEGK-- >ENSSBOP00000027527 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------M------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------QSAGALARSVGLALSPSLPFFLQESAWEHRRLR A----------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------PPP--- ------------------------------------------------------------ ---SA-------------LTPGL------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------GAEAGGGFPGGAEPGNGLKPRKR PRENKE--VP-------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------RAS----------------- ------------------LLSF-QDE-EE-EN---------------------------- ---------------------------------------------------------E-- ------EVFKVKKSSYSKKIVKLLKKEYKE------------------------------ ----------------------DLEKSK-------------------------------- ------------------------------------------------------------ ---------------------IKTELN-----------S--------------------- -------------------SAESEQPLDKTGHVKDTNQEDGVIISEHGEDEMDMES---- EKEEE------------------------------------------------------K PKT-GGAFS--------------------------------------------------- -------NALSSLNVLRP-----------GEIPDAAFIHAARKKRQMARELGDFTP-HDN E-PGKGRLVR-ED--ENDA-SD-DEDDDEKRRIVFSVKEKSQRQKIAEE--I---GIEGS DDDALV-TGEQDEELSRWEQEQIRKGINIPQVQASQPAEV-NMYYQNTYQTMPYGSSYGI PYSY--TAY-----------------------------GSS-DAKSQKTDNTVPFKTPSN EMTPVTIDLVKKQLKD-R------------------------------------------ ----------------------LDSMKELHKTNRQQHEKHLQSRVDSTRAIERLEGSSGG IGERYKFLQEMRGYVQDLLECFSEKVPLINELESAIHQLYKQRASRLVQRRQDDIKDESS EFSSHS-------------------NKALMAPNLDSFGRDRALYQEHAK-RRIAERE--- ---ARR-TRR-RQAREQTGKMADHLEGLSSDDEETSTDITNFNLEK--DRISKESSKVFE DVLESFYSIDCIKSQFEAWRSKYYTSYKDAYIGLCLPKLFNPLIRLQLLTWTPLE----- -------------------------------AKCRDFENMLWFESLLFYGCEERE--QEK DDVDVALLPTIVEKVILPKLTVIAENMWDPFSTT--------------QTSRMVGITLKL INGYPSVVNAENKN-----TQVYLKALLLRMRRTLDDDVFMPLYPKNVLENKNSGPYLFF QRQFWSSVKLLGNFLQWYGIFSNKTLQELSIDGLLNRYILMAFQNSEYGDDSIKKAQNVI NCFPKQWFMHLKGERTISQLENFCRYLVHLADTIYRNSIGCSDVEKRNARENIKQIVKLL ASVRALDHAMSVASEH----------------N------------VKEFKSLIEGK-- >ENSJJAP00000002423 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------MF----- ------------------------------------------------------------ --------------------RKARRVNVRKRNDSEEEE-------RER------------ -------------------------------------------------------DEEQE ----------------------------------------PP------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------P--------------- ------------------------------------------------------------ -----------LL----------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------------PP ------------------------------------------------------------ ------------------------------------------------------------ ----------P-------------------AT---------------------------- ------------------------------------------------------------ ----------------GEEP-----GP--------------------------------- -----------------------------------GGG--------DRA----------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------P-------------------------------------------- ---------------AGESL---------------------------------------- ------------------------------------AGPAL-------------PPP--- ------------------------------------------------------------ ---SA-------------VTPNL------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------GTEAGGGMPGGAEPGNGLKQRKR PRENKE--VP-------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------RAS----------------- ------------------LLSF-QDE-EE-EN---------------------------- ---------------------------------------------------------E-- ------EVFKVKKSSYSKKIVKLLKKEYKE------------------------------ ----------------------DLEKSK-------------------------------- ------------------------------------------------------------ ---------------------VKTELD-----------S--------------------- -------------------TVGNDQPVDKTGHVKDTNQEDGVLIGEHGEDEMDMES---- EKEEE------------------------------------------------------K PKA-GGAFS--------------------------------------------------- -------NALSSLNVLRP-----------GEIPDAAFIHAARKKRQMARELGDFTP-HDN E-PGKGRLVR-ED--ENDA-SD-DDDDDEKRRIVFSVKEKSQRQKIAEE--I---GIEGS DDDALV-TGEQDEELSRWEQEQIRKGINIPQVQASQPNEV-NMYYQNTYQTMPYGSSYGI PYSY--TAY-----------------------------GSS-DAKSQKTDNTVPFKTPSN EMTPVTIDLVKKQLKD-R------------------------------------------ ----------------------LDSMKELHKTNRQQHEKHLQSRVDSTRAIERLEGSSGG IGERYKFLQEMRGYVQDLLECFSEKVPLINELESAIHQLYKQRASRLVQRRQDDIKDESS EFSSHS-------------------NKALMAPNLDSFGRDRALYQEHAK-RRIAERE--- ---ARR-TRR-RQAREQTGKMADHLEGLSSDDEETSTDITNFNLEK--DRIAKESSKVFE DVLESFYSIDCIKSQFEAWRSKYYTSYKDAYIGLCLPKLFNPLIRLQLLTWTPLE----- -------------------------------AKCRDFENMLWFESLLFYGCEERE--QEK DDVDVALLPTIVEKVILPKLTVIAENMWDPFSTT--------------QTSRMVGITLKL INGYPSVVNAENKN-----TQAYLKALLLRMRRTLDDDVFMPLYPKNVLENKNSGPYLFF QRQFWSSVKLLGNFLQWYGIFSNKTLQELSIDGLLNRYILMAFQNSEYGDDSIKKAQNVI NCFPKQWFMNLKGERTISQLENFCRYLVHLADTIYRNSIGCSDVEKRNARENIKHIVKLL ASVRALDHAMTVASDH----------------N------------VKEFKSLIEGK-- >ENSPPYP00000012688 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------MF----- ------------------------------------------------------------ --------------------RKARRVNVRKRNDSEEEE-------RER------------ -------------------------------------------------------DEEQE ----------------------------------------PP------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------P--------------- ------------------------------------------------------------ -----------LL----------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------------PP ------------------------------------------------------------ ------------------------------------------------------------ ----------P-------------------GT---------------------------- ------------------------------------------------------------ ----------------GEEA-----GP--------------------------------- -----------------------------------GGG--------DRA----------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------P-------------------------------------------- ---------------GGESL---------------------------------------- ------------------------------------LGPGP-------------PPP--- ------------------------------------------------------------ ---SA-------------LTPGL------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------GAEVGGGFPGGAE-GNGLKPRKR PRENKE--VP-------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------RAS----------------- ------------------LLSF--DE-EE-EN---------------------------- ---------------------------------------------------------E-- ------EVFKVKKSSYSKKIVKLLKKEYKE------------------------------ ----------------------DLEKSK-------------------------------- ------------------------------------------------------------ ---------------------IKTELN-----------S--------------------- -------------------SAESEQPLDKTGHVKDTNQEDGVIISEHGEDEMDMES---- EKEEE------------------------------------------------------K PKT-GGAFS--------------------------------------------------- -------NALSSLNVLRP-----------GEIPDAAFIHAARKKRQMARELGDFTP-HDN E-PGKGRLVR-ED--ENDA-SD-DEDDDEKRRIVFSVKEKSQRQKIAEE--I---GIEGS DDDALV-TGEQDEELSRWEQEQIRKGINIPQVQASQPAEV-NMYYQNTYQTMPYGSSYGI PYSY--TAY-----------------------------GSS-DAKSQKTDNTVPFKTPSN EMTPVTIDLVKKQLKD-R------------------------------------------ ----------------------LDSMKELHKTNRQQHEKHLQSRVDSTRAIERLEGSSGG IGERYKFLQEMRGYVQDLLECFSEKVPLINELESAIHQLYKQRASRLVQRRQDDIKDESS EFSSHS-------------------NKALMAPNLDSFGRDRALYQEHAK-RRIAERE--- ---ARR-TRR-RQAREQTGKMADHLEGLSSDDEETSTDITNFNLEK--DRISKESSKVFE DVLESFYSIDCIKSQFEAWRSKYYTSYKDAYIGLCLPKLFNPLIRLQLLTWTPLE----- -------------------------------AKCRDFENMLWFESLLFYGCEERE--QEK DDVDVALLPTIVEKVILPKLTVIAENMWDPFSTT--------------QTSRMVGITLKL INGYPSVVNAENKN-----TQVYLKALLLRMRRTLDDDVFMPLYPKNVLENKNSGPYLFF QRQFWSSVKLLGNFLQWYGIFSNKTLQELSIDGLLNRYILMAFQNSEYGDDSIKKAQNVI NCFPKQWFMNLKGERTISQLENFCRYLVHLADTIYRNSIGCSDVEKRNARENIKQIVKLL ASVRALDHAMSVASDHTSKDTPHFKHGNQISA-------------------------- >ENSCGRP00015017637 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------MILFVTF GTAPGSEGSAPTVLRAARGRRGRREGRRACALGRAWQRASAATPRRRAPASARAPWRSPR SRRPRRLRAGAEARRRRRGCSKARRVNVRKRNDSEEEE-------RER------------ -------------------------------------------------------DEEQE ----------------------------------------PP------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------P--------------- ------------------------------------------------------------ -----------LL----------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------------PP ------------------------------------------------------------ ------------------------------------------------------------ ----------PPRARSRALAAPTGPRGGVAA----------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------GPGPPPQ--P-----QPPPP--- ------------------------------------------------------------ ---SSA-----------HHTPGL------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------GAEAGGGIPGGAEPGNGLKPRKR PRENKE--VP-------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------RAS----------------- ------------------LLSF-QDE-EE-EN---------------------------- ---------------------------------------------------------E-- ------EVFKVKKSSYSKKIVKLLKKEYKE------------------------------ ----------------------DLEKSK-------------------------------- ------------------------------------------------------------ ---------------------IKTELN-----------T--------------------- -------------------TADNDQPLDKACHVKDTNQEDGVVISEHGEDEMDMES---- EKEEE------------------------------------------------------K PKA-AGAFS--------------------------------------------------- -------NALSSLNVLRP-----------GEIPDAAFIHAARKKRQMARELGDFTP-HDN E-PGKGRLVR-ED--ENDA-SD-DEDDDEKRRIVFSVKEKSQRQKIAEE--I---GIEGS DDDALV-TGEQDEELSRWEQEQIRKGINIPQVQASQPTEV-NMYYQNTYQTMPYGASYGI PYSY--TAY-----------------------------GSS-DAKPQKTDSTVPFKTPSN EMAPVTIDLVKKQLKD-R------------------------------------------ ----------------------LDSMKELHKTNRQQHEKHLQSRVDSTRAIERLEGASGG IGERYKFLQEMRGYVQDLLECFSEKVPLINDLESAMHQLYKQRASRLVQRRQDDIKDESS EFSSHS-------------------NKALMAPNLDSFGRDRALYQEHAK-RRIAERE--- ---ARR-TRR-RQAREQTGKMADHLEGLSSDDEETSTDITNFNLEK--DRIVKESSKVFE DVLESFYSIDCIKAQFEAWRSKYYTSYKDAYIGLCLPRLFAPLIRLQLLTWTPLE----- -------------------------------AKCCDFEYMLWFESLLFYGCEERE--QEK DDADVALLPTIVEKVILPKLTVIAENMWDPFSTT--------------QTSRMVGITLKL INGYPSVVNAENKN-----TQVYLKALLLRMRRTLDDDVFMPLYPKNVLENKNSGPYLFF QRQFWSSVKLLGNFLQWYGIFSNKTLQELSIDGLLNRYILMAFQNSEYGDDSIKKAQNVI NCFPKQWFVNLKGERTISQLENFCRYLVHLADTIYRNSIGCSDVEKRNARENIKQIVKLL ASVRALDHAVSVASDH----------------N------------VKELKSLIEGK-- >ENSCGRP00000022051 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------N---------------------------- ---------------------------------------------------------E-- ------EVFKVKKSSYSKKIVKLLKKEYKE------------------------------ ----------------------DLEKSK-------------------------------- ------------------------------------------------------------ ---------------------IKTELN-----------T--------------------- -------------------TADNDQPLDKACHVKDTNQEDGVVISEHGEDEMDMES---- EKEEE------------------------------------------------------K PKA-AGAFS--------------------------------------------------- -------NALSSLNVLRP-----------GEIPDAAFIHAARKKRQMARELGDFTP-HDN E-PGKGRLVR-ED--ENDA-SD-DEDDDEKRRIVFSVKEKSQRQKIAEE--I---GIEGS DDDALV-TGEQDEELSRWEQEQIRKGINIPQVQASQPTEV-NMYYQNTYQTMPYGASYGI PYSY--TAY-----------------------------GSS-DAKPQKTDSTVPFKTPSN EMAPVTIDLVKKQLKD-R------------------------------------------ ----------------------LDSMKELHKTNRQQHEKHLQSRVDSTRAIERLEGASGG IGERYKFLQEMRGYVQDLLECFSEKVPLINDLESAMHQLYKQRASRLVQRRQDDIKDESS EFSSHS-------------------NKALMAPNLDSFGRDRALYQEHAK-RRIAERE--- ---ARR-TRR-RQAREQTGKMADHLEGLSSDDEETSTDITNFNLEK--DRIVKESSKVFE DVLESFYSIDCIKAQFEAWRSKYYTSYKDAYIGLCLPRLFAPLIRLQLLTWTPLE----- -------------------------------AKCCDFEYMLWFESLLFYGCEERE--QEK DDADVALLPTIVEKVILPKLTVIAENMWDPFSTT--------------QTSRMVGITLKL INGYPSVVNAENKN-----TQVYLKALLLRMRRTLDDDVFMPLYPKNVLENKNSGPYLFF QRQFWSSVKLLGNFLQWYGIFSNKTLQELSIDGLLNRYILMAFQNSEYGDDSIKKAQNVI NCFPKQWFVNLKGERTISQLENFCRYLVHLADTIYRNSIGCSDVEKRNARENIKQIVKLL ASVRALDHAVSVASDH----------------N------------VKELKSLIEGK-- >ENSCGRP00001016444 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------MF----- ------------------------------------------------------------ --------------------RKARRVNVRKRNDSEEEE-------RER------------ -------------------------------------------------------DEEQE ----------------------------------------PP------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------P--------------- ------------------------------------------------------------ -----------LL----------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------------PP ------------------------------------------------------------ ------------------------------------------------------------ ----------P-------------------AS---------------------------- ------------------------------------------------------------ ----------------GEEP-----GP--------------------------------- -----------------------------------GGA--------DRA----------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------P-------------------------------------------- ---------------AGESL---------------------------------------- ------------------------------------LGPGPPPQ--P-----QPPPP--- ------------------------------------------------------------ ---SSA-----------HHTPGL------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------GAEAGGGIPGGAEPGNGLKPRKR PRENKE--VP-------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------RAS----------------- ------------------LLSF-QDE-EE-EN---------------------------- ---------------------------------------------------------E-- ------EVFKVKKSSYSKKIVKLLKKEYKE------------------------------ ----------------------DLEKSK-------------------------------- ------------------------------------------------------------ ---------------------IKTELN-----------T--------------------- -------------------TADNDQPLDKACHVKDTNQEDGVVISEHGEDEMDMES---- EKEEE------------------------------------------------------K PKA-AGAFS--------------------------------------------------- -------NALSSLNVLRP-----------GEIPDAAFIHAARKKRQMARELGDFTP-HDN E-PGKGRLVR-ED--ENDA-SD-DEDDDEKRRIVFSVKEKSQRQKIAEE--I---GIEGS DDDALV-TGEQDEELSRWEQEQIRKGINIPQVQASQPTEV-NMYYQNTYQTMPYGASYGI PYSY--TAY-----------------------------GSS-DAKPQKTDSTVPFKTPSN EMAPVTIDLVKKQLKD-R------------------------------------------ ----------------------LDSMKELHKTNRQQHEKHLQSRVDSTRAIERLEGASGG IGERYKFLQEMRGYVQDLLECFSEKVPLINDLESAMHQLYKQRASRLVQRRQDDIKDESS EFSSHS-------------------NKALMAPNLDSFGRDRALYQEHAK-RRIAERE--- ---ARR-TRR-RQAREQTGKMADHLEGLSSDDEETSTDITNFNLEK--DRIVKESSKVFE DVLESFYSIDCIKAQFEAWRSKYYTSYKDAYIGLCLPRLFAPLIRLQLLTWTPLE----- -------------------------------AKCCDFEYMLWFESLLFYGCEERE--QEK DDADVALLPTIVEKVILPKLTVIAENMWDPFSTT--------------QTSRMVGITLKL INGYPSVVNAENKN-----TQVYLKALLLRMRRTLDDDVFMPLYPKNVLENKNSGPYLFF QRQFWSSVKLLGNFLQWYGIFSNKTLQELSIDGLLNRYILMAFQNSEYGDDSIKKAQNVI NCFPKQWFVNLKGERTISQLENFCRYLVHLADTIYRNSIGCSDVEKRNARENIKQIVKLL ASVRALDHAVSVASDH----------------N------------VKELKSLIEGK-- >ENSMAUP00000017444 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------N---------------------------- ---------------------------------------------------------SRD PQPLPPQFFKVKKSSYSKKIVKLLKKEYKE------------------------------ ----------------------DLEKSK-------------------------------- ------------------------------------------------------------ ---------------------IKTELN-----------T--------------------- -------------------TADNEQPLDKACHVKDSNQEDGVVISEHGEDEMDMES---- EKEEE------------------------------------------------------K PKA-GGAFS--------------------------------------------------- -------NALSSLNVLRP-----------GEIPDAAFIHAARKKRQMARELGDFTP-HDN E-PGKGRLVR-ED--ENDA-SD-DEDDDEKRRIVFSVKEKSQRQKIAEE--I---GIEGS DDDALV-TGEQDEELSRWEQEQIRKGINIPQVQASQPAEV-NVYYQSTYQTMPYGASYGV PYSY--TAY-----------------------------GSS-DAKSQKPDNTVPFKTPSN EMAPVTIDLVKKQLKD-R------------------------------------------ ----------------------LDSMKELHKTNRQQHEKHLQSRVDSTRAIERLEGSSGG IGERYKFLQEMRGYVQDLLECFSEKVPLINDLESAIHQLYKQRASRLVQRRQDDIKDESS EFSSHS-------------------NKALMAPNLDSFGRDRALYQEHAK-RRIAERE--- ---ARR-TRR-RQAREQTGKMADHLEGLSSDDEETSTDITNFNLEK--DRILKESSKVFE DVLESFYSIDCIKAQFEAWRSKYYTSYKDAYIGLCLPKLFNPLVRLQLLTWTPLE----- -------------------------------AKCPDFEYMLWFESLLFYGCEERE--QEK DDVDVALLPTIVEKVILPKLTVIAEHMWDPFSTT--------------QTSRMVGITLKL INGYPSVVNAENKN-----TQVYLKALLLRMRRTLDDDVFMPLYPKNVLENKNSGPYLFF QRQFWSSVKLLGNFLQWYGIFSNKTLQELSIDGLLNRYILMAFQNSEYGDDSIKKAQNVI NCFPKQWFVNLKGERTISQLENFCRYLVHLADTIYRNSIGCSDVEKRNARENIKQIVKLL ASVRALDHAVSVASDH----------------N------------VKELKSLIEGK-- >ENSMUSP00000113835 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------MF----- ------------------------------------------------------------ --------------------RKARRVNVRKRNDSEEEE-------RER------------ -------------------------------------------------------DEEQE ----------------------------------------PP------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------P--------------- ------------------------------------------------------------ -----------LL----------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------------PP ------------------------------------------------------------ ------------------------------------------------------------ ----------P-------------------AS---------------------------- ------------------------------------------------------------ ----------------GEEP-----GP--------------------------------- -----------------------------------GGG--------DRA----------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------P-------------------------------------------- ---------------AGESL---------------------------------------- ------------------------------------LGPGPL-----------PPPP--- ------------------------------------------------------------ ---SA-------------HHPGL------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------GAEAGGGISGGAEPGNGLKPRKR PRENKE--VP-------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------RAS----------------- ------------------LLSF-QDE-EE-EN---------------------------- ---------------------------------------------------------E-- ------EVFKVKKSSYSKKIVKLLKKEYKE------------------------------ ----------------------DLEKSK-------------------------------- ------------------------------------------------------------ ---------------------IKTELN-----------T--------------------- -------------------AADSDQPLDKTCHAKDTNPEDGVVISEHGEDEMDMES---- EKEEE------------------------------------------------------K PKA-GGAFS--------------------------------------------------- -------NALSSLNVLRP-----------GEIPDAAFIHAARKKRQLARELGDFTP-HDS E-PGKGRLVR-ED--ENDA-SD-DEDDDEKRRIVFSVKEKSQRQKIAEE--I---GIEGS DDDALV-TGEQDEELSRWEQEQIRKGINIPQVQASQPSEV-NVYYQNTYQTMPYGASYGI PYSY--TAY-----------------------------GSS-DAKSQKTDNTVPFKTPSN EMAPVTIDLVKRQLKD-R------------------------------------------ ----------------------LDSMKELHKTNQQQHEKHLQSRVDSTRAIERLEGSSGG IGERYKFLQEMRGYVQDLLECFSEKVPLINELESAIHQLYKQRASRLVQRRQDDIKDESS EFSSHS-------------------NKALMAPNLDSFGRDRALYQEHAK-RRIAERE--- ---ARR-TRR-RQAREQTGQMADHLEGLSSDDEETSTDITNFNLEK--DRILKESSKVFE DVLESFYSIDCIKAQFEAWRSKYYMSYKDAYIGLCLPKLFNPLIRLQLLTWTPLE----- -------------------------------AKCRDFETMLWFESLLFYGCEDRE--QEK DEADVALLPTIVEKVILPKLTVIAETMWDPFSTT--------------QTSRMVGITMKL INGYPSVVNADNKN-----TQVYLKALLLRMRRTLDDDVFMPLYPKNVLENKNSGPYLFF QRQFWSSVKLLGNFLQWYGIFSNKTLQELSIDGLLNRYILMAFQNSEYGDDSIRKAQNVI NCFPKQWFVNLKGERTISQLENFCRYLVHLADTIYRNSIGCSDVEKRNARENIKQIVKLL ASVRALDHAISVASDH----------------N------------VKEVKSLIEGK-- >MGP_SPRETEiJ_P0044147 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------MF----- ------------------------------------------------------------ --------------------RKARRVNVRKRNDSEEEE-------RER------------ -------------------------------------------------------DEEQE ----------------------------------------PP------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------P--------------- ------------------------------------------------------------ -----------LL----------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------------PP ------------------------------------------------------------ ------------------------------------------------------------ ----------P-------------------AS---------------------------- ------------------------------------------------------------ ----------------GEEP-----GP--------------------------------- -----------------------------------GGG--------DRA----------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------P-------------------------------------------- ---------------AGESL---------------------------------------- ------------------------------------LGPGPL-----------PPPP--- ------------------------------------------------------------ ---SA-------------HHPGL------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------GAEAGGGIPGGAEPGNGLKPRKR PRENKE--VP-------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------RAS----------------- ------------------LLSF-QDE-EE-EN---------------------------- ---------------------------------------------------------E-- ------EVFKVKKSSYSKKIVKLLKKEYKE------------------------------ ----------------------DLEKSK-------------------------------- ------------------------------------------------------------ ---------------------IKTELN-----------T--------------------- -------------------AADSDQPLDKTCHAKDTNPEDGVVISEHGEDEMDMES---- EKEEE------------------------------------------------------K PKA-GGTFS--------------------------------------------------- -------NALSSLNVLRP-----------GEIPDAAFIHAARKKRQLARELGDFTP-HDS E-PGKGRLVR-ED--ENDA-SD-DEDDDEKRRIVFSVKEKSQRQKIAEE--I---GIEGS DDDALV-TGEQDEELSRWEQEQIRKGINIPQVQASQPSEV-NVYYQNTYQTMPYGASYGI PYSY--TAY-----------------------------GSS-DAKSQKTDNTVPFKTPSN EMAPVTIDLVKRQLKD-R------------------------------------------ ----------------------LDSMKELHKTNQQQHEKHLQSRVDSTRAIERLEGSSGG IGERYKFLQEMRGYVQDLLECFSEKVPLINELESAIHQLYKQRASRLVQRRQDDIKDESS EFSSHS-------------------NKALMAPNLDSFGRDRALYQEHAK-RRIAERE--- ---ARR-TRR-RQAREQTGQMADHLEGLSSDDEETSTDITNFNLEK--DRILKESSKVFE DVLESFYSIDCIKAQFEAWRSKYYMSYKDAYIGLCLPKLFNPLIRLQLLTWTPLE----- -------------------------------AKCRDFETMLWFESLLFYGCEERE--QEK DEADVALLPTIVEKVILPKLTVIAETMWDPFSTT--------------QTSRMVGITMKL INGYPSVVNADNKN-----TQVYLKALLLRMRRTLDDDVFMPLYPKNVLENKNSGPYLFF QRQFWSSVKLLGNFLQWYGIFSNKTLQELSIDGLLNRYILMAFQNSEYGDDSIRKAQNVI NCFPKQWFVNLKGERTISQLENFCRYLVHLADTIYRNSIGCSDVEKRNARENIKQIVKLL ASVRALDHAISVASDH----------------N------------VKEVKSLIEGK-- >ENSMSIP00000018972 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------MF----- ------------------------------------------------------------ --------------------RKARRVNVRKRNDSEEEE-------RER------------ -------------------------------------------------------DEEQE ----------------------------------------PP------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------P--------------- ------------------------------------------------------------ -----------LL----------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------------PP ------------------------------------------------------------ ------------------------------------------------------------ ----------P-------------------AS---------------------------- ------------------------------------------------------------ ----------------GEEP-----GP--------------------------------- -----------------------------------GGG--------DRA----------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------P-------------------------------------------- ---------------AGESL---------------------------------------- ------------------------------------LGPGPL-----------PPPP--- ------------------------------------------------------------ ---SA-------------HHPGL------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------GAEAGGGIPGGAEPGNGLKPRKR PRENKE--VP-------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------RAS----------------- ------------------LLSF-QDE-EE-EN---------------------------- ---------------------------------------------------------E-- ------EVFKVKKSSYSKKIVKLLKKEYKE------------------------------ ----------------------DLEKSK-------------------------------- ------------------------------------------------------------ ---------------------IKTELN-----------T--------------------- -------------------AADSDQPLDKTCHAKDTNPEDGVVISEHGEDEMDMES---- EKEEE------------------------------------------------------K PKA-GGAFS--------------------------------------------------- -------NALSSLNVLRP-----------GEIPDAAFIHAARKKRQLARELGDFTP-HDS E-PGKGRLVR-ED--ENDA-SD-DEDDDEKRRIVFSVKEKSQRQKIAEE--I---GIEGS DDDALV-TGEQDEELSRWEQEQIRKGINIPQVQASQPSEV-NVYYQSTYQTMPYGASYGI PYSY--TAY-----------------------------GSS-DAKSQKTDNTVPFKTPSN EMAPVTIDLVKRQLKD-R------------------------------------------ ----------------------LDSMKELHKTNQQQHEKHLQSRVDSTRAIERLEGSSGG IGERYKFLQEMRGYVQDLLECFSEKVPLINELESAIHQLYKQRASRLVQRRQDDIKDESS EFSSHS-------------------NKALMAPNLDSFGRDRALYQEHAK-RRIAERE--- ---ARR-TRR-RQAREQTGQMADHLEGLSSDDEETSTDITNFNLEK--DRILKESSKVFE DVLESFYSIDCIKAQFEAWRSKYYMSYKDAYIGLCLPKLFNPLIRLQLLTWTPLE----- -------------------------------AKCRDFETMLWFESLLFYGCEERE--QEK DEADVALLPTIVEKVILPKLTVIAETMWDPFSTT--------------QTSRMVGITMKL INGYPSVVNADNKN-----TQVYLKALLLRMRRTLDDDVFMPLYPKNVLENKNSGPYLFF QRQFWSSVKLLGNFLQWYGIFSNKTLQELSIDGLLNRYILMAFQNSEYGDDSIRKAQNVI NCFPKQWFVNLKGERTISQLENFCRYLVHLADTIYRNSIGCSDVEKRNARENIKQIVKLL ASVRALDHAISVASDH----------------N------------VKEVKSLIEGK-- >MGP_CAROLIEiJ_P0042248 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------MF----- ------------------------------------------------------------ --------------------RKARRVNVRKRNDSEEEE-------RER------------ -------------------------------------------------------DEEQE ----------------------------------------PP------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------P--------------- ------------------------------------------------------------ -----------LL----------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------------PP ------------------------------------------------------------ ------------------------------------------------------------ ----------P-------------------AS---------------------------- ------------------------------------------------------------ ----------------GEEP-----GP--------------------------------- -----------------------------------GGG--------DRA----------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------P-------------------------------------------- ---------------AGESL---------------------------------------- ------------------------------------LGPGPL-----------PPPP--- ------------------------------------------------------------ ---SA-------------HHPGL------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------GAEAGGGIPGGAEPGNGLKPRKR PRENKE--VP-------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------RAS----------------- ------------------LLSF-QDE-EE-EN---------------------------- ---------------------------------------------------------E-- ------EVFKVKKSSYSKKIVKLLKKEYKE------------------------------ ----------------------DLEKSK-------------------------------- ------------------------------------------------------------ ---------------------IKTELN-----------T--------------------- -------------------AADSDQPLDKTCHAKDANPEDGVVISEHGEDEMDMES---- EKEEE------------------------------------------------------K PKA-GGAFS--------------------------------------------------- -------NALSSLNVLRP-----------GEIPDAAFIHAARKKRQLARELGDFTP-HDS E-PGKGRLVR-ED--ENDA-SD-DEDDDEKRRIVFSVKEKSQRQKIAEE--I---GIEGS DDDALV-TGEQDEELSRWEQEQIRKGINIPQVQASQPTEV-NMYYQNTYQTMPYGASYGI PYSY--TAY-----------------------------GSS-DAKSQKTDNTVPFKTPSN EMAPVTIDLVKKQLKD-R------------------------------------------ ----------------------LDSMKELHKTNQQQHEKHLQSRVDSTRAIERLEGSSGG IGERYKFLQEMRGYVQDLLECFSEKVPLINELESAIHQLYRQRASRLVQRRQDDIKDESS EFSSHS-------------------NKALMAPNLDSFGRDRALYQEHAK-RRIAERE--- ---ARR-TRR-RQAREQTGQMADHLEGLSSDDEETSTDITNFNLEK--DRILKESSKVFE DVLESFYSIDCIKAQFEGWRSKYYMSYKDAYIGLCLPKLFNPLIRLQLLTWTPLE----- -------------------------------AKCRDFETMLWFESLLFYGCEERE--QEK DDADVALLPTIVEKVILPKLTVIAETMWDPFSTT--------------QTSRMVGITMKL INGYPSVVNADNKN-----TQVYLKALLLRMRRTLDDDVFMPLYPKNVLENKNSGPYLFF QRQFWSSVKLLGNFLQWYGIFSNKTLQELSIDGLLNRYILMAFQNSEYGDDSIRKAQNVI NCFPKQWFVNLKGERTISQLENFCRYLVHLADTIYRNSIGCSDVEKRNARENIKQIVKLL ASVRALDHAVSVASDH----------------N------------VKEVKSLIEGK-- >MGP_PahariEiJ_P0029609 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------MF----- ------------------------------------------------------------ --------------------RKARRVNVRKRNDSEEEE-------RER------------ -------------------------------------------------------DEEQE ----------------------------------------PP------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------P--------------- ------------------------------------------------------------ -----------LL----------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------------PP ------------------------------------------------------------ ------------------------------------------------------------ ----------P-------------------AS---------------------------- ------------------------------------------------------------ ----------------GEEP-----GP--------------------------------- -----------------------------------GGG--------DRA----------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------P-------------------------------------------- ---------------AGESL---------------------------------------- ------------------------------------LGPGPP-----------PPPS--- ------------------------------------------------------------ ---SA-------------HHPGL------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------GAEAGGGIPGGAEPGNGLKPRKR PRENKE--VP-------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------RAS----------------- ------------------LLSF-QDE-EE-EN---------------------------- ---------------------------------------------------------E-- ------EVFKVKKSSYSKKIVKLLKKEYKE------------------------------ ----------------------DLEKSK-------------------------------- ------------------------------------------------------------ ---------------------IKTELS-----------T--------------------- -------------------AADSDQPLDKTCHAKDTNPEDGVVVSEHGEDEMDMES---- EKEEE------------------------------------------------------K PKA-GGAFS--------------------------------------------------- -------NALSSLNVLRP-----------GEIPDAAFIHAARKKRQLARELGDFTP-HDS E-PGKGRLVR-ED--ENDA-SD-DEDDDEKRRIVFSVKEKSQRQKIAEE--I---GIEGS DDDALV-TGEQDEELSRWEQEQIRKGINIPQVQASQPTEV-NMYYQNTYQTMPYGASYGI PYSY--TAY-----------------------------GSS-DAKSQKTDNTVPFKTPSN EMAPVTIDLVKKQLKD-R------------------------------------------ ----------------------LDSMKELHKTNRQQHEKHLQSRVDSTRAIERLEGSSGG IGERYKFLQEMRGYVQDLLECFSEKVPLINELESAIHQLYKQRASRLVQRRQDDIKDESS EFSSHS-------------------NKALMAPNLDSFGRDRALYQEHAK-RRIAERE--- ---ARR-TRR-RQAREQTGQMADHLEGLSSDDEETSTDITNFNLEK--DRILKESSKVFE DVLESFYSIDCIKAQFEAWRSKYYMSYKDAYIGLCLPKLFNPLIRLQLLTWTPLE----- -------------------------------AKCRDFETMLWFESLLFYGCEERE--QEK DDVDVALLPTIVEKVILPKLTVIAETMWDPFSTT--------------QTSRMVGITMKL INGYPSVVNAENKN-----TQVYLKALLLRMRRTLDDDVFMPLYPKNVLENKNSGPYLFF QRQFWSSVKLLGNFLQWYGIFSNKTLQELSIDGLLNRYILMAFQNSEYGDDSIRKAQNVI NCFPKQWFVNLKGERTISQLENFCRYLVHLADTIYRNSIGCSDVEKRNARENIKQIVKLL ASVRALDHALSVASDH----------------N------------VKEVKSLMDGK-- >ENSRNOP00000002800 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------MF----- ------------------------------------------------------------ --------------------RKARRVNVRKRNDSEEEE-------RER------------ -------------------------------------------------------DEEQE ----------------------------------------PP------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------P--------------- ------------------------------------------------------------ -----------LL----------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------------PP ------------------------------------------------------------ ------------------------------------------------------------ ----------P-------------------AS---------------------------- ------------------------------------------------------------ ----------------GEEP-----GP--------------------------------- -----------------------------------GGG--------DRA----------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------P-------------------------------------------- ---------------AGESL---------------------------------------- ------------------------------------LGPGP------------PPPP--- ------------------------------------------------------------ ---SA-------------HTPGL------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------GAEAGGGIPGGAEPGNGLKQRKR PRENKE--VP-------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------RAS----------------- ------------------LLSF-QDE-EE-EN---------------------------- ---------------------------------------------------------E-- ------EVFKVKKSSYSKKIVKLLKKEYKE------------------------------ ----------------------DLEKSK-------------------------------- ------------------------------------------------------------ ---------------------IKTELS-----------A--------------------- -------------------AADSDQPLDKMCHAKDTNPEDGVVISEHGEDEMDMES---- EKEEE------------------------------------------------------K PKA-GGAFS--------------------------------------------------- -------NALSSLNVLRP-----------GEIPDAAFIHAARKKRQLARELGDFTP-HDS E-PGKGRLVR-ED--ENDA-SD-DEDDDEKRRIVFSVKEKSQRQKIAEE--I---GIEGS DDDALV-TGEQDEELSRWEQEQIRKGINIPQVQASQPTEV-NMYYQNTYQTMPYGASYGV PYSY--TAY-----------------------------GSS-DAKSQKSDNTVPFKTPSN EAAPITIDLVKKQLKD-R------------------------------------------ ----------------------LDSMKELHKTNRQQHEKHLQSRVDSTRAIERLEGSSGG IGERYKFLQEMRGYVQDLLECFSEKVPLINELESAIHQLYKQRASRLVQRRQDDIKDESS EFSSHS-------------------NKALMAPNLDSFGRDRALYQEHAK-RRIAERE--- ---ARR-TRR-RQAREQTGQMADHLEGLSSDDEETSTDITNFNLER--DRILKESSKVFE DVLESFCSIDCIKAQFEAWRSKYYMSYKDAYIGLCLPKLFNPLIRLQLLTWTPLE----- -------------------------------AKCRDFENMLWFESLLFYGCEERE--QEK DDVDVALLPTIVEKVILPKLTVIAENMWDPFSTT--------------QTSRMVGITLKL INGYPSVVNAENKN-----TQVYLKALLLRMRRTLDDDVFMPLYPKNVLENKNSGPYLFF QRQFWSSVKLLGNFLQWYGIFSNKTLQELSIDGLLNRYILMAFQNSEYGDDSIRKAQNVI NCFPKQWFVNLKGERTISQLENFCRYLVHLADTIYRNSIGCSDVEKRNARENIKQIVKLL ASVRALDHAVSVASDH----------------N------------VKEVKSLIEGK-- >ENSPEMP00000026056 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------MF----- ------------------------------------------------------------ --------------------RKARRVNVRKRNDSEEEE-------RER------------ -------------------------------------------------------DEEQE ----------------------------------------PP------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------P--------------- ------------------------------------------------------------ -----------LL----------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------------PP ------------------------------------------------------------ ------------------------------------------------------------ ----------P-------------------AS---------------------------- ------------------------------------------------------------ ----------------GDEP-----GP--------------------------------- -----------------------------------GGG--------DRA----------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------PXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX XXXXXXXXXXXXXXX--------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------N---------------------------- ---------------------------------------------------------E-- ------EVFKVKKSSYSKKIVKLLKKEYKE------------------------------ ----------------------DLEKSK-------------------------------- ------------------------------------------------------------ ---------------------IKTELS-----------T--------------------- -------------------AADNDQPLDKACHVKDANPEDGVIISEHGEDEMDMES---- EKEEE------------------------------------------------------K PKA-GGTFS--------------------------------------------------- -------NALSSLNVLRP-----------GEIPDAAFIHAARKKRQMARELGDFTP-HDN E-PGKGRLVR-ED--ENDA-SD-DEDDDEKRRIVFSVKEKSQRQKIAEE--I---GIEGS DDDALV-TGEQDEELSRWEQEQIRKGINIPQVQASQPTEV-NMYYQNTYQTMPYGASYGI PYSY--TAY-----------------------------GSS-DAKSQKTDNTVPFKTPSN EMAPVTIDLVKKQLKD-R------------------------------------------ ----------------------LDSMKELHKANRQQHERHLQSRVDSTRAIERLEGSSGG IGERYKFLQEMRGYVQDLLECFSEKVPLINELESAIHQLYKQRASRLVQRRQDDIKDESS EFSSHS-------------------NKALMAPNLDSFGRDRALYQEHAK-RRIAERE--- ---ARR-TRR-RQAREQTGKMADHLEGLSSDDEETSTDITNFNLEK--DRILKESSKVFE DVLESFYSIDCIKAQFEAWRSKYYTSYKDAYIGLCLPKLFNPLIRLQLLTWTPLE----- -------------------------------AKCPDFEYMLWFESLLFYGCEERE--QEK DDVDVALLPTIVEKVILPKLTVIAENMWDPFSTT--------------QTSRMVGITLKL INGYPSVVNAENKN-----TQVYLKALLLRMRRTLDDDVFMPLYPKNVLENKNSGPYLFF QRQFWSSVKLLGNFLQWYGIFSNKTLQELSIDGLLNRYILMAFQNSECGDDSIKKAQNVI NCFPKQWFVNLKGERTISQLENFCRYLVHLADTIYRNSIGCSDVEKRNARENIKQIVKLL ASVRALDHAVSVASDH----------------N------------VKELKSLVEGK-- >ENSMUGP00000014801 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------MF----- ------------------------------------------------------------ --------------------RKARRVNVRKRNDSEEEE-------RER------------ -------------------------------------------------------DEEQE ----------------------------------------PP------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------P--------------- ------------------------------------------------------------ -----------LL----------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------------PP ------------------------------------------------------------ ------------------------------------------------------------ ----------P-------------------AS---------------------------- ------------------------------------------------------------ ----------------GEEP-----CP--------------------------------- -----------------------------------GGG--------DRP----------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------P-------------------------------------------- ---------------AGESL---------------------------------------- ------------------------------------LGPG-------------PPPP--- ------------------------------------------------------------ ---SA-------------HTLGL------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------GAEAGGGIPSGSEPGNGLKPRKR PRENKE--VP-------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------RAS----------------- ------------------LLSF-QDE-EE-EN---------------------------- ---------------------------------------------------------E-- ------EVFKVKKSSYSKKIVKLLKKEYKE------------------------------ ----------------------DLEKSR-------------------------------- ------------------------------------------------------------ ---------------------IKTELN-----------T--------------------- -------------------AADNEQPLDKPCHVKDTNEEDGVIISEHAEDEMDMER---- EREEE------------------------------------------------------R PKA-GGAFS--------------------------------------------------- -------NALSSLNVLRP-----------GEIPDAAFIHAARKKRQMARELGDFTP-HDS E-PGKGRLVR-ED--ENDA-SD-DEDDDEKRRIVFSVKEKSQRQKIAEE--I---GIEGS DDDALV-TAEQDEELSRWEQEQIRKGINIPQVQSSQPTEV-NMYYQNTYQTMPYGASYGI PYSY--TAY-----------------------------GSS-DAKPQKTDNTVPFKTPSN EMAPVTIDLVKKQLKD-R------------------------------------------ ----------------------LDSMKELHKTNRQQHEKHLQSRVDSTRAIERLEGSSGG IGERYKFLQEMRGYVQDLLECFSEKVPLINELESAIHQLYKQRASRLVQRRQDDIKDESS EFSSHS-------------------NKALMAPNLDSFGRDRALYQEHAK-RRIAERE--- ---ARR-TRR-RQAREQTGQMADHLEGLSSDDEETSTDITNFNLEK--DRILKESSKVFE DVLESFYSIDCIKAQFEAWRSKYYTSYKDAYIGLCLPKLFNPLIRLQLLTWTPLE----- -------------------------------AKCRDFENMLWFESLLFYGCEEQE--QEK DDADIALLPTIVEKAILPKLTVIAENMWDPFSTT--------------QTSRMVGITLKL INGYPSVVNAENKN-----TQVYLKALLLRMRRTLDDDVFMPLYPKNVLENKNSGPYLFF QRQFWSSVKLLGNFLQWYGIFSNKTLQELSIDGLLNRYILMAFQNSEYGDDSIRKAQNVI NCFPKQWFVNLKGERTISQLENFCRYLVHLADTIYRNSIGCSDVEKRNARENIKQIVKLL ASVRALDHAVSVASDH----------------N------------VKELKSLIEGK-- >ENSNGAP00000021475 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------MF----- ------------------------------------------------------------ --------------------RKARRVNVRKRNDSEEEE-------RER------------ -------------------------------------------------------DDEQE ----------------------------------------PP------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------P--------------- ------------------------------------------------------------ -----------LL----------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------------PP ------------------------------------------------------------ ------------------------------------------------------------ ----------P-------------------AS---------------------------- ------------------------------------------------------------ ----------------AEES-----GP--------------------------------- -----------------------------------GGG--------DRA----------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------P-------------------------------------------- ---------------GGESL---------------------------------------- ------------------------------------LGPG--------------PPS--- ------------------------------------------------------------ ---SA-------------LTPGV------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------GVEAVGGIPGGAEPGNGLKQRKR PRENKE--VA-------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------RAS----------------- ------------------LLSF-QDE-EE-EN---------------------------- ---------------------------------------------------------E-- ------EVFKVKKSSYSKKIVKLLKKEYKE------------------------------ ----------------------DLEKSK-------------------------------- ------------------------------------------------------------ ---------------------IKTELN-----------S--------------------- -------------------AADNDQPLDKTGHVKDTGQEDGVLISEHGEDEMDMES---- EKEED------------------------------------------------------K PKA-GGTFS--------------------------------------------------- -------NALSSLNVLRP-----------GEIPDAAFIHAARKKRQMARELGDFPP-HDN E-PGKGRLVR-ED--ENDA-SD-DEDDDEKRRIVFSVKEKSQRQKIAEE--I---GIEGS DDDALV-TGEQDEELSRWEQEQIRKGINIPQVQASQPTEV-NVYYQNTYQTMPYGSSYGI PYSY--TAY-----------------------------GSS-DAKSQKTDNTVPFKTPSN EMTPVTIDLVKKQLKD-R------------------------------------------ ----------------------LDSMKELHKTNRQQHEKHLQSRVDSTRAIERLEGSSGG IGERYKFLQEMRGYVQDLLECFSEKVPLINELESAIHQLYKQRASRLVQRRQDDIKDESS EFSSHS-------------------NKALMAPNLDSFGRDRALYQEHAK-RRIAERE--- ---ARR-TRR-RQAREQTGKMADHLEGLSSDDEETSTDTTNFNLEK--DRISKESSKVFE DVLESFYSIDCIKSQFEAWRSKYYMSYKDAYIGLCLPKLFNPLIRLQLLTWTPLD----- -------------------------------AKCRDFENMLWFESLLFYGCEERE--QEK DDVDVALLPTIVEKVILPKLTVIAENMWDPFSTT--------------QTSRMVGITLKL INGYPSVVNAENKN-----TQVYLKALLLRMRRTLDDDVFMPLYPRNVLENKNCGPYLFF QRQFWSSVKLLGNFLQWYGIFSNKTLQELSIDGLLNRYILMAFQNSEYGDDSIKKAQNVI NCFPKQWFVNLKGERTISQLENFCRYLVHLADTIYRNSIGCSDVEKRNARENIKQIVRLL ASVGALDHAVSVASDH----------------N------------VKEFKSLIEGK-- >ENSCPOP00000011193 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------MF----- ------------------------------------------------------------ --------------------RKARRVNVRKRNDS-------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------------R RRRAGAAAVATAAGHWRGAGHWRRRQ---------------------------------- ------------------------------------------------------------ ------------------------------------------------A----------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------P-------------------------------------------- ---------------GEESL---------------------------------------- ------------------------------------LGPGP-------------PPP--- ------------------------------------------------------------ ---SA-------------LGPGL------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------GAEAGSGFPGGAEPGNGLKPRKR PRENKE--VP-------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------RAS----------------- ------------------LLSF-QDE-EE-EN---------------------------- ---------------------------------------------------------E-- ------EVFKVKKSSYSKKIVKLLKKEYKE------------------------------ ----------------------DLEKSK-------------------------------- ------------------------------------------------------------ ---------------------IKNELN-----------S--------------------- -------------------SANNEQSLDKTGHVKDTNQEDGIIINEHGEDEMDMES---- EKEEE------------------------------------------------------K PKA-GGAFS--------------------------------------------------- -------NALSSLNVLRP-----------GEIPDAAFIHAARKKRQMARELGDFTP-HDN E-PGKGRLVR-ED--ENDA-SD-DEDDDEKRRIVFSVKEKSQRQKIAEE--I---GIEGS DDDALV-TGEQDEELSRWEQEQIRKGINIPQVQASQPAEV-NMYYQNTYPTIPYGSSYGI PYSY--TAY-----------------------------GSS-DAKSQKTDNTVPFKTPSN EMTPVTIDLVKKQLKD-R------------------------------------------ ----------------------LDSMKELHKTNRQQHEKHLQSRVDSTRAIERLEGSSGG IGERYKFLQEMRGYVQDLLECFSEKVPLINELESSIHQLYKQRASRLVQRRQDDIKDESS EFSSHS-------------------NKALMAPNLDSFGRDRALYQEHAK-RRIAERE--- ---ARR-TRR-RQAREQTGKMADHLEGLSSDDEETSTDITNFNLEK--DRISKESSKVFE DVLESFYSIDCIKSQFEAWRSKYYMSYKDAYIGLCLPKLFNPLIRLQLLTWTPLE----- -------------------------------AKCRDFENMLWFESLLFYGCEERE--QEK DDVDVALLPTIVEKVILPKLTVIAENMWDPFSTT--------------QTSRMVGITLKL INGYPSVVNAENKN-----TQVYLKALLLRMRRTLDDDVFMPLYPKNVLENKNSGPYLFF QRQFWSSVKLLGNFLQWYGIFSNKTLQELSIDGLLNRYILMAFQNSEYGDDSIKKAQNVI NCFPKQWFMNLKGERTISQLENFCRYLVHLADTIYRNSIGCCDVEKRNARENIKQIVKLL ASVRALDHAMSVASDH----------------N------------VKEFKSLIEGK-- >ENSUMAP00000027486 ------------------------------------------------------------ -----------------------------SS----------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------PPLPS--------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------------PP ------------------------------------------------------------ ------------------------------------------------------------ ----------P------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------PPPP--- ------------------------------------------------------------ ------------------------FAPPGAWR---------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------EVSSQ---------------------------- -RENKE--VP-------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------RAS----------------- ------------------LLSF-QDE-EE-EN---------------------------- ---------------------------------------------------------E-- ------EVFKVKKSSYSKKIVKLLKKEYKE------------------------------ ----------------------DLEKSK-------------------------------- ------------------------------------------------------------ ---------------------IKTELN-----------S--------------------- -------------------SADNEPPLDKAGHVKDTSQEDGVIISEHGEDEMDMES---- EKEEE------------------------------------------------------K PKA-GGAFS--------------------------------------------------- -------NALSSLNVLRP-----------GEIPDAAFIHAARKKRQMARELGDFTP-HDS E-PGKGRLVR-ED--ENDA-SD-DEDDDEKRRIVFSVKEKSQRQKIAEE--I---GIEGS DDDALV-TGEQDEELSRWEQEQIRKGINIPQVQASQPTEV-NMYYQNTYQTMPYGSSYGI PYSY--TAY-----------------------------GSS-DAKSQKTDNTVPFKTPSN EMTPVTIDLVKKQLKD-R------------------------------------------ ----------------------LDSMKELHKTNRQQHEKHLQSRVDSTRAIERLEGSSGG IGERYKFLQEMRGYVQDLLECFSEKVPLINELESAIHQLYKQRASRLVQRRQDDIKDESS EFSSHS-------------------NKALMAPNLDSFGRDRALYQEHAK-RRIAEREESL LS-----------AREQTGKMADHLEGLSSDDEETSTDITNFNLEK--DRISKESSKVFE DVLESFYSIDCIKSQFEAWRSKYYLSYKDAYIGLCLPKLFNPLIRLQLLTWTPLE----- -------------------------------AKCRDFENMLWFESLLFYGCEERE--QEK DDVDVALLPTIVEKVILPKLTVIAENMWDPFSTT--------------QTSRMVGITLKL INGYPSVVNAENKN-----TQVYLKALLLRMRRTLDDDVFMPLYPKNVLENKNSGPYLFF QRQFWSSVKLLGNFLQWYGIFSNKTLQELSIDGLLNRYILMAFQNSEYGDDSIKKAQNVI SCFPKQWFMNLKGERTISQLENFCRYLVHLADTIYRNSIGCSDVEKRNARENIKQIVKLL ASVRALDHAMSVASDH----------------N------------VKEFKSLIEGK-- >ENSMLUP00000005173 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------EN---------------------------- ---------------------------------------------------------E-- ------EVFKVKKSSYSKKIVKLLKKEYKE------------------------------ ----------------------DLEKSK-------------------------------- ------------------------------------------------------------ ---------------------IKTELN-----------S--------------------- -------------------SADNEPPLDKTGHVKDPSQEDGAAVGEHGEDEMDMES---- EKEEE------------------------------------------------------K PKAGGGAFS--------------------------------------------------- -------NALSSLNVLRP-----------GEIPDAAFIHAARKKRQMARELGDFTP-HDS E-PGKGRLVR-ED--ENDA-SD-DEDDDEKRRIVFSVKEKSQRQKIAEE--I---GIEGS DDDALV-AGEQDEELSRWEQEQIRKGINIPQVQASQPAEV-NMYYPNTYPTMPYGSSYGI PYSY--TAY-----------------------------GSS-DGKSQKTDNSAPFKTPSN EMTPVTIDLVKKQLKD-R------------------------------------------ ----------------------LDSMKDVHKANRQQHEKHLQSRVDSTRAIERLEGSSGG IGERYKFLQEMRGYVQDLLECFSEKVPLINELESSIHQLYKQRASRLVQRRQDDIKDESS EFSSHS-------------------NKALMAPNLDSFGRDRALYQEHAK-RRIAERE--- ---ARR-TRR-RQAREQTGKMADHLEGLSSDDEETSTDITNFNLEK--DRISKESSKVFE DVLESFYSIDCIKSQFEAWRSRYYTSYKDAYIGLCLPKLFNPLIRLQLLTWTPLE----- -------------------------------AKCRDFENMLWFESLLFYGCEERE--QER EDVDIALLPTIVEKVILPKLTVIAEHMWDPFSTT--------------QTSRMVGITLKL VNGYPSVANAENKN-----TQVYLKALLLRMRRTLDDDVFMPLYPKNVLENKNSGPYLFF QRQFWSSVKLLGNFLQWYGIFSNKTLQELSIDGLLNRYILMAFQNSEYGDDSIKKAQNVI NCFPKQWFMNLKGERTISQLENFCRYLVHLADTIYRNSIGCSDVEKRNARENIKQIIKLL ASVHALDHAVAVAGEH----------------N------------VKEFKSLVEGKAT >ENSSHAP00000009379 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------MF----- ------------------------------------------------------------ --------------------RKARRVNVRKRNDSEEEE-------RER------------ -------------------------------------------------------DEDQE ----------------------------------------AP------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------A--------------- ------------------------------------------------------------ -----------LL----------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------------PP ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------GGGEESGAG--DRA----------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------P-------------------------------------------- ------------------------------------------------------------ ------------GGELQSSPLAPGPPLLSSSSASLLLGPGA--DAGP------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------GFPASAEQGNGLKPRKR PRENKE--AP-------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------RAS----------------- ------------------LLSF-QDE-EE-ET---------------------------- ---------------------------------------------------------E-- ------EVFKVKKSSYSKKIVKLLKKEYKE------------------------------ ----------------------DLEKSK-------------------------------- ------------------------------------------------------------ ---------------------VKTELN-----------S--------------------- -------------------SADAEQPLDKSGQPKDPNLEDGAIICEHGEEEMEVES---- EKEEE------------------------------------------------------K PKV-GGTFS--------------------------------------------------- -------NALSSLNVLRP-----------GEIPDAAFIHAARKKRQMARELGDFAP-HDH E-PGKGRLVR-ED--ENDA-SD-DDDDDEKRRIVFSVKEKSQRQKIAEE--I---GIEGS DDEALV-TGEQDEELSRWEQEQIRKGINIPQVQASQPAEV-NMYYQNTYQTIPYGSSYGI PYSY--TAY-----------------------------GSS-EAKSQKTDNTVPFKTPSN EMTPVTIDLVKKQLKD-R------------------------------------------ ----------------------LDSLKELHKANRQQHEKHLQSRVDSTRAIERLEGSSGG IGERYKFLQEMRGYVQDLLECFSEKVPLINELESAMHQLYKQRASRLVQRRQDDIKDESS EFSSHS-------------------NKALMAPNLDSFGRDRALYQEHAK-RRIAERE--- ---ARR-TRR-RQAREQTGKMADHLEGLSSDDEETSTDITNFSLER--DRISKESSKIFE DVLESFYSIDCIKSQFEAWRSKYFTSYKDAYIGLCLPKLFNPLIRLQLLTWTPLE----- -------------------------------AKCRDFESMLWFESLLFYGCEEQE--QEK EDVDVALLPTIVEKVILPKL-------------TDCNTFVWEEFSIYKQTSRMVGITLKL TSGYPSVVNAENKN-----TQLYLKALLLRMRRTLDDDVFMPLYPKNILENKNSGPYLFF QRQFWSSVKLLGNFLQWYGIFSNKTLQELSIDGLLNRYILMAFQNSEYGDDSIKKAQHVI NCFPKQWFVNLKGERTICQLENFCRYLVHLADTIYRNSIGCSDVEKRNARENIKQIVKLL ASVRALDHATTVANDH----------------N------------MKELKTLIEGK-- >ENSPCIP00000021601 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------MF----- ------------------------------------------------------------ --------------------RKARRVNVRKRNDSEEEE-------RER------------ -------------------------------------------------------EEDQE ----------------------------------------AP------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------P--------------- ------------------------------------------------------------ -----------LL----------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------------PP ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------GGGEESGAG--DRA----------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------P-------------------------------------------- ------------------------------------------------------------ ------------GGELQSPPLTPGPPLLSSSSASLLLSPGP--DAGP------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------GFPASAEQGNGLKPRKR PRENKE--AP-------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------RAS----------------- ------------------LLSF-QDE-EE-ET---------------------------- ---------------------------------------------------------E-- ------EVFKVKKSSYSKKIVKLLKKEYKE------------------------------ ----------------------DLEKSK-------------------------------- ------------------------------------------------------------ ---------------------VKTELN-----------S--------------------- -------------------SADAEQSLDKAGQPKDPNLEDGAIICEHGEEEMEVES---- EKEEE------------------------------------------------------K PKV-GGTFS--------------------------------------------------- -------NALSSLNVLRP-----------GEIPDAAFIHAARKKRQMARELGDFAP-HEH E-PGKGRLVR-ED--ENDA-SD-DDDDDEKRRIVFSVKEKSQRQKIAEE--I---GIEGS DDEALV-TGEQDEELSRWEQEQIRKGINIPQVQASQPAEV-NMYYQNTYQTMPYGSSYGI PYSY--TAY-----------------------------GSS-EAKSQKTDNTVPFKTPSN EMTPVTIDLVKKQLKD-R------------------------------------------ ----------------------LDSLKELHKANRQQHEKHLQSRVDSTRAIERLEGSSGG IGERYKFLQEMRGYVQDLLECFSEKVPLINELESAMHQLYKQRASRLVQRRQDDIKDESS EFSSHS-------------------NKALMAPNLDSFGRDRALYQEHAK-RRIAERE--- ---ARR-TRR-RQAREQTGKMADHLEGLSSDDEETSTDITNFSLER--DRISKESSKVFE DVLESFYSIDCIKSQFEAWRSKYFTSYKDAYIGLCLPKLFNPLIRLQLLTWTPLE----- -------------------------------AKCRDFESMLWFESLLFYGCEEQE--QEK EDVDVALLPTIVEKVILPKLTGIAENTWDPFSTT--------------QTSRMVGITLKL TSGYPSVVNAENKN-----TQLYLKALLLRMRRTLDDDVFMPLYPKNILENKNSGPYLFF QRQFWSSVKLLGNFLQWYGIFSNKTLQELSIDGLLNRYILMAFQNSEYGDDSIKKAQHVI NCFPKQWFVNLKGERTICQLENFCRYLVHLADTIYRNSIGCSDVEKRNARENIKQIVKLL ASVRALDHAMTVANDH----------------N------------MKELKALIEGK-- >ENSOANP00000011037 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------E-EA---------------------------- ---------------------------------------------------------E-- ------EVFKVKKSSYSKKIVKLLKKEYKE------------------------------ ----------------------DLEKSK-------------------------------- ------------------------------------------------------------ ---------------------VKTDLN-----------S--------------------- -------------------LPDSEPPLTKAGHVKDSSQEDGAGASEHGEEEMEVES---- EKEEE------------------------------------------------------K PKT-GGAFS--------------------------------------------------- -------SALSSLNVLRP-----------GEIPDAAFIHAARKKRQLARELGDFTP-HEN E-AGKGRLVR-ED--ENDA-SD-DEDDDEKRRIVFSVKEKSQRQKIAEE--I---GIEGS DDEALV-AGEQDEELSRWEQEQIRKGINIPQVQASQPAEV-SAYYQNSYQAMPYGSSFAI PYAY--GAF-----------------------------GSS-EAKSPKTDNSVPFKSPSN EMTPVTIDLVKKQLKD-R------------------------------------------ ----------------------LDSMKEVHRANRQQYEKHEQSRADSTRTIERLEGSSGG IGERYRFLQEMRGYVQDLLECFSEKVPLINELESAMHQLYKQRASRLVQRRQDDIKDESS EFSSHSSQSILKPEASSFSLDLSFL---------------RALYQEHAK-RRIAERA--- -----E-TRR-RQAREQLGKMTDHLEGLSSDDEETSTDITNFNLER--DRISRESSKVFE DVLESFYSIDCIKSQFEIWRSKYFTSYKDAYIGLCLPKLFHPLIRLQLLSWTPLE----- -------------------------------AKCRDFESMLWFESLLFYGCEEQE--QEK EDADVALLPTIVEKVILPKLTGIAENTWDPFSTT--------------QTSRMVGITLKL INGYPSVVNAENKN-----TQVYLKALLLRMRRTLDDDVFMPLYPKNILENKNSGPYLFF QRQFWSSVKLLGNFLQWYGILSNKTLQELSIDGLLNRYILMAFQNSECGDDSIKKAQNVI NCFPKQWFVNLKGEKTVSQLENFCRYLVHLADTIYRNSIGCSDVEKRNARENIKQIIKLL ASIRALDHALTVANDH----------------N------------VKELKTLIEGK-- >ENSLCOP00000004434 ------------------------------------------------------------ ------------------------------------------------------------ --------------GRAV------------------------------------------ ---------------------SG----------------PRGAAR--------------- ----------------------------------------------------------SV A--------------------------------------------------GGMF----- ------------------------------------------------------------ --------------------RKARRVNVRKRNDSEEED-------EER------------ -------------------------------------------------------DEE-- ----------------------------------------PP----QEP----------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------PAAAAA--------------------------------------- -----------------------AAGAGGEGPSEA------------------------S MSL--------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------------AAGAGL----- ----------------LPLP-----------------------AGLGALPAP-------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------------GNGLPAAGR P-------------------------KE-----------------------------KKR PRENKE--VP-------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------RAS----------------- ------------------LLSF-QDE-EE-ET---------------------------- ---------------------------------------------------------E-- ------EVFKVKKSSYSKKIVKQLKKEYKE------------------------------ ----------------------DLEKSK-------------------------------- ------------------------------------------------------------ ---------------------VRTEVN-----------S--------------------- -------------------PTDVEAPLEKTGQNKDLGQEDGTANSEHGEEEMEVES---- EKEDE------------------------------------------------------K PKA-GGAFS--------------------------------------------------- -------NALSSLNVLRP-----------GEIPDAAFIHAARKKRQMARELGDFTP-VES E-PGKGRLVR-ED--ENDA-SD-DEDDDEKRRIVFTVKEKSQRQKIAEE--I---GIEGS DDEALV-AGEQDEELSRWEQEQIRKGINIPQVQPSQPAEVNNLYYQNTYQTLSYGSSYGI PYTY--AAY-----------------------------GSS-ETKSQKTDNTVPFKTPSN EMTPVTIDLVKKQLKD-R------------------------------------------ ----------------------LDSMKEMHKANRQQYEKHQQSREDSTKAIERLEGSSGG IGEQYKFLQEMRGYVQDLLECFSEKVPLINELESAMHQLYKQRASRLVQRRQDDIKDESS EFSSHS-------------------NKALMAPNLDSFGRDRVIYQEQVK-RRTAERE--- ---ARR-ARR-RQAREQTGKMADHLEGLSSDDEETSTDITNFNLER--DRILKESSKVFE DVLESFYSIDCIKSQFEAWRSKYFASYKDAYIGLCLPKLFNPLIRLQLLIWTPLE----- -------------------------------GKCRDFETMLWFESLLFYGCEEQE--QVK DDADISLLPTIVERVVLPKLTVISENIWDPFSTT--------------QTSRMVAIVQKL VDGYPSVVNAENKN-----TQMLLKALLLRMRRTLDDDVFMPLYPKNILENKNSGPYLFF QRQFWSSVKLLGNFLQWYGILSNKTLQELSIDGLLNRYILMAFQNSEYGEDSIKKAQSVI ACFPKQWFSNLKGDKTISQLENFCRYLVHLADTIYRNSIGCSDVEKRNAREHIKQIIKLL ASIRALDHAVTVANDH----------------N------------VKELKILIEGK-- >ENSMVIP00005007768 M-----------------FSN--------------------------------------- ------------------------------------------------------------ ----------FSFK---------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------ET---------------------------- ---------------------------------------------------------E-- ------EVFKVKKSSYSKKIVKQLKKEYKE------------------------------ ----------------------DLEKSK-------------------------------- ------------------------------------------------------------ ---------------------VRTEVN-----------S--------------------- -------------------PTAVEAPLEKTGQNKDLGQEDGTANSEHGEEEMEVES---- EKEDE------------------------------------------------------K PKA-GGAFS--------------------------------------------------- -------NALSSLNVLRP-----------GEIPDAAFIHAARKKRQMARELGDFTP-VES E-PGKGRLVR-ED--ENDA-SD-DEDDDEKRRIVFTVKEKSQRQKIAEE--I---GIEGS DDEALV-AGEQDEELSRWEQEQIRKGINIPQVQPSQPAEVNNLYYQNTYQTLSYGSSYGI PYTY--AAY-----------------------------GSS-ETKAQKTDNTVPFKTPSN EMTPVTIDLVKKQLKD-R------------------------------------------ ----------------------LDSMKEMHKANRQQYEKHQQSREDSTKAIERLEGSSGG IGEQYKFLQEMRGYVQDLLECFSEKVPLINELESAMHQLYKQRASRLVQRRQDDIKDESS EFSSHS-------------------NKALMAPNLDSFGRDRVIYQEQVK-RRTAERE--- ---ARR-ARR-RQAREQTGKMADHLEGLSSDDEETSTDITNFNLER--DRILKESSKVFE DVLESFYSIDCIKSQFEAWRSKYFASYKDAYIGLCLPKLFNPLIRLQLLIWTPLE----- -------------------------------GKCRDFETMLWFESLLFYGCEEQE--QVK DDADISLLPTIVERVVLPKLTVISENIWDPFSTT--------------QTSRMVAIVQKL VDGYPSVVNAENKN-----TQMLLKALLLRMRRTLDDDVFMPLYPKNILENKNSGPYLFF QRQFWSSVKLLGNFLQWYGILSNKTLQELSIDGLLNRYILMAFQNSEYGEDSIKKAQSVI ACFPKQWFSNLKGDKTISQLENFCRYLVHLADTIYRNSIGCSDVEKRNAREHIKQIIKLL ASIRALDHAVTVANDH----------------N------------VKELKILIEGK-- >ENSCPUP00000018338 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ DGGRGRCSGRRGGDHAEGAGPGPRRGLAGAGGAGAGTGAARRGGSLSSVPVGGMF----- ------------------------------------------------------------ --------------------RKARRVNVRKRNDSEEED-------EER------------ -------------------------------------------------------DEE-- ----------------------------------------PP----QEPAAPAAGGEGPG EASMALAAA--------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------GSGLLPLPAGCVPLALPGSPAAFACAASYGAALGLGLGL VGGDRAGLMFSIFSFK-------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------ET---------------------------- ---------------------------------------------------------E-- ------EVFKVKKSSYSKKIVKQLKKEYKE------------------------------ ----------------------DLEKSK-------------------------------- ------------------------------------------------------------ ---------------------VRTEVN-----------S--------------------- -------------------PTDVEPPLEKTGQIKDIGQEDGTANSEHGEEEMEVES---- EKEEE------------------------------------------------------K PKA-GGAFS--------------------------------------------------- -------SALSSLNVLRP-----------GEIPDAAFIHAARKKRQMARELGDFTP-VDS E-PGKGRLVR-ED--ENDA-SD-DEDDDEKRRIVFAVKEKSQRQKIAEE--I---GIEGS DDEALV-AGEQDEELSRWEQEQIRKGINIPQVQPSQPAEVNNLYYQNTYQTLSYGSSYGI PYTY--AAY-----------------------------GSS-ETKSQKTDNTVPFKTPSN EMTPVTIDLVKKQLKD-R------------------------------------------ ----------------------LDSMKELHKANRQQYEKHQQSREDSTKAIERLEGSSGG IGEQYKFLQEMRGYVQDLLECFSEKVPLINELESAMHQLYKQRASRLVQRRQDDIKDESS EFSSHS-------------------NKALMAPNLESFGRDRVIYQEQVK-RRTAERE--- ---ARR-TRR-RQAREQTGKMADHLEGLSSDDEETSTDITNFNMER--DRILKESSKVFE DVLESFYSIDCIKSQFEAWRSKYFASYKDAYIGLCLPKLFNPLIRLQLLIWTPLE----- -------------------------------GKCRDFETMLWFESLLFYGCEEQE--QVK DDADISLLPTIVERVVLPKLTVISENIWDPFSTT--------------QTSRMVAIVQKL VDGYPSVVNAENKN-----TQMLLKALLLRMRRTLDDDVFMPLYPKNILENKNSGPYLFF QRQFWSSVKLLGNFLQWYGILSNKTLQELSIDGLLNRYILMAFQNSEYGEDSIKKAQSVI ACFPKQWFANLKGDKTISQLENFCRYLVHLADTIYRNSIGCSDVEKRNAREHIKQIIKLL ASIRALDHAVTVANDH----------------N------------VKELKILIEGK-- >ENSTGUP00000013981 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --QHYDEEEEEDDEDDEDSEEDSEDDEDMQDMDEGGH----------------------- --GGDRAGSGPWLA---------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------PAAC------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------------PP ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------P-------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------PPP--- ----QPQQ---------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------------GNGLPAAGR P-------------------------KE-----------------------------KKR SRENKE--VP-------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------RAS----------------- ------------------LLSF-QDE-EE-ET---------------------------- ---------------------------------------------------------E-- ------EVFKVKKSSYSKKIVKQLKKEYKE------------------------------ ----------------------DLEKSK-------------------------------- ------------------------------------------------------------ ---------------------VRTEVN-----------S--------------------- -------------------PTDVEAPLEKIGQNKDVGQEDGTANSEHGEEEMEVES---- EKEEE------------------------------------------------------K PKA-GGAFS--------------------------------------------------- -------SALSSLNVLRP-----------GEIPDAAFIHAARKKRQMARELGDFTP-VDS E-PGKSRLVR-ED--ENDA-SD-DEDDDEKRRIVFTVKEKSQRQKIAEE--I---GIEGS DDEALV-AGEQDEELSRWEQEQIRKGINIPQVQPSQPAEVNNVYYQNTYQTLSYGSSYGI PYTY--AAY-----------------------------GSS-ETKSQKTDNTVPFKTPSN EMTPVTIDLVKKQLKD-R------------------------------------------ ----------------------LDSMKEMHKANRQQYEKHQQSQEDSTKAIERLEGSSGG IGERYKFLQEMRGYVQDLLECFSEKVPLINELESAMHQLYKQRASRLVQRRQDDIKDESS EFSSHS-------------------NKALMAPNLDSFGRDRVIYQEQVK-RRTAERE--- ---ARR-ARR-RQAREQTGKMADHLEGLSSDDEETSTDITNFNLER--DRILKESSKVFE DVLESFYSIDCIKSQFEAWRSKYFASYKDAYIGLCLPKLFNPLIRLQLLTWTPLE----- -------------------------------GKCRDFETMLWFESLLFYGCEEQE--QVK DDADISLLPTIVERVVLPKLTVISENIWDPFSTT--------------QTSRMVAIVQKL IDGYPSVVNAENKN-----TQMLLKALLLRMRRTLDDDVFMPLYPKNILENKNSGPYLFF QRQFWSSVKLLGNFLQWYGILSNKTLQELSIDGLLNRYILMAFQNSEYGEDSIKKAQSVI ACFPKQWFTNLTGDKTISQLENFCRYLVHLADTIYRNSIGCSDVEKRNAREHIKQIVKLL ASIRALDHAVTVANDH----------------N------------VKEFKILIEGK-- >ENSZALP00000019428 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------MF----- ------------------------------------------------------------ --------------------RKARRVNVRKRNDSEEED-------EER------------ -------------------------------------------------------DEE-- ----------------------------------------PP----QEPA---------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------PA-------------- ----AGTAGEGPSEASVPLASGAGLLPLPAGCVPLALPGSPAAFACAASYGAALGLGLGM MGGDRAGL---------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------GALPAPGVL--RPP ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------A-------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------PPP--- ----QPQQ---------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------------GNGLPVAGR P-------------------------KE-----------------------------KKK SRENKE--VP-------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------RAS----------------- ------------------LLSF-QDE-EE-ET---------------------------- ---------------------------------------------------------E-- ------EVFKVKKSSYSKKIVKQLKKEYKE------------------------------ ----------------------DLEKSK-------------------------------- ------------------------------------------------------------ ---------------------VRTEAN-----------S--------------------- -------------------PTDAEAPPEKVGQNKDIGQEDGTANSEHGEEEMEVES---- EKEEE------------------------------------------------------K PKA-GGAFS--------------------------------------------------- -------SALSSLNVLRP-----------GEIPDAAFIHAARKKRQMARELGDFTP-VDS E-PGKGRLVR-ED--ENDA-SD-DEDDDEKRRIVFTVKEKSQRQKIAEE--I---GIEGS DDEALV-AGEQDEELSRWEQEQIRKGINIPQVQPSQPAEVNNVYYQNTYQTLSYGSSYGI PYTY--AAY-----------------------------GSS-ETKSQKTDNTVPFKTPSN EMTPVTIDLVKKQLKD-R------------------------------------------ ----------------------LDSMKEMHKANRQQYEKHQQSQEDSTKAIERLEGSSGG IGERYKFLQEMRGYVQDLLECFSEKVPLINELESAMHQLYKQRASRLVQRRQDDIKDESS EFSSHS-------------------NKALMAPNLDSFGRDRVIYQEQVK-RRTAERE--- ---ARR-ARR-RQAREQTGKMADHLEGLSSDDEETSTDITNFNLER--DRILKESSKVFE DVLESFYSIDCIKSQFEAWRSKYFASYKDAYIGLCLPKLFNPLIRLQLLTWTPLE----- -------------------------------GKCRDFETMLWFESLLFYGCEEQE--QVK DDADISLLPTIVERVVLPKLTVISENIWDPFSTT--------------QTSRMVAIVQKL IDGYPSVVNAENKN-----TQMLLKALLLRMRRTLDDDVFMPLYPKNILENKNSGPYLFF QRQFWSSVKLLGNFLQWYGILSNKTLQELSIDGLLNRYILMAFQNSEYGEDSIKKAQSVI ACFPKQWFTNLTGDKTISQLENFCRYLVHLADTIYRNSIGCSDVEKRNAREHIKQIIKLL ASVRALDHAVTVANDH----------------N------------VKEFKILIEGK-- >ENSJHYP00000012362 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------MF----- ------------------------------------------------------------ --------------------RKARRVNVRKRNDSEEED-------EER------------ -------------------------------------------------------DEE-- ----------------------------------------PP----QEPA---------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------PV-------------- ----AGTAGEGPSEASVPLASGAGLLPLPAGCVPLALPGSPAAFACAASYGAALGLGLGL MGGDRAGL---------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------GTLPAPGVL--RPP ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------A-------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------PPP--- ----QPQQ---------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------------GNGLPVAGR P-------------------------KE-----------------------------KKK SRENKE--VP-------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------RAS----------------- ------------------LLSF-QDE-EE-ET---------------------------- ---------------------------------------------------------E-- ------EVFKVKKSSYSKKIVKQLKKEYKE------------------------------ ----------------------DLEKSK-------------------------------- ------------------------------------------------------------ ---------------------VRTEAN-----------S--------------------- -------------------PTDAEAPPEKVGQNKDIGQEDGTANSEHGEEEMEVES---- EKEEE------------------------------------------------------K PKA-GGAFS--------------------------------------------------- -------SALSSLNVLRP-----------GEIPDAAFIHAARKKRQMARELGDFTP-VDS E-PGKGRLVR-ED--ENDA-SD-DEDDDEKRRIVFTVKEKSQRQKIAEE--I---GIEGS DDEALV-AGEQDEELSRWEQEQIRKGINIPQVQPSQPAEVNNVYYQNTYQTLSYGSSYGI PYTY--AAY-----------------------------GSS-ETKSQKTDNTVPFKTPSN EMTPVTIDLVKKQLKD-R------------------------------------------ ----------------------LDSMKEMHKANRQQYEKHQQSQEDSTKAIERLEGSSGG IGERYKFLQEMRGYVQDLLECFSEKVPLINELESAMHQLYKQRASRLVQRRQDDIKDESS EFSSHS-------------------NKALMAPNLDSFGRDRVIYQEQVK-RRTAERE--- ---ARR-ARR-RQAREQTGKMADHLEGLSSDDEETSTDITNFNLER--DRILKESSKVFE DVLESFYSIDCIKSQFEAWRSKYFASYKDAYIGLCLPKLFNPLIRLQLLTWTPLE----- -------------------------------GKCRDFETMLWFESLLFYGCEEQE--QVK DDADISLLPTIVERVVLPKLTVISENIWDPFSTT--------------QTSRMVAIVQKL IDGYPSVVNAENKN-----TQMLLKALLLRMRRTLDDDVFMPLYPKNILENKNSGPYLFF QRQFWSSVKLLGNFLQWYGILSNKTLQELSIDGLLNRYILMAFQNSEYGEDSIKKAQSVI ACFPKQWFTNLTGDKTISQLENFCRYLVHLADTIYRNSIGCSDVEKRNAREHIKQIIKLL ASVRALDHAVTVANDH----------------N------------VKEFKILIEGK-- >ENSSCAP00000023268 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------------GL MGGDRASL---------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------GALPAPA------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------E-----------------------------KKR SRENKE--VP-------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------RAS----------------- ------------------LLSF-QDE-EE-ET---------------------------- ---------------------------------------------------------E-- ------EVFKVKKSSYSKKIVKQLKKEYKE------------------------------ ----------------------DLEKSK-------------------------------- ------------------------------------------------------------ ---------------------VRTEAN-----------S--------------------- -------------------PTDVEAPPEKIGQNKDIGQEDGTANSEHGEEEMEVES---- EKEEE------------------------------------------------------K PKA-GGAFS--------------------------------------------------- -------SALSSLNVLRP-----------GEIPDAAFIHAARKKRQMARELGDFTP-VDS E-PGKGRLVR-ED--ENDA-SD-DEDDDEKRRIVFTVKEKSQRQKIAEE--I---GIEGS DDEALV-AGEQDEELSRWEQEQIRKGINIPQVQPSQPAEVNNVYYQNTYQTLSYGSSYGI PYTY--AAY-----------------------------GSS-ETKSQKTDNTVPFKTPSN EMTPVTIDLVKKQLKD-R------------------------------------------ ----------------------LDSMKEMHKANRQQYEKHQQSQEDSTKAIERLEGSSGG IGERYKFLQEMRGYVQDLLECFSEKVPLINELESAMHQLYKQRASRLVQRRQDDIKDESS EFSSHS-------------------NKALMAPNLDSFGRDRVIYQEQVK-RRTAERE--- ---ARR-ARR-RQAREQTGKMADHLEGLSSDDEETSTDITNFNLER--DRILKESSKVFE DVLESFYSIDCIKSQFEAWRSKYFASYKDAYIGLCLPKLFNPLIRLQLLTWTPLE----- -------------------------------GKCRDFETMLWFESLLFYGCEEQE--QVK DDADISLLPTIVERVVLPKLTVISENIWDPFSTT--------------QTSRMVAIVQKL IDGYPSVVNAENKN-----TQMLLKALLLRMRRTLDDDVFMPLYPKNILENKNSGPYLFF QRQFWSSVKLLGNFLQWYGILSNKTLQELSIDGLLNRYILMAFQNSEYGEDSIKKAQSVI ACFPKQWFTNLTGDKTISQLENFCRYLVHLADTIYRNSIGCSDVEKRNAREHIKQIIKLL ASIRALDHAVTVANDH----------------N------------VKEFKILIEGK-- >ENSPMJP00000015850 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------MF----- ------------------------------------------------------------ --------------------RKARRVNVRKRNDSEEED-------EER------------ -------------------------------------------------------DEE-- ----------------------------------------PP----QEPA---------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------PA-------------- ----VGAAGEGPSEAAMPLASGAGLLPLPAGCVPLSLPGSPAAFACAASYGAALGLGLGL MGSDRAGL---------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------GVLPAPAVL--RPP ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------P-------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------PPP--- ----QPQQ---------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------------GNGLPAAGR P-------------------------KE-----------------------------KKR SRENKE--VP-------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------RAS----------------- ------------------LLSF-QDE-EE-ET---------------------------- ---------------------------------------------------------E-- ------EVFKVKKSSYSKKIVKQLKKEYKE------------------------------ ----------------------DLEKSK-------------------------------- ------------------------------------------------------------ ---------------------VRTEVN-----------S--------------------- -------------------PTDVEAPLEKTGQNKDIGQEDGTANSEHGEEEMEVES---- EKEEE------------------------------------------------------K PKA-GGAFS--------------------------------------------------- -------SALSSLNVLRP-----------GEIPDAAFIHAARKKRQMARELGDFTP-VDS E-PGKSRLVR-ED--ENDA-SD-DEDDDEKRRIVFTVKEKSQRQKIAEE--I---GIEGS DDEALV-AGEQDEELSRWEQEQIRKGINIPQVQPSQPAEVNNVYYQNTYQTLSYGSSYGI PYTY--AAY-----------------------------GSS-ENKSQKTDNTVPFKTPSN EMTPVTIDLVKKQLKD-R------------------------------------------ ----------------------LDSMKEIHKANRQQYEKHQQSQEDSTKAIERLEGSSGG IGERYKFLQEMRGYVQDLLECFSEKVPLINELESAMHQLYKQRASRLVQRRQDDIKDESS EFSSHS-------------------NKALMAPNLDSFGRDRVIYQEQVK-RRTAERE--- ---ARR-ARR-RQAREQTGKMADHLEGLSSDDEETSTDITNFNLER--DRILKESSKVFE DVLESFYSIDCIKSQFEAWRSKYFASYKDAYIGLCLPKLFNPLIRLQLLTWTPLE----- -------------------------------GKCRDFETMLWFESLLFYGCEEQE--QVK DDADISLLPTIVERVVLPKLTVISENIWDPFSTT--------------QTSRMVAIVQKL IDGYPSVVNAENKN-----TQMLLKALLLRMRRTLDDDVFMPLYPKNILENKNSGPYLFF QRQFWSSVKLLGNFLQWYGILSNKTLQELSIDGLLNRYILMAFQNSEYGEDSIKKAQSVI ACFPKQWFTNLTGDKTISQLENFCRYLVHLADTIYRNSIGSSDVEKRNAREHIKQIIKLL ASIRALDHAITVANDH----------------N------------VKEFKILIEGK-- >ENSCCEP00000004320 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -RENKE--VP-------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------RAS----------------- ------------------LLSF-QDE-EE-ET---------------------------- ---------------------------------------------------------E-- ------EVFKVKKSSYSKKIVKQLKKEYKE------------------------------ ----------------------DLEKSK-------------------------------- ------------------------------------------------------------ ---------------------VRTEVN-----------S--------------------- -------------------PTDVEAPLEKTGQNKDIGQEDGTANSEHGEEEMEVES---- EKEEE------------------------------------------------------K PKA-GGAFS--------------------------------------------------- -------SALSSLNVLRP-----------GEIPDAAFIHAARKKRQMARELGDFTP-VDS E-PGKSRLVR-ED--ENDA-SD-DEDDDEKRRIVFTVKEKSQRQKIAEE--I---GIEGS DDEALV-AGEQDEELSRWEQEQIRKGINIPQVQPSQPAEVNNVYYQNTYQTLSYGSSYGI PYTY--AAY-----------------------------GSS-ENKSQKTDNTVPFKTPSN EMTPVTIDLVKKQLKD-R------------------------------------------ ----------------------LDSMKEIHKANRQQYEKHQQSQEDSTKAIERLEGSSGG IGERYKFLQEMRGYVQDLLECFSEKVPLINELESAMHQLYKQRASRLVQRRQDDIKDESS EFSSHS-------------------NKALMAPNLDSFGRDRVIYQEQVK-RRTAERE--- ---ARR-ARR-RQAREQTGKMADHLEGLSSDDEETSTDITNFNLER--DRILKESSKVFE DVLESFYSIDCIKSQFEAWRSKYFASYKDAYIGLCLPKLFNPLIRLQLLTWTPLE----- -------------------------------GKCRDFETMLWFESLLFYGCEEQE--QVK DDADISLLPTIVERVVLPKLTVISENIWDPFSTT--------------QTSRMVAIVQKL IDGYPSVVNAENKN-----TQMLLKALLLRMRRTLDDDVFMPLYPKNILENKNSGPYLFF QRQFWSSVKLLGNFLQWYGILSNKTLQELSIDGLLNRYILMAFQNSEYGEDSIKKAQSVI ACFPKQWFTNLTGDKTISQLENFCRYLVHLADTIYRNSIGSSDVEKRN---HIKQIIKLL ASVRALDHAITVANDH----------------N------------VKEFKILIEGK-- >ENSLSDP00000002704 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------MF----- ------------------------------------------------------------ --------------------RKARRVNVRKRNDSEEED-------EER------------ -------------------------------------------------------DEE-- ----------------------------------------PP----QEPAA--------- ------AAAGE------------------------------------------------G PSE--------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------ASAP---------------------- ------------------------------------------------------------ --------------------------------------------P--------------- ---------------------GAGLLPLPAGCVPLALPGSPAAFACAASYGAALGLGLGL MGGDRAGL---------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------GALAAPAAL--RPP ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----PQQ---------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------------GNGLPAAGR P-------------------------KE-----------------------------KKR SRENKE--VP-------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------RAS----------------- ------------------LLSF-QDE-EE-ET---------------------------- ---------------------------------------------------------E-- ------EVFKVKKSSYSKKIVKQLKKEYKE------------------------------ ----------------------DLEKSK-------------------------------- ------------------------------------------------------------ ---------------------VRTEVN-----------S--------------------- -------------------PTDVEAPLEKIGQNKDIGQEDGTANSEHGEEEMEVES---- EKEEE------------------------------------------------------K PKA-GGAFS--------------------------------------------------- -------SALSSLNVLRP-----------GEIPDAAFIHAARKKRQMARELGDFTP-VDS E-PGKSRLVR-ED--ENDA-SD-DEDDDEKRRIVFTVKEKSQRQKIAEE--I---GIEGS DDEALV-AGEQDEELSRWEQEQIRKGINIPQVQPSQPAEVNNVYYQNTYQTLSYGSSYGI PYTY--AAY-----------------------------GSS-ETKSQKTDNTVPFKTPSN EMTPVTIDLVKKQLKD-R------------------------------------------ ----------------------LDSMKEMHKANRQQYEKHQQSQEDSTKAIERLEGSSGG IGERYKFLQEMRGYVQDLLECFSEKVPLINELESAMHQLYKQRASRLVQRRQDDIKDESS EFSSHS-------------------NKALMAPNLDSFGRDRVIYQEQVK-RRTAERE--- ---ARR-ARR-RQAREQTGKMADHLEGLSSDDEETSTDITNFNLER--DRILKESSKVFE DVLESFYSIDCIKSQFEAWRSKYFASYKDAYIGLCLPKLFNPLIRLQLLTWTPLE----- -------------------------------GKCRDFETMLWFESLLFYGCEEQE--QVK DDADISLLPTIVERVVLPKLTVISENIWDPFSTT--------------QTSRMVAIVQKL IDGYPSVVNAENKN-----TQMLLKALLLRMRRTLDDDVFMPLYPKNILENKNSGPYLFF QRQFWSSVKLLGNFLQWYGILSNKTLQELSIDGLLNRYILMAFQNSEYGEDSIKKAQSVI ACFPKQWFTNLTGDKTISQLENFCRYLVHLADTIYRNSIGCSDVEKRNAREHIKQIVKLL ASIRALDHAVTVANDH----------------N------------VKEFKILIEGK-- >ENSFALP00000006587 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------PPP-------------------- ---P-------------------------PPPPPPPPPPPPPPPPPPPPPPPPPPPPPPP PPPPPPP--------------PPP-------------------PP--------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------------PP ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------P-------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------PPP--- ----QPQQ---------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------------GNGLPAAGR P-------------------------KE-----------------------------KKR SRENKE--VP-------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------RAS----------------- ------------------LLSF-QDE-EE-ET---------------------------- ---------------------------------------------------------E-- ------EVFKVKKSSYSKKIVKQLKKEYKE------------------------------ ----------------------DLEKSK-------------------------------- ------------------------------------------------------------ ---------------------VRTEVN-----------S--------------------- -------------------PTDVEAPLEKTGQNKDIGQEDGTANSEHGEEEMEVES---- EKEEE------------------------------------------------------K PKA-GGAFS--------------------------------------------------- -------SALSSLNVLRP-----------GEIPDAAFIHAARKKRQMARELGDFTP-VDS E-PGKGRLVR-ED--ENDA-SD-DEDDDEKRRIVFTVKEKSQRQKIAEE--I---GIEGS DDEALV-AGEQDEELSRWEQEQIRKGINIPQVQPSQPAEVNNVYYQNTYQTLSYGSSYGI PYTY--AAY-----------------------------GSS-DTKSQKADNTVPFKTPSN EMTPVTIDLVKKQLKD-R------------------------------------------ ----------------------LDSMKEMHKANRQQYEKHQQSQEDSTKAIERLEGSSGG IGERYKFLQEMRGYVQDLLECFSEKVPLINELESAMHQLYKQRASRLVQRRQDDIKDESS EFSSHS-------------------NKALMAPNLDSFGRDRVIYQEQVK-RRTAERE--- ---ARR-ARR-RQAREQTGKMADHLEGLSSDDEETSTDITNFNLERVLDRILKESSKVFE DVLESFYSIDCIKSQFEAWRSKYFASYKDAYIGLCLPKLFNPLIRLQLLTWTPLE----- -------------------------------GKCRDFETMLWFESLLFYGCEEQE--QVK DDADISLLPTIVERVVLPKLTVISENIWDPFSTT--------------QTSRMVAIVQKL IDGYPSVVNAENKN-----TQMLLKALLLRMRRTLDDDVFMPLYPKNILENKNSGPYLFF QRQFWSSVKLLGNFLQWYGILSNKTLQELSIDGLLNRYILMAFQNSEYGEDSIKKAQSVI ACFPKQWFTNLTGDKTISQLENFCRYLVHLADTIYRNSIGCSDVEKRNAREHIKQIIKLL ASIRALDHAVTVANDH----------------N------------VKEFKILIEGK-- >ENSCPGP00000022834 MVGRPLAVGGRAAAASERA----------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ GGGRGRCSGRRGGDHAQGAGPGPRRGLAGAGGAGAGTGAARRGGSLSSVPVGGMF----- ------------------------------------------------------------ --------------------RKARRVNVRKRNDSEEED-------EER------------ -------------------------------------------------------DEE-- ----------------------------------------PP----QEPAAPAAGGEGPG EASMALAA---------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------GSGLLPLPAGCVPLALPGSPAAFACAASYGAALGLGLGL VGGDRAGL---------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------GALPAPALL---PP ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------P-------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------PAP--- ----QQQQ---------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------------GNGLPAAGR P-------------------------KE-----------------------------KKR PRENKE--VP-------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------RAS----------------- ------------------LLSF-QDE-EE-ET---------------------------- ---------------------------------------------------------E-- ------EVFKVKKSSYSKKIVKQLKKEYKE------------------------------ ----------------------DLEKSK-------------------------------- ------------------------------------------------------------ ---------------------VRTEVN-----------S--------------------- -------------------PTDVEPPLEKTGQIKDIGQEDGTANSEHGEEEMEVES---- EKEEE------------------------------------------------------K PKA-GGAFS--------------------------------------------------- -------SALSSLNVLRP-----------GEIPDAAFIHAARKKRQMARELGDFTP-VDS E-PGKGRLVR-ED--ENDA-SD-DEDDDEKRRIVFAVKEKSQRQKIAEE--I---GIEGS DDEALV-AGEQDEELSRWEQEQIRKGINIPQVQPSQPAEVNNLYYQNTYQTLSYGSSYGI PYTY--ATY-----------------------------GSS-ETKSQKTDNTVPFKTPSN EMTPVTIDLVKKQLKD-R------------------------------------------ ----------------------LDSMKELHKANRQQYEKHQQSREDSTKAIERLEGSSGG IGEQYKFLQEMRGYVQDLLECFSEKVPLINELESAMHQLYKQRASRLVQRRQDDIKDESS EFSSHS-------------------NKALMAPNLESFGRDRVIYQEQVK-RRTAERE--- ---ARR-TRR-RQAREQTGKMADHLEGLSSDDEETSTDITNFNMER--DRILKESSKVFE DVLESFYSIDCIKSQFEAWRSKYFASYKDAYIGLCLPKLFNPLIRLQLLIWTPLE----- -------------------------------GKCRDFETMLWFESLLFYGCEEQE--QVK DDADISLLPTIVERVVLPKLTVISENIWDPFSTT--------------QTSRMVAIVQKL VDGYPSVVNAENKN-----TQMLLKALLLRMRRTLDDDVFMPLYPKNILENKNSGPYLFF QRQFWSSVKLLGNFLQWYGILSNKTLQELSIDGLLNRYILMAFQNSEYGEDSIKKAQSVI ACFPKQWFTNLKGDKTISQLENFCRYLVHLADTIYRNSIGCSDVEKRNAREHIKQIIKLL ASIRALDHAVTVANDH----------------NLKTSSKMKVKKS------------- >ENSNMEP00000011923 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------MF----- ------------------------------------------------------------ --------------------RKARRVNVRKRNDSEEED-------EER------------ -------------------------------------------------------DEE-- ----------------------------------------PP----QEPA---------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------PASGVGGEGPGEASAV ALAAA----------------GTGLLPLPPGCVPLALPGSPAAFACAAGYGAALGLGLGL IGGDRAGL---------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------GALPAPS-L---PP ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------P-------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------PQP--- ----QPPQ---------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------------GNGLPAAGR P-------------------------KE-----------------------------KKR PRENKE--VP-------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------RAS----------------- ------------------LLSF-QDE-EE-ET---------------------------- ---------------------------------------------------------E-- ------EVFKVKKSSYSKKIVKQLKKEYKE------------------------------ ----------------------DLEKSK-------------------------------- ------------------------------------------------------------ ---------------------VRTEVN-----------S--------------------- -------------------PTDVEPPLEKTGQIKDIGQEDGTANSEHGEEEMEVES---- EKEEE------------------------------------------------------K PKP-GGAFS--------------------------------------------------- -------SALSSLNVLRP-----------GEIPDAAFIHAARKKRQMARELGDFTP-VDS E-PGKSRLVR-ED--ENDA-SD-DEDDDEKRRIVFTVKEKSQRQKIAEE--I---GIEGS DDEALV-AGEQDEELSRWEQEQIRKGINIPQVQPSQPAEVNNLYYQNTYQTLSYGSSYGI PYTY--AAY-----------------------------GSS-ETKSQKTDNTVPFKTPSN EMTPITIDLVKKQLKD-R------------------------------------------ ----------------------LDSMKELHKANRQQFEKHQQSREDSTKAIERLEGSSGG IGEQYKFLQEMRGYVQDLLECFSEKVPLINELESAMHQLYKQRASRLVQRRQDDIKDESS EFSSHS-------------------NKALMAPNLDSFGRDRVLYQEQVK-RRTAERE--- ---ARR-ARR-RQAREQTGKMADHLEGLSSDDEETSTDITNFNMER--DRILKESSKVFE DVLESFYSIDCIKSQFEAWRSKYFASYKDAYIGLCLPKLFNPLIRLQLLIWTPLE----- -------------------------------GKCRDFETMLWFESLLFYGCEEQE--QEK DDADISLLPTIVERVVLPKLTVISENIWDPFSTT--------------QTSRMVAIVQKL VNGYPSVVNAENKN-----TQMLLKALLLRMRRTLDDDVFMPLYPKNILENKNSGPYLFF QRQFWSSVKLLGNFLQWYGILSNKTLQELSIDGLLNRYILMAFQNSEYGDDSIKKAQSVI ACFPKQWFANLKGDKTISQLENFCRYLVHLADTIYRNSIGCSDVEKRNAREQIKQIIKLL ASIRALDHAVTVANDH----------------N------------VKELKILIEGK-- >ENSAPLP00000011437 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------MF----- ------------------------------------------------------------ --------------------RKARRVNVRKRNASEEED-------EER------------ -------------------------------------------------------DEE-- ----------------------------------------PP----HDP----------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------PP--------------------- ---PAGEGPAEASTVAAAAV---GGGGGGPG----------------------------- ------------------------------------------------------------ ---------------------GPGLLPLPPGCVPLALPGSPAAFACAAGYGAALGLGLGL MAADRAGL---------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------GGPPPPSPLPPPPP ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------P-------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------PPA--- ----APQQ---------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------------GNGLPAAGR H-------------------------KE-----------------------------KKR PREGKE--VP-------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------RAS----------------- ------------------LLSF-QDE-EE-ET---------------------------- ---------------------------------------------------------E-- ------EVFKVKKSSYSKKIVKQLKKEYKE------------------------------ ----------------------DLEKSK-------------------------------- ------------------------------------------------------------ ---------------------VRTEVN-----------S--------------------- -------------------PTDVEPPLEKTGQIKDIGQEDGTANSEQGEEEMEVES---- EKEEE------------------------------------------------------K PKA-GGAFS--------------------------------------------------- -------SALSSLNVLRP-----------GEIPDAAFIHAARKKRQMARELGDFTP-VDS E-PGKGRLVR-ED--ENDA-SD-DEDDDEKRRIVFTVKEKSQRQKIAEE--I---GIEGS DDEALV-AGEQDEELSRWEQEQIRKGINIPQVQPSQPAEVNNLYYQNTYQTLSYGSSYGI PYTY--ATY-----------------------------GSS-ETKSQKTDNTVPFKTPSN EMTPITIDLVKKQLKD-R------------------------------------------ ----------------------LDSMKELHKANRQQYEKHQQSREDSTKAIERLEGSSGG IGEQYKFLQEMRGYVQDLLECFSEKVPLINELESAMHQLYKQRASRLVQRRQDDIKDESS EFSSHS-------------------NKALMAPNLDSFGRDRVLYQEQVK-RRTAERE--- ---ARR-ARR-RQAREQTGKMADHLEGLSSDDEETSTDITNFNMER--DRILKESSKVFE DVLESFYSIDCIKSQFEAWRSKYFASYKDAYIGLCLPKLFNPLIRLQLLIWTPLE----- -------------------------------GKCRDFETMLWFESLLFYGCEEQE--QEK DDADISLLPTIVERVVLPKLTVISENIWDPFSTT--------------QTSRMVAIVQKL VDGYPSVVNAENKN-----TQMLLKALLLRMRRTLDDDVFMPLYPKNILENKNSGPYLFF QRQFWSSVKLLGNFLQWYGILSNKTLQELSIDGLLNRYILMAFQNSEYGDDSIKKAQSVI ACFPKQWFANLKGDKTISQLENFCRYLVHLADTIYRNSIGCSDVEKRNAREQIKQIIKLL ASIRALDHAMTVANDH----------------N------------VKELKILIEGK-- >ENSABRP00000017967 MLGEP------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ----------------------GLGRGAVAGRRGAGGSAP-------------------- ------------------------------------------------------------ ---------------------------------------------------GGMF----- ------------------------------------------------------------ --------------------RKARRVNVRKRNDSEEED-------EER------------ -------------------------------------------------------DEE-- ----------------------------------------PP----HEP----------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------PPG-------------------- ---PAGEGPAEASAVAAAAAGGGGGGGGGPG----------------------------- ------------------------------------------------------------ ---------------------GPGLLPLPPGCVPLALPGSPAAFACAAGYGAALGLGLGL MAADRAGL---------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------GVPPPPSPL---PP ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------P-------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------PPA--- ----APQQ---------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------------GNGLPAAGR H-------------------------KE-----------------------------KKR PRESKE--VP-------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------RAS----------------- ------------------LLSF-QDE-EE-ET---------------------------- ---------------------------------------------------------E-- ------EVFKVKKSSYSKKIVKQLKKEYKE------------------------------ ----------------------DLEKSK-------------------------------- ------------------------------------------------------------ ---------------------VRTEVN-----------S--------------------- -------------------PTDVEPPLEKTGQIKDIGQEDGTANSEQGEEEMEVES---- EKEEE------------------------------------------------------K PKA-GGAFS--------------------------------------------------- -------SALSSLNVLRP-----------GEIPDAAFIHAARKKRQMARELGDFTP-VDS E-PGKGRLVR-ED--ENDA-SD-DEDDDEKRRIVFTVKEKSQRQKIAEE--I---GIEGS DDEALV-AGEQDEELSRWEQEQIRKGINIPQVQPSQPAEVNNLYYQNTYQTLSYGSSYGI PYTY--ATY-----------------------------GSS-ETKSQKTDNTVPFKTPSN EMTPITIDLVKKQLKD-R------------------------------------------ ----------------------LDSMKELHKANRQQYEKHQQSREDSTKAIERLEGSSGG IGEQYKFLQEMRGYVQDLLECFSEKVPLINELESAMHQLYKQRASRLVQRRQDDIKDESS EFSSHS-------------------NKALMAPNLDSFGRDRVLYQEQVK-RRTAERE--- ---ARR-ARR-RQAREQTGKMADHLEGLSSDDEETSTDITNFNMER--DRILKESSKVFE DVLESFYSIDCIKSQFEAWRSKYFASYKDAYIGLCLPKLFNPLIRLQLLIWTPLEVLVGL GYPYTLICLVMPWLVVSRQRGRKFSSLLGNQGKCRDFETMLWFESLLFYGCEEQE--QEK DDADISLLPTIVERVVLPKLTVISENIWDPFSTT--------------QTSRMVAIVQKL VDGYPSVVNAENKN-----TQMLLKALLLRMRRTLDDDVFMPLYPKNILENKNSGPYLFF QRQFWSSVKLLGNFLQWYGILSNKTLQELSIDGLLNRYILMAFQNSEYGDDSIKKAQSVI ACFPKQWFANLKGDKTISQLENFCRYLVHLADTIYRNSIGCSDVEKRNAREQIKQIIKLL ASIRALDHAMTVANDH----------------N------------VKELKILIEGK-- >ENSMUNP00000007643 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------M------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------RSATRSRLRSRRRRPRGVRGRGRRGLHGAGGGPRAPAATRRLRAPRLARQ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------PAAFACAASYGAALGLGLSL SGGDRTSL---------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------GALPAAAFL---PP ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------P-------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------PPP--- ----QQQQ---------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------------GNGLPGPGR P-------------------------KE-----------------------------KKR TRENKE--VP-------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------RAS----------------- ------------------LLSF-QDE-EE-ET---------------------------- ---------------------------------------------------------E-- ------EVFKVKKSSYSKKIVKQLKKEYKE------------------------------ ----------------------DLEKSK-------------------------------- ------------------------------------------------------------ ---------------------VRTEVN-----------S--------------------- -------------------PTDVEPPLEKTGQIKDIGQEDGTANSEHGEEEMEVES---- EKEEE------------------------------------------------------K PKA-GGAFS--------------------------------------------------- -------SALSSLNVLRP-----------GEIPDAAFIHAARKKRQMARELGDFTP-VDS E-PGKGRLVR-ED--ENDA-SD-DEDDDEKRRIVFTVKEKSQRQKIAEE--I---GIEGS DDEALV-AGEQDEELSRWEQEQIRKGINIPQVQPTQPAEVNNLYYQNTYQTLSYGSSYGV PYTY--TAY-----------------------------GSS-ETKSQKTDNTVPFKTPSN EMTPVTIDLVKKQLKD-R------------------------------------------ ----------------------LDSMKELHNANRQQYEKHQQSREDSTKAIERLEGSSGG IGEQYKFLQEMRGYVQDLLECFSEKVPLINELESAMHQLYKQRASRLVQRRQDDIKDESS EFSSHS-------------------NKALMAPNLESFGRDRVIYQEQVK-RRTAERE--- ---ARR-ARR-RQAREQTGKMADHLEGLSSDDEETSTDITNFNMER--DRILKESSKVFE DVLESFYSIDCIKSQFEAWRSKYFASYKDAYIGLCLPKLFNPLIRLQLLIWTPLE----- -------------------------------GKCRDFETMLWFESLLFYGCEEQE--QVK DDADISLLPTIVERVVLPKLTVISENIWDPFSTT--------------QTSRMVAIVQKL VDGYPSVVNAENKN-----TQMLLKALLLRMRRTLDDDVFMPLYPKNILENKNSGPYLFF QRQFWSSVKLLGNFLQWYGILSNKTLQELSIDGLLNRYILMAFQNSEYGEDSIKKAQSVI ACFPKQWFTNLKGDKTISQLENFCRYLVHLADTIYRNSIGCSDVEKRNAREHIKQIIKLL ASIRALDHAVTVANDH----------------N------------IKELKILIEGK-- >ENSAOWP00000013056 M----------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------AAAADGKGACRAARRAALAAPLYAPRRARSARRPXXXXXXXXXXXXX XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX XXXXXXXXXXXXXXXXXXXXXXXXXXXXXGALP--------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------------PP ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------ALLP-------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------PPPQ-- --QQQQQQ---------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------------GNGLPGAGR A-------------------------KE-----------------------------KKR AREHRE--AP-------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------RAS----------------- ------------------LLSF-QDE-EE-ET---------------------------- ---------------------------------------------------------E-- ------EVFKVKKSSYSKKIVKQLKKEYKE------------------------------ ----------------------DLEKSK-------------------------------- ------------------------------------------------------------ ---------------------VRTEVN-----------S--------------------- -------------------PTDVEPPLEKTGLTKDISQEDGTANSEQGEEEMEVES---- EKEEE------------------------------------------------------K PKA-GGAFS--------------------------------------------------- -------SALSSLNVLRP-----------GEIPDAAFIHAARKKRQMARELGDFTP-VDS E-PGKSRLVR-ED--ENDA-SD-DEDDDEKRRIVFTVKEKSQRQKIAEE--I---GIEGS DDEALV-TGEQDEELSRWEQEQIRKGINIPQVQPSQPAEVNNLYYQNTYQTLSYGSSYGI PYTY--AAY-----------------------------GSS-ETKSQKTDNTVPFKTPSN EMTPVTIDLVKKQLKD-R------------------------------------------ ----------------------LDSMKELHKANRQQYEKHQQSREDSTKAIERLEGSSGG IGEQYKFLQEMRGYVQDLLECFSEKVPLINELESAMHQLYKQRASRLVQRRQDDIKDESS EFSSHS-------------------NKALMAPNLDSFGRDRALYQEQVK-RRTAERE--- ---ARR-ARR-RQAREQTGKMADHLEGLSSDDEETSTDITNFNMER--DRILKESSKVFE DVLESFYSIDCIKSQFEAWRSKYYASYKDAYIGLCLPKLFNPLIRLQLLIWTPLE----- -------------------------------GKCRDFETMLWFESLLFYGCEEQE--QEK DDADISLLPTIVERVVLPKLTVISENIWDPFSTT--------------QTSRMVAIVQKL VDGYPSVVNAENKN-----TQMLLKALLLRMRRTLDDDVFMPLYPKNILENKNSGPYLFF QRQFWSSVKLLGNFLQWCGILSNKTLQELSIDGLLNRYILMAFQNSEYGDDSIKKAQSVI ACFPKQWFTNLKGDKTISQLENFCRYLVHLADTIYRNSIGCSDVEKRNARENIKQIIKLL ASIRALDHAVTVANDH----------------N------------VKELKILIEGK-- >ENSARWP00000020053 M----------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------AAAAEGKGACRAARRAALAAPLYAPRRARSARR-------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------------P AA---------------------------------------------------------- ------------------ALWSAGG----------------------------------- ----------SA------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------QRAGRGGXXXXXXX XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX XXXXXXXXXXXXALLP-------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------PPPQ-- --QQQQQQQQGNPPPPPPLHPPGAAAAAAATA---------------------------- --ATA--------------------------AGQRAAGGRARQGEEAGAGAQRGAAGQPA QLPGRG---------GG------------------------------------------- SNVIS----------------------------------------FNFSFK--------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------ET---------------------------- ---------------------------------------------------------E-- ------EVFKVKKSSYSKKIVKQLKKEYKE------------------------------ ----------------------DLEKSK-------------------------------- ------------------------------------------------------------ ---------------------VRTEVN-----------S--------------------- -------------------PTDVEPSLEKTGLTKDISQEDGTANSEQGEEEMEVES---- EKEEE------------------------------------------------------K PKA-GGAFS--------------------------------------------------- -------SALSSLNVLRP-----------GEIPDAAFIHAARKKRQMARELGDFTP-VDS E-PGKSRLVR-ED--ENDA-SD-DEDDDEKRRIVFTVKEKSQRQKIAEE--I---GIEGS DDEALV-TGEQDEELSRWEQEQIRKGINIPQVQPSQPAEVNNLYYQNTYQTLSYGSSYGI PYTY--AAY-----------------------------GSS-ETKSQKTDNTVPFKTPSN EMTPVTIDLVKKQLKD-R------------------------------------------ ----------------------LDSMKELHKANRQQYEKHQQSREDSTKAIERLEGSSGG IGEQYKFLQEMRGYVQDLLECFSEKVPLINELESAMHQLYKQRASRLVQRRQDDIKDESS EFSSHS-------------------NKALMAPNLDSFGRDRALYQEQVK-RRTAERE--- ---ARR-ARR-RQAREQTGKMADHLEGLSSDDEETSTDITNFNMER--DRILKESSRVFE DVLESFYSIDCIKSQFEAWRSKYYASYKDAYIGLCLPKLFNPLIRLQLLIWTPLE----- -------------------------------GKCRDFETMLWFESLLFYGCEEQE--QEK DDADISLLPTIVERVVLPKLTVISENIWDPFSTT--------------QTSRMVAIVQKL VDGYPSVVNAENKN-----TQMLLKALLLRMRRTLDDDVFMPLYPKNILENKNSGPYLFF QRQFWSSVKLLGNFLQWCGILSNKTLQELSIDGLLNRYILMAFQNSEYGDDSIKKAQSVI ACFPKQWFTNLKGDKTISQLENFCRYLVHLADTIYRNSIGCSDVEKRNARENIKQIIKLL ASIRALDHAVTVANDH----------------N------------VKELKILIEGK-- >ENSDNVP00000021478 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------CLTKDGGSGRREGGVAGRSGRGSLCS ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------------PP ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----GTLYPLPRRRSMVGGRPGAAGGPRRTAGGRGILLCRSNVMFFNFSLK--------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------ET---------------------------- ---------------------------------------------------------E-- ------EVFKVKKSSYSKKIVKQLKKEYKE------------------------------ ----------------------DLEKSK-------------------------------- ------------------------------------------------------------ ---------------------VRTEVN-----------S--------------------- -------------------PTDVEPPLEKDIRIKDISQEDGTTNSEQGEEEMEVES---- EKEEE------------------------------------------------------K PKA-GGAFS--------------------------------------------------- -------SALSSLNVLRP-----------GEIPDAAFIHAARKKRQMARELGDFTP-VDS E-PGKSRLVR-ED--ENDA-SD-DEDDDEKRRIVFTVKEKSQRQKIAEE--I---GIEGS DDEALV-TGEQDEELSRWEQEQIRKGINIPQVQPSQPAEVNNLYYQNTYQTLSYGSSYGI PYTY--AAY-----------------------------GSS-ETKSQKTDNTVPFKTPSN EMTPVTIDLVKKQLKD-R------------------------------------------ ----------------------LDSMKELHKANRQQYEKHQQSREDSTKAIERLEGSSGG IGEQYKFLQEMRGYVQDLLECFSEKVPLINELESAMHQLYKQRASRLVQRRQDDIKDESS EFSSHS-------------------NKALMAPNLDSFGRDRALYQEQVK-RRTAERE--- ---ARR-ARR-RQAREQTGKMADHLEGLSSDDEETSTDITNFNMER--DRILKESSKVFE DVLESFYSIDCIKSQFEAWRSKYFASYKDAYIGLCLPKLFNPLIRLQLLIWTPLE----- -------------------------------GKCRDFETMLWFESLLFYGCEEQE--QEK DDADILLLPTIVERVVLPKLTVISENIWDPFSTT--------------QTSRMVAIVQKL VDGYPSVVNAENKN-----TQMLLKALLLRMRRTLDDDVFMPLYPKNILENKNSGPYLFF QRQFWSSVKLLGNFLQWCGILSNKTLQELSIDGLLNRYILMAFQNSEYGDDSIKKAQSVI ACFPKQWFTNLKGDKTISQLENFCRYLVHLADTIYRNSIGCSDVEKRNARENIKQIIKLL ASIRALDHAVTVANDH----------------N------------VKELKILIEGK-- >ENSAHAP00000027088 M----------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --LXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX XXXXXXXXXAAGQRAAGGRARQGEEAAAAARRAGPGPQLIVLFPSGVCYA---------- ----------------------------------------------------------PP ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------GPSPAGSCFGGDTALPVRAGGAWPRWACATLGPASAPLRNLPLQ SNVIS----------------------------------------FNFSFK--------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------ET---------------------------- ---------------------------------------------------------E-- ------EVFKVKKSSYSKKIVKQLKKEYKE------------------------------ ----------------------DLEKSK-------------------------------- ------------------------------------------------------------ ---------------------VRTEVN-----------S--------------------- -------------------PTDVEPPLEKTGLTKDISQEDGTANSEQGEEEMEVES---- EKEEE------------------------------------------------------K PKA-GGAFS--------------------------------------------------- -------SALSSLNVLRP-----------GEIPDAAFIHAARKKRQMARELGDFTP-VDS E-PGKSRLVR-ED--ENDA-SD-DEDDDEKRRIVFTVKEKSQRQKIAEE--I---GIEGS DDEALV-TGEQDEELSRWEQEQIRKGINIPQVQPSQPAEVNNLYYQNTYQTLSYGSSYGI PYTY--AAY-----------------------------GSS-ETKSQKTDNTVPFKTPSN EMTPVTIDLVKKQLKD-R------------------------------------------ ----------------------LDSMKELHKANRQQYEKHQQSREDSTKAIERLEGSSGG IGEQYKFLQEMRGYVQDLLECFSEKVPLINELESAMHQLYKQRASRLVQRRQDDIKDESS EFSSHS-------------------NKALMAPNLDSFGRDRALYQEQVK-RRTAERE--- ---ARR-ARR-RQAREQTGKMADHLEGLSSDDEETSTDITNFNMER--DRILKESSKVFE DVLESFYSIDCIKSQFEAWRSKYYASYKDAYIGLCLPKLFNPLIRLQLLIWTPLE----- -------------------------------GKCRDFETMLWFESLLFYGCEEQE--QEK DDADISLLPTIVERVVLPKLTVISENIWDPFSTT--------------QTSRMVAIVQKL VDGYPSVVNAENKN-----TQMLLKALLLRMRRTLDDDVFMPLYPKNILENKNSGPYLFF QRQFWSSVKLLGNFLQWCGILSNKTLQELSIDGLLNRYILMAFQNSEYGDDSIKKAQSVI ACFPKQWFTNLKGDKTISQLENFCRYLVHLADTIYRNSIGCSDVEKRNARENIKQIIKLL ASIRALDHAVTVANDH----------------N------------VKELKILIEGK-- >ENSCPRP00005020794 M----------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------AARDSSPQPQADPSLLFL YGAARRSSPPRSAFWPGACAGGGRPXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX- ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------RKRNESEEED-------EER------------ -------------------------------------------------------DEE-- ----------------------------------------P------------------- ------------------------------------------------------------ ------------------------------------HEPVMAVADGPGGSPTAPTPVPSL GPG--------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------PAAA------------------------ ------------------------------------------------------------ --------------------------------------------P--------------- ------------------------LLPLPPGCLPLA------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------PTGFNCAAGGFSLSLGLAAGPGPLA--------------PP A----------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------LP-------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------PPPAPA QPPQQQQQ---------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------------GNGLPGAAR A-------------------------KE-----------------------------KRR GRENKE--TA-------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------RGS----------------- ------------------LLSF-RDE-EE-EA---------------------------- ---------------------------------------------------------E-- ------EVFKVKKSSYSKKIVKQLKKEYKE------------------------------ ----------------------DLEKSK-------------------------------- ------------------------------------------------------------ ---------------------VKTEVS-----------S--------------------- -------------------PSDAEPPIEKTGQIKDASQEDGTTNSEQGEEEMEVES---- EKEEE------------------------------------------------------K PKA-GGAFS--------------------------------------------------- -------SALSSLNVLRP-----------GEIPDAAFIHAARKKRQMARELGDFTP-VDN E-PGKGRLVR-ED--ENDA-SD-DEDDDEKRRIVFSVKEKSQRQKIAEE--I---GIEGS DDEALV-TGEQDEELSRWEQEQIRKGINIPQVQASQPTEVNNLYYQNTYQTLSYGSSYGI PYTY--AAY-----------------------------GSS-ETKSQKTDNTVPFKTPSN EMTPVTIDLVKKQLKD-R------------------------------------------ ----------------------LDSMKDLHRANRQQYEKHQQSREDSAKAIERLEGSSGG IGERYKFLQEMRGYVQDLLECFSEKVPLINELESSMHQLYKQRASRLVQRRQDDIKDESS EFSSHS-------------------SKALMAPNLDSFGRDRALYQEQVK-RRTAERE--- ---ARR-ARR-RQAREQTGKIADHLEGLSSDDEETSTDITNFNLER--DRILKESSKVFE DVLESFYSIDCIKSQFEAWRSKYSSSYKDAYIGLCLPKLFNPLIRLQLLTWNPLE----- -------------------------------GKCRDFENMLWFESLLFYGCEEQE--QEK DDADISLLPTIVERVVLPKLTVIAENIWDPFSTS--------------QTSKMVAITQKL VDGYPSVVNAENKN-----TQTFLKALLLRMRRTLDDDVFMPLYPKNVLENKNSGPYLFF QRQFWSSVKLLGNFLQWYGILSNKALQELSIDGLLNRYILMAFQNSEYGDDSIKKAQSVI ACFPKQWFTNLKGDKTIIQLENFCRYLVHLADVIYRNSIGCSDVEKRNAREHIKQIIKLL ASVRALDHAVTVANDH----------------N------------VKELKVLIEGK-- >ENSSMRP00000030034 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------MF----- ------------------------------------------------------------ --------------------RKARRVNVRKRNESEDDD-------EER------------ -------------------------------------------------------DED-- ----------------------------------------PP------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------PPQQPSQLLPAGGDGPGGEADLP AAKP-------------------------------------------------------- --------------------------------------------P--------------- ------------------------LLPLPTGCVPLV------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------------PP ------------------------------------------------------------ -----------------------GGGSGSGGSFAFGGAAGETVGRGGPGLTAPQPPVALL PTPPQQPPQHP------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------P-------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------PPP--- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------ASGNNGLVVAPASKLKERK NKNKEAAGAAAVPRGSLKLLSF-QDE-EE-ET---------------------------- ---------------------------------------------------------E-- ------EVFKVKKSSYSKKIVKLLKKEYKE------------------------------ ----------------------DLEKSK-------------------------------- ------------------------------------------------------------ ---------------------LKPETN-----------S--------------------- -------------------SADAEQCTEKTGQIKDAVQEDGAANSEQGEEEMEVES---- EKEED------------------------------------------------------K PKA-ASAFS--------------------------------------------------- -------SALSSLNVLRP-----------GEIPDAAFIHAARKKRQMARELGDFLP-LDS D-PGKGRLIR-ED--ENDA-SD-DEDDDEKRRIVFSVKEKSQRQKIAEE--I---GIEGS DDEALI-AGEQDEELSRWEQEQIRKGINIPQVQATQPAEVNNLYYQSTYQTISYGSSYGI PYTY--AAY-----------------------------GSS-ETKSQKTDNTIPFKTPNN EMTPVTIDLVKKQLKD-R------------------------------------------ ----------------------LDSMKEFHKANQQQHEKHQQSRDDSTKTIERLEGSSGG VGERYKFLQEMRGYVQDLLECFSEKVILINELESAMHQLYKQRASRLVQRRQDDIKDESS EFSSHS-------------------SKALMAPNLDSFGRDRTLYQEHVK-RRTAERE--- ---ARR-ARR-RLAREQSGKMADHLEGLSSDDEETSTDTTNFNMER--DRIMKESSKVFE DVLENFASIDCIKSQFETWRSKYFSSYKDAYIGLCLPRLLNPLIRLQLLTWNPLE----- -------------------------------DKCQDFESMLWFESLLFYGCEEYD--QEK DDADVSLLPTIVERVLLPKLTVLAESVWDPFSTT--------------QTSRMVAIIQKL INGYPSVVHAENKN-----TQILLKALLLRMRRTLDDDVFMPLYPKSVLENKNSGPYLFF QRQFWSSVKLLGNFLQWYGILSNKTLQELAIDGLLNRYILMAFQNSEYGDDSIKKAQSVI SCFPKQWFXNLKGNKTISHLENLCRYLVHLADTMYRNSIGSSDVEKRNTRENIKQIIKLL SSIRALDHAVAVANDH----------------N------------VKEMKVLSEGK-- >ENSPVIP00000010738 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------E-ES---------------------------- ---------------------------------------------------------E-- ------EVFKVKKSSYSKKIVKLLKKEYKE------------------------------ ----------------------DLEKSKTK----------------SETVSSLDAEQSAD KTGQIK------------------------------------------------------ ------------------DTTL-------------------------------------- --------------------------------------EDGATNSEQGEDEMEVES---- EKEEE------------------------------------------------------K PKA-AGAFS--------------------------------------------------- -------SALSSLNVLRP-----------GEIPDAAFIHAARKKRQMARELGDFLP-LDS D-TGKGRLVR-ED--ENDA-SD-DEDDDEKRRIVFSVKEKSQRQKIAEE--I---GIEGS DDEALI-AGEQDEELSRWEQEQIRKGINIPQVQATQPAEVNNLYYQNTYQTMPYGSSYGI PYTY--AAY-----------------------------GAS-ETKSQKTDNTVPFKTPSN EMTPVTIDLVKKQLKD-R------------------------------------------ ----------------------LDTMKEFHKANQQQYEKHQQSRDDSTKAIERLEGSSGG VAERYKFLQEMRGYVQDLLECFSEKVLLINELESAMHQLYKQRASRLVQRRQDDIKDESS EFSSHS-------------------NKALMAPNLDSFGRDRALYQEHVK-RRTAERE--- ---ARRYTRR-RLAREQSGKMADHLEGLSSDDEETSTDTTNFNMER--DRILKESSKVFE DVLENFSSIDCIKTQFEAWRSKYLSSYKDAYIGLCLPKLLNPLIRLQLLTWNPLE----- -------------------------------EKCQDFESMLWFESLLFYGCEEYD--QEK DDADVSLLPTIVERVLLPKLTVLAENVWDPFSTT--------------QTSRMVAITQKL ISGYPSVVHAENKN-----TQTLLKALLLRMRRTLDDDVFMPLYPKSVLENKNSGPYLFF QRQFWSSVKLLGNFLQWYGILSNKTLQELAIDGLLNRYILMAFQNSEYGDDSIKKAQSVI SSFPKQWFTNLKGNKTISHLENLCRYLVHLADTLYRNSIGSSDVEKRNAREHIKQIIKLL SSIRALDHAVTVANDH----------------N------------VKELKILSEGK-- >ENSACAP00000003129 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------MF----- ------------------------------------------------------------ --------------------RKARRVNVRKRNESEE------------------------ -------------------------------------------------------EEDDE KDEAPPPQAQAS-----SQAGGAGPEAEAELTPFP----PPP------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------PP------------------SLP APKP-------------------------------------------------------- --------------------------------------------P--------------- ------------------------LLPLPTGCLPLV------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------------PP ------------------------------------------------------------ -----------------------G------------------------------------ -----RPPAPP------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------P-------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------PP---- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------RGSLKLLSF-QDE-EE-ET---------------------------- ---------------------------------------------------------E-- ------EVFKVKKSSYSKKIVKLLKKEYKE------------------------------ ----------------------DLEKCK-------------------------------- ------------------------------------------------------------ ---------------------TRPETN-----------S--------------------- -------------------SVDVEQSADK-GQAKDAVQEDGVAISEQGEEEMEVES---- EKEEE------------------------------------------------------K SKA-AGAFS--------------------------------------------------- -------SALSSLNVLRP-----------GEIPDAAFIHAARKKRQMARELGDFLP-LDN D-PGKGRLIR-ED--DNDA-SD-DEDDDEKRRIVFSVKEKSQRQKIAEE--I---GIEGS DDDALI-AGEQDEELSRWEQEQIRKGINIPQVQASQPADMNNLYYQNIYQAMPYGSSYGI PYTY--AAY-----------------------------GSS-ETKAPKTDNTIPFKTSNN EMTPVTIDLVKKQLKD-R------------------------------------------ ----------------------LDSMKERHRSNQQQLENHQQSRDDSIKTIERLEGSSGG VGERYKFLQEMRGYVQDLLECFSEKVILINELESSMHQLYKQRASRLVQRRQDDIKDESS EFSSHS-------------------SKALMAPNLDSFGRDRTLYQEHVK-RRTAERE--- ---ARSRARR-RLAREQSGKMADHLEGLSSDDEETSTDTTNFNMER--DRILKESSKVFE DVLENFSSIDCIKSQFEAWRSKYLSTYKDAYIGLCLPKLLNPLIRLQLLTWNPLE----- -------------------------------GKCQDFESMLWFESLLFYGCEEND--QDK DDADVSLLPTIVERVLLPKLTVLAENVWDPFSTT--------------QTSRMVAITQKL VNGYPSVVHAENKN-----TQTLLKGLLLRMRRTLDDDVFMPLYPKSVLENKNSGPYLFF QRQFWSSVKLLGNFLQWYGILSNKTLQELAIDGLLNRYILMAFQNSEYGDDSIKKAQSVI SCFPKQWFTNLKGNKTISHLENLCRYLVHLADTIYRNSIGSSDVEKRNAREHIKQIIKLL SSIRALDHAVTVANEH----------------N------------VKELK--SEGK-- >ENSCPBP00000008146 M----------------------------------------------------------- ------------------------------------------------------------ -----------------VARGTLARRGTLWCGAQSFPLPPLGLAGRAGRWRCDCPVIMLR GGGAGAGPRRAAAGRVSGLRGAG----------------P-------------------- ------------------------------------------------------------ ---------------------------------------------------GGMF----- ------------------------------------------------------------ --------------------RKARRVNVRKRNDSEEED-------EER------------ -------------------------------------------------------ERDEE ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---PQ------------------------------------------------------- -----------------------ESLGADGPGEAAMAQ----AAP--------------- ------------------------LLPLPTGCVPLVVP---------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------AL-TGYG AGSGLGPGFGPGLAALLP----------------------------------------P- ------------------------------------------------------------ ------------------------------------------------------------ ----------P------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------P-------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------PPP--- ------QQ---------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------------GNGLPGAGR A-------------------------KE-----------------------------RKR LRENKEATAP-------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------RAS----------------- ------------------LLSF-QDE-EE-EA---------------------------- ---------------------------------------------------------E-- ------EVFKVKKSSYSKKIVKLLKKEYKE------------------------------ ----------------------DLEKSK-------------------------------- ------------------------------------------------------------ ---------------------VKPEVN-----------S--------------------- -------------------PADAEQAIEKIGQVKDANQEDGTANSEQGEEEMEVES---- EKEEE------------------------------------------------------K PKT-GGAFS--------------------------------------------------- -------SALSSLNVLRP-----------GEIPDAAFIHAARKKRQMARELGDFTP-IDN E-PGKGRLVR-ED--ENDA-SD-DEDDDEKRRIVFSVKEKSQRQKIAEE--I---GIEGS DDEALV-TGEQDEELSRWEQEQIRKGINIPQVQASQPTDVNNLYYHNSYQTMSYGSSYGI PYTY--AAY-----------------------------GSS-ETKSQKTDNILPFKTPSN EMTPVTIDLVKKQLTD-R------------------------------------------ ----------------------LDSMKELNKANQQQHEKHQQSREDSTKAIERLEGSSGG IGERYKFLQEMRGYVQDLLECFSEKVPLINELESAMHQLYKQRASRLVQRRQDDIKDESS EFSSHS-------------------SKALMAPNLDSFGRDRALYQEYVK-RRTAERE--- ---ARRYTRR-RQAREQTGKMADHFEGLSSDDEETSTDITNFNMER--DRILKESSKVFE DVLESFYSIDCIKSQFEAWRSKYFSSYKDAYIGLCLPKLFNPLIRLQLLTWTPLE----- -------------------------------GKCQDFESMLWFESLLFYGCEEQE--QEK DDADISLLPTIVERVVLPKLTVLAESIWDPFSTT--------------QTSRMVAVTQKL VNGYPSVVNAENKN-----TQTLLKALLLRMRRTLDDDVFMPLYPKNILENKNSGPYLFF QRQFWSSVKLLGNFLQWYGILSNKTLQELSIDGLLNRYILMAFQNSEYGDDSIKKAQSVI ACFPKQWFTNLKGDKTISQLENLCRYLVHLADTIYRNSIGCSDVEKRNAREHIKQTVKLL ASIRALDHAVTVANEH----------------N------------VKELKVLIEGK-- >ENSCABP00000011410 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------MF----- ------------------------------------------------------------ --------------------RKARRVNVRKRNDSEEED-------EER------------ -------------------------------------------------------ERDEE ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---P-------------------------------------------------------- -------------------------LGPDGPGEPAMAQ----AAP--------------- ------------------------LLPLPTGCVPLAVP---------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------SLTTGYG AGSGLGLGFGPGLAALL------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ----------P------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------P-------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------PSP--- ------QQ---------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------------GNGLPGAGR A-------------------------KE-----------------------------RKR LRENKEA-AP-------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------RAS----------------- ------------------LLSF-QDE-EE-EA---------------------------- ---------------------------------------------------------E-- ------EVFKVKKSSYSKKIVKLLKKEYKE------------------------------ ----------------------DLEKSK-------------------------------- ------------------------------------------------------------ ---------------------VKPEVN-----------S--------------------- -------------------PADAEQAIERTGQVKDANQEDGTANSEQGEEEMEVES---- EKEEE------------------------------------------------------K PKT-GGAFS--------------------------------------------------- -------SALSSLNVLRP-----------GEIPDAAFIHAARKKRQMARELGDFTP-IDN E-PGKGRLVR-ED--ENDA-SD-DEDDDEKRRIVFSVKEKSQRQKIAEE--I---GIEGS DDEALV-TGEQDEELSRWEQEQIRKGINIPQVQASQPTEVNNLYYHNSYQTMSYGSSYGI PYTY--AAY-----------------------------GSS-ETKSQKTDNTLPFKTPSN EMTPVTIDLVKKQLKD-R------------------------------------------ ----------------------LDSMKELNKANQQQHEKHQQSREDSTKAIERLEGSSGG IGERYKFLQEMRGYVQDLLECFSEKVPLINELESAMHQLYKQRASRLVQRRQDDIKDESS EFSSHS-------------------SKALMAPNLDSFGRDRALYQEHVK-RRTAERE--- ---ARR-ARR-RQAREQTGKMADHFEGLSSDDEETSTDITNFNMER--DRILKESSKVFE DVLESFYSIDCIKSQFEAWRSKYFSSYKDAYIGLCLPKLFNPLVRLQLLTWTPLE----- -------------------------------GKSQDFESMLWFESLLFYGCEEQE--QEK DDVDISLLPTIVERVVLPKLTVLAESIWDPFSTT--------------QTSRMVAVTQKL VNGYPSVVNAENKN-----TQTLLKALLLRMRRTLDDDVFMPLYPKNILENKNSGPYLFF QRQFWSSVKLLGNFLQWYGILSNKTLQELSIDGLLNRYILMAFQNSEYGDDSIKKAQSVI ACFPKQWFTNLKGDKTISQLENLCRYLVHLADTIYRNSIGCSDVEKRNAREHIKQTVKLL ASIRALDHAVTVANEH----------------N------------VKELKVLIEGK-- >ENSSPUP00000016250 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------MF----- ------------------------------------------------------------ --------------------RKARRVNVRKRNESEEED-------EER------------ -------------------------------------------------------DEE-- ---------------------------------LPLQVLPPP------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---P-------------------------------------------------------- ------LLGGDGPGVEVVPATP---------------------AP--------------- ------------------------LLPLPTDCVPLALPG--------------------- --------------------TFALGSAGIGPGGGTANLAAPQLLPPPLPPPPPPPPHPAP PPGNNGLPAAAKPKERKRLNKETAL----------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------------PP ------------------------------------------------------------ -----------------------------------------------------------L P-----PPAPP------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------P-------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------PP---- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------RGSTSLLSF-QDE-EE-EA---------------------------- ---------------------------------------------------------E-- ------EVFKVKKSSYSKKIVKLLKKEYKE------------------------------ ----------------------DLEKSK-------------------------------- ------------------------------------------------------------ ---------------------TKTEVN-----------S--------------------- -------------------AADADQPLDKTGQNKDAIQEDGAANSEQGEEEMEVES---- EKEEE------------------------------------------------------K PKA-GGAFS--------------------------------------------------- -------NTLSSLNVLRP-----------GEIPDAAFIHAARKKRQMARELGDFTP-IDS E-PGKGRLIR-ED--ENDA-SD-DEDDDEKRRIVFSVKEKSQRQKIAEE--I---GIEGS DDEALG-TGEQDEELSRWEQEQIRKGINIPQVQASHPTEVNNLYYQNTYQTLSYGSSYGI PYTY--AAY-----------------------------GPS-ETKSLKTDNTIPFKTPSN EMTPVTIDLVKKQLKD-R------------------------------------------ ----------------------LESMKELHKANRQQHEKHQQSREDSSKAIERLEGSSGG VGERYKFLQEMRGYVQDLLECFNEKVPLINELESAAHQLYKQRASRLVQRRQDDIKDESS EFSSHS-------------------SKALMAPNLDSFGRDRALYQEHVK-RRTAERE--- ---ARR-ARR-RQAREQTGKMADHLEGLSSDDEETSTDITNFNMEQ--DRILKESSKVFE DVLESFYSIDCIKSQFEAWRSKYFSSYKDAYIGLCLPKLFNPLIRLQLLTWNPLE----- -------------------------------GKCRDFESMLWFESLLFYGCEEQE--QEK DDADISLLPTIVERVVLPKLTVIAENIWDPFSTT--------------QTSRMVAITQKL VNGYPSVVNAENKN-----TQTFLKALLLRMRRTLDDDVFMPLYPKSVLENKNSGPYLFF QRQFWSSVKLLGNFLQWYGILSNKTLQELSIDGLLNRYILMAFQNSEYGDDSIKKAQSVI GCFPKHWFVNLKGDRTIPQLENFCRYLVHLADTVYRNSIGCSDVEKRNAREHIKQIIKLL ASVRALDHAVTVANDH----------------N------------VKELKILIEGK-- >ENSXETP00000005279 ---------------------------------------------------YKGSLHCLI IPSEWSLLIGASFLRCKIVSSTGQGPP--SS----CVSDSYCNSRCGVS----------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------------SGMF----- ------------------------------------------------------------ --------------------RKARRVNVRKRNDSEDEE-------REA------------ -------------------------------------------------------D---- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------ANS--------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------AAPAA------------- ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------E------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------------PS ------------------------------------------------------------ ----------------E------------------------------------------- ----------P------------------------------------VFSVFEHPVSI-- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------P-------------------------------------------- ------------------------------------------------------------ -----------------------------------LLGP----DTG--------PP---- ------------------------------------------------------------ ------------------------------------------------------------ ----RGKKEGNSVMSKG------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------N---------------------------- ---------------------------------------------------------E-- ------EIFKVKKSNHSKKIVKMLKKEYKD------------------------------ ----------------------DLEKTKPKASLPPKDGIQEDIAVGSDL----------- ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------GEEEMEVES---- EKEEE------------------------------------------------------K PKA--GSFT--------------------------------------------------- -------NAVSSLNVLRP-----------GEIPDAAFIHAARKKRQMARELGDAPS-VDG EGGGKSRLVR-ED--ENDA-SD-DEDDD-KRRIVFSVREKSQRQKIAEE--I---GIEGS DDEALA-TGDQDEELSRWEQEQIRKGISIPQVQAPQPPET-NMFYPSTYQGMPYGTSYGV PYTY--AAY-----------------------------GST-ETKSQKPDNSVSFKTPSN EMTPVTIDLVKKQLKD-R------------------------------------------ ----------------------LDAMKEVHKANLEQYEKHVQSREDSTSSISRLEGCSGS NAERYQFLQEMRGYVQDLLECFREKVPLINELESAMHQLYKQRAARLVQRRQDDIKDESS EFSSHS-------------------SKAVMAPNLDPFGRDRALFQEHAKQRRIAERE--- ---ARR-TRR-RQAREVPGKTAEHLEGLSSDDEETSTDITNFNMEK--DRILKEAGKVFE DTLENFHSIEYIKDQFESWRSTYYSTYKDAYIGLCLPKLLNPLVRIQLLTWNPLE----- -------------------------------ANCCNFESMMWFECLLFYGCEEKE--YDK EDVDIVLLPSLVEKVILPKLAGIAENVWDPFSTT--------------QTNRLAAVVQKL VNGYPTVLNSENKN-----TEALLKALLARMRRTLDDDVFMPLYPKNVIENKNSAPCIFF QRQFWSSVKLLGNFLKWHGVLSNKALQELSVDGLLNRYILMAFQNNENGEDSIKKAQSVI TCFPRQWFANLKGGKTIPQLENFARYLTHLAGTIYRNNVGCSDIERRNAREQIRQIVKLL ASIRALESAMSVANDY----------------N------------VKDIKAPTEGK-- >ENSLACP00000009286 -------------------AN--------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------P-------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------------GK I-------------------------KE-----------------------------KKK NKESKE--LP-------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------KAS----------------- ------------------LLSF-QDE-EE-ET---------------------------- ---------------------------------------------------------E-- ------EVFKVKKSSYSKKIVKQLKKEYKE------------------------------ ----------------------DLEKNK-------------------------------- ------------------------------------------------------------ ---------------------VKPDGN-----------SV-------------------- ------VNAEPTTDKTVLAP-----------------QEDPAGNSEQGEEEMEVDSDNQE EEEED------------------------------------------------------K TKS-TGAFA--------------------------------------------------- -------NAISSLSTLRP-----------GEIPDAAFIHAARKRRQMARELGDGSS-TDL E-MSKGRLVR-ED--ENDA-SD---DDDEKRRIVFSVKEKSQRQKIAEE--IVRTGIEGS DDEALA-TGHQDEELNRWEQEQIRKGISIPQVQTSPPMEMNNMYYQNTYQAMPYGSSYGV PYTY--AAY-----------------------------GAT-EAKPLKAETTVPFKATDN EMTPVTIDLVKKRLKE-RPKVSNLQARKKKNRDSYLKNRKKLTDKTRDVRKLESKKNPMS EYITFSQSLDGEPQYCIQLCYIL------------------------------------- ------------------------QVPLINELESAMYQLLKQRAARLVQRRQDDIKDESS EYSSHS-------------------SKALVAPNLDTFGRDRSHYQEHAKVRRIAERE--- ---ARR-TRR-RQAREQTGKMAEHHEGISSDDEETSTDITNFNMEQ--DRILKESKKVFE DVLEDFYSIDCIKFRFEAWRKMYLTCYQDAYIGLCLSKLFNPLIRLQLITWNPLE----- -------------------------------VKCSDFENMMWFESLLFYGCEEEKA-QQK DDVDVALLPAIIEKVIVAKLTGLAEHIWDPLSTS--------------QTSRFITFLLKL IQGYPSVVNAENRS-----TQALLKAIVLRIRKSLDDDVFIPLYPKNVLENKNSGPYLFF QRQFWSSVKLMNNILQWHGILSNRTLLELAVDSLLNRYILLALQISEPGEDSIKKSQSVI LCFPKQWFTSLKGEKTIPHLENFCRYLVHLANAIYRISVGCSDVEKRNARDQIKQVIKCL ASIHALDHAVALANEY----------------S------------VKDIKALIEGK-- >ENSGMOP00000001987 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------MF----- ------------------------------------------------------------ --------------------KKAKRANLRRRNDSDEDE-------Q-------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---PS------------------------------------------------------- --------------------TP--------------AQTC-------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------G--------------------------------------------- ----------P------------------------------VVEEI-------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------P-------------------------------------------- -----------------------FME---------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------------------TS--- ------------------------------------------------------------ -------------------------FAAVRAAEIQHGNNGFQHNNINHNLKPIKKEKKFK EICPPPAAIA---------------------------APSKAS----------------- ------------------LLSF-DDD--E-EG---------------------------- ---------------------------------------------------------S-- ------EVFRVKKSNYSKKIVKQLKKEYKE------------------------------ ----------------------DLEKTG-------------------------------- ---PVKQEPSS------------------------------------DGP---------- ------------------------------------------------------------ ------------------------------------------------------------ -----------LLPPMMIKEEPRSTVGGDQGVQEMELDGIEVHEEEGNVMA--------- ------------------------------------------------------------ ----GSFNTLSSLSSLRP-----------GEIPDAAFIHAARKRRQLARELGGEPPLVET D-APKKRLTR-EDEEEQDG-SD-DED--DKRINFSGVKNKSQRQKIAEE--I---GIEGS DDEALD-T-GHDEELSRWEQEQIRKGISIPQVQSNPPEDN-TAYYQNSYETQPYGASYNM PYTY--STVTP------------------AVAPAALVSG------------PVPYSGPAA ELAPVSSDLVKKRLRD-R------------------------------------------ ----------------------LGQMRTGHEANAKRYDQIVDELTASDSAIHRLEGSSND NAEQYKFLQEMRGYVGDLLECFGEKVPTILELESAMHQLLRQRAARLVQRRQDDIKDESA EFASLS-------------------SKAVMAPSLDSFGRDRTAYQEHARQRRIAERE--- ---ARR-TRR-RQAREQDGKRAEHREGLSSDDEETSTDITSFDTER--DRIVRECKKVFE DAVEDFHSLDFIKARFEVWRRDYVQCYREAYIGLCLPKLFNPLVRLQLITWSPLQ----- -------------------------------AECANFEYMLWFESLLFYGCEEQGP-LRA GDVDVNLLPAIVEKVLISKLSVLAEQVWDPLSSS--------------QTARLVGFIRRL TRSYPTVLHGDNRY-----TEELLKAVLLRTRRSLDEDVFLPLYPKNVLENKNGGPYLFY ERQFWSCVKLLGNILQFEGILSSSCVRELALDSTLNRYILSALQTTDSTDDSVLKCQQLV QCFPAQWFTGMTGQKTLPQLEPLCRYLTHVASTLYRGSLAASDLERRSLKDQIKEVVKML GQMNALDHIITVATEH----------------G------------IKDIKPLLEAK-S >ENSPLAP00000026770 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------MF----- ------------------------------------------------------------ --------------------KRAKRVNLRRRNDSDEEE-------LEE------------ ------------------------------------------------------------ -----------------SQ----------------------------------------- ------------------------------------------------------------ -PQS-------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------FAP--------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------TSFG--------------------------------------------- ----------P------------------------------VV-EI-------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------P-------------------------------------------- -----------------------FIE---------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------TSGAPSSEENC---------------------------------FNNG FLSNLNIMRPVKKEKKCKEVP--------------------------------------- --------------------------VVVP--------PTKAS----------------- ------------------LLSF-DDD--E-EG---------------------------- ---------------------------------------------------------S-- ------EVFRVKKPNHSKKIVKQLKKEYKE------------------------------ ----------------------DLQKSG-------------------------------- ---NVKQETKS------------------------------------DAPPQPVFTVKEE AI------------------------------------SRGN------------------ --------------------------------------------SEHGEEEMEVES---- GDEQDEEAK--------------------------------------------------- ----------AQE-----------------------------------------GQLSRG RNVGSSFNTLSSLTSLKP-----------GEIPDAAFIHAARKRRQLARELGGEAPLVEA E-PSKKRMTQ-ED---RDC-SD-DEDEDEKRIRFSGVKNKSQRQKIAEE--I---GIEGS DDEALD-T-GQDEEVSRWEQEQIRKGISIPQVQSSQPEDS-TAYYQNSYETQPYGSSYSM PFTY--SSVAPQPGKIPSLSDNGSVRYG-A---------------------------PIC DLTPVSIDLVKKRLQD-R------------------------------------------ ----------------------LDQMHAGHNANIKRYEQIRDELEASESTIQQLEGSSND NADRYKFLQEMRGYVGDLLECFSEKVPAVLELEAAMHQLLRQRAARLVQRRQDDIKDESS EFASLS-------------------NKAVMAPSLDSFGRDRAAYQENSRQRRIAERE--- ---ARR-TRR-RQAREQNGKRAEHKEGLSSDDEETSTDITSFNMER--DRIKAESRKVFE DVVEDFHSLDCIKSRFEVWKREYPDCYRDAYIGLCLPKLFNPLVRLQLITWNPLE----- -------------------------------EPCANFEYMLWFESLLFYGFEEHRT-LEK DDGDIGLLPAIVEKVLLSKLSVLAEQVWDPLSSS--------------QTTRLVSFIHRL AEGYPTVLHGDNQY-----TQELLKSIVLRTRRTLDEDVFLPLYPKNVMDNKNSGAYLFY QRQFWSCVKLLGNIIQWDGILSYSCLKDLALDSTLNRYILSALQSTDIGEENVHKCQKVM ECLPAQWFSGLKGQHTLPQLEPLCRYLTHLANTLHRSSVGASDTERRTTREQVREVVRML GRVNALDHIIAVAEEH----------------G------------VKDIKQLMEVK-- >ENSPMEP00000005879 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------MF----- ------------------------------------------------------------ --------------------KRAKRANLRRRNDSDEDE-------LEE------------ ------------------------------------------------------------ -----------------SQ----------------------------------------- ------------------------------------------------------------ -PQS-------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------FAP--------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------TSFG--------------------------------------------- ----------P------------------------------VV-EI-------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------P-------------------------------------------- -----------------------FIE---------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------TSGAPSSEENC---------------------------------FNNG FLSNLNIMRPVKKEKKCKEVP--------------------------------------- --------------------------VVVP--------PTKAS----------------- ------------------LLSF-DDD--E-EG---------------------------- ---------------------------------------------------------S-- ------EVFRVKKPNHSKKIVKQLKKEYKE------------------------------ ----------------------DLQKSG-------------------------------- ---NVKQETKS------------------------------------DAPPQPVFTVKEE AI------------------------------------SRGN------------------ --------------------------------------------SEHGEEEMEVES---- GDEQNEEAK--------------------------------------------------- ----------AQE-----------------------------------------GQLSRG RNVGSSFNTLSSLTSLKP-----------GEIPDAAFIHAARKRRQLARELGGEAPLVEA E-PSKKRMTQ-ED---RDC-SD-DEDEDEKRIRFSGVKNKSQRQKIAEE--I---GIEGS DDEALD-T-GQDEEVSRWEQEQIRKGISIPQVQSSQPEDS-TAYYQNSYETQPYGSSYSM PFTY--SSVAPQPGKIPSLSDNGSVRYG-A---------------------------PIC DLTPVSIDLVKKRLQD-R------------------------------------------ ----------------------LDQMHAGHNANIKRYEQIRDELEASESTIQQLEGSSND NADRYKFLQEMRGYVGDLLECFSEKVPAVLELEAAMHQLLRQRAARLVQRRQDDIKDESS EFASLS-------------------NKAVMAPSLDSFGRDRAAYQENSRQRRIAERE--- ---ARR-TRR-RQAREQNGKRAEHKEGLSSDDEETSTDITSFNMER--DRIKAESKKVFE DVVEDFHSLDCIKSRFEVWKREYPDCYRDAYIGLCLPKLFNPLVRLQLITWNPLE----- -------------------------------EGCANFEYMLWFESLLFYGFEEHRT-LEK DDGDIGLLPAIVEKVLLSKLSVLAEQVWDPLSSS--------------QTTRLVSFIHRL AEGYPTVLHGDNQY-----TQELLKSIVLRTRRTLDEDVFLPLYPKNVMDNKNSGAYLFY QRQFWSCVKLLGNIIQWDGILSYSCLKDLALDSTLNRYILSALQSTDIGEENVHKCQKVM ECLPAQWFSGLKGQHTLPQLEPLCRYLTHLANTLHRSSVGASDTERRTTREQVREVVRML GRVNALDHIIAVAEEH----------------G------------VKDIKQLMEVK-- >ENSPFOP00000018044 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------MF----- ------------------------------------------------------------ --------------------KRAKRANLRRRNDSDEDE-------LEE------------ ------------------------------------------------------------ -----------------SQ----------------------------------------- ------------------------------------------------------------ -PQS-------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------FAP--------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------TSFG--------------------------------------------- ----------P------------------------------VV-EI-------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------P-------------------------------------------- -----------------------FIE---------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------TSGAPSSEENC---------------------------------FNNG FLSNLNIMRPVKKEKKCKEVP--------------------------------------- --------------------------VVVP--------PTKAS----------------- ------------------LLSF-DDD--E-EG---------------------------- ---------------------------------------------------------S-- ------EVFRVKKPNHSKKIVKQLKKEYKE------------------------------ ----------------------DLQKSG-------------------------------- ---NVKQETKS------------------------------------DAPPQPVFTVKEE AI------------------------------------SRGN------------------ --------------------------------------------SEHGEEEMEVES---- GDEQNEEAK--------------------------------------------------- ----------AQE-----------------------------------------GQLSRG RNVGSSFNTLSSLTSLKP-----------GEIPDAAFIHAARKRRQLARELGGEAPLVEA E-PSKKRMTQ-ED---RDC-SD-DEDEDEKRIRFSGVKNKSQRQKIAEE--I---GIEGS DDEALD-T-GQDEEVSRWEQEQIRKGISIPQVQSSQPEDS-TAYYQNSYETQPYGSSYSM PFTY--SSVAPQPGKIPSLSDNGSVRYG-A---------------------------PIC DLTPVSIDLVKKRLQD-R------------------------------------------ ----------------------LDQMHAGHNANIKRYEQIRDELEASESTIQQLEGSSND NADRYKFLQEMRGYVGDLLECFSEKVPAVLELEAAMHQLLRQRAARLVQRRQDDIKDESS EFASLS-------------------NKAVMAPSLDSFGRDRAAYQENSRQRRIAERE--- ---ARR-TRR-RQAREQNGKRAEHKEGLSSDDEETSTDITSFNMER--DRIKAESKKVFE DVVEDFHSLDCIKSRFEVWKREYPDCYRDAYIGLCLPKLFNPLVRLQLITWNPLE----- -------------------------------EPCANFEYMLWFESLLFYGFEEHRT-LEK DDGDIGLLPAIVEKVLLSKLSVLAEQVWDPLSSS--------------QTTRLVSFIHRL AEGYPTVLHGDNQY-----TQELLKSIVLRTRRTLDEDVFLPLYPKNVMDNKNSGAYLFY QRQFWSCVKLLGNIIQWDGILSYSCLKDLALDSTLNRYILSALQSTDIGEENVHKCQKVM ECLPAQWFSGLKGQHTLPQLEPLCRYLTHLANTLHRSSVGASDTERRTTREQVREVVRML GRVNALDHIIAVAEEH----------------G------------VKDIKQLMEVK-- >ENSPREP00000021954 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------MF----- ------------------------------------------------------------ --------------------KRAKRANLRRRNDSDEDE-------LEE------------ ------------------------------------------------------------ -----------------SQ----------------------------------------- ------------------------------------------------------------ -PQS-------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------FAP--------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------TSFG--------------------------------------------- ----------P------------------------------VV-EI-------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------P-------------------------------------------- -----------------------FIE---------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------TSGAPSSEENC---------------------------------FSNG FLSNLNTMRPVKKEKKCKEVP--------------------------------------- --------------------------VVVP--------PTKAS----------------- ------------------LLSF-DDD--E-EG---------------------------- ---------------------------------------------------------S-- ------EVFRVKKPNHSKKIVKQLKKEYKE------------------------------ ----------------------DLQKSG-------------------------------- ---NVKQETKS------------------------------------DAPPQPVFTVKEE AI------------------------------------SRGN------------------ --------------------------------------------SEHGEEEMEVES---- GDEQNEEAK--------------------------------------------------- ----------AQG-----------------------------------------GQLSRG RNVGSSFNTLSSLTSLKP-----------GEIPDAAFIHAARKRRQLARELGGEAPLVEA E-PSTKRMTQ-ED---RDC-SD-DEDEDEKRIRFSGVKNKSQRQKIAEE--I---GIEGS DDEALD-T-GQDEEVSRWEQEQIRKGISIPQVQSSQPEDN-TAYYQNSYETQPYGSSYSM PFTY--SSVAPQPGKIPSLSDNGSVRYG-A---------------------------PIC DLTPVSIDLVKKRLQD-R------------------------------------------ ----------------------LAQMHAGHNANIKRYEQIRDELEASESTILQLEGSSND NADRYKFLQEMRGYVGDLLECFSEKVPAVLELEAAMHQLLRQRAARLVQRRQDDIKDESS EFASLS-------------------NKAVMAPSLDSFGRDRAAYQENSRQRRIAERE--- ---ARR-TRR-RQAREQNGKRAEHKEGLSSDDEETSTDITSFNMER--DRIKGESKKIFE DAVEDFHSLDCIKSHFEVWRREYPDCYRDAYIGLCLPKLFNPLVRMQLITWNPLE----- -------------------------------EPCANFEYMLWFESLLFYGFEEHRT-LEK DDGDIGLLPAIVEKVLLSKLSVLAEQVWDPLSSS--------------QTTRLVSFIHRL AEGYPTVLHGDNQY-----TQELLKTIVLRTRRTLDEDVFLPLYPKNVMDNKNSSAYLFY QRQFWSCVKLLGNIIQWDGILSYSCLKDLALDSTLNRYILSALQSTDVGEENVQKCQKVM ECLPAQWFSGLKGQHTLPQLEPLCRYLTHLANTLHRSSVGASDNERRTTREQVREVVRML GRVNALDHIIAVAEEH----------------G------------VKDIKQLMEVK-- >ENSGAFP00000026355 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------MF----- ------------------------------------------------------------ --------------------KRAKRVNLRRRNDSDEDE-------QEE------------ ------------------------------------------------------------ -----------------SQ----------------------------------------- ------------------------------------------------------------ -PQS-------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------FAP--------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------TSFG--------------------------------------------- ----------P------------------------------VV-EI-------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------P-------------------------------------------- -----------------------FIE---------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------TSGAPSSDESC---------------------------------FSNG FLSNLNIMRPVKKEKKCKEVP--------------------------------------- --------------------------VVVP--------PTKAS----------------- ------------------LLSF-DDD--E-EG---------------------------- ---------------------------------------------------------S-- ------EVFRVKKPNHSKKIVKQLKKEYKE------------------------------ ----------------------DLQKSG-------------------------------- ---NVKQETKS------------------------------------DAPPQPVFTVKEE AI------------------------------------SRGT------------------ --------------------------------------------SEQGEEAMEVES---- GDEQDGEAK--------------------------------------------------- ----------AQG-----------------------------------------GQLSRG RNVGSSFNTLSSLTSLKP-----------GEIPDAAFIHAARKRRQLARELGGEAPLVEA E-PSKKRMTQ-ED---RDC-SD-DEDEDEKRIRFSGVKNKSQRQKIAEE--I---GIEGS DDEALD-T-GQDEEVSRWEQEQIRKGISIPQVQSSQPEDS-TAYYQNSYETQPYGSSYSL PFTY--SSVAPQPGKIPSLSDNGSVRYG-A---------------------------PIC DLTPVSIDLVKKRLQD-R------------------------------------------ ----------------------LAQMHAGHNANVKRYEQIRDELEASESTIQQLEGSSND NADRYKFLQEMRGYVGDLLECFSEKVPAVLELEAAMHQLLRQRAARLVQRRQDDIKDESS EFASLS-------------------NKAVMAPSLDSFGRDRAAYQENSRQRRIAERE--- ---ARR-TRR-RQAREQNGKRAEHKEGLSSDDEETSTDITSFNMER--DRIKADSKKVFE DVVEDFHSLDCIKSRFEVWRREYPDCYRDAYIGLCLPKLFNPLVRLQLITWNPLE----- -------------------------------EPCANFEYMLWFESLLFYGFEEHRT-LEK DDGDIGLLPAIVEKVLLSKLSVLAEQVWDPLSSS--------------QTTRLVSFIHRL AEGYPTVLHGDNQY-----TQELLKAIVLRTRRTLDEDAFLPLYPKTVMDNKNSGAYLFY QRQFWSCVKLLGNIIQWDGVLSYSCLKDLALDSTLNRYILSALQSTDVGEENVQKCQKVV ECLPAQWFSGLKGQHTLPQLEPLCRYLTHLANTLHRSSVGASDTERRTTREQVREVVRML GRVNALDHIIAVAEEH----------------G------------VKDIKQLMEVK-- >ENSXCOP00000024043 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------MF----- ------------------------------------------------------------ --------------------KRAKRANLRRRNDSDEDE-------QEE------------ ------------------------------------------------------------ -----------------SQ----------------------------------------- ------------------------------------------------------------ -PQS-------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------FAP--------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------TSFG--------------------------------------------- ----------P------------------------------VV-EI-------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------P-------------------------------------------- -----------------------FIE---------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------TSRAPSSEENC---------------------------------FSNG FLSNLNIMRPVKKEKKCKEVP--------------------------------------- --------------------------VVVP--------PTKAS----------------- ------------------LLSF-DDD--E-EG---------------------------- ---------------------------------------------------------S-- ------EVFRVKKPNHSKKIVKQLKKEYKE------------------------------ ----------------------DLQKSG-------------------------------- ---N------------------------------------------------PVFTVKEE PI------------------------------------SRGS------------------ --------------------------------------------SEQGEEEMEVES---- GDEQDVEAK--------------------------------------------------- ----------AQG-----------------------------------------GQLSRG RNVGSSFNTLSSLTSLKP-----------GEIPDAAFIHAARKRRQLARELGGEAPLVEA E-PSKKRMAQ-ED---RDC-SD-DEDEDEKRIRFSGVKNKSQRQKIAEE--I---GIEGS DDEALD-T-GQDEEVSRWEQEQIRKGISIPQVQSSQPEDS-TAYYQNSYETQPYGSSYSM PFTY--SSVAPQPGKIPSLSDNGSVRYG-A---------------------------PIC DLTPVSIDLVKERMQD-R------------------------------------------ ----------------------LAQMHAGHNANIKRYEQISDELEASESTIQQLEGSSND NADRYKFLQEMRGYVGDLLECFSEKVPAVLELEAAMHQLLRQRAARLVQRRQDDIKDESS EFASLS-------------------NKAVMAPSLDSFGRDRAAYQENSRQRRIAERE--- ---ARR-TRR-RQAREQNGKRAEHKEGLSSDDEETSTDITSFNMER--DRIKADSKKVFE DVVEDFHSLDCIKSHFEVWRREYPDCYRDAYIGLCLPKLFNPLVRLQLITWNPLE----- -------------------------------EPCANFEYMLWFESLLFYGFEEHRT-LEK DDGDIGLLPAIVEKVLLSKLSVLAEQVWDPLSSS--------------QTTRLVSFIHRL AEGYPTVLHGDNQY-----TQELLKTIVLRTRRTLDEDVFLPLYPKNVMDNKNSSAYLFY ERQFWSCVKLLGNIIQWDGILSYSCLKDLALDSTLNRYILSALQSTDVGEENVQKCQKVV ECLPAQWFSGMKGQHTLPQLEPLCRYLTHLANTLHRSSVGAPDTERRT---QVREVVRML GRVNALDHIIAVAEEH----------------G------------VKDIKQLMEVK-- >ENSXMAP00000016088 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------MF----- ------------------------------------------------------------ --------------------KRAKRANLRRRNDSDEDE-------QEE------------ ------------------------------------------------------------ -----------------SQ----------------------------------------- ------------------------------------------------------------ -PQS-------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------FAP--------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------TSFG--------------------------------------------- ----------P------------------------------VV-EI-------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------P-------------------------------------------- -----------------------FIE---------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------TSRAPSSEENC---------------------------------FSNG FLSNLNIMRPVKKEKKCKEVP--------------------------------------- --------------------------VVVP--------PTKAS----------------- ------------------LLSF-DDD--E-EG---------------------------- ---------------------------------------------------------S-- ------EVFRVKKPNHSKKIVKQLKKEYKE------------------------------ ----------------------DLQKSG-------------------------------- ---N------------------------------------------------PVFTVKEE PI------------------------------------SRGS------------------ --------------------------------------------SEQGEEEMEVES---- GDEQDVEAK--------------------------------------------------- ----------AQG-----------------------------------------GQLSRG RNVGSSFNTLSSLTSLKP-----------GEIPDAAFIHAARKRRQLARELGGEAPLVEA E-PSKKRMAQ-ED---RDC-SD-DEDEDEKRIRFSGVKNKSQRQKIAEE--I---GIEGS DDEALD-T-GQDEEVSRWEQEQIRKGISIPQVQSSQPEDS-TAYYQNSYETQPYGSSYSM PFTY--SSVAPQPGKIPSLSDNGSVRYG-A---------------------------PIC DLTPVSIDLVKKRLQD-R------------------------------------------ ----------------------LAQMHAGHNANIKRYEQISDELEASESTIQQLEGSSND NADRYKFLQEMRGYVGDLLECFSEKVPAVLELEAAMHQLLRQRAARLVQRRQDDIKDESS EFASLS-------------------NKAVMAPSLDSFGRDRAAYQENSRQRRIAERE--- ---ARR-TRR-RQAREQNGKRAEHKEGLSSDDEETSTDITSFNMER--DRIKADSKKVFE DVVEDFHSLDCIKSHFEVWRREYPDCYRDAYIGLCLPKLFNPLVRLQLITWNPLE----- -------------------------------EPCANFEYMLWFESLLFYGFEEHRT-LEK DDGDIGLLPAIVEKVLLSKLSVLAEQVWDPLSSS--------------QTTRLVSFIHRL AEGYPTVLHGDNQY-----TQELLKTIVLRTRRTLDEDVFLPLYPKTVMDNKNSSAYLFY ERQFWSCVKLLGNIIQWDGILSYSCLKDLALDSTLNRYILSALQSTDVGEENVQKCQKVV ECLPAQWFSGMKGQHTLPQLEPLCRYLTHLANTLHRSSVGAPDTERRTAREQVREVVRML GRVNALDHIIAVAEEH----------------G------------VKDIKQLMEVK-- >ENSFHEP00000032161 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------MF----- ------------------------------------------------------------ --------------------KKAKRVNLRRRNDSDEDE-------LEA------------ ------------------------------------------------------------ -----------------GQ----------------------------------------- ------------------------------------------------------------ -PQT-------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------AAP--------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------TLFG--------------------------------------------- ----------P------------------------------VV-EI-------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------P-------------------------------------------- -----------------------FIE---------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------TSAAPSSEENS---------------------------------YSNG FLANLNNVRPVKREKKSKDVA--------------------------------------- --------------------------VLAP--------PTKAS----------------- ------------------LLSFDDDD--E-EG---------------------------- ---------------------------------------------------------S-- ------EVFRVKKPNHSKKIVKQLKKEYKE------------------------------ ----------------------DLQKTG-------------------------------- ---N--------------------------------------------APPQLVFTVKEE VI------------------------------------SRAS------------------ --------------------------------------------SEHGEEEMEVES---- ADEQDEEAK--------------------------------------------------- ----------AQG-----------------------------------------GQLSRG RNVGASFNTLSSLTSLKP-----------GEIPDAAFIHAARKRRQLARELGGEAPLVEP E-PSKKHLTR-DD---RDG-SD-DEDEDEKRIRFSGVKNKSQRQKIAEE--I---GIEGS DDEALD-T-GQDEEVSRWEQEQIRKGISIPQVQSSQPEDS-TVYYQNSYETQPYGSSYSM PFTY--STVAPQPGKMPCLSDNGSVHYG-A---------------------------PIC DLTPVSIDLVKKRLQD-R------------------------------------------ ----------------------LVQMHAGHNANITRYEQIRDDLAASESAIQQLEGSSND NADRYKFLQEMRGYVGDLLECFSEKVPAVLELEAAMHQLLRQRAARLAQRRQDDIKDESS EFASLS-------------------NKAVMAPSLDSFGRDRAAYQEHSRQRRIAERE--- ---ARR-TRR-RQAREQNGKRAEHKEGLSSDDEETSTDVTTFNMER--DRIRAESKKVFE DVVEDFHSLDCIKTRFEAWRKEYPDCYRDAYIGLCLPKLFNPLVRLQLITWNPLE----- -------------------------------EPCANFEYMLWFESLLFYGFEENKL-LHK EDGDIGLLPAIVEKVLLSKLSVLAEQVWDPLSSS--------------QTARLVSFIHRL AEGYPTVLHGDNLY-----TQELLKTIVLRTRRTLDEDVFLPLYPKNVMDNKNSGAYLFY QRQFWSCIKLLGNIVQWDGILSYSCLKDLALDSTLNRYILSALQSTDIGEENVQKCQKVV ECLPPQWFSGLKGQQTLPQLEPLCRYLTHLANTLHRSTVGASDVERRTAKEQIREVVKML GRVNALDHIIAVAEEH----------------G------------VKDIKQLLEVK-- >ENSOMEP00000031332 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------MF----- ------------------------------------------------------------ --------------------KRAKRANFRRRNDSEEDE-------QEP------------ ------------------------------------------------------------ -----------------GQ----------------------------------------- ------------------------------------------------------------ -PQA-------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------LVP--------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------MSFG--------------------------------------------- ----------P------------------------------AV-EI-------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------P-------------------------------------------- -----------------------FME---------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------KSSG-------GGT------------------ ------------------------------------------------------------ --GAPSGTDTLH---------------------------------------------SNG FLANINIAKPVKKEKKIKEAP--------------------------------------- --------------------------ALPL--------PAKVS----------------- ------------------LLSF-DEE--E-EA---------------------------- ---------------------------------------------------------T-- ------EVFRVKKPNHSKKIVKQLKKEYKE------------------------------ ----------------------DLERSG-------------------------------- ---SGKHETKT------------------------------------DAPSKPVFAIKEE IT------------------------------------SRDN------------------ --------------------------------------------SEHGEEEMEVDS---- -D---------------------------------------------------------- ------------------------------------------DEESKSQNAPTHAQMSRS LNPAGTFNTLSSLSSLKP-----------GEIPDAAFIHAARKRRQLARELGGDAPLVQM D-TPQKRLDQ-ED---QDA-SD-D-DEDEKRIRFSGVKNKTQRQKIAEE--I---GIEGS DDEALDAA-GHDEEVSRWEQEQIRKGISIPQVQSSQPEET-PVYYQNSYETQPYGSSYSM PFTY--STVTPQTAKLPSLSNNGSVHYG-R---------------------------PIC DLTPISIDLVKKRLQE-R------------------------------------------ ----------------------LGHMHTGHNANVKRYKQIKEDLAASESVIQQLEGSSNN NAEQYKFLQEMRGYVGDLLECFSEKVPAVLELEAAMHQLLRQRASRLVQRRQDDIKDESA EFASLS-------------------NKAVMAPSLDSLGRDRAAYQEHNRQRRIAERE--- ---ARR-TRR-RQAREQNGKRAEHKEGLSSDDEETSTDITSFDMEK--DRIVRESKKIFE DVLEDFHSLDCIKDRFEEWRKEYPGCYRDAYIGLCLPRLFSPLVRLQLITWNPLE----- -------------------------------VPCANFEYMLWFESLLFYGFDEHST-LEK DDGDIGLLPAIVEKVILSKLSVLAEQVWDPLSSS--------------QTARLVAFIHRL LKGYPTVLHGDNRF-----TQELLKMIVLRTRRTLDEDIFLPLYPKNVMDNKNSGAYLFY QRQFWSCVKLLGNILRWEGILSTSCLKDLALDSTLNRYILSALQTTDVGEENVHKCQKVV ECLPVHWFSGLKGQQTLPQLEPLCRYLAHLANCLHRNSIGLSDIERRTSKEQIRDIVKML RLVNALDHIVAVAAEQ----------------G------------IKDIKQLMEVK-S >ENSORLP00000006101 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------MF----- ------------------------------------------------------------ --------------------KRAKRANFRRRNDSEEDE-------QEQ------------ ------------------------------------------------------------ -----------------SQ----------------------------------------- ------------------------------------------------------------ -PQA-------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------LVP--------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------MSFG--------------------------------------------- ----------P------------------------------AV-EI-------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------P-------------------------------------------- -----------------------FME---------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------KSS--------GGS------------------ ------------------------------------------------------------ --GALSGTDNVH---------------------------------------------SNG FLANINNAKGVKKEKKCKETP--------------------------------------- --------------------------VQPL--------PAKVS----------------- ------------------LLSF-DEE--E-EA---------------------------- ---------------------------------------------------------T-- ------EVFRVKKPNHSKKIVKQLKKEYKE------------------------------ ----------------------DLEKGG-------------------------------- ---SGKQESKT------------------------------------GAPSKPMFAIKEE VI------------------------------------SREN------------------ --------------------------------------------SEHGEEEMEVDS---- -DEQDEEAR--------------------------------------------------- ----------SQGVPTRGQ------------------IPKSI------------------ -NPGGTFNTLSSLSSLKP-----------GEIPDAAFIHAARKRRQLARELGGEAPLVQM D-TPQKRLDQ-ED---QDA-SD-D-DEDEKRIRFSGVKNKTQRQKIAEE--I---GIEGS DDEALDAA-GQDEEVSRWEQEQIRKGISIPQVQSSQPEEP-TVYYQNSYETQPYGSSYSM PFTY--STVALQTAKLPSLSNNGSVHYG-R---------------------------PIC ELTPIPIDLVKKRLQE-R------------------------------------------ ----------------------LGHMHAGHNANVKRYTQIKEDLAASESVIQQLEGSSNN NAEQYKFLQEMRGYVGDLLECFNEKVPAVLELEAAMHQLLRQRASRLVQRRQDDIKDESA EFASLS-------------------NKAVMAPSLDSFGRDRAAYQEHSRQRRIAERE--- ---ARR-TRR-RQAREQNGKRAEHKEGLSSDDEETSTDITSFNMEK--DRIVWESKKIFE DVLEDFHSLDCMKNRFEEWRKEYPTCYRDAYIALCLPRLFSPLVRLQLITWNPLE----- -------------------------------VPCANFEYMLWFESLLFYGFDEHST-LQK EDGDIGLLPAIVEKVILSKLSVLAEQVWDPLSSS--------------QTARLVAFIHRL RKGYPTVLHGDNRY-----TQELLKMIVLRTRRTLDEDIFLPLYPKNVMDNKNSGAYLFY QRQFWSCVKLLGNILQWEGILSTSCLMDLALDSTLNRYILSALQTTDVGEENVHKCQKVV ECLPVHWFSGLKGQQTLPQLEPLCRYLAHLANSLHRSNIGVSDIERRTSKEQIRDIVKML RLVNALDHIVAVAAEQ----------------G------------IKDLKQLMEVK-S >ENSORLP00015015404 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------MF----- ------------------------------------------------------------ --------------------KRAKRANFRRRNDSEEDE-------QEL------------ ------------------------------------------------------------ -----------------SQ----------------------------------------- ------------------------------------------------------------ -PQA-------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------LVP--------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------MSFG--------------------------------------------- ----------P------------------------------TV-EI-------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------P-------------------------------------------- -----------------------FME---------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------KSS--------GGS------------------ ------------------------------------------------------------ --GAPSGTDNVH---------------------------------------------SNG FLANINNAKGVKKEKKCKETP--------------------------------------- --------------------------VQPL--------PAKVS----------------- ------------------LLSF-DEE--E-EA---------------------------- ---------------------------------------------------------T-- ------EVFRVKKPNHSKKIVKQLKKEYKE------------------------------ ----------------------DLEKGG-------------------------------- ---SGKQESKT------------------------------------GAPSKPMFAIKEE VI------------------------------------SREN------------------ --------------------------------------------SEHGEEEMEVDS---- -DEQDEEAR--------------------------------------------------- ----------SQGVPTRGQ------------------IPKSI------------------ -NPGGTFNTLSSLSSLKP-----------GEIPDAAFIHAARKRRQLARELGGEAPLVQM D-TPQKRLDQ-ED---QDA-SD-D-DEDEKRIRFSGVKNKTQRQKIAEE--I---GIEGS DDEALDAA-GQDEEVSRWEQEQIRKGISIPQVQSSQPEEP-TVYYQNSYETQPYGSSYSM PFTY--STVALQTAKLPSLSNNGSVHYG-R---------------------------PIC ELTPIPIDLVKKRLQE-R------------------------------------------ ----------------------LGHMHAGHNANVKRYTQIKEDLAASESVIQQLEGSSNN NAEQYKFLQEMRGYVGDLLECFSEKVPAVLELEAAMHQLLRQRASRLVQRRQDDIKDESA EFASLS-------------------NKAVMAPSLDSFGRDRAAYQEHSRQRRIAERE--- ---ARR-TRR-RQAREQNGKRAEHKEGLSSDDEETSTDITSFNMEK--DRIFRESKKIFE DVLEDFHSLDCMKNRFEEWRKEYPTCYRDAYIALCLPRLFSPLVRLQLITWNPLE----- -------------------------------VPCANFEYMLWFESLLFYGFDEHST-LQK EDGDIGLLPAIVEKVILSKLSVLAEQVWDPLSSS--------------QTARLVAFIHRL RKGYPTVLHGDNRY-----TQELLKMIVLRTRRTLDEDIFLPLYPKNVMDNKNSGAYLFY QRQFWSCVKLLGNILQWEGILSTSCLMDLALDSTLNRYILSALQTTDVGEENVHKCQKVV ECLPVHWFSGLKGQQTLPQLEPLCRYLAHLANSLHRSNIGVSDIERRTSKEQIRDIVKML RLVNALDHIVAVAAEQ----------------G------------IKDLKQLMEVK-S >ENSORLP00020009799 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------MF----- ------------------------------------------------------------ --------------------KRAKRANFRRRNDSEEDE-------QEQ------------ ------------------------------------------------------------ -----------------SQ----------------------------------------- ------------------------------------------------------------ -PQA-------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------LVP--------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------MSFG--------------------------------------------- ----------P------------------------------AV-EI-------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------P-------------------------------------------- -----------------------FME---------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------KSS--------GGP------------------ ------------------------------------------------------------ --GALSSTDNVH---------------------------------------------SNG FLANINIAKGVKKEKKCKETP--------------------------------------- --------------------------VQPL--------PAKVS----------------- ------------------LLSF-DEE--E-EA---------------------------- ---------------------------------------------------------T-- ------EVFRVKKPNHSKKIVKQLKKEYKE------------------------------ ----------------------DLEKGG-------------------------------- ---SGKQESKI------------------------------------GAPSKPMFAIKEE VI------------------------------------SREN------------------ --------------------------------------------SEHGEEEMEVDS---- -DEQDEEAR--------------------------------------------------- ----------SQGVPTRGQ------------------IPKSI------------------ -NPGGTFNTLSSLSSLKP-----------GEIPDAAFIHAARKRRQLARELGGEAPLVQM D-TPQKRLDQ-ED---QDA-SD-D-DEDEKRIRFSGVKNKTQRQKIAEE--I---GIEGS DDEALDAA-GQDEEVSRWEQEQIRKGISIPQVQSSQPEEP-TVYYQNSYETQPYGSSYSM PFTY--STVALQTAKLPSLSNNGSLHYG-R---------------------------PIC ELTPIPIDLVKKRLQE-R------------------------------------------ ----------------------LGHMHAGHNANVKRYTQIKEDLAASESLIQQLEGSSNN NAEQYKFLQEMRGYVGDLLECFSEKVPAVLELEAAMHQLLRQRASRLVQRRQDDIKDESA EFASLS-------------------NKAVMAPSLDSFGRDRAAYQEHSRQRRIAERE--- ---ARR-TRR-RQAREQNGKRAEHKEGLSSDDEETSTDITSFNMEK--DRIVWESKKIFE DVLEDFHSLDCMKNRFEEWRKEYPTCYRDAYIALCLPRLFSPLVRLQLITWNPLE----- -------------------------------VPCANFEYMLWFESLLFYGFDEHST-LQK EDGDIGLLPAIVEKVILSKLSVLAEQVWDPLSSS--------------QTARLVAFIHRL RRGYPTVLHGDNRY-----TQELLKMIVLRTRRTLDEDIFLPLYPKNVMDNKNSGAYLFY QRQFWSCVKLLGNILQWEGILSTSCLMDLALDSTLNRYILSALQTTDVGEENVHKCQKVV ECLPVHWFSGLKGQQTLPQLEPLCRYLAHLANSLHRSNMGVSDIERRTSKEQIRDIVKML RLVNALDHIVAVAAEQ----------------G------------IKDLKQLMEVK-S >ENSMAMP00000028566 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------MF----- ------------------------------------------------------------ --------------------KKAKRANFRRRNDSDEDE-------QEE------------ ------------------------------------------------------------ -----------------GQQ--------------------PP------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------VAP--------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------TPFG--------------------------------------------- ----------P------------------------------AGEEI-------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------P-------------------------------------------- -----------------------FME---------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------------------TSSNS ITGAPGSTDTCH---------------------------------------------SNG LQANLNIVRVAKKEKKSKD----------------------------------------- --------------------------------IAPVPGPTKAS----------------- ------------------LLSF-DDE--E-EG---------------------------- ---------------------------------------------------------S-- ------EVFRVKKSNHSKKIVKQLKKEYKE------------------------------ ----------------------DLERSG-------------------------------- ---CVKHEAKS------------------------------------DAPTQPLVAIKEE VT------------------------------------SRAG------------------ --------------------------------------------SEQGEEEMEVDS---- ADEQEDDTK--------------------------------------------------- ----------SQG----GQAH---------------------------------SQVSRS NSSGATFNTISSLGSLRP-----------GEIPDAAFIHAARKRRQMARELGGETPLIET E-APKKRLVR-ED---QDV-SD-DEDEEEKRIRFSGVRNKSQRQKIAEE--I---GIQGS DDEALD-T-GQDEEVSRWEQEQIRKGISIPQVQSTQPEDN-TVYYQNSYESQPYGSSYSM AFTY--STVAPQTGKPPGRADNGSVHYV-A---------------------------PIS DLAPVSTDLVKKRLRD-R------------------------------------------ ----------------------LSQMCAGHNANAKRYKQIEEDLAASESTIQQLEASSND NADQYKFLQEMRGYVGDLLECFSEKVPAVLELEAAMHQLLRQRASRLVQRRQDDIKDESS EFASLS-------------------NKAVMAPNLDSFGRDRAAYQEHSRQRRIAERE--- ---ARR-TRR-RQAREQNGKRTEHKEGLSSDDEETSTDITSFNMEK--DRIIRECKKVFE DVVEDFHSLDFIKSHFEVWRRDYADSYRDAYIGLCLPKLFNPLVRLQLITWNPLE----- -------------------------------TQCANFEYMLWFESLLFYGFEEHST-LQR GDGDIGLLPAIVEKVILSKLTVLAEQVWDPLSSS--------------QTTRLVGFIQRL MKGYPTVLHGDNRY-----TQELLKTIVLRTRRTLDEDVFLPLYPKNVLENKNSSPYLFY ERQFWSCVKLLGNILQWEGILSSSCLKDLALDSTLNRYILSALQTTDTAEDNVQKCQKVV ESLPAHWFSGLKNQQTLPQLEPFCRYLAHLANSLYRSTMGKSDVERRTAKEQVKEVVKML GHMNALDHIVTVASEH----------------G------------IKDIKTLLEAK-S >ENSSLDP00000020401 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------MF----- ------------------------------------------------------------ --------------------KKAKRANFRRRNESDEDE-------QEE------------ ------------------------------------------------------------ -----------------SQL--------------------PP------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------LAP--------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------TSFG--------------------------------------------- ----------P------------------------------VVEEI-------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------P-------------------------------------------- -----------------------FME---------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------------------TSNNS LAGAPSSTENYH---------------------------------------------SNG FQSNPNSVRAVKREKKIKE----------------------------------------- --------------------------------TAAVPGPTKAS----------------- ------------------LLSF-NDD--E-EG---------------------------- ---------------------------------------------------------S-- ------EVFRVKKSNHSKKIVKQLKKEYKE------------------------------ ----------------------DLEKSG-------------------------------- ---C------------------------------------------------LPVAIKEE VT------------------------------------SRAG------------------ --------------------------------------------SEQGEEEMEVDS---- ADEQEEEAR--------------------------------------------------- ----------GQG----GQAQ--------------------------------------- ------------------SQFKTCFSFILGEIPDAAFIHAARKRRQMARELGGEAPLVET E-TPKKRLVR-ED---QDA-SD-DEDEEEKRIRFSGVRNKSQRQKIAEE--I---GIEGS DDEALD-T-GQDEEVSRWEQEQIRKGISIPQVQSNQPEDN-TVYYQNSYETQPYGSSYSM PFTY--STVAPPTGKPTGRADNGSVHYG-A---------------------------PIS DLTPVSIDLVKKRLQD-R------------------------------------------ ----------------------LSQMHAGHNANAKRYKQIEDDLAASESTIQQLEGSSND NADQYKFLQEMRGYVGDLLECFSEKVPAVLELEAAMHQLLRQRASRLVQRRQDDIKDESS EFASLS-------------------NKAVMAPNLDSFGRDRAAYQEHSRQRRIAERE--- ---ARR-TRR-RQAREQNGKRAEHKEGLSSDDEETSTDITSFNMER--DRIVRECKKVFE DVVEDFHSLDCIKSHFEVWRRDYADCYRDAYIGLCLPKLFNPLVRLQLITWNPLE----- -------------------------------AQCANFEYMLWFESLLFYGFEEHST-LQS GDGDIILLPAIVEKVILSKLTVLTEQVWDPLSSS--------------QTARLVGFVHRL MKGYPTVLQGDNRY-----TQELLKTIVLRTRRTLDEDVFLPLYPKNVLENKNSGPYLFY QRQFWSCVKLLGDILQWDGILSSSCLKDLALDSTLNRYILSALQTTDTAEDNVQKCQKVV ECLPVQWFSGLKGQQTLPQLEPFCRYLTHLANSLHRSSVGGSDVERRS----VKELVKML GHMNGLDHIITLAAEH----------------G------------IKDIKPLLEAK-S >ENSSDUP00000004156 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------MF----- ------------------------------------------------------------ --------------------KKAKRANFRRRNESDEDE-------QEE------------ ------------------------------------------------------------ -----------------SQL--------------------PP------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------LAP--------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------TSFG--------------------------------------------- ----------P------------------------------VVEEI-------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------P-------------------------------------------- -----------------------FME---------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------------------TSNNS LAGAPSSTENYH---------------------------------------------SNG FQGNPNSVRAVKREKKIKE----------------------------------------- --------------------------------TAAVPGPTKAS----------------- ------------------LLSF-NDD--E-EG---------------------------- ---------------------------------------------------------S-- ------EVFRVKKSNHSKKIVKQLKKEYKE------------------------------ ----------------------DLEKSG-------------------------------- ---CVKQEIKS------------------------------------DAPLQLPVAIKEE VT------------------------------------SRAG------------------ --------------------------------------------SEQGEEEMEVDS---- ADEQEEEAR--------------------------------------------------- ----------GQG----GQAQ---------------------------------GQVSKS NNAGANFNTLSSLGSLKP-----------GEIPDAAFIHAARKRRQMARELGGEAPLVET E-APKKRLVR-ED---QDA-SD-DEDEEEKRIRFSGVRNKSQRQKIAEE--I---GIEGS DDEALD-T-GQDEEVSRWEQEQIRKGISIPQVQSNQPEDN-TVYYQNSYETQPYGSSYSM PFTY--STVAPPTGKPTGRADNGSVHYG-A---------------------------PIS DLTPVSIDLVKKRLQD-R------------------------------------------ ----------------------LSQMHAGHNANAKRYKQIEDDLAASESTIQQLEGSSND NADQYKFLQEMRGYVGDLLECFSEKVPAVLELEAAMHQLLRQRASRLVQRRQDDIKDESS EFASLS-------------------NKAVMAPNLDSFGRDRAAYQEHSRQRRIAERE--- ---ARR-TRR-RQAREQNGKRAEHKEGLSSDDEETSTDITSFNMER--DRIVRECKKVFE DVVEDFHSLDCIKSHFEVWRRDYADCYRDAYIGLCLPKLFNPLVRLQLITWNPLE----- -------------------------------AQCANFEYMLWFESLLFYGFEEHST-LQS GDGDIILLPAIVEKVILSKLTVLTEQVWDPLSSS--------------QTARLVGFVHRL MKGYPTVLQGDNRY-----TQELLKTIVLRTRRTLDEDVFLPLYPKNVLENKNSGPYLFY QRQFWSCVKLLGDILQWDGILSSSCLKDLALDSTLNRYILSALQTTDTAEDNVQKCQKVV ECLPVQWFSGLKGQQTLPQLEPFCRYLTHLANSLHRSSVGGSDVERRSAKDQVKELVKML GHMNGLDHIITLAAEH----------------G------------IKDIKPLLEAK-S >ENSLCAP00010022547 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------MF----- ------------------------------------------------------------ --------------------KKAKRANFRRRNESDEDE-------QEE------------ ------------------------------------------------------------ -----------------SQQ--------------------PP------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------LA---------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------SFG--------------------------------------------- ----------P------------------------------VVEEI-------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------P-------------------------------------------- -----------------------FME---------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------------------TSFNS ITGAPSSTDSYH---------------------------------------------SNG FQANLNSARVVKKEKKGKE----------------------------------------- --------------------------------TATVPGPTKAS----------------- ------------------LLSF-NDD--E-EG---------------------------- ---------------------------------------------------------S-- ------EVFRVKKSNHSKKIVKQLKKEYKE------------------------------ ----------------------DLERSG-------------------------------- ---YVKQEIKS------------------------------------DAPPQPPVAIKEE VT------------------------------------SRAG------------------ --------------------------------------------SEQGEEEMEVDS---- ADEQEEEAK--------------------------------------------------- ----------SQG----GQAH---------------------------------SQVSKS NNTGTNFNTLSSLGSLRP-----------GEIPDAAFIHAARKRRQMARELGGETPLVET E-TPKKRLVR-ED---QDA-SD-DEDEEEKRIRFSGVRNKSQRQKIAEE--I---GIEGS DDEALD-T-GQDEEVSRWEQEQIRKGISIPQVQSNQPEDN-TVYYQNSYESQPYGSSYSM PFTY--STVAPQTGKPTGRADNGSVHYG-A---------------------------PIS DLTPVPIDLVKKRLQD-R------------------------------------------ ----------------------LSQMRAGHNANAKRYKQIEEDLAASEGTIQQLEGSSND NADQYKFLQEMRGYVGDLLECFSEKVPAVLELEAAMHQLLRQRASRLVQRRQDDIKDESS EFASLS-------------------NKAVMAPNLDSFGRDRAAYQEHSRQRRIAERE--- ---ARR-TRR-RQAREQNGKRAEHKEGLSSDDEETSTDITSFNMER--DRIIRECKKVFE DVVEDFHSLDCIKSHFEVWRRDYADCYRDAYIGLCLPKLFNPLVRLQLITWNPLE----- -------------------------------AQCANFEYMLWFESLLFYGFEEHST-LQR GDGDISLLPAIVEKVILSKLTVLTEQVWDPLSSS--------------QTARLVGFIHRL MKGYPTVLHGDNRY-----TQELLKTIVFRTRRTLEEDVFLPLYPKNVLENKNSSPYLFY QRQFWSCVKLFGNILQWEGILSSSCLRDLALDSTLNRYILSALQTTDTGEDNVQKCQKVA ECLPVQWFSGLKGQQTLPQLEPFCRYLTHLANSLHRGSVGGSDVERRTAKEQIKEVVKML GHMNALDHIIAVAAEH----------------G------------IKDIKPLLEAK-S >ENSLCRP00005061600 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------MF----- ------------------------------------------------------------ --------------------KKAKRANFRRRNESDEDEPEEGRQQQQQ------------ ------------------------------------------------------------ -----------------QQQ--------------------PP------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------LLAP--------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------TSFG--------------------------------------------- ----------P------------------------------VVEEI-------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------P-------------------------------------------- -----------------------FME---------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------------------TSSYS VTGAPMSTDSYH---------------------------------------------SNG FQANVNSMRAVKKEKKVKD----------------------------------------- --------------------------------VAPVCAPTKAS----------------- ------------------LLSF-DDD--E-EG---------------------------- ---------------------------------------------------------S-- ------EVFRVKKSNHSKKIVKQLKKEYKE------------------------------ ----------------------DLEKSG-------------------------------- ---HVKQEIKS------------------------------------DAPPQPAFAIKEE VT------------------------------------STAG------------------ --------------------------------------------SEQGEEEMEVDS---- TDEQEEEAR--------------------------------------------------- ----------SHG----GQAH---------------------------------GQVSKS NNSGATFNTLSSLGSLRP-----------GEIPDAAFIHAARKRRQLARELGGEAPLVET E-TPKKRLIG-ED---QDA-SD-DEDEEEKRIRFSGVKNKSQRQKIAEE--I---GIEGS DDEALD-T-GQDEEVSRWEQEQIRKGISIPQVQSNQPEDN-TVYYQNSYESQPYGSSYSM PFTY--STVTPQTSKPAGRADNGSVHYG-A---------------------------PIS DLTPVSIDLVKKRLQD-R------------------------------------------ ----------------------LGQMHASHNANAKRYKQIEEDLAASESTIQQLEGSSND NADQYKFLQEMRGYVGDLLECFSEKVPAVLELEAAMHQLLRQRASRLVQRRQDDIKDESS EFASLS-------------------NKAVMAPNLDSFGRDRAAYQEHSRQRRIAERE--- ---ARR-TRR-RQAREQNGKRAEHNEGLSSDDEETSTDITSFNMER--DRIIRECKKVFE DVVEDFHSLDCIKSHFEVWRREYADCYRDAYIGLCLPRLFNPLVRLQLITWNPLQ----- -------------------------------GQCENFEYMLWFESLLFYGFEEHST-LQK GDGDISLLPAIVEKVILSKLTVLAEQVWDPLSSS--------------QTASLVGFIHRL MKGYPTVLHGDNRY-----TQELLKMIVLRTRRTLDEDVFLPLYPKIVLENKNSGPYLFY QRQFWSCVKLLGNILQWEGILSNSCLRDLALDSTLNRYILSALQTTDTGEDNIPKCHKVV ECIPVHWFSGLKGQQTLPQLEPFCRYLTHLANSLHRSSFGAPDVERRTAKDQIKEVVRML GHMNALDHIITVAAEL----------------G------------IKDIKPLLEAK-S >ENSAPEP00000031883 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------MF----- ------------------------------------------------------------ --------------------KKAKRANFRRRNESDEDE-------QEE------------ ------------------------------------------------------------ -----------------SQQ--------------------HP------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------PLAP--------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------TSFG--------------------------------------------- ----------P------------------------------VV-EI-------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------P-------------------------------------------- -----------------------FME---------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------------------TSNNN VAAAPSCTDTYH---------------------------------------------SNG FQA--NIMRAIKKEKKTRE----------------------------------------- --------------------------------VAILPVPTKAS----------------- ------------------LLSF-DDD--E-EG---------------------------- ---------------------------------------------------------S-- ------EVFRVKKSNHSKKIVKQLKKEYKE------------------------------ ----------------------DLERSG-------------------------------- ---CVKQEVKS------------------------------------DGPPQPAVTIKED VT------------------------------------SRAG------------------ --------------------------------------------SEQGEEEMEVDS---- ADEHEEEAR--------------------------------------------------- ----------SQG----GQTQ---------------------------------SQASRS NNTGASFNTLSTLGSLRP-----------GEIPDAAFIHAARKRRQLARELGGETPLVET E-TPKKRLVR-ED---QDA-SD-DEDEEEKRIRFSGVRNKSQRQKIAEE--I---GIEGS DDEALD-A-GQDEEVSRWEQEQIRKGISIPQVQSSQPEDN-TVYYQNSYESQPYGASYSI PFTY--STVAPQIGKPTGRADNGSVHYG-A---------------------------VIS DLTPVSIDLVKKRLQD-R------------------------------------------ ----------------------LNQMHAGHNANTRRYKQIKEELAASESTIQQLEGSSND NADQYKFLQEMRGYVGDLLECFSEKVPAVLELEAAMHQLLRQRASRLVQRRQDDIKDESS EFASLS-------------------NKAVMAPNLDSFGRDRAAYQEHSRQRRIAERE--- ---ARR-TRR-RQAREQNGKRAEHNEGLSSDDEETSTDITSFNMER--DRIIRECKKVFE DVVEDFHSLDCIKSHFEVWRREYADCYRDAYIGLCLPKLFNPLVRLQLIAWNPLE----- -------------------------------AQCANFEYMLWFESLLFYGFEEHST-LQK GDGDIGLLPAIVEKVILSKLTVLAEQVWDPLSSS--------------QTARLVGFIHRL MKGYPTVLHGDNQY-----TQELLKTIVLRTRRTLDEDVFLPLYPKNILENKNSGPYLFY QRQFWSCVKLLGNILQWECILSSSCLRDLALDSTVNRYILSALQTTDTAEENVQKCQKVV ECLPTHWFSGLKGQQTLPQLEPLCRYLTHLANSMHRSSLGGSDIERRTSKEQIKEVVKML GQMNALDHIIAVAAEH----------------G------------IKDIKPLLEAK-S >ENSAOCP00000012533 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------MF----- ------------------------------------------------------------ --------------------KKAKRANFRRRNESDEDE-------QEE------------ ------------------------------------------------------------ -----------------SQQ--------------------HP------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------PLAP--------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------TSFG--------------------------------------------- ----------P------------------------------VV-EI-------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------P-------------------------------------------- -----------------------FME---------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------------------TSNNN VAAAPSCTDTYH---------------------------------------------SNG FQA--NIMRAIKKEKKTRE----------------------------------------- --------------------------------VAILPVPTKAS----------------- ------------------LLSF-DDD--E-EG---------------------------- ---------------------------------------------------------S-- ------EVFRVKKSNHSKKIVKQLKKEYKE------------------------------ ----------------------DLERSG-------------------------------- ---CVKQEVKS------------------------------------DGPPQPAVTIKED VT------------------------------------SRAG------------------ --------------------------------------------SEQGEEEMEVDS---- ADEHEEEAR--------------------------------------------------- ----------SQG----GQTQ---------------------------------SQASRS NNTGASFNTLSTLGSLRP-----------GEIPDAAFIHAARKRRQLARELGGETPLVET E-TPKKRLVR-ED---QDA-SD-DEDEEEKRIRFSGVRNKSQRQKIAEE--I---GIEGS DDEALD-A-GQDEEVSRWEQEQIRKGISIPQVQSSQPEDN-TVYYQNSYESQPYGASYSI PFTY--STVAPQIGKPAGRADNGSVHYG-A---------------------------VIS DLTPVSIDLVKKRLQD-R------------------------------------------ ----------------------LNQMHAGHNANTRRYKQIKEELAASESTIQQLEGSSND NADQYKFLQEMRGYVGDLLECFSEKVPAVLELEAAMHQLLRQRASRLVQRRQDDIKDESS EFASLS-------------------NKAVMAPNLDSFGRDRAAYQEHSRQRRIAERE--- ---ARR-TRR-RQAREQNGKRAEHNEGLSSDDEETSTDITSFNMER--DRIIRECKKVFE DVVEDFHSLDCIKSHFEVWRREYADCYRDAYIGLCLPKLFNPLVRLQLIAWNPLE----- -------------------------------AQCANFEYMLWFESLLFYGFEEHST-LQK GDGDIGLLPAIVEKVILSKLTVLAEQVWDPLSSS--------------QTARLVGFIHRL MKGYPTVLHGDNQY-----TQELLKTIVLRTRRTLDEDVFLPLYPKNILENKNSGPYLFY QRQFWSCVKLLGNILQWECILSSSCLRDLALDSTVNRYILSALQTTDTAEENVQKCQKVV ECLPTHWFSGLKGQQTLPQLEPFCRYLTHLANSMHRSSLGGSDIERRTSKEQIKEVVKML GQMNALDHIIAVAAEH----------------G------------IKDIKPLLEAK-S >ENSSPAP00000005030 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------MF----- ------------------------------------------------------------ --------------------KKAKRVNLRRRNESDEEE-------QEE------------ ------------------------------------------------------------ -----------------SQQ--------------------HP------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------LLAP--------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------TSFG--------------------------------------------- ----------P------------------------------VV-EI-------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------P-------------------------------------------- -----------------------FME---------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------------------TSNNN VTGAPSSTDNYH---------------------------------------------SNG FQA--NSVRAVKKEKKTKE----------------------------------------- --------------------------------TIPLPVPTKAS----------------- ------------------LLSF-DDE--E-EG---------------------------- ---------------------------------------------------------S-- ------EVFRVKKSNHSKKIVKQLKKEYKE------------------------------ ----------------------DLERSG-------------------------------- ---YVKQEVKS------------------------------------DGPPQPAVTIKEE VT------------------------------------SRAG------------------ --------------------------------------------SEQGEEEMEVDS---- ADEHEEEAK--------------------------------------------------- ----------SQG----GQAQ---------------------------------SQASRS NNTGASFNTLSSLGSLRP-----------GEIPDAAFIHAARKRRQLARELGGETPLVET E-TPKKRLVR-ED---QDV-SD-DEDEEEKRIRFSGVRNKSQRQKIAEE--I---GIEGS DDEALE-P-GQDEEVSRWEQEQIRKGISIPQVQSSQPEDT-TVYYQNSYESQPYGASYSI PFTY--STVTPQAGKPTGRADNGSVHFG-A---------------------------LVS DLTPVSIDLVKKRLQD-R------------------------------------------ ----------------------LNHMHAGHNANAKRYKQIKDELAASESTIQQLEGSSND NADQYKFLQEMRGYVGDLLECFSEKVPAVLELEAAMHQLLRQRASRLVQRRQDDIKDESS EFASLS-------------------NKAVMAPNLDSFGRDRAAYQEHSRQRRIAERE--- ---ARR-TRR-RQAREQNGKRAEHNEGFSSDDEETSTDITSFNMEK--DRIIKECKKVFE DVVEDFHSLDCIKSHFEVWRREYADCYRDAYIGLCLPKLFNPLVRLQLIAWNPVE----- -------------------------------TQCANFEYMLWFESLLFYGFEEHST-LQK GDGDIGLLPAIVEKVILSKLTVLAEQVWDPLSSS--------------QTARLVGFIHRL MKGYPTVLHGDNQY-----TQELLKTIVLRTRRTLDEDVFLPLYPKNVLENKNSGPYLFY QRQFWSCVKLLGNILQWESVLSSSCLRDLALDSTLNRYILSALQTTDTAEENVQKCQKVA ECLPAHWFSGLKGQQTLPQLEPFCRYLTHLANSMHRSSLGGSDVERRTSKEQIKEVVKML GQMNALNHIIAVAAEH----------------G------------IKDIKPLLEAK-S >ENSSMAP00000014661 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------MF----- ------------------------------------------------------------ --------------------KKAKRANFRRRNESDEDE-------PEA------------ ------------------------------------------------------------ -----------------SQR--------------------PP------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------LAP--------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------TSCG--------------------------------------------- ----------P------------------------------VVEEI-------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------P-------------------------------------------- -----------------------FMENLTS------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------AFTRA------------------------------ ----------------PGASDNFNSNGFLANLSGXXXXXXGRAAKKETKVKEAIA----- ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------VPGPTKAS----------------- ------------------LLSF-HDD--E-EG---------------------------- ---------------------------------------------------------S-- ------EVFRVKKPNHSKKIVKQLKKEYKE------------------------------ ----------------------DLEKSG-------------------------------- ---SVKQESKS------------------------------------DVSLQLPVSIKEE VT------------------------------------SQAC------------------ --------------------------------------------SEQGEEEMEVDS---- AEEHDEEARVQT--------------------------------------AKSNS----- --------SC-------------------------------------------------- ----ATFNTLSSLGSLRP-----------GEIPDAAFIHAARKRRQLARELGGETPLVET E-APKKRLVG-ED---QDA-SD-DEDEEEKRIRFSGVKNKSQRQKIAEE--I---GIEGS DDEALD-T-GQDEEVSRWEQEQIRKGISIPQVQSSQPEDN-TVYYQNSYESQPYGSSYSM PFTY--STVAPQTSKPTGRANNGSVHYG-A---------------------------PVS DLTPVSIDLVKKRLQD-R------------------------------------------ ----------------------LGQMSVGHNANSRRYKEIEDDLAASESTIRQLEGSSNV NAEQYKFLQEMRGYVGDLLECFSEKVPAVLELEAAMHQLLRQRAARLVQRRQDDIKDESA EFASLS-------------------NKAVMAPNLDSFGRDRAAYQEHSRQRRIAERE--- ---ARR-TRR-RQAREQNGKRAEHKEGLSSDDEETSTDITSFNMEK--DRINRDCKKVFE DVVEDFHSLDFIKSHFEVWRRNYADCYRDAYIGLCLPKLFNPLVRLQLITWNPLE----- -------------------------------APCANFEYMLWFESLLFYGFEEHGT-LQR GDGDISLLPAIVEKVILSKLTVLTEQVWDPLSSS--------------QTARLVGFVRRL MKGYPTVLHGENRY-----TEELLKSIVLRTRRTLDEDVFLPLYPKNVLENKNSGPYLFY QRQFWSCVKLLGNILQWEGILSTSCLKDLALDSTLNRYILSALQTTDTAEDNVQKCQKVV ECLPVHWFSGLKGQQTLPQLEPFCRYLTHLANSLQRSTVGGSDVERRTAKEQVKESVKML GHMNALDHILTVAAEH----------------G------------IKDIKPLLEAM-S >ENSMZEP00005025913 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------MF----- ------------------------------------------------------------ --------------------KKAKRANFRRRNESDEDE-------QEE------------ ------------------------------------------------------------ -----------------SQQ--------------------PQ------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------LAP--------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------TMFG--------------------------------------------- ----------P------------------------------T--EI-------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------P-------------------------------------------- -----------------------FME---------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------------------TSNSN ATGVLSTTESCH---------------------------------------------SNG LQA--NSVRAVKKEKKVKD----------------------------------------- --------------------------------TTAVPGPTKAS----------------- ------------------LLSF-VDE--E-DG---------------------------- ---------------------------------------------------------S-- ------EVFRVKKSNHSKKILKQLKKEYKE------------------------------ ----------------------DLERSG-------------------------------- ---STKQDVKS------------------------------------DAPAQP--AVKEE VI------------------------------------SRAS------------------ --------------------------------------------SEQGEEEMEVES---- ADEQEEDAR--------------------------------------------------- ----------SQS----GQTN---------------------------------SQVSRS NSTGATFNTLSTLGSLRP-----------GEIPDAAFIHAARKRRQLARELGGDAPLVET E-APKKRLVR-ED---QDA-SD-DEDEEEKRIRFSGVRNKSQRQKIAEE--I---GIEGS DDEALD-T-GQDEEVSRWEQEQIRKGISIPQVQSSQPEDS-TVYYQNSYESQPYGSSYSM PYTY--STVAPQTAKQTGQADNGSVHYG-A---------------------------SLN DLIPVSIDLVKKRLQD-R------------------------------------------ ----------------------LSQMHAGHNGNVDRYKQINEDLAASERTIQQLEDSSND NAEQYKFLQEMRGYVGDLLECFSEKVPAVLELEAAMHQLLRQRATRLVQRRQDDIKDESS EFASLS-------------------NKAVMAPNLDSFGRDRAAYQEHSRQRRIAERE--- ---ARR-TRR-RQAREQNGKRAEHKEGLSSDDEETSTDITSFNMER--DRIIRESKKVFE DVVEDFHSLDYIKSHFEVWRKEYANTYRDAYIGLCLPKLFNPLVRLQLITWNPLE----- -------------------------------AQCANFEYMLWFESLLFYGFEENST-LQK GDGDIGLLPAIVEKVILSKLSVLAEQVWDPLSSS--------------QTTRFVSFIHRL LKGYPTVLHGDNRY-----TQELLKTIVLRTRRTLDEDVFLPLYPKNILENKNSGPYLFY QRQFWSCVKLLGNILQWDGILSMSSLKDLALDSTLNRYILSALQTTDTWEENIQKCQKVV ECLPSHWFSGLKGQQTLPQLEPFCRYLTHLANSIHRSALVGSDIERRTSKEQVKDVVKML GQMNALDHIIAVAAEH----------------G------------IKDIKPLLEVK-S >ENSACLP00000034019 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------MF----- ------------------------------------------------------------ --------------------KKAKRANFRRRNESDEDE-------QEE------------ ------------------------------------------------------------ -----------------SQQ--------------------PQ------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------LAP--------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------TMFG--------------------------------------------- ----------P------------------------------T--EI-------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------P-------------------------------------------- -----------------------FME---------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------------------TSNSN ATGVLSTTESCH---------------------------------------------SNG LQA--NSVRAVKKEKKVKD----------------------------------------- --------------------------------TTAVPGPTKAS----------------- ------------------LLSF-VDE--E-DG---------------------------- ---------------------------------------------------------S-- ------EVFRVKKSNHSKKILKQLKKEYKE------------------------------ ----------------------DLERSG-------------------------------- ---STKQDVKS------------------------------------DAPAQP--AVKEE VI------------------------------------SRAS------------------ --------------------------------------------SEQGEEEMEVES---- ADEQEEDAR--------------------------------------------------- ----------SQS----GQTN---------------------------------SQVSRS NSTGATFNTLSTLGSLRP-----------GEIPDAAFIHAARKRRQLARELGGDAPLVET E-APKKRLVR-ED---QDA-SD-DEDEEEKRIRFSGVRNKSQRQKIAEE--I---GIEGS DDEALD-T-GQDEEVSRWEQEQIRKGISIPQVQSSQPEDS-TVYYQNSYESQPYGSSYSM PYTY--STVAPQTAKQTGQADNGSVHYG-A---------------------------SLN DLIPVSIDLVKKRLQD-R------------------------------------------ ----------------------LSQMHAGHNGNVDRYKQINEDLAASERTIQQLEDSSND NAEQYKFLQEMRGYVGDLLECFSEKVPAVLELEAAMHQLLRQRATRLVQRRQDDIKDESS EFASLS-------------------NKAVMAPNLDSFGRDRAAYQEHSRQRRIAERE--- ---ARR-TRR-RQAREQNGKRAEHKEGLSSDDEETSTDITSFNMER--DRIIRESKKVFE DVVEDFHSLDYIKSHFEVWRKEYANTYRDAYIGLCLPKLFNPLVRLQLITWNPLE----- -------------------------------AQCANFEYMLWFESLLFYGFEENST-LQK GDGDIGLLPAIVEKVILSKLSVLAEQVWDPLSSS--------------QTTRFVSFIHRL LKGYPTVLHGDNRY-----TQELLKTIVLRTRRTLDEDVFLPLYPKNILENKNSGPYLFY QRQFWSCVKLLGNILQWDGILSMSSLKDLALDSTLNRYILSALQTTDTWEENIQKCQKVV ECLPSHWFSGLKGQQTLPQLEPFCRYLTHLANSIHRSALVGSDIERRTSKEQVKDVVKML GQMNALDHIIAVAAEH----------------G------------IKDIKPLLEVK-S >ENSNBRP00000012311 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------MF----- ------------------------------------------------------------ --------------------KKAKRANFRRRNESDEDE-------QEE------------ ------------------------------------------------------------ -----------------SQQ--------------------PQ------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------LAP--------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------TMFG--------------------------------------------- ----------P------------------------------T--EI-------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------P-------------------------------------------- -----------------------FME---------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------------------TSNSN ATGVLSTTESCH---------------------------------------------SNG LQA--NSVRAVKKEKKVKD----------------------------------------- --------------------------------TTAVPGPTKAS----------------- ------------------LLSF-VDE--E-DG---------------------------- ---------------------------------------------------------S-- ------EVFRVKKSNHSKKIVKQLKKEYKE------------------------------ ----------------------DLERSG-------------------------------- ---STKQD--------------------------------------------P--AVKEE VI------------------------------------SRAS------------------ --------------------------------------------SEQGEEEMEVES---- ADEQEEDAR--------------------------------------------------- ----------SQS----GQTNNE-------DF---SDF---------------I------ -----------------P-----------GEIPDAAFIHAARKRRQLARELGGDAPLVET E-TPKKRLVR-ED---QDA-SD-DEDEEEKRIRFSGVRNKSQRQKIAEE--I---GIEGS DDEALD-T-GQDEEVSRWEQEQIRKGISIPQVQSSQPEDS-TVYYQNSYESQPYGSSYSM PYTY--STVAPQTAKPTGQTDNGSVHYG-A---------------------------PLN DLIPVSIDLVKKRLQD-R------------------------------------------ ----------------------LSQMHAGHNGNVDRYKQINEDLAASERTIQQLEDSSND NAEQYKFLQEMRGYVGDLLECFSEKVPAVLELEAAMHQLLRQRATRLVQRRQDDIKDESS EFASLS-------------------NKAVMAPNLDSFGRDRAAYQEHSRQRRIAERE--- ---ARR-TRR-RQAREQNGKRAEHKEGLSSDDEETSTDITSFNMER--DRIIRESKKVFE DVVEDFHSLDYIKSHFEVWRKEYANTYRDAYIGLCLPKLFNPLVRLQLITWNPLE----- -------------------------------AQCANFEYMLWFESLLFYGFEENST-LQK GDGDIGLLPAIVEKVILSKLSVLAEQVWDPLSSS--------------QTTRFVSFIHRL LKGYPTVLHGDNRY-----TQELLKTIVLRTRRTLDEDVFLPLYPKNILENKNSGPYLFY QRQFWSCVKLLGNILQWDGILSTSSLKDLALDSTLNRYILSALQTTDTWEENIQKCQKVV ECLPSHWFSGLKGQQTLPQLEPFCRYLTHLANSIHRSALVGSDIERRTSKEQVKDVVKML GQMNALDHIIAVAAEH----------------G------------IKDIKPLLEVK-S >ENSHBUP00000026725 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------MF----- ------------------------------------------------------------ --------------------KKAKRANFRRRNESDEDE-------QEE------------ ------------------------------------------------------------ -----------------SQQ--------------------PQ------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------LAP--------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------TMFG--------------------------------------------- ----------P------------------------------T--EI-------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------P-------------------------------------------- -----------------------FME---------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------------------TSNSN ATGVLSTTESCH---------------------------------------------SNG LQA--NSVRAVKKEKKVKD----------------------------------------- --------------------------------TTAVPGPTKAS----------------- ------------------LLSF-VDE--E-DG---------------------------- ---------------------------------------------------------S-- ------EVFRVKKSNHSKKILKQLKKEYKE------------------------------ ----------------------DLERSG-------------------------------- ---STKQD--------------------------------------------P--AVKEE VI------------------------------------SRAS------------------ --------------------------------------------SEQGEEEMEVES---- ADEQEEDAR--------------------------------------------------- ----------SQS----GQTNNE-------DF---SDF---------------I------ -----------------P-----------GEIPDAAFIHAARKRRQLARELGGDAPLVET E-APKKRLVR-ED---QDA-SD-DEDEEEKRIRFSGVRNKSQRQKIAEE--I---GIEGS DDEALD-T-GQDEEVSRWEQEQIRKGISIPQVQSSQPEDS-TVYYQNSYESQPYGSSYSM PYTY--STVAPQTAKPTGQADNGSVHYG-A---------------------------SLN DLIPVSIDLVKKRLQD-R------------------------------------------ ----------------------LSQMHAGHNGNVDRYKQINEDLAASERTIQQLEDSSND NAEQYKFLQEMRGYVGDLLECFSEKVPAVLELEAAMHQLLRQRATRLVQRRQDDIKDESS EFASLS-------------------NKAVMAPNLDSFGRDRAAYQEHSRQRRIAERE--- ---ARR-TRR-RQAREQNGKRAEHKEGLSSDDEETSTDITSFNMER--DRIIRESKKVFE DVVEDFHSLDYIKSHFEVWRKEYANTYRDAYIGLCLPKLFNPLVRLQLITWNPLE----- -------------------------------AQCANFEYMLWFESLLFYGFEENST-LQK GDGDIGLLPAIVEKVILSKLSVLAEQVWDPLSSS--------------QTTRFVSFIHRL LKGYPTVLHGDNRY-----TQELLKTIVLRTRRTLDEDVFLPLYPKNILENKNSGPYLFY QRQFWSCVKLLGNILQWDGILSMSSLKDLALDSTLNRYILSALQTTDTWEENIQKCQKVV ECLPSHWFSGLKGQQTLPQLEPFCRYLTHLANSIHRSALVGSDIERRTSKEQVKDVVKML GQMNALDHIIAVAAEH----------------G------------IKDIKPLLEVK-S >ENSPNYP00000001753 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------MF----- ------------------------------------------------------------ --------------------KKAKRANFRRRNESDEDE-------QEE------------ ------------------------------------------------------------ -----------------SQQ--------------------PQ------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------LAP--------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------TMFG--------------------------------------------- ----------P------------------------------T--EI-------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------P-------------------------------------------- -----------------------FME---------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------------------TSNSN ATGVLSTTESCH---------------------------------------------SNG LQA--NSVRAVKKEKKVKD----------------------------------------- --------------------------------TTAVPGPTKAS----------------- ------------------LLSF-VDE--E-DG---------------------------- ---------------------------------------------------------S-- ------EVFRVKKSNHSKKILKQLKKEYKE------------------------------ ----------------------DLERSG-------------------------------- ---STKQD--------------------------------------------P--AVKEE VI------------------------------------SRAS------------------ --------------------------------------------SEQGEEEMEVES---- ADEQEEDAR--------------------------------------------------- ----------SQS----GQTNNE-------DF---SDF---------------I------ -----------------P-----------GEIPDAAFIHAARKRRQLARELGGDAPLVET E-APKKRLVR-ED---QDA-SD-DEDEEEKRIRFSGVRNKSQRQKIAEE--I---GIEGS DDEALD-T-GQDEEVSRWEQEQIRKGISIPQVQSSQPEDS-TVYYQNSYESQPYGSSYSM PYTY--STVAPQTAKPTGQADNGSVHYG-A---------------------------SLN DLIPVSIDLVKKRLQD-R------------------------------------------ ----------------------LSQMHAGHNGNVDRYKQINEDLAASERTIQQLEDSSND NAEQYKFLQEMRGYVGDLLECFSEKVPAVLELEAAMHQLLRQRATRLVQRRQDDIKDESS EFASLS-------------------NKAVMAPNLDSFGRDRAAYQEHSRQRRIAERE--- ---ARR-TRR-RQAREQNGKRAEHKEGLSSDDEETSTDITSFNMER--DRIIRESKKVFE DVVEDFHSLDYIKSHFEVWRKEYANTYRDAYIGLCLPKLFNPLVRLQLITWNPLE----- -------------------------------AQCANFEYMLWFESLLFYGFEENST-LQK GDGDIGLLPAIVEKVILSKLSVLAEQVWDPLSSS--------------QTTRFVSFIHRL LKGYPTVLHGDNRY-----TQELLKTIVLRTRRTLDEDVFLPLYPKNILENKNSGPYLFY QRQFWSCVKLLGNILQWDGILSMSSLKDLALDSTLNRYILSALQTTDTWEENIQKCQKVV ECLPSHWFSGLKGQQTLPQLEPFCRYLTHLANSIHRSALVGSDIERRTSKEQVKDVVKML GQMNALDHIIAVAAEH----------------G------------IKDIKPLLEVK-S >ENSONIP00000006026 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------MF----- ------------------------------------------------------------ --------------------KKAKRANFRRRNESDEDE-------QEE------------ ------------------------------------------------------------ -----------------SQQ--------------------PQ------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------LAP--------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------TMFG--------------------------------------------- ----------P------------------------------T--EI-------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------P-------------------------------------------- -----------------------FME---------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------------------TSNSN ATGAPSTTESCH---------------------------------------------SNG LQG--NTVRAVKKEKKVKD----------------------------------------- --------------------------------TTAVPGPTKAS----------------- ------------------LLSF-VDE--EADS---------------------------- ---------------------------------------------------------S-- ------EVFRVKKSNHSKKIVKQLKKEYKE------------------------------ ----------------------DLERSG-------------------------------- ---STKQDVKSA------------PN----------------YEFFLDAPTQL--AVKEE VI------------------------------------SRAS------------------ --------------------------------------------SEQGEEEMEVES---- ADEQEE------------------------------------------------------ -----------------------------------------------------------S NSTGATFNTLSTLGSLRP-----------GEIPDAAFIHAARKRRQLARELGGDAPLVET E-APKKRLVR-ED---QDA-SD-DEDEEEKRIRFSGVRNKSQRQKIAEE--I---GIEGS DDEALD-T-GQDEEVSRWEQEQIRKGISIPQVQSSQPEDS-TVYYQNSYESQPYGSSYSM PYTY--STVAPQTAKPSGQADNGSVHYG-A---------------------------PLN DLIPVSIDLVKKRLQD-R------------------------------------------ ----------------------VSQMRAGHNANVDRYKQINEDLAASERTIQQLEGSSND NAEQYKFLQEMRGYVGDLLECFSEKVPAVLELEAAMHQLLRQRATRLVQRRQDDIKDESS EFASLS-------------------NKAVMAPNLDSFGRDRAAYQEHSRQRRIAERE--- ---ARR-TRR-RQAREQNGKRAEHKEGLSSDDEETSTDITSFNMER--DRIIRESKKVFE DVVEDFHSLDYIKSHFEVWRKEFANTYRDAYIGLCLPKLFNPLVRLQLITWNPLE----- -------------------------------AQCANFEYMLWFESLLFYGFEENST-LQK GDGDIGLLPAIVEKVILSKLSVLAEQVWDPLSSS--------------QTTRFVSFIHRL LKGYPTVLHGDNRY-----TQELLKTIVLRTRRTLDDDVFLPLYPKNILENKNSGPYLFY QRQFWSCVKLLGNILQWDGILSMSSLKDLALDSTLNRYILSALQTTDTWEENIQKCQKVV ECLPSHWFSGLKGQQTLPQLEPFCRYLTHLANSIHRNTLVGSDIERRTSKEQVKDVVKML GQMNALDHIIAVAAEH----------------G------------IKDIKPLLEVK-- >ENSLBEP00000016287 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------MF----- ------------------------------------------------------------ --------------------KKAKRANFRRRNESDEDE-------LED------------ ------------------------------------------------------------ -----------------PRQ--------------------PQ------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------LAP--------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------TLFG--------------------------------------------- ----------P------------------------------VGGEI-------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------P-------------------------------------------- -----------------------FME---------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------SSNNGAAGAPGGTENVHSNGFLANVNVLRAV KKEKKSKEAVN----IP------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------APGPTKAS----------------- ------------------LLSF-VDD--E-EG---------------------------- ---------------------------------------------------------S-- ------DVFRVKKSTHSKKIVKQLKKEYKE------------------------------ ----------------------DLEKSG-------------------------------- ---SVKQDNKS------------------------------------DAPLHPLISIKEE VT------------------------------------SRAG------------------ --------------------------------------------SEHGEEEMEVDS---- ADEQEEEAR--------------------------------------------------- ----------SQG----GQAQ---------------------------------GQVTKS NSAATSFNTLSSLGSLKP-----------GEIPDAAFIHAARKRRQLARELGGDAPLVET E-TPKKRLGG-ED---QDA-SE-DEDDEEKRIRFSGVKNKSQRQKIAEE--I---GIEGS DDEALD-T-GQDEEVSRWEQEQIRKGISIPQVQSSQPEDN-TVYYQNSYESQPYGASYSM PFTY--STMAPQTCKATGRADNGSVHYG-V---------------------------PFS DLTPVSIDLVKKRLQD-R------------------------------------------ ----------------------LSQMHAGHNANAKRFRQIEEDLAASESSIQHLEGSAND NAEQYKFLQEMRGYVGDLLECFSEKVPAILELEAAMHQLLRQRASRLVQRRQDDIKDESS EFASLS-------------------SKAVMAPSLDSFGRDRTAYQEHSRQRRIAERE--- ---ARR-TRR-RQAREQNGKRAEHKEGLSSDDEETSTDVTSFNIER--DRISRECKKAFE DVVEDFHSLDCIKSHFEVWRRDYADCYRDAYIGLCLPKLFNPLVRLQLITWNPLG----- -------------------------------ANCANFEYMLWFESLLFYGFEEHST-LQS GDGDISLLPAIVEKVILSKLTVLAEQVWDPLSSS--------------QTASLVGFIHRL MKGYPTVLHGDNRY-----TQELLKTVVLRARRTLDEDVFLPLYPKNVLENKNSGPYLFY QRQFWSCVKLLGNILQWDGILSTSCLRDLALDSTLNRYILSALQTTDLCEDNVLKCQKVV ECLPLHWFSGLKGQQTLPQLEPFCRYVTHLANSLHRSTLGVSDVERRTVKDQTKELVKML GHMNALDHIVTVAAEH----------------G------------VKDIKQLLEAK-S >ENSPRNP00000035267 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------MF----- ------------------------------------------------------------ --------------------KKAKRANFRRRNESDEEE-------HDE------------ ------------------------------------------------------------ -----------------SQQ--------------------QS------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------LAP--------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------TSFG--------------------------------------------- ----------P------------------------------VGVEI-------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------P-------------------------------------------- -----------------------FMET--------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------------------NNT TTAAPSSTDNCH---------------------------------------------RNG FLANINSVRAVKKEKKGKE----------------------------------------- --------------------------------AAPLPTPTKPS----------------- ------------------LLSF-DDE--E-EG---------------------------- ---------------------------------------------------------S-- ------EVFRVKKSNHSKKIVKQLKKEYKE------------------------------ ----------------------DLEKSG-------------------------------- ---CVKQESRS------------------------------------DAPHQPQVAIKEE VT------------------------------------SRAG------------------ --------------------------------------------SEQGEEEMEVDS---- ADEQEEDSR--------------------------------------------------- ----------NQG----AQAQ---------------------------------SQVSR- NNTGPSFNTLSSLGSLRP-----------GEIPDAAFIHAARKRRQMARELGGDAPLTVT E-APKQRLVR-ED---QDA-SD-DED-EEKRIRFSGVRNKSQRQKIAEE--I---GIEGS DDEALD-T-GQDEEVSRWEQEQIRKGISIPQVQSSQPEEN-TVYYQNSYESQPYGSTYSM PFTY--STVAPQTGKPTGHADNGSVHYG-A---------------------------PLS DLSPVSIDLVKKRLQD-R------------------------------------------ ----------------------LSQMHAGHDANTRRYKQIKEDLAASESTIQQLEGSSND NADQYKFLQEMRGYVGDLLECFSEKVPAVLELEAAMHQLLRQRASRLVQRRQDDIKDESS EFASLS-------------------NKAVMAPSLDSFGRDRTAYLEHSRQRRIAERE--- ---ARR-TRR-RQAREQNGKRAEHNEGMSSDDEETSTDITSFDMEK--DRIIRECKKVFE DVVEDFHSLDCIKSHFEVWRHEYADCYRDAYIGLCLPKLFNPLVRLQLISWNPLD----- -------------------------------AQCANFEYMLWFESLLFYGFEENTI-LQR GDGDIGLLPAIVERVIVSKLTVLAEQVWDPLSDS--------------QTARLVSFIQRL MKSYPTVLHGDNRY-----TQELLKTIVLRTRRTLDEDVFLPLYPRSVLENKNSSPYLFY QRQFWSCIKLLGNILQWEGILSTSCLKDLALDSTLNRYILSALQTTDTEEDNVQKCQKVV ECLPAHWFSGLKGQQTLPQLEPFCRYLVYVANSLHRSSLGRSDVERRTYKEQIREVVKML GHMNALDHIIAVAEEH----------------G------------IKDIKPLLEVK-S >ENSMALP00000012092 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------MF----- ------------------------------------------------------------ --------------------KKAKRVNLRRRNESDEEE-------LDE------------ ------------------------------------------------------------ -----------------TQQ--------------------PP------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------LAP--------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------TLLG--------------------------------------------- ----------P------------------------------VVEQI-------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------P-------------------------------------------- -----------------------FIE---------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------------------TCNNS ITGAPSSTDNCP---------------------------------------------SNG LQPSFNSVRAVKKEKRGKD----------------------------------------- --------------------------------TPAVPGPTKVS----------------- ------------------LLSF-DDE--E-EG---------------------------- ---------------------------------------------------------S-- ------EVFRVKKSNHSKKIVKQLKKEYKE------------------------------ ----------------------DLERSG-------------------------------- ---YVKQEIRS------------------------------------DAPPQPAVAIKEE VT------------------------------------SRAG------------------ --------------------------------------------SEHGEEEMEVDS---- ADEPEEDTR--------------------------------------------------- ----------SLG----VQAP---------------------------------SQMSKS NNTGATFNTLSSLGSLRP-----------GEIPDAAFIHAARKRRQMARELGGEAPLVEK E-GLTKRLVQ-ED---QDV-SD-NEDEDEKRISFSGVQNKSQRQKIAEE--I---GIEGS DDEALD-T-GQDEEVSRWEQEQIRKGISIPQVQSSQPEGN-TVYYQNSYESQPYGSSYSM PFTY--SAVAPQACKPTIRADNGSVHYG-A---------------------------SIS DLTPVSIDLVKKRLQD-R------------------------------------------ ----------------------LSQMCAGHNANAKRHKQIEEDLAASESAIQQLEGSSND NADQYKFLQEMRGYVGDLLECFSEKVPAVLELEAAMHQLLRQRASRLVQRRQDDIKDESS EFASLS-------------------NKAVMAPNLDSFGRDRTAYQEHSRQRRIAERE--- ---ARR-TRR-RQAREQNGKRADHKEGLSSDDEETSTDITSFNMEK--DRIIRESKKVFE DVLEDFHSLDCIKARFEVWRKDYADCYREAYIGLCLPRLFNPLIRLHLITWNPLE----- -------------------------------AQCTNFEYMLWFESMLFYGFEEHSI-LQK GDGDIGLLPAIVEKVIISKLTVLAEQVWDPLSGS--------------QTTRLVGFIYRL MKGYPTVMHGDNRY-----TQELLKAVVLRTRRTLDEDVFLPLYPKNVLENKNSSPYLFY QRQFWSCVKLLGNILQWDGILSTSCLKDLALDSTLNRYILSALQTTDTAEDNVPKCQKVV ECLPVQWFSGLKGQQTLPHLEPFCRYLTHLASSLHRSSLGSADVERRSAKEQIKEIVKML HHMNALDHIIAVAEEH----------------G------------VKDIKTLLEAK-S >ENSBSLP00000022036 M----------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------------KTMF----- ------------------------------------------------------------ --------------------KKAKRVNLRRRNESDEDE-------LEE------------ ------------------------------------------------------------ -----------------GHQ--------------------QQQ----------------- ------------------------------------------------------------ --QHQ------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---P-------------------------------------------------------- ---------------------------------------QPLLAP--------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------TSFG--------------------------------------------- ----------P------------------------------VFEEI-------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------P-------------------------------------------- -----------------------FME---------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------------------TSSNS TSGAASDTDNCH---------------------------------------------SNG LLANLNNVRAVKKEKKGKE----------------------------------------- --------------------------------TASAPGAAKSI----------------- ------------------LLSF-DDE--E-EG---------------------------- ---------------------------------------------------------S-- ------EVFRVKKSNHSKKIVKQLKKEYKE------------------------------ ----------------------DLERTG-------------------------------- ---NVKQDSKP------------------------------------DAPMHPAISIKEE LT------------------------------------SRPG------------------ --------------------------------------------SERGEEEMEVES---- ADEQEEEGK--------------------------------------------------- ----------GQG----GQAH---------------------------------SQLSRS NNAGATFNTLSSLGSLKP-----------GEIPDAAFIHAARKRRQMARELGGETPLVET E-TQKKRLVR-ED---QDV-SD-DEDEEEKRIRFSGVKNKSQRQKIAEE--I---GIEGS DDEALD-T-GQDEEVSRWEQEQIRKGISIPQVQSTQPEDN-TMYYQNSYESQPYGSSYSM PFTY--STVVAQTGKPTGRADNGSVHYG-V---------------------------PVS APSPVSIDLVKKRLQD-R------------------------------------------ ----------------------LSQMHAGHNGNVKRYKQIEEDLAASESAIQQLEGSSND NADQYKFLQEMRGYVGDLLECFSEKVPAVLELEAAMHQLLRQRASRLVQRRQDDIKDESS EFASLS-------------------NKAVMAPNLDSFGRDRAAYQEHSRQRRIAERE--- ---ARR-TRR-RQAREQNGKRAEHKEGLSSDDEETSTDITSFNMEK--ERIARECKKVFE DVVEDFHSLDYIKSHFEVWRRDYADCYKDAYIALCLPKLLSPLVRLELITWNPLE----- -------------------------------AQCANFEYMLWFESLLFYGFEEHST-LEK GDGDIGLLPAIVEKVILSKLTVLAEQVWDPLSSS--------------QTARLIGFIHRL IKGYPTVLHGDNQY-----TQELLKSVVLRTRRTLDEDIFLPLYPKSVLENKNSSPYLFY QRQFWSCVKLLGNILQWDGVLSTSCLKDLALDSTLNRYILSALQTTDTEEDNVQKCQKVV ECLPSQWFSGLKGQQTLPQLEPLCRYLAHLANSLYRSSVGTSDMERRTAKEQVKDVVKML RHLNGLDHIITVAAAH----------------G------------VKDVKLFLEAK-S >ENSMMOP00000001074 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------MF----- ------------------------------------------------------------ --------------------KKAKRANFRRRNESDEEE-------Q-E------------ ------------------------------------------------------------ -----------------SQQ--------------------PL------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------LAS--------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------TLFG--------------------------------------------- ----------P------------------------------VVEEI-------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------P-------------------------------------------- -----------------------FME---------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------------------TSNNS VTGVCSTTENHH---------------------------------------------SNG FQANVNSLRAVKKEKKSKD----------------------------------------- --------------------------------ISMVPGPTKAS----------------- ------------------LLSF-DDD--E-DE---------------------------- ---------------------------------------------------------S-- ------EVFRVRKSNHSKKIVKQLKKEYKE------------------------------ ----------------------DLEKSG-------------------------------- ---CVKQETKTG------------AT----------------------------VAVKEE AI------------------------------------SRVG------------------ --------------------------------------------SDHGEEEMEVDS---- ADEQDEEGR--------------------------------------------------- ----------SQG----GQTH---------------------------------SQITKS -NTGATFNTLSSLGSLRP-----------GEIPDAAFIHAARKRRQLARELGGDAPLVET E-APKKRLVG-ED---QDA-SD-DEDDEEKRIRFSGVKSKSQRQKIAEE--I---GIEGS DDEALD-T-GHDEELSRWEQEQIRKGISIPQVQSSQSEDN-MVYYQNSYESQPYGSSYSV PFTY--STVAPQTGKPTSQADNGSIHYGTA---------------------------TFS DLTPVSIDLVKKRLQD-R------------------------------------------ ----------------------LSLMHTSNNANTKRYKQIEDDLAASESTIQHLEGSSND NAAQYKFLQEMRGYVGDLLECFSEKVPDVLELEAAMHQLLRQRASRLVQRRQDDIKDESS EFASLS-------------------SKAVMAPNLDSFGRDRAAYQEHSRQRRIAERE--- ---ARR-TRR-RQAREQNGKRAEHKEGLSSDDEETSTDITSFNMER--DRIIKECKKVFE DVVEDFHSLDCIKSHFEVWRREYADSYRDAYIGLCLPKLFNPLVRLQLITWNPLE----- -------------------------------GECANFEYMLWFESLLFYGFEENST-LQG GDGDVSLLPSIVEKVILSKLTVLAEQVWDPLSSS--------------QTASLVNFIHRL MKGYPTVLHGDNQY-----TQELLKTIVLRTRRTLDEDVFLPLYPKNVLENKNSGPYLFY QRQFWSCVKLLGNILQWENILSISCLRDLALDSTLNRYILSALQTADTGEENVLRCQKVV EYLPSQWFSGLKGQQTLPQLEPFCRYLAHLANSLYRSSVGTSDVER----DLVKEAVKML GHMNALDHIIAVAAEQ----------------G------------IKDIKLLLEAK-P >ENSGACP00000027247 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------MF----- ------------------------------------------------------------ --------------------KKAKRANFRRRNASDEED-------QEE------------ ------------------------------------------------------------ -----------------GRQ--------------------PPA----AP----------- ------------------------------------------------------------ LPS--------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------FG--------------------------------------------- ----------P------------------------------VAEEI-------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------P-------------------------------------------- -----------------------FME--TSE----------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----N--S----------------------------------VPAAPSGADNYHSNGLQ LNVCNVRAVKKEKKGKEPPVVTATPA---------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------GPTKAS----------------- ------------------LLSF-DDD--E-EE---------------------------- ---------------------------------------------------------S-- ------EVFRVKKSNHSKKIVKQLKKEYKE------------------------------ ----------------------DLEKSG-------------------------------- ----VKQDVRS------------------------------------DAPPQTLVSIKEE VI------------------------------------SRVG------------------ --------------------------------------------SDHGEEEMEVDS---- TEEEE------------------------------------------------------- -----------------------------------------------------------S NHTGASFNTLSSLSSLRP-----------GEIPDAAFIHAARKRRQLAREQGGEAPLIET D-TPKKRMVREED---QDA-SD-DEDEEEKRIRFSGVKNLSQRQKIAEE--I---GIEGS DDEALD-T-GQDEEVSRWEQEQIRKGISIPQVQSIQPEDN-TVYYQNSYESQPYGSAYCM PFTY--STAAPHTAKPTGRADNGSVHYG-T---------------------------PIG DLTPVSIDLVKKRLQD-R------------------------------------------ ----------------------LGQMRAGHNANAGRYKQIEEDLAASESAILQLEASSND DADQYKFLQEMRGYVGDLLECFSEKVPAVLELEAAMHQLLRQRASRLVQRRQDDIKDESS EFASLS-------------------SKAVMAPNLDSFGRDRAAYQENSRQRRIAERE--- ---ARR-TRR-RQAREQNGKRAEHKEGLSSDDEETSTDITSFNTER--DRIVRECKKVFE DVVEDFHSLDCIKSHFEVWRREYADCYRDAYIGLCLPKLFNPLVRLQLITWNPLE----- -------------------------------TPCANFEYMLWFESLLFYGFEEHSV-LQR GDGDIGLLPAIVEKVILSKLTVLAEQVWDPLSDS--------------QTAGLVGFIHRL MKGYPTVLHGDNRY-----TQELLRTIVFRTRRTLDEDVFLPLYPKNVLENKNSGPYLFY QRQFWSCVKLLDNILQWEGILSSSCLKDLALDSTVNRYILSALQSTDTGADNVPKCQKVV QCLPVHWFSGLKGQHTLPQLEPFCRYLTHLASSLYRGSLGGSDVERRTAKDQVKEVVKLL GNMNALNHIIAVAAEH----------------G------------IKDIKPFLEAK-S >ENSCGOP00000020719 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------M------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------SPTRKNRRRVGSRQCRRYRLGLPWRKSRSWRLPSALPA-------------- ------------------------------------------------------------ ------------------------------------------------------------ ---APSSTDNYH---------------------------------------------SNG FQA--NILKAVKKEKKVKDT---------------------------------------- -----------------------------AIVTAAVPAPTKAS----------------- ------------------LLSF-DDD--E-EG---------------------------- ---------------------------------------------------------S-- ------EVFRVKKSNHSKKIVKQLKKEYKE------------------------------ ----------------------DLEKSG-------------------------------- ----VKHEHRS------------------------------------DAPLQPAVAIKEE VT------------------------------------SRAG------------------ --------------------------------------------SDQGEEEMEVDS---- ADDQQEEVK--------------------------------------------------- ----------SQG----GHPQ---------------------------------GQVSRS NHSVSTFNTLSSLGSLKP-----------GEIPDAAFIHAARKRRQLARELGGEAPLVET E-TPKKRMAQ-ED---QDA-SD-DEDEDEKRIRFSGVKNKSQRQKIAEE--I---GIEGS DDEALD-T-GQDEEVIRWEQEQIRKGISIPQVQSSQPEDN-TVYYQNSYETQPYGSSYSM PFTY--STVAQQTVKPTGRADNGSVHYG-T---------------------------PIS DLTPVSIDLVKKRLQD-R------------------------------------------ ----------------------LSQMSAGHDANARRYKQIEEDLAASESAIQQLEGSSNN NSDQYKFLQEMRGYVGDLLECFSEKVPAVLELEAAMHQLLRQRASRLVQRRQDDIKDESS EFASLS-------------------NKAVMAPNLDSFGRDRAAYTENSRQRRIAERE--- ---ARR-TRR-RQAREQNGKRAEHKEGLSSDDEETSTDITSFNMEK--DRIIRECKKVFE DVVEDFHSLDCIKSHFEVWRKEYADCYRDAYIGLCLPKLFNPLVRLQLITWNPLE----- -------------------------------SQCANFEYMLWFESLLFYGFEEHSV-LQR GDGDSSLLPAIVEKVILSKLTVLAEQVWDPLSNS--------------QTARLVGFIHRL MKGYPTVLHGENRY-----TQELLKTIVFRARRTLDEDVFLPLYPKNVLENKNSGPYLFY QRQFWSCVKLLGNILQWEGILSSSCLRDLALDSTLNRYILCALQTTDTGEDNVPKCQKVV ECLPVQWFSGLKGQQTLPQLEPFCRYLTHLANSFNRSSLGGSDLERRSAKDLIKEVVKML GQMNALDHIITVAAEH----------------G------------IKDIKPLLEAK-S >ENSGWIP00000006562 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------MF----- ------------------------------------------------------------ --------------------KKAKRANFRRRNESDEEE-------QE------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------GGS------------------ ----------HSSQTCP------------------------------------------- ---------------------------------------------------------SNG FLADVNSFRAVKRDKRPKEAAP-------------------------------------- ------------------------PLV-----------PSKAS----------------- ------------------LLSF-EDD--E-DD---------------------------- ---------------------------------------------------------S-- ------EVFRVKKSNHSKKIVKQLKKEYKE------------------------------ ----------------------EVEK---------------------------------- --------------------------------------------YV---PMQPMFTIKEE VT------------------------------------SVAC------------------ --------------------------------------------SKHGEEEMEVES---- ADEPEEETK--------------------------------------------------- ------------------------------------------------------------ ----AAFNTLSSLSTLRP-----------GEIPDAAFIHAARKRRQLARELGGEAPLVET E-TPKKRLVQ-ED---QDA-SD-D-DDEEKRISFSGVRNKTQRQKIAEE--I---GIEGS DDEALD-T-GHDEEVSRWEQEQIRKGISIPQVQSSQPEEN-TVYYQNSYETQPYGSSYSM PFTY--SSMVSQPIKAAGHADNGSVHYV-T---------------------------PVS ELTTVSIDLVKKRLQV-R------------------------------------------ ----------------------LGEMNAGYEANSKRYEQIKEDLAASESSIEQLEGSSNE NADQYKFLQEMRGYVGDLLECFSEKVPAVLELEAAMHQLLRQRATRLVQRRQDDIKDESS EFASLS-------------------NKAVMAPSLDSFGRDRATYQEHSRQRRIAERE--- ---ARR-TRR-RQAREQNGKRAEHNEGLSSDDEETSTDITAFNMEK--DRIIKESKKVFE DVVEDFHSLDCIKRHFEDWRRDYVDCYRNAYIDLCLPKLFNPLVRLQLITWNPME----- -------------------------------DQCANFEYMLWFESLLFYGFDEHST-LKK GDADIGLLPAIVEKVILSKLTVLAEQVWDPLSNS--------------QTSRLVAFIIRL MKGYPTVMHGDNRY-----TQELLKAIVLRTRRTLDEDIFLPLYPKSVQDNKNSGPYLFY QRQFWTCIKLLRNILLWEGILSASCLKDLAFDSTLNRYILSALQTTDTIEENLLKCQKVV ECLPEHWFSGLKGQQTLPQLEPLCRYITHLANLLHRSSLGASDVGR----HQVKEALKML GRMNALDHIIAMATEH----------------G------------MKDIKPLLELK-S >ENSCSEP00000014574 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------MF----- ------------------------------------------------------------ --------------------KKAKRANIRRRNESDEDE-------QEE------------ ------------------------------------------------------------ -----------------GQR--------------------PP------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------LAP--------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------TSFG--------------------------------------------- ----------P------------------------------VVEEI-------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------P-------------------------------------------- -----------------------FME---------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------------------TSTN- ----------------------ASA---------QYHT---------------DSTHSNG FLSNTNIIRGFKKEKKVKDIPVV------------------------------------- ------------------------L------------GPTKGS----------------- ------------------LLSFDDDE--E-EG---------------------------- ---------------------------------------------------------L-- ------EVFKVKKSTHSKKIVKQLKREYKE------------------------------ ----------------------DLEKTE-------------------------------- ---ITRPDSKS------------------------------------DAPLLPLVSIKEE VI------------------------------------SKTG------------------ --------------------------------------------SDQGEEEMEVDS---- NDEQNDTGR--------------------------------------------------- ----------NQA----GQAQ---------------------------------SQMSKS NNPGAAFNTLSSLGNLRP-----------GEIPDAAFIHAARKRRQLARELGGDAPLVEA E-APKKRHAS-ED---QDV-SD-DEDEAEKRIRFSGVKKKSQRQKIAEE--I---GIEGS DDEALD-T-GQDEEVTRWEQEQIRKGISIPQVQTTQPEDT-TIYYQNSYESQPYGASYSM PFTY--STVAPTSAKTTGRADNGSVHFG-A---------------------------QIT DLPPVSIDLVKKRLQD-R------------------------------------------ ----------------------LSHMRAGHQANSKHFRQIDDDLASSENSIQQLEGSSND NEEKYKFLQEMRGYVGDLLECFSEKVPAILELEAAMHQLLRQRTSRLVQRRQDDIKDESS EFASLS-------------------NKAVMAPNLDSFGRDRAAYQEHSRQRRIAERE--- ---ARR-TRR-RQAREQNGKRAEHKEGLSSDDEETSTDITSFNMEK--ERISRECKKVFE DVVDDFHSLDFIKSRFEVWRRDFPDSYRDAYIGLCLPKLFSPLVRLQLITWSPLE----- -------------------------------AQCANFEYMLWFESLLFYGFEENIA-LQK DDGDIGLLPAIVEKVILSKLKVLVEQAWDPLSTN--------------QTARLVSFIRRL LKGYPTVLHGDNQY-----TQELLKSIVLRTRRTLDEDVFLPLYPKNVLDNKNSGPYLFY QRQFWSCVKLLGNILQWDGILSTSCLKDLALDSTLNRYILSALQTTDTAEENVHKCQKVV EVLPQHWFLGMKAQQTLPQLEPLCRYLGHLANTLHRSSVSGSDLERHSVKDQVKEVVRML GYMKALDHIMSVAAEF----------------G------------FKDIKPLLEAL-S >ENSTNIP00000012857 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------MF----- ------------------------------------------------------------ --------------------KKAKRANIRRRNESDEEE-------QDE------------ ------------------------------------------------------------ -----------------TRQ--------------------PL------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------LAS--------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------TLFG--------------------------------------------- ----------P------------------------------VVNEI-------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------P-------------------------------------------- -----------------------FIE---------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------------------SSSNS VTG----------------------------------LVGATDNHHSNGIQAHG------ -------VRPVRKDKKVKD----------------------------------------- --------------------------------VGTVSGPTKAS----------------- ------------------LLSF-DDD--EAEG---------------------------- ---------------------------------------------------------S-- ------EVFRVKKSNHSKKIVKQLKREYKE------------------------------ ----------------------DLEKSG-------------------------------- ---CVKQESKS--------------DCQAQSAVSVKDEPSGKV----------------- -----------------------------------------G------------------ --------------------------------------------SDHGEEEMEVDS---- ADEQD------------------------------------------------------- ----------------------KG----------------------RSV----------- ----ATFNTLSSLSSLRP-----------GEIPDAAFIHAARKRRQLARELGGDAPLVET E-APNKHLVE-ED---QDA-SD-DED--EKRIRFSGVKNKTQRQKIAEE--I---GIEGS DDEALD-T-GQDEEVSRWEQEQIRKGISIPQVQSSQPEDN-MVYYQNSYEGQPYGTSYSM PLTY--SSVNTQAVKLAVQTDNGSIHFG-P---------------------------AIS DLNPVSVDLVKKRLQD-R------------------------------------------ ----------------------LAHMYAGHNANTKHYKQIGEDLAASESTIKQLEGSSTD KADQYKFLQEMRGYVGDLLECFSEKVPAVLELEAAMHQLLRQRASRLVQRRQDDIKDESS EFASLS-------------------SKAVMAPNLDTFGRDRAAYQEQRRQRRIAERE--- ---ARR-TRR-RQAREQNGKRAEHNEGFSSDDEETSTDITSFNAER--DRIVNESKKVFE DVLEDFHSLDYIKCHFEVWRRDYAECYREAYIGLCLPKLFNPLVRLQLITWNPLE----- -------------------------------GECDNFEYMLWFESLLFYGFDEHAA-LQK GDGDNGLLPSIVEKVILSKLAALAEQVWDPLSRS--------------QTARLVEFLHRL RKGYPTVLHGDNKY-----TQELLKTIVLRTRRTLDEDIFLPLYPKSVLDNKNGSPYLFY QRQFWSCAKLLGNILMWEGILSISCLKDLALDSTLNRYILSALQTTDAGEENVHRCQKVV ECLPPLWFSGLKGQQTLPQLEPLCRYLVHLANSLHRSSLGTSDLERRTTKDLIREVVKML VHMKALDHIISLAAEQ----------------G------------IKDIKQLLEA--- >ENSTRUP00000003355 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------MF----- ------------------------------------------------------------ --------------------KKAKRANIRRRNESDEDE-------QDE------------ ------------------------------------------------------------ -----------------TRQ--------------------TP------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------LAS--------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------TLFG--------------------------------------------- ----------P------------------------------VVDEI-------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------P-------------------------------------------- -----------------------FIE---------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------------------TSGNS VAG----------------------------------LAGAADNHLNNGIHAFN------ -------VRAVKKDKKVKE----------------------------------------- --------------------------------AVTVPGPTKAS----------------- ------------------LLSF-DDD--E-EG---------------------------- ---------------------------------------------------------S-- ------EVFRVKKSNHSKKIVKQLKREYKE------------------------------ ----------------------DLEKSG-------------------------------- ---SVKQDSKS--------------DFQAYSVVPVKDEASCKV----------------- -----------------------------------------G------------------ --------------------------------------------SDHGEEEMEVDS---- TDEQE------------------------------------------------------- ----------------------QGGKTQIGK--------------SKSA----------- ----ATFNTLSSLSSLRP-----------GEIPDAAFIHAARKRRQLARELGGDAPLVET E-VSNKHLVE-ED---QDA-SD-DED--EKRISFSGVKNKTQRQKIAEE--I---GIEGS DDEALD-T-GQDEEVSRWEQEQIRKGISIPQVQSSQPEDN-MVYYQNSYESQPYGTSYSM LLTY--NSVNAQAAKPAVQTDNGSIHYG-A---------------------------AVS DLSPVSIDLVKKRLQD-R------------------------------------------ ----------------------LGHMYAGHNANTEHYKQIEEDLAASEGSIQQLEGSSTD KADQYKFLQEMRGYVGDLLECFSEKVPAVLELEAAMHQLLRQRASRLVQRRQDDIKDESS EFASLS-------------------NKAVMAPNLDTFGRDRAAYQEQRRQRRIAERE--- ---ARR-TRR-RQAREQNGKRAEHNEGFSSDDEETSTDITSFSMEK--ERIVTEAKKVFE DVVEDFHSLDYIKSHFEVWRRDYAECYREAFIGLCLPKLFNPLVRLQLMTWNPLE----- -------------------------------VECENFEYMLWFESLLFYGFDEQTA-LQK GDGDNGLLPSIVEKVILSKLTVLVEQVWDPLSRS--------------QTALLVEFLHRL RKGYPTVLHGDNKY-----TQELLKTIVLRTRRTLDEDIFLPLYPKSVLDNKNSGAYLFY QRQFWSCVKLLGNILMWDGILSLSCLKDLALDSTLNRYILSALQTTDVGEDNVQKCQKVV ECLPVPWFSGLKGQRTLPQLEPLCRYLAHVANSLHRSSLGVSDLERRTARDLIREAVKML VHMKALDHIISVAAEQ----------------G------------IKDIKQLLEI--- >ENSHCOP00000026936 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------MF----- ------------------------------------------------------------ --------------------KRIKRANFRRRNESDEDE-------REE------------ ------------------------------------------------------------ -----------------NVQ--------------------PM------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------LAP--------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------TLFG--------------------------------------------- ----------P------------------------------VLEEV-------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------P-------------------------------------------- -----------------------FLE---------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------------------TS--- ------------------------SGSNDVSLSPR----------------------SNG F---------------------GVNF---------------------------------- ---------KSVRRDKKAKDGAPVL------------GPTKAS----------------- ------------------LLSF-DDDEEE-EG---------------------------- ---------------------------------------------------------P-- ------EVFRVKKSNHSKKIVKQLKKEYKE------------------------------ ----------------------DLEKCG-------------------------------- ---VVK----------------------------------------TEAVPQPIVAIKEE VI------------------------------------SKVV------------------ --------------------------------------------SEHGGDEMEVDS---- ADEQREEVK--------------------------------------------------- -----------------------------GNQVQRS-----------------------S NNTGATFNTLSSLNTLRP-----------GEIPDAAFIHAARKRRQLARELGGDAPLVET E-APKKRMAQ-ED---QDG-SD-DEDEEEKRIRFSGVRSKTQRQKIAEE--I---GIEGS DDEALD-T-GHDEEVSRWEQEQIRKGISIPQVQSSQPEDT-AAYYQNSYDTQPYGTGYNM PFTY--SVVPPQASKPP--ADGTSAHFG-L---------------------------SVS DLAPVSIDLVKKRLRD-R------------------------------------------ ----------------------LGHMRTGHNANINRYTQIQEDLAASESAIMQLDGSSND NADQYQFLQEMRGYVGDLLECFGEKVPAIEELEAAMHQLLRQRASRLVQRRQDDIKDESA EFASLS-------------------NKAVMAPSLDSFVRDRTLYQESSRQRRIAERE--- ---ARR-ARR-RQAREQNGKWAEHKEGLSSDDEETSTDITSFSVEH--DRITRECQKVFE DVLEDFHSMDYIKSQFEAWRRNYAECYKDAYIGLCLPKLFSPLIRLQLITWNPLE----- -------------------------------AQCTNFEYMLWFETLLFYGFEEHST-LQK GDSDIGLLPAIVEKVVLTKLTVLSEQVWDPLSNS--------------QTARLVGFIRRL MKGYPTVLHGDNQF-----TRELLRTVVLRVRRTLDEDVFQPLYPKNLLENKNGGPYLFY QRQFWSCVKLLGNILQWEGIISTSCLKDLALDSTLNRYILSALQTTEASEDNVHKSQKVV DCLPMQWFNGLKGQQTLPQLEPLCRYLVHLANSLNRSSLGASDVERRVTKDQVKEIVKML VYMKAVDHIIAVAAEQ----------------G------------IKDIKSLLETK-S >ENSPKIP00000005039 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------MF----- ------------------------------------------------------------ --------------------KKAKRVNFRRRNESDD------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------DE--K-EDGREPQIATPPVPQQPCGPAVEEGSIRDP DAHNSEAVPGGTVTVHHGNGLQLSVGKAVKEKKKNNKDGRDAPRASLLSFHDDEGKNT-- ------EVFRVKKPNHSKKIVKQLKKEYKE------------------------------ ----------------------DLEKNS-------------------------------- ---TIRQETTASTDE---TVAP-------------------------------------- ------TLV-------------------TVKEEPKAEGSRAS------------------ --------------------------------------------SEQGEEEMEVDS---- NEEPDED-------------------------------------------------GEPR GGA-GAAFS--------------------------------------------------- -------NTLSSLSTLRP-----------GEIPDAAFIHAARKRRQLARELGADGPAPEP E-GGKKRLVR-ED--EHDG-S--DDDEDEKRIVFSGVKMKTQRQKIAEE--I---GIEGS DDEALD-TAGNDEEVSRWEQEQIRKGISIPQVQTNPPEDA-NMYYQSGYDVQPYGTSYSL TYSY--NSV-----------------------------AGD-DSKA-KADTSVTFSAPSS DLTPITTDLVKKRLKD-R------------------------------------------ ----------------------LSSVRQGHSSNAKRYEQIQEELASSARTIQRLEGSSDA VADQYKFLQEMRGYVRDLLECFGEKVPVILELEAAMHQLLMQRASRLVQRRQDDIKDESA EFSSLS-------------------NKALMAPNLDSFGRDRAAYQEHAKQRRIAERE--- ---ARR-TRR-RQAREQNGKRAAHREGLSSDDEETSTDITSFNLER--ERILKDSKKVFE DVLEDFQSLDGIKSRFEVWRKLYSACYQDAYIGLCLPKLFSPLVRLQLIGWFPLE----- -------------------------------VDCPNFEYMLWFESLLFYNCEEQSE-MQK DDVDVGLLPAIVEKVILPKLAVLVDQVWDPLSSN--------------QTSRLVAFMQRL IKGYPTVLHGDNRN-----TQELLKTIVLRTRRTLDNDIFMPLFPKNILENKNSGPYLFF QRQFWSCVKLLENILQWYGILSNCTLRELAVDSTLNRYILSALQSTDPGEESIDKSRSVV ECFPQQWFSSLKGQQTIPQLENFCRYLKHVASTVYRISLAGSDMERRNAREQIKEVVKLL GRINALDHVVAVATEH----------------G------------IKDIKTLLESK-- >ENSSFOP00015010256 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------MF----- ------------------------------------------------------------ --------------------KKAKRVNFRRRNDSDDEE-------QED------------ ------------------------------------------------------------ -----------------SQ----------------------------------------- ------------------------------------------------------------ --Q--------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------AET--------------------PF PAGLHGEL---------------------------------------------------- ------------------------------------------------------------ --------------H--------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ----------HGNGFQAN---PLKTSKE-----------------------------KKK NKEARE--AP-------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------KAS----------------- ------------------LLSF-QDE--E-ED---------------------------- ---------------------------------------------------------T-- ------EVFRVKKPNHSKKIVKQLKKEYKE------------------------------ ----------------------DLEKSN-------------------------------- ---SVKQETSATTNEVSAVVAP-------------------------------------- ------------------------------KEESKAEGSQAS------------------ --------------------------------------------SEQGEEEMEVDS---- NDDQEEE-------------------------------------------------SEPR SNT-GGSFS--------------------------------------------------- -------NTLSSLSVLRP-----------GEIPDAAFIHAARKRRQLARELGGDLPPPEM E-VGKKRLVR-ED--EQGG-S--DEDEDEKRIVFSGVRQKTQRQKIAEE--I---GIEGS DDEALD-AAGHDEELSRWEQEQIRKGISIPQVQTNQPEET-NMYYQNSYEVQPYASSYGL PYSY--SSV-----------------------------GGD-DSKA-KSDSSVTYCAPSS DLTPITTDLVKKRLTD-R------------------------------------------ ----------------------LSTVRQVHCSNAKRYGQIQEELEASVRTIQRLEGSSDA VADQYKFLQEMRGYVRDLLECFSEKVPLILELEAAMHQLLRQRASRLVQRRQDDIKDESA EFSSLS-------------------SKALMAPNLDSFGRDRGAYLEHAKQRRIAERE--- ---ARR-TRR-RQAREQNGKRAEHHEGLSSDDEETSTDITSYNLER--ERILKESKKVFE DVLEDFHSLDTIKVHFEEWRRLYSACYQDAYIGLCLPKLFTPLVRLELMDWSPLE----- -------------------------------VDCRNFEYMLWFESLLFYGCEDQSK-MQK GDVDVGLLPAIVERVIIPKLAVLADQVWDPLSSS--------------QTARLVAFVHRL IKGYPTVLHGRNRN-----TQELLKTIVFRTRRTLDNDIFMPLYPKNALENKNSGPYLFF QRQFWSCVKLLGNILQWHGILSDATLRELAVDSTLNRYILSALQNTEPGEDSIEKSCSVV ECFPQQWFSNLKGQQTIPQLENFCRYLKHVASTVYRISLAGSDVERRNAREQIKEVVKLL GRINALDHVIAIATEH----------------G------------IKDIKTLLENK-- >ENSLOCP00000010922 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------MF----- ------------------------------------------------------------ --------------------KKAKRVNFRRRNESDDEE-------NEE------------ ------------------------------------------------------------ -----------------SQ----------------------------------------- ------------------------------------------------------------ -PQ--------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------A------------------------ -------LQQQ------------------------SCGPA-------------------- -----------------------------------------------DETCLREAGVNNS ELGSANVPASEDVVH--------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ----------HGNGLQSNAAKP----KE-----------------------------KKK IKDNKE--AP-------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------KAS----------------- ------------------LLSF-HDE--E-DD---------------------------- ---------------------------------------------------------T-- ------EVFKVKKSNHSKKIVKQLKKEYKE------------------------------ ----------------------DLERTG-------------------------------- ---TVKQE---------------------------------------------------- -----------------------------------------SSAAVDEPMTVAVTMKDDL RLEGSLP------------------------------------CSEQGEEEMEVDS---- NEESEEDQK--------------------------------------------TSA---- ----GGAFS--------------------------------------------------- -------SALSSLSTLRP-----------GEIPDAAFIHAARKRRQLAREL-GDAIPMES E-VGKNRLVR-ED--EHDA-SD-DEDDDEKRRIVFSVREKTQRQKIAEE--I--AGIEGS DDEALD-AGGQDEELSRWEQEQIRKGISIPQVQASQPEDV-TMYYQSSYEASSYGSSYGL PYTY--SSV-----------------------------GSE-DSKQLKSESSVTYSAPSS EMTPITTDLVKKRLKDSR------------------------------------------ ----------------------LNSMREVHSSNKKRYEKIQQELESSTNMIERLEGSSDG VADQYKFLQEMRGYVRDLLECFSEKVPLILELESAMHQLLRQRAARLVQRRQDDIKDESS EFASHS-------------------SKALMAPNLDSFGRDRGAYQEHAKQRRIAERE--- ---ARR-ARR-RQAREQNGKRAEHCEGLSSDDEETTTDITSFNLEK--ERILKESKKVFE DVLEDFHSLDCIKARFEVWRRLYFKCYQDAYIGLCLAKLFSPLVRLQLISWSPLE----- -------------------------------ANCPNFEYMLWFEALLFYGCEEQSN-LPK GDVDINLLPSIVERVILPKLAVLADQVWDPFSTN--------------QTTRLVVFMHKL IKGYPTVLHGENRN-----TQELLKTIVMRTRRTLDNDVFMPLYPKNVLENKNSGPYLFF QRQFWSCVKLLGNILQWHGVLSNTSLRELAVDSMLNRYILSALQSTDPGEDSIEKTQSVI SCFPKQWFTSLKGQQTLPQLENVCRYLKHVANTVYRLSLGGSDVDKRNARDHIKEVVKLL GSINALDHAMAVSTEH----------------G------------IKDFKALLDGK-- >ENSAMXP00005055986 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------MF----- ------------------------------------------------------------ --------------------KKARRCNFRRRNDSEDEE-------KDEL----------- ------------------------------------------------------------ ------------------Q----------------------------------------- ------------------------------------------------------------ -NE--------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------LQPQSAEQQQQQQQHQPPA P-----------------------------------CGPG-------------------- ------------------------------------------------------------ ---------------------------AG------------------------------- --------------------------GDS------------------------------- ----------------------------------------------------------GT ASADSNAVNNHGNGFQSS---ALKAARE-----------------------------KKR KKEGKE--EP-------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------KAS----------------- ------------------LLSF-NDE--E-EE---------------------------- ---------------------------------------------------------T-- ------EVFRVKKSNHSKKIVKQLKKEYREEK------------------------IVHV VQDVTTRLDGASGPAIVKDEPVD------------------------------------- ------------------------------------------------------------ --------------------------------------SRGS------------------ --------------------------------------------SEQGEGEMEVDS---- NDEPEDE-------------------------------------------------SEAK PGG-GGAFS--------------------------------------------------- -------ETLSALSSLRP-----------GEIPDAAFIHAARKRRQMARELGGDAPLVEA E-VANKRLVH-ED--EQGG-S---DDEDEKRIVFSGVKQKSQRQKIAEE--I---GIEGS DDEALD-TEGNDEEVSRWEQEQIRKGISIPQVQTSQPEDA-NMYYQAGYEGQPYGVSYNM PYGY--AAV-----------------------------GAD-SSKPVKAEGPVPYPIPSS SLTPITTALVKKRLTD-R------------------------------------------ ----------------------LSSMRQGRDASARRYEQIQEELQASNSSILQLEDSSQH TAEQYKFLQEMRGYVRDLLECFSEKVPAVLELEAAMHQLLRQRAARRVQRRQDDIKDESA EFSSLS-------------------NKAVMAPNLDPFGRDRAAYQELGKQRRVAERE--- ---ARR-TRR-RQAREQSGKRAEHKEGLSSDDEETSTDINSFNLER--DRVLKESKKVFE DVVEDFHSLDCIKSRFEVWRKLYFTCYRDAYIGLCLPKLFNPLIRLQLIPWSPLE----- -------------------------------DECPNFEYMLWFESLLFYGCEELTN-TRE EDIDIGLLPAIVERVVLPKLAVLAEQVWDPLSRR--------------ETSRLVAFMMRL IKGYPTVLHGENRN-----TQELLRTVVMRIRRSLDEDIFMPLFPKNVLENKNSGPYLFS QRQFWTCVKLLGNILQWDGILSQSTLKELAVDSTLNRYILSALQMADFGEDSVEKCRRVV EYFPVHWFSTLKGQQTLPQMENLCRYMKHLATSLYRSSLTASDVDKRNVREHIKEVVRLL GRLNALDHVITVASEH----------------G------------IKDIKTLLETK-- >ENSPNAP00000019060 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------MF----- ------------------------------------------------------------ --------------------KKARRCNFRRRNESEDEE-------KDELLSA-------- ------------------------------------EQPPPPPPASYGPAAAAAGD---- -----------LGAASGE------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----SNAVNSHGNGFQAA---AVKTAKE-----------------------------KKK KKESRE--EP-------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------KAS----------------- ------------------LLSF-NDD--E-ED---------------------------- ---------------------------------------------------------T-- ------EVFRVKKSNHSKKIVKQLKKEYREEKS---------------VPSLPSTG---- ----------------VKDEPED------------------------------------- ------------------------------------------------------------ --------------------------------------SRGS------------------ --------------------------------------------SEQGEGEMEVDS---- NDEQDDE-------------------------------------------------SEAK SSG-GGAFS--------------------------------------------------- -------QTLSALSSLRP-----------GEIPDAAFIHAARKRRQMARELGGETPLVDM E-VANKRLVR-ED--EQGG-S----DEDEKRIVFSGVTQKSQRQKIAEE--I---GIEGS DDEALD-TAGNDEEVSRWEQEQIRKGISIPQVQTSQPEDT-NMYYQGGYEGQPYGVSYGM PYGY--AAV-----------------------------GAD-SSKPVKAESSVPYPIPSS SLTPITTALVKKRLTD-R------------------------------------------ ----------------------LSSMRQGRDASAQRYEQIQEELQASNSSILQLEESSQH TAEQYKFLQEMRGYVRDLLECFSEKVPAVLELEAAMHQLLRQRAVRRVQRRQDDIKDESA EFSSLS-------------------SKAVMAPNLDPFGRDRAAYQELSKQRRIAERE--- ---ARR-SRLCVQAREQSGKRAEHKEGLSSDDEETSTDITSFNLEK--DRILKESKKVFE DVIEDFHSLDCIKSRFEVWRKLYFTCYRDAYIGLCLPKLFNPLIRLQLIPWSPLE----- -------------------------------DDCPNFEYMLWFESLLFYGCEEQTN-TQE EDIDTGLLPAIIERVILPKLAVLSDQVWDPLSRS--------------ETCRLVAFMRRL IKGYPTVLHGENRN-----TQELLRTIVIRTRRSLDEDVFMPLFPKNVMENKNSGPYLFS QRQFWSCVKLLGNVLQWDGILSQNTLKELAIDSTLNRYILSALQMADVGEDSVEKCQQVV ECFPVHWFSTLKGQQTLPELENLCRYMKHLASSLYRSSLTASDVDKRSAREHIKEVVKVL GRLNALDHVIAVASEH----------------G------------IKDIKTLLESK-- >ENSIPUP00000005791 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------MF----- ------------------------------------------------------------ --------------------KKAKRCNFRRRNDSDDDE-------KDEV----------- ------------------------------------------------------------ ------------------Q----------------------------------------- ------------------------------------------------------------ -DEPSQEV---------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------PQPQP------------------ --QP-------------------------------------------------------- ---------------------------------------C-------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------G--------------------------------------------- ----------P------------------------------VV----------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------DSSHTPAAETLTAI------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----NAVNSHGNGVQMG---AMKLSKD-----------------------------KKK KKECRE--EP-------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------KAS----------------- ------------------LLSF-NDE--E-ED---------------------------- ---------------------------------------------------------T-- ------EVFRVKKSNHSKKIVKQLKKEYREEKSSHVKSNHHFIVKEEAA----------- ----------------------D------------------------------------- ------------------------------------------------------------ --------------------------------------SRGS------------------ --------------------------------------------SEQGEGEMEVDS---- NDEQDEE-------------------------------------------------SEAK Q---GGNFS--------------------------------------------------- -------QTLSALSSLRP-----------GEIPDAAFIHAARKRRQMARELGGEAPLVET D-ASSKRLVR-ED--EQGG-S---DDEDEKRIVFSGVKQKSQRQKIAEE--I---GIECS DDEALN-TEGHDEEVSRWEQEQIRKGISIPQVQTSQPEDA-NMYYQTGYENQQYATSYSM PYGY--TAL-----------------------------GSE-SVKPVKAENTVPYPIPSS SLTPITTALVKKRLMD-R------------------------------------------ ----------------------LSSMRQGRDASARRYEQIQEELQASDNSILQLEDSSQH AAEQYKFLQEMRGYVRDLLECFSEKVPAVLELEAAMHQLLRQRAMRRVQRRQDDIKDESA EFSSLS-------------------SKAVMAPNLDPFGRDRAAYQELSRQRRVAERE--- ---ARR-ARR-RQAREQSGSRAEHKEGLSSDDEETSTDATSFNLER--DRILKESKKVFE DVIDDFHSLDCIKSRFEVWKNLYFTCYRDAYIGLCLPKLFNPLIRLQLIPWSPLE----- -------------------------------EDCPNFEYMLWFETLLFYGYEEQST-EHL EDIDSGLLPAIVERVVLPKLAVLAEQVWDPLSHS--------------ETCRLVAFMQRI IKGYPTILHGENRN-----TQELLRTILVRTRRTLDEDVFMPLYPKNVMENKNSSPYLFF QRQFWSCVKLLGNILQWDGILSHNSLKELAVDSTLNRYILSALQSTDVGEDSVEKCRKVV ECFPLHWFSSLKGQQTLPQLENLCRYLKHMASSLYRSSLTASDVDKRIAREHIKEVVKLL GRLNALDHVITVASEH----------------G------------IKDIKTLLESK-- >ENSEEEP00000036531 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------MF----- ------------------------------------------------------------ --------------------KKAKRCNFRRRNDSDDEE-------KEEV----------- ------------------------------------------------------------ ------------------Q----------------------------------------- ------------------------------------------------------------ -NQ--------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------------QQXQQQHQ-PQ P-----------------------------------CGPGLE-D------------PD-- -------------------------------VSGADAAPGLGASVLSN------------ --------------HGNGLQPGL--AKP-------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -------------------------SKE-----------------------------RKK KKEGRE--EP-------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------KAS----------------- ------------------LLSF-NDD--E-ED---------------------------- ---------------------------------------------------------S-- ------EVFRVKKSNHSKKIVKQLKKEYREEK------------------------TSYV VQDT--------------NEVVD------------------------------------- ------------------------------------------------------------ --------------------------------------SRGS------------------ --------------------------------------------SEQGEGEMEVDS---- IDEQEED-------------------------------------------------GEAK SSG-GGAFT--------------------------------------------------- -------QTLSALSSLRP-----------GEIPDAAFIHAARKRRQMARELGGDTPLVET E-AQNKRLVR-ED--EQGG-S---DDEDEKRIVFSGVRQKSQRQKIAEE--I---GIEGS DDEALD-T-GQDEEVSRWEQEQIRKGISIPQVQTNQPEDA-NTYYQGGYEAQPYGASYGM PYAY--APV-----------------------------GADGEGRPVKAESSVTHPVPST SLTPITTALVKKRLTD-R------------------------------------------ ----------------------LSSMRQGRDASARRYEQIQQELQESTRSITSLEDSSLH TAEQYKFLQEMRGYVRDLLECFSEKVSAVLELEAAMHQLLRQRAVRRVQRRQDDIKDESA EFSSLS-------------------SKAVMAPNLDPFGRDRAAYQELSRQRRVAERE--- ---ARR-ARR-RQAREQSGKRVEHKEGLSSDDEETSTDITSFNLER--DRILKESKKVFE DVVEDFHSLDCIKSRFEVWRKLYFTCYRDAYIGLCLPKLFNPLIRLQLIPWSPLE----- -------------------------------EDCPNFEYMLWFESLLFYGYEEESS-EHP EDIDAGLLPAIVERVILPKLAVLAEQVWDPLSQS--------------DTNRLVAFMRRL IKGYPTVLHGENRNMQVRA------TVVMRTRRTLDDDVFMPLFPKNIMENKNSGPYLFS QRQFWSCVKLLGNILQWDGILSQGALKELAVDSTLNRYILSVLQTADVGEDSVEKCRRVV ECFPVHWFSSLKGQQTLPQLENLCRFMKHLAASLYRSSLAASDIDKRNAREHIKEVVKLL GRLNALDHVIDVASEH----------------G------------IKDIKTLLESK-- >ENSDARP00000114980 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------MF----- ------------------------------------------------------------ --------------------KKAKRCNFRRRNDSEDEE-------KEE------------ ------------------------------------------------------------ ------------------Q----------------------------------------- ------------------------------------------------------------ -QQSG------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------GPGAE-DSASPSESGSGPAP--- -----------------------------------------GANVL-------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------NNHGNGFQPG---AVKAVKE-----------------------------KKK RKEIRE--EP-------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------KAS----------------- ------------------LLSF-QDD--E-DE---------------------------- ---------------------------------------------------------A-- ------EVFRVKKSNHSKKIVKQLKKEYKE------------------------------ ----------------------DLEKT--------------------------------- ------------------------------------------------------------ --------VPEQSTRIGGQ-------NLTIKEEP-LEGSRAS------------------ --------------------------------------------SEQGEEEMEVDS---- NEDQEEE-------------------------------------------------GDQK SA--GGAFK--------------------------------------------------- -------ENLSALSLLRP-----------GEIPDAAFIHAARKRRQMARELGGDTPLVEN D-PTNKRLVH-ED--ENGDMD---DDEDEKRIVFSGVNTKSQRQKIAEE--I---GIEGS DDEALD-N-GQDEEVSRWEQEQIRKGISIPQVQT-QPEDT-SMYYQGSYDAQPYGASYAM PFNYATAVA-----------------------------GVD-NSKPLKAEPSVPYPIPSC ELTPITTDLVKKRLQD-R------------------------------------------ ----------------------LSFMRQGHNTNARRYQQIQEDLEASKKAIRVLEGSSVE AADKYRFLQEMRGYVGDLLECLSEKVPVILELEAAMHQLLRQRASRLVQRRQDDIKDESS EFSSLS-------------------SKAVMAPNLDSFGRDRTAYLELAKQRRIAERE--- ---ARR-TRR-RQAREQNDKRAEHKEGLSSDDEETSTDITSFDSER--ERILKESKKVFE DVVEDFHSLDNIKSHFETWRKLYYSCYRDAYIGLCLPKLFNPLIRLQLISWSPLE----- -------------------------------VECSNFEYMLWFESLLFYGCGEQSALKKE EDVDNNLLPAIVERVLLPKLAVLTDQIWDPLSNS--------------QTYRLVAFMKRL VKDYPTVLHGENRN-----TQELLRTVIMRIRRTLDDDIFLPLFPKNVMENKNSGAYLFS QRQFWSCVKFLGNILMWDGILSLSVLKDLAIDSTLNRYILSALQTTDASEEHVEKCRRVV ECFPVQWFSSLKGQQTLPPLENFCRFLKHLSSSLYRSCVAGSDVEKRNVREHIKEVIRLL GRLNALDHVITVASEH----------------G------------IKDIKTLLEKK-- >ENSECRP00000017237 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------MF----- ------------------------------------------------------------ --------------------KKVKRVNFRRRNNSEEEE-------EED--SVSSPQSLAC TTAEDSVLCNSEPVSQDTVCELHQGNGVQSVHPLLREK---------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------------------KKK NKENKD--AP-------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------KGS----------------- ------------------LLSF-QDE--E-DD---------------------------- ---------------------------------------------------------N-- ------EVFKVKKSNYSKKIVKQLKKEYKD------------------------------ ----------------------DLEKIS-------------------------------- ---NLKQELGSAAEE---TVVPFEQ-------------------------------IKEE QVQVESTLI--------------------------------S------------------ --------------------------------------------AERGEEEMEVDS---- NDESDYQ----------------------------------------------SS----- ----AGGFS--------------------------------------------------- -------NALSSLSTLRP-----------GEIPDAAFIHAARKRRQLARELG-DSVPNDT E-SGKKRISQ-ED--ENDV-SDDDDDEEKRRIIFT-VKEKTQRQKIAEE--I---GIEGS DDEALD-AGIQDEELNRWEQEQIRKGISIPQVQTNHQADS-NLYYQNVYEATAYGSSYGI SYSY--SSY-----------------------------GAE-DPKLLKPGSTGSYTSCSN SMTPISMDLLKKRLKD-R------------------------------------------ ----------------------YESMKEVHSKNRKQYEQNQQQLESSTCLIERLEGSSDG IADQYKFLQEMQGYVRDLLECFSEKVPLILDLESAMHHLLKRRASRLVQRRQDDIKDESS EFASHS-------------------SKTVVAPNLDSFGRDRKAYLENAKQRRIAERE--- ---ARR-TRR-RQSREQNGKRAEHHEGLSSDDEETSTDTTSFNLEK--ERIFQDSKKLFE DVLEDFYSIDCIKSRFEIWRKIYYRCYQDAYIGLCLPKLFNPLVRLQIIPWTPLE----- -------------------------------ANCPDFESMIWFESLLFYGCDEEEE-TQK GDVDVHLLPSIVERVIIPKLAVLIDEVWDPMSTS--------------QSARLVSFVKKL INGYPSVLNGENKS-----TQELLKTIVMRTRRTLDDDIFMPLYPKHVLENKNSGPYLFF QRQFWSCVKLIQNILMWHGILSNKCLRELALDSLLNRYILLALQNSDPGEDCILKCQSVV ECFPKQWFTNQKGQQTIPHLENFCRFLAHLTSTIYRVSIGLSDTEKRIARDHIKTVIKLL ASMHAVDHVITVASEH----------------G------------IKDVKAFLENK--