>ENSP00000328992 -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ---MF--------------------------------------------- ----------------------------------------RKARRVNVRK RNDSEEEE-------RER-------------------------------- -----------------------------------DEExx---------- ------------------------------xx------------------ -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- --------------x----------------------------------- -------------------------------------------------- -xx----------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- --------xx---------------------------------------- -------------------------------------------------- ----------------------------------------x--------- ----------xx-------------------------------------- -------------------------------------------------- ----------------xxxx-----xx----------------------- ---------------------------------------------xxx-- ------xxx----------------------------------------- -------------------------------------------------- -------------------------------------------------- -----x-------------------------------------------- ---------------xxExx------------------------------ ----------------------------------------------xxxx x-------------xPx--------------------------------- ---------------------------------xx-------------xx xxx----------------------------------------------- -------------------------------------------------- -------------------------------------------------- -----------------------------------------------xxx xxxxxxxGxxxxxxxxxRKRPRENKE--VP-------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ----------RAS-----------------------------------LL SF-QDE-EE-EN-------------------------------------- -----------------------------------------------E-- ------EVFKVKKSSYSKKIVKLLKKEYKE-------------------- --------------------------------DLEKSK------------ -------------------------------------------------- -------------------------------------------------- -IKTELN-----------S------------------------------- ---------SAESEQPLDKTGHVKDTNQEDGVIISEHGEDEMDMES---- EKEEE--------------------------------------------- ---------KPKT-GGAFS------------------------------- ---------------------------NALSSLNVLRP-----------G EIPDAAFIHAARKKRQMARELGDFTP-HDNE-PGKGRLVR-ED--ENDA- SD-DEDDDEKRRIVFSVKEKSQRQKIAEE--I---GIEGSDDDALV-TGE QDEELSRWEQEQIRKGINIPQVQASQPAEV-NMYYQNTYQTMPYGSSYGI PYSY--TAY-----------------------------GSS-DAKSQKTD NTVPFKTPSNEMTPVTIDLVKKQLKD-R---------------------- ------------------------------------------LDSMKELH KTNRQQHEKHLQSRVDSTRAIERLEGSSGGIGERYKFLQEMRGYVQDLLE CFSEKVPLINELESAIHQLYKQRASRLVQRRQDDIKDESSEFSSHS---- ---------------NKALMAPNLDSFGRDRALYQEHAK-RRIAERE--- ---ARR-TRR-RQAREQTGKMADHLEGLSSDDEETSTDITNFNLEK--DR ISKESGKVFEDVLESFYSIDCIKSQFEAWRSKYYTSYKDAYIGLCLPKLF NPLIRLQLLTWTPLE----------------------------------- -AKCRDFENMLWFESLLFYGCEERE--QEKDDVDVALLPTIVEKVILPKL TVIAENMWDPFSTT--------------QTSRMVGITLKLINGYPSVVNA ENKN-----TQVYLKALLLRMRRTLDDDVFMPLYPKNVLENKNSGPYLFF QRQFWSSVKLLGNFLQWYGIFSNKTLQELSIDGLLNRYILMAFQNSEYGD DSIKKAQNVINCFPKQWFMNLKGERTISQLENFCRYLVHLADTIYRNSIG CSDVEKRNARENIKQIVKLLASVRALDHAMSVASDH-------------- --N------------VKEFKSLIEGK-- >ENSPTRP00000070437 -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ---MF--------------------------------------------- ----------------------------------------RKARRVNVRK RNDSEEEE-------RER-------------------------------- -----------------------------------DEExx---------- ------------------------------xx------------------ -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- --------------x----------------------------------- -------------------------------------------------- -xx----------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- --------xx---------------------------------------- -------------------------------------------------- ----------------------------------------x--------- ----------xx-------------------------------------- -------------------------------------------------- ----------------xxxx-----xx----------------------- ---------------------------------------------xxx-- ------xxx----------------------------------------- -------------------------------------------------- -------------------------------------------------- -----x-------------------------------------------- ---------------xxExx------------------------------ ----------------------------------------------xxxx x-------------xPx--------------------------------- ---------------------------------xx-------------xx xxx----------------------------------------------- -------------------------------------------------- -------------------------------------------------- -----------------------------------------------xxx xxxxxxxGxxxxxxxxxRKRPRENKE--VP-------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ----------RAS-----------------------------------LL SF-QDE-EE-EN-------------------------------------- -----------------------------------------------E-- ------EVFKVKKSSYSKKIVKLLKKEYKE-------------------- --------------------------------DLEKSK------------ -------------------------------------------------- -------------------------------------------------- -IKTELN-----------S------------------------------- ---------SAESEQPLDKTGHVKDTNQEDGVIISEHGEDEMDMES---- EKEEE--------------------------------------------- ---------KPKT-GGAFS------------------------------- ---------------------------NALSSLNVLRP-----------G EIPDAAFIHAARKKRQMARELGDFTP-HDNE-PGKGRLVR-ED--ENDA- SD-DEDDDEKRRIVFSVKEKSQRQKIAEE--I---GIEGSDDDALV-TGE QDEELSRWEQEQIRKGINIPQVQASQPAEV-NMYYQNTYQTMPYGSSYGI PYSY--TAY-----------------------------GSS-DAKSQKTD NTVPFKTPSNEMTPVTIDLVKKQLKD-R---------------------- ------------------------------------------LDSMKELH KTNRQQHEKHLQSRVDSTRAIERLEGSSGGIGERYKFLQEMRGYVQDLLE CFSEKVPLINELESAIHQLYKQRASRLVQRRQDDIKDESSEFSSHS---- ---------------NKALMAPNLDSFGRDRALYQEHAK-RRIAERE--- ---ARR-TRR-RQAREQTGKMADHLEGLSSDDEETSTDITNFNLEK--DR ISKESGKVFEDVLESFYSIDCIKSQFEAWRSKYYTSYKDAYIGLCLPKLF NPLIRLQLLTWTPLE----------------------------------- -AKCRDFENMLWFESLLFYGCEERE--QEKDDVDVALLPTIVEKVILPKL TVIAENMWDPFSTT--------------QTSRMVGITLKLINGYPSVVNA ENKN-----TQVYLKALLLRMRRTLDDDVFMPLYPKNVLENKNSGPYLFF QRQFWSSVKLLGNFLQWYGIFSNKTLQELSIDGLLNRYILMAFQNSEYGD DSIKKAQNVINCFPKQWFMNLKGERTISQLENFCRYLVHLADTIYRNSIG CSDVEKRNARENIKQIVKLLASVRALDHAMSVASDH-------------- --N------------VKEFKSLIEGK-- >ENSPTRP00000023857 -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ---MF--------------------------------------------- ----------------------------------------RKARRVNVRK RNDSEEEE-------RER-------------------------------- -----------------------------------DEExx---------- ------------------------------xx------------------ -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- --------------x----------------------------------- -------------------------------------------------- -xx----------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- --------xx---------------------------------------- -------------------------------------------------- ----------------------------------------x--------- ----------xx-------------------------------------- -------------------------------------------------- ----------------xxxx-----xx----------------------- ---------------------------------------------xxx-- ------xxx----------------------------------------- -------------------------------------------------- -------------------------------------------------- -----x-------------------------------------------- ---------------xxExx------------------------------ ----------------------------------------------xxxx x-------------xPx--------------------------------- ---------------------------------xx-------------xx xxx----------------------------------------------- -------------------------------------------------- -------------------------------------------------- -----------------------------------------------xxx xxxxxxxGxxxxxxxxxRKRPRENKE--VP-------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ----------RAS-----------------------------------LL SF-QDE-EE-EN-------------------------------------- -----------------------------------------------E-- ------EVFKVKKSSYSKKIVKLLKKEYKE-------------------- --------------------------------DLEKSK------------ -------------------------------------------------- -------------------------------------------------- -IKTELN-----------S------------------------------- ---------SAESEQPLDKTGHVKDTNQEDGVIISEHGEDEMDMES---- EKEEE--------------------------------------------- ---------KPKT-GGAFS------------------------------- ---------------------------NALSSLNVLRP-----------G EIPDAAFIHAARKKRQMARELGDFTP-HDNE-PGKGRLVR-ED--ENDA- SD-DEDDDEKRRIVFSVKEKSQRQKIAEE--I---GIEGSDDDALV-TGE QDEELSRWEQEQIRKGINIPQVQASQPAEV-NMYYQNTYQTMPYGSSYGI PYSY--TAY-----------------------------GSS-DAKSQKTD NTVPFKTPSNEMTPVTIDLVKKQLKD-R---------------------- ------------------------------------------LDSMKELH KTNRQQHEKHLQSRVDSTRAIERLEGSSGGIGERYKFLQEMRGYVQDLLE CFSEKVPLINELESAIHQLYKQRASRLVQRRQDDIKDESSEFSSHS---- ---------------NKALMAPNLDSFGRDRALYQEHAK-RRIAERE--- ---ARR-TRR-RQAREQTGKMADHLEGLSSDDEETSTDITNFNLEK--DR ISKESGKVFEDVLESFYSIDCIKSQFEAWRSKYYTSYKDAYIGLCLPKLF NPLIRLQLLTWTPLE----------------------------------- -AKCRDFENMLWFESLLFYGCEERE--QEKDDVDVALLPTIVEKVILPKL TVIAENMWDPFSTT--------------QTSRMVGITLKLINGYPSVVNA ENKN-----TQVYLKALLLRMRRTLDDDVFMPLYPKNVLENKNSGPYLFF QRQFWSSVKLLGNFLQWYGIFSNKTLQELSIDGLLNRYILMAFQNSEYGD DSIKKAQNVINCFPKQWFMNLKGERTISQLENFCRYLVHLADTIYRNSIG CSDVEKRNARENIKQIVKLLASVRALDHAMSVASDH-------------- --N------------VKEFKSLIEGK-- >ENSGGOP00000016541 -------------------------------------------------- -------------------------------------------------- -------------------------xxxxxx------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- --GMF--------------------------------------------- ----------------------------------------RKARRVNVRK RNDSEEEE-------RER-------------------------------- -----------------------------------DEExx---------- ------------------------------xx------------------ -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- --------------x----------------------------------- -------------------------------------------------- -xx----------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- --------xx---------------------------------------- -------------------------------------------------- ----------------------------------------x--------- ----------xx-------------------------------------- -------------------------------------------------- ----------------xxxx-----xx----------------------- ---------------------------------------------xxx-- ------xxx----------------------------------------- -------------------------------------------------- -------------------------------------------------- -----x-------------------------------------------- ---------------xxExx------------------------------ ----------------------------------------------xxxx x-------------xPx--------------------------------- ---------------------------------xx-------------xx xxx----------------------------------------------- -------------------------------------------------- -------------------------------------------------- -----------------------------------------------xxx xxxxxxxGxxxxxxxxxRKRPRENKE--VP-------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ----------RAS-----------------------------------LL SF-QDE-EE-EN-------------------------------------- -----------------------------------------------E-- ------EVFKVKKSSYSKKIVKLLKKEYKE-------------------- --------------------------------DLEKSK------------ -------------------------------------------------- -------------------------------------------------- -IKTELN-----------S------------------------------- ---------SAESEQPLDKTGHVKDTNQEDGVIISEHGEDEMDMES---- EKEEE--------------------------------------------- ---------KPKT-GGAFS------------------------------- ---------------------------NALSSLNVLRP-----------G EIPDAAFIHAARKKRQMARELGDFTP-HDNE-PGKGRLVR-ED--ENDA- SD-DEDDDEKRRIVFSVKEKSQRQKIAEE--I---GIEGSDDDALV-TGE QDEELSRWEQEQIRKGINIPQVQASQPAEV-NMYYQNTYQTMPYGSSYGI PYSY--TAY-----------------------------GSS-DAKSQKTD NTVPFKTPSNEMTPVTIDLVKKQLKD-R---------------------- ------------------------------------------LDSMKELH KTNRQQHEKHLQSRVDSTRAIERLEGSSGGIGERYKFLQEMRGYVQDLLE CFSEKVPLINELESAIHQLYKQRASRLVQRRQDDIKDESSEFSSHS---- ---------------NKALMAPNLDSFGRDRALYQEHAK-RRIAERE--- ---ARR-TRR-RQAREQTGKMADHLEGLSSDDEETSTDITNFNLEK--DR ISKESGKVFEDVLESFYSIDCIKSQFEAWRSKYYTSYKDAYIGLCLPKLF NPLIRLQLLTWTPLE----------------------------------- -AKCRDFENMLWFESLLFYGCEERE--QEKDDVDVALLPTIVEKVILPKL TVIAENMWDPFSTT--------------QTSRMVGITLKLINGYPSVVNA ENKN-----TQVYLKALLLRMRRTLDDDVFMPLYPKNVLENKNSGPYLFF QRQFWSSVKLLGNFLQWYGIFSNKTLQELSIDGLLNRYILMAFQNSEYGD DSIKKAQNVINCFPKQWFMNLKGERTISQLENFCRYLVHLADTIYRNSIG CSDVEKRNARENIKQIVKLLASVRALDHAMSVASDH-------------- --N------------VKEFKSLIEGK-- >ENSCJAP00000017264 -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ---MF--------------------------------------------- ----------------------------------------RKARRVNVRK RNDSEEEE-------RER-------------------------------- -----------------------------------DEExx---------- ------------------------------xx------------------ -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- --------------x----------------------------------- -------------------------------------------------- -xx----------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- --------xx---------------------------------------- -------------------------------------------------- ----------------------------------------x--------- ----------xx-------------------------------------- -------------------------------------------------- ----------------xxxx-----xx----------------------- ---------------------------------------------xxx-- ------xxx----------------------------------------- -------------------------------------------------- -------------------------------------------------- -----x-------------------------------------------- ---------------xxExx------------------------------ ----------------------------------------------xxxx x-------------xPx--------------------------------- ---------------------------------xx-------------xx xxx----------------------------------------------- -------------------------------------------------- -------------------------------------------------- -----------------------------------------------xxx xxxxxxxGxxxxxxxxxRKRPRENKE--VP-------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ----------RAS-----------------------------------LL SF-QDE-EE-EN-------------------------------------- -----------------------------------------------E-- ------EVFKVKKSSYSKKIVKLLKKEYKE-------------------- --------------------------------DLEKSK------------ -------------------------------------------------- -------------------------------------------------- -IKTELN-----------S------------------------------- ---------SAESEQPLDKTGHVKDTNQEDGVIISEHGEDEMDMES---- EKEEE--------------------------------------------- ---------KPKT-GGAFS------------------------------- ---------------------------NALSSLNVLRP-----------G EIPDAAFIHAARKKRQMARELGDFTP-HDNE-PGKGRLVR-ED--ENDA- SD-DEDDDEKRRIVFSVKEKSQRQKIAEE--I---GIEGSDDDALV-TGE QDEELSRWEQEQIRKGINIPQVQASQPAEV-NMYYQNTYQTMPYGSSYGI PYSY--TAY-----------------------------GSS-DAKSQKTD NTVPFKTPSNEMTPVTIDLVKKQLKD-R---------------------- ------------------------------------------LDSMKELH KTNRQQHEKHLQSRVDSTRAIERLEGSSGGIGERYKFLQEMRGYVQDLLE CFSEKVPLINELESAIHQLYKQRASRLVQRRQDDIKDESSEFSSHS---- ---------------NKALMAPNLDSFGRDRALYQEHAK-RRIAERE--- ---ARR-TRR-RQAREQTGKMADHLEGLSSDDEETSTDITNFNLEK--DR ISKESSKVFEDVLESFYSIDCIKSQFEAWRSKYYTSYKDAYIGLCLPKLF NPLIRLQLLTWTPLE----------------------------------- -AKCRDFENMLWFESLLFYGCEERE--QEKDDVDVALLPTIVEKVILPKL TVIAENMWDPFSTT--------------QTSRMVGITLKLISGYPSVVNA ENKN-----TQVYLKALLLRMRRTLDDDVFMPLYPKNVLENKNSGPYLFF QRQFWSSVKLLGNFLQWYGIFSNKTLQELSIDGLLNRYILMAFQNSEYGD DSIKKAQNVINCFPKQWFMNLKGERTISQLENFCRYLVHLADTIYRNSIG CSDVEKRNARENIKQIVKLLASVRALDHAMSVASDH-------------- --N------------VKEFKSLIEGK-- >ENSCCAP00000006442 -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ---MF--------------------------------------------- ----------------------------------------RKARRVNVRK RNDSEEEE-------RER-------------------------------- -----------------------------------DEExx---------- ------------------------------xx------------------ -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- --------------x----------------------------------- -------------------------------------------------- -xx----------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- --------xx---------------------------------------- -------------------------------------------------- ----------------------------------------x--------- ----------xx-------------------------------------- -------------------------------------------------- ----------------xxxx-----xx----------------------- ---------------------------------------------xxx-- ------xxx----------------------------------------- -------------------------------------------------- -------------------------------------------------- -----x-------------------------------------------- ---------------xxExx------------------------------ ----------------------------------------------xxxx x-------------xPx--------------------------------- ---------------------------------xx-------------xx xxx----------------------------------------------- -------------------------------------------------- -------------------------------------------------- -----------------------------------------------xxx xxxxxxxGxxxxxxxxxRKRPRENKE--VP-------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ----------RAS-----------------------------------LL SF-QDE-EE-EN-------------------------------------- -----------------------------------------------E-- ------EVFKVKKSSYSKKIVKLLKKEYKE-------------------- --------------------------------DLEKSK------------ -------------------------------------------------- -------------------------------------------------- -IKTELN-----------S------------------------------- ---------SAESEQPLDKTGHVKDTNQEDGVIISEHGEDEMDMES---- EKEEE--------------------------------------------- ---------KPKA-GGAFS------------------------------- ---------------------------NALSSLNVLRP-----------G EIPDAAFIHAARKKRQMARELGDFTP-HDNE-PGKGRLVR-ED--ENDA- SD-DEDDDEKRRIVFSVKEKSQRQKIAEE--I---GIEGSDDDALV-TGE QDEELSRWEQEQIRKGINIPQVQASQPTEV-NMYYQNTYQTMPYGSSYGI PYSY--TAY-----------------------------GSS-DAKSQKTD NTVPFKTPSNEMTPVTIDLVKKQLKD-R---------------------- ------------------------------------------LDSMKELH KTNRQQHEKHLQSRVDSTRAIERLEGSSGGIGERYKFLQEMRGYVQDLLE CFSEKVPLINELESAIHQLYKQRASRLVQRRQDDIKDESSEFSSHS---- ---------------NKALMAPNLDSFGRDRALYQEHAK-RRIAERE--- ---ARR-TRR-RQAREQTGKMADHLEGLSSDDEETSTDITNFNLEK--DR ISKESSKVFEDVLESFYSIDCIKSQFEAWRSKYYTSYKDAYIGLCLPKLF NPLIRLQLLTWTPLE----------------------------------- -AKCRDFENMLWFESLLFYGCEERE--QEKDDVDVALLPTIVEKVILPKL TVIAENMWDPFSTT--------------QTSRMVGITLKLINGYPSVVNA ENKN-----TQVYLKALLLRMRRTLDDDVFMPLYPKNVLENKNSGPYLFF QRQFWSSVKLLGNFLQWYGIFSNKTLQELSIDGLLNRYILMAFQNSEYGD DSIKKAQNVINCFPKQWFMNLKGERTISQLENFCRYLVHLADTIYRNSIG CSDVEKRNARENIKQIVKLLASVRALDHAMSVASEH-------------- --N------------VKEFKSLIEGK-- >ENSANAP00000030801 -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ---MF--------------------------------------------- ----------------------------------------RKARRVNVRK RNDSEEEE-------RER-------------------------------- -----------------------------------DEExx---------- ------------------------------xx------------------ -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- --------------x----------------------------------- -------------------------------------------------- -xx----------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- --------xx---------------------------------------- -------------------------------------------------- ----------------------------------------x--------- ----------xx-------------------------------------- -------------------------------------------------- ----------------xxxx-----xx----------------------- ---------------------------------------------xxx-- ------xxx----------------------------------------- -------------------------------------------------- -------------------------------------------------- -----x-------------------------------------------- ---------------xxExx------------------------------ ----------------------------------------------xxxx x-------------xPx--------------------------------- ---------------------------------xx-------------xx xxx----------------------------------------------- -------------------------------------------------- -------------------------------------------------- -----------------------------------------------xxx xxxxxxxGxxxxxxxxxRKRPRENKE--VP-------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ----------RAS-----------------------------------LL SF-QDE-EE-EN-------------------------------------- -----------------------------------------------E-- ------EVFKVKKSSYSKKIVKLLKKEYKE-------------------- --------------------------------DLEKSK------------ -------------------------------------------------- -------------------------------------------------- -IKTELN-----------S------------------------------- ---------SAESEQPLDKTGHVKDTNQEDGVIISEHGEDEMDMES---- EKEEE--------------------------------------------- ---------KPKT-GGAFS------------------------------- ---------------------------NALSSLNVLRP-----------G EIPDAAFIHAARKKRQMARELGDFTP-HDNE-PGKGRLVR-ED--ENDA- SD-DEDDDEKRRIVFSVKEKSQRQKIAEE--I---GIEGSDDDALV-TGE QDEELSRWEQEQIRKGINIPQVQASQPAEV-NMYYQNTYQTMPYGSSYGI PYSY--TAY-----------------------------GSS-DAKSQKTD NTVPFKTPSNEMTPVTIDLVKKQLKD-R---------------------- ------------------------------------------LDSMKELH KTNRQQHEKHLQSRVDSTRAIERLEGSSGGIGERYKFLQEMRGYVQDLLE CFSEKVPLINELESAIHQLYKQRASRLVQRRQDDIKDESSEFSSHS---- ---------------NKALMAPNLDSFGRDRALYQEHAK-RRIAERE--- ---ARR-TRR-RQAREQTGKMADHLEGLSSDDEETSTDITNFNLEK--DR ISKESSKVFEDVLESFYSIDCIKSQFEAWRSKYYTSYKDAYIGLCLPKLF NPLIRLQLLTWTPLE----------------------------------- -AKCRDFENMLWFESLLFYGCEERE--QEKDDVDVALLPTIVEKVILPKL TVIAENMWDPFSTT--------------QTSRMVGITLKLINGYPSVVNA ENKN-----TQVYLKALLLRMRRTLDDDVFMPLYPKNVLENKNSGPYLFF QRQFWSSVKLLGNFLQWYGIFSNKTLQELSIDGLLNRYILMAFQNSEYGD DSIKKAQNVINCFPKQWFMNLKGERTISQLENFCRYLVHLADTIYRNSIG CSDVEKRNARENIKQIVKLLASVRALDHAMSVASDH-------------- --N------------VKEFKSLIEGK-- >ENSCATP00000012241 -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ---MF--------------------------------------------- ----------------------------------------RKARRVNVRK RNDSEEEE-------RER-------------------------------- -----------------------------------DEExx---------- ------------------------------xx------------------ -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- --------------x----------------------------------- -------------------------------------------------- -xx----------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- --------xx---------------------------------------- -------------------------------------------------- ----------------------------------------x--------- ----------xx-------------------------------------- -------------------------------------------------- ----------------xxxx-----xx----------------------- ---------------------------------------------xxx-- ------xxx----------------------------------------- -------------------------------------------------- -------------------------------------------------- -----x-------------------------------------------- ---------------xxExx------------------------------ ----------------------------------------------xxxx x-------------xPx--------------------------------- ---------------------------------xx-------------xx xxx----------------------------------------------- -------------------------------------------------- -------------------------------------------------- -----------------------------------------------xxx xxxxxxxGxxxxxxxxxRKRPRENKE--MP-------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ----------RAS-----------------------------------LL SF-QDE-EE-EN-------------------------------------- -----------------------------------------------E-- ------EVFKVKKSSYSKKIVKLLKKEYKE-------------------- --------------------------------DLEKSK------------ -------------------------------------------------- -------------------------------------------------- -IKTELN-----------S------------------------------- ---------SAESEQPLDKTGHVKDTNQEDGVIISEHGEDEMDMES---- EKEEE--------------------------------------------- ---------KPKT-GGAFS------------------------------- ---------------------------NALSSLNVLRP-----------G EIPDAAFIHAARKKRQMARELGDFTP-HDNE-PGKGRLVR-ED--ENDA- SD-DEDDDEKRRIVFSVKEKSQRQKIAEE--I---GIEGSDDDALV-TGE QDEELSRWEQEQIRKGINIPQVQASQPTEV-NMYYQNTYQTMPYSSSYGI PYSY--TAY-----------------------------GSS-DAKSQKTD NTVPFKTPSNEMTPVTIDLVKKQLKD-R---------------------- ------------------------------------------LDSMKELH KTNRQQHEKHLQSRVDSTRAIERLEGSSGGIGERYKFLQEMRGYVQDLLE CFSEKVPLINELESAIHQLYKQRASRLVQRRQDDIKDESSEFSSHS---- ---------------NKALMAPNLDSFGRDRALYQEHAK-RRIAERE--- ---ARR-TRR-RQAREQTGKMADHLEGLSSDDEETSTDITNFNLEK--DR ISKESSKVFEDVLESFYSIDCIKSQFEAWRSKYYTSYKDAYIGLCLPKLF NPLIRLQLLTWTPLE----------------------------------- -AKCRDFENMLWFESLLFYGCEERE--QEKDDVDVALLPTIVEKVILPKL TVIAENMWDPFSTT--------------QTSRMVGITLKLINGYPSVVNA ENKN-----TQVYLKALLLRMRRTLDDDVFMPLYPKNVLENKNSGPYLFF QRQFWSSVKLLGNFLQWYGIFSNKTLQELSIDGLLNRYILMAFQNSEYGD DSIKKAQNVINCFPKQWFMNLKGERTISQLENFCRYLVHLADTIYRNSIG CSDVEKRNARENIKQIVKLLASVRALDHAMSVASDH-------------- --N------------VKEFKSLIEGK-- >ENSMMUP00000016131 -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ---MF--------------------------------------------- ----------------------------------------RKARRVNVRK RNDSEEEE-------RER-------------------------------- -----------------------------------DEExx---------- ------------------------------xx------------------ -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- --------------x----------------------------------- -------------------------------------------------- -xx----------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- --------xx---------------------------------------- -------------------------------------------------- ----------------------------------------x--------- ----------xx-------------------------------------- -------------------------------------------------- ----------------xxxx-----xx----------------------- ---------------------------------------------xxx-- ------xxx----------------------------------------- -------------------------------------------------- -------------------------------------------------- -----x-------------------------------------------- ---------------xxExx------------------------------ ----------------------------------------------xxxx x-------------xPx--------------------------------- ---------------------------------xx-------------xx xxx----------------------------------------------- -------------------------------------------------- -------------------------------------------------- -----------------------------------------------xxx xxxxxxxGxxxxxxxxxRKRPRENKE--MP-------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ----------RAS-----------------------------------LL SF-QDE-EE-EN-------------------------------------- -----------------------------------------------E-- ------EVFKVKKSSYSKKIVKLLKKEYKE-------------------- --------------------------------DLEKSK------------ -------------------------------------------------- -------------------------------------------------- -IKTELN-----------S------------------------------- ---------SAESEQPLDKTGHVKDTNQEDGVIISEHGEDEMDMES---- EKEEE--------------------------------------------- ---------KPKT-GGAFS------------------------------- ---------------------------NALSSLNVLRP-----------G EIPDAAFIHAARKKRQMARELGDFTP-HDNE-PGKGRLVR-ED--ENDA- SD-DEDDDEKRRIVFSVKEKSQRQKIAEE--I---GIEGSDDDALV-TGE QDEELSRWEQEQIRKGINIPQVQASQPTEV-NMYYQNTYQTMPYSSSYGI PYSY--TAY-----------------------------GSS-DAKSQKTD NTVPFKTPSNEMTPVTIDLVKKQLKD-R---------------------- ------------------------------------------LDSMKELH KTNRQQHEKHLQSRVDSTRAIERLEGSSGGIGERYKFLQEMRGYVQDLLE CFSEKVPLINELESAIHQLYKQRASRLVQRRQDDIKDESSEFSSHS---- ---------------NKALMAPNLDSFGRDRALYQEHAK-RRIAERE--- ---ARR-TRR-RQAREQTGKMADHLEGLSSDDEETSTDITNFNLEK--DR ISKESSKVFEDVLESFYSIDCIKSQFEAWRSKYYTSYKDAYIGLCLPKLF NPLIRLQLLTWTPLE----------------------------------- -AKCRDFENMLWFESLLFYGCEERE--QEKDDVDVALLPTIVEKVILPKL TVIAENMWDPFSTT--------------QTSRMVGITLKLINGYPSVVNA ENKN-----TQVYLKALLLRMRRTLDDDVFMPLYPKNVLENKNSGPYLFF QRQFWSSVKLLGNFLQWYGIFSNKTLQELSIDGLLNRYILMAFQNSEYGD DSIKKAQNVINCFPKQWFMNLKGERTISQLENFCRYLVHLADTIYRNSIG CSDVEKRNARENIKQIVKLLASVRALDHAMSVASDH-------------- --N------------VKEFKSLIEGK-- >ENSMNEP00000015733 -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ---MF--------------------------------------------- ----------------------------------------RKARRVNVRK RNDSEEEE-------RER-------------------------------- -----------------------------------DEExx---------- ------------------------------xx------------------ -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- --------------x----------------------------------- -------------------------------------------------- -xx----------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- --------xx---------------------------------------- -------------------------------------------------- ----------------------------------------x--------- ----------xx-------------------------------------- -------------------------------------------------- ----------------xxxx-----xx----------------------- ---------------------------------------------xxx-- ------xxx----------------------------------------- -------------------------------------------------- -------------------------------------------------- -----x-------------------------------------------- ---------------xxExx------------------------------ ----------------------------------------------xxxx x-------------xPx--------------------------------- ---------------------------------xx-------------xx xxx----------------------------------------------- -------------------------------------------------- -------------------------------------------------- -----------------------------------------------xxx xxxxxxxGxxxxxxxxxRKRPRENKE--MP-------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ----------RAS-----------------------------------LL SF-QDE-EE-EN-------------------------------------- -----------------------------------------------E-- ------EVFKVKKSSYSKKIVKLLKKEYKE-------------------- --------------------------------DLEKSK------------ -------------------------------------------------- -------------------------------------------------- -IKTELN-----------S------------------------------- ---------SAESEQPLDKTGHVKDTNQEDGVIISEHGEDEMDMES---- EKEEE--------------------------------------------- ---------KPKT-GGAFS------------------------------- ---------------------------NALSSLNVLRP-----------G EIPDAAFIHAARKKRQMARELGDFTP-HDNE-PGKGRLVR-ED--ENDA- SD-DEDDDEKRRIVFSVKEKSQRQKIAEE--I---GIEGSDDDALV-TGE QDEELSRWEQEQIRKGINIPQVQASQPTEV-NMYYQNTYQTMPYSSSYGI PYSY--TAY-----------------------------GSS-DAKSQKTD NTVPFKTPSNEMTPVTIDLVKKQLKD-R---------------------- ------------------------------------------LDSMKELH KTNRQQHEKHLQSRVDSTRAIERLEGSSGGIGERYKFLQEMRGYVQDLLE CFSEKVPLINELESAIHQLYKQRASRLVQRRQDDIKDESSEFSSHS---- ---------------NKALMAPNLDSFGRDRALYQEHAK-RRIAERE--- ---ARR-TRR-RQAREQTGKMADHLEGLSSDDEETSTDITNFNLEK--DR ISKESSKVFEDVLESFYSIDCIKSQFEAWRSKYYTSYKDAYIGLCLPKLF NPLIRLQLLTWTPLE----------------------------------- -AKCRDFENMLWFESLLFYGCEERE--QEKDDVDVALLPTIVEKVILPKL TVIAENMWDPFSTT--------------QTSRMVGITLKLINGYPSVVNA ENKN-----TQVYLKALLLRMRRTLDDDVFMPLYPKNVLENKNSGPYLFF QRQFWSSVKLLGNFLQWYGIFSNKTLQELSIDGLLNRYILMAFQNSEYGD DSIKKAQNVINCFPKQWFMNLKGERTISQLENFCRYLVHLADTIYRNSIG CSDVEKRNARENIKQIVKLLASVRALDHAMSVASDH-------------- --N------------VKEFKSLIEGK-- >ENSTGEP00000033993 -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ---MF--------------------------------------------- ----------------------------------------RKARRVNVRK RNDSEEEE-------RER-------------------------------- -----------------------------------DEExx---------- ------------------------------xx------------------ -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- --------------x----------------------------------- -------------------------------------------------- -xx----------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- --------xx---------------------------------------- -------------------------------------------------- ----------------------------------------x--------- ----------xx-------------------------------------- -------------------------------------------------- ----------------xxxx-----xx----------------------- ---------------------------------------------xxx-- ------xxx----------------------------------------- -------------------------------------------------- -------------------------------------------------- -----x-------------------------------------------- ---------------xxExx------------------------------ ----------------------------------------------xxxx x-------------xPx--------------------------------- ---------------------------------xx-------------xx xxx----------------------------------------------- -------------------------------------------------- -------------------------------------------------- -----------------------------------------------xxx xxxxxxxGxxxxxxxxxRKRPRENKE--MP-------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ----------RAS-----------------------------------LL SF-QDE-EE-EN-------------------------------------- -----------------------------------------------E-- ------EVFKVKKSSYSKKIVKLLKKEYKE-------------------- --------------------------------DLEKSK------------ -------------------------------------------------- -------------------------------------------------- -IKTELN-----------S------------------------------- ---------SAESEQPLDKTGHVKDTNQEDGVIISEHGEDEMDMES---- EKEEE--------------------------------------------- ---------KPKT-GGAFS------------------------------- ---------------------------NALSSLNVLRP-----------G EIPDAAFIHAARKKRQMARELGDFTP-HDNE-PGKGRLVR-ED--ENDA- SD-DEDDDEKRRIVFSVKEKSQRQKIAEE--I---GIEGSDDDALV-TGE QDEELSRWEQEQIRKGINIPQVQASQPTEV-NMYYQNTYQTMPYSSSYGI PYSY--TAY-----------------------------GSS-DAKSQKTD NTVPFKTPSNEMTPVTIDLVKKQLKD-R---------------------- ------------------------------------------LDSMKELH KTNRQQHEKHLQSRVDSTRAIERLEGSSGGIGERYKFLQEMRGYVQDLLE CFSEKVPLINELESAIHQLYKQRASRLVQRRQDDIKDESSEFSSHS---- ---------------NKALMAPNLDSFGRDRALYQEHAK-RRIAERE--- ---ARR-TRR-RQAREQTGKMADHLEGLSSDDEETSTDITNFNLEK--DR ISKESSKVFEDVLESFYSIDCIKSQFEAWRSKYYTSYKDAYIGLCLPKLF NPLIRLQLLTWTPLE----------------------------------- -AKCRDFENMLWFESLLFYGCEERE--QEKDDVDVALLPTIVEKVILPKL TVIAENMWDPFSTT--------------QTSRMVGITLKLINGYPSVVNA ENKN-----TQVYLKALLLRMRRTLDDDVFMPLYPKNVLENKNSGPYLFF QRQFWSSVKLLGNFLQWYGIFSNKTLQELSIDGLLNRYILMAFQNSEYGD DSIKKAQNVINCFPKQWFMNLKGERTISQLENFCRYLVHLADTIYRNSIG CSDVEKRNARENIKQIVKLLASVRALDHAMSVASDH-------------- --N------------VKEFKSLIEGK-- >ENSMLEP00000018556 -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ---MF--------------------------------------------- ----------------------------------------RKARRVNVRK RNDSEEEE-------RER-------------------------------- -----------------------------------DEExx---------- ------------------------------xx------------------ -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- --------------x----------------------------------- -------------------------------------------------- -xx----------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- --------xx---------------------------------------- -------------------------------------------------- ----------------------------------------x--------- ----------xx-------------------------------------- -------------------------------------------------- ----------------xxxx-----xx----------------------- ---------------------------------------------xxx-- ------xxx----------------------------------------- -------------------------------------------------- -------------------------------------------------- -----x-------------------------------------------- ---------------xxExx------------------------------ ----------------------------------------------xxxx x-------------xPx--------------------------------- ---------------------------------xx-------------xx xxx----------------------------------------------- -------------------------------------------------- -------------------------------------------------- -----------------------------------------------xxx xxxxxxxGxxxxxxxxxRKRPRENKE--MP-------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ----------RAS-----------------------------------LL SF-QDE-EE-EN-------------------------------------- -----------------------------------------------E-- ------EVFKVKKSSYSKKIVKLLKKEYKE-------------------- --------------------------------DLEKSK------------ -------------------------------------------------- -------------------------------------------------- -IKTELN-----------S------------------------------- ---------SAESEQPLDKTGHVKDTNQEDGVIISEHGEDEMDMES---- EKEEE--------------------------------------------- ---------KPKT-GGAFS------------------------------- ---------------------------NALSSLNVLRP-----------G EIPDAAFIHAARKKRQMARELGDFTP-HDNE-PGKGRLVR-ED--ENDA- SD-DEDDDEKRRIVFSVKEKSQRQKIAEE--I---GIEGSDDDALV-TGE QDEELSRWEQEQIRKGINIPQVQASQPTEV-NMYYQNTYQTMPYSSSYGI PYSY--TAY-----------------------------GSS-DAKSQKTD NTVPFKTPSNEMTPVTIDLVKKQLKD-R---------------------- ------------------------------------------LDSMKELH KTNRQQHEKHLQSRVDSTRAIERLEGSSGGIGERYKFLQEMRGYVQDLLE CFSEKVPLINELESAIHQLYKQRASRLVQRRQDDIKDESSEFSSHS---- ---------------NKALMAPNLDSFGRDRALYQEHAK-RRIAERE--- ---ARR-TRR-RQAREQTGKMADHLEGLSSDDEETSTDITNFNLEK--DR ISKESSKVFEDVLESFYSIDCIKSQFEAWRSKYYTSYKDAYIGLCLPKLF NPLIRLQLLTWTPLE----------------------------------- -AKCRDFENMLWFESLLFYGCEERE--QEKDDVDVALLPTIVEKVILPKL TVIAENMWDPFSTT--------------QTSRMVGITLKLINGYPSVVNA ENKN-----TQVYLKALLLRMRRTLDDDVFMPLYPKNVLENKNSGPYLFF QRQFWSSVKLLGNFLQWYGIFSNKTLQELSIDGLLNRYILMAFQNSEYGD DSIKKAQNVINCFPKQWFMNLKGERTISQLENFCRYLVHLADTIYRNSIG CSDVEKRNARENIKQIVKLLASVRALDHAMSVASDH-------------- --N------------VKEFKSLIEGK-- >ENSMFAP00000032678 -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ---MF--------------------------------------------- ----------------------------------------RKARRVNVRK RNDSEEEE-------RER-------------------------------- -----------------------------------DEExx---------- ------------------------------xx------------------ -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- --------------x----------------------------------- -------------------------------------------------- -xx----------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- --------xx---------------------------------------- -------------------------------------------------- ----------------------------------------x--------- ----------xx-------------------------------------- -------------------------------------------------- ----------------xxxx-----xx----------------------- ---------------------------------------------xxx-- ------xxx----------------------------------------- -------------------------------------------------- -------------------------------------------------- -----x-------------------------------------------- ---------------xxExx------------------------------ ----------------------------------------------xxxx x-------------xPx--------------------------------- ---------------------------------xx-------------xx xxx----------------------------------------------- -------------------------------------------------- -------------------------------------------------- -----------------------------------------------xxx xxxxxxxGxxxxxxxxxRKRPRENKE--MP-------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ----------RAS-----------------------------------LL SF-QDE-EE-EN-------------------------------------- -----------------------------------------------E-- ------EVFKVKKSSYSKKIVKLLKKEYKE-------------------- --------------------------------DLEKSK------------ -------------------------------------------------- -------------------------------------------------- -IKTELN-----------S------------------------------- ---------SAESEQPLDKTGHVKDTNQEDGVIISEHGEDEMDMES---- EKEEE--------------------------------------------- ---------KPKT-GGAFS------------------------------- ---------------------------NALSSLNVLRP-----------G EIPDAAFIHAARKKRQMARELGDFTP-HDNE-PGKGRLVR-ED--ENDA- SD-DEDDDEKRRIVFSVKEKSQRQKIAEE--I---GIEGSDDDALV-TGE QDEELSRWEQEQIRKGINIPQVQASQPTEV-NMYYQNTYQTMPYSSSYGI PYSY--TAY-----------------------------GSS-DAKSQKTD NTVPFKTPSNEMTPVTIDLVKKQLKD-R---------------------- ------------------------------------------LDSMKELH KTNRQQHEKHLQSRVDSTRAIERLEGSSGGIGERYKFLQEMRGYVQDLLE CFSEKVPLINELESAIHQLYKQRASRLVQRRQDDIKDESSEFSSHS---- ---------------NKALMAPNLDSFGRDRALYQEHAK-RRIAERE--- ---ARR-TRR-RQAREQTGKMADHLEGLSSDDEETSTDITNFNLEK--DR ISKESSKVFEDVLESFYSIDCIKSQFEAWRSKYYTSYKDAYIGLCLPKLF NPLIRLQLLTWTPLE----------------------------------- -AKCRDFENMLWFESLLFYGCEERE--QEKDDVDVALLPTIVEKVILPKL TVIAENMWDPFSTT--------------QTSRMVGITLKLINGYPSVVNA ENKN-----TQVYLKALLLRMRRTLDDDVFMPLYPKNVLENKNSGPYLFF QRQFWSSVKLLGNFLQWYGIFSNKTLQELSIDGLLNRYILMAFQNSEYGD DSIKKAQNVINCFPKQWFMNLKGERTISQLENFCRYLVHLADTIYRNSIG CSDVEKRNARENIKQIVKLLASVRALDHAMSVASDH-------------- --N------------VKEFKSLIEGK-- >ENSPANP00000010252 -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ---MF--------------------------------------------- ----------------------------------------RKARRVNVRK RNDSEEEE-------RER-------------------------------- -----------------------------------DEExx---------- ------------------------------xx------------------ -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- --------------x----------------------------------- -------------------------------------------------- -xx----------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- --------xx---------------------------------------- -------------------------------------------------- ----------------------------------------x--------- ----------xx-------------------------------------- -------------------------------------------------- ----------------xxxx-----xx----------------------- ---------------------------------------------xxx-- ------xxx----------------------------------------- -------------------------------------------------- -------------------------------------------------- -----x-------------------------------------------- ---------------xxExx------------------------------ ----------------------------------------------xxxx x-------------xPx--------------------------------- ---------------------------------xx-------------xx xxx----------------------------------------------- -------------------------------------------------- -------------------------------------------------- -----------------------------------------------xxx xxxxxxxGxxxxxxxxxRKRPRENKE--MP-------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ----------RAS-----------------------------------LL SF-QDE-EE-EN-------------------------------------- -----------------------------------------------E-- ------EVFKVKKSSYSKKIVKLLKKEYKE-------------------- --------------------------------DLEKSK------------ -------------------------------------------------- -------------------------------------------------- -IKTELN-----------S------------------------------- ---------SAESEQPLDKTGHVKDTNQEDGVIISEHGEDEMDMES---- EKEEE--------------------------------------------- ---------KPKT-GGAFS------------------------------- ---------------------------NALSSLNVLRP-----------G EIPDAAFIHAARKKRQMARELGDFTP-HDNE-PGKGRLVR-ED--ENDA- SD-DEDDDEKRRIVFSVKEKSQRQKIAEE--I---GIEGSDDDALV-TGE QDEELSRWEQEQIRKGINIPQVQASQPTEV-NMYYQNTYQTMPYSSSYGI PYSY--TAY-----------------------------GSS-DAKSQKTD NTVPFKTPSNEMTPVTIDLVKKQLKD-R---------------------- ------------------------------------------LDSMKELH KTNRQQHEKHLQSRVDSTRAIERLEGSSGGIGERYKFLQEMRGYVQDLLE CFSEKVPLINELESAIHQLYKQRASRLVQRRQDDIKDESSEFSSHS---- ---------------NKALMAPNLDSFGRDRALYQEHAK-RRIAERE--- ---ARR-TRR-RQAREQTGKMADHLEGLSSDDEETSTDITNFNLEK--DR ISKESSKVFEDVLESFYSIDCIKSQFEAWRSKYYTSYKDAYIGLCLPKLF NPLIRLQLLTWTPLE----------------------------------- -AKCRDFENMLWFESLLFYGCEERE--QEKDDVDVALLPTIVEKVILPKL TVIAENMWDPFSTT--------------QTSRMVGITLKLINGYPSVVNA ENKN-----TQVYLKALLLRMRRTLDDDVFMPLYPKNVLENKNSGPYLFF QRQFWSSVKLLGNFLQWYGIFSNKTLQELSIDGLLNRYILMAFQNSEYGD DSIKKAQNVINCFPKQWFMNLKGERTISQLENFCRYLVHLADTIYRNSIG CSDVEKRNARENIKQIVKLLASVRALDHAMSVASDH-------------- --N------------VKEFKSLIEGK-- >ENSCSAP00000005914 -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ---MF--------------------------------------------- ----------------------------------------RKARRVNVRK RNDSEEEE-------RER-------------------------------- -----------------------------------DEExx---------- ------------------------------xx------------------ -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- --------------x----------------------------------- -------------------------------------------------- -xx----------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- --------xx---------------------------------------- -------------------------------------------------- ----------------------------------------x--------- ----------xx-------------------------------------- -------------------------------------------------- ----------------xxxx-----xx----------------------- ---------------------------------------------xxx-- ------xxx----------------------------------------- -------------------------------------------------- -------------------------------------------------- -----x-------------------------------------------- ---------------xxExx------------------------------ ----------------------------------------------xxxx x-------------xPx--------------------------------- ---------------------------------xx-------------xx xxx----------------------------------------------- -------------------------------------------------- -------------------------------------------------- -----------------------------------------------xxx xxxxxxxGxxxxxxxxxRKRPRENKE--MP-------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ----------RAS-----------------------------------LL SF-QDE-EE-EN-------------------------------------- -----------------------------------------------E-- ------EVFKVKKSSYSKKIVKLLKKEYKE-------------------- --------------------------------DLEKSK------------ -------------------------------------------------- -------------------------------------------------- -IKTELN-----------S------------------------------- ---------SAESEQPLDKTGHIKDTNQEDGVIISEHGEDEMDMES---- EKEEE--------------------------------------------- ---------KPKT-GGAFS------------------------------- ---------------------------NALSSLNVLRP-----------G EIPDAAFIHAARKKRQMARELGDFTP-HDNE-PGKGRLVR-ED--ENDA- SD-DEDDDEKRRIVFSVKEKSQRQKIAEE--I---GIEGSDDDALV-TGE QDEELSRWEQEQIRKGINIPQVQASQPTEV-NMYYQNTYQTMPYSSSYGI PYSY--TAY-----------------------------GSS-DAKSQKTD NTVPFKTPSNEMTPVTIDLVKKQLKD-R---------------------- ------------------------------------------LDSMKELH KTNRQQHEKHLQSRVDSTRAIERLEGSSGGIGERYKFLQEMRGYVQDLLE CFSEKVPLINELESAIHQLYKQRASRLVQRRQDDIKDESSEFSSHS---- ---------------NKALMAPNLDSFGRDRALYQEHAK-RRIAERE--- ---ARR-TRR-RQAREQTGKMADHLEGLSSDDEETSTDITNFNLEK--DR ISKESSKVFEDVLESFYSIDCIKSQFEAWRSKYYTSYKDAYIGLCLPKLF NPLIRLQLLTWTPLE----------------------------------- -AKCRDFENMLWFESLLFYGCEERE--QEKDDVDVALLPTIVEKVILPKL TVIAENMWDPFSTT--------------QTSRMVGITLKLINGYPSVVNA ENKN-----TQVYLKALLLRMRRTLDDDVFMPLYPKNVLENKNSGPYLFF QRQFWSSVKLLGNFLQWYGIFSNKTLQELSIDGLLNRYILMAFQNSEYGD DSIKKAQNVINCFPKQWFMNLKGERTISQLENFCRYLVHLADTIYRNSIG CSDVEKRNARENIKQIVKLLASVRALDHAMSVASDH-------------- --N------------VKEFKSLIEGK-- >ENSRROP00000001103 -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ---MF--------------------------------------------- ----------------------------------------RKARRVNVRK RNDSEEEE-------RER-------------------------------- -----------------------------------DEExx---------- ------------------------------xx------------------ -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- --------------x----------------------------------- -------------------------------------------------- -xx----------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- --------xx---------------------------------------- -------------------------------------------------- ----------------------------------------x--------- ----------xx-------------------------------------- -------------------------------------------------- ----------------xxxx-----xxx---------------------- ---------------------------------------------xxx-- ------xxx----------------------------------------- -------------------------------------------------- -------------------------------------------------- -----x-------------------------------------------- ---------------xxExx------------------------------ ----------------------------------------------xxxx x-------------xPx--------------------------------- ---------------------------------xx-------------xx xxx----------------------------------------------- -------------------------------------------------- -------------------------------------------------- -----------------------------------------------xxx xxxxxxxGxxxxxxxxxRKRPRENKE--MP-------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ----------RAS-----------------------------------LL SF-QDE-EE-EN-------------------------------------- -----------------------------------------------E-- ------EVFKVKKSSYSKKIVKLLKKEYKE-------------------- --------------------------------DLEKSK------------ -------------------------------------------------- -------------------------------------------------- -IKTELN-----------S------------------------------- ---------SAESEQPLDKAGHVKDTNQEDGVIISEHGEDEMDMES---- EKEEE--------------------------------------------- ---------KPKT-GGAFS------------------------------- ---------------------------NALSSLNVLRP-----------G EIPDAAFIHAARKKRQMARELGDFTP-HDNE-PGKGRLVR-ED--ENDA- SD-DEDDDEKRRIVFSVKEKSQRQKIAEE--I---GIEGSDDDALV-TGE QDEELSRWEQEQIRKGINIPQVQASQPTEV-NMYYQNTYQTMPYSSSYGI PYSY--TAY-----------------------------GSS-DAKSQKTD NTVPFKTPSNEMTPVTIDLVKKQLKD-R---------------------- ------------------------------------------LDSMKELH KTNRQQHEKHLQSRVDSTRAIERLEGSSGGIGERYKFLQEMRGYVQDLLE CFSEKVPLINELESAIHQLYKQRASRLVQRRQDDIKDESSEFSSHS---- ---------------NKALMAPNLDSFGRDRALYQEHAK-RRIAERE--- ---ARR-TRR-RQAREQTGKMADHLEGLSSDDEETSTDITNFNLEK--DR ISKESSKVFEDVLESFYSIDCIKSQFEAWRSKYYTSYKDAYIGLCLPKLF NPLIRLQLLTWTPLE----------------------------------- -AKCRDFENMLWFESLLFYGCEERE--QEKDDVDVALLPTIVEKVILPKL TVIAENMWDPFSTT--------------QTSRMVGITLKLINGYPSVVNA ENKN-----TQVYLKALLLRMRRTLDDDVFMPLYPKNVLENKNSGPYLFF QRQFWSSVKLLGNFLQWYGIFSNKTLQELSIDGLLNRYILMAFQNSEYGD DSIKKAQNVINCFPKQWFMNLKGERTISQLENFCRYLVHLADTIYRNSIG CSDVEKRNARENIKQIVKLLASVRALDHAMSVASDH-------------- --N------------VKEFKSLIEGK-- >ENSCANP00000033996 -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ---MF--------------------------------------------- ----------------------------------------RKARRVNVRK RNDSEEEE-------RER-------------------------------- -----------------------------------DEExx---------- ------------------------------xx------------------ -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- --------------x----------------------------------- -------------------------------------------------- -xx----------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- --------xx---------------------------------------- -------------------------------------------------- ----------------------------------------x--------- ----------xxxxxxxxxxxxxxxxxx---------xxx---------- ---------------xxx-------------------------------- xxxxxxx-------xx---------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -xx----------------------------------------------- -------------------------------------------------- -------------------------------------------------- -----------------------------------------------xxx xxxxxxxGxxxxxxxxxRKRPRENKE--MP-------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ----------RAS-----------------------------------LL SF-QDE-EE-EN-------------------------------------- -----------------------------------------------E-- ------EVFKVKKSSYSKKIVKLLKKEYKE-------------------- --------------------------------DLEKSK------------ -------------------------------------------------- -------------------------------------------------- -IKTELN-----------S------------------------------- ---------SAESEQPLDKAGHVKDTNQEDGVIISEHGEDEMDMES---- EKEEE--------------------------------------------- ---------KPKT-GGAFS------------------------------- ---------------------------NALSSLNVLRP-----------G EIPDAAFIHAARKKRQMARELGDFTP-HDNE-PGKGRLVR-ED--ENDA- SD-DEDDDEKRRIVFSVKEKSQRQKIAEE--I---GIEGSDDDALV-TGE QDEELSRWEQEQIRKGINIPQVQASQPTEV-NMYYQNTYQTMPYSSSYGI PYSY--TAY-----------------------------GSS-DAKSQKTD NTVPFKTPSNEMTPVTIDLVKKQLKD-R---------------------- ------------------------------------------LDSMKELH KTNRQQHEKHLQSRVDSTRAIERLEGSSGGIGERYKFLQEMRGYVQDLLE CFSEKVPLINELESAIHQLYKQRASRLVQRRQDDIKDESSEFSSHS---- ---------------NKALMAPNLDSFGRDRALYQEHAK-RRIAERE--- ---ARR-TRR-RQAREQTGKMADHLEGLSSDDEETSTDITNFNLEK--DR ISKESSKVFEDVLESFYSIDCIKSQFEAWRSKYYTSYKDAYIGLCLPKLF NPLIRLQLLTWTPLE----------------------------------- -AKCRDFENMLWFESLLFYGCEERE--QEKDDVDVALLPTIVEKVILPKL TVIAENMWDPFSTT--------------QTSRMVGITLKLINGYPSVVNA ENKN-----TQVYLKALLLRMRRTLDDDVFMPLYPKNVLENKNSGPYLFF QRQFWSSVKLLGNFLQWYGIFSNKTLQELSIDGLLNRYILMAFQNSEYGD DSIKKAQNVINCFPKQWFMNLKGERTISQLENFCRYLVHLADTIYRNSIG CSDVEKRNARENIKQIVKLLASVRALDHAMSVASDH-------------- --N------------VKEFKSLIEGK-- >ENSPTEP00000009733 -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ---MF--------------------------------------------- ----------------------------------------RKARRVNVRK RNDSEEEE-------RER-------------------------------- -----------------------------------DEExx---------- ------------------------------xx------------------ -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- --------------x----------------------------------- -------------------------------------------------- -xx----------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- --------xx---------------------------------------- -------------------------------------------------- ----------------------------------------x--------- ----------xx-------------------------------------- -------------------------------------------------- ----------------xxxx-----xx----------------------- ---------------------------------------------xxxx- ---xxxxxx----------------------------------------- -------------------------------------------------- -------------------------------------------------- -----x-------------------------------------------- ---------------xxExx------------------------------ ----------------------------------------------xxxx x-------------xPx--------------------------------- ---------------------------------xx-------------xx xxx----------------------------------------------- -------------------------------------------------- -------------------------------------------------- -----------------------------------------------xxx xxxxxxxGxxxxxxxxxRKRPRENKE--MP-------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ----------RAS-----------------------------------LL SF-QDE-EE-EN-------------------------------------- -----------------------------------------------E-- ------EVFKVKKSSYSKKIVKLLKKEYKE-------------------- --------------------------------DLEKSK------------ -------------------------------------------------- -------------------------------------------------- -IKTELN-----------S------------------------------- ---------SAESEQPLDKAGHVKDTNQEDGVIISEHGEDEMDMES---- EKEEE--------------------------------------------- ---------KPKT-GGAFS------------------------------- ---------------------------NALSSLNVLRP-----------G EIPDAAFIHAARKKRQMARELGDFTP-HDNE-PGKGRLVR-ED--ENDA- SD-DEDDDEKRRIVFSVKEKSQRQKIAEE--I---GIEGSDDDALV-TGE QDEELSRWEQEQIRKGINIPQVQASQPTEV-NMYYQNTYQTMPYSSSYGI PYSY--TAY-----------------------------GSS-DAKSQKTD NTVPFKTPSNEMTPVTIDLVKKQLKD-R---------------------- ------------------------------------------LDSMKELH KTNRQQHEKHLQSRVDSTRAIERLEGSSGGIGERYKFLQEMRGYVQDLLE CFSEKVPLINELESAIHQLYKQRASRLVQRRQDDIKDESSEFSSHS---- ---------------NKALMAPNLDSFGRDRALYQEHAK-RRIAERE--- ---ARR-TRR-RQAREQTGKMADHLEGLSSDDEETSTDITNFNLEK--DR ISKESSKVFEDVLESFYSIDCIKSQFEAWRSKYYTSYKDAYIGLCLPKLF NPLIRLQLLTWTPLE----------------------------------- -AKCRDFENMLWFESLLFYGCEERE--QEKDDVDVALLPTIVEKVILPKL TVIAENMWDPFSTT--------------QTSRMVGITLKLINGYPSVVNA ENKN-----TQVYLKALLLRMRRTLDDDVFMPLYPKNVLENKNSGPYLFF QRQFWSSVKLLGNFLQWYGIFSNKTLQELSIDGLLNRYILMAFQNSEYGD DSIKKAQNVINCFPKQWFMNLKGERTISQLENFCRYLVHLADTIYRNSIG CSDVEKRNARENIKQIVKLLASVRALDHAMSVASDH-------------- --N------------VKEVKSLIEGK-- >ENSNLEP00000004596 -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ---MF--------------------------------------------- ----------------------------------------RKARRVNVRK RNDSEEEE-------RER-------------------------------- -----------------------------------DEExx---------- ------------------------------xx------------------ -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- --------------x----------------------------------- -------------------------------------------------- -xx----------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- --------xx---------------------------------------- -------------------------------------------------- ----------------------------------------x--------- ----------xx-------------------------------------- -------------------------------------------------- ----------------xxxx-----xx----------------------- ---------------------------------------------xxx-- ------xxx----------------------------------------- -------------------------------------------------- -------------------------------------------------- -----x-------------------------------------------- ---------------xxExx------------------------------ ----------------------------------------------xxxx x-------------xPx--------------------------------- ---------------------------------xx-------------xx xxx----------------------------------------------- -------------------------------------------------- -------------------------------------------------- -----------------------------------------------xxx xxxxxxxGxxxxxxxxxRKRPRENKE--VP-------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ----------RAS-----------------------------------LL SF-QDE-EE-EN-------------------------------------- -----------------------------------------------E-- ------EVFKVKKSSYSKKIVKLLKKEYKE-------------------- --------------------------------DLEKSK------------ -------------------------------------------------- -------------------------------------------------- -IKTELN-----------S------------------------------- ---------SAESEQPLDKTGQVKDTNQEDGVIISEHGEDEMDMES---- EKEEE--------------------------------------------- ---------KPKT-GGAFS------------------------------- ---------------------------NALSSLNVLRP-----------G EIPDAAFIHAARKKRQMARELGDFTP-HDNE-PGKGRLVR-ED--ENDA- SD-DEDDDEKRRIVFSVKEKSQRQKIAEE--I---GIEGSDDDALV-TGE QDEELSRWEQEQIRKGINIPQVQASQPAEV-NMYYQNTYQTMPYGSSYGI PYSY--TAY-----------------------------GSS-DAKSQKTD NTVPFKTPSNEMTPVTIDLVKKQLKD-R---------------------- ------------------------------------------LDSMKELH KTNRQQHEKHLQSRVDSTRAIERLEGSSGGIGERYKFLQEMRGYVQDLLE CFSEKVPLINELESAIHQLYKQRASRLVQRRQDDIKDESSEFSSHS---- ---------------NKALMAPNLDSFGRDRALYQEHAK-RRIAERE--- ---ARR-TRR-RQAREQTGKMADHLEGLSSDDEETSTDITNFNLEK--DR ISKESSKVFEDVLESFYSIDCIKSQFEAWRSKYYFSYKDAYIGLCLPKLF NPLILLQLLTWTPLE----------------------------------- -AKCRDFENMLWFESLLFYGCEERE--QEKDDVDVALLPTIVEKVILPKL TVIAENMWDPFSTT--------------QTSRMVGITLKLINGYPSVVNA ENKN-----TQVYLKALLLRMRRTLDDDVFMPLYPKNVLENKNSGPYLFF QRQFWSSVKLLGNFLQWYGIFSNKTLQELSIDGLLNRYILMAFQNSEYGD DSIKKAQNVINCFPKQWFMNLKGERTISQLENFCRYLVHLADTIYRNSIG CSDVEKRNARENIKQIVKLLASVRALDHAMSVASDH-------------- --N------------VKEFKSLIEGK-- >ENSOGAP00000002985 -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ---MF--------------------------------------------- ----------------------------------------RKARRVNVRK RNDSEEEE-------RER-------------------------------- -----------------------------------DEExx---------- ------------------------------xx------------------ -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- --------------x----------------------------------- -------------------------------------------------- -xx----------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ---------x---------------------------------------- -------------------------------------------------- ----------------------------------------x--------- ----------xx-------------------------------------- -------------------------------------------------- ----------------xxxxx---xxx----------------------- ---------------------------------------------xxx-- ------xxx----------------------------------------- -------------------------------------------------- -------------------------------------------------- -----x-------------------------------------------- ---------------xxExx------------------------------ ----------------------------------------------xxxx x-------------xPx--------------------------------- ---------------------------------xx-------------xx xxx----------------------------------------------- -------------------------------------------------- -------------------------------------------------- -----------------------------------------------xxx xxxxxxxGxxxxxxxxxRKRPRENKE--VP-------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ----------RAS-----------------------------------LL SF-QDE-EE-EN-------------------------------------- -----------------------------------------------E-- ------EVFKVKKSSYSKKIVKLLKKEYKE-------------------- --------------------------------DLEKSK------------ -------------------------------------------------- -------------------------------------------------- -IKTELN-----------S------------------------------- ---------SADNEQPLDKTGHVKDTNQEDGVIISEHGEDEMDMES---- EKEEE--------------------------------------------- ---------KPKA-GGAFS------------------------------- ---------------------------NALSSLNVLRP-----------G EIPDAAFIHAARKKRQMARELGDFTP-HDNE-PGKGRLVR-ED--ENDA- SD-DEDDDEKRRIVFSVKEKSQRQKIAEE--I---GIEGSDDDALV-TGE QDEELSRWEQEQIRKGINIPQVQASQPAEV-NMYYPNTYQTMPYGSSYGI PYSY--TAY-----------------------------GSS-DAKSQKTD NTVPFKTPSNEMTPVTIDLVKKQLKD-R---------------------- ------------------------------------------LDSMKELH KTNRQQHEKHLQSRVDSTRAIERLEGSSGGIGERYKFLQEMRGYVQDLLE CFSEKVPLINELESAIHQLYKQRASRLVQRRQDDIKDESSEFSSHS---- ---------------NKALMAPNLDSFGRDRALYQEHAK-RRIAERE--- ---ARR-TRR-RQAREQTGKMADHLEGLSSDDEETSTDITNFNLEK--DR ISKESSKVFEDVLESFYSIDCIKSQFEAWRSKYYMSYKDAYIGLCLPKLF NPLIRLQLLTWTPLE----------------------------------- -AKCRDFENMLWFESLLFYGCEERE--QEKDDVDVALLPTIVEKVILPKL TVIAENMWDPFSTT--------------QTSRMVGITLKLINGYPSVVNA ENKN-----TQVYLKALLLRMRRTLDDDVFMPLYPKNVLENKNSGPYLFF QRQFWSSVKLLGNFLQWYGIFSNKTLQELSIDGLLNRYILMAFQNSEYGD DSIKKAQNVINCFPKQWFMNLKGERTISQLENFCRYLVHLADTIYRNSIG CSDVEKRNARENIKQIVKLLASVRALDHAMAVASDH-------------- --N------------VKEFKSLIEGK-- >ENSSTOP00000012612 -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ---MF--------------------------------------------- ----------------------------------------RKARRVN--- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ---xxxxGxxxxxxxxxRKRPRENKE--VP-------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ----------RAS-----------------------------------LL SF-QDE-EE-EN-------------------------------------- -----------------------------------------------E-- ------EVFKVKKSSYSKKIVKLLKKEYKE-------------------- --------------------------------DLEKSK------------ -------------------------------------------------- -------------------------------------------------- -IKTELN-----------S------------------------------- ---------SADNEQPLDKTGHVKDTNPEDGVIISEHGEDEMDMES---- EKEEE--------------------------------------------- ---------KPKA-GGTFS------------------------------- ---------------------------NALSSLNVLRP-----------G EIPDAAFIHAARKKRQMARELGDFTP-HDNE-PGKGRLVR-ED--ENDA- SD-DEDDDEKRRIVFSVKEKSQRQKIAEE--I---GIEGSDDDALV-TGE QDEELSRWEQEQIRKGINIPQVQASQPTEV-NMYYQNTYQAMPYGSSYGI PYSY--TTY-----------------------------GSS-DAKSQKTD NSAPFKTPSNEMTPVTIDLVKKQLKD-R---------------------- ------------------------------------------LDSMKELH KTNRQQHEKHLQSRVDSTRAIERLEGSSGGIGERYKFLQEMRGYVQDLLE CFSEKVPLINELESAIHQLYKQRASRLVQRRQDDIKDESSEFSSHS---- ---------------NKALMAPNLDSFGRDRALYQEHAK-RRIAERE--- ---ARR-TRR-RQAREQTGKMADHLEGLSSDDEETSTDITNFNLEK--DR ISKESSKVFEDVLESFYSIDCIKSQFEAWRSKYYMSYKDAYIGLCLPKLF NPLIRLQLLTWTPLE----------------------------------- -AKCRDFENMLWFESLLFYGCEERE--QEKDDVDVALLPTIVEKVILPKL TVIAENMWDPFSTT--------------QTSRMVGITLKLINGYPSVVNA ENKN-----TQVYLKALLLRMRRTLDDDVFMPLYPKNVLENKNSGPYLFF QRQFWSSVKLLGNFLQWYGIFSNKTLQELSIDGLLNRYILMAFQNSEYGD DSIKKAQNVINCFPKQWFMNLKGERTISQLENFCRYLVHLADTIYRNSIG CSDVDKRNARENIKQIVKLLASIRALDHAMSVASDH-------------- --N------------VKEFKSLIEGK-- >ENSUPAP00010002295 -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ---MF--------------------------------------------- ----------------------------------------RKARRVNVRK RNDSEEEE-------RER-------------------------------- -----------------------------------DEExx---------- ------------------------------xx------------------ -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- --------------x----------------------------------- -------------------------------------------------- -xx----------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- --------xx---------------------------------------- -------------------------------------------------- ----------------------------------------x--------- ----------xx-------------------------------------- -------------------------------------------------- ----------------xxxx-----xx----------------------- ---------------------------------------------xxx-- ------xxx----------------------------------------- -------------------------------------------------- -------------------------------------------------- -----x-------------------------------------------- ---------------xxExx------------------------------ ----------------------------------------------xxxx x-------------xPx--------------------------------- ---------------------------------xx-------------xx xxx----------------------------------------------- -------------------------------------------------- -------------------------------------------------- -----------------------------------------------xxx xxxxxxxGxxxxxxxxxRKRPRENKE--VP-------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ----------RAS-----------------------------------LL SF-QDE-EE-EN-------------------------------------- -----------------------------------------------E-- ------EVFKVKKSSYSKKIVKLLKKEYKE-------------------- --------------------------------DLEKSK------------ -------------------------------------------------- -------------------------------------------------- -IKTELN-----------S------------------------------- ---------SADNEQPLDKTGHVKDINPEDGVIISEHGEDEMDMES---- EKEEE--------------------------------------------- ---------KPKA-GGTFS------------------------------- ---------------------------NALSSLNVLRP-----------G EIPDAAFIHAARKKRQMARELGDFTP-HDNE-PGKGRLVR-ED--ENDA- SD-DEDDDEKRRIVFSVKEKSQRQKIAEE--I---GIEGSDDDALV-TGE QDEELSRWEQEQIRKGINIPQVQASQPTEV-NMYYQNTYQAMPYGSSYGI PYSY--TAY-----------------------------GSS-DAKSQKTD NSAPFKTPSNEMTPVTIDLVKKQLKD-R---------------------- ------------------------------------------LDSMKELH KTNRQQHEKHLQSRVDSTRAIERLEGSSGGIGERYKFLQEMRGYVQDLLE CFSEKVPLINELESAIHQLYKQRASRLVQRRQDDIKDESSEFSSHS---- ---------------NKALMAPNLDSFGRDRALYQEHAK-RRIAERE--- ---ARR-TRR-RQAREQTGKMADHLEGLSSDDEETSTDITNFNLEK--DR ISKESSKVFEDVLESFYSIDCIKSQFEAWRSKYYMSYKDAYIGLCLPKLF NPLIRLQLLTWTPLE----------------------------------- -AKCRDFENMLWFESLLFYGCEERE--QEKDDVDVALLPTIVEKVILPKL TVIAENMWDPFSTT--------------QTSRMVGITLKLINGYPSVVNA ENKN-----TQVYLKALLLRMRRTLDDDVFMPLYPKNVLENKNSGPYLFF QRQFWSSVKLLGNFLQWYGIFSNKTLQELSIDGLLNRYILMAFQNSEYGD DSIKKAQNVINCFPKQWFMNLKGERTISQLENFCRYLVHLADTIYRNSIG CSDVDKRNARENIKQIVKLLASIRALDHAMSVASDH-------------- --N------------VKEFKSLIEGK-- >ENSMMMP00000000789 -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ---MF--------------------------------------------- ----------------------------------------RKARRVNVRK RNDSEEEE-------RER-------------------------------- -----------------------------------DEExx---------- ------------------------------xx------------------ -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- --------------x----------------------------------- -------------------------------------------------- -xx----------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- --------xx---------------------------------------- -------------------------------------------------- ----------------------------------------x--------- ----------xx-------------------------------------- -------------------------------------------------- ----------------xxxx-----xx----------------------- ---------------------------------------------xxx-- ------xxx----------------------------------------- -------------------------------------------------- -------------------------------------------------- -----x-------------------------------------------- ---------------xxExxxxxx-------------------------- --------------------xxx----------------------x---- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ----------------------ENKE--VP-------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ----------RAS-----------------------------------LL SF-QDE-EE-EN-------------------------------------- -----------------------------------------------E-- ------EVFKVKKSSYSKKIVKLLKKEYKE-------------------- --------------------------------DLEKSK------------ -------------------------------------------------- -------------------------------------------------- -IKTELN-----------S------------------------------- ---------SADNEQPLDKTGHVKDTNPEDGVIISEHGEDEMDMES---- EKEEE--------------------------------------------- ---------KPKA-GGTFS------------------------------- ---------------------------NALSSLNVLRP-----------G EIPDAAFIHAARKKRQMARELGDFTP-HDNE-PGKGRLVR-ED--ENDA- SD-DEDDDEKRRIVFSVKEKSQRQKIAEE--I---GIEGSDDDALV-TGE QDEELSRWEQEQIRKGINIPQVQASQPTEV-NMYYQNTYQAMPYGSSYGI PYSY--TAY-----------------------------GSS-DAKSQKTD NSAPFKTPSNEMTPVTIDLVKKQLKD-R---------------------- ------------------------------------------LDSMKELH KTNRQQHEKHLQSRVDSTRAIERLEGSSGGIGERYKFLQEMRGYVQDLLE CFSEKVPLINELESAIHQLYKQRASRLVQRRQDDIKDESSEFSSHS---- ---------------NKALMAPNLDSFGRDRALYQEHAK-RRIAERE--- ---ARR-TRR-RQAREQTGKMADHLEGLSSDDEETSTDITNFNLEK--DR ISKESSKVFEDVLESFYSIDCIKSQFEAWRSKYYMSYKDAYIGLCLPKLF NPLIRLQLLTWTPLE----------------------------------- -AKCRDFENMLWFESLLFYGCEERE--QEKDDVDVALLPTIVEKVILPKL TVIAENMWDPFSTT--------------QTSRMVGITLKLINGYPSVVNA ENKN-----TQVYLKALLLRMRRTLDDDVFMPLYPKNVLENKNSGPYLFF QRQFWSSVKLLGNFLQWYGIFSNKTLQELSIDGLLNRYILMAFQNSEYGD DSIKKAQNVISCFPKQWFMNLKGERTISQLENFCRYLVHLADTIYRNSIG CSDVDKRNARENIKQIVKLLASIRALDHAMSVASDH-------------- --N------------VKEFKSLIEGK-- >ENSSDAP00000010431 -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ---MF--------------------------------------------- ----------------------------------------RKARRVNVRK RNDSEEEE-------RE--------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ---------xxxxxxxxRKRPRENKE--EP-------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ----------RAS-----------------------------------LL SF-QDE-EE-EN-------------------------------------- -----------------------------------------------E-- ------EVFKVKKSSYSKKIVKLLKKEYKE-------------------- --------------------------------DLEKSK------------ -------------------------------------------------- -------------------------------------------------- -IKTELN-----------S------------------------------- ---------SADNEQPLDKTGHVKDTNPEDGIIISEHGEDEMDMES---- EKEEE--------------------------------------------- ---------KPKT-GGTFS------------------------------- ---------------------------NALSSLNVLRP-----------G EIPDAAFIHAARKKRQMARELGDFTP-HDNE-PGKGRLVR-ED--ENDA- SD-DEDDDEKRRIVFSVKEKSQRQKIAEE--I---GIEGSDDDALV-TGE QDEELSRWEQEQIRKGINIPQVQASQPTEV-NMYYQNTYQAMPYGSSYGI PYSY--TAY-----------------------------GSS-DAKSQKTD NSAPFKTPSNEMTPVTIDLVKKQLKD-R---------------------- ------------------------------------------LDSMKELH KTNRQQHEKHLQSRVDSTRAIERLEGSSGGIGERYKFLQEMRGYVQDLLE CFSEKVPLINELESAIHQLYKQRASRLVQRRQDDIKDESSEFSSHS---- ---------------NKALMAPNLDSFGRDRALYQEHAK-RRIAERE--- ---ARR-TRR-RQAREQTGKMADHLEGLSSDDEETSTDITNFNLEK--DR ISKESSKVFEDVLESFYSIDCIKSQFEAWRSKYYMSYKDAYIGLCLPKLF NPLIRLQLLTWTPLE----------------------------------- -AKCRDFENMLWFESLLFYGCEERE--QEKDDVDVALLPTIVEKVILPKL TVIAENMWDPFSTT--------------QTSRMVGITLKLINGYPSVVNA ENKN-----TQVYLKALLLRMRRTLDDDVFMPLYPKNVLENKNSGPYLFF QRQFWSSVKLLGNFLQWYGIFSNKTLQELSIDGLLNRYILMAFQNSEYGD DSIKKAQNVINCFPKQWFMNLKGERTISQLENFCRYLVHLADTIYRNSIG CSDVDKRNARENIKQIVKLLASIRALDHAMSVASDH-------------- --N------------VKEFKSLIEGK-- >ENSMICP00000031482 -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ---MF--------------------------------------------- ----------------------------------------RKARRVNVRK RNDSEEEE-------RER-------------------------------- -----------------------------------EEExx---------- ------------------------------xx------------------ -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- --------------x----------------------------------- -------------------------------------------------- -xx----------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ---------x---------------------------------------- -------------------------------------------------- ----------------------------------------x--------- ----------xx-------------------------------------- -------------------------------------------------- ----------------xxxx-----xx----------------------- ---------------------------------------------xxx-- ------xxx----------------------------------------- -------------------------------------------------- -------------------------------------------------- -----x-------------------------------------------- ---------------xxExx------------------------------ ----------------------------------------------xxxx x-------------xPx--------------------------------- ---------------------------------xx-------------xx xxx----------------------------------------------- -------------------------------------------------- -------------------------------------------------- -----------------------------------------------xxx xxxxxxxGxxxxxxxxxRKRPRENKE--VP-------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ----------RAS-----------------------------------LL SF-QDE-EE-EN-------------------------------------- -----------------------------------------------E-- ------EVFKVKKSSYSKKIVKLLKKEYKE-------------------- --------------------------------DLEKSK------------ -------------------------------------------------- -------------------------------------------------- -IKTELN-----------S------------------------------- ---------SADNEQPLDKTGHVKDTSQEDGVIISEHGEDEMDMES---- EKEEE--------------------------------------------- ---------KPKA-GGAFS------------------------------- ---------------------------NALSSLNVLRP-----------G EIPDAAFIHAARKKRQMARELGDFTP-HDNE-PGKGRLVR-ED--ENDA- SD-DEDDDEKRRIVFSVKEKSQRQKIAEE--I---GIEGSDDDALV-TGE QDEELSRWEQEQIRKGINIPQVQASQPAEV-NMYYQNTYQTMPYGSSYGI PYSY--TAY-----------------------------GSS-DAKSQKTD NTVPFKTPSNEMTPVTIDLVKKQLKD-R---------------------- ------------------------------------------LDSMKELH KTNRQQHEKHLQSRVDSTRAIERLEGSSGGIGERYKFLQEMRGYVQDLLE CFSEKVPLINELESAIHQLYKQRASRLVQRRQDDIKDESSEFSSHS---- ---------------NKALMAPNLDSFGRDRALYQEHAK-RRIAERE--- ---ARR-TRR-RQAREQTGKMADHLEGLSSDDEETSTDITNFNLEK--DR ISKESSKVFEDVLESFCSIDCIKAQFEAWRSKYYMSYKDAYIGLCLPKLF NPLIRLQLLTWTPLE----------------------------------- -AKCRDFENMLWFESLLFYGCEERE--QEKDDVDVALLPTIVEKVILPKL TVIAENMWDPFSTT--------------QTSRMVGITLKLINGYSSVVNA ENKN-----TQVYLKALLLRMRRTLDDDVFMPLYPKNVLENKNSGPYLFF QRQFWSSVKLLGNFLQWYGIFSNKTLQELSIDGLLNRYILMAFQNSEYGD DSIKKAQNVINCFPKQWFMNLKGERTISQLENFCRYLVHLADTIYRNSIG CSDVEKRNARENIKQIVKLLASVRALDHAMSVASDH-------------- --N------------VKEFKSLIEGK-- >ENSPCOP00000031608 -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ---MF--------------------------------------------- ----------------------------------------RKARRVNVRK RNDSEEEE-------RER-------------------------------- -----------------------------------DEExx---------- ------------------------------xx------------------ -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- --------------x----------------------------------- -------------------------------------------------- -xx----------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ---------x---------------------------------------- -------------------------------------------------- ----------------------------------------x--------- ----------xx-------------------------------------- -------------------------------------------------- ----------------xxxx-----xx----------------------- ---------------------------------------------xxx-- ------xxx----------------------------------------- -------------------------------------------------- -------------------------------------------------- -----x-------------------------------------------- ---------------xxExx------------------------------ ----------------------------------------------xxxx x-------------xPx--------------------------------- ---------------------------------xx-------------xx xxx----------------------------------------------- -------------------------------------------------- -------------------------------------------------- -----------------------------------------------xxx xxxxxxxGxxxxxxxxxRKRPRENKE--VP-------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ----------RAS-----------------------------------LL SF-QDE-EE-EN-------------------------------------- -----------------------------------------------E-- ------EVFKVKKSSYSKKIVKLLKKEYKE-------------------- --------------------------------DLEKSK------------ -------------------------------------------------- -------------------------------------------------- -IKTELN-----------S------------------------------- ---------SADNEQPLDKTGHVKDISQEDGVIIGEHGEDEMDMES---- EKEDE--------------------------------------------- ---------KPKA-GGAFS------------------------------- ---------------------------NALSSLNVLRP-----------G EIPDAAFIHAARKKRQMARELGDFTP-HDNE-PGKGRLVR-ED--ENDA- SD-DEDDDEKRRIVFSVKEKSQRQKIAEE--I---GIEGSDDDALV-TGE QDEELSRWEQEQIRKGINIPQVQASQPAEV-NMYYQNTYQTMPYGSSYGI PYSY--TAY-----------------------------GSS-DAKSQKTD NTVPFKTPSNEMTPVTIDLVKKQLKD-R---------------------- ------------------------------------------LDSMKELH KTNRQQHEKHLQSRADSTRAIERLEGSSGGIGERYKFLQEMRGYVQDLLE CFSEKVPLINELESAIHQLYKQRASRLVQRRQDDIKDESSEFSSHS---- ---------------NKALMAPNLDSFGRDRALYQEHAK-RRIAERE--- ---ARR-TRR-RQAREQTGKMADHLEGLSSDDEETSTDITNFNLEK--DR ISKESSKVFEDVLESFCSIDCIKAQFEAWRSKYYMSYKDAYIGLCLPKLF NPLIRLQLLTWTPLE----------------------------------- -AKCRDFENMLWFESLLFYGCEERE--QEKDDVDIALLPTIVEKVILPKL TVIAENMWDPFSTT--------------QTSRMVGITLKLINGYSSVVNA ENKN-----TQVYLKALLLRMRRTLDDDVFMPLYPKNVLENKNSGPYLFF QRQFWSSVKLLGNFLQWYGIFSNKTLQELSIDGLLNRYILMAFQNSEYGD DSIKKAQNVINCFPKQWFMNLKGERTIFQLENFCRYLVHLADTIYRNSIG CSDVEKRNARENIKQIVKLLASVRALDHAMSVASDH-------------- --N------------VKEFKSLIEGK-- >ENSPSMP00000011864 -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ---MF--------------------------------------------- ----------------------------------------RKARRVNVRK RNDSEEEE-------RER-------------------------------- -----------------------------------EEExx---------- ------------------------------xx------------------ -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- --------------x----------------------------------- -------------------------------------------------- -xx----------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ---------x---------------------------------------- -------------------------------------------------- ----------------------------------------x--------- ----------xx-------------------------------------- -------------------------------------------------- ----------------xxxx-----xx----------------------- ---------------------------------------------xxx-- ------xxx----------------------------------------- -------------------------------------------------- -------------------------------------------------- -----x-------------------------------------------- ---------------xxExx------------------------------ ----------------------------------------------xxxx x------------xxPx--------------------------------- ---------------------------------xx-------------xx xxx----------------------------------------------- -------------------------------------------------- -------------------------------------------------- -----------------------------------------------xxx xxxxxxxGxxxxxxxxxRKRPRENKE--VP-------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ----------RAS-----------------------------------LL SF-QDE-EE-EN-------------------------------------- -----------------------------------------------E-- ------EVFKVKKSSYSKKIVKLLKKEYKE-------------------- --------------------------------DLEKSK------------ -------------------------------------------------- -------------------------------------------------- -IKTELN-----------S------------------------------- ---------SADNEQPLDKTGHVKDTSQEDGVIISEHGEDEMDMES---- EKEEE--------------------------------------------- ---------KPKA-GGTFS------------------------------- ---------------------------NALSSLNVLRP-----------G EIPDAAFIHAARKKRQMARELGDFTP-HDNE-PGKGRLVR-ED--ENDA- SD-DEDDDEKRRIVFSVKEKSQRQKIAEE--I---GIEGSDDDALV-TGE QDEELSRWEQEQIRKGINIPQVQASQPAEV-NMYYQNTYQTMPYGSSYGI PYSY--TAY-----------------------------GSS-DAKSQKTD NTVPFKTPSNEMTPVTIDLVKKQLKD-R---------------------- ------------------------------------------LDSMKELH KTNRQQHEKHLQSRVDSTRAIERLEGSSGGIGERYKFLQEMRGYVQDLLE CFSEKVPLINELESAIHQLYKQRASRLVQRRQDDIKDESSEFSSHS---- ---------------NKALMAPNLDSFGRDRALYQEHAK-RRIAERE--- ---ARR-TRR-RQAREQTGKMADHLEGLSSDDEETSTDITNFNLEK--DR ISKESSKVFEDVLESFCSIDCIKAQFEAWRSKYYMSYKDAYIGLCLPKLF NPLIRLQLLTWTPLE----------------------------------- -AKCRDFENMLWFESLLFYGCEERE--QEKDDVDVALLPTIVEKVILPKL TVIAENMWDPFSTT--------------QTSRMVGITLKLINGYPSVVNA ENKN-----TQVYLKALLLRMRRTLDDDVFMPLYPKNVLENKNSGPYLFF QRQFWSSVKLLGNFLQWYGIFSNKTLQELSIDGLLNRYILMAFQNSEYGD DSIKKAQNVINCFPKQWFMNLKGERTISQLENFCRYLVHLADTIYRNSIG CSDVEKRNARENIKQIVKLLASVRALDHAMSVASDH-------------- --N------------VKEFKSLIEGK-- >ENSCCNP00000030398 -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ---MF--------------------------------------------- ----------------------------------------RKARRVNVRK RNDSEEEE-------RER-------------------------------- -----------------------------------DEExx---------- ------------------------------xx------------------ -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- --------------x----------------------------------- -------------------------------------------------- -xx----------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- --------xx---------------------------------------- -------------------------------------------------- ----------------------------------------x--------- ----------xx-------------------------------------- -------------------------------------------------- ----------------xxxx-----xx----------------------- ---------------------------------------------xxx-- ------xxx----------------------------------------- -------------------------------------------------- -------------------------------------------------- -----x-------------------------------------------- ---------------xxExx------------------------------ ----------------------------------------------xxxx x-------------xPx--------------------------------- ---------------------------------xx-------------xx xxx----------------------------------------------- -------------------------------------------------- -------------------------------------------------- -----------------------------------------------xxx xxxxxxxGxxxxxxxxxRKRPRENKE--VP-------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ----------RAS-----------------------------------LL SF-QDE-EE-EN-------------------------------------- -----------------------------------------------E-- ------EVFKVKKSSYSKKIVKLLKKEYKE-------------------- --------------------------------DLEKSK------------ -------------------------------------------------- -------------------------------------------------- -IKTELN-----------S------------------------------- ---------SADNDQPVDKSGHVKDTNQEDGVIISEHGEDEMDMES---- EKEEE--------------------------------------------- ---------KPKT-AGAFS------------------------------- ---------------------------NALSSLNVLRP-----------G EIPDAAFIHAARKKRQMARELGDFTP-HDNE-PGKGRLVR-ED--ENDA- SD-DEDDDEKRRIVFSVKEKSQRQKIAEE--I---GIEGSDDDALV-TGE QDEELSRWEQEQIRKGINIPQVQASQPSEV-NMYYQSTYQTMPYGSSYDI PYSY--TTY-----------------------------GSS-DAKSQKTD NTVPFKTPSNEMTPVTIDLVKKQLKD-R---------------------- ------------------------------------------LDSMKELH KTNRQQHEKHLQSRVDSTRAIERLEGSSGGIGERYKFLQEMRGYVQDLLE CFSEKVPLINELESAIHQLYKQRASRLVQRRQDDIKDESSEFSSHS---- ---------------NKALMAPNLDSFGRDRALYQEHAK-RRIAERE--- ---ARR-TRR-RQAREQTGKMADHLEGLSSDDEETSTDITNFNLEK--DR ISKESSKVFEDVLESFYSIDCIKSQFEAWRSKYYMSYKDAYIGLCLPKLF NPLIRLQLLTWTPLE----------------------------------- -AKCRDFENMLWFESLLFYGCEERE--QEKDDVDVALLPTIVEKVILPKL TVIAENMWDPFSTT--------------QTSRMVGITLKLINGYPSVVNA ENKN-----TQVYLKALLLRMRRTLDDDVFMPLYPKNVLENKNSGPYLFF QRQFWSSVKLLGNFLQWYGIFSNKTLQELSIDGLLNRYILMAFQNSEYGD DSIKKAQNVINCFPKQWFMNLKGERTISQLENFCRYLVHLADTIYRNSIG CSDVEKRNARENIKQIVKLLASVRALDHAMSVASDH-------------- --N------------VKEFKSLIEGK-- >ENSMPUP00000001214 -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ---MF--------------------------------------------- ----------------------------------------RKARRVNVRK RNDSEEEE-------RER-------------------------------- -----------------------------------DEExx---------- ------------------------------xx------------------ -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- --------------x----------------------------------- -------------------------------------------------- -xx----------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- --------xx---------------------------------------- -------------------------------------------------- ----------------------------------------x--------- ----------xx-------------------------------------- -------------------------------------------------- ----------------xxxxxxxxxxxx---------------------- ---------------------------------------------xxx-- ------xxx----------------------------------------- -------------------------------------------------- -------------------------------------------------- -----x-------------------------------------------- ---------------xxExx------------------------------ ----------------------------------------------xxxx x-------------xPx--------------------------------- ---------------------------------xx-------------xx xxx----------------------------------------------- -------------------------------------------------- -------------------------------------------------- -----------------------------------------------xxx xxxxxxxGxxxxxxxxxRKRPRENKE--VP-------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ----------RAS-----------------------------------LL SF-QDE-EE-EN-------------------------------------- -----------------------------------------------E-- ------EVFKVKKSSYSKKIVKLLKKEYKE-------------------- --------------------------------DLEKSK------------ -------------------------------------------------- -------------------------------------------------- -IKTELN-----------S------------------------------- ---------STDSEPPLDKTGHVKDTSQEDGLIISEHGEDEMDMES---- EKEEE--------------------------------------------- ---------KPKA-GGAFS------------------------------- ---------------------------NALSSLNVLRP-----------G EIPDAAFIHAARKKRQMARELGDFTP-HDNE-PGKGRLVR-ED--ENDA- SD-DEDDDEKRRIVFSVKEKSQRQKIAEE--I---GIEGSDDDALV-TGE QDEELSRWEQEQIRKGINIPQVQSSQPTEV-NMYYQNTYQTMPYGSSYGI PYSY--TAY-----------------------------GSS-DAKSQKTD NTVPFKTPSNEMTPVTIDLVKKQLKD-R---------------------- ------------------------------------------LDSMKELH KTNRQQHEKHLQSRVDSTRAIERLEGSSGGIGERYKFLQEMRGYVQDLLE CFSEKVPLINELESAIHQLYKQRASRLVQRRQDDIKDESSEFSSHS---- ---------------NKALMAPNLDSFGRDRALYQEHAK-RRIAERE--- ---ARR-TRR-RQAREQTGKMADHLEGLSSDDEETSTDITNFNLEK--DR ISKESSKVFEDVLESFYSIDCIKSQFEAWRSKYYLSYKDAYIGLCLPKLF NPLIRLQLLTWTPLE----------------------------------- -AKCRDFENMLWFESLLFYGCEERE--QEKDDVDVALLPTIVEKVILPKL TVIAENMWDPFSTT--------------QTSRMVGITLKLINGYPSVVNA ENKN-----TQVYLKALLLRMRRTLDDDVFMPLYPKNVLENKNSGPYLFF QRQFWSSVKLLGNFLQWYGIFSNKTLQELSIDGLLNRYILMAFQNSEYGD DSIKKAQNVINCFPKQWFMNLKGERTISQLENFCRYLVHLADTIYRNSIG CSDVEKRNARENIKQIVKLLASVRALDHAMSVASDH-------------- --N------------VKEFKSLIEGK-- >ENSPTIP00000018959 -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ------------------------------------------------xx xxxxxxxGxxxxxxxxxRKRQRENKE--VP-------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ----------RAS-----------------------------------LL SF-QDE-EE-EN-------------------------------------- -----------------------------------------------E-- ------EVFKVKKSSYSKKIVKLLKKEYKE-------------------- --------------------------------DLEKSK------------ -------------------------------------------------- -------------------------------------------------- -IKTELN-----------S------------------------------- ---------SADSEPPLDKTGHIKDTSQEDGVIISEHGEDEMDMES---- EKEEE--------------------------------------------- ---------KPKA-GGAFS------------------------------- ---------------------------NALSSLNVLRP-----------G EIPDAAFIHAARKKRQMARELGDFTP-HDSE-PGKGRLVR-ED--ENDA- SD-DEDDDEKRRIVFSVKEKSQRQKIAEE--I---GIEGSDDDALV-TGE QDEELSRWEQEQIRKGINIPQVQASQPTEV-NMYYQNTYQTIPYGSSYGI PYSY--TAY-----------------------------GSS-DAKSQKTD NTVPFKTPSNEMTPVTIDLVKKQLKD-R---------------------- ------------------------------------------LDSVKELH KTNRQQHEKHLQSRVDATRAIERLEGSSGGVGERYKFLQEMRGYVQDLLE CFSEKVPLINELESAIHQLYKQRASRLVQRRQDDIKDESSEFSSHS---- ---------------NKALMAPNLDSFGRDRALYQEHAK-RRIAERE--- ---ARR-TRR-RQAREQTGKMADHLEGLSSDDEETSTDITNFNLEK--DR ISKESSKVFEDVLESFYSIDCIKSQFEAWRSKYYLSYKDAYIGLCLPKLF NPLIRLQLLTWTPLE----------------------------------- -AKCRDFENMLWFESLLFYGCEERE--QEKDDVDVALLPTIVEKVILPKL TVIAENMWDPFSTT--------------QTSRMVGITLKLINGYPSVVNA ENKN-----TQVYLKALLLRMRRTLDDDVFMPLYPKNVLENKNSGPYLFF QRQFWSSVKLLGNFLQWYGIFSNKTLQELSIDGLLNRYILMAFQNSEYGD DSIKKAQNVINCFPKQWFMNLKGERTISQLENFCRYLVHLADTIYRNSIG CSDVEKRNARENIKQIVKLLASVRALDHAMSVASDH-------------- --N------------VKEFKSLIEGK-- >ENSFCAP00000011596 x-------------------x---------------------xxxxxxxx xxxx--------------------------------xxxxxxxxxx---- --------xxxxxxxxxxxxxxxxxxxxxxx------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- --GMF--------------------------------------------- ----------------------------------------RKARRVNVRK RNDSEEEE-------RER-------------------------------- -----------------------------------DEExx---------- ------------------------------xx------------------ -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- --------------x----------------------------------- -------------------------------------------------- -xx----------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- --------xx---------------------------------------- -------------------------------------------------- ----------------------------------------x--------- ----------xx-------------------------------------- -------------------------------------------------- ----------------xxxx-----xxx---------------------- ---------------------------------------------xxx-- ------xxx----------------------------------------- -------------------------------------------------- -------------------------------------------------- -----x-------------------------------------------- ---------------xxExx------------------------------ ----------------------------------------------xxxx x-------------xPx--------------------------------- ---------------------------------xx-------------xx xxx----------------------------------------------- -------------------------------------------------- -------------------------------------------------- -----------------------------------------------xxx xxxxxxxGxxxxxxxxxRKRPRENKE--VP-------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ----------RAS-----------------------------------LL SF-QDE-EE-EN-------------------------------------- -----------------------------------------------E-- ------EVFKVKKSSYSKKIVKLLKKEYKE-------------------- --------------------------------DLEKSK------------ -------------------------------------------------- -------------------------------------------------- -IKTELN-----------S------------------------------- ---------SADSEPPLDKTGHIKDTSQEDGVIISEHGEDEMDMES---- EKEEE--------------------------------------------- ---------KPKA-GGAFS------------------------------- ---------------------------NALSSLNVLRP-----------G EIPDAAFIHAARKKRQMARELGDFTP-HDSE-PGKGRLVR-ED--ENDA- SD-DEDDDEKRRIVFSVKEKSQRQKIAEE--I---GIEGSDDDALV-TGE QDEELSRWEQEQIRKGINIPQVQASQPTEV-NMYYQNTYQTIPYGSSYGI PYSY--TAY-----------------------------GSS-DAKSQKTD NTVPFKTPSNEMTPVTIDLVKKQLKD-R---------------------- ------------------------------------------LDSVKELH KTNRQQHEKHLQSRVDATRAIERLEGSSGGVGERYKFLQEMRGYVQDLLE CFSEKVPLINELESAIHQLYKQRASRLVQRRQDDIKDESSEFSSHS---- ---------------NKALMAPNLDSFGRDRALYQEHAK-RRIAERE--- ---ARR-TRR-RQAREQTGKMADHLEGLSSDDEETSTDITNFNLEK--DR ISKESSKVFEDVLESFYSIDCIKSQFEAWRSKYYLSYKDAYIGLCLPKLF NPLIRLQLLTWTPLE----------------------------------- -AKCRDFENMLWFESLLFYGCEERE--QEKDDVDVALLPTIVEKVILPKL TVIAENMWDPFSTT--------------QTSRMVGITLKLINGYPSVVNA ENKN-----TQVYLKALLLRMRRTLDDDVFMPLYPKNVLENKNSGPYLFF QRQFWSSVKLLGNFLQWYGIFSNKTLQELSIDGLLNRYILMAFQNSEYGD DSIKKAQNVINCFPKQWFMNLKGERTISQLENFCRYLVHLADTIYRNSIG CSDVEKRNARENIKQIVKLLASVRALDHAMSVASDH-------------- --N------------VKEFKSLIEGK-- >ENSPPRP00000001131 -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ---MF--------------------------------------------- ----------------------------------------RKARRVNVRK RNDSEEEE-------RER-------------------------------- -----------------------------------DEExx---------- ------------------------------xx------------------ -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- --------------x----------------------------------- -------------------------------------------------- -xx----------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- --------xx---------------------------------------- -------------------------------------------------- ----------------------------------------x--------- ----------xx-------------------------------------- -------------------------------------------------- ----------------xxxx-----xxx---------------------- ---------------------------------------------xxx-- ------xxx----------------------------------------- -------------------------------------------------- -------------------------------------------------- -----x-------------------------------------------- ---------------xxExx------------------------------ ----------------------------------------------xxxx x-------------xPx--------------------------------- ---------------------------------xx-------------xx xxx----------------------------------------------- -------------------------------------------------- -------------------------------------------------- -----------------------------------------------xxx xxxxxxxGxxxxxxxxxRKRPRENKE--VP-------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ----------RAS-----------------------------------LL SF-QDE-EE-EN-------------------------------------- -----------------------------------------------E-- ------EVFKVKKSSYSKKIVKLLKKEYKE-------------------- --------------------------------DLEKSK------------ -------------------------------------------------- -------------------------------------------------- -IKTELN-----------S------------------------------- ---------SADSEPPLDKTGHIKDTSQEDGVIISEHGEDEMDMES---- EKEEE--------------------------------------------- ---------KPKA-GGAFS------------------------------- ---------------------------NALSSLNVLRP-----------G EIPDAAFIHAARKKRQMARELGDFTP-HDSE-PGKGRLVR-ED--ENDA- SD-DEDDDEKRRIVFSVKEKSQRQKIAEE--I---GIEGSDDDALV-TGE QDEELSRWEQEQIRKGINIPQVQASQPTEV-NMYYQNTYQTIPYGSSYGI PYSY--TAY-----------------------------GSS-DAKSQKTD NTVPFKTPSNEMTPVTIDLVKKQLKD-R---------------------- ------------------------------------------LDSVKELH KTNRQQHEKHLQSRVDATRAIERLEGSSGGVGERYKFLQEMRGYVQDLLE CFSEKVPLINELESAIHQLYKQRASRLVQRRQDDIKDESSEFSSHS---- ---------------NKALMAPNLDSFGRDRALYQEHAK-RRIAERE--- ---ARR-TRR-RQAREQTGKMADHLEGLSSDDEETSTDITNFNLEK--DR ISKESSKVFEDVLESFYSIDCIKSQFEAWRSKYYLSYKDAYIGLCLPKLF NPLIRLQLLTWTPLE----------------------------------- -AKCRDFENMLWFESLLFYGCEERE--QEKDDVDVALLPTIVEKVILPKL TVIAENMWDPFSTT--------------QTSRMVGITLKLINGYPSVVNA ENKN-----TQVYLKALLLRMRRTLDDDVFMPLYPKNVLENKNSGPYLFF QRQFWSSVKLLGNFLQWYGIFSNKTLQELSIDGLLNRYILMAFQNSEYGD DSIKKAQNVINCFPKQWFMNLKGERTISQLENFCRYLVHLADTIYRNSIG CSDVEKRNARENIKQIVKLLASVRALDHAMSVASDH-------------- --N------------VKEFKSLIEGK-- >ENSAMEP00000015826 -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ---MF--------------------------------------------- ----------------------------------------RKARRVNVRK RNDSEEEE-------RER-------------------------------- -----------------------------------DEExx---------- ------------------------------xx------------------ -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- --------------x----------------------------------- -------------------------------------------------- -xx----------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- --------xx---------------------------------------- -------------------------------------------------- ----------------------------------------x--------- ----------xx-------------------------------------- -------------------------------------------------- ----------------xxxx-----xxx---------------------- ---------------------------------------------xxx-- ------xxx----------------------------------------- -------------------------------------------------- -------------------------------------------------- -----x-------------------------------------------- ---------------xxxxx------------------------------ ----------------------------------------------xxxx x-------------xxx--------------------------------- ---------------------------------xx-------------xx xxx----------------------------------------------- -------------------------------------------------- -------------------------------------------------- -----------------------------------------------xxx xxxxxxxGxxxxxxxxxRKRPRENKE--VP-------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ----------RAS-----------------------------------LL SF-QDE-EE-EN-------------------------------------- -----------------------------------------------E-- ------EVFKVKKSSYSKKIVKLLKKEYKE-------------------- --------------------------------DLEKSK------------ -------------------------------------------------- -------------------------------------------------- -IKTELN-----------S------------------------------- ---------SADNEPLLDKAGHVKDTSQEDGVIISEHGEDEMDMES---- EKEEE--------------------------------------------- ---------KPKA-GGAFS------------------------------- ---------------------------NALSSLNVLRP-----------G EIPDAAFIHAARKKRQMARELGDFTP-HDSE-PGKGRLVR-ED--ENDA- SD-DEDDDEKRRIVFSVKEKSQRQKIAEE--I---GIEGSDDDALV-TGE QDEELSRWEQEQIRKGINIPQVQASQPTEV-NMYYQNTYQTMPYGSSYGI PYSY--TAY-----------------------------GSS-DAKSQKTD NTVPFKTPSNEMTPVTIDLVKKQLKD-R---------------------- ------------------------------------------LDSMKELH KTNRQQHEKHLQSRVDSTRAIERLEGSSGGIGERYKFLQEMRGYVQDLLE CFSEKVPLINELESAIHQLYKQRASRLVQRRQDDIKDESSEFSSHS---- ---------------NKALMAPNLDSFGRDRALYQEHAK-RRIAERE--- ---ARR-TRR-RQAREQTGKMADHLEGLSSDDEETSTDITNFNLEK--DR ISKESSKVFEDVLESFYSIDCIKSQFEAWRSKYYLSYKDAYIGLCLPKLF NPLIRLQLLTWTPLE----------------------------------- -AKCRDFENMLWFESLLFYGCEERE--QEKDDVDVALLPTIVEKVILPKL TVIAENMWDPFSTT--------------QTSRMVGITLKLINGYPSVVNA ENKN-----TQVYLKALLLRMRRTLDDDVFMPLYPKNVLENKNSGPYLFF QRQFWSSVKLLGNFLQWYGIFSNKTLQELSIDGLLNRYILMAFQNSEYGD DSIKKAQNVISCFPKQWFMNLKGERTISQLENFCRYLVHLADTIYRNSIG CSDVEKRNARENIKQIVKLLASVHALDHAMSVASDH-------------- --N------------VKEFKSLIEGK-- >ENSUAMP00000026663 -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ---MF--------------------------------------------- ----------------------------------------RKARRVNVRK RNDSEEEE-------RER-------------------------------- -----------------------------------DEExx---------- ------------------------------xx------------------ -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- --------------x----------------------------------- -------------------------------------------------- -xx----------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- --------xx---------------------------------------- -------------------------------------------------- ----------------------------------------x--------- ----------xx-------------------------------------- -------------------------------------------------- ----------------xxxx-----xxx---------------------- ---------------------------------------------xxx-- ------xxx----------------------------------------- -------------------------------------------------- -------------------------------------------------- -----x-------------------------------------------- ---------------xxExx------------------------------ ----------------------------------------------xxxx x-------------xPx--------------------------------- ---------------------------------xx-------------xx xxx----------------------------------------------- -------------------------------------------------- -------------------------------------------------- -----------------------------------------------xxx xxxxxxxGxxxxxxxxxRKRPRENKE--VP-------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ----------RAS-----------------------------------LL SF-QDE-EE-EN-------------------------------------- -----------------------------------------------E-- ------EVFKVKKSSYSKKIVKLLKKEYKE-------------------- --------------------------------DLEKSK------------ -------------------------------------------------- -------------------------------------------------- -IKTELN-----------S------------------------------- ---------SADNEPPLDKAGHVKDTSQEDGVIISEHGEDEMDMES---- EKEEE--------------------------------------------- ---------KPKA-GGAFS------------------------------- ---------------------------NALSSLNVLRP-----------G EIPDAAFIHAARKKRQMARELGDFTP-HDSE-PGKGRLVR-ED--ENDA- SD-DEDDDEKRRIVFSVKEKSQRQKIAEE--I---GIEGSDDDALV-TGE QDEELSRWEQEQIRKGINIPQVQASQPTEV-NMYYQNTYQTMPYGSSYGI PYSY--TAY-----------------------------GSS-DAKSQKTD NTVPFKTPSNEMTPVTIDLVKKQLKD-R---------------------- ------------------------------------------LDSMKELH KTNRQQHEKHLQSRVDSTRAIERLEGSSGGIGERYKFLQEMRGYVQDLLE CFSEKVPLINELESAIHQLYKQRASRLVQRRQDDIKDESSEFSSHS---- ---------------NKALMAPNLDSFGRDRALYQEHAK-RRIAERExxx -xx----------AREQTGKMADHLEGLSSDDEETSTDITNFNLEK--DR ISKESSKVFEDVLESFYSIDCIKSQFEAWRSKYYLSYKDAYIGLCLPKLF NPLIRLQLLTWTPLE----------------------------------- -AKCRDFENMLWFESLLFYGCEERE--QEKDDVDVALLPTIVEKVILPKL TVIAENMWDPFSTT--------------QTSRMVGITLKLINGYPSVVNA ENKN-----TQVYLKALLLRMRRTLDDDVFMPLYPKNVLENKNSGPYLFF QRQFWSSVKLLGNFLQWYGIFSNKTLQELSIDGLLNRYILMAFQNSEYGD DSIKKAQNVISCFPKQWFMNLKGERTISQLENFCRYLVHLADTIYRNSIG CSDVEKRNARENIKQIVKLLASVRALDHAMSVASDH-------------- --N------------VKEFKSLIEGK-- >ENSECAP00000014331 -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ---MF--------------------------------------------- ----------------------------------------RKARRVNVRK RNDSEEEE-------RER-------------------------------- -----------------------------------DEExx---------- ------------------------------xx------------------ -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- --------------x----------------------------------- -------------------------------------------------- -xx----------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- --------xx---------------------------------------- -------------------------------------------------- ----------------------------------------x--------- ----------xx-------------------------------------- -------------------------------------------------- ----------------xxxx-----xxx---------------------- ---------------------------------------------xxx-- ------xxx----------------------------------------- -------------------------------------------------- -------------------------------------------------- -----x-------------------------------------------- ---------------xxExx------------------------------ ----------------------------------------------xxxx x-------------xPx--------------------------------- ---------------------------------xx-------------xx xxx----------------------------------------------- -------------------------------------------------- -------------------------------------------------- -----------------------------------------------xxx xxxxxxxGxxxxxxxxxRKRPRENKE--VP-------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ----------RAS-----------------------------------LL SF-QDE-EE-EN-------------------------------------- -----------------------------------------------E-- ------EVFKVKKSSYSKKIVKLLKKEYKE-------------------- --------------------------------DLEKSK------------ -------------------------------------------------- -------------------------------------------------- -IKTELN-----------S------------------------------- ---------SADNEPSLDKTGHVKDTSQEDGVIISEHGEDEMDMES---- EKEEE--------------------------------------------- ---------KPKA-GGAFS------------------------------- ---------------------------NALSSLNVLRP-----------G EIPDAAFIHAARKKRQMARELGDFTP-HDSE-PGKGRLVR-ED--ENDA- SD-DEDDDEKRRIVFSVKEKSQRQKIAEE--I---GIEGSDDDALV-TGE QDEELSRWEQEQIRKGINIPQVQASQPAEV-NMYYQNTYQTMPYGSSYGI PYSY--TAY-----------------------------GSS-DAKSQKTD NTVPFKTPSNEMTPVTIDLVKKQLKD-R---------------------- ------------------------------------------LDSMKELH KTNRQQHEKHLQSRVDSTRAIERLEGSSGGIGERYKFLQEMRGYVQDLLE CFSEKVPLINELESAIHQLYKQRASRLVQRRQDDIKDESSEFSSHS---- ---------------NKALMAPNLDSFGRDRALYQEHAK-RRIAERE--- ---ARR-TRR-RQAREQTGKMADHLEGLSSDDEETSTDITNFNLEK--DR ISKESSKVFEDVLESFYSIDCIKSQFEAWRSKYYMSYKDAYIGLCLPKLF NPLIRLQLLTWTPLE----------------------------------- -AKCRDFETMLWFESLLFYGCEERE--QEKDDVDVALLPTIVEKVILPKL TVIAENMWDPFSTT--------------QTSRMVGITLKLINGYPSVVNA ENKN-----TQVYLKALLLRMRRTLDDDVFMPLYPKNVLENKNSGPYLFF QRQFWSSVKLLGNFLQWYGIFSNKTLQELSIDGLLNRYILMAFQNSEYGD DSIKKAQNVINCFPKQWFMNLKGERTISQLENFCRYLVHLADTIYRNSIG CSDVEKRNARENIKQIVKLLASVRALDHAMSVASDH-------------- --N------------VKEFKSLIEGK-- >ENSTSYP00000006051 -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ---MF--------------------------------------------- ----------------------------------------RKARRVNVRK RNDSEEEE-------RER-------------------------------- -----------------------------------DEExx---------- ------------------------------xx------------------ -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- --------------x----------------------------------- -------------------------------------------------- -xx----------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ------xxxxxxxxx----------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -----------------------------------------------xxx x-------------xPx--------------------------------- ---------------------------------xx-------------xx xxx----------------------------------------------- -------------------------------------------------- -------------------------------------------------- -----------------------------------------------xxx xxxxxxxSxxxxxxxxxRKRPRENKE--VP-------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ----------RAS-----------------------------------LL SF-QDE-EE-ET-------------------------------------- -----------------------------------------------E-- ------EVFKVKKSSYSKKIVKLLKKEYKE-------------------- --------------------------------DLEKSK------------ -------------------------------------------------- -------------------------------------------------- -IKIELN-----------S------------------------------- ---------SADNEHPLDKTGHIKDTNQEDGVIISEHGEDEMDMES---- EKEEE--------------------------------------------- ---------KPKA-GGAFS------------------------------- ---------------------------NALSSLNVLRP-----------G EIPDAAFIHAARKKRQMARELGDFTP-HDNE-PGKGRLVR-ED--ENDA- SD-DEDDDEKRRIVFSVKEKSQRQKIAEE--I---GIEGSDDDALV-TGE QDEELSRWEQEQIRKGINIPQVQASQPTEV-NMYYQNTYQTMPYGSSYGI PYSY--TTY-----------------------------GSS-DAKSQKTD NTVPFKTPSNEMTPVTIDLVKKQLKD-R---------------------- ------------------------------------------LDSMKELH KTNRQQHEKHLQSRVDSTRAIERLEGSSGGIGERYKFLQEMRGYVQDLLE CFSEKVPLINELESAIHQLYKQRASRLVQRRQDDIKDESSEFSSHS---- ---------------NKALMAPNLDSFGRDRALYQEHAK-RRIAERE--- ---ARR-TRR-RQAREQTGKMADHLEGLSSDDEETSTDITNFNLEK--DR ISKESSKVFEDVLESFYSIDCIKSQFEAWRSKYYMSYKDAYIGLCLPKLF NPLIRLQLLTWTPLE----------------------------------- -AKCRDFESMLWFESLLFYGCEERE--QEKDDVDVALLPTIVEKVILPKL TVIAENVWDPFSTT--------------QTSRMVGITLKLINGYPSVVNA ENKN-----TQVYLKALLLRMRRTLDDDVFMPLYPKNVLENKNSGPYLFF QRQFWSSVKLLGNFLQWYGIFSNKTLQELSIDGLLNRYILMAFQNSEYGD DSIKKAQNVINCFPKQWFINLKGERTISQLENFCRYLVHLADTIYRNSIG CSDVEKRNARENIKQIVKLLASVRALDHAMSVASDH-------------- --N------------VKEFKSLIEGK-- >ENSFDAP00000002220 -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ---MF--------------------------------------------- ----------------------------------------RKARRVNVRK RNDSEEEE-------RE--------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -----xxGxxxxxxxxxRKRPRENKE--VP-------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ----------RAS-----------------------------------LL SF-QDE-EE-EN-------------------------------------- -----------------------------------------------E-- ------EVFKVKKSSYSKKIVKLLKKEYKE-------------------- --------------------------------DLEKSK------------ -------------------------------------------------- -------------------------------------------------- -IKNELN-----------S------------------------------- ---------SADNEQSLDKTGHVKDTNPEDGVIISEHGEDEMDMES---- EKEEE--------------------------------------------- ---------KPKA-GGTFS------------------------------- ---------------------------NTLSSLNVLRP-----------G EIPDAAFIHAARKKRQMARELGDFTP-HDNE-PGKGRLVR-ED--ENDA- SD-DEDDDEKRRIVFSVKEKSQRQKIAEE--I---GIEGSDDDALV-TGE QDEELSRWEQEQIRKGINIPQVQASQPAEV-NMYYQNTYQTMPYSSSYGI PYSY--TAY-----------------------------GSS-DAKSQKTD NTVPFKTPSNEMTPVTIDLVKKQLKD-R---------------------- ------------------------------------------LDSVKDLH RTNRQQHEKHLQSRVDSTRAIERLEGSSGGIGERYKFLQEMRGYVQDLLE CFSEKVPLINELESAIHQLYKQRASRLVQRRQDDIKDESSEFSSHS---- ---------------NKALMAPNLDSFGRDRALYQEHAK-RRIAERE--- ---ARR-TRR-RQAREQTGKMADHLEGLSSDDEETSTDITNFNLEK--DR ISKESSKVFEDVLESFYSIDCIKSQFEAWRSKYYMSYKDAYIGLCLPKLF NPLIRLQLLTWTPLE----------------------------------- -AKCRDFENMLWFESLLFYGCEEQE--QEKDDVDVALLPTIVEKVILPKL TVIAENMWDPFSTT--------------QTSRMVGITLKLINGYPSVVNA ENKN-----TQVYLKALLLRMRRTLDDDVFMPLYPKNVLENKNSGPYLFF QRQFWSSVKLLGNFLQWYGIFSNKTLQELSIDGLLNRYILMAFQNSEYGD DSIKKAQNVINCFPKQWFVNLKGERTISQLENFCRYLVHLADTIYRNSIG CSDVEKRNARENIKQIVKLLASVRALDHAMSVASDH-------------- --N------------VKEVKSLIEGK-- >ENSBTAP00000003986 -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ---MF--------------------------------------------- ----------------------------------------RKARRVNVRK RNDSEEEE-------RER-------------------------------- -----------------------------------DEExx---------- ------------------------------xx------------------ -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- --------------x----------------------------------- -------------------------------------------------- -xx----------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- --------xx---------------------------------------- -------------------------------------------------- ----------------------------------------x--------- -------------------------------------------------- -------------------------------------------------- --xxx-----------xxx------------------------------- ----------------------------------------xxxxxxxx-- ------xxx----------------------------------------- -------------------------------------------------- -------------------------------------------------- -----x-------------------------------------------- ---------------xxExx------------------------------ ----------------------------------------------xxxx xx----x-----xxxxx--------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ------------------------------------------xxxxxxxx xxxxxxxGxxxxxxxxxRKRPRENKE--VP-------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ----------RAS-----------------------------------LL SF-QDE-DE-EN-------------------------------------- -----------------------------------------------E-- ------EVFKVKKSSYSKKIVKLLKKEYKE-------------------- --------------------------------DLEKSK------------ -------------------------------------------------- -------------------------------------------------- -IKTELN-----------S------------------------------- ---------SADNEPPLDKAGHVKDTSLEDGVIISEHGEDEMDMES---- EKEEE--------------------------------------------- ---------KPKA-GGAFS------------------------------- ---------------------------NALSSLNVLRP-----------G EIPDAAFIHAARKKRQMARELGDFTP-HDSE-PGKGRLVR-ED--ENDA- SD-DEDDDEKRRIVFSVKEKSQRQKIAEE--I---GIEGSDDDALV-TGE QDEELSRWEQEQIRKGINIPQVQASQPTEV-NMYYQNTYQTMPYGSSYGI PYSY--SAY-----------------------------GSS-DAKSQKTD NTVPFKTPSNEMTPVTIDLVKKQLKD-R---------------------- ------------------------------------------LDSMKELH KTNRQQHEKHLQSRADSTRAIERLEGSSGGIGERYKFLQEMRGYVQDLLE CFSEKVPLINELESAIHQLYKQRASRLVQRRQDDIKDESSEFSSHS---- ---------------NKALMAPNLDSFGRDRALYQEHAK-RRIAERE--- ---ARR-TRR-RQAREQTGKMADHLEGLSSDDEETSTDITNFNLEK--DR ISKESSKVFEDVLESFYSIDCIKSQFEAWRSKYYTSYKHAYIGLCLPKLL NPLIRLQLLTWTPLE----------------------------------- -AKCRDFENMLWFESLLFYGCEERE--QEKDDVDVALLPTIVEKVILPKL TVIAENMWDPFSTT--------------QTSRMVGITLKLINGYPSVVNA ENKN-----TQVYLKALLLRMRRTLDDDVFMPLYPKNVLENKNSGPYLFF QRQFWSSVKLLGNFLQWYGIFSNKTLQELSIDGLLNRYILMAFQNSEYGD DSIKKAQNVINCFPKQWFVNLKGERTISQLENFCRYLVHLADTIYRNSIG CSDVEKRNARENIKQIVKLLASVRALDHAMSVASDH-------------- --N------------VKEFKSLIEGK-- >ENSBIXP00000042233 -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ---MF--------------------------------------------- ----------------------------------------RKARRVNVRK RNDSEEEE-------RER-------------------------------- -----------------------------------DEExx---------- ------------------------------xx------------------ -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- --------------x----------------------------------- -------------------------------------------------- -xx----------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- --------xx---------------------------------------- -------------------------------------------------- ----------------------------------------x--------- -------------------------------------------------- -------------------------------------------------- --xxx-----------xxx------------------------------- ----------------------------------------xxxxxxxx-- ------xxx----------------------------------------- -------------------------------------------------- -------------------------------------------------- -----x-------------------------------------------- ---------------xxExx------------------------------ ----------------------------------------------xxxx xx----x-----xxxxx--------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ------------------------------------------xxxxxxxx xxxxxxxGxxxxxxxxxRKRPRENKE--VP-------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ----------RAS-----------------------------------LL SF-QDE-DE-EN-------------------------------------- -----------------------------------------------E-- ------EVFKVKKSSYSKKIVKLLKKEYKE-------------------- --------------------------------DLEKSK------------ -------------------------------------------------- -------------------------------------------------- -IKTELN-----------S------------------------------- ---------SADNEPPLDKAGHVKDTSLEDGVIISEHGEDEMDMES---- EKEEE--------------------------------------------- ---------KPKA-GGAFS------------------------------- ---------------------------NALSSLNVLRP-----------G EIPDAAFIHAARKKRQMARELGDFTP-HDSE-PGKGRLVR-ED--ENDA- SD-DEDDDEKRRIVFSVKEKSQRQKIAEE--I---GIEGSDDDALV-TGE QDEELSRWEQEQIRKGINIPQVQASQPTEV-NMYYQNTYQTMPYGSSYGI PYSY--SAY-----------------------------GSS-DAKSQKTD NTVPFKTPSNEMTPVTIDLVKKQLKD-R---------------------- ------------------------------------------LDSMKELH KTNRQQHEKHLQSRADSTRAIERLEGSSGGIGERYKFLQEMRGYVQDLLE CFSEKVPLINELESAIHQLYKQRASRLVQRRQDDIKDESSEFSSHS---- ---------------NKALMAPNLDSFGRDRALYQEHAK-RRIAERE--- ---ARR-TRR-RQAREQTGKMADHLEGLSSDDEETSTDITNFNLEK--DR ISKESSKVFEDVLESFYSIDCIKSQFEAWRSKYYTSYKHAYIGLCLPKLL NPLIRLQLLTWTPLE----------------------------------- -AKCRDFENMLWFESLLFYGCEERE--QEKDDVDVALLPTIVEKVILPKL TVIAENMWDPFSTT--------------QTSRMVGITLKLINGYPSVVNA ENKN-----TQVYLKALLLRMRRTLDDDVFMPLYPKNVLENKNSGPYLFF QRQFWSSVKLLGNFLQWYGIFSNKTLQELSIDGLLNRYILMAFQNSEYGD DSIKKAQNVINCFPKQWFVNLKGERTISQLENFCRYLVHLADTIYRNSIG CSDVEKRNARENIKQIVKLLASVRALDHAMSVASDH-------------- --N------------VKEFKSLIEGK-- >ENSBMUP00000010819 -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ---MF--------------------------------------------- ----------------------------------------RKARRVNVRK RNDSEEEE-------RER-------------------------------- -----------------------------------DEExx---------- ------------------------------xx------------------ -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- --------------x----------------------------------- -------------------------------------------------- -xx----------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- --------xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx----------- ---------------------------------------x---------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -----------N-------------------------------------- -----------------------------------------------E-- ------EVFKVKKSSYSKKIVKLLKKEYKE-------------------- --------------------------------DLEKSK------------ -------------------------------------------------- -------------------------------------------------- -IKTELN-----------S------------------------------- ---------SADNEPPLDKAGHVKDTSLEDGVIISEHGEDEMDMES---- EKEEE--------------------------------------------- ---------KPKA-GGAFS------------------------------- ---------------------------NALSSLNVLRP-----------G EIPDAAFIHAARKKRQMARELGDFTP-HDSE-PGKGRLVR-ED--ENDA- SD-DEDDDEKRRIVFSVKEKSQRQKIAEE--I---GIEGSDDDALV-TGE QDEELSRWEQEQIRKGINIPQVQASQPTEV-NMYYQNTYQTMPYGSSYGI PYSY--SAY-----------------------------GSS-DAKSQKTD NTVPFKTPSNEMTPVTIDLVKKQLKD-R---------------------- ------------------------------------------LDSMKELH KTNRQQHEKHLQSRADSTRAIERLEGSSGGIGERYKFLQEMRGYVQDLLE CFSEKVPLINELESAIHQLYKQRASRLVQRRQDDIKDESSEFSSHS---- ---------------NKALMAPNLDSFGRDRALYQEHAK-RRIAERE--- ---ARR-TRR-RQAREQTGKMADHLEGLSSDDEETSTDITNFNLEK--DR ISKESSKVFEDVLESFYSIDCIKSQFEAWRSKYYTSYKHAYIGLCLPKLL NPLIRLQLLTWTPLE----------------------------------- -AKCRDFENMLWFESLLFYGCEERE--QEKDDVDVALLPTIVEKVILPKL TVIAENMWDPFSTT--------------QTSRMVGITLKLINGYPSVVNA ENKN-----TQVYLKALLLRMRRTLDDDVFMPLYPKNVLENKNSGPYLFF QRQFWSSVKLLGNFLQWYGIFSNKTLQELSIDGLLNRYILMAFQNSEYGD DSIKKAQNVINCFPKQWFVNLKGERTISQLENFCRYLVHLADTIYRNSIG CSDVEKRNARENIKQIVKLLASVRALDHAMSVASDH-------------- --N------------VKEFKSLIEGK-- >ENSBIXP00005045787 -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ---MF--------------------------------------------- ----------------------------------------RKARRVNVRK RNDSEEEE-------RER-------------------------------- -----------------------------------DEExx---------- ------------------------------xx------------------ -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- --------------x----------------------------------- -------------------------------------------------- -xx----------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- --------xx---------------------------------------- -------------------------------------------------- ----------------------------------------x--------- -------------------------------------------------- -------------------------------------------------- --xxx-----------xxxx-----xxx---------------------- ----------------------------------------xxxxxxxx-- ------xxx----------------------------------------- -------------------------------------------------- -------------------------------------------------- -----x-------------------------------------------- ---------------xxExx------------------------------ ----------------------------------------------xxxx x-----------xxxxx--------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ------------------------------------------xxxxxxxx xxxxxxxGxxxxxxxxxRKRPRENKE--VP-------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ----------RAS-----------------------------------LL SF-QDE-DE-EN-------------------------------------- -----------------------------------------------E-- ------EVFKVKKSSYSKKIVKLLKKEYKE-------------------- --------------------------------DLEKSK------------ -------------------------------------------------- -------------------------------------------------- -IKTELN-----------S------------------------------- ---------SADNEPPLDKAGHVKDTSLEDGVIISEHGEDEMDMES---- EKEEE--------------------------------------------- ---------KPKA-GGAFS------------------------------- ---------------------------NALSSLNVLRP-----------G EIPDAAFIHAARKKRQMARELGDFTP-HDSE-PGKGRLVR-ED--ENDA- SD-DEDDDEKRRIVFSVKEKSQRQKIAEE--I---GIEGSDDDALV-TGE QDEELSRWEQEQIRKGINIPQVQASQPTEV-NMYYQNTYQTMPYGSSYGI PYSY--SAY-----------------------------GSS-DAKSQKTD NTVPFKTPSNEMTPVTIDLVKKQLKD-R---------------------- ------------------------------------------LDSMKELH KTNRQQHEKHLQSRADSTRAIERLEGSSGGIGERYKFLQEMRGYVQDLLE CFSEKVPLINELESAIHQLYKQRASRLVQRRQDDIKDESSEFSSHS---- ---------------NKALMAPNLDSFGRDRALYQEHAK-RRIAERE--- ---ARR-TRR-RQAREQTGKMADHLEGLSSDDEETSTDITNFNLEK--DR ISKESSKVFEDVLESFYSIDCIKSQFEAWRSKYYTSYKHAYIGLCLPKLL NPLIRLQLLTWTPLE----------------------------------- -AKCRDFENMLWFESLLFYGCEERE--QEKDDVDVALLPTIVEKVILPKL TVIAENMWDPFSTT--------------QTSRMVGITLKLINGYPSVVNA ENKN-----TQVYLKALLLRMRRTLDDDVFMPLYPKNVLENKNSGPYLFF QRQFWSSVKLLGNFLQWYGIFSNKTLQELSIDGLLNRYILMAFQNSEYGD DSIKKAQNVINCFPKQWFVNLKGERTISQLENFCRYLVHLADTIYRNSIG CSDVEKRNARENIKQIVKLLASVRALDHAMSVASDH-------------- --N------------VKEFKSLIEGK-- >ENSBBBP00000009510 -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ---MF--------------------------------------------- ----------------------------------------RKARRVNVRK RNDSEEEE-------RER-------------------------------- -----------------------------------DEExx---------- ------------------------------xx------------------ -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- --------------x----------------------------------- -------------------------------------------------- -xx----------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- --------xx---------------------------------------- -------------------------------------------------- ----------------------------------------x--------- -------------------------------------------------- -------------------------------------------------- --xxx-----------xxxx-----xxxxxxxxxxxxxxxxxxxxxxxxx xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx--------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ---QDE-DE-EN-------------------------------------- -----------------------------------------------E-- ------EVFKVKKSSYSKKIVKLLKKEYKE-------------------- --------------------------------DLEKSK------------ -------------------------------------------------- -------------------------------------------------- -IKTELN-----------S------------------------------- ---------SADNEPPLDKAGHVKDTSLEDGVIISEHGEDEMDMES---- EKEEE--------------------------------------------- ---------KPKA-GGAFS------------------------------- ---------------------------NALSSLNVLRP-----------G EIPDAAFIHAARKKRQMARELGDFTP-HDSE-PGKGRLVR-ED--ENDA- SD-DEDDDEKRRIVFSVKEKSQRQKIAEE--I---GIEGSDDDALV-TGE QDEELSRWEQEQIRKGINIPQVQASQPTEV-NMYYQNTYQTMPYGSSYGI PYSY--SAY-----------------------------GSS-DAKSQKTD NTVPFKTPSNEMTPVTIDLVKKQLKD-R---------------------- ------------------------------------------LDSMKELH KTNRQQHEKHLQSRADSTRAIERLEGSSGGIGERYKFLQEMRGYVQDLLE CFSEKVPLINELESAIHQLYKQRASRLVQRRQDDIKDESSEFSSHS---- ---------------NKALMAPNLDSFGRDRALYQEHAK-RRIAERE--- ---ARR-TRR-RQAREQTGKMADHLEGLSSDDEETSTDITNFNLEK--DR ISKESSKIFEDVLESFYSIDCIKSQFEAWRSKYYTSYKHAYIGLCLPKLL NPLIRLQLLTWTPLE----------------------------------- -AKCRDFENMLWFESLLFYGCEERE--QEKDDVDVALLPTIVEKVILPKL TVIAENMWDPFSTT--------------QTSRMVGITLKLINGYPSVVNA ENKN-----TQVYLKALLLRMRRTLDDDVFMPLYPKNVLENKNSGPYLFF QRQFWSSVKLLGNFLQWYGIFSNKTLQELSIDGLLNRYILMAFQNSEYGD DSIKKAQNVINCFPKQWFVNLKGERTISQLENFCRYLVHLADTIYRNSIG CSDVEKRNARENIKQIVKLLASVRALDHAMSVASDH-------------- --N------------VKEFKSLIEGK-- >ENSCHIP00000023854 -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ---MF--------------------------------------------- ----------------------------------------RKARRVNVRK RNDSEEEE-------RER-------------------------------- -----------------------------------DEExx---------- ------------------------------xx------------------ -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- --------------x----------------------------------- -------------------------------------------------- -xx----------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- --------xx---------------------------------------- -------------------------------------------------- ----------------------------------------x--------- -------------------------------------------------- -------------------------------------------------- --xxx-----------xxxx-----xxx---------------------- ----------------------------------------xxxxxxxx-- ------xxx----------------------------------------- -------------------------------------------------- -------------------------------------------------- -----x-------------------------------------------- ---------------xxExx------------------------------ ----------------------------------------------xxxx x-----------xxxxx--------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ------------------------------------------xxxxxxxx xxxxxxxGxxxxxxxxxRKRPRENKE--VP-------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ----------RAS-----------------------------------LL SF-QDE-DE-ET-------------------------------------- -----------------------------------------------E-- ------EVFKVKKSSYSKKIVKLLKKEYKE-------------------- --------------------------------DLEKSK------------ -------------------------------------------------- -------------------------------------------------- -IKTELN-----------S------------------------------- ---------SADNEPPLDKAGHVKDASLEDGVIISEHGEDEMDMES---- EKEEE--------------------------------------------- ---------KPKA-GGAFS------------------------------- ---------------------------NALSSLNVLRP-----------G EIPDAAFIHAARKKRQMARELGDFTP-HDSE-PGKGRLVR-ED--ENDA- SD-DEDDDEKRRIVFSVKEKSQRQKIAEE--I---GIEGSDDDALV-TGE QDEELSRWEQEQIRKGINIPQVQASQPTEV-NVYYQNTYQTMPYGSSYGV PYSY--SAY-----------------------------GSS-DAKSQKPD NAVPFRTPSNEMPPVTIDLVKKQLKD-R---------------------- ------------------------------------------LDSMKELH KANRQQHEKHLQSRADSTRAIERLEGSSGGIGERYRFLQEMRGYVQDLLE CFSEKVPLINELESAIHQLYKQRASRLVQRRQDDIKDESSEFSSHS---- ---------------NKALMAPNLDSFGRDRALYQEHAK-RRIAERE--- ---ARR-TRR-RQAREQTGKMADHLEGLSSDDEETSTDITNFNLEK--DR ISKESSKVFEDVLESFYSIDCIKSQFEAWRSKYYTSYKHAYIGLCLPKLL NPLIRLQLLTWTPLE----------------------------------- -AKCRDFENMLWFESLLFYGCEERE--QEKDDVDVALLPTIVEKVILPKL TVIAENMWDPFSTT--------------QTSRMVGITLKLINGYPSVVNA ENKN-----TQIYLKALLLRMRRTLDDDVFMPLYPKNVLENKNSGPYLFF QRQFWSSVKLLGNFLQWYGIFSNKTLQELSIDGLLNRYILMAFQNSEYGD DSIKKAQNVINCFPKQWFVNLKGERTISQLENFCRYLVHLADTIYRNSIG CSDVEKRNARENIKQIVKLLASVRALDHAMSVASDH-------------- --N------------VKEFKSLIEGK-- >ENSOARP00000014297 -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ---MF--------------------------------------------- ----------------------------------------RKARRVNVRK RNDSEEEE-------RER-------------------------------- -----------------------------------DEExx---------- ------------------------------xx------------------ -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- --------------x----------------------------------- -------------------------------------------------- -xx----------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- --------xx---------------------------------------- -------------------------------------------------- ----------------------------------------x--------- -------------------------------------------------- -------------------------------------------------- --xxx-----------xxxx-----xxx---------------------- ----------------------------------------xx-------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- --------------xxx--------------------------------- ---------------------------------x---------------- --xxx--------------------------------------------- -------------------------------------------------- -------------------------------------------------- -----------------------------------------xxxxxxxxx xxxxxxxGxxxxxxxxxRKRPRENKE--VP-------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ----------RAS-----------------------------------LL SF-QDE-DE-ET-------------------------------------- -----------------------------------------------E-- ------EVFKVKKSSYSKKIVKLLKKEYKE-------------------- --------------------------------DLEKSK------------ -------------------------------------------------- -------------------------------------------------- -IKTELN-----------S------------------------------- ---------SADNEPPLDKAGHVKDASLEDGVIISEHGEDEMDMES---- EKEEE--------------------------------------------- ---------KPKA-GGAFS------------------------------- ---------------------------NALSSLNVLRP-----------G EIPDAAFIHAARKKRQMARELGDFTP-HDSE-PGKGRLVR-ED--ENDA- SD-DEDDDEKRRIVFSVKEKSQRQKIAEExAI---GIEGSDDDALV-TGE QDEELSRWEQEQIRKGINIPQVQASQPTEV-NMYYQNTYQTMPYGSSYGI PYSY--SAY-----------------------------GSS-DAKSQKTD NTVPFKTPSNEMTPVTIDLVKKQLKD-R---------------------- ------------------------------------------LDSMKELH KANRQQHEKHLQSRADSTRAIERLEGSSGGIGERYRFLQEMRGYVQDLLE CFSEKVPLINELESAIHQLYKQRASRLVQRRQDDIKDESSEFSSHS---- ---------------NKALMAPNLDSFGRDRALYQEHAK-RRIAERE--- ---ARR-TRR-RQAREQTGKMADHLEGLSSDDEETSTDITNFNLEKVLDR ISKESSKVFEDVLESFYSIDCIKSQFEAWRSKYYTSYKHAYIGLCLPKLL NPLIRLQLLTWTPLE----------------------------------- -AKCRDFENMLWFESLLFYGCEERE--QEKDDVDVALLPTIVEKVILPKL TVIAENMWDPFSTT--------------QTSRMVGITLKLINGYPSVVNA ENKN-----TQIYLKALLLRMRRTLDDDVFMPLYPKNVLENKNSGPYLFF QRQFWSSVKLLGNFLQWYGIFSNKTLQELSIDGLLNRYILMAFQNSEYGD DSIKKAQNVINCFPKQWFVNLKGERTISQLENFCRYLVHLADTIYRNSIG CSDVEKRNARENIKQIVKLLASVRALDHAMSVASDH-------------- --N------------VKEFKSLIEGK-- >ENSODEP00000003108 -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ---MF--------------------------------------------- ----------------------------------------RKARRVNVRK RNDSEEEE-------RER-------------------------------- -----------------------------------DDExx---------- ------------------------------xx------------------ -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- --------------x----------------------------------- -------------------------------------------------- -xx----------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- --------xx---------------------------------------- -------------------------------------------------- ----------------------------------------x--------- ----------xx-------------------------------------- -------------------------------------------------- ----------------xxxx-----xx----------------------- ---------------------------------------------xxx-- ------xxx----------------------------------------- -------------------------------------------------- -------------------------------------------------- -----x-------------------------------------------- ---------------xxExx------------------------------ ----------------------------------------------xxxx x-------------xLx--------------------------------- ---------------------------------xx-------------xx xxx----------------------------------------------- -------------------------------------------------- -------------------------------------------------- -----------------------------------------------xxx xxxxxxxGxxxxxxxxxRKRPRENKE--VP-------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ----------RAS-----------------------------------LL SF-QDE-EE-EN-------------------------------------- -----------------------------------------------E-- ------EVFKVKKSSYSKKIVKLLKKEYKE-------------------- --------------------------------DLEKSK------------ -------------------------------------------------- -------------------------------------------------- -IKNELN-----------S------------------------------- ---------SANNEQSLDKTGHVKDTNQEDGVIINDHGEDEMDMES---- EKEEE--------------------------------------------- ---------KPKA-GGAFS------------------------------- ---------------------------NALSSLNVLRP-----------G EIPDAAFIHAARKKRQMARELGDFTP-HDTE-PGKGRLVR-ED--ENDA- SD-DEDDDEKRRIVFSVKEKSQRQKIAEE--I---GIEGSDDDALV-TGE QDEELSRWEQEQIRKGINIPQVQASQPAEV-NMYYQNTYQTMPYGSSYGI PYSY--TAY-----------------------------GSS-DAKSQKTD NTVPFKTPSNEMTPVTIDLVKKQLKD-R---------------------- ------------------------------------------LDSMNELH KTNRQQHEKHLQSRVDSTRAIERLEGSSGGIGERYKFLQEMRGYVQDLLE CFSEKVPLINELESSIHQLYKQRASRLVQRRQDDIKDESSEFSSHS---- ---------------NKALMAPNLDSFGRDRALYQEHAK-RRIAERE--- ---ARR-TRR-RQAREQTGKMADHLEGLSSDDEETSTDITNFNLEK--DR ISKESSKVFEDVLESFYSIDCIKSQFEAWRSKYYTSYKDAYIGLCLPKLF NPLIRLQLLTWTPLE----------------------------------- -AKCRDFENMLWFESLLFYGCEERE--QEKDDVDVALLPTIVEKVILPKL TVIAENMWDPFSTT--------------QTSRMVGITLKLINGYPSVVNA ENKN-----TQVYLKALLLRMRRTLDDDVFMPLYPKHVLENKNSGPYLFF QRQFWSSVKLLGNFLQWYGIFSNKTLQELSIDGLLNRYILMAFQNSEYGD DSIKKAQNVINCFPKQWFMNLKGERTISQLENFCRYLVHLADTIYRNSIG CSDVEKRNARENIKQIVKLLASVRALDHAMSVASDH-------------- --N------------VKEFKSLIEGK-- >ENSCLAP00000010799 -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ---MF--------------------------------------------- ----------------------------------------RKARRVNVRK RNDSEEEE-------RER-------------------------------- -----------------------------------DEExx---------- ------------------------------xx------------------ -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- --------------x----------------------------------- -------------------------------------------------- -xx----------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- --------xx---------------------------------------- -------------------------------------------------- ----------------------------------------x--------- ----------xx-------------------------------------- -------------------------------------------------- ----------------xxxx-----xx----------------------- ---------------------------------------------xxx-- ------xxx----------------------------------------- -------------------------------------------------- -------------------------------------------------- -----x-------------------------------------------- ---------------xxExx------------------------------ ----------------------------------------------xxxx -------------------------------------------------- ----------------------------------x-------------xx xxx----------------------------------------------- -------------------------------------------------- -------------------------------------------------- -----------------------------------------------xxx xxxxxxxGxxxxxxxxxRKRPRENKE--VP-------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ----------RAS-----------------------------------LL SF-QDE-EE-EN-------------------------------------- -----------------------------------------------E-- ------EVFKVKKSSYSKKIVKLLKKEYKE-------------------- --------------------------------DLEKSK------------ -------------------------------------------------- -------------------------------------------------- -IKNELN-----------S------------------------------- ---------SANNEQSLDKTGHVKDTNQEDGVIINDHGEDEMDMES---- EKEEE--------------------------------------------- ---------KPKA-GGAFS------------------------------- ---------------------------NALSSLNVLRP-----------G EIPDAAFIHAARKKRQMARELGDFTP-HDNE-PGKGRLVR-ED--ENDA- SD-DEDDDEKRRIVFSVKEKSQRQKIAEE--I---GIEGSDDDALV-TGE QDEELSRWEQEQIRKGINIPQVQASQPTEV-NMYYQNTYQTMPYGSSYGI PYSY--TAY-----------------------------GSS-DAKSQKTD NSVPFKTPSNEMTPVTIDLVKKQLKD-R---------------------- ------------------------------------------LDSMKELH KTNRQQHEKHLQSRVDSTRAIERLEGSSGGIGERYKFLQEMRGYVQDLLE CFSEKVPLINELESSIHQLYKQRASRLVQRRQDDIKDESSEFSSHS---- ---------------NKALMAPNLDSFGRDRALYQEHAK-RRIAERE--- ---ARR-TRR-RQAREQTGKMADHLEGLSSDDEETSTDITNFNLEK--DR ISKESSKVFEDVLESFYSIDCIKSQFEAWRSKYYTSYKDAYIGLCLPKLF NPLIRLQLLTWTPLE----------------------------------- -AKCRDFENMLWFESLLFYGCEERE--QEKEDVDVALLPTIVEKVILPKL TVIAENMWDPFSTT--------------QTSRMVGITLKLINGYPSVVNA ENKN-----TQVYLKALLLRMRRTLDDDVFMPLYPKNVLENKNSGPYLFF QRQFWSSVKLLGNFLQWYGIFSNKTLQELSIDGLLNRYILMAFQNSEYGD DSIKKAQHVINCFPKQWFVNLKGERTITQLENFCRYLVHLADTIYRNSIG CSDVEKRNARENIKQIVKLLASVRALDHAMSVASDH-------------- --N------------VKEFKSLIEGK-- >ENSSSCP00000012819 -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ---MF--------------------------------------------- ----------------------------------------RKARRVNVRK RNDSEEEE-------RER-------------------------------- -----------------------------------DEExx---------- ------------------------------xx------------------ -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- --------------x----------------------------------- -------------------------------------------------- -xx----------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- --------xx---------------------------------------- -------------------------------------------------- ----------------------------------------x--------- ----------xx-------------------------------------- -------------------------------------------------- ----------------xxxx-----xxx---------------------- -------------------------------------------------- ------xxx----------------------------------------- -------------------------------------------------- -------------------------------------------------- -----x-------------------------------------------- ---------------xxExx------------------------------ ----------------------------------------------xxxx x------------xxPx--------------------------------- ---------------------------------xx-------------xx xxx----------------------------------------------- -------------------------------------------------- -------------------------------------------------- -----------------------------------------------xxx xxxxxxxGxxxxxxxxxRKRPRENKE--VP-------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ----------RAS-----------------------------------LL SF-QDE-DE-EN-------------------------------------- -----------------------------------------------E-- ------EVFKVKKSSYSKKIVKLLKKEYKE-------------------- --------------------------------DLEKSK------------ -------------------------------------------------- -------------------------------------------------- -IKTELN-----------S------------------------------- ---------LADNELPLDKTGHVKDASQEDGVIISEHGEDEMDMES---- EKEEE--------------------------------------------- ---------KPKA-GGTFS------------------------------- ---------------------------NALSSLNVLRP-----------G EIPDAAFIHAARKKRQMARELGDFTP-HDNE-PGKGRLVR-ED--ENDA- SD-DEDDDEKRRIVFSVKEKSQRQKIAEE--I---GIEGSDDDALV-AGE QDEELSRWEQEQIRKGINIPQVQASQPTEV-NMYYPNTYQTMPYGSSYGI PYSY--TAY-----------------------------GSS-DAKSQKTD NTVPFKTPSNEMTPVTIDLVKKQLKD-R---------------------- ------------------------------------------LDSMKELH KTNRQQHEKHLQSRVDSTRAIERLEGSSGGIGERYKFLQEMRGYVQDLLE CFSEKVPLINELESAIHQLYKQRASRLVQRRQDDIKDESSEFSSHS---- ---------------NKALMAPNLDSFGRDRALYQEHAK-RRIAERE--- ---ARR-TRR-RQAREQTGKMADHLEGLSSDDEETSTDITNFNLEK--DR ISKESSKVFEDVLESFYSIDCIKSQFEAWRSKYYMSYKDAYIGLCLPKLF NPLIRLQLLTWTPLE----------------------------------- -AKCRDFENMLWFESLLFYGCEERE--QEKDDVDVALLPTIVEKVILPKL TVIAENMWDPFSTT--------------QTSRMVGITLKLINGYPSVVNA ENKN-----TQVYLKALLLRMRRTLDDDVFMPLYPKNVLENKNSGPYLFF QRQFWSSVKLLGNFLQWYGIFSNKTLQELSIDGLLNRYILMAFQNSEYGD DSIKKAQNVINCFPKQWFMNLKGERTISQLENFCRYLVHLADTIYRNSIG CSDVEKRNARENIKQIVKLLASVRALDHALSVASDH-------------- --N------------VKEFKSLIEGK-- >ENSTTRP00000002109 -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ---MF--------------------------------------------- ----------------------------------------RKARRVNVRK RNDSEEEE-------RER-------------------------------- -----------------------------------DEExx---------- ------------------------------xx------------------ -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- --------------x----------------------------------- -------------------------------------------------- -xx----------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- --------xx---------------------------------------- -------------------------------------------------- ----------------------------------------x--------- ----------xx-------------------------------------- -------------------------------------------------- ----------------xxxx-----xx----------------------- ---------------------------------------------xxx-- ------xxx----------------------------------------- -------------------------------------------------- -------------------------------------------------- -----x-------------------------------------------- ---------------xxExx------------------------------ ----------------------------------------------xxxx x-------------xPx--------------------------------- ---------------------------------xx-------------xx xxx----------------------------------------------- -------------------------------------------------- -------------------------------------------------- -----------------------------------------------xxx xxxxxxxGxxxxxxxxxRKRPRENKE--VP-------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ----------RAS-----------------------------------LL SF-QDE-DE-ES-------------------------------------- -----------------------------------------------E-- ------EVFKVKKSSYSKKIVKLLKKEYKE-------------------- --------------------------------DLEKSK------------ -------------------------------------------------- -------------------------------------------------- -IKTEIN-----------S------------------------------- ---------SADSEPPLDKTGHVKDTSQEDGVIISEHGEDEMDMES---- EKEEE--------------------------------------------- ---------KPKA-AGAFS------------------------------- ---------------------------NALSSLNVLRP-----------G EIPDAAFIHAARKKRQMARELGDFTP-HDSE-PGKGRLVR-ED--ENDA- SD-DEDDDEKRRIVFSVKEKSQRQKIAEE--I---GIEGSDDDALV-TGE QDEELSRWEQEQIRKGINIPQVQASQPTEV-NMYYQNTYQTMPYGSSYGI PYSY--TAY-----------------------------GSS-DAKSQKTD NTVPFKTPSNEMTPVTIDLVKKQLKD-R---------------------- ------------------------------------------LDSMKELH KTNRQQHEKHLQSRVDSTRAIERLEGSSGGIGERYKFLQEMRGYVQDLLE CFSEKVPLINELESAIHQLYKQRASRLVQRRQDDIKDESSEFSSHS---- ---------------NKALMAPNLDSFGRDRALYQEHAK-RRIAERE--- ---ARR-TRR-RQAREQTGKMADHLEGLSSDDEETSTDITNFNLEK--DR ISKESSKVFEDVLESFCSIDCIKSQFEAWRSKYYTSYKDAYIGLCLPKLF NPLI-LQLLTWTPLE----------------------------------- -AKCRDFENMLWFESLLFYGCEERE--QEKDDVDVALLPTIVEKVILPKL TVIAENMWDPFSTT--------------QTSRMVGITLKLINGYPSVVNA ENKN-----TQVYLKALLLRMRRTLDDDVFMPLYPKNVLENKNSGPYLFF QRQFWSSVKLLGNFLQWYGIFSNKTLQELSIDGLLNRYILMAFQNSEYGD DSIKKAQNVISCFPKQWFMNLKGERTISQLENFCRYLVHLADTIYRNSIG CSDVEKRNARENIKQIVKLLASVRALDHAMSVASDH-------------- --N------------VKEFKSLIEGK-- >ENSLAFP00000010677 -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ----------EN-------------------------------------- -----------------------------------------------E-- ------EVFKVKKSSYSKKIVKLLKKEYKE-------------------- --------------------------------DLEKSK------------ -------------------------------------------------- -------------------------------------------------- -IKTELN-----------S------------------------------- ---------SADNEQPLDKTGHVKDPNQEDGVIISEHGEDEMDMES---- EKEEE--------------------------------------------- ---------KPKA-GGAFS------------------------------- ---------------------------NALSSLNVLRP-----------G EIPDAAFIHAARKKRQMARELGDFTP-HDSE-PGKGRLVR-ED--ENDA- SD-DEDDDEKRRIVFSVKEKSQRQKIAEE--I---GIEGSDDEALV-TGD QDEELSRWEQEQIRKGINIPQVQASQPTEV-NMYYQSSYQTMPYGSSYGI PYSY--AAY-----------------------------GSS-DAKSQKSD NTVPFKTPSNEMTPVTIDLVKKQLKD-R---------------------- ------------------------------------------LDSMKELH KTNRQQHEKHLQSRVDSTRAIERLEGSSGGIGERYKFLQEMRGYVQDLLE CFSEKVPLINELESAIHQLYKQRASRLVQRRQDDIKDESSEFSSHS---- ---------------NKALMAPNLDSFGRDRALYQEHAK-RRIAERE--- ---ARR-TRR-RQAREQTGKMADHLEGLSSDDEETSTDITNFNLEK--DR ISKESSKIFEDVLESFCSIDCIKSQFEAWRSKYYRSYKDAYIGLCLPKLF NPLIRLQLLTWTPLE----------------------------------- -AKCRDFESMLWFESLLFYGCEERE--QEKDDVDVALLPTIVEKVILPKL TAIAENMWDPFSTT--------------QTSRMVGITLKLINGYSSVVNA ENKS-----TQVYLKALLLRMRRTLDDDVFMPLYPKNVLENKNSGPYLFF QRQFWSSVKLLGNFLQWYGIFSNKTLQELSIDGLLNRYILMAFQNSEYGD DSIKKAQNVINCFPKQWFVNLKGERTISQLENFCRYLVHLADTIYRNSIG CSDVEKRNARENIKQIIKLLASVRALDHALSVATDH-------------- --N------------VKEFKSLIEGK-- >ENSHGLP00000016512 -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ---MF--------------------------------------------- ----------------------------------------RKARRVNVRK RNDSEEEE-------RER-------------------------------- -----------------------------------DEDxx---------- ------------------------------xx------------------ -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- --------------x----------------------------------- -------------------------------------------------- -xx----------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- --------xx---------------------------------------- -------------------------------------------------- ----------------------------------------x--------- ----------xx-------------------------------------- -------------------------------------------------- ----------------xxxx-----xx----------------------- ---------------------------------------------xxx-- ------xxx----------------------------------------- -------------------------------------------------- -------------------------------------------------- -----x-------------------------------------------- ---------------xxExx------------------------------ ----------------------------------------------xxxx x-------------xPx--------------------------------- ---------------------------------xx-------------xx xxx----------------------------------------------- -------------------------------------------------- -------------------------------------------------- -----------------------------------------------xxx xxxxxxxGxxxxxxxxxRKRPRENKE--VP-------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ----------RAS-----------------------------------LL SF-QDE-EE-EN-------------------------------------- -----------------------------------------------E-- ------EVFKVKKSSYSKKIVKLLKKEYKE-------------------- --------------------------------DLEKSK------------ -------------------------------------------------- -------------------------------------------------- -IKNELN-----------S------------------------------- ---------SADNEQSLDKTGHVKDTNQEDGVIx-EHGEDEMDMES---- EKEED--------------------------------------------- ---------KLKG-AGAFS------------------------------- ---------------------------NALSSLNVLRP-----------G EIPDAAFIHAARKKRQMARELGDFTP-HDNE-PGKGRLVR-ED--ENDA- SD-DEDDDEKRRIVFSVKEKSQRQKIAEE--I---GIEGSDDDALV-TGE QDEELSRWEQEQIRKGINIPQVQASQPAEV-NMYYQNTYQTMPYGSSYGI PYSY--TAY-----------------------------GSS-DAKSQKTD NTVPFKTPSNEMTPVTIDLVKKQLKD-R---------------------- ------------------------------------------LDSMKELH RTNRQQHEKHLQSRVDSTRAIERLEGSSGGIGERYKFLQEMRGYVQDLLE CFSEKVPLINELESAIHQLYKQRASRLVQRRQDDIKDESSEFSSHS---- ---------------NKALMAPNLDSFGRDRALYQEHAK-RRIAERE--- ---ARR-TRR-RQAREQTGKMSDHLEGLSSDDEETSTDITNFNLEK--DR ISKESSKVFEDVLESFYSIDCIKLQFEAWRSKYYTSYKDAYIGLCLPKLF NPLIRLQLLTWTPLE----------------------------------- -AKCRDFENMLWFESLLFYGCEERE--QEKDDVDVALLPTIVEKVILPKL TVIAENMWDPFSTT--------------QTSRMVGITLKLINGYPSVANA ENKN-----TQVYLKALLLRMRRTLDDDVFMPLYPKNVLENKNSGPYLFF QRQFWSSVKLLGNFLQWYGIFSNKTLQELSIDGLLNRYILMAFQNSEYGD DSIKKAQNVMNCFPKQWFVNLKGERTISQLENFCRYLVHLADTIYRNSIG CSDVEKRNARENIKQIVKLLASVRALDHAMSVASDH-------------- --N------------VKEFKSLIEGK-- >ENSHGLP00100013953 -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ---MF--------------------------------------------- ----------------------------------------RKARRVNVRK RNDSEEEE-------RER-------------------------------- -----------------------------------DEDxx---------- ------------------------------xxxxxxx------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------x------------------------------------ -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- xxx----------------------------------------------- -------------------------------------------------- -------------------------------------------------- -----------------------------------------------xxx xxxxxxxGxxxxxxxxxRKRPRENKE--VP-------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ----------RAS-----------------------------------LL SF-QDE-EE-EN-------------------------------------- -----------------------------------------------E-- ------EVFKVKKSSYSKKIVKLLKKEYKE-------------------- --------------------------------DLEKSK------------ -------------------------------------------------- -------------------------------------------------- -IKNELN-----------S------------------------------- ---------SADNEQSLDKTGHVKDTNQEDGVIx-EHGEDEMDMES---- EKEED--------------------------------------------- ---------KLKG-AGAFS------------------------------- ---------------------------NALSSLNVLRP-----------G EIPDAAFIHAARKKRQMARELGDFTP-HDNE-PGKGRLVR-ED--ENDA- SD-DEDDDEKRRIVFSVKEKSQRQKIAEE--I---GIEGSDDDALV-TGE QDEELSRWEQEQIRKGINIPQVQASQPAEV-NMYYQNTYQTMPYGSSYGI PYSY--TAY-----------------------------GSS-DAKSQKTD NTVPFKTPSNEMTPVTIDLVKKQLKD-R---------------------- ------------------------------------------LDSMKELH RTNRQQHEKHLQSRVDSTRAIERLEGSSGGIGERYKFLQEMRGYVQDLLE CFSEKVPLINELESAIHQLYKQRASRLVQRRQDDIKDESSEFSSHS---- ---------------NKALMAPNLDSFGRDRALYQEHAK-RRIAERE--- ---ARR-TRR-RQAREQTGKMSDHLEGLSSDDEETSTDITNFNLEK--DR ISKESSKVFEDVLESFYSIDCIKLQFEAWRSKYYTSYKDAYIGLCLPKLF NPLIRLQLLTWTPLE----------------------------------- -AKCRDFENMLWFESLLFYGCEERE--QEKDDVDVALLPTIVEKVILPKL TVIAENMWDPFSTT--------------QTSRMVGITLKLINGYPSVVNA ENKN-----TQVYLKALLLRMRRTLDDDVFMPLYPKNVLENKNSGPYLFF QRQFWSSVKLLGNFLQWYGIFSNKTLQELSIDGLLNRYILMAFQNSEYGD DSIKKAQNVMNCFPKQWFVNLKGERTISQLENFCRYLVHLADTIYRNSIG CSDVEKRNARENIKQIVKLLASVRALDHAMSVASDH-------------- --N------------VKEFKSLIEGK-- >ENSPPAP00000022824 x-------------------xxxxxxxxxxxxxxxxxxxxxxx------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -----------xxxxxxRKRPRENKE--VP-------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ----------RAS-----------------------------------LL SF-QDE-EE-EN-------------------------------------- -----------------------------------------------E-- ------EVFKVKKSSYSKKIVKLLKKEYKE-------------------- --------------------------------DLEKSK------------ -------------------------------------------------- -------------------------------------------------- -IKTELN-----------S------------------------------- ---------SAESEQPLDKTGHVKDTNQEDGVIISEHGEDEMDMES---- EKEEE--------------------------------------------- ---------KPKT-GGAFS------------------------------- ---------------------------NALSSLNVLRP-----------G EIPDAAFIHAARKKRQMARELGDFTP-HDNE-PGKGRLVR-ED--ENDA- SD-DEDDDEKRRIVFSVKEKSQRQKIAEE--I---GIEGSDDDALV-TGE QDEELSRWEQEQIRKGINIPQVQASQPAEV-NMYYQNTYQTMPYGSTYGI PYSY--TAY-----------------------------GSS-DAKSQKTD NTVPFKTPSNEMTPVTIDLVKKQLKD-R---------------------- ------------------------------------------LDSMKELH KTNRQQHEKHLQSRVDSTRAIERLEGSSGGIGERYKFLQEMRGYVQDLLE CFSEKVPLINELESAIHQLYKQRASRLVQRRQDDIKDESSEFSSHS---- ---------------NKALMAPNLDSFGRDRALYQEHAK-RRIAERE--- ---ARR-TRR-RQAREQTGKMADHLEGLSSDDEETSTDITNFNLEK--DR ISKESGKVFEDVLESFYSIDCIKSQFEAWRSKYYTSYKDAYIGLCLPKLF NPLIRLQLLTWTPLE----------------------------------- -AKCRDFENMLWFESLLFYGCEERE--QEKDDVDVALLPTIVEKVILPKL TVIAENMWDPFSTT--------------QTSRMVGITLKLINGYPSVVNA ENKN-----TQIYLKALLLRMRRTLDDDVFMPLYPKNVLENKNSGPYLFF QRQFWSSVKLLGNFLQWYGIFSNKTLQELSIDGLLNRYILMAFQNSEYGD DSIKKAQNVINCFPKQWFMNLKGERTISQLENFCRYLVHLADTIYRNSIG CSDVEKRNARENIKQIVKLLASVRALDHAMSVASDH-------------- --N------------VKEFKSLIEGK-- >ENSSBOP00000027527 -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ---x---------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -----------------xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx x------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- --------------xxx--------------------------------- ---------------------------------xx-------------xx xxx----------------------------------------------- -------------------------------------------------- -------------------------------------------------- -----------------------------------------------xxx xxxxxxxGxxxxxxxxxRKRPRENKE--VP-------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ----------RAS-----------------------------------LL SF-QDE-EE-EN-------------------------------------- -----------------------------------------------E-- ------EVFKVKKSSYSKKIVKLLKKEYKE-------------------- --------------------------------DLEKSK------------ -------------------------------------------------- -------------------------------------------------- -IKTELN-----------S------------------------------- ---------SAESEQPLDKTGHVKDTNQEDGVIISEHGEDEMDMES---- EKEEE--------------------------------------------- ---------KPKT-GGAFS------------------------------- ---------------------------NALSSLNVLRP-----------G EIPDAAFIHAARKKRQMARELGDFTP-HDNE-PGKGRLVR-ED--ENDA- SD-DEDDDEKRRIVFSVKEKSQRQKIAEE--I---GIEGSDDDALV-TGE QDEELSRWEQEQIRKGINIPQVQASQPAEV-NMYYQNTYQTMPYGSSYGI PYSY--TAY-----------------------------GSS-DAKSQKTD NTVPFKTPSNEMTPVTIDLVKKQLKD-R---------------------- ------------------------------------------LDSMKELH KTNRQQHEKHLQSRVDSTRAIERLEGSSGGIGERYKFLQEMRGYVQDLLE CFSEKVPLINELESAIHQLYKQRASRLVQRRQDDIKDESSEFSSHS---- ---------------NKALMAPNLDSFGRDRALYQEHAK-RRIAERE--- ---ARR-TRR-RQAREQTGKMADHLEGLSSDDEETSTDITNFNLEK--DR ISKESSKVFEDVLESFYSIDCIKSQFEAWRSKYYTSYKDAYIGLCLPKLF NPLIRLQLLTWTPLE----------------------------------- -AKCRDFENMLWFESLLFYGCEERE--QEKDDVDVALLPTIVEKVILPKL TVIAENMWDPFSTT--------------QTSRMVGITLKLINGYPSVVNA ENKN-----TQVYLKALLLRMRRTLDDDVFMPLYPKNVLENKNSGPYLFF QRQFWSSVKLLGNFLQWYGIFSNKTLQELSIDGLLNRYILMAFQNSEYGD DSIKKAQNVINCFPKQWFMHLKGERTISQLENFCRYLVHLADTIYRNSIG CSDVEKRNARENIKQIVKLLASVRALDHAMSVASEH-------------- --N------------VKEFKSLIEGK-- >ENSJJAP00000002423 -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ---MF--------------------------------------------- ----------------------------------------RKARRVNVRK RNDSEEEE-------RER-------------------------------- -----------------------------------DEExx---------- ------------------------------xx------------------ -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- --------------x----------------------------------- -------------------------------------------------- -xx----------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- --------xx---------------------------------------- -------------------------------------------------- ----------------------------------------x--------- ----------xx-------------------------------------- -------------------------------------------------- ----------------xxxx-----xx----------------------- ---------------------------------------------xxx-- ------xxx----------------------------------------- -------------------------------------------------- -------------------------------------------------- -----x-------------------------------------------- ---------------xxExx------------------------------ ----------------------------------------------xxxx x-------------xPx--------------------------------- ---------------------------------xx-------------xx xxx----------------------------------------------- -------------------------------------------------- -------------------------------------------------- -----------------------------------------------xxx xxxxxxxGxxxxxxxxxRKRPRENKE--VP-------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ----------RAS-----------------------------------LL SF-QDE-EE-EN-------------------------------------- -----------------------------------------------E-- ------EVFKVKKSSYSKKIVKLLKKEYKE-------------------- --------------------------------DLEKSK------------ -------------------------------------------------- -------------------------------------------------- -VKTELD-----------S------------------------------- ---------TVGNDQPVDKTGHVKDTNQEDGVLIGEHGEDEMDMES---- EKEEE--------------------------------------------- ---------KPKA-GGAFS------------------------------- ---------------------------NALSSLNVLRP-----------G EIPDAAFIHAARKKRQMARELGDFTP-HDNE-PGKGRLVR-ED--ENDA- SD-DDDDDEKRRIVFSVKEKSQRQKIAEE--I---GIEGSDDDALV-TGE QDEELSRWEQEQIRKGINIPQVQASQPNEV-NMYYQNTYQTMPYGSSYGI PYSY--TAY-----------------------------GSS-DAKSQKTD NTVPFKTPSNEMTPVTIDLVKKQLKD-R---------------------- ------------------------------------------LDSMKELH KTNRQQHEKHLQSRVDSTRAIERLEGSSGGIGERYKFLQEMRGYVQDLLE CFSEKVPLINELESAIHQLYKQRASRLVQRRQDDIKDESSEFSSHS---- ---------------NKALMAPNLDSFGRDRALYQEHAK-RRIAERE--- ---ARR-TRR-RQAREQTGKMADHLEGLSSDDEETSTDITNFNLEK--DR IAKESSKVFEDVLESFYSIDCIKSQFEAWRSKYYTSYKDAYIGLCLPKLF NPLIRLQLLTWTPLE----------------------------------- -AKCRDFENMLWFESLLFYGCEERE--QEKDDVDVALLPTIVEKVILPKL TVIAENMWDPFSTT--------------QTSRMVGITLKLINGYPSVVNA ENKN-----TQAYLKALLLRMRRTLDDDVFMPLYPKNVLENKNSGPYLFF QRQFWSSVKLLGNFLQWYGIFSNKTLQELSIDGLLNRYILMAFQNSEYGD DSIKKAQNVINCFPKQWFMNLKGERTISQLENFCRYLVHLADTIYRNSIG CSDVEKRNARENIKHIVKLLASVRALDHAMTVASDH-------------- --N------------VKEFKSLIEGK-- >ENSPPYP00000012688 -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ---MF--------------------------------------------- ----------------------------------------RKARRVNVRK RNDSEEEE-------RER-------------------------------- -----------------------------------DEExx---------- ------------------------------xx------------------ -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- --------------x----------------------------------- -------------------------------------------------- -xx----------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- --------xx---------------------------------------- -------------------------------------------------- ----------------------------------------x--------- ----------xx-------------------------------------- -------------------------------------------------- ----------------xxxx-----xx----------------------- ---------------------------------------------xxx-- ------xxx----------------------------------------- -------------------------------------------------- -------------------------------------------------- -----x-------------------------------------------- ---------------xxExx------------------------------ ----------------------------------------------xxxx x-------------xPx--------------------------------- ---------------------------------xx-------------xx xxx----------------------------------------------- -------------------------------------------------- -------------------------------------------------- -----------------------------------------------xxx xxxxxxxxxx-xxxxxxRKRPRENKE--VP-------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ----------RAS-----------------------------------LL SF--DE-EE-EN-------------------------------------- -----------------------------------------------E-- ------EVFKVKKSSYSKKIVKLLKKEYKE-------------------- --------------------------------DLEKSK------------ -------------------------------------------------- -------------------------------------------------- -IKTELN-----------S------------------------------- ---------SAESEQPLDKTGHVKDTNQEDGVIISEHGEDEMDMES---- EKEEE--------------------------------------------- ---------KPKT-GGAFS------------------------------- ---------------------------NALSSLNVLRP-----------G EIPDAAFIHAARKKRQMARELGDFTP-HDNE-PGKGRLVR-ED--ENDA- SD-DEDDDEKRRIVFSVKEKSQRQKIAEE--I---GIEGSDDDALV-TGE QDEELSRWEQEQIRKGINIPQVQASQPAEV-NMYYQNTYQTMPYGSSYGI PYSY--TAY-----------------------------GSS-DAKSQKTD NTVPFKTPSNEMTPVTIDLVKKQLKD-R---------------------- ------------------------------------------LDSMKELH KTNRQQHEKHLQSRVDSTRAIERLEGSSGGIGERYKFLQEMRGYVQDLLE CFSEKVPLINELESAIHQLYKQRASRLVQRRQDDIKDESSEFSSHS---- ---------------NKALMAPNLDSFGRDRALYQEHAK-RRIAERE--- ---ARR-TRR-RQAREQTGKMADHLEGLSSDDEETSTDITNFNLEK--DR ISKESSKVFEDVLESFYSIDCIKSQFEAWRSKYYTSYKDAYIGLCLPKLF NPLIRLQLLTWTPLE----------------------------------- -AKCRDFENMLWFESLLFYGCEERE--QEKDDVDVALLPTIVEKVILPKL TVIAENMWDPFSTT--------------QTSRMVGITLKLINGYPSVVNA ENKN-----TQVYLKALLLRMRRTLDDDVFMPLYPKNVLENKNSGPYLFF QRQFWSSVKLLGNFLQWYGIFSNKTLQELSIDGLLNRYILMAFQNSEYGD DSIKKAQNVINCFPKQWFMNLKGERTISQLENFCRYLVHLADTIYRNSIG CSDVEKRNARENIKQIVKLLASVRALDHAMSVASDHxxxxxxxxxxxxxx xx-------------------------- >ENSCGRP00015017637 -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ---MIxxVTxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxSKARRVNVRK RNDSEEEE-------RER-------------------------------- -----------------------------------DEExx---------- ------------------------------xx------------------ -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- --------------x----------------------------------- -------------------------------------------------- -xx----------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- --------xx---------------------------------------- -------------------------------------------------- ----------------------------------------xxxxxxxxxx xxxxxxxxxxx--------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -----------------------------------------------xxx xxxx--x-----xxxxx--------------------------------- ---------------------------------xxx-----------xxx xxx----------------------------------------------- -------------------------------------------------- -------------------------------------------------- -----------------------------------------------xxx xxxxxxxGxxxxxxxxxRKRPRENKE--VP-------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ----------RAS-----------------------------------LL SF-QDE-EE-EN-------------------------------------- -----------------------------------------------E-- ------EVFKVKKSSYSKKIVKLLKKEYKE-------------------- --------------------------------DLEKSK------------ -------------------------------------------------- -------------------------------------------------- -IKTELN-----------T------------------------------- ---------TADNDQPLDKACHVKDTNQEDGVVISEHGEDEMDMES---- EKEEE--------------------------------------------- ---------KPKA-AGAFS------------------------------- ---------------------------NALSSLNVLRP-----------G EIPDAAFIHAARKKRQMARELGDFTP-HDNE-PGKGRLVR-ED--ENDA- SD-DEDDDEKRRIVFSVKEKSQRQKIAEE--I---GIEGSDDDALV-TGE QDEELSRWEQEQIRKGINIPQVQASQPTEV-NMYYQNTYQTMPYGASYGI PYSY--TAY-----------------------------GSS-DAKPQKTD STVPFKTPSNEMAPVTIDLVKKQLKD-R---------------------- ------------------------------------------LDSMKELH KTNRQQHEKHLQSRVDSTRAIERLEGASGGIGERYKFLQEMRGYVQDLLE CFSEKVPLINDLESAMHQLYKQRASRLVQRRQDDIKDESSEFSSHS---- ---------------NKALMAPNLDSFGRDRALYQEHAK-RRIAERE--- ---ARR-TRR-RQAREQTGKMADHLEGLSSDDEETSTDITNFNLEK--DR IVKESSKVFEDVLESFYSIDCIKAQFEAWRSKYYTSYKDAYIGLCLPRLF APLIRLQLLTWTPLE----------------------------------- -AKCCDFEYMLWFESLLFYGCEERE--QEKDDADVALLPTIVEKVILPKL TVIAENMWDPFSTT--------------QTSRMVGITLKLINGYPSVVNA ENKN-----TQVYLKALLLRMRRTLDDDVFMPLYPKNVLENKNSGPYLFF QRQFWSSVKLLGNFLQWYGIFSNKTLQELSIDGLLNRYILMAFQNSEYGD DSIKKAQNVINCFPKQWFVNLKGERTISQLENFCRYLVHLADTIYRNSIG CSDVEKRNARENIKQIVKLLASVRALDHAVSVASDH-------------- --N------------VKELKSLIEGK-- >ENSCGRP00000022051 -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -----------N-------------------------------------- -----------------------------------------------E-- ------EVFKVKKSSYSKKIVKLLKKEYKE-------------------- --------------------------------DLEKSK------------ -------------------------------------------------- -------------------------------------------------- -IKTELN-----------T------------------------------- ---------TADNDQPLDKACHVKDTNQEDGVVISEHGEDEMDMES---- EKEEE--------------------------------------------- ---------KPKA-AGAFS------------------------------- ---------------------------NALSSLNVLRP-----------G EIPDAAFIHAARKKRQMARELGDFTP-HDNE-PGKGRLVR-ED--ENDA- SD-DEDDDEKRRIVFSVKEKSQRQKIAEE--I---GIEGSDDDALV-TGE QDEELSRWEQEQIRKGINIPQVQASQPTEV-NMYYQNTYQTMPYGASYGI PYSY--TAY-----------------------------GSS-DAKPQKTD STVPFKTPSNEMAPVTIDLVKKQLKD-R---------------------- ------------------------------------------LDSMKELH KTNRQQHEKHLQSRVDSTRAIERLEGASGGIGERYKFLQEMRGYVQDLLE CFSEKVPLINDLESAMHQLYKQRASRLVQRRQDDIKDESSEFSSHS---- ---------------NKALMAPNLDSFGRDRALYQEHAK-RRIAERE--- ---ARR-TRR-RQAREQTGKMADHLEGLSSDDEETSTDITNFNLEK--DR IVKESSKVFEDVLESFYSIDCIKAQFEAWRSKYYTSYKDAYIGLCLPRLF APLIRLQLLTWTPLE----------------------------------- -AKCCDFEYMLWFESLLFYGCEERE--QEKDDADVALLPTIVEKVILPKL TVIAENMWDPFSTT--------------QTSRMVGITLKLINGYPSVVNA ENKN-----TQVYLKALLLRMRRTLDDDVFMPLYPKNVLENKNSGPYLFF QRQFWSSVKLLGNFLQWYGIFSNKTLQELSIDGLLNRYILMAFQNSEYGD DSIKKAQNVINCFPKQWFVNLKGERTISQLENFCRYLVHLADTIYRNSIG CSDVEKRNARENIKQIVKLLASVRALDHAVSVASDH-------------- --N------------VKELKSLIEGK-- >ENSCGRP00001016444 -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ---MF--------------------------------------------- ----------------------------------------RKARRVNVRK RNDSEEEE-------RER-------------------------------- -----------------------------------DEExx---------- ------------------------------xx------------------ -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- --------------x----------------------------------- -------------------------------------------------- -xx----------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- --------xx---------------------------------------- -------------------------------------------------- ----------------------------------------x--------- ----------xx-------------------------------------- -------------------------------------------------- ----------------xxxx-----xx----------------------- ---------------------------------------------xxx-- ------xxx----------------------------------------- -------------------------------------------------- -------------------------------------------------- -----x-------------------------------------------- ---------------xxExx------------------------------ ----------------------------------------------xxxx xxxx--x-----xxxxx--------------------------------- ---------------------------------xxx-----------xxx xxx----------------------------------------------- -------------------------------------------------- -------------------------------------------------- -----------------------------------------------xxx xxxxxxxGxxxxxxxxxRKRPRENKE--VP-------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ----------RAS-----------------------------------LL SF-QDE-EE-EN-------------------------------------- -----------------------------------------------E-- ------EVFKVKKSSYSKKIVKLLKKEYKE-------------------- --------------------------------DLEKSK------------ -------------------------------------------------- -------------------------------------------------- -IKTELN-----------T------------------------------- ---------TADNDQPLDKACHVKDTNQEDGVVISEHGEDEMDMES---- EKEEE--------------------------------------------- ---------KPKA-AGAFS------------------------------- ---------------------------NALSSLNVLRP-----------G EIPDAAFIHAARKKRQMARELGDFTP-HDNE-PGKGRLVR-ED--ENDA- SD-DEDDDEKRRIVFSVKEKSQRQKIAEE--I---GIEGSDDDALV-TGE QDEELSRWEQEQIRKGINIPQVQASQPTEV-NMYYQNTYQTMPYGASYGI PYSY--TAY-----------------------------GSS-DAKPQKTD STVPFKTPSNEMAPVTIDLVKKQLKD-R---------------------- ------------------------------------------LDSMKELH KTNRQQHEKHLQSRVDSTRAIERLEGASGGIGERYKFLQEMRGYVQDLLE CFSEKVPLINDLESAMHQLYKQRASRLVQRRQDDIKDESSEFSSHS---- ---------------NKALMAPNLDSFGRDRALYQEHAK-RRIAERE--- ---ARR-TRR-RQAREQTGKMADHLEGLSSDDEETSTDITNFNLEK--DR IVKESSKVFEDVLESFYSIDCIKAQFEAWRSKYYTSYKDAYIGLCLPRLF APLIRLQLLTWTPLE----------------------------------- -AKCCDFEYMLWFESLLFYGCEERE--QEKDDADVALLPTIVEKVILPKL TVIAENMWDPFSTT--------------QTSRMVGITLKLINGYPSVVNA ENKN-----TQVYLKALLLRMRRTLDDDVFMPLYPKNVLENKNSGPYLFF QRQFWSSVKLLGNFLQWYGIFSNKTLQELSIDGLLNRYILMAFQNSEYGD DSIKKAQNVINCFPKQWFVNLKGERTISQLENFCRYLVHLADTIYRNSIG CSDVEKRNARENIKQIVKLLASVRALDHAVSVASDH-------------- --N------------VKELKSLIEGK-- >ENSMAUP00000017444 -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -----------x-------------------------------------- -----------------------------------------------xxx xxxxxxQFFKVKKSSYSKKIVKLLKKEYKE-------------------- --------------------------------DLEKSK------------ -------------------------------------------------- -------------------------------------------------- -IKTELN-----------T------------------------------- ---------TADNEQPLDKACHVKDSNQEDGVVISEHGEDEMDMES---- EKEEE--------------------------------------------- ---------KPKA-GGAFS------------------------------- ---------------------------NALSSLNVLRP-----------G EIPDAAFIHAARKKRQMARELGDFTP-HDNE-PGKGRLVR-ED--ENDA- SD-DEDDDEKRRIVFSVKEKSQRQKIAEE--I---GIEGSDDDALV-TGE QDEELSRWEQEQIRKGINIPQVQASQPAEV-NVYYQSTYQTMPYGASYGV PYSY--TAY-----------------------------GSS-DAKSQKPD NTVPFKTPSNEMAPVTIDLVKKQLKD-R---------------------- ------------------------------------------LDSMKELH KTNRQQHEKHLQSRVDSTRAIERLEGSSGGIGERYKFLQEMRGYVQDLLE CFSEKVPLINDLESAIHQLYKQRASRLVQRRQDDIKDESSEFSSHS---- ---------------NKALMAPNLDSFGRDRALYQEHAK-RRIAERE--- ---ARR-TRR-RQAREQTGKMADHLEGLSSDDEETSTDITNFNLEK--DR ILKESSKVFEDVLESFYSIDCIKAQFEAWRSKYYTSYKDAYIGLCLPKLF NPLVRLQLLTWTPLE----------------------------------- -AKCPDFEYMLWFESLLFYGCEERE--QEKDDVDVALLPTIVEKVILPKL TVIAEHMWDPFSTT--------------QTSRMVGITLKLINGYPSVVNA ENKN-----TQVYLKALLLRMRRTLDDDVFMPLYPKNVLENKNSGPYLFF QRQFWSSVKLLGNFLQWYGIFSNKTLQELSIDGLLNRYILMAFQNSEYGD DSIKKAQNVINCFPKQWFVNLKGERTISQLENFCRYLVHLADTIYRNSIG CSDVEKRNARENIKQIVKLLASVRALDHAVSVASDH-------------- --N------------VKELKSLIEGK-- >ENSMUSP00000113835 -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ---MF--------------------------------------------- ----------------------------------------RKARRVNVRK RNDSEEEE-------RER-------------------------------- -----------------------------------DEExx---------- ------------------------------xx------------------ -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- --------------x----------------------------------- -------------------------------------------------- -xx----------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- --------xx---------------------------------------- -------------------------------------------------- ----------------------------------------x--------- ----------xx-------------------------------------- -------------------------------------------------- ----------------xxxx-----xx----------------------- ---------------------------------------------xxx-- ------xxx----------------------------------------- -------------------------------------------------- -------------------------------------------------- -----x-------------------------------------------- ---------------xxExx------------------------------ ----------------------------------------------xxxx xx-----------xxxx--------------------------------- ---------------------------------xx-------------xx xxx----------------------------------------------- -------------------------------------------------- -------------------------------------------------- -----------------------------------------------xxx xxxxxxxGxxxxxxxxxRKRPRENKE--VP-------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ----------RAS-----------------------------------LL SF-QDE-EE-EN-------------------------------------- -----------------------------------------------E-- ------EVFKVKKSSYSKKIVKLLKKEYKE-------------------- --------------------------------DLEKSK------------ -------------------------------------------------- -------------------------------------------------- -IKTELN-----------T------------------------------- ---------AADSDQPLDKTCHAKDTNPEDGVVISEHGEDEMDMES---- EKEEE--------------------------------------------- ---------KPKA-GGAFS------------------------------- ---------------------------NALSSLNVLRP-----------G EIPDAAFIHAARKKRQLARELGDFTP-HDSE-PGKGRLVR-ED--ENDA- SD-DEDDDEKRRIVFSVKEKSQRQKIAEE--I---GIEGSDDDALV-TGE QDEELSRWEQEQIRKGINIPQVQASQPSEV-NVYYQNTYQTMPYGASYGI PYSY--TAY-----------------------------GSS-DAKSQKTD NTVPFKTPSNEMAPVTIDLVKRQLKD-R---------------------- ------------------------------------------LDSMKELH KTNQQQHEKHLQSRVDSTRAIERLEGSSGGIGERYKFLQEMRGYVQDLLE CFSEKVPLINELESAIHQLYKQRASRLVQRRQDDIKDESSEFSSHS---- ---------------NKALMAPNLDSFGRDRALYQEHAK-RRIAERE--- ---ARR-TRR-RQAREQTGQMADHLEGLSSDDEETSTDITNFNLEK--DR ILKESSKVFEDVLESFYSIDCIKAQFEAWRSKYYMSYKDAYIGLCLPKLF NPLIRLQLLTWTPLE----------------------------------- -AKCRDFETMLWFESLLFYGCEDRE--QEKDEADVALLPTIVEKVILPKL TVIAETMWDPFSTT--------------QTSRMVGITMKLINGYPSVVNA DNKN-----TQVYLKALLLRMRRTLDDDVFMPLYPKNVLENKNSGPYLFF QRQFWSSVKLLGNFLQWYGIFSNKTLQELSIDGLLNRYILMAFQNSEYGD DSIRKAQNVINCFPKQWFVNLKGERTISQLENFCRYLVHLADTIYRNSIG CSDVEKRNARENIKQIVKLLASVRALDHAISVASDH-------------- --N------------VKEVKSLIEGK-- >MGP_SPRETEiJ_P0044147 -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ---MF--------------------------------------------- ----------------------------------------RKARRVNVRK RNDSEEEE-------RER-------------------------------- -----------------------------------DEExx---------- ------------------------------xx------------------ -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- --------------x----------------------------------- -------------------------------------------------- -xx----------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- --------xx---------------------------------------- -------------------------------------------------- ----------------------------------------x--------- ----------xx-------------------------------------- -------------------------------------------------- ----------------xxxx-----xx----------------------- ---------------------------------------------xxx-- ------xxx----------------------------------------- -------------------------------------------------- -------------------------------------------------- -----x-------------------------------------------- ---------------xxExx------------------------------ ----------------------------------------------xxxx xx-----------xxxx--------------------------------- ---------------------------------xx-------------xx xxx----------------------------------------------- -------------------------------------------------- -------------------------------------------------- -----------------------------------------------xxx xxxxxxxGxxxxxxxxxRKRPRENKE--VP-------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ----------RAS-----------------------------------LL SF-QDE-EE-EN-------------------------------------- -----------------------------------------------E-- ------EVFKVKKSSYSKKIVKLLKKEYKE-------------------- --------------------------------DLEKSK------------ -------------------------------------------------- -------------------------------------------------- -IKTELN-----------T------------------------------- ---------AADSDQPLDKTCHAKDTNPEDGVVISEHGEDEMDMES---- EKEEE--------------------------------------------- ---------KPKA-GGTFS------------------------------- ---------------------------NALSSLNVLRP-----------G EIPDAAFIHAARKKRQLARELGDFTP-HDSE-PGKGRLVR-ED--ENDA- SD-DEDDDEKRRIVFSVKEKSQRQKIAEE--I---GIEGSDDDALV-TGE QDEELSRWEQEQIRKGINIPQVQASQPSEV-NVYYQNTYQTMPYGASYGI PYSY--TAY-----------------------------GSS-DAKSQKTD NTVPFKTPSNEMAPVTIDLVKRQLKD-R---------------------- ------------------------------------------LDSMKELH KTNQQQHEKHLQSRVDSTRAIERLEGSSGGIGERYKFLQEMRGYVQDLLE CFSEKVPLINELESAIHQLYKQRASRLVQRRQDDIKDESSEFSSHS---- ---------------NKALMAPNLDSFGRDRALYQEHAK-RRIAERE--- ---ARR-TRR-RQAREQTGQMADHLEGLSSDDEETSTDITNFNLEK--DR ILKESSKVFEDVLESFYSIDCIKAQFEAWRSKYYMSYKDAYIGLCLPKLF NPLIRLQLLTWTPLE----------------------------------- -AKCRDFETMLWFESLLFYGCEERE--QEKDEADVALLPTIVEKVILPKL TVIAETMWDPFSTT--------------QTSRMVGITMKLINGYPSVVNA DNKN-----TQVYLKALLLRMRRTLDDDVFMPLYPKNVLENKNSGPYLFF QRQFWSSVKLLGNFLQWYGIFSNKTLQELSIDGLLNRYILMAFQNSEYGD DSIRKAQNVINCFPKQWFVNLKGERTISQLENFCRYLVHLADTIYRNSIG CSDVEKRNARENIKQIVKLLASVRALDHAISVASDH-------------- --N------------VKEVKSLIEGK-- >ENSMSIP00000018972 -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ---MF--------------------------------------------- ----------------------------------------RKARRVNVRK RNDSEEEE-------RER-------------------------------- -----------------------------------DEExx---------- ------------------------------xx------------------ -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- --------------x----------------------------------- -------------------------------------------------- -xx----------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- --------xx---------------------------------------- -------------------------------------------------- ----------------------------------------x--------- ----------xx-------------------------------------- -------------------------------------------------- ----------------xxxx-----xx----------------------- ---------------------------------------------xxx-- ------xxx----------------------------------------- -------------------------------------------------- -------------------------------------------------- -----x-------------------------------------------- ---------------xxExx------------------------------ ----------------------------------------------xxxx xx-----------xxxx--------------------------------- ---------------------------------xx-------------xx xxx----------------------------------------------- -------------------------------------------------- -------------------------------------------------- -----------------------------------------------xxx xxxxxxxGxxxxxxxxxRKRPRENKE--VP-------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ----------RAS-----------------------------------LL SF-QDE-EE-EN-------------------------------------- -----------------------------------------------E-- ------EVFKVKKSSYSKKIVKLLKKEYKE-------------------- --------------------------------DLEKSK------------ -------------------------------------------------- -------------------------------------------------- -IKTELN-----------T------------------------------- ---------AADSDQPLDKTCHAKDTNPEDGVVISEHGEDEMDMES---- EKEEE--------------------------------------------- ---------KPKA-GGAFS------------------------------- ---------------------------NALSSLNVLRP-----------G EIPDAAFIHAARKKRQLARELGDFTP-HDSE-PGKGRLVR-ED--ENDA- SD-DEDDDEKRRIVFSVKEKSQRQKIAEE--I---GIEGSDDDALV-TGE QDEELSRWEQEQIRKGINIPQVQASQPSEV-NVYYQSTYQTMPYGASYGI PYSY--TAY-----------------------------GSS-DAKSQKTD NTVPFKTPSNEMAPVTIDLVKRQLKD-R---------------------- ------------------------------------------LDSMKELH KTNQQQHEKHLQSRVDSTRAIERLEGSSGGIGERYKFLQEMRGYVQDLLE CFSEKVPLINELESAIHQLYKQRASRLVQRRQDDIKDESSEFSSHS---- ---------------NKALMAPNLDSFGRDRALYQEHAK-RRIAERE--- ---ARR-TRR-RQAREQTGQMADHLEGLSSDDEETSTDITNFNLEK--DR ILKESSKVFEDVLESFYSIDCIKAQFEAWRSKYYMSYKDAYIGLCLPKLF NPLIRLQLLTWTPLE----------------------------------- -AKCRDFETMLWFESLLFYGCEERE--QEKDEADVALLPTIVEKVILPKL TVIAETMWDPFSTT--------------QTSRMVGITMKLINGYPSVVNA DNKN-----TQVYLKALLLRMRRTLDDDVFMPLYPKNVLENKNSGPYLFF QRQFWSSVKLLGNFLQWYGIFSNKTLQELSIDGLLNRYILMAFQNSEYGD DSIRKAQNVINCFPKQWFVNLKGERTISQLENFCRYLVHLADTIYRNSIG CSDVEKRNARENIKQIVKLLASVRALDHAISVASDH-------------- --N------------VKEVKSLIEGK-- >MGP_CAROLIEiJ_P0042248 -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ---MF--------------------------------------------- ----------------------------------------RKARRVNVRK RNDSEEEE-------RER-------------------------------- -----------------------------------DEExx---------- ------------------------------xx------------------ -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- --------------x----------------------------------- -------------------------------------------------- -xx----------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- --------xx---------------------------------------- -------------------------------------------------- ----------------------------------------x--------- ----------xx-------------------------------------- -------------------------------------------------- ----------------xxxx-----xx----------------------- ---------------------------------------------xxx-- ------xxx----------------------------------------- -------------------------------------------------- -------------------------------------------------- -----x-------------------------------------------- ---------------xxExx------------------------------ ----------------------------------------------xxxx xx-----------xxxx--------------------------------- ---------------------------------xx-------------xx xxx----------------------------------------------- -------------------------------------------------- -------------------------------------------------- -----------------------------------------------xxx xxxxxxxGxxxxxxxxxRKRPRENKE--VP-------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ----------RAS-----------------------------------LL SF-QDE-EE-EN-------------------------------------- -----------------------------------------------E-- ------EVFKVKKSSYSKKIVKLLKKEYKE-------------------- --------------------------------DLEKSK------------ -------------------------------------------------- -------------------------------------------------- -IKTELN-----------T------------------------------- ---------AADSDQPLDKTCHAKDANPEDGVVISEHGEDEMDMES---- EKEEE--------------------------------------------- ---------KPKA-GGAFS------------------------------- ---------------------------NALSSLNVLRP-----------G EIPDAAFIHAARKKRQLARELGDFTP-HDSE-PGKGRLVR-ED--ENDA- SD-DEDDDEKRRIVFSVKEKSQRQKIAEE--I---GIEGSDDDALV-TGE QDEELSRWEQEQIRKGINIPQVQASQPTEV-NMYYQNTYQTMPYGASYGI PYSY--TAY-----------------------------GSS-DAKSQKTD NTVPFKTPSNEMAPVTIDLVKKQLKD-R---------------------- ------------------------------------------LDSMKELH KTNQQQHEKHLQSRVDSTRAIERLEGSSGGIGERYKFLQEMRGYVQDLLE CFSEKVPLINELESAIHQLYRQRASRLVQRRQDDIKDESSEFSSHS---- ---------------NKALMAPNLDSFGRDRALYQEHAK-RRIAERE--- ---ARR-TRR-RQAREQTGQMADHLEGLSSDDEETSTDITNFNLEK--DR ILKESSKVFEDVLESFYSIDCIKAQFEGWRSKYYMSYKDAYIGLCLPKLF NPLIRLQLLTWTPLE----------------------------------- -AKCRDFETMLWFESLLFYGCEERE--QEKDDADVALLPTIVEKVILPKL TVIAETMWDPFSTT--------------QTSRMVGITMKLINGYPSVVNA DNKN-----TQVYLKALLLRMRRTLDDDVFMPLYPKNVLENKNSGPYLFF QRQFWSSVKLLGNFLQWYGIFSNKTLQELSIDGLLNRYILMAFQNSEYGD DSIRKAQNVINCFPKQWFVNLKGERTISQLENFCRYLVHLADTIYRNSIG CSDVEKRNARENIKQIVKLLASVRALDHAVSVASDH-------------- --N------------VKEVKSLIEGK-- >MGP_PahariEiJ_P0029609 -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ---MF--------------------------------------------- ----------------------------------------RKARRVNVRK RNDSEEEE-------RER-------------------------------- -----------------------------------DEExx---------- ------------------------------xx------------------ -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- --------------x----------------------------------- -------------------------------------------------- -xx----------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- --------xx---------------------------------------- -------------------------------------------------- ----------------------------------------x--------- ----------xx-------------------------------------- -------------------------------------------------- ----------------xxxx-----xx----------------------- ---------------------------------------------xxx-- ------xxx----------------------------------------- -------------------------------------------------- -------------------------------------------------- -----x-------------------------------------------- ---------------xxExx------------------------------ ----------------------------------------------xxxx xx-----------xxxx--------------------------------- ---------------------------------xx-------------xx xxx----------------------------------------------- -------------------------------------------------- -------------------------------------------------- -----------------------------------------------xxx xxxxxxxGxxxxxxxxxRKRPRENKE--VP-------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ----------RAS-----------------------------------LL SF-QDE-EE-EN-------------------------------------- -----------------------------------------------E-- ------EVFKVKKSSYSKKIVKLLKKEYKE-------------------- --------------------------------DLEKSK------------ -------------------------------------------------- -------------------------------------------------- -IKTELS-----------T------------------------------- ---------AADSDQPLDKTCHAKDTNPEDGVVVSEHGEDEMDMES---- EKEEE--------------------------------------------- ---------KPKA-GGAFS------------------------------- ---------------------------NALSSLNVLRP-----------G EIPDAAFIHAARKKRQLARELGDFTP-HDSE-PGKGRLVR-ED--ENDA- SD-DEDDDEKRRIVFSVKEKSQRQKIAEE--I---GIEGSDDDALV-TGE QDEELSRWEQEQIRKGINIPQVQASQPTEV-NMYYQNTYQTMPYGASYGI PYSY--TAY-----------------------------GSS-DAKSQKTD NTVPFKTPSNEMAPVTIDLVKKQLKD-R---------------------- ------------------------------------------LDSMKELH KTNRQQHEKHLQSRVDSTRAIERLEGSSGGIGERYKFLQEMRGYVQDLLE CFSEKVPLINELESAIHQLYKQRASRLVQRRQDDIKDESSEFSSHS---- ---------------NKALMAPNLDSFGRDRALYQEHAK-RRIAERE--- ---ARR-TRR-RQAREQTGQMADHLEGLSSDDEETSTDITNFNLEK--DR ILKESSKVFEDVLESFYSIDCIKAQFEAWRSKYYMSYKDAYIGLCLPKLF NPLIRLQLLTWTPLE----------------------------------- -AKCRDFETMLWFESLLFYGCEERE--QEKDDVDVALLPTIVEKVILPKL TVIAETMWDPFSTT--------------QTSRMVGITMKLINGYPSVVNA ENKN-----TQVYLKALLLRMRRTLDDDVFMPLYPKNVLENKNSGPYLFF QRQFWSSVKLLGNFLQWYGIFSNKTLQELSIDGLLNRYILMAFQNSEYGD DSIRKAQNVINCFPKQWFVNLKGERTISQLENFCRYLVHLADTIYRNSIG CSDVEKRNARENIKQIVKLLASVRALDHALSVASDH-------------- --N------------VKEVKSLMDGK-- >ENSRNOP00000002800 -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ---MF--------------------------------------------- ----------------------------------------RKARRVNVRK RNDSEEEE-------RER-------------------------------- -----------------------------------DEExx---------- ------------------------------xx------------------ -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- --------------x----------------------------------- -------------------------------------------------- -xx----------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- --------xx---------------------------------------- -------------------------------------------------- ----------------------------------------x--------- ----------xx-------------------------------------- -------------------------------------------------- ----------------xxxx-----xx----------------------- ---------------------------------------------xxx-- ------xxx----------------------------------------- -------------------------------------------------- -------------------------------------------------- -----x-------------------------------------------- ---------------xxExx------------------------------ ----------------------------------------------xxxx x------------xxxx--------------------------------- ---------------------------------xx-------------xx xxx----------------------------------------------- -------------------------------------------------- -------------------------------------------------- -----------------------------------------------xxx xxxxxxxGxxxxxxxxxRKRPRENKE--VP-------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ----------RAS-----------------------------------LL SF-QDE-EE-EN-------------------------------------- -----------------------------------------------E-- ------EVFKVKKSSYSKKIVKLLKKEYKE-------------------- --------------------------------DLEKSK------------ -------------------------------------------------- -------------------------------------------------- -IKTELS-----------A------------------------------- ---------AADSDQPLDKMCHAKDTNPEDGVVISEHGEDEMDMES---- EKEEE--------------------------------------------- ---------KPKA-GGAFS------------------------------- ---------------------------NALSSLNVLRP-----------G EIPDAAFIHAARKKRQLARELGDFTP-HDSE-PGKGRLVR-ED--ENDA- SD-DEDDDEKRRIVFSVKEKSQRQKIAEE--I---GIEGSDDDALV-TGE QDEELSRWEQEQIRKGINIPQVQASQPTEV-NMYYQNTYQTMPYGASYGV PYSY--TAY-----------------------------GSS-DAKSQKSD NTVPFKTPSNEAAPITIDLVKKQLKD-R---------------------- ------------------------------------------LDSMKELH KTNRQQHEKHLQSRVDSTRAIERLEGSSGGIGERYKFLQEMRGYVQDLLE CFSEKVPLINELESAIHQLYKQRASRLVQRRQDDIKDESSEFSSHS---- ---------------NKALMAPNLDSFGRDRALYQEHAK-RRIAERE--- ---ARR-TRR-RQAREQTGQMADHLEGLSSDDEETSTDITNFNLER--DR ILKESSKVFEDVLESFCSIDCIKAQFEAWRSKYYMSYKDAYIGLCLPKLF NPLIRLQLLTWTPLE----------------------------------- -AKCRDFENMLWFESLLFYGCEERE--QEKDDVDVALLPTIVEKVILPKL TVIAENMWDPFSTT--------------QTSRMVGITLKLINGYPSVVNA ENKN-----TQVYLKALLLRMRRTLDDDVFMPLYPKNVLENKNSGPYLFF QRQFWSSVKLLGNFLQWYGIFSNKTLQELSIDGLLNRYILMAFQNSEYGD DSIRKAQNVINCFPKQWFVNLKGERTISQLENFCRYLVHLADTIYRNSIG CSDVEKRNARENIKQIVKLLASVRALDHAVSVASDH-------------- --N------------VKEVKSLIEGK-- >ENSPEMP00000026056 -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ---MF--------------------------------------------- ----------------------------------------RKARRVNVRK RNDSEEEE-------RER-------------------------------- -----------------------------------DEExx---------- ------------------------------xx------------------ -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- --------------x----------------------------------- -------------------------------------------------- -xx----------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- --------xx---------------------------------------- -------------------------------------------------- ----------------------------------------x--------- ----------xx-------------------------------------- -------------------------------------------------- ----------------xxxx-----xx----------------------- ---------------------------------------------xxx-- ------xxx----------------------------------------- -------------------------------------------------- -------------------------------------------------- -----xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx xxxxxxxxxxxxxxx----------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -----------N-------------------------------------- -----------------------------------------------E-- ------EVFKVKKSSYSKKIVKLLKKEYKE-------------------- --------------------------------DLEKSK------------ -------------------------------------------------- -------------------------------------------------- -IKTELS-----------T------------------------------- ---------AADNDQPLDKACHVKDANPEDGVIISEHGEDEMDMES---- EKEEE--------------------------------------------- ---------KPKA-GGTFS------------------------------- ---------------------------NALSSLNVLRP-----------G EIPDAAFIHAARKKRQMARELGDFTP-HDNE-PGKGRLVR-ED--ENDA- SD-DEDDDEKRRIVFSVKEKSQRQKIAEE--I---GIEGSDDDALV-TGE QDEELSRWEQEQIRKGINIPQVQASQPTEV-NMYYQNTYQTMPYGASYGI PYSY--TAY-----------------------------GSS-DAKSQKTD NTVPFKTPSNEMAPVTIDLVKKQLKD-R---------------------- ------------------------------------------LDSMKELH KANRQQHERHLQSRVDSTRAIERLEGSSGGIGERYKFLQEMRGYVQDLLE CFSEKVPLINELESAIHQLYKQRASRLVQRRQDDIKDESSEFSSHS---- ---------------NKALMAPNLDSFGRDRALYQEHAK-RRIAERE--- ---ARR-TRR-RQAREQTGKMADHLEGLSSDDEETSTDITNFNLEK--DR ILKESSKVFEDVLESFYSIDCIKAQFEAWRSKYYTSYKDAYIGLCLPKLF NPLIRLQLLTWTPLE----------------------------------- -AKCPDFEYMLWFESLLFYGCEERE--QEKDDVDVALLPTIVEKVILPKL TVIAENMWDPFSTT--------------QTSRMVGITLKLINGYPSVVNA ENKN-----TQVYLKALLLRMRRTLDDDVFMPLYPKNVLENKNSGPYLFF QRQFWSSVKLLGNFLQWYGIFSNKTLQELSIDGLLNRYILMAFQNSECGD DSIKKAQNVINCFPKQWFVNLKGERTISQLENFCRYLVHLADTIYRNSIG CSDVEKRNARENIKQIVKLLASVRALDHAVSVASDH-------------- --N------------VKELKSLVEGK-- >ENSMUGP00000014801 -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ---MF--------------------------------------------- ----------------------------------------RKARRVNVRK RNDSEEEE-------RER-------------------------------- -----------------------------------DEExx---------- ------------------------------xx------------------ -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- --------------x----------------------------------- -------------------------------------------------- -xx----------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- --------xx---------------------------------------- -------------------------------------------------- ----------------------------------------x--------- ----------xx-------------------------------------- -------------------------------------------------- ----------------xxxx-----xx----------------------- ---------------------------------------------xxx-- ------xxx----------------------------------------- -------------------------------------------------- -------------------------------------------------- -----x-------------------------------------------- ---------------xxExx------------------------------ ----------------------------------------------xxxx -------------xxxx--------------------------------- ---------------------------------xx-------------xx xxx----------------------------------------------- -------------------------------------------------- -------------------------------------------------- -----------------------------------------------xxx xxxxxxxGxxxxxxxxxRKRPRENKE--VP-------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ----------RAS-----------------------------------LL SF-QDE-EE-EN-------------------------------------- -----------------------------------------------E-- ------EVFKVKKSSYSKKIVKLLKKEYKE-------------------- --------------------------------DLEKSR------------ -------------------------------------------------- -------------------------------------------------- -IKTELN-----------T------------------------------- ---------AADNEQPLDKPCHVKDTNEEDGVIISEHAEDEMDMER---- EREEE--------------------------------------------- ---------RPKA-GGAFS------------------------------- ---------------------------NALSSLNVLRP-----------G EIPDAAFIHAARKKRQMARELGDFTP-HDSE-PGKGRLVR-ED--ENDA- SD-DEDDDEKRRIVFSVKEKSQRQKIAEE--I---GIEGSDDDALV-TAE QDEELSRWEQEQIRKGINIPQVQSSQPTEV-NMYYQNTYQTMPYGASYGI PYSY--TAY-----------------------------GSS-DAKPQKTD NTVPFKTPSNEMAPVTIDLVKKQLKD-R---------------------- ------------------------------------------LDSMKELH KTNRQQHEKHLQSRVDSTRAIERLEGSSGGIGERYKFLQEMRGYVQDLLE CFSEKVPLINELESAIHQLYKQRASRLVQRRQDDIKDESSEFSSHS---- ---------------NKALMAPNLDSFGRDRALYQEHAK-RRIAERE--- ---ARR-TRR-RQAREQTGQMADHLEGLSSDDEETSTDITNFNLEK--DR ILKESSKVFEDVLESFYSIDCIKAQFEAWRSKYYTSYKDAYIGLCLPKLF NPLIRLQLLTWTPLE----------------------------------- -AKCRDFENMLWFESLLFYGCEEQE--QEKDDADIALLPTIVEKAILPKL TVIAENMWDPFSTT--------------QTSRMVGITLKLINGYPSVVNA ENKN-----TQVYLKALLLRMRRTLDDDVFMPLYPKNVLENKNSGPYLFF QRQFWSSVKLLGNFLQWYGIFSNKTLQELSIDGLLNRYILMAFQNSEYGD DSIRKAQNVINCFPKQWFVNLKGERTISQLENFCRYLVHLADTIYRNSIG CSDVEKRNARENIKQIVKLLASVRALDHAVSVASDH-------------- --N------------VKELKSLIEGK-- >ENSNGAP00000021475 -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ---MF--------------------------------------------- ----------------------------------------RKARRVNVRK RNDSEEEE-------RER-------------------------------- -----------------------------------DDExx---------- ------------------------------xx------------------ -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- --------------x----------------------------------- -------------------------------------------------- -xx----------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- --------xx---------------------------------------- -------------------------------------------------- ----------------------------------------x--------- ----------xx-------------------------------------- -------------------------------------------------- ----------------xxxx-----xx----------------------- ---------------------------------------------xxx-- ------xxx----------------------------------------- -------------------------------------------------- -------------------------------------------------- -----x-------------------------------------------- ---------------xxExx------------------------------ ----------------------------------------------xxxx --------------xPx--------------------------------- ---------------------------------xx-------------xx xxx----------------------------------------------- -------------------------------------------------- -------------------------------------------------- -----------------------------------------------xxx xxxxxxxGxxxxxxxxxRKRPRENKE--VA-------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ----------RAS-----------------------------------LL SF-QDE-EE-EN-------------------------------------- -----------------------------------------------E-- ------EVFKVKKSSYSKKIVKLLKKEYKE-------------------- --------------------------------DLEKSK------------ -------------------------------------------------- -------------------------------------------------- -IKTELN-----------S------------------------------- ---------AADNDQPLDKTGHVKDTGQEDGVLISEHGEDEMDMES---- EKEED--------------------------------------------- ---------KPKA-GGTFS------------------------------- ---------------------------NALSSLNVLRP-----------G EIPDAAFIHAARKKRQMARELGDFPP-HDNE-PGKGRLVR-ED--ENDA- SD-DEDDDEKRRIVFSVKEKSQRQKIAEE--I---GIEGSDDDALV-TGE QDEELSRWEQEQIRKGINIPQVQASQPTEV-NVYYQNTYQTMPYGSSYGI PYSY--TAY-----------------------------GSS-DAKSQKTD NTVPFKTPSNEMTPVTIDLVKKQLKD-R---------------------- ------------------------------------------LDSMKELH KTNRQQHEKHLQSRVDSTRAIERLEGSSGGIGERYKFLQEMRGYVQDLLE CFSEKVPLINELESAIHQLYKQRASRLVQRRQDDIKDESSEFSSHS---- ---------------NKALMAPNLDSFGRDRALYQEHAK-RRIAERE--- ---ARR-TRR-RQAREQTGKMADHLEGLSSDDEETSTDTTNFNLEK--DR ISKESSKVFEDVLESFYSIDCIKSQFEAWRSKYYMSYKDAYIGLCLPKLF NPLIRLQLLTWTPLD----------------------------------- -AKCRDFENMLWFESLLFYGCEERE--QEKDDVDVALLPTIVEKVILPKL TVIAENMWDPFSTT--------------QTSRMVGITLKLINGYPSVVNA ENKN-----TQVYLKALLLRMRRTLDDDVFMPLYPRNVLENKNCGPYLFF QRQFWSSVKLLGNFLQWYGIFSNKTLQELSIDGLLNRYILMAFQNSEYGD DSIKKAQNVINCFPKQWFVNLKGERTISQLENFCRYLVHLADTIYRNSIG CSDVEKRNARENIKQIVRLLASVGALDHAVSVASDH-------------- --N------------VKEFKSLIEGK-- >ENSCPOP00000011193 -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ---MF--------------------------------------------- ----------------------------------------RKARRVNVRK RNDS---------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ---------------------------------------xxxxxxxxxxx xxxxxxxxxxxxxxxx---------------------------------- -------------------------------------------------- -------------------------------------------------- --------x----------------------------------------- -------------------------------------------------- -------------------------------------------------- -----x-------------------------------------------- ---------------xxExx------------------------------ ----------------------------------------------xxxx x-------------xPx--------------------------------- ---------------------------------xx-------------xx xxx----------------------------------------------- -------------------------------------------------- -------------------------------------------------- -----------------------------------------------xxx xxxxxxxGxxxxxxxxxRKRPRENKE--VP-------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ----------RAS-----------------------------------LL SF-QDE-EE-EN-------------------------------------- -----------------------------------------------E-- ------EVFKVKKSSYSKKIVKLLKKEYKE-------------------- --------------------------------DLEKSK------------ -------------------------------------------------- -------------------------------------------------- -IKNELN-----------S------------------------------- ---------SANNEQSLDKTGHVKDTNQEDGIIINEHGEDEMDMES---- EKEEE--------------------------------------------- ---------KPKA-GGAFS------------------------------- ---------------------------NALSSLNVLRP-----------G EIPDAAFIHAARKKRQMARELGDFTP-HDNE-PGKGRLVR-ED--ENDA- SD-DEDDDEKRRIVFSVKEKSQRQKIAEE--I---GIEGSDDDALV-TGE QDEELSRWEQEQIRKGINIPQVQASQPAEV-NMYYQNTYPTIPYGSSYGI PYSY--TAY-----------------------------GSS-DAKSQKTD NTVPFKTPSNEMTPVTIDLVKKQLKD-R---------------------- ------------------------------------------LDSMKELH KTNRQQHEKHLQSRVDSTRAIERLEGSSGGIGERYKFLQEMRGYVQDLLE CFSEKVPLINELESSIHQLYKQRASRLVQRRQDDIKDESSEFSSHS---- ---------------NKALMAPNLDSFGRDRALYQEHAK-RRIAERE--- ---ARR-TRR-RQAREQTGKMADHLEGLSSDDEETSTDITNFNLEK--DR ISKESSKVFEDVLESFYSIDCIKSQFEAWRSKYYMSYKDAYIGLCLPKLF NPLIRLQLLTWTPLE----------------------------------- -AKCRDFENMLWFESLLFYGCEERE--QEKDDVDVALLPTIVEKVILPKL TVIAENMWDPFSTT--------------QTSRMVGITLKLINGYPSVVNA ENKN-----TQVYLKALLLRMRRTLDDDVFMPLYPKNVLENKNSGPYLFF QRQFWSSVKLLGNFLQWYGIFSNKTLQELSIDGLLNRYILMAFQNSEYGD DSIKKAQNVINCFPKQWFMNLKGERTISQLENFCRYLVHLADTIYRNSIG CCDVEKRNARENIKQIVKLLASVRALDHAMSVASDH-------------- --N------------VKEFKSLIEGK-- >ENSUMAP00000027486 -------------------------------------------------- ---------------------------------------xx--------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ------------------------------xxxxx--------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- --------xx---------------------------------------- -------------------------------------------------- ----------------------------------------x--------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------xxxx--------------------------------- -------------------------------------------------- ----xxxxxxxx-------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------xxxxx-------- ---------------------RENKE--VP-------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ----------RAS-----------------------------------LL SF-QDE-EE-EN-------------------------------------- -----------------------------------------------E-- ------EVFKVKKSSYSKKIVKLLKKEYKE-------------------- --------------------------------DLEKSK------------ -------------------------------------------------- -------------------------------------------------- -IKTELN-----------S------------------------------- ---------SADNEPPLDKAGHVKDTSQEDGVIISEHGEDEMDMES---- EKEEE--------------------------------------------- ---------KPKA-GGAFS------------------------------- ---------------------------NALSSLNVLRP-----------G EIPDAAFIHAARKKRQMARELGDFTP-HDSE-PGKGRLVR-ED--ENDA- SD-DEDDDEKRRIVFSVKEKSQRQKIAEE--I---GIEGSDDDALV-TGE QDEELSRWEQEQIRKGINIPQVQASQPTEV-NMYYQNTYQTMPYGSSYGI PYSY--TAY-----------------------------GSS-DAKSQKTD NTVPFKTPSNEMTPVTIDLVKKQLKD-R---------------------- ------------------------------------------LDSMKELH KTNRQQHEKHLQSRVDSTRAIERLEGSSGGIGERYKFLQEMRGYVQDLLE CFSEKVPLINELESAIHQLYKQRASRLVQRRQDDIKDESSEFSSHS---- ---------------NKALMAPNLDSFGRDRALYQEHAK-RRIAERExxx xx-----------AREQTGKMADHLEGLSSDDEETSTDITNFNLEK--DR ISKESSKVFEDVLESFYSIDCIKSQFEAWRSKYYLSYKDAYIGLCLPKLF NPLIRLQLLTWTPLE----------------------------------- -AKCRDFENMLWFESLLFYGCEERE--QEKDDVDVALLPTIVEKVILPKL TVIAENMWDPFSTT--------------QTSRMVGITLKLINGYPSVVNA ENKN-----TQVYLKALLLRMRRTLDDDVFMPLYPKNVLENKNSGPYLFF QRQFWSSVKLLGNFLQWYGIFSNKTLQELSIDGLLNRYILMAFQNSEYGD DSIKKAQNVISCFPKQWFMNLKGERTISQLENFCRYLVHLADTIYRNSIG CSDVEKRNARENIKQIVKLLASVRALDHAMSVASDH-------------- --N------------VKEFKSLIEGK-- >ENSMLUP00000005173 -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ----------EN-------------------------------------- -----------------------------------------------E-- ------EVFKVKKSSYSKKIVKLLKKEYKE-------------------- --------------------------------DLEKSK------------ -------------------------------------------------- -------------------------------------------------- -IKTELN-----------S------------------------------- ---------SADNEPPLDKTGHVKDPSQEDGAAVGEHGEDEMDMES---- EKEEE--------------------------------------------- ---------KPKAxGGAFS------------------------------- ---------------------------NALSSLNVLRP-----------G EIPDAAFIHAARKKRQMARELGDFTP-HDSE-PGKGRLVR-ED--ENDA- SD-DEDDDEKRRIVFSVKEKSQRQKIAEE--I---GIEGSDDDALV-AGE QDEELSRWEQEQIRKGINIPQVQASQPAEV-NMYYPNTYPTMPYGSSYGI PYSY--TAY-----------------------------GSS-DGKSQKTD NSAPFKTPSNEMTPVTIDLVKKQLKD-R---------------------- ------------------------------------------LDSMKDVH KANRQQHEKHLQSRVDSTRAIERLEGSSGGIGERYKFLQEMRGYVQDLLE CFSEKVPLINELESSIHQLYKQRASRLVQRRQDDIKDESSEFSSHS---- ---------------NKALMAPNLDSFGRDRALYQEHAK-RRIAERE--- ---ARR-TRR-RQAREQTGKMADHLEGLSSDDEETSTDITNFNLEK--DR ISKESSKVFEDVLESFYSIDCIKSQFEAWRSRYYTSYKDAYIGLCLPKLF NPLIRLQLLTWTPLE----------------------------------- -AKCRDFENMLWFESLLFYGCEERE--QEREDVDIALLPTIVEKVILPKL TVIAEHMWDPFSTT--------------QTSRMVGITLKLVNGYPSVANA ENKN-----TQVYLKALLLRMRRTLDDDVFMPLYPKNVLENKNSGPYLFF QRQFWSSVKLLGNFLQWYGIFSNKTLQELSIDGLLNRYILMAFQNSEYGD DSIKKAQNVINCFPKQWFMNLKGERTISQLENFCRYLVHLADTIYRNSIG CSDVEKRNARENIKQIIKLLASVHALDHAVAVAGEH-------------- --N------------VKEFKSLVEGKxx >ENSSHAP00000009379 -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ---MF--------------------------------------------- ----------------------------------------RKARRVNVRK RNDSEEEE-------RER-------------------------------- -----------------------------------DEDxx---------- ------------------------------xx------------------ -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- --------------x----------------------------------- -------------------------------------------------- -xx----------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- --------xx---------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ---------------------------------------------xxxxx xxxx--xxx----------------------------------------- -------------------------------------------------- -------------------------------------------------- -----x-------------------------------------------- -------------------------------------------------- ----------------------xxxxxxxxxxxxxxxxxxxxxxxxxxxx x--xxxx------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ---xxxxSxxxxxxxxxRKRPRENKE--AP-------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ----------RAS-----------------------------------LL SF-QDE-EE-ET-------------------------------------- -----------------------------------------------E-- ------EVFKVKKSSYSKKIVKLLKKEYKE-------------------- --------------------------------DLEKSK------------ -------------------------------------------------- -------------------------------------------------- -VKTELN-----------S------------------------------- ---------SADAEQPLDKSGQPKDPNLEDGAIICEHGEEEMEVES---- EKEEE--------------------------------------------- ---------KPKV-GGTFS------------------------------- ---------------------------NALSSLNVLRP-----------G EIPDAAFIHAARKKRQMARELGDFAP-HDHE-PGKGRLVR-ED--ENDA- SD-DDDDDEKRRIVFSVKEKSQRQKIAEE--I---GIEGSDDEALV-TGE QDEELSRWEQEQIRKGINIPQVQASQPAEV-NMYYQNTYQTIPYGSSYGI PYSY--TAY-----------------------------GSS-EAKSQKTD NTVPFKTPSNEMTPVTIDLVKKQLKD-R---------------------- ------------------------------------------LDSLKELH KANRQQHEKHLQSRVDSTRAIERLEGSSGGIGERYKFLQEMRGYVQDLLE CFSEKVPLINELESAMHQLYKQRASRLVQRRQDDIKDESSEFSSHS---- ---------------NKALMAPNLDSFGRDRALYQEHAK-RRIAERE--- ---ARR-TRR-RQAREQTGKMADHLEGLSSDDEETSTDITNFSLER--DR ISKESSKIFEDVLESFYSIDCIKSQFEAWRSKYFTSYKDAYIGLCLPKLF NPLIRLQLLTWTPLE----------------------------------- -AKCRDFESMLWFESLLFYGCEEQE--QEKEDVDVALLPTIVEKVILPKL -------------xxxxxxxxxxxxxYxQTSRMVGITLKLTSGYPSVVNA ENKN-----TQLYLKALLLRMRRTLDDDVFMPLYPKNILENKNSGPYLFF QRQFWSSVKLLGNFLQWYGIFSNKTLQELSIDGLLNRYILMAFQNSEYGD DSIKKAQHVINCFPKQWFVNLKGERTICQLENFCRYLVHLADTIYRNSIG CSDVEKRNARENIKQIVKLLASVRALDHATTVANDH-------------- --N------------MKELKTLIEGK-- >ENSPCIP00000021601 -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ---MF--------------------------------------------- ----------------------------------------RKARRVNVRK RNDSEEEE-------RER-------------------------------- -----------------------------------EEDxx---------- ------------------------------xx------------------ -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- --------------x----------------------------------- -------------------------------------------------- -xx----------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- --------xx---------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ---------------------------------------------xxxxx xxxx--xxx----------------------------------------- -------------------------------------------------- -------------------------------------------------- -----x-------------------------------------------- -------------------------------------------------- ----------------------xxxxxxxxxxxxxxxxxxxxxxxxxxxx x--xxxx------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ---xxxxSxxxxxxxxxRKRPRENKE--AP-------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ----------RAS-----------------------------------LL SF-QDE-EE-ET-------------------------------------- -----------------------------------------------E-- ------EVFKVKKSSYSKKIVKLLKKEYKE-------------------- --------------------------------DLEKSK------------ -------------------------------------------------- -------------------------------------------------- -VKTELN-----------S------------------------------- ---------SADAEQSLDKAGQPKDPNLEDGAIICEHGEEEMEVES---- EKEEE--------------------------------------------- ---------KPKV-GGTFS------------------------------- ---------------------------NALSSLNVLRP-----------G EIPDAAFIHAARKKRQMARELGDFAP-HEHE-PGKGRLVR-ED--ENDA- SD-DDDDDEKRRIVFSVKEKSQRQKIAEE--I---GIEGSDDEALV-TGE QDEELSRWEQEQIRKGINIPQVQASQPAEV-NMYYQNTYQTMPYGSSYGI PYSY--TAY-----------------------------GSS-EAKSQKTD NTVPFKTPSNEMTPVTIDLVKKQLKD-R---------------------- ------------------------------------------LDSLKELH KANRQQHEKHLQSRVDSTRAIERLEGSSGGIGERYKFLQEMRGYVQDLLE CFSEKVPLINELESAMHQLYKQRASRLVQRRQDDIKDESSEFSSHS---- ---------------NKALMAPNLDSFGRDRALYQEHAK-RRIAERE--- ---ARR-TRR-RQAREQTGKMADHLEGLSSDDEETSTDITNFSLER--DR ISKESSKVFEDVLESFYSIDCIKSQFEAWRSKYFTSYKDAYIGLCLPKLF NPLIRLQLLTWTPLE----------------------------------- -AKCRDFESMLWFESLLFYGCEEQE--QEKEDVDVALLPTIVEKVILPKL TGIAENTWDPFSTT--------------QTSRMVGITLKLTSGYPSVVNA ENKN-----TQLYLKALLLRMRRTLDDDVFMPLYPKNILENKNSGPYLFF QRQFWSSVKLLGNFLQWYGIFSNKTLQELSIDGLLNRYILMAFQNSEYGD DSIKKAQHVINCFPKQWFVNLKGERTICQLENFCRYLVHLADTIYRNSIG CSDVEKRNARENIKQIVKLLASVRALDHAMTVANDH-------------- --N------------MKELKALIEGK-- >ENSOANP00000011037 -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- --------E-EA-------------------------------------- -----------------------------------------------E-- ------EVFKVKKSSYSKKIVKLLKKEYKE-------------------- --------------------------------DLEKSK------------ -------------------------------------------------- -------------------------------------------------- -VKTDLN-----------S------------------------------- ---------LPDSEPPLTKAGHVKDSSQEDGAGASEHGEEEMEVES---- EKEEE--------------------------------------------- ---------KPKT-GGAFS------------------------------- ---------------------------SALSSLNVLRP-----------G EIPDAAFIHAARKKRQLARELGDFTP-HENE-AGKGRLVR-ED--ENDA- SD-DEDDDEKRRIVFSVKEKSQRQKIAEE--I---GIEGSDDEALV-AGE QDEELSRWEQEQIRKGINIPQVQASQPAEV-SAYYQNSYQAMPYGSSFAI PYAY--GAF-----------------------------GSS-EAKSPKTD NSVPFKSPSNEMTPVTIDLVKKQLKD-R---------------------- ------------------------------------------LDSMKEVH RANRQQYEKHEQSRADSTRTIERLEGSSGGIGERYRFLQEMRGYVQDLLE CFSEKVPLINELESAMHQLYKQRASRLVQRRQDDIKDESSEFSSHSxxxx xxxxxxxxxxxLSFL---------------RALYQEHAK-RRIAERA--- -----x-TRR-RQAREQLGKMTDHLEGLSSDDEETSTDITNFNLER--DR ISRESSKVFEDVLESFYSIDCIKSQFEIWRSKYFTSYKDAYIGLCLPKLF HPLIRLQLLSWTPLE----------------------------------- -AKCRDFESMLWFESLLFYGCEEQE--QEKEDADVALLPTIVEKVILPKL TGIAENTWDPFSTT--------------QTSRMVGITLKLINGYPSVVNA ENKN-----TQVYLKALLLRMRRTLDDDVFMPLYPKNILENKNSGPYLFF QRQFWSSVKLLGNFLQWYGILSNKTLQELSIDGLLNRYILMAFQNSECGD DSIKKAQNVINCFPKQWFVNLKGEKTVSQLENFCRYLVHLADTIYRNSIG CSDVEKRNARENIKQIIKLLASIRALDHALTVANDH-------------- --N------------VKELKTLIEGK-- >ENSLCOP00000004434 -------------------------------------------------- -------------------------------------------------- ----------------------------------xxxx------------ -------------------------------------------------- -xx----------------xxxxxx------------------------- ------------------------------------------------xx x------------------------------------------------- -xGMF--------------------------------------------- ----------------------------------------RKARRVNVRK RNDSEEED-------Exx-------------------------------- -----------------------------------DEE------------ ------------------------------xx----xxx----------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -----xxxxxx--------------------------------------- -----------------------xxxxxxxxxxxx--------------- ---------xxxx------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ---------------------------------------xxxxxx----- ----------------xxxx-----------------------xxxxxxx xx------------------------------------------------ -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -xxxxxxxxxx-------------------------xx------------ -----------------xKRPRxNxx--xx-------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ----------RAS-----------------------------------LL SF-QDE-xE-ET-------------------------------------- -----------------------------------------------E-- ------EVFKVKKSSYSKKIVKQLKKEYKE-------------------- --------------------------------DLEKSK------------ -------------------------------------------------- -------------------------------------------------- -VRTEVN-----------S------------------------------- ---------PTDVEAPLEKTGQNKDLGQEDGTANSEHGEEEMEVES---- EKEDE--------------------------------------------- ---------KPKA-GGAFS------------------------------- ---------------------------NALSSLNVLRP-----------G EIPDAAFIHAARKKRQMARELGDFTP-VESE-PGKGRLVR-ED--ENDA- SD-DEDDDEKRRIVFTVKEKSQRQKIAEE--I---GIEGSDDEALV-AGE QDEELSRWEQEQIRKGINIPQVQPSQPAEVxNLYYQNTYQTLSYGSSYGI PYTY--AAY-----------------------------GSS-ETKSQKTD NTVPFKTPSNEMTPVTIDLVKKQLKD-R---------------------- ------------------------------------------LDSMKEMH KANRQQYEKHQQSREDSTKAIERLEGSSGGIGEQYKFLQEMRGYVQDLLE CFSEKVPLINELESAMHQLYKQRASRLVQRRQDDIKDESSEFSSHS---- ---------------NKALMAPNLDSFGRDRVIYQEQVK-RRTAERE--- ---ARR-ARR-RQAREQTGKMADHLEGLSSDDEETSTDITNFNLER--DR ILKESSKVFEDVLESFYSIDCIKSQFEAWRSKYFASYKDAYIGLCLPKLF NPLIRLQLLIWTPLE----------------------------------- -GKCRDFETMLWFESLLFYGCEEQE--QVKDDADISLLPTIVERVVLPKL TVISENIWDPFSTT--------------QTSRMVAIVQKLVDGYPSVVNA ENKN-----TQMLLKALLLRMRRTLDDDVFMPLYPKNILENKNSGPYLFF QRQFWSSVKLLGNFLQWYGILSNKTLQELSIDGLLNRYILMAFQNSEYGE DSIKKAQSVIACFPKQWFSNLKGDKTISQLENFCRYLVHLADTIYRNSIG CSDVEKRNAREHIKQIIKLLASIRALDHAVTVANDH-------------- --N------------VKELKILIEGK-- >ENSMVIP00005007768 x-----------------xxx----------------------------- -------------------------------------------------- ------------------------------xxxx---------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ----------ET-------------------------------------- -----------------------------------------------E-- ------EVFKVKKSSYSKKIVKQLKKEYKE-------------------- --------------------------------DLEKSK------------ -------------------------------------------------- -------------------------------------------------- -VRTEVN-----------S------------------------------- ---------PTAVEAPLEKTGQNKDLGQEDGTANSEHGEEEMEVES---- EKEDE--------------------------------------------- ---------KPKA-GGAFS------------------------------- ---------------------------NALSSLNVLRP-----------G EIPDAAFIHAARKKRQMARELGDFTP-VESE-PGKGRLVR-ED--ENDA- SD-DEDDDEKRRIVFTVKEKSQRQKIAEE--I---GIEGSDDEALV-AGE QDEELSRWEQEQIRKGINIPQVQPSQPAEVxNLYYQNTYQTLSYGSSYGI PYTY--AAY-----------------------------GSS-ETKAQKTD NTVPFKTPSNEMTPVTIDLVKKQLKD-R---------------------- ------------------------------------------LDSMKEMH KANRQQYEKHQQSREDSTKAIERLEGSSGGIGEQYKFLQEMRGYVQDLLE CFSEKVPLINELESAMHQLYKQRASRLVQRRQDDIKDESSEFSSHS---- ---------------NKALMAPNLDSFGRDRVIYQEQVK-RRTAERE--- ---ARR-ARR-RQAREQTGKMADHLEGLSSDDEETSTDITNFNLER--DR ILKESSKVFEDVLESFYSIDCIKSQFEAWRSKYFASYKDAYIGLCLPKLF NPLIRLQLLIWTPLE----------------------------------- -GKCRDFETMLWFESLLFYGCEEQE--QVKDDADISLLPTIVERVVLPKL TVISENIWDPFSTT--------------QTSRMVAIVQKLVDGYPSVVNA ENKN-----TQMLLKALLLRMRRTLDDDVFMPLYPKNILENKNSGPYLFF QRQFWSSVKLLGNFLQWYGILSNKTLQELSIDGLLNRYILMAFQNSEYGE DSIKKAQSVIACFPKQWFSNLKGDKTISQLENFCRYLVHLADTIYRNSIG CSDVEKRNAREHIKQIIKLLASIRALDHAVTVANDH-------------- --N------------VKELKILIEGK-- >ENSCPUP00000018338 -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx xxGMF--------------------------------------------- ----------------------------------------RKARRVNVRK RNDSEEED-------Exx-------------------------------- -----------------------------------DEE------------ ------------------------------xx----xxxxxxxxxxxxxx xxxxxxxxx----------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx xxxxxx-------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ----------ET-------------------------------------- -----------------------------------------------E-- ------EVFKVKKSSYSKKIVKQLKKEYKE-------------------- --------------------------------DLEKSK------------ -------------------------------------------------- -------------------------------------------------- -VRTEVN-----------S------------------------------- ---------PTDVEPPLEKTGQIKDIGQEDGTANSEHGEEEMEVES---- EKEEE--------------------------------------------- ---------KPKA-GGAFS------------------------------- ---------------------------SALSSLNVLRP-----------G EIPDAAFIHAARKKRQMARELGDFTP-VDSE-PGKGRLVR-ED--ENDA- SD-DEDDDEKRRIVFAVKEKSQRQKIAEE--I---GIEGSDDEALV-AGE QDEELSRWEQEQIRKGINIPQVQPSQPAEVxNLYYQNTYQTLSYGSSYGI PYTY--AAY-----------------------------GSS-ETKSQKTD NTVPFKTPSNEMTPVTIDLVKKQLKD-R---------------------- ------------------------------------------LDSMKELH KANRQQYEKHQQSREDSTKAIERLEGSSGGIGEQYKFLQEMRGYVQDLLE CFSEKVPLINELESAMHQLYKQRASRLVQRRQDDIKDESSEFSSHS---- ---------------NKALMAPNLESFGRDRVIYQEQVK-RRTAERE--- ---ARR-TRR-RQAREQTGKMADHLEGLSSDDEETSTDITNFNMER--DR ILKESSKVFEDVLESFYSIDCIKSQFEAWRSKYFASYKDAYIGLCLPKLF NPLIRLQLLIWTPLE----------------------------------- -GKCRDFETMLWFESLLFYGCEEQE--QVKDDADISLLPTIVERVVLPKL TVISENIWDPFSTT--------------QTSRMVAIVQKLVDGYPSVVNA ENKN-----TQMLLKALLLRMRRTLDDDVFMPLYPKNILENKNSGPYLFF QRQFWSSVKLLGNFLQWYGILSNKTLQELSIDGLLNRYILMAFQNSEYGE DSIKKAQSVIACFPKQWFANLKGDKTISQLENFCRYLVHLADTIYRNSIG CSDVEKRNAREHIKQIIKLLASIRALDHAVTVANDH-------------- --N------------VKELKILIEGK-- >ENSTGUP00000013981 -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ------------xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx--- ----------------------xxxxxxxxxxxx---------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- --------------------------------xxxx-------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- --------xx---------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -----x-------------------------------------------- -------------------------------------------------- -------------------------------------------------- --------------xxx-------xxxx---------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -xxxxxxxxxx-------------------------xx------------ -----------------KKRSRENKE--VP-------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ----------RAS-----------------------------------LL SF-QDE-EE-ET-------------------------------------- -----------------------------------------------E-- ------EVFKVKKSSYSKKIVKQLKKEYKE-------------------- --------------------------------DLEKSK------------ -------------------------------------------------- -------------------------------------------------- -VRTEVN-----------S------------------------------- ---------PTDVEAPLEKIGQNKDVGQEDGTANSEHGEEEMEVES---- EKEEE--------------------------------------------- ---------KPKA-GGAFS------------------------------- ---------------------------SALSSLNVLRP-----------G EIPDAAFIHAARKKRQMARELGDFTP-VDSE-PGKSRLVR-ED--ENDA- SD-DEDDDEKRRIVFTVKEKSQRQKIAEE--I---GIEGSDDEALV-AGE QDEELSRWEQEQIRKGINIPQVQPSQPAEVxNVYYQNTYQTLSYGSSYGI PYTY--AAY-----------------------------GSS-ETKSQKTD NTVPFKTPSNEMTPVTIDLVKKQLKD-R---------------------- ------------------------------------------LDSMKEMH KANRQQYEKHQQSQEDSTKAIERLEGSSGGIGERYKFLQEMRGYVQDLLE CFSEKVPLINELESAMHQLYKQRASRLVQRRQDDIKDESSEFSSHS---- ---------------NKALMAPNLDSFGRDRVIYQEQVK-RRTAERE--- ---ARR-ARR-RQAREQTGKMADHLEGLSSDDEETSTDITNFNLER--DR ILKESSKVFEDVLESFYSIDCIKSQFEAWRSKYFASYKDAYIGLCLPKLF NPLIRLQLLTWTPLE----------------------------------- -GKCRDFETMLWFESLLFYGCEEQE--QVKDDADISLLPTIVERVVLPKL TVISENIWDPFSTT--------------QTSRMVAIVQKLIDGYPSVVNA ENKN-----TQMLLKALLLRMRRTLDDDVFMPLYPKNILENKNSGPYLFF QRQFWSSVKLLGNFLQWYGILSNKTLQELSIDGLLNRYILMAFQNSEYGE DSIKKAQSVIACFPKQWFTNLTGDKTISQLENFCRYLVHLADTIYRNSIG CSDVEKRNAREHIKQIVKLLASIRALDHAVTVANDH-------------- --N------------VKEFKILIEGK-- >ENSZALP00000019428 -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ---MF--------------------------------------------- ----------------------------------------RKARRVNVRK RNDSEEED-------EER-------------------------------- -----------------------------------DEE------------ ------------------------------xx----xxxx---------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- --------------xx------------------xxxxxxxxxxxxxxxx xxxxxxxxxxxxxxxxxxxxPAAFACxxxxxxxxxxxxxxxxxxxxxx-- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ----------------------------------------------xxxx xxxxx--xxx---------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -----x-------------------------------------------- -------------------------------------------------- -------------------------------------------------- --------------xxx-------xxxx---------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -xxxxxxxxxx-------------------------xx------------ -----------------KKKSRENKE--VP-------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ----------RAS-----------------------------------LL SF-QDE-EE-ET-------------------------------------- -----------------------------------------------E-- ------EVFKVKKSSYSKKIVKQLKKEYKE-------------------- --------------------------------DLEKSK------------ -------------------------------------------------- -------------------------------------------------- -VRTEAN-----------S------------------------------- ---------PTDAEAPPEKVGQNKDIGQEDGTANSEHGEEEMEVES---- EKEEE--------------------------------------------- ---------KPKA-GGAFS------------------------------- ---------------------------SALSSLNVLRP-----------G EIPDAAFIHAARKKRQMARELGDFTP-VDSE-PGKGRLVR-ED--ENDA- SD-DEDDDEKRRIVFTVKEKSQRQKIAEE--I---GIEGSDDEALV-AGE QDEELSRWEQEQIRKGINIPQVQPSQPAEVxNVYYQNTYQTLSYGSSYGI PYTY--AAY-----------------------------GSS-ETKSQKTD NTVPFKTPSNEMTPVTIDLVKKQLKD-R---------------------- ------------------------------------------LDSMKEMH KANRQQYEKHQQSQEDSTKAIERLEGSSGGIGERYKFLQEMRGYVQDLLE CFSEKVPLINELESAMHQLYKQRASRLVQRRQDDIKDESSEFSSHS---- ---------------NKALMAPNLDSFGRDRVIYQEQVK-RRTAERE--- ---ARR-ARR-RQAREQTGKMADHLEGLSSDDEETSTDITNFNLER--DR ILKESSKVFEDVLESFYSIDCIKSQFEAWRSKYFASYKDAYIGLCLPKLF NPLIRLQLLTWTPLE----------------------------------- -GKCRDFETMLWFESLLFYGCEEQE--QVKDDADISLLPTIVERVVLPKL TVISENIWDPFSTT--------------QTSRMVAIVQKLIDGYPSVVNA ENKN-----TQMLLKALLLRMRRTLDDDVFMPLYPKNILENKNSGPYLFF QRQFWSSVKLLGNFLQWYGILSNKTLQELSIDGLLNRYILMAFQNSEYGE DSIKKAQSVIACFPKQWFTNLTGDKTISQLENFCRYLVHLADTIYRNSIG CSDVEKRNAREHIKQIIKLLASVRALDHAVTVANDH-------------- --N------------VKEFKILIEGK-- >ENSJHYP00000012362 -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ---MF--------------------------------------------- ----------------------------------------RKARRVNVRK RNDSEEED-------EER-------------------------------- -----------------------------------DEE------------ ------------------------------xx----xxxx---------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- --------------xx------------------xxxxxxxxxxxxxxxx xxxxxxxxxxxxxxxxxxxxPAAFACxxxxxxxxxxxxxxxxxxxxxx-- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ----------------------------------------------xxxx xxxxx--xxx---------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -----x-------------------------------------------- -------------------------------------------------- -------------------------------------------------- --------------xxx-------xxxx---------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -xxxxxxxxxx-------------------------xx------------ -----------------KKKSRENKE--VP-------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ----------RAS-----------------------------------LL SF-QDE-EE-ET-------------------------------------- -----------------------------------------------E-- ------EVFKVKKSSYSKKIVKQLKKEYKE-------------------- --------------------------------DLEKSK------------ -------------------------------------------------- -------------------------------------------------- -VRTEAN-----------S------------------------------- ---------PTDAEAPPEKVGQNKDIGQEDGTANSEHGEEEMEVES---- EKEEE--------------------------------------------- ---------KPKA-GGAFS------------------------------- ---------------------------SALSSLNVLRP-----------G EIPDAAFIHAARKKRQMARELGDFTP-VDSE-PGKGRLVR-ED--ENDA- SD-DEDDDEKRRIVFTVKEKSQRQKIAEE--I---GIEGSDDEALV-AGE QDEELSRWEQEQIRKGINIPQVQPSQPAEVxNVYYQNTYQTLSYGSSYGI PYTY--AAY-----------------------------GSS-ETKSQKTD NTVPFKTPSNEMTPVTIDLVKKQLKD-R---------------------- ------------------------------------------LDSMKEMH KANRQQYEKHQQSQEDSTKAIERLEGSSGGIGERYKFLQEMRGYVQDLLE CFSEKVPLINELESAMHQLYKQRASRLVQRRQDDIKDESSEFSSHS---- ---------------NKALMAPNLDSFGRDRVIYQEQVK-RRTAERE--- ---ARR-ARR-RQAREQTGKMADHLEGLSSDDEETSTDITNFNLER--DR ILKESSKVFEDVLESFYSIDCIKSQFEAWRSKYFASYKDAYIGLCLPKLF NPLIRLQLLTWTPLE----------------------------------- -GKCRDFETMLWFESLLFYGCEEQE--QVKDDADISLLPTIVERVVLPKL TVISENIWDPFSTT--------------QTSRMVAIVQKLIDGYPSVVNA ENKN-----TQMLLKALLLRMRRTLDDDVFMPLYPKNILENKNSGPYLFF QRQFWSSVKLLGNFLQWYGILSNKTLQELSIDGLLNRYILMAFQNSEYGE DSIKKAQSVIACFPKQWFTNLTGDKTISQLENFCRYLVHLADTIYRNSIG CSDVEKRNAREHIKQIIKLLASVRALDHAVTVANDH-------------- --N------------VKEFKILIEGK-- >ENSSCAP00000023268 -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- --------------------------------------xxxxxxxxxx-- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ----------------------------------------------xxxx xxx----------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------x------------ -----------------KKRSRENKE--VP-------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ----------RAS-----------------------------------LL SF-QDE-EE-ET-------------------------------------- -----------------------------------------------E-- ------EVFKVKKSSYSKKIVKQLKKEYKE-------------------- --------------------------------DLEKSK------------ -------------------------------------------------- -------------------------------------------------- -VRTEAN-----------S------------------------------- ---------PTDVEAPPEKIGQNKDIGQEDGTANSEHGEEEMEVES---- EKEEE--------------------------------------------- ---------KPKA-GGAFS------------------------------- ---------------------------SALSSLNVLRP-----------G EIPDAAFIHAARKKRQMARELGDFTP-VDSE-PGKGRLVR-ED--ENDA- SD-DEDDDEKRRIVFTVKEKSQRQKIAEE--I---GIEGSDDEALV-AGE QDEELSRWEQEQIRKGINIPQVQPSQPAEVxNVYYQNTYQTLSYGSSYGI PYTY--AAY-----------------------------GSS-ETKSQKTD NTVPFKTPSNEMTPVTIDLVKKQLKD-R---------------------- ------------------------------------------LDSMKEMH KANRQQYEKHQQSQEDSTKAIERLEGSSGGIGERYKFLQEMRGYVQDLLE CFSEKVPLINELESAMHQLYKQRASRLVQRRQDDIKDESSEFSSHS---- ---------------NKALMAPNLDSFGRDRVIYQEQVK-RRTAERE--- ---ARR-ARR-RQAREQTGKMADHLEGLSSDDEETSTDITNFNLER--DR ILKESSKVFEDVLESFYSIDCIKSQFEAWRSKYFASYKDAYIGLCLPKLF NPLIRLQLLTWTPLE----------------------------------- -GKCRDFETMLWFESLLFYGCEEQE--QVKDDADISLLPTIVERVVLPKL TVISENIWDPFSTT--------------QTSRMVAIVQKLIDGYPSVVNA ENKN-----TQMLLKALLLRMRRTLDDDVFMPLYPKNILENKNSGPYLFF QRQFWSSVKLLGNFLQWYGILSNKTLQELSIDGLLNRYILMAFQNSEYGE DSIKKAQSVIACFPKQWFTNLTGDKTISQLENFCRYLVHLADTIYRNSIG CSDVEKRNAREHIKQIIKLLASIRALDHAVTVANDH-------------- --N------------VKEFKILIEGK-- >ENSPMJP00000015850 -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ---MF--------------------------------------------- ----------------------------------------RKARRVNVRK RNDSEEED-------EER-------------------------------- -----------------------------------DEE------------ ------------------------------xx----xxxx---------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- --------------xx------------------xxxxxxxxxxxxxxxx xxxxxxxxxxxxxxxxxxxxPAAFACxxxxxxxxxxxxxxxxxxxxxx-- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ----------------------------------------------xxxx xxxxx--xxx---------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -----x-------------------------------------------- -------------------------------------------------- -------------------------------------------------- --------------xxx-------xxxx---------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -xxxxxxxxxx-------------------------xx------------ -----------------KKRSRENKE--VP-------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ----------RAS-----------------------------------LL SF-QDE-EE-ET-------------------------------------- -----------------------------------------------E-- ------EVFKVKKSSYSKKIVKQLKKEYKE-------------------- --------------------------------DLEKSK------------ -------------------------------------------------- -------------------------------------------------- -VRTEVN-----------S------------------------------- ---------PTDVEAPLEKTGQNKDIGQEDGTANSEHGEEEMEVES---- EKEEE--------------------------------------------- ---------KPKA-GGAFS------------------------------- ---------------------------SALSSLNVLRP-----------G EIPDAAFIHAARKKRQMARELGDFTP-VDSE-PGKSRLVR-ED--ENDA- SD-DEDDDEKRRIVFTVKEKSQRQKIAEE--I---GIEGSDDEALV-AGE QDEELSRWEQEQIRKGINIPQVQPSQPAEVxNVYYQNTYQTLSYGSSYGI PYTY--AAY-----------------------------GSS-ENKSQKTD NTVPFKTPSNEMTPVTIDLVKKQLKD-R---------------------- ------------------------------------------LDSMKEIH KANRQQYEKHQQSQEDSTKAIERLEGSSGGIGERYKFLQEMRGYVQDLLE CFSEKVPLINELESAMHQLYKQRASRLVQRRQDDIKDESSEFSSHS---- ---------------NKALMAPNLDSFGRDRVIYQEQVK-RRTAERE--- ---ARR-ARR-RQAREQTGKMADHLEGLSSDDEETSTDITNFNLER--DR ILKESSKVFEDVLESFYSIDCIKSQFEAWRSKYFASYKDAYIGLCLPKLF NPLIRLQLLTWTPLE----------------------------------- -GKCRDFETMLWFESLLFYGCEEQE--QVKDDADISLLPTIVERVVLPKL TVISENIWDPFSTT--------------QTSRMVAIVQKLIDGYPSVVNA ENKN-----TQMLLKALLLRMRRTLDDDVFMPLYPKNILENKNSGPYLFF QRQFWSSVKLLGNFLQWYGILSNKTLQELSIDGLLNRYILMAFQNSEYGE DSIKKAQSVIACFPKQWFTNLTGDKTISQLENFCRYLVHLADTIYRNSIG SSDVEKRNAREHIKQIIKLLASIRALDHAITVANDH-------------- --N------------VKEFKILIEGK-- >ENSCCEP00000004320 -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ---------------------RENKE--VP-------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ----------RAS-----------------------------------LL SF-QDE-EE-ET-------------------------------------- -----------------------------------------------E-- ------EVFKVKKSSYSKKIVKQLKKEYKE-------------------- --------------------------------DLEKSK------------ -------------------------------------------------- -------------------------------------------------- -VRTEVN-----------S------------------------------- ---------PTDVEAPLEKTGQNKDIGQEDGTANSEHGEEEMEVES---- EKEEE--------------------------------------------- ---------KPKA-GGAFS------------------------------- ---------------------------SALSSLNVLRP-----------G EIPDAAFIHAARKKRQMARELGDFTP-VDSE-PGKSRLVR-ED--ENDA- SD-DEDDDEKRRIVFTVKEKSQRQKIAEE--I---GIEGSDDEALV-AGE QDEELSRWEQEQIRKGINIPQVQPSQPAEVxNVYYQNTYQTLSYGSSYGI PYTY--AAY-----------------------------GSS-ENKSQKTD NTVPFKTPSNEMTPVTIDLVKKQLKD-R---------------------- ------------------------------------------LDSMKEIH KANRQQYEKHQQSQEDSTKAIERLEGSSGGIGERYKFLQEMRGYVQDLLE CFSEKVPLINELESAMHQLYKQRASRLVQRRQDDIKDESSEFSSHS---- ---------------NKALMAPNLDSFGRDRVIYQEQVK-RRTAERE--- ---ARR-ARR-RQAREQTGKMADHLEGLSSDDEETSTDITNFNLER--DR ILKESSKVFEDVLESFYSIDCIKSQFEAWRSKYFASYKDAYIGLCLPKLF NPLIRLQLLTWTPLE----------------------------------- -GKCRDFETMLWFESLLFYGCEEQE--QVKDDADISLLPTIVERVVLPKL TVISENIWDPFSTT--------------QTSRMVAIVQKLIDGYPSVVNA ENKN-----TQMLLKALLLRMRRTLDDDVFMPLYPKNILENKNSGPYLFF QRQFWSSVKLLGNFLQWYGILSNKTLQELSIDGLLNRYILMAFQNSEYGE DSIKKAQSVIACFPKQWFTNLTGDKTISQLENFCRYLVHLADTIYRNSIG SSDVEKRN---HIKQIIKLLASVRALDHAITVANDH-------------- --N------------VKEFKILIEGK-- >ENSLSDP00000002704 -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ---MF--------------------------------------------- ----------------------------------------RKARRVNVRK RNDSEEED-------EER-------------------------------- -----------------------------------DEE------------ ------------------------------xx----xxxxx--------- ------xxxxx--------------------------------------- ---------xxxx------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ----------------------------------xxxx------------ -------------------------------------------------- -------------------------------------------------- --------------x----------------------------------- -xxxxxxxxxxxxxxxxxxxPAAFACxxxxxxxxxxxxxxxxxxxxxx-- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ----------------------------------------------xxxx xxxxx--xxx---------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------xxx---------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -xxxxxxxxxx-------------------------xx------------ -----------------KKRSRENKE--VP-------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ----------RAS-----------------------------------LL SF-QDE-EE-ET-------------------------------------- -----------------------------------------------E-- ------EVFKVKKSSYSKKIVKQLKKEYKE-------------------- --------------------------------DLEKSK------------ -------------------------------------------------- -------------------------------------------------- -VRTEVN-----------S------------------------------- ---------PTDVEAPLEKIGQNKDIGQEDGTANSEHGEEEMEVES---- EKEEE--------------------------------------------- ---------KPKA-GGAFS------------------------------- ---------------------------SALSSLNVLRP-----------G EIPDAAFIHAARKKRQMARELGDFTP-VDSE-PGKSRLVR-ED--ENDA- SD-DEDDDEKRRIVFTVKEKSQRQKIAEE--I---GIEGSDDEALV-AGE QDEELSRWEQEQIRKGINIPQVQPSQPAEVxNVYYQNTYQTLSYGSSYGI PYTY--AAY-----------------------------GSS-ETKSQKTD NTVPFKTPSNEMTPVTIDLVKKQLKD-R---------------------- ------------------------------------------LDSMKEMH KANRQQYEKHQQSQEDSTKAIERLEGSSGGIGERYKFLQEMRGYVQDLLE CFSEKVPLINELESAMHQLYKQRASRLVQRRQDDIKDESSEFSSHS---- ---------------NKALMAPNLDSFGRDRVIYQEQVK-RRTAERE--- ---ARR-ARR-RQAREQTGKMADHLEGLSSDDEETSTDITNFNLER--DR ILKESSKVFEDVLESFYSIDCIKSQFEAWRSKYFASYKDAYIGLCLPKLF NPLIRLQLLTWTPLE----------------------------------- -GKCRDFETMLWFESLLFYGCEEQE--QVKDDADISLLPTIVERVVLPKL TVISENIWDPFSTT--------------QTSRMVAIVQKLIDGYPSVVNA ENKN-----TQMLLKALLLRMRRTLDDDVFMPLYPKNILENKNSGPYLFF QRQFWSSVKLLGNFLQWYGILSNKTLQELSIDGLLNRYILMAFQNSEYGE DSIKKAQSVIACFPKQWFTNLTGDKTISQLENFCRYLVHLADTIYRNSIG CSDVEKRNAREHIKQIVKLLASIRALDHAVTVANDH-------------- --N------------VKEFKILIEGK-- >ENSFALP00000006587 -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------xxx---------- -------------x-------------------------xxxxxxxxxxx xxxxxxxxxxxxxxxxxxxxxxxxxxx--------------xxx------ -------------xx----------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- --------xx---------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -----x-------------------------------------------- -------------------------------------------------- -------------------------------------------------- --------------xxx-------xxxx---------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -xxxxxxxxxx-------------------------xx------------ -----------------KKRSRENKE--VP-------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ----------RAS-----------------------------------LL SF-QDE-EE-ET-------------------------------------- -----------------------------------------------E-- ------EVFKVKKSSYSKKIVKQLKKEYKE-------------------- --------------------------------DLEKSK------------ -------------------------------------------------- -------------------------------------------------- -VRTEVN-----------S------------------------------- ---------PTDVEAPLEKTGQNKDIGQEDGTANSEHGEEEMEVES---- EKEEE--------------------------------------------- ---------KPKA-GGAFS------------------------------- ---------------------------SALSSLNVLRP-----------G EIPDAAFIHAARKKRQMARELGDFTP-VDSE-PGKGRLVR-ED--ENDA- SD-DEDDDEKRRIVFTVKEKSQRQKIAEE--I---GIEGSDDEALV-AGE QDEELSRWEQEQIRKGINIPQVQPSQPAEVxNVYYQNTYQTLSYGSSYGI PYTY--AAY-----------------------------GSS-DTKSQKAD NTVPFKTPSNEMTPVTIDLVKKQLKD-R---------------------- ------------------------------------------LDSMKEMH KANRQQYEKHQQSQEDSTKAIERLEGSSGGIGERYKFLQEMRGYVQDLLE CFSEKVPLINELESAMHQLYKQRASRLVQRRQDDIKDESSEFSSHS---- ---------------NKALMAPNLDSFGRDRVIYQEQVK-RRTAERE--- ---ARR-ARR-RQAREQTGKMADHLEGLSSDDEETSTDITNFNLERVLDR ILKESSKVFEDVLESFYSIDCIKSQFEAWRSKYFASYKDAYIGLCLPKLF NPLIRLQLLTWTPLE----------------------------------- -GKCRDFETMLWFESLLFYGCEEQE--QVKDDADISLLPTIVERVVLPKL TVISENIWDPFSTT--------------QTSRMVAIVQKLIDGYPSVVNA ENKN-----TQMLLKALLLRMRRTLDDDVFMPLYPKNILENKNSGPYLFF QRQFWSSVKLLGNFLQWYGILSNKTLQELSIDGLLNRYILMAFQNSEYGE DSIKKAQSVIACFPKQWFTNLTGDKTISQLENFCRYLVHLADTIYRNSIG CSDVEKRNAREHIKQIIKLLASIRALDHAVTVANDH-------------- --N------------VKEFKILIEGK-- >ENSCPGP00000022834 xxxxxxxxxxxxxxxxxxx------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx xxGMF--------------------------------------------- ----------------------------------------RKARRVNVRK RNDSEEED-------Exx-------------------------------- -----------------------------------DEE------------ ------------------------------xx----xxxxxxxxxxxxxx xxxxxxxx------------------------------------------ -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -xxxxxxxxxxxxxxxxxxxPAAFACxxxxxxxxxxxxxxxxxxxxxx-- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ----------------------------------------------xxxx xxxxx---xx---------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -----x-------------------------------------------- -------------------------------------------------- -------------------------------------------------- --------------xxx-------xxxx---------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -xxxxxxxxxx-------------------------xx------------ -----------------KKRPRENKE--VP-------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ----------RAS-----------------------------------LL SF-QDE-EE-ET-------------------------------------- -----------------------------------------------E-- ------EVFKVKKSSYSKKIVKQLKKEYKE-------------------- --------------------------------DLEKSK------------ -------------------------------------------------- -------------------------------------------------- -VRTEVN-----------S------------------------------- ---------PTDVEPPLEKTGQIKDIGQEDGTANSEHGEEEMEVES---- EKEEE--------------------------------------------- ---------KPKA-GGAFS------------------------------- ---------------------------SALSSLNVLRP-----------G EIPDAAFIHAARKKRQMARELGDFTP-VDSE-PGKGRLVR-ED--ENDA- SD-DEDDDEKRRIVFAVKEKSQRQKIAEE--I---GIEGSDDEALV-AGE QDEELSRWEQEQIRKGINIPQVQPSQPAEVxNLYYQNTYQTLSYGSSYGI PYTY--ATY-----------------------------GSS-ETKSQKTD NTVPFKTPSNEMTPVTIDLVKKQLKD-R---------------------- ------------------------------------------LDSMKELH KANRQQYEKHQQSREDSTKAIERLEGSSGGIGEQYKFLQEMRGYVQDLLE CFSEKVPLINELESAMHQLYKQRASRLVQRRQDDIKDESSEFSSHS---- ---------------NKALMAPNLESFGRDRVIYQEQVK-RRTAERE--- ---ARR-TRR-RQAREQTGKMADHLEGLSSDDEETSTDITNFNMER--DR ILKESSKVFEDVLESFYSIDCIKSQFEAWRSKYFASYKDAYIGLCLPKLF NPLIRLQLLIWTPLE----------------------------------- -GKCRDFETMLWFESLLFYGCEEQE--QVKDDADISLLPTIVERVVLPKL TVISENIWDPFSTT--------------QTSRMVAIVQKLVDGYPSVVNA ENKN-----TQMLLKALLLRMRRTLDDDVFMPLYPKNILENKNSGPYLFF QRQFWSSVKLLGNFLQWYGILSNKTLQELSIDGLLNRYILMAFQNSEYGE DSIKKAQSVIACFPKQWFTNLKGDKTISQLENFCRYLVHLADTIYRNSIG CSDVEKRNAREHIKQIIKLLASIRALDHAVTVANDH-------------- --Nxxxxxxxxxxxx------------- >ENSNMEP00000011923 -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ---MF--------------------------------------------- ----------------------------------------RKARRVNVRK RNDSEEED-------EER-------------------------------- -----------------------------------DEE------------ ------------------------------xx----xxxx---------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- --------------xxxxxxxxxxxxxxxxxxxxx--------------- -xxxxxxxxxxxxxxxxxxxPAAFACxxxxxxxxxxxxxxxxxxxxxx-- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ----------------------------------------------xxxx xxx-x---xx---------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -----x-------------------------------------------- -------------------------------------------------- -------------------------------------------------- --------------xxx-------xxxx---------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -xxxxxxxxxx-------------------------xx------------ -----------------KKRPRENKE--VP-------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ----------RAS-----------------------------------LL SF-QDE-EE-ET-------------------------------------- -----------------------------------------------E-- ------EVFKVKKSSYSKKIVKQLKKEYKE-------------------- --------------------------------DLEKSK------------ -------------------------------------------------- -------------------------------------------------- -VRTEVN-----------S------------------------------- ---------PTDVEPPLEKTGQIKDIGQEDGTANSEHGEEEMEVES---- EKEEE--------------------------------------------- ---------KPKP-GGAFS------------------------------- ---------------------------SALSSLNVLRP-----------G EIPDAAFIHAARKKRQMARELGDFTP-VDSE-PGKSRLVR-ED--ENDA- SD-DEDDDEKRRIVFTVKEKSQRQKIAEE--I---GIEGSDDEALV-AGE QDEELSRWEQEQIRKGINIPQVQPSQPAEVxNLYYQNTYQTLSYGSSYGI PYTY--AAY-----------------------------GSS-ETKSQKTD NTVPFKTPSNEMTPITIDLVKKQLKD-R---------------------- ------------------------------------------LDSMKELH KANRQQFEKHQQSREDSTKAIERLEGSSGGIGEQYKFLQEMRGYVQDLLE CFSEKVPLINELESAMHQLYKQRASRLVQRRQDDIKDESSEFSSHS---- ---------------NKALMAPNLDSFGRDRVLYQEQVK-RRTAERE--- ---ARR-ARR-RQAREQTGKMADHLEGLSSDDEETSTDITNFNMER--DR ILKESSKVFEDVLESFYSIDCIKSQFEAWRSKYFASYKDAYIGLCLPKLF NPLIRLQLLIWTPLE----------------------------------- -GKCRDFETMLWFESLLFYGCEEQE--QEKDDADISLLPTIVERVVLPKL TVISENIWDPFSTT--------------QTSRMVAIVQKLVNGYPSVVNA ENKN-----TQMLLKALLLRMRRTLDDDVFMPLYPKNILENKNSGPYLFF QRQFWSSVKLLGNFLQWYGILSNKTLQELSIDGLLNRYILMAFQNSEYGD DSIKKAQSVIACFPKQWFANLKGDKTISQLENFCRYLVHLADTIYRNSIG CSDVEKRNAREQIKQIIKLLASIRALDHAVTVANDH-------------- --N------------VKELKILIEGK-- >ENSAPLP00000011437 -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ---MF--------------------------------------------- ----------------------------------------RKARRVNVRK RNASEEED-------EER-------------------------------- -----------------------------------DEE------------ ------------------------------xx----xxx----------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------xx----------- -------------xxxxxxxxxxxxxxxxx---xxxxxxxx--------- -------------------------------------------------- -------------------------------------------------- -xxxxxxxxxxxxxxxxxxxPAAFACxxxxxxxxxxxxxxxxxxxxxx-- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ----------------------------------------------xxxx xxxxxxxxxx---------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -----x-------------------------------------------- -------------------------------------------------- -------------------------------------------------- --------------xxx-------xxxx---------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -xxxxxxxxxx-------------------------xx------------ -----------------KKRPREGKE--VP-------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ----------RAS-----------------------------------LL SF-QDE-EE-ET-------------------------------------- -----------------------------------------------E-- ------EVFKVKKSSYSKKIVKQLKKEYKE-------------------- --------------------------------DLEKSK------------ -------------------------------------------------- -------------------------------------------------- -VRTEVN-----------S------------------------------- ---------PTDVEPPLEKTGQIKDIGQEDGTANSEQGEEEMEVES---- EKEEE--------------------------------------------- ---------KPKA-GGAFS------------------------------- ---------------------------SALSSLNVLRP-----------G EIPDAAFIHAARKKRQMARELGDFTP-VDSE-PGKGRLVR-ED--ENDA- SD-DEDDDEKRRIVFTVKEKSQRQKIAEE--I---GIEGSDDEALV-AGE QDEELSRWEQEQIRKGINIPQVQPSQPAEVxNLYYQNTYQTLSYGSSYGI PYTY--ATY-----------------------------GSS-ETKSQKTD NTVPFKTPSNEMTPITIDLVKKQLKD-R---------------------- ------------------------------------------LDSMKELH KANRQQYEKHQQSREDSTKAIERLEGSSGGIGEQYKFLQEMRGYVQDLLE CFSEKVPLINELESAMHQLYKQRASRLVQRRQDDIKDESSEFSSHS---- ---------------NKALMAPNLDSFGRDRVLYQEQVK-RRTAERE--- ---ARR-ARR-RQAREQTGKMADHLEGLSSDDEETSTDITNFNMER--DR ILKESSKVFEDVLESFYSIDCIKSQFEAWRSKYFASYKDAYIGLCLPKLF NPLIRLQLLIWTPLE----------------------------------- -GKCRDFETMLWFESLLFYGCEEQE--QEKDDADISLLPTIVERVVLPKL TVISENIWDPFSTT--------------QTSRMVAIVQKLVDGYPSVVNA ENKN-----TQMLLKALLLRMRRTLDDDVFMPLYPKNILENKNSGPYLFF QRQFWSSVKLLGNFLQWYGILSNKTLQELSIDGLLNRYILMAFQNSEYGD DSIKKAQSVIACFPKQWFANLKGDKTISQLENFCRYLVHLADTIYRNSIG CSDVEKRNAREQIKQIIKLLASIRALDHAMTVANDH-------------- --N------------VKELKILIEGK-- >ENSABRP00000017967 xxxxx--------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- --xxxxxxxxxxxxxxxxxx------------------------------ -------------------------------------------------- -------------------------------------------------- -GGMF--------------------------------------------- ----------------------------------------RKARRVNVRK RNDSEEED-------EER-------------------------------- -----------------------------------xEE------------ ------------------------------xx----xxx----------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------xxx---------- -------------xxxxxxxxxxxxxxxxxxxxxxxxxxxx--------- -------------------------------------------------- -------------------------------------------------- -xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx-- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ----------------------------------------------xxxx xxxxx---xx---------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -----x-------------------------------------------- -------------------------------------------------- -------------------------------------------------- --------------xxx-------xxxx---------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -xxxxxxxxxx-------------------------Kx------------ -----------------KKRPRESKE--VP-------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ----------RAS-----------------------------------LL SF-QDE-EE-ET-------------------------------------- -----------------------------------------------E-- ------EVFKVKKSSYSKKIVKQLKKEYKE-------------------- --------------------------------DLEKSK------------ -------------------------------------------------- -------------------------------------------------- -VRTEVN-----------S------------------------------- ---------PxDxxxxxxxxxxxxxxxxEDGTANSEQGEEEMEVES---- Exxxx--------------------------------------------- ---------KPKA-GGAFS------------------------------- ---------------------------SALSSLNVLRP-----------G EIPDAAFIHAARKKRQMARELGDFTP-VDSE-PGKGRLVR-ED--ENDA- SD-DEDDDEKRRIVFTVKEKSQRQKIAEE--I---GIEGSDDEALV-AGE QDEELSRWEQEQIRKGINIPQVQPSQPAEVxNLYYQNTYQTLSYGSSYGI PYTY--ATY-----------------------------GSS-ETKSQKTD NTVPFKTPSNEMTPITIDLVKKQLKD-R---------------------- ------------------------------------------LDSMKELH KANRQQYEKHQQSREDSTKAIERLEGSSGGIGEQYKFLQEMRGYVQDLLE CFSEKVPLINELESAMHQLYKQRASRLVQRRQDDIKDESSEFSSHS---- ---------------NKALMAPNLDSFGRDRVLYQEQVK-RRTAERE--- ---ARR-ARR-RQAREQTGKMADHLEGLSSDDEETSTDITNFNMER--DR ILKESSKVFEDVLESFYSIDCIKSQFEAWRSKYFASYKDAYIGLCLPKLF NPLIRLQLLIWTPLExLVGLGYPYTLICLVMPWLVVSRQRGRKFSSLLGN QGKCRDFETMLWFESLLFYGCEEQE--QEKDDADISLLPTIVERVVLPKL TVISENIWDPFSTT--------------QTSRMVAIVQKLVDGYPSVVNA ENKN-----TQMLLKALLLRMRRTLDDDVFMPLYPKNILENKNSGPYLFF QRQFWSSVKLLGNFLQWYGILSNKTLQELSIDGLLNRYILMAFQNSEYGD DSIKKAQSVIACFPKQWFANLKGDKTISQLENFCRYLVHLADTIYRNSIG CSDVEKRNAREQIKQIIKLLASIRALDHAMTVANDH-------------- --N------------VKELKILIEGK-- >ENSMUNP00000007643 -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ---M---------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ----------xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx xxxxxxxxxx---------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- --------------------PAAFACxxxxxxxxxxxxxxxxxxxxxx-- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ----------------------------------------------xxxx xxxxx---xx---------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -----x-------------------------------------------- -------------------------------------------------- -------------------------------------------------- --------------xxx-------xxxx---------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -xxxxxxxxxx-------------------------xx------------ -----------------KKRTRENKE--VP-------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ----------RAS-----------------------------------LL SF-QDE-EE-ET-------------------------------------- -----------------------------------------------E-- ------EVFKVKKSSYSKKIVKQLKKEYKE-------------------- --------------------------------DLEKSK------------ -------------------------------------------------- -------------------------------------------------- -VRTEVN-----------S------------------------------- ---------PTDVEPPLEKTGQIKDIGQEDGTANSEHGEEEMEVES---- EKEEE--------------------------------------------- ---------KPKA-GGAFS------------------------------- ---------------------------SALSSLNVLRP-----------G EIPDAAFIHAARKKRQMARELGDFTP-VDSE-PGKGRLVR-ED--ENDA- SD-DEDDDEKRRIVFTVKEKSQRQKIAEE--I---GIEGSDDEALV-AGE QDEELSRWEQEQIRKGINIPQVQPTQPAEVxNLYYQNTYQTLSYGSSYGV PYTY--TAY-----------------------------GSS-ETKSQKTD NTVPFKTPSNEMTPVTIDLVKKQLKD-R---------------------- ------------------------------------------LDSMKELH NANRQQYEKHQQSREDSTKAIERLEGSSGGIGEQYKFLQEMRGYVQDLLE CFSEKVPLINELESAMHQLYKQRASRLVQRRQDDIKDESSEFSSHS---- ---------------NKALMAPNLESFGRDRVIYQEQVK-RRTAERE--- ---ARR-ARR-RQAREQTGKMADHLEGLSSDDEETSTDITNFNMER--DR ILKESSKVFEDVLESFYSIDCIKSQFEAWRSKYFASYKDAYIGLCLPKLF NPLIRLQLLIWTPLE----------------------------------- -GKCRDFETMLWFESLLFYGCEEQE--QVKDDADISLLPTIVERVVLPKL TVISENIWDPFSTT--------------QTSRMVAIVQKLVDGYPSVVNA ENKN-----TQMLLKALLLRMRRTLDDDVFMPLYPKNILENKNSGPYLFF QRQFWSSVKLLGNFLQWYGILSNKTLQELSIDGLLNRYILMAFQNSEYGE DSIKKAQSVIACFPKQWFTNLKGDKTISQLENFCRYLVHLADTIYRNSIG CSDVEKRNAREHIKQIIKLLASIRALDHAVTVANDH-------------- --N------------IKELKILIEGK-- >ENSAOWP00000013056 x------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ---------------------------------xxxxxxxxxxxxxxxxx xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx----------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- --------xx---------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- --xxxx-------------------------------------------- -------------------------------------------------- -------------------------------------------------- --------------xxxx----xxxxxx---------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -xxxxxxxxxx-------------------------xx------------ -----------------KKRAREHRE--AP-------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ----------RAS-----------------------------------LL SF-QDE-EE-ET-------------------------------------- -----------------------------------------------E-- ------EVFKVKKSSYSKKIVKQLKKEYKE-------------------- --------------------------------DLEKSK------------ -------------------------------------------------- -------------------------------------------------- -VRTEVN-----------S------------------------------- ---------PTDVEPPLEKTGLTKDISQEDGTANSEQGEEEMEVES---- EKEEE--------------------------------------------- ---------KPKA-GGAFS------------------------------- ---------------------------SALSSLNVLRP-----------G EIPDAAFIHAARKKRQMARELGDFTP-VDSE-PGKSRLVR-ED--ENDA- SD-DEDDDEKRRIVFTVKEKSQRQKIAEE--I---GIEGSDDEALV-TGE QDEELSRWEQEQIRKGINIPQVQPSQPAEVxNLYYQNTYQTLSYGSSYGI PYTY--AAY-----------------------------GSS-ETKSQKTD NTVPFKTPSNEMTPVTIDLVKKQLKD-R---------------------- ------------------------------------------LDSMKELH KANRQQYEKHQQSREDSTKAIERLEGSSGGIGEQYKFLQEMRGYVQDLLE CFSEKVPLINELESAMHQLYKQRASRLVQRRQDDIKDESSEFSSHS---- ---------------NKALMAPNLDSFGRDRALYQEQVK-RRTAERE--- ---ARR-ARR-RQAREQTGKMADHLEGLSSDDEETSTDITNFNMER--DR ILKESSKVFEDVLESFYSIDCIKSQFEAWRSKYYASYKDAYIGLCLPKLF NPLIRLQLLIWTPLE----------------------------------- -GKCRDFETMLWFESLLFYGCEEQE--QEKDDADISLLPTIVERVVLPKL TVISENIWDPFSTT--------------QTSRMVAIVQKLVDGYPSVVNA ENKN-----TQMLLKALLLRMRRTLDDDVFMPLYPKNILENKNSGPYLFF QRQFWSSVKLLGNFLQWCGILSNKTLQELSIDGLLNRYILMAFQNSEYGD DSIKKAQSVIACFPKQWFTNLKGDKTISQLENFCRYLVHLADTIYRNSIG CSDVEKRNARENIKQIIKLLASIRALDHAVTVANDH-------------- --N------------VKELKILIEGK-- >ENSARWP00000020053 x------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ---------------------------------xxxxxxxxxxxxxxxxx xxxxxxxxxxxxxxxx---------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ---------xxx-------------------------------------- --------------------------------------xxxxxxx----- ----------------------------------------xx-------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ------xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx xxxxxx-------------------------------------------- -------------------------------------------------- -------------------------------------------------- --------------xxxx----xxxxxxxxxxxxxxxxxxxxxxxxxxxx xx------------------------------xxx--------------- -----------xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx---- -----xx------------------------------------------- xxxxx----------------------------------------xxxxx x------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ----------ET-------------------------------------- -----------------------------------------------E-- ------EVFKVKKSSYSKKIVKQLKKEYKE-------------------- --------------------------------DLEKSK------------ -------------------------------------------------- -------------------------------------------------- -VRTEVN-----------S------------------------------- ---------PTDVEPSLEKTGLTKDISQEDGTANSEQGEEEMEVES---- EKEEE--------------------------------------------- ---------KPKA-GGAFS------------------------------- ---------------------------SALSSLNVLRP-----------G EIPDAAFIHAARKKRQMARELGDFTP-VDSE-PGKSRLVR-ED--ENDA- SD-DEDDDEKRRIVFTVKEKSQRQKIAEE--I---GIEGSDDEALV-TGE QDEELSRWEQEQIRKGINIPQVQPSQPAEVxNLYYQNTYQTLSYGSSYGI PYTY--AAY-----------------------------GSS-ETKSQKTD NTVPFKTPSNEMTPVTIDLVKKQLKD-R---------------------- ------------------------------------------LDSMKELH KANRQQYEKHQQSREDSTKAIERLEGSSGGIGEQYKFLQEMRGYVQDLLE CFSEKVPLINELESAMHQLYKQRASRLVQRRQDDIKDESSEFSSHS---- ---------------NKALMAPNLDSFGRDRALYQEQVK-RRTAERE--- ---ARR-ARR-RQAREQTGKMADHLEGLSSDDEETSTDITNFNMER--DR ILKESSRVFEDVLESFYSIDCIKSQFEAWRSKYYASYKDAYIGLCLPKLF NPLIRLQLLIWTPLE----------------------------------- -GKCRDFETMLWFESLLFYGCEEQE--QEKDDADISLLPTIVERVVLPKL TVISENIWDPFSTT--------------QTSRMVAIVQKLVDGYPSVVNA ENKN-----TQMLLKALLLRMRRTLDDDVFMPLYPKNILENKNSGPYLFF QRQFWSSVKLLGNFLQWCGILSNKTLQELSIDGLLNRYILMAFQNSEYGD DSIKKAQSVIACFPKQWFTNLKGDKTISQLENFCRYLVHLADTIYRNSIG CSDVEKRNARENIKQIIKLLASIRALDHAVTVANDH-------------- --N------------VKELKILIEGK-- >ENSDNVP00000021478 -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ----------------------------------xxxxxxxxxxxxxxxx xxxxxxxxxx---------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- --------xx---------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ----xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx x------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ----------ET-------------------------------------- -----------------------------------------------E-- ------EVFKVKKSSYSKKIVKQLKKEYKE-------------------- --------------------------------DLEKSK------------ -------------------------------------------------- -------------------------------------------------- -VRTEVN-----------S------------------------------- ---------PTDVEPPLEKDIRIKDISQEDGTTNSEQGEEEMEVES---- EKEEE--------------------------------------------- ---------KPKA-GGAFS------------------------------- ---------------------------SALSSLNVLRP-----------G EIPDAAFIHAARKKRQMARELGDFTP-VDSE-PGKSRLVR-ED--ENDA- SD-DEDDDEKRRIVFTVKEKSQRQKIAEE--I---GIEGSDDEALV-TGE QDEELSRWEQEQIRKGINIPQVQPSQPAEVxNLYYQNTYQTLSYGSSYGI PYTY--AAY-----------------------------GSS-ETKSQKTD NTVPFKTPSNEMTPVTIDLVKKQLKD-R---------------------- ------------------------------------------LDSMKELH KANRQQYEKHQQSREDSTKAIERLEGSSGGIGEQYKFLQEMRGYVQDLLE CFSEKVPLINELESAMHQLYKQRASRLVQRRQDDIKDESSEFSSHS---- ---------------NKALMAPNLDSFGRDRALYQEQVK-RRTAERE--- ---ARR-ARR-RQAREQTGKMADHLEGLSSDDEETSTDITNFNMER--DR ILKESSKVFEDVLESFYSIDCIKSQFEAWRSKYFASYKDAYIGLCLPKLF NPLIRLQLLIWTPLE----------------------------------- -GKCRDFETMLWFESLLFYGCEEQE--QEKDDADILLLPTIVERVVLPKL TVISENIWDPFSTT--------------QTSRMVAIVQKLVDGYPSVVNA ENKN-----TQMLLKALLLRMRRTLDDDVFMPLYPKNILENKNSGPYLFF QRQFWSSVKLLGNFLQWCGILSNKTLQELSIDGLLNRYILMAFQNSEYGD DSIKKAQSVIACFPKQWFTNLKGDKTISQLENFCRYLVHLADTIYRNSIG CSDVEKRNARENIKQIIKLLASIRALDHAVTVANDH-------------- --N------------VKELKILIEGK-- >ENSAHAP00000027088 x------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ------------xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxXxxxxxxx xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx---------- -------------------------------------------------- --------xx---------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ------xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx xxxxx----------------------------------------xxxxx x------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ----------ET-------------------------------------- -----------------------------------------------E-- ------EVFKVKKSSYSKKIVKQLKKEYKE-------------------- --------------------------------DLEKSK------------ -------------------------------------------------- -------------------------------------------------- -VRTEVN-----------S------------------------------- ---------PTDVEPPLEKTGLTKDISQEDGTANSEQGEEEMEVES---- EKEEE--------------------------------------------- ---------KPKA-GGAFS------------------------------- ---------------------------SALSSLNVLRP-----------G EIPDAAFIHAARKKRQMARELGDFTP-VDSE-PGKSRLVR-ED--ENDA- SD-DEDDDEKRRIVFTVKEKSQRQKIAEE--I---GIEGSDDEALV-TGE QDEELSRWEQEQIRKGINIPQVQPSQPAEVxNLYYQNTYQTLSYGSSYGI PYTY--AAY-----------------------------GSS-ETKSQKTD NTVPFKTPSNEMTPVTIDLVKKQLKD-R---------------------- ------------------------------------------LDSMKELH KANRQQYEKHQQSREDSTKAIERLEGSSGGIGEQYKFLQEMRGYVQDLLE CFSEKVPLINELESAMHQLYKQRASRLVQRRQDDIKDESSEFSSHS---- ---------------NKALMAPNLDSFGRDRALYQEQVK-RRTAERE--- ---ARR-ARR-RQAREQTGKMADHLEGLSSDDEETSTDITNFNMER--DR ILKESSKVFEDVLESFYSIDCIKSQFEAWRSKYYASYKDAYIGLCLPKLF NPLIRLQLLIWTPLE----------------------------------- -GKCRDFETMLWFESLLFYGCEEQE--QEKDDADISLLPTIVERVVLPKL TVISENIWDPFSTT--------------QTSRMVAIVQKLVDGYPSVVNA ENKN-----TQMLLKALLLRMRRTLDDDVFMPLYPKNILENKNSGPYLFF QRQFWSSVKLLGNFLQWCGILSNKTLQELSIDGLLNRYILMAFQNSEYGD DSIKKAQSVIACFPKQWFTNLKGDKTISQLENFCRYLVHLADTIYRNSIG CSDVEKRNARENIKQIIKLLASIRALDHAVTVANDH-------------- --N------------VKELKILIEGK-- >ENSCPRP00005020794 x------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ----------------------xxxxxxxxxxxxxxxxxxxxxxxxxxxx xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx- -------------------------------------------------- -------------------------------------------------- ------------------------------------------------RK RNESEEED-------EER-------------------------------- -----------------------------------DEE------------ ------------------------------x------------------- -------------------------------------------------- ----------------------------------------------xxxx xxxxxxxxxxxxxxxxxxxxxxx--------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- --------------------------------xxxx-------------- -------------------------------------------------- -------------------------------------------------- --------------x----------------------------------- ----xxxxxxxxxxxx---------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------xxxxxxxxxxxxxxxxxxxxxxxxx------ --------xxx--------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ----xx-------------------------------------------- -------------------------------------------------- -------------------------------------------------- --------------xxxxxxxxxxxxxx---------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -xxxxxxxxxx-------------------------xx------------ -----------------KRRGRENKE--TA-------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ----------RGS-----------------------------------LL SF-RDE-EE-EA-------------------------------------- -----------------------------------------------E-- ------EVFKVKKSSYSKKIVKQLKKEYKE-------------------- --------------------------------DLEKSK------------ -------------------------------------------------- -------------------------------------------------- -VKTEVS-----------S------------------------------- ---------PSDAEPPIEKTGQIKDASQEDGTTNSEQGEEEMEVES---- EKEEE--------------------------------------------- ---------KPKA-GGAFS------------------------------- ---------------------------SALSSLNVLRP-----------G EIPDAAFIHAARKKRQMARELGDFTP-VDNE-PGKGRLVR-ED--ENDA- SD-DEDDDEKRRIVFSVKEKSQRQKIAEE--I---GIEGSDDEALV-TGE QDEELSRWEQEQIRKGINIPQVQASQPTEVxNLYYQNTYQTLSYGSSYGI PYTY--AAY-----------------------------GSS-ETKSQKTD NTVPFKTPSNEMTPVTIDLVKKQLKD-R---------------------- ------------------------------------------LDSMKDLH RANRQQYEKHQQSREDSAKAIERLEGSSGGIGERYKFLQEMRGYVQDLLE CFSEKVPLINELESSMHQLYKQRASRLVQRRQDDIKDESSEFSSHS---- ---------------SKALMAPNLDSFGRDRALYQEQVK-RRTAERE--- ---ARR-ARR-RQAREQTGKIADHLEGLSSDDEETSTDITNFNLER--DR ILKESSKVFEDVLESFYSIDCIKSQFEAWRSKYSSSYKDAYIGLCLPKLF NPLIRLQLLTWNPLE----------------------------------- -GKCRDFENMLWFESLLFYGCEEQE--QEKDDADISLLPTIVERVVLPKL TVIAENIWDPFSTS--------------QTSKMVAITQKLVDGYPSVVNA ENKN-----TQTFLKALLLRMRRTLDDDVFMPLYPKNVLENKNSGPYLFF QRQFWSSVKLLGNFLQWYGILSNKALQELSIDGLLNRYILMAFQNSEYGD DSIKKAQSVIACFPKQWFTNLKGDKTIIQLENFCRYLVHLADVIYRNSIG CSDVEKRNAREHIKQIIKLLASVRALDHAVTVANDH-------------- --N------------VKELKVLIEGK-- >ENSSMRP00000030034 -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ---MF--------------------------------------------- ----------------------------------------RKARRVNVRK RNESEDDD-------EER-------------------------------- -----------------------------------DED------------ ------------------------------xx------------------ -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------xxxxxxxxxxxxx xxxxxxxxxxxxxx------------------------------------ -------------------------------------------------- --------------x----------------------------------- ----xxxxxxxxxxxx---------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- --------xx---------------------------------------- -------------------------------------------xxxxxxx xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx--------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -----x-------------------------------------------- -------------------------------------------------- -------------------------------------------------- --------------xxx--------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -----------xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxLL SF-QDE-EE-ET-------------------------------------- -----------------------------------------------E-- ------EVFKVKKSSYSKKIVKLLKKEYKE-------------------- --------------------------------DLEKSK------------ -------------------------------------------------- -------------------------------------------------- -LKPETN-----------S------------------------------- ---------SADAEQCTEKTGQIKDAVQEDGAANSEQGEEEMEVES---- EKEED--------------------------------------------- ---------KPKA-ASAFS------------------------------- ---------------------------SALSSLNVLRP-----------G EIPDAAFIHAARKKRQMARELGDFLP-LDSD-PGKGRLIR-ED--ENDA- SD-DEDDDEKRRIVFSVKEKSQRQKIAEE--I---GIEGSDDEALI-AGE QDEELSRWEQEQIRKGINIPQVQATQPAEVxNLYYQSTYQTISYGSSYGI PYTY--AAY-----------------------------GSS-ETKSQKTD NTIPFKTPNNEMTPVTIDLVKKQLKD-R---------------------- ------------------------------------------LDSMKEFH KANQQQHEKHQQSRDDSTKTIERLEGSSGGVGERYKFLQEMRGYVQDLLE CFSEKVILINELESAMHQLYKQRASRLVQRRQDDIKDESSEFSSHS---- ---------------SKALMAPNLDSFGRDRTLYQEHVK-RRTAERE--- ---ARR-ARR-RLAREQSGKMADHLEGLSSDDEETSTDTTNFNMER--DR IMKESSKVFEDVLENFASIDCIKSQFETWRSKYFSSYKDAYIGLCLPRLL NPLIRLQLLTWNPLE----------------------------------- -DKCQDFESMLWFESLLFYGCEEYD--QEKDDADVSLLPTIVERVLLPKL TVLAESVWDPFSTT--------------QTSRMVAIIQKLINGYPSVVHA ENKN-----TQILLKALLLRMRRTLDDDVFMPLYPKSVLENKNSGPYLFF QRQFWSSVKLLGNFLQWYGILSNKTLQELAIDGLLNRYILMAFQNSEYGD DSIKKAQSVISCFPKQWFXNLKGNKTISHLENLCRYLVHLADTMYRNSIG SSDVEKRNTRENIKQIIKLLSSIRALDHAVAVANDH-------------- --N------------VKEMKVLSEGK-- >ENSPVIP00000010738 -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- --------E-ES-------------------------------------- -----------------------------------------------E-- ------EVFKVKKSSYSKKIVKLLKKEYKE-------------------- --------------------------------DLEKSKxx---------- ------xxxxxxxxxxxxxxxxxxxx------------------------ ------------------------------------------------xx xx------------------------------------------------ ----------------------------EDGATNSEQGEDEMEVES---- EKEEE--------------------------------------------- ---------KPKA-AGAFS------------------------------- ---------------------------SALSSLNVLRP-----------G EIPDAAFIHAARKKRQMARELGDFLP-LDSD-TGKGRLVR-ED--ENDA- SD-DEDDDEKRRIVFSVKEKSQRQKIAEE--I---GIEGSDDEALI-AGE QDEELSRWEQEQIRKGINIPQVQATQPAEVxNLYYQNTYQTMPYGSSYGI PYTY--AAY-----------------------------GAS-ETKSQKTD NTVPFKTPSNEMTPVTIDLVKKQLKD-R---------------------- ------------------------------------------LDTMKEFH KANQQQYEKHQQSRDDSTKAIERLEGSSGGVAERYKFLQEMRGYVQDLLE CFSEKVLLINELESAMHQLYKQRASRLVQRRQDDIKDESSEFSSHS---- ---------------NKALMAPNLDSFGRDRALYQEHVK-RRTAERE--- ---ARRxTRR-RLAREQSGKMADHLEGLSSDDEETSTDTTNFNMER--DR ILKESSKVFEDVLENFSSIDCIKTQFEAWRSKYLSSYKDAYIGLCLPKLL NPLIRLQLLTWNPLE----------------------------------- -EKCQDFESMLWFESLLFYGCEEYD--QEKDDADVSLLPTIVERVLLPKL TVLAENVWDPFSTT--------------QTSRMVAITQKLISGYPSVVHA ENKN-----TQTLLKALLLRMRRTLDDDVFMPLYPKSVLENKNSGPYLFF QRQFWSSVKLLGNFLQWYGILSNKTLQELAIDGLLNRYILMAFQNSEYGD DSIKKAQSVISSFPKQWFTNLKGNKTISHLENLCRYLVHLADTLYRNSIG SSDVEKRNAREHIKQIIKLLSSIRALDHAVTVANDH-------------- --N------------VKELKILSEGK-- >ENSACAP00000003129 -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ---MF--------------------------------------------- ----------------------------------------RKARRVNVRK RNESEE-------------------------------------------- -----------------------------------xxxxxxxxxxxxxxx xx-----xxxxxxxxxxxxxxxxxx----xxx------------------ -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------xx----------- -------xxxxxxx------------------------------------ -------------------------------------------------- --------------x----------------------------------- ----xxxxxxxxxxxx---------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- --------xx---------------------------------------- -------------------------------------------x------ -----------------------------------xxxxxx--------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -----x-------------------------------------------- -------------------------------------------------- -------------------------------------------------- --------------xx---------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------xxxxxLL SF-QDE-EE-ET-------------------------------------- -----------------------------------------------E-- ------EVFKVKKSSYSKKIVKLLKKEYKE-------------------- --------------------------------DLEKCK------------ -------------------------------------------------- -------------------------------------------------- -TRPETN-----------S------------------------------- ---------SVDVEQSADx-GQAKDAVQEDGVAISEQGEEEMEVES---- EKEEE--------------------------------------------- ---------KSKA-AGAFS------------------------------- ---------------------------SALSSLNVLRP-----------G EIPDAAFIHAARKKRQMARELGDFLP-LDND-PGKGRLIR-ED--DNDA- SD-DEDDDEKRRIVFSVKEKSQRQKIAEE--I---GIEGSDDDALI-AGE QDEELSRWEQEQIRKGINIPQVQASQPADMxNLYYQNIYQAMPYGSSYGI PYTY--AAY-----------------------------GSS-ETKAPKTD NTIPFKTSNNEMTPVTIDLVKKQLKD-R---------------------- ------------------------------------------LDSMKERH RSNQQQLENHQQSRDDSIKTIERLEGSSGGVGERYKFLQEMRGYVQDLLE CFSEKVILINELESSMHQLYKQRASRLVQRRQDDIKDESSEFSSHS---- ---------------SKALMAPNLDSFGRDRTLYQEHVK-RRTAERE--- ---ARSxARR-RLAREQSGKMADHLEGLSSDDEETSTDTTNFNMER--DR ILKESSKVFEDVLENFSSIDCIKSQFEAWRSKYLSTYKDAYIGLCLPKLL NPLIRLQLLTWNPLE----------------------------------- -GKCQDFESMLWFESLLFYGCEEND--QDKDDADVSLLPTIVERVLLPKL TVLAENVWDPFSTT--------------QTSRMVAITQKLVNGYPSVVHA ENKN-----TQTLLKGLLLRMRRTLDDDVFMPLYPKSVLENKNSGPYLFF QRQFWSSVKLLGNFLQWYGILSNKTLQELAIDGLLNRYILMAFQNSEYGD DSIKKAQSVISCFPKQWFTNLKGNKTISHLENLCRYLVHLADTIYRNSIG SSDVEKRNAREHIKQIIKLLSSIRALDHAVTVANEH-------------- --N------------VKELK--xEGK-- >ENSCPBP00000008146 x------------------------------------------------- -------------------------------------------------- -------------------------------------xxxxxxxxxxxxx xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx xxx----------------x------------------------------ -------------------------------------------------- -------------------------------------------------- -xGMF--------------------------------------------- ----------------------------------------RKARRVNVRK RNDSEEED-------EER-------------------------------- -----------------------------------Exxxx---------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------xx----------------------------------- -------------------------------------------xxxxxxx xxxxxxxx----xxx----------------------------------- ----xxxxxxxxxxxxxx-------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------xx-xxxx xxxxxxxxxxxxxxxxxx-------------------------------- --------x----------------------------------------- -------------------------------------------------- ----------------------------------------x--------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -----x-------------------------------------------- -------------------------------------------------- -------------------------------------------------- --------------xxx---------xx---------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -xxxxxxxxxx-------------------------xx------------ -----------------RKRLRENKExxxP-------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ----------RAS-----------------------------------LL SF-QDE-EE-EA-------------------------------------- -----------------------------------------------E-- ------EVFKVKKSSYSKKIVKLLKKEYKE-------------------- --------------------------------DLEKSK------------ -------------------------------------------------- -------------------------------------------------- -VKPEVN-----------S------------------------------- ---------PADAEQAIEKIGQVKDANQEDGTANSEQGEEEMEVES---- EKEEE--------------------------------------------- ---------KPKT-GGAFS------------------------------- ---------------------------SALSSLNVLRP-----------G EIPDAAFIHAARKKRQMARELGDFTP-IDNE-PGKGRLVR-ED--ENDA- SD-DEDDDEKRRIVFSVKEKSQRQKIAEE--I---GIEGSDDEALV-TGE QDEELSRWEQEQIRKGINIPQVQASQPTDVxNLYYHNSYQTMSYGSSYGI PYTY--AAY-----------------------------GSS-ETKSQKTD NILPFKTPSNEMTPVTIDLVKKQLTD-R---------------------- ------------------------------------------LDSMKELN KANQQQHEKHQQSREDSTKAIERLEGSSGGIGERYKFLQEMRGYVQDLLE CFSEKVPLINELESAMHQLYKQRASRLVQRRQDDIKDESSEFSSHS---- ---------------SKALMAPNLDSFGRDRALYQEYVK-RRTAERE--- ---ARRxTRR-RQAREQTGKMADHFEGLSSDDEETSTDITNFNMER--DR ILKESSKVFEDVLESFYSIDCIKSQFEAWRSKYFSSYKDAYIGLCLPKLF NPLIRLQLLTWTPLE----------------------------------- -GKCQDFESMLWFESLLFYGCEEQE--QEKDDADISLLPTIVERVVLPKL TVLAESIWDPFSTT--------------QTSRMVAVTQKLVNGYPSVVNA ENKN-----TQTLLKALLLRMRRTLDDDVFMPLYPKNILENKNSGPYLFF QRQFWSSVKLLGNFLQWYGILSNKTLQELSIDGLLNRYILMAFQNSEYGD DSIKKAQSVIACFPKQWFTNLKGDKTISQLENLCRYLVHLADTIYRNSIG CSDVEKRNAREHIKQTVKLLASIRALDHAVTVANEH-------------- --N------------VKELKVLIEGK-- >ENSCABP00000011410 -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ---MF--------------------------------------------- ----------------------------------------RKARRVNVRK RNDSEEED-------EER-------------------------------- -----------------------------------Exxxx---------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------x------------------------------------ ---------------------------------------------xxxxx xxxxxxxx----xxx----------------------------------- ----xxxxxxxxxxxxxx-------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------xxxxxxx xxxxxxxxxxxxxxxxx--------------------------------- -------------------------------------------------- -------------------------------------------------- ----------------------------------------x--------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -----x-------------------------------------------- -------------------------------------------------- -------------------------------------------------- --------------xxx---------xx---------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -xxxxxxxxxx-------------------------xx------------ -----------------RKRLRENKEx-xx-------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ----------RAS-----------------------------------LL SF-QDE-EE-EA-------------------------------------- -----------------------------------------------E-- ------EVFKVKKSSYSKKIVKLLKKEYKE-------------------- --------------------------------DLEKSK------------ -------------------------------------------------- -------------------------------------------------- -VKPEVN-----------S------------------------------- ---------PADAEQAIERTGQVKDANQEDGTANSEQGEEEMEVES---- EKEEE--------------------------------------------- ---------KPKT-GGAFS------------------------------- ---------------------------SALSSLNVLRP-----------G EIPDAAFIHAARKKRQMARELGDFTP-IDNE-PGKGRLVR-ED--ENDA- SD-DEDDDEKRRIVFSVKEKSQRQKIAEE--I---GIEGSDDEALV-TGE QDEELSRWEQEQIRKGINIPQVQASQPTEVxNLYYHNSYQTMSYGSSYGI PYTY--AAY-----------------------------GSS-ETKSQKTD NTLPFKTPSNEMTPVTIDLVKKQLKD-R---------------------- ------------------------------------------LDSMKELN KANQQQHEKHQQSREDSTKAIERLEGSSGGIGERYKFLQEMRGYVQDLLE CFSEKVPLINELESAMHQLYKQRASRLVQRRQDDIKDESSEFSSHS---- ---------------SKALMAPNLDSFGRDRALYQEHVK-RRTAERE--- ---ARR-ARR-RQAREQTGKMADHFEGLSSDDEETSTDITNFNMER--DR ILKESSKVFEDVLESFYSIDCIKSQFEAWRSKYFSSYKDAYIGLCLPKLF NPLVRLQLLTWTPLE----------------------------------- -GKSQDFESMLWFESLLFYGCEEQE--QEKDDVDISLLPTIVERVVLPKL TVLAESIWDPFSTT--------------QTSRMVAVTQKLVNGYPSVVNA ENKN-----TQTLLKALLLRMRRTLDDDVFMPLYPKNILENKNSGPYLFF QRQFWSSVKLLGNFLQWYGILSNKTLQELSIDGLLNRYILMAFQNSEYGD DSIKKAQSVIACFPKQWFTNLKGDKTISQLENLCRYLVHLADTIYRNSIG CSDVEKRNAREHIKQTVKLLASIRALDHAVTVANEH-------------- --N------------VKELKVLIEGK-- >ENSSPUP00000016250 -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ---MF--------------------------------------------- ----------------------------------------RKARRVNVRK RNESEEED-------EER-------------------------------- -----------------------------------DEE------------ -----------------------xxxxxxxxx------------------ -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------x------------------------------------ --------------------------xxxxxxxxxxxxxxxx-------- -------------xx----------------------------------- ----xxxxxxxxxxxxxxx------------------------------- ----------xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx xxxxxxxxxxxxxxxxxxxxxxxxx------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- --------xx---------------------------------------- -------------------------------------------------- -----------------------------xx-----xxxxx--------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -----x-------------------------------------------- -------------------------------------------------- -------------------------------------------------- --------------xx---------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------xxxxxLL SF-QDE-EE-EA-------------------------------------- -----------------------------------------------E-- ------EVFKVKKSSYSKKIVKLLKKEYKE-------------------- --------------------------------DLEKSK------------ -------------------------------------------------- -------------------------------------------------- -TKTEVN-----------S------------------------------- ---------AADADQPLDKTGQNKDAIQEDGAANSEQGEEEMEVES---- EKEEE--------------------------------------------- ---------KPKA-GGAFS------------------------------- ---------------------------NTLSSLNVLRP-----------G EIPDAAFIHAARKKRQMARELGDFTP-IDSE-PGKGRLIR-ED--ENDA- SD-DEDDDEKRRIVFSVKEKSQRQKIAEE--I---GIEGSDDEALG-TGE QDEELSRWEQEQIRKGINIPQVQASHPTEVxNLYYQNTYQTLSYGSSYGI PYTY--AAY-----------------------------GPS-ETKSLKTD NTIPFKTPSNEMTPVTIDLVKKQLKD-R---------------------- ------------------------------------------LESMKELH KANRQQHEKHQQSREDSSKAIERLEGSSGGVGERYKFLQEMRGYVQDLLE CFNEKVPLINELESAAHQLYKQRASRLVQRRQDDIKDESSEFSSHS---- ---------------SKALMAPNLDSFGRDRALYQEHVK-RRTAERE--- ---ARR-ARR-RQAREQTGKMADHLEGLSSDDEETSTDITNFNMEQ--DR ILKESSKVFEDVLESFYSIDCIKSQFEAWRSKYFSSYKDAYIGLCLPKLF NPLIRLQLLTWNPLE----------------------------------- -GKCRDFESMLWFESLLFYGCEEQE--QEKDDADISLLPTIVERVVLPKL TVIAENIWDPFSTT--------------QTSRMVAITQKLVNGYPSVVNA ENKN-----TQTFLKALLLRMRRTLDDDVFMPLYPKSVLENKNSGPYLFF QRQFWSSVKLLGNFLQWYGILSNKTLQELSIDGLLNRYILMAFQNSEYGD DSIKKAQSVIGCFPKHWFVNLKGDRTIPQLENFCRYLVHLADTVYRNSIG CSDVEKRNAREHIKQIIKLLASVRALDHAVTVANDH-------------- --N------------VKELKILIEGK-- >ENSXETP00000005279 -------------------------------------------------- -xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx--xx----xxxxx xxxxxxxxx----------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -SGMF--------------------------------------------- ----------------------------------------RKARRVNVRK RNDSEDEE-------REA-------------------------------- -----------------------------------D-------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- --------------------------xxx--------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ------------xxxxx--------------------------------- -------------------------------------------------- -------------------------------------------------- -----------------------------x-------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- --------xx---------------------------------------- ------------------------------------x------------- ----------------------------------------x--------- ---------------------------xxxxxxxxxxx------------ -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -----x-------------------------------------------- -------------------------------------------------- ---------------------------------------------xxxx- ---xxx--------xx---------------------------------- -------------------------------------------------- --------------------------------------------xxxxxx xxxxxxx------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -----------N-------------------------------------- -----------------------------------------------E-- ------EIFKVKKSNHSKKIVKMLKKEYKD-------------------- --------------------------------DLEKTKxxxxxxxxxxxx xxxxxxxxx----------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------GEEEMEVES---- EKEEE--------------------------------------------- ---------Kxxx--GSFT------------------------------- ---------------------------NAVSSLNVLRP-----------G EIPDAAFIHAARKKRQMARELGDxxx-VDGExxxxSRLVR-ED--ENDA- SD-DEDDD-xRRIVFSVREKSQRQKIAEE--I---GIEGSDDEALA-TGD QDEELSRWEQEQIRKGISIPQVQAPQPPET-NMFYPSTYQGMPYGTSYGV PYTY--AAY-----------------------------GST-ETKSQKPD NSVSFKTPSNEMTPVTIDLVKKQLKD-R---------------------- ------------------------------------------LDAMKEVH KANLEQYEKHVQSREDSTSSISRLEGCSGSNAERYQFLQEMRGYVQDLLE CFREKVPLINELESAMHQLYKQRAARLVQRRQDDIKDESSEFSSHS---- ---------------SKAVMAPNLDPFGRDRALFQEHAKQRRIAERE--- ---ARR-TRR-RQAREVPGKTAEHLEGLSSDDEETSTDITNFNMEK--DR ILKEAGKVFEDTLENFHSIEYIKDQFESWRSTYYSTYKDAYIGLCLPKLL NPLVRIQLLTWNPLE----------------------------------- -ANCCNFESMMWFECLLFYGCEEKE--YDKEDVDIVLLPSLVEKVILPKL AGIAENVWDPFSTT--------------QTNRLAAVVQKLVNGYPTVLNS ENKN-----TEALLKALLARMRRTLDDDVFMPLYPKNVIENKNSAPCIFF QRQFWSSVKLLGNFLKWHGVLSNKALQELSVDGLLNRYILMAFQNNENGE DSIKKAQSVITCFPRQWFANLKGGKTIPQLENFARYLTHLAGTIYRNNVG CSDIERRNAREQIRQIVKLLASIRALESAMSVANDY-------------- --N------------VKDIKAPTEGK-- >ENSLACP00000009286 -------------------xx----------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -----x-------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- --------xxx-------------------------xx------------ -----------------KKKNKESKE--LP-------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ----------KAS-----------------------------------LL SF-QDE-EE-ET-------------------------------------- -----------------------------------------------E-- ------EVFKVKKSSYSKKIVKQLKKEYKE-------------------- --------------------------------DLEKNK------------ -------------------------------------------------- -------------------------------------------------- -VKPDGN-----------Sx--------------------------xxxx xxxxxxxxxx-----------------xEDPAGNSEQGEEEMEVDSxxxx xxxxD--------------------------------------------- ---------KTKS-TGAFA------------------------------- ---------------------------NAISSLSTLRP-----------G EIPDAAFIHAARKRRQMARELGDGSS-TDLE-MSKGRLVR-ED--ENDA- SD---DDDEKRRIVFSVKEKSQRQKIAEE--IVRxGIEGSDDEALA-TGH QDEELNRWEQEQIRKGISIPQVQTSPPMEMNNMYYQNTYQAMPYGSSYGV PYTY--AAY-----------------------------GAT-EAKPLKAE TTVPFKATDNEMTPVTIDLVKKRLKE-Rxxxxxxxxxxxxxxxxxxxxxx xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx------- -------------------------------------------------- ----QVPLINELESAMYQLLKQRAARLVQRRQDDIKDESSEYSSHS---- ---------------SKALVAPNLDTFGRDRSHYQEHAKVRRIAERE--- ---ARR-TRR-RQAREQTGKMAEHHEGISSDDEETSTDITNFNMEQ--DR ILKESKKVFEDVLEDFYSIDCIKFRFEAWRKMYLTCYQDAYIGLCLSKLF NPLIRLQLITWNPLE----------------------------------- -VKCSDFENMMWFESLLFYGCExxxx-QQKDDVDVALLPAIIEKVIVAKL TGLAEHIWDPLSTS--------------QTSRFITFLLKLIQGYPSVVNA ENRS-----TQALLKAIVLRIRKSLDDDVFIPLYPKNVLENKNSGPYLFF QRQFWSSVKLMNNILQWHGILSNRTLLELAVDSLLNRYILLALQISEPGE DSIKKSQSVILCFPKQWFTSLKGEKTIPHLENFCRYLVHLANAIYRISVG CSDVEKRNARDQIKQVIKCLASIHALDHAVALANEY-------------- --S------------VKDIKALIEGK-- >ENSGMOP00000001987 -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ---MF--------------------------------------------- ----------------------------------------KKAKRANLRR RNDSDEDE-------x---------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------xx----------------------------------- ----------------------------------------xx-------- ------xxxx---------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ----------------------------------x--------------- ----------------------------------------x--------- ---------------------xxxxx------------------------ -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -----x-------------------------------------------- -----------------------xxx------------------------ -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ---------------------------------------------xx--- -------------------------------------------------- -----------------------------------xxxxxxxxxxxxxxx xxxxxxxxxxxxxxxxxxxxxxxxxxxxxx-------------------- -------xxxKAS-----------------------------------LL SF-DDD--E-EG-------------------------------------- -----------------------------------------------S-- ------EVFRVKKSNYSKKIVKQLKKEYKE-------------------- --------------------------------DLEKTG------------ -----------------------xxxxxxxx------------------- -----------------xxx------------------------------ -------------------------------------------------- -------------------------------------------------- -----------xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx x------------------------------------------------- ------------------------xxxNTLSSLSSLRP-----------G EIPDAAFIHAARKRRQLARELGGEPPLVETD-APKKRLTR-Exxxxxxx- xx-xxx--xKRINFSGVKNKSQRQKIAEE--I---GIEGSDDEALD-T-x HDEELSRWEQEQIRKGISIPQVQSNPPEDN-TAYYQNSYETQPYGASYNM PYTY--STVxx------------------xxxxxxxxxx----------- -PVPYSGPAAELAPVSSDLVKKRLRD-R---------------------- ------------------------------------------LGQMRTGH EANAKRYDQIVDELTASDSAIHRLEGSSNDNAEQYKFLQEMRGYVGDLLE CFGEKVPTILELESAMHQLLRQRAARLVQRRQDDIKDESAEFASLS---- ---------------SKAVMAPSLDSFGRDRTAYQEHARQRRIAERE--- ---ARR-TRR-RQAREQDGKRAEHREGLSSDDEETSTDITSFDTER--DR IVRECKKVFEDAVEDFHSLDFIKARFEVWRRDYVQCYREAYIGLCLPKLF NPLVRLQLITWSPLQ----------------------------------- -AECANFEYMLWFESLLFYGCEEQGx-LRAGDVDVNLLPAIVEKVLISKL SVLAEQVWDPLSSS--------------QTARLVGFIRRLTRSYPTVLHG DNRY-----TEELLKAVLLRTRRSLDEDVFLPLYPKNVLENKNGGPYLFY ERQFWSCVKLLGNILQFEGILSSSCVRELALDSTLNRYILSALQTTDSTD DSVLKCQQLVQCFPAQWFTGMTGQKTLPQLEPLCRYLTHVASTLYRGSLA ASDLERRSLKDQIKEVVKMLGQMNALDHIITVATEH-------------- --G------------IKDIKPLLEAK-x >ENSPLAP00000026770 -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ---MF--------------------------------------------- ----------------------------------------KRAKRVNLRR RNDSDEEE-------LEE-------------------------------- -------------------------------------------------- -------xx----------------------------------------- -------------------------------------------------- -----------xxx------------------------------------ -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ------------xxx----------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------xxxx--------------- ----------------------------------------x--------- ---------------------xx-xx------------------------ -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -----x-------------------------------------------- -----------------------xxx------------------------ -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ------------xxxxxxxxxxx--------------------------- ------xxxxxxxxxxxxxxxxxxxxxxxxx------------------- ----------------------------------------------xxxx --------xxKAS-----------------------------------LL SF-DDx--E-EG-------------------------------------- -----------------------------------------------S-- ------EVFRVKKPNHSKKIVKQLKKEYKE-------------------- --------------------------------DLQKSG------------ -----------------------xxxxxxxx------------------- -----------------xxxxxxxxxxxxxxx------------------ ------------------xxxx---------------------------- ----------------------------------SEHGEEEMEVES---- GDEQDxxxx----------------------------------------- --------------------xQE--------------------------- --------------xQLSxxxxxxxxxNTLSSLTSLKP-----------G EIPDAAFIHAARKRRQLARELGGEAPLVEAE-PSKKRMTQ-Ex---RDC- SD-DEDEDEKRIRFSGVKNKSQRQKIAEE--I---GIEGSDDEALD-T-x QDEEVSRWEQEQIRKGISIPQVQSSQPEDS-TAYYQNSYETQPYGSSYSM PFTY--SSVxxxxxxxxxxxxxxxxxxx-x-------------------- -------PICDLTPVSIDLVKKRLQD-R---------------------- ------------------------------------------LDQMHAGH NANIKRYEQIRDELEASESTIQQLEGSSNDNADRYKFLQEMRGYVGDLLE CFSEKVPAVLELEAAMHQLLRQRAARLVQRRQDDIKDESSEFASLS---- ---------------NKAVMAPSLDSFGRDRAAYQENSRQRRIAERE--- ---ARR-TRR-RQAREQNGKRAEHKEGLSSDDEETSTDITSFNMER--DR IKAESRKVFEDVVEDFHSLDCIKSRFEVWKREYPDCYRDAYIGLCLPKLF NPLVRLQLITWNPLE----------------------------------- -EPCANFEYMLWFESLLFYGFEEHRx-LEKDDGDIGLLPAIVEKVLLSKL SVLAEQVWDPLSSS--------------QTTRLVSFIHRLAEGYPTVLHG DNQY-----TQELLKSIVLRTRRTLDEDVFLPLYPKNVMDNKNSGAYLFY QRQFWSCVKLLGNIIQWDGILSYSCLKDLALDSTLNRYILSALQSTDIGE ENVHKCQKVMECLPAQWFSGLKGQHTLPQLEPLCRYLTHLANTLHRSSVG ASDTERRTTREQVREVVRMLGRVNALDHIIAVAEEH-------------- --G------------VKDIKQLMEVK-- >ENSPMEP00000005879 -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ---MF--------------------------------------------- ----------------------------------------KRAKRANLRR RNDSDEDE-------LEE-------------------------------- -------------------------------------------------- -------xx----------------------------------------- -------------------------------------------------- -----------xxx------------------------------------ -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ------------xxx----------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------xxxx--------------- ----------------------------------------x--------- ---------------------xx-xx------------------------ -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -----x-------------------------------------------- -----------------------xxx------------------------ -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ------------xxxxxxxxxxx--------------------------- ------xxxxxxxxxxxxxxxxxxxxxxxxx------------------- ----------------------------------------------xxxx --------xxKAS-----------------------------------LL SF-DDx--E-EG-------------------------------------- -----------------------------------------------S-- ------EVFRVKKPNHSKKIVKQLKKEYKE-------------------- --------------------------------DLQKSG------------ -----------------------xxxxxxxx------------------- -----------------xxxxxxxxxxxxxxx------------------ ------------------xxxx---------------------------- ----------------------------------SEHGEEEMEVES---- GDEQNxxxx----------------------------------------- --------------------xQE--------------------------- --------------xQLSxxxxxxxxxNTLSSLTSLKP-----------G EIPDAAFIHAARKRRQLARELGGEAPLVEAE-PSKKRMTQ-Ex---RDC- SD-DEDEDEKRIRFSGVKNKSQRQKIAEE--I---GIEGSDDEALD-T-x QDEEVSRWEQEQIRKGISIPQVQSSQPEDS-TAYYQNSYETQPYGSSYSM PFTY--SSVxxxxxxxxxxxxxxxxxxx-x-------------------- -------PICDLTPVSIDLVKKRLQD-R---------------------- ------------------------------------------LDQMHAGH NANIKRYEQIRDELEASESTIQQLEGSSNDNADRYKFLQEMRGYVGDLLE CFSEKVPAVLELEAAMHQLLRQRAARLVQRRQDDIKDESSEFASLS---- ---------------NKAVMAPSLDSFGRDRAAYQENSRQRRIAERE--- ---ARR-TRR-RQAREQNGKRAEHKEGLSSDDEETSTDITSFNMER--DR IKAESKKVFEDVVEDFHSLDCIKSRFEVWKREYPDCYRDAYIGLCLPKLF NPLVRLQLITWNPLE----------------------------------- -EGCANFEYMLWFESLLFYGFEEHRx-LEKDDGDIGLLPAIVEKVLLSKL SVLAEQVWDPLSSS--------------QTTRLVSFIHRLAEGYPTVLHG DNQY-----TQELLKSIVLRTRRTLDEDVFLPLYPKNVMDNKNSGAYLFY QRQFWSCVKLLGNIIQWDGILSYSCLKDLALDSTLNRYILSALQSTDIGE ENVHKCQKVMECLPAQWFSGLKGQHTLPQLEPLCRYLTHLANTLHRSSVG ASDTERRTTREQVREVVRMLGRVNALDHIIAVAEEH-------------- --G------------VKDIKQLMEVK-- >ENSPFOP00000018044 -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ---MF--------------------------------------------- ----------------------------------------KRAKRANLRR RNDSDEDE-------LEE-------------------------------- -------------------------------------------------- -------xx----------------------------------------- -------------------------------------------------- -----------xxx------------------------------------ -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ------------xxx----------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------xxxx--------------- ----------------------------------------x--------- ---------------------xx-xx------------------------ -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -----x-------------------------------------------- -----------------------xxx------------------------ -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ------------xxxxxxxxxxx--------------------------- ------xxxxxxxxxxxxxxxxxxxxxxxxx------------------- ----------------------------------------------xxxx --------xxKAS-----------------------------------LL SF-DDx--E-EG-------------------------------------- -----------------------------------------------S-- ------EVFRVKKPNHSKKIVKQLKKEYKE-------------------- --------------------------------DLQKSG------------ -----------------------xxxxxxxx------------------- -----------------xxxxxxxxxxxxxxx------------------ ------------------xxxx---------------------------- ----------------------------------SEHGEEEMEVES---- GDEQNxxxx----------------------------------------- --------------------xQE--------------------------- --------------xQLSxxxxxxxxxNTLSSLTSLKP-----------G EIPDAAFIHAARKRRQLARELGGEAPLVEAE-PSKKRMTQ-Ex---RDC- SD-DEDEDEKRIRFSGVKNKSQRQKIAEE--I---GIEGSDDEALD-T-x QDEEVSRWEQEQIRKGISIPQVQSSQPEDS-TAYYQNSYETQPYGSSYSM PFTY--SSVxxxxxxxxxxxxxxxxxxx-x-------------------- -------PICDLTPVSIDLVKKRLQD-R---------------------- ------------------------------------------LDQMHAGH NANIKRYEQIRDELEASESTIQQLEGSSNDNADRYKFLQEMRGYVGDLLE CFSEKVPAVLELEAAMHQLLRQRAARLVQRRQDDIKDESSEFASLS---- ---------------NKAVMAPSLDSFGRDRAAYQENSRQRRIAERE--- ---ARR-TRR-RQAREQNGKRAEHKEGLSSDDEETSTDITSFNMER--DR IKAESKKVFEDVVEDFHSLDCIKSRFEVWKREYPDCYRDAYIGLCLPKLF NPLVRLQLITWNPLE----------------------------------- -EPCANFEYMLWFESLLFYGFEEHRx-LEKDDGDIGLLPAIVEKVLLSKL SVLAEQVWDPLSSS--------------QTTRLVSFIHRLAEGYPTVLHG DNQY-----TQELLKSIVLRTRRTLDEDVFLPLYPKNVMDNKNSGAYLFY QRQFWSCVKLLGNIIQWDGILSYSCLKDLALDSTLNRYILSALQSTDIGE ENVHKCQKVMECLPAQWFSGLKGQHTLPQLEPLCRYLTHLANTLHRSSVG ASDTERRTTREQVREVVRMLGRVNALDHIIAVAEEH-------------- --G------------VKDIKQLMEVK-- >ENSPREP00000021954 -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ---MF--------------------------------------------- ----------------------------------------KRAKRANLRR RNDSDEDE-------LEE-------------------------------- -------------------------------------------------- -------xx----------------------------------------- -------------------------------------------------- -----------xxx------------------------------------ -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ------------xxx----------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------xxxx--------------- ----------------------------------------x--------- ---------------------xx-xx------------------------ -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -----x-------------------------------------------- -----------------------xxx------------------------ -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ------------xxxxxxxxxxx--------------------------- ------xxxxxxxxxxxxxxxxxxxxxxxxx------------------- ----------------------------------------------xxxx --------xxKAS-----------------------------------LL SF-DDx--E-EG-------------------------------------- -----------------------------------------------S-- ------EVFRVKKPNHSKKIVKQLKKEYKE-------------------- --------------------------------DLQKSG------------ -----------------------xxxxxxxx------------------- -----------------xxxxxxxxxxxxxxx------------------ ------------------xxxx---------------------------- ----------------------------------SEHGEEEMEVES---- GDEQNxxxx----------------------------------------- --------------------xQG--------------------------- --------------xQLSxxxxxxxxxNTLSSLTSLKP-----------G EIPDAAFIHAARKRRQLARELGGEAPLVEAE-PSTKRMTQ-Ex---RDC- SD-DEDEDEKRIRFSGVKNKSQRQKIAEE--I---GIEGSDDEALD-T-x QDEEVSRWEQEQIRKGISIPQVQSSQPEDN-TAYYQNSYETQPYGSSYSM PFTY--SSVxxxxxxxxxxxxxxxxxxx-x-------------------- -------PICDLTPVSIDLVKKRLQD-R---------------------- ------------------------------------------LAQMHAGH NANIKRYEQIRDELEASESTILQLEGSSNDNADRYKFLQEMRGYVGDLLE CFSEKVPAVLELEAAMHQLLRQRAARLVQRRQDDIKDESSEFASLS---- ---------------NKAVMAPSLDSFGRDRAAYQENSRQRRIAERE--- ---ARR-TRR-RQAREQNGKRAEHKEGLSSDDEETSTDITSFNMER--DR IKGESKKIFEDAVEDFHSLDCIKSHFEVWRREYPDCYRDAYIGLCLPKLF NPLVRMQLITWNPLE----------------------------------- -EPCANFEYMLWFESLLFYGFEEHRx-LEKDDGDIGLLPAIVEKVLLSKL SVLAEQVWDPLSSS--------------QTTRLVSFIHRLAEGYPTVLHG DNQY-----TQELLKTIVLRTRRTLDEDVFLPLYPKNVMDNKNSSAYLFY QRQFWSCVKLLGNIIQWDGILSYSCLKDLALDSTLNRYILSALQSTDVGE ENVQKCQKVMECLPAQWFSGLKGQHTLPQLEPLCRYLTHLANTLHRSSVG ASDNERRTTREQVREVVRMLGRVNALDHIIAVAEEH-------------- --G------------VKDIKQLMEVK-- >ENSGAFP00000026355 -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ---MF--------------------------------------------- ----------------------------------------KRAKRVNLRR RNDSDEDE-------QEE-------------------------------- -------------------------------------------------- -------xx----------------------------------------- -------------------------------------------------- -----------xxx------------------------------------ -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ------------xxx----------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------xxxx--------------- ----------------------------------------x--------- ---------------------xx-xx------------------------ -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -----x-------------------------------------------- -----------------------xxx------------------------ -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ------------xxxxxxxxxxx--------------------------- ------xxxxxxxxxxxxxxxxxxxxxxxxx------------------- ----------------------------------------------xxxx --------xxKAS-----------------------------------LL SF-DDx--E-EG-------------------------------------- -----------------------------------------------S-- ------EVFRVKKPNHSKKIVKQLKKEYKE-------------------- --------------------------------DLQKSG------------ -----------------------xxxxxxxx------------------- -----------------xxxxxxxxxxxxxxx------------------ ------------------xxxx---------------------------- ----------------------------------SEQGEEAMEVES---- GDEQDxxxx----------------------------------------- --------------------xQG--------------------------- --------------xQLSxxxxxxxxxNTLSSLTSLKP-----------G EIPDAAFIHAARKRRQLARELGGEAPLVEAE-PSKKRMTQ-Ex---RDC- SD-DEDEDEKRIRFSGVKNKSQRQKIAEE--I---GIEGSDDEALD-T-x QDEEVSRWEQEQIRKGISIPQVQSSQPEDS-TAYYQNSYETQPYGSSYSL PFTY--SSVxxxxxxxxxxxxxxxxxxx-x-------------------- -------PICDLTPVSIDLVKKRLQD-R---------------------- ------------------------------------------LAQMHAGH NANVKRYEQIRDELEASESTIQQLEGSSNDNADRYKFLQEMRGYVGDLLE CFSEKVPAVLELEAAMHQLLRQRAARLVQRRQDDIKDESSEFASLS---- ---------------NKAVMAPSLDSFGRDRAAYQENSRQRRIAERE--- ---ARR-TRR-RQAREQNGKRAEHKEGLSSDDEETSTDITSFNMER--DR IKADSKKVFEDVVEDFHSLDCIKSRFEVWRREYPDCYRDAYIGLCLPKLF NPLVRLQLITWNPLE----------------------------------- -EPCANFEYMLWFESLLFYGFEEHRx-LEKDDGDIGLLPAIVEKVLLSKL SVLAEQVWDPLSSS--------------QTTRLVSFIHRLAEGYPTVLHG DNQY-----TQELLKAIVLRTRRTLDEDAFLPLYPKTVMDNKNSGAYLFY QRQFWSCVKLLGNIIQWDGVLSYSCLKDLALDSTLNRYILSALQSTDVGE ENVQKCQKVVECLPAQWFSGLKGQHTLPQLEPLCRYLTHLANTLHRSSVG ASDTERRTTREQVREVVRMLGRVNALDHIIAVAEEH-------------- --G------------VKDIKQLMEVK-- >ENSXCOP00000024043 -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ---MF--------------------------------------------- ----------------------------------------KRAKRANLRR RNDSDEDE-------QEE-------------------------------- -------------------------------------------------- -------xx----------------------------------------- -------------------------------------------------- -----------xxx------------------------------------ -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ------------xxx----------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------xxxx--------------- ----------------------------------------x--------- ---------------------xx-xx------------------------ -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -----x-------------------------------------------- -----------------------xxx------------------------ -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ------------xxxxxxxxxxx--------------------------- ------xxxxxxxxxxxxxxxxxxxxxxxxx------------------- ----------------------------------------------xxxx --------xxKAS-----------------------------------LL SF-DDx--E-EG-------------------------------------- -----------------------------------------------S-- ------EVFRVKKPNHSKKIVKQLKKEYKE-------------------- --------------------------------DLQKSx------------ -----------------------x-------------------------- ----------------------xxxxxxxxxx------------------ ------------------xxxx---------------------------- ----------------------------------SEQGEEEMEVES---- GDEQDxxxx----------------------------------------- --------------------xQG--------------------------- --------------xQLSxxxxxxxxxNTLSSLTSLKP-----------G EIPDAAFIHAARKRRQLARELGGEAPLVEAE-PSKKRMAQ-Ex---RDC- SD-DEDEDEKRIRFSGVKNKSQRQKIAEE--I---GIEGSDDEALD-T-x QDEEVSRWEQEQIRKGISIPQVQSSQPEDS-TAYYQNSYETQPYGSSYSM PFTY--SSVxxxxxxxxxxxxxxxxxxx-x-------------------- -------PICDLTPVSIDLVKERMQD-R---------------------- ------------------------------------------LAQMHAGH NANIKRYEQISDELEASESTIQQLEGSSNDNADRYKFLQEMRGYVGDLLE CFSEKVPAVLELEAAMHQLLRQRAARLVQRRQDDIKDESSEFASLS---- ---------------NKAVMAPSLDSFGRDRAAYQENSRQRRIAERE--- ---ARR-TRR-RQAREQNGKRAEHKEGLSSDDEETSTDITSFNMER--DR IKADSKKVFEDVVEDFHSLDCIKSHFEVWRREYPDCYRDAYIGLCLPKLF NPLVRLQLITWNPLE----------------------------------- -EPCANFEYMLWFESLLFYGFEEHRx-LEKDDGDIGLLPAIVEKVLLSKL SVLAEQVWDPLSSS--------------QTTRLVSFIHRLAEGYPTVLHG DNQY-----TQELLKTIVLRTRRTLDEDVFLPLYPKNVMDNKNSSAYLFY ERQFWSCVKLLGNIIQWDGILSYSCLKDLALDSTLNRYILSALQSTDVGE ENVQKCQKVVECLPAQWFSGMKGQHTLPQLEPLCRYLTHLANTLHRSSVG APDTERRT---QVREVVRMLGRVNALDHIIAVAEEH-------------- --G------------VKDIKQLMEVK-- >ENSXMAP00000016088 -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ---MF--------------------------------------------- ----------------------------------------KRAKRANLRR RNDSDEDE-------QEE-------------------------------- -------------------------------------------------- -------xx----------------------------------------- -------------------------------------------------- -----------xxx------------------------------------ -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ------------xxx----------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------xxxx--------------- ----------------------------------------x--------- ---------------------xx-xx------------------------ -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -----x-------------------------------------------- -----------------------xxx------------------------ -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ------------xxxxxxxxxxx--------------------------- ------xxxxxxxxxxxxxxxxxxxxxxxxx------------------- ----------------------------------------------xxxx --------xxKAS-----------------------------------LL SF-DDx--E-EG-------------------------------------- -----------------------------------------------S-- ------EVFRVKKPNHSKKIVKQLKKEYKE-------------------- --------------------------------DLQKSx------------ -----------------------x-------------------------- ----------------------xxxxxxxxxx------------------ ------------------xxxx---------------------------- ----------------------------------SEQGEEEMEVES---- GDEQDxxxx----------------------------------------- --------------------xQG--------------------------- --------------xQLSxxxxxxxxxNTLSSLTSLKP-----------G EIPDAAFIHAARKRRQLARELGGEAPLVEAE-PSKKRMAQ-Ex---RDC- SD-DEDEDEKRIRFSGVKNKSQRQKIAEE--I---GIEGSDDEALD-T-x QDEEVSRWEQEQIRKGISIPQVQSSQPEDS-TAYYQNSYETQPYGSSYSM PFTY--SSVxxxxxxxxxxxxxxxxxxx-x-------------------- -------PICDLTPVSIDLVKKRLQD-R---------------------- ------------------------------------------LAQMHAGH NANIKRYEQISDELEASESTIQQLEGSSNDNADRYKFLQEMRGYVGDLLE CFSEKVPAVLELEAAMHQLLRQRAARLVQRRQDDIKDESSEFASLS---- ---------------NKAVMAPSLDSFGRDRAAYQENSRQRRIAERE--- ---ARR-TRR-RQAREQNGKRAEHKEGLSSDDEETSTDITSFNMER--DR IKADSKKVFEDVVEDFHSLDCIKSHFEVWRREYPDCYRDAYIGLCLPKLF NPLVRLQLITWNPLE----------------------------------- -EPCANFEYMLWFESLLFYGFEEHRx-LEKDDGDIGLLPAIVEKVLLSKL SVLAEQVWDPLSSS--------------QTTRLVSFIHRLAEGYPTVLHG DNQY-----TQELLKTIVLRTRRTLDEDVFLPLYPKTVMDNKNSSAYLFY ERQFWSCVKLLGNIIQWDGILSYSCLKDLALDSTLNRYILSALQSTDVGE ENVQKCQKVVECLPAQWFSGMKGQHTLPQLEPLCRYLTHLANTLHRSSVG APDTERRTAREQVREVVRMLGRVNALDHIIAVAEEH-------------- --G------------VKDIKQLMEVK-- >ENSFHEP00000032161 -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ---MF--------------------------------------------- ----------------------------------------KKAKRVNLRR RNDSDEDE-------LEA-------------------------------- -------------------------------------------------- -------xx----------------------------------------- -------------------------------------------------- -----------xxx------------------------------------ -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ------------xxx----------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------xxxx--------------- ----------------------------------------x--------- ---------------------xx-xx------------------------ -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -----x-------------------------------------------- -----------------------xxx------------------------ -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ------------xxxxxxxxxxx--------------------------- ------xxxxxxxxxxxxxxxxxxxxxxxxx------------------- ----------------------------------------------xxxx --------xxKAS-----------------------------------LL SFxxxx--E-EG-------------------------------------- -----------------------------------------------S-- ------EVFRVKKPNHSKKIVKQLKKEYKE-------------------- --------------------------------DLQKTx------------ -----------------------x-------------------------- ------------------xxxxxxxxxxxxxx------------------ ------------------xxxx---------------------------- ----------------------------------SEHGEEEMEVES---- ADEQDxxxx----------------------------------------- --------------------xQG--------------------------- --------------xQLSxxxxxxxxxNTLSSLTSLKP-----------G EIPDAAFIHAARKRRQLARELGGEAPLVEPE-PSKKHLTR-Dx---RDG- SD-DEDEDEKRIRFSGVKNKSQRQKIAEE--I---GIEGSDDEALD-T-x QDEEVSRWEQEQIRKGISIPQVQSSQPEDS-TVYYQNSYETQPYGSSYSM PFTY--STVxxxxxxxxxxxxxxxxxxx-x-------------------- -------PICDLTPVSIDLVKKRLQD-R---------------------- ------------------------------------------LVQMHAGH NANITRYEQIRDDLAASESAIQQLEGSSNDNADRYKFLQEMRGYVGDLLE CFSEKVPAVLELEAAMHQLLRQRAARLAQRRQDDIKDESSEFASLS---- ---------------NKAVMAPSLDSFGRDRAAYQEHSRQRRIAERE--- ---ARR-TRR-RQAREQNGKRAEHKEGLSSDDEETSTDVTTFNMER--DR IRAESKKVFEDVVEDFHSLDCIKTRFEAWRKEYPDCYRDAYIGLCLPKLF NPLVRLQLITWNPLE----------------------------------- -EPCANFEYMLWFESLLFYGFEENKx-LHKEDGDIGLLPAIVEKVLLSKL SVLAEQVWDPLSSS--------------QTARLVSFIHRLAEGYPTVLHG DNLY-----TQELLKTIVLRTRRTLDEDVFLPLYPKNVMDNKNSGAYLFY QRQFWSCIKLLGNIVQWDGILSYSCLKDLALDSTLNRYILSALQSTDIGE ENVQKCQKVVECLPPQWFSGLKGQQTLPQLEPLCRYLTHLANTLHRSTVG ASDVERRTAKEQIREVVKMLGRVNALDHIIAVAEEH-------------- --G------------VKDIKQLLEVK-- >ENSOMEP00000031332 -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ---MF--------------------------------------------- ----------------------------------------KRAKRANFRR RNDSEEDE-------QEP-------------------------------- -------------------------------------------------- -------xx----------------------------------------- -------------------------------------------------- -----------xxx------------------------------------ -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ------------xxx----------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------xxxx--------------- ----------------------------------------x--------- ---------------------xx-xx------------------------ -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -----x-------------------------------------------- -----------------------xxx------------------------ -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- --------xxxx-------xxx---------------------------- -------------------------------------------------- --xxxxxxxxxx-------------------------------------- -------xxxxxxxxxxxxxxxxxxxxxxxx------------------- ----------------------------------------------xxxx --------xxKVS-----------------------------------LL SF-DEE--E-EA-------------------------------------- -----------------------------------------------T-- ------EVFRVKKPNHSKKIVKQLKKEYKE-------------------- --------------------------------DLERSG------------ -----------------------xxxxxxxx------------------- -----------------xxxxxxxxxxxxxxx------------------ ------------------xxxx---------------------------- ----------------------------------SEHGEEEMEVDS---- -x------------------------------------------------ -------------------------------------------------- --xxxxxxxxxxxxAQMSxxxxxxxxxNTLSSLSSLKP-----------G EIPDAAFIHAARKRRQLARELGGDAPLVQMD-TPQKRLDQ-Ex---QDA- SD-D-xxxxKRIRFSGVKNKTQRQKIAEE--I---GIEGSDDEALDxx-G HDEEVSRWEQEQIRKGISIPQVQSSQPEET-PVYYQNSYETQPYGSSYSM PFTY--STVxxxxxxxxxxxxxxxxxxx-x-------------------- -------PICDLTPISIDLVKKRLQE-R---------------------- ------------------------------------------LGHMHTGH NANVKRYKQIKEDLAASESVIQQLEGSSNNNAEQYKFLQEMRGYVGDLLE CFSEKVPAVLELEAAMHQLLRQRASRLVQRRQDDIKDESAEFASLS---- ---------------NKAVMAPSLDSLGRDRAAYQEHNRQRRIAERE--- ---ARR-TRR-RQAREQNGKRAEHKEGLSSDDEETSTDITSFDMEK--DR IVRESKKIFEDVLEDFHSLDCIKDRFEEWRKEYPGCYRDAYIGLCLPRLF SPLVRLQLITWNPLE----------------------------------- -VPCANFEYMLWFESLLFYGFDEHSx-LEKDDGDIGLLPAIVEKVILSKL SVLAEQVWDPLSSS--------------QTARLVAFIHRLLKGYPTVLHG DNRF-----TQELLKMIVLRTRRTLDEDIFLPLYPKNVMDNKNSGAYLFY QRQFWSCVKLLGNILRWEGILSTSCLKDLALDSTLNRYILSALQTTDVGE ENVHKCQKVVECLPVHWFSGLKGQQTLPQLEPLCRYLAHLANCLHRNSIG LSDIERRTSKEQIRDIVKMLRLVNALDHIVAVAAEQ-------------- --G------------IKDIKQLMEVK-x >ENSORLP00000006101 -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ---MF--------------------------------------------- ----------------------------------------KRAKRANFRR RNDSEEDE-------QEQ-------------------------------- -------------------------------------------------- -------xx----------------------------------------- -------------------------------------------------- -----------xxx------------------------------------ -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ------------xxx----------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------xxxx--------------- ----------------------------------------x--------- ---------------------xx-xx------------------------ -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -----x-------------------------------------------- -----------------------xxx------------------------ -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- --------xxx--------xxx---------------------------- -------------------------------------------------- --xxxxxxxxxx-------------------------------------- -------xxxxxxxxxxxxxxxxxxxxxxxx------------------- ----------------------------------------------xxxx --------xxKVS-----------------------------------LL SF-DEE--E-EA-------------------------------------- -----------------------------------------------T-- ------EVFRVKKPNHSKKIVKQLKKEYKE-------------------- --------------------------------DLEKGG------------ -----------------------xxxxxxxx------------------- -----------------xxxxxxxxxxxxxxx------------------ ------------------xxxx---------------------------- ----------------------------------SEHGEEEMEVDS---- -xxxxxxxx----------------------------------------- --------------------xQGxxxxxx------------------xxx xx-------------------xxxxxxNTLSSLSSLKP-----------G EIPDAAFIHAARKRRQLARELGGEAPLVQMD-TPQKRLDQ-Ex---QDA- SD-D-xxxxKRIRFSGVKNKTQRQKIAEE--I---GIEGSDDEALDxx-G QDEEVSRWEQEQIRKGISIPQVQSSQPEEP-TVYYQNSYETQPYGSSYSM PFTY--STVxxxxxxxxxxxxxxxxxxx-x-------------------- -------PICELTPIPIDLVKKRLQE-R---------------------- ------------------------------------------LGHMHAGH NANVKRYTQIKEDLAASESVIQQLEGSSNNNAEQYKFLQEMRGYVGDLLE CFNEKVPAVLELEAAMHQLLRQRASRLVQRRQDDIKDESAEFASLS---- ---------------NKAVMAPSLDSFGRDRAAYQEHSRQRRIAERE--- ---ARR-TRR-RQAREQNGKRAEHKEGLSSDDEETSTDITSFNMEK--DR IVWESKKIFEDVLEDFHSLDCMKNRFEEWRKEYPTCYRDAYIALCLPRLF SPLVRLQLITWNPLE----------------------------------- -VPCANFEYMLWFESLLFYGFDEHSx-LQKEDGDIGLLPAIVEKVILSKL SVLAEQVWDPLSSS--------------QTARLVAFIHRLRKGYPTVLHG DNRY-----TQELLKMIVLRTRRTLDEDIFLPLYPKNVMDNKNSGAYLFY QRQFWSCVKLLGNILQWEGILSTSCLMDLALDSTLNRYILSALQTTDVGE ENVHKCQKVVECLPVHWFSGLKGQQTLPQLEPLCRYLAHLANSLHRSNIG VSDIERRTSKEQIRDIVKMLRLVNALDHIVAVAAEQ-------------- --G------------IKDLKQLMEVK-x >ENSORLP00015015404 -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ---MF--------------------------------------------- ----------------------------------------KRAKRANFRR RNDSEEDE-------QEL-------------------------------- -------------------------------------------------- -------xx----------------------------------------- -------------------------------------------------- -----------xxx------------------------------------ -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ------------xxx----------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------xxxx--------------- ----------------------------------------x--------- ---------------------xx-xx------------------------ -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -----x-------------------------------------------- -----------------------xxx------------------------ -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- --------xxx--------xxx---------------------------- -------------------------------------------------- --xxxxxxxxxx-------------------------------------- -------xxxxxxxxxxxxxxxxxxxxxxxx------------------- ----------------------------------------------xxxx --------xxKVS-----------------------------------LL SF-DEE--E-EA-------------------------------------- -----------------------------------------------T-- ------EVFRVKKPNHSKKIVKQLKKEYKE-------------------- --------------------------------DLEKGG------------ -----------------------xxxxxxxx------------------- -----------------xxxxxxxxxxxxxxx------------------ ------------------xxxx---------------------------- ----------------------------------SEHGEEEMEVDS---- -xxxxxxxx----------------------------------------- --------------------xQGxxxxxx------------------xxx xx-------------------xxxxxxNTLSSLSSLKP-----------G EIPDAAFIHAARKRRQLARELGGEAPLVQMD-TPQKRLDQ-Ex---QDA- SD-D-xxxxKRIRFSGVKNKTQRQKIAEE--I---GIEGSDDEALDxx-G QDEEVSRWEQEQIRKGISIPQVQSSQPEEP-TVYYQNSYETQPYGSSYSM PFTY--STVxxxxxxxxxxxxxxxxxxx-x-------------------- -------PICELTPIPIDLVKKRLQE-R---------------------- ------------------------------------------LGHMHAGH NANVKRYTQIKEDLAASESVIQQLEGSSNNNAEQYKFLQEMRGYVGDLLE CFSEKVPAVLELEAAMHQLLRQRASRLVQRRQDDIKDESAEFASLS---- ---------------NKAVMAPSLDSFGRDRAAYQEHSRQRRIAERE--- ---ARR-TRR-RQAREQNGKRAEHKEGLSSDDEETSTDITSFNMEK--DR IFRESKKIFEDVLEDFHSLDCMKNRFEEWRKEYPTCYRDAYIALCLPRLF SPLVRLQLITWNPLE----------------------------------- -VPCANFEYMLWFESLLFYGFDEHSx-LQKEDGDIGLLPAIVEKVILSKL SVLAEQVWDPLSSS--------------QTARLVAFIHRLRKGYPTVLHG DNRY-----TQELLKMIVLRTRRTLDEDIFLPLYPKNVMDNKNSGAYLFY QRQFWSCVKLLGNILQWEGILSTSCLMDLALDSTLNRYILSALQTTDVGE ENVHKCQKVVECLPVHWFSGLKGQQTLPQLEPLCRYLAHLANSLHRSNIG VSDIERRTSKEQIRDIVKMLRLVNALDHIVAVAAEQ-------------- --G------------IKDLKQLMEVK-x >ENSORLP00020009799 -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ---MF--------------------------------------------- ----------------------------------------KRAKRANFRR RNDSEEDE-------QEQ-------------------------------- -------------------------------------------------- -------xx----------------------------------------- -------------------------------------------------- -----------xxx------------------------------------ -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ------------xxx----------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------xxxx--------------- ----------------------------------------x--------- ---------------------xx-xx------------------------ -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -----x-------------------------------------------- -----------------------xxx------------------------ -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- --------xxx--------xxx---------------------------- -------------------------------------------------- --xxxxxxxxxx-------------------------------------- -------xxxxxxxxxxxxxxxxxxxxxxxx------------------- ----------------------------------------------xxxx --------xxKVS-----------------------------------LL SF-DEE--E-EA-------------------------------------- -----------------------------------------------T-- ------EVFRVKKPNHSKKIVKQLKKEYKE-------------------- --------------------------------DLEKGG------------ -----------------------xxxxxxxx------------------- -----------------xxxxxxxxxxxxxxx------------------ ------------------xxxx---------------------------- ----------------------------------SEHGEEEMEVDS---- -xxxxxxxx----------------------------------------- --------------------xQGxxxxxx------------------xxx xx-------------------xxxxxxNTLSSLSSLKP-----------G EIPDAAFIHAARKRRQLARELGGEAPLVQMD-TPQKRLDQ-Ex---QDA- SD-D-xxxxKRIRFSGVKNKTQRQKIAEE--I---GIEGSDDEALDxx-G QDEEVSRWEQEQIRKGISIPQVQSSQPEEP-TVYYQNSYETQPYGSSYSM PFTY--STVxxxxxxxxxxxxxxxxxxx-x-------------------- -------PICELTPIPIDLVKKRLQE-R---------------------- ------------------------------------------LGHMHAGH NANVKRYTQIKEDLAASESLIQQLEGSSNNNAEQYKFLQEMRGYVGDLLE CFSEKVPAVLELEAAMHQLLRQRASRLVQRRQDDIKDESAEFASLS---- ---------------NKAVMAPSLDSFGRDRAAYQEHSRQRRIAERE--- ---ARR-TRR-RQAREQNGKRAEHKEGLSSDDEETSTDITSFNMEK--DR IVWESKKIFEDVLEDFHSLDCMKNRFEEWRKEYPTCYRDAYIALCLPRLF SPLVRLQLITWNPLE----------------------------------- -VPCANFEYMLWFESLLFYGFDEHSx-LQKEDGDIGLLPAIVEKVILSKL SVLAEQVWDPLSSS--------------QTARLVAFIHRLRRGYPTVLHG DNRY-----TQELLKMIVLRTRRTLDEDIFLPLYPKNVMDNKNSGAYLFY QRQFWSCVKLLGNILQWEGILSTSCLMDLALDSTLNRYILSALQTTDVGE ENVHKCQKVVECLPVHWFSGLKGQQTLPQLEPLCRYLAHLANSLHRSNMG VSDIERRTSKEQIRDIVKMLRLVNALDHIVAVAAEQ-------------- --G------------IKDLKQLMEVK-x >ENSMAMP00000028566 -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ---MF--------------------------------------------- ----------------------------------------KKAKRANFRR RNDSDEDE-------QEE-------------------------------- -------------------------------------------------- -------xxx--------------------xx------------------ -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ------------xxx----------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------xxxx--------------- ----------------------------------------x--------- ---------------------xxxxx------------------------ -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -----x-------------------------------------------- -----------------------xxx------------------------ -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ---------------------------------------------xxxxx xxxxxxxxxxxx-------------------------------------- -------xxxxxxxxxxxxxxxxxxxxxx--------------------- -------------------------------------------------- --xxxxxxxxKAS-----------------------------------LL SF-DDE--E-EG-------------------------------------- -----------------------------------------------S-- ------EVFRVKKSNHSKKIVKQLKKEYKE-------------------- --------------------------------DLERSG------------ -----------------------xxxxxxxx------------------- -----------------xxxxxxxxxxxxxxx------------------ ------------------xxxx---------------------------- ----------------------------------SEQGEEEMEVDS---- ADEQExxxx----------------------------------------- --------------------xQG----GQAH------------------- --------------SQVSxxxxxxxxxNTISSLGSLRP-----------G EIPDAAFIHAARKRRQMARELGGETPLIETE-APKKRLVR-Ex---QDV- SD-DEDEEEKRIRFSGVRNKSQRQKIAEE--I---GIQGSDDEALD-T-x QDEEVSRWEQEQIRKGISIPQVQSTQPEDN-TVYYQNSYESQPYGSSYSM AFTY--STVxxxxxxxxxxxxxxxxxxx-x-------------------- -------PISDLAPVSTDLVKKRLRD-R---------------------- ------------------------------------------LSQMCAGH NANAKRYKQIEEDLAASESTIQQLEASSNDNADQYKFLQEMRGYVGDLLE CFSEKVPAVLELEAAMHQLLRQRASRLVQRRQDDIKDESSEFASLS---- ---------------NKAVMAPNLDSFGRDRAAYQEHSRQRRIAERE--- ---ARR-TRR-RQAREQNGKRTEHKEGLSSDDEETSTDITSFNMEK--DR IIRECKKVFEDVVEDFHSLDFIKSHFEVWRRDYADSYRDAYIGLCLPKLF NPLVRLQLITWNPLE----------------------------------- -TQCANFEYMLWFESLLFYGFEEHSx-LQRGDGDIGLLPAIVEKVILSKL TVLAEQVWDPLSSS--------------QTTRLVGFIQRLMKGYPTVLHG DNRY-----TQELLKTIVLRTRRTLDEDVFLPLYPKNVLENKNSSPYLFY ERQFWSCVKLLGNILQWEGILSSSCLKDLALDSTLNRYILSALQTTDTAE DNVQKCQKVVESLPAHWFSGLKNQQTLPQLEPFCRYLAHLANSLYRSTMG KSDVERRTAKEQVKEVVKMLGHMNALDHIVTVASEH-------------- --G------------IKDIKTLLEAK-x >ENSSLDP00000020401 -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ---MF--------------------------------------------- ----------------------------------------KKAKRANFRR RNESDEDE-------QEE-------------------------------- -------------------------------------------------- -------xxx--------------------xx------------------ -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ------------xxx----------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------xxxx--------------- ----------------------------------------x--------- ---------------------xxxxx------------------------ -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -----x-------------------------------------------- -----------------------xxx------------------------ -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ---------------------------------------------xxxxx xxxxxxxxxxxx-------------------------------------- -------xxxxxxxxxxxxxxxxxxxxxx--------------------- -------------------------------------------------- --xxxxxxxxKAS-----------------------------------LL SF-NDD--E-EG-------------------------------------- -----------------------------------------------S-- ------EVFRVKKSNHSKKIVKQLKKEYKE-------------------- --------------------------------DLEKSG------------ -----------------------x-------------------------- ----------------------xxxxxxxxxx------------------ ------------------xxxx---------------------------- ----------------------------------SEQGEEEMEVDS---- ADEQExxxx----------------------------------------- --------------------xxx----xxxx------------------- --------------------------------------xxxxxxxxxxxG EIPDAAFIHAARKRRQMARELGGEAPLVETE-TPKKRLVR-Ex---QDA- SD-DEDEEEKRIRFSGVRNKSQRQKIAEE--I---GIEGSDDEALD-T-x QDEEVSRWEQEQIRKGISIPQVQSNQPEDN-TVYYQNSYETQPYGSSYSM PFTY--STVxxxxxxxxxxxxxxxxxxx-x-------------------- -------PISDLTPVSIDLVKKRLQD-R---------------------- ------------------------------------------LSQMHAGH NANAKRYKQIEDDLAASESTIQQLEGSSNDNADQYKFLQEMRGYVGDLLE CFSEKVPAVLELEAAMHQLLRQRASRLVQRRQDDIKDESSEFASLS---- ---------------NKAVMAPNLDSFGRDRAAYQEHSRQRRIAERE--- ---ARR-TRR-RQAREQNGKRAEHKEGLSSDDEETSTDITSFNMER--DR IVRECKKVFEDVVEDFHSLDCIKSHFEVWRRDYADCYRDAYIGLCLPKLF NPLVRLQLITWNPLE----------------------------------- -AQCANFEYMLWFESLLFYGFEEHSx-LQSGDGDIILLPAIVEKVILSKL TVLTEQVWDPLSSS--------------QTARLVGFVHRLMKGYPTVLQG DNRY-----TQELLKTIVLRTRRTLDEDVFLPLYPKNVLENKNSGPYLFY QRQFWSCVKLLGDILQWDGILSSSCLKDLALDSTLNRYILSALQTTDTAE DNVQKCQKVVECLPVQWFSGLKGQQTLPQLEPFCRYLTHLANSLHRSSVG GSDVERRS----VKELVKMLGHMNGLDHIITLAAEH-------------- --G------------IKDIKPLLEAK-x >ENSSDUP00000004156 -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ---MF--------------------------------------------- ----------------------------------------KKAKRANFRR RNESDEDE-------QEE-------------------------------- -------------------------------------------------- -------xxx--------------------xx------------------ -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ------------xxx----------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------xxxx--------------- ----------------------------------------x--------- ---------------------xxxxx------------------------ -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -----x-------------------------------------------- -----------------------xxx------------------------ -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ---------------------------------------------xxxxx xxxxxxxxxxxx-------------------------------------- -------xxxxxxxxxxxxxxxxxxxxxx--------------------- -------------------------------------------------- --xxxxxxxxKAS-----------------------------------LL SF-NDD--E-EG-------------------------------------- -----------------------------------------------S-- ------EVFRVKKSNHSKKIVKQLKKEYKE-------------------- --------------------------------DLEKSG------------ -----------------------xxxxxxxx------------------- -----------------xxxxxxxxxxxxxxx------------------ ------------------xxxx---------------------------- ----------------------------------SEQGEEEMEVDS---- ADEQExxxx----------------------------------------- --------------------xQG----GQAQ------------------- --------------GQVSxxxxxxxxxNTLSSLGSLKP-----------G EIPDAAFIHAARKRRQMARELGGEAPLVETE-APKKRLVR-Ex---QDA- SD-DEDEEEKRIRFSGVRNKSQRQKIAEE--I---GIEGSDDEALD-T-x QDEEVSRWEQEQIRKGISIPQVQSNQPEDN-TVYYQNSYETQPYGSSYSM PFTY--STVxxxxxxxxxxxxxxxxxxx-x-------------------- -------PISDLTPVSIDLVKKRLQD-R---------------------- ------------------------------------------LSQMHAGH NANAKRYKQIEDDLAASESTIQQLEGSSNDNADQYKFLQEMRGYVGDLLE CFSEKVPAVLELEAAMHQLLRQRASRLVQRRQDDIKDESSEFASLS---- ---------------NKAVMAPNLDSFGRDRAAYQEHSRQRRIAERE--- ---ARR-TRR-RQAREQNGKRAEHKEGLSSDDEETSTDITSFNMER--DR IVRECKKVFEDVVEDFHSLDCIKSHFEVWRRDYADCYRDAYIGLCLPKLF NPLVRLQLITWNPLE----------------------------------- -AQCANFEYMLWFESLLFYGFEEHSx-LQSGDGDIILLPAIVEKVILSKL TVLTEQVWDPLSSS--------------QTARLVGFVHRLMKGYPTVLQG DNRY-----TQELLKTIVLRTRRTLDEDVFLPLYPKNVLENKNSGPYLFY QRQFWSCVKLLGDILQWDGILSSSCLKDLALDSTLNRYILSALQTTDTAE DNVQKCQKVVECLPVQWFSGLKGQQTLPQLEPFCRYLTHLANSLHRSSVG GSDVERRSAKDQVKELVKMLGHMNGLDHIITLAAEH-------------- --G------------IKDIKPLLEAK-x >ENSLCAP00010022547 -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ---MF--------------------------------------------- ----------------------------------------KKAKRANFRR RNESDEDE-------QEE-------------------------------- -------------------------------------------------- -------xxx--------------------xx------------------ -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ------------xx------------------------------------ -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- --------------------------------xxx--------------- ----------------------------------------x--------- ---------------------xxxxx------------------------ -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -----x-------------------------------------------- -----------------------xxx------------------------ -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ---------------------------------------------xxxxx xxxxxxxxxxxx-------------------------------------- -------xxxxxxxxxxxxxxxxxxxxxx--------------------- -------------------------------------------------- --xxxxxxxxKAS-----------------------------------LL SF-NDD--E-EG-------------------------------------- -----------------------------------------------S-- ------EVFRVKKSNHSKKIVKQLKKEYKE-------------------- --------------------------------DLERSG------------ -----------------------xxxxxxxx------------------- -----------------xxxxxxxxxxxxxxx------------------ ------------------xxxx---------------------------- ----------------------------------SEQGEEEMEVDS---- ADEQExxxx----------------------------------------- --------------------xQG----GQAH------------------- --------------SQVSxxxxxxxxxNTLSSLGSLRP-----------G EIPDAAFIHAARKRRQMARELGGETPLVETE-TPKKRLVR-Ex---QDA- SD-DEDEEEKRIRFSGVRNKSQRQKIAEE--I---GIEGSDDEALD-T-x QDEEVSRWEQEQIRKGISIPQVQSNQPEDN-TVYYQNSYESQPYGSSYSM PFTY--STVxxxxxxxxxxxxxxxxxxx-x-------------------- -------PISDLTPVPIDLVKKRLQD-R---------------------- ------------------------------------------LSQMRAGH NANAKRYKQIEEDLAASEGTIQQLEGSSNDNADQYKFLQEMRGYVGDLLE CFSEKVPAVLELEAAMHQLLRQRASRLVQRRQDDIKDESSEFASLS---- ---------------NKAVMAPNLDSFGRDRAAYQEHSRQRRIAERE--- ---ARR-TRR-RQAREQNGKRAEHKEGLSSDDEETSTDITSFNMER--DR IIRECKKVFEDVVEDFHSLDCIKSHFEVWRRDYADCYRDAYIGLCLPKLF NPLVRLQLITWNPLE----------------------------------- -AQCANFEYMLWFESLLFYGFEEHSx-LQRGDGDISLLPAIVEKVILSKL TVLTEQVWDPLSSS--------------QTARLVGFIHRLMKGYPTVLHG DNRY-----TQELLKTIVFRTRRTLEEDVFLPLYPKNVLENKNSSPYLFY QRQFWSCVKLFGNILQWEGILSSSCLRDLALDSTLNRYILSALQTTDTGE DNVQKCQKVAECLPVQWFSGLKGQQTLPQLEPFCRYLTHLANSLHRGSVG GSDVERRTAKEQIKEVVKMLGHMNALDHIIAVAAEH-------------- --G------------IKDIKPLLEAK-x >ENSLCRP00005061600 -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ---MF--------------------------------------------- ----------------------------------------KKAKRANFRR RNESDEDExxxxxxxxxx-------------------------------- -------------------------------------------------- -------xxx--------------------xx------------------ -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -----------xxxx----------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------xxxx--------------- ----------------------------------------x--------- ---------------------xxxxx------------------------ -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -----x-------------------------------------------- -----------------------xxx------------------------ -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ---------------------------------------------xxxxx xxxxxxxxxxxx-------------------------------------- -------xxxxxxxxxxxxxxxxxxxxxx--------------------- -------------------------------------------------- --xxxxxxxxKAS-----------------------------------LL SF-DDD--E-EG-------------------------------------- -----------------------------------------------S-- ------EVFRVKKSNHSKKIVKQLKKEYKE-------------------- --------------------------------DLEKSG------------ -----------------------xxxxxxxx------------------- -----------------xxxxxxxxxxxxxxx------------------ ------------------xxxx---------------------------- ----------------------------------SEQGEEEMEVDS---- TDEQExxxx----------------------------------------- --------------------xHG----GQAH------------------- --------------GQVSxxxxxxxxxNTLSSLGSLRP-----------G EIPDAAFIHAARKRRQLARELGGEAPLVETE-TPKKRLIG-Ex---QDA- SD-DEDEEEKRIRFSGVKNKSQRQKIAEE--I---GIEGSDDEALD-T-x QDEEVSRWEQEQIRKGISIPQVQSNQPEDN-TVYYQNSYESQPYGSSYSM PFTY--STVxxxxxxxxxxxxxxxxxxx-x-------------------- -------PISDLTPVSIDLVKKRLQD-R---------------------- ------------------------------------------LGQMHASH NANAKRYKQIEEDLAASESTIQQLEGSSNDNADQYKFLQEMRGYVGDLLE CFSEKVPAVLELEAAMHQLLRQRASRLVQRRQDDIKDESSEFASLS---- ---------------NKAVMAPNLDSFGRDRAAYQEHSRQRRIAERE--- ---ARR-TRR-RQAREQNGKRAEHNEGLSSDDEETSTDITSFNMER--DR IIRECKKVFEDVVEDFHSLDCIKSHFEVWRREYADCYRDAYIGLCLPRLF NPLVRLQLITWNPLQ----------------------------------- -GQCENFEYMLWFESLLFYGFEEHSx-LQKGDGDISLLPAIVEKVILSKL TVLAEQVWDPLSSS--------------QTASLVGFIHRLMKGYPTVLHG DNRY-----TQELLKMIVLRTRRTLDEDVFLPLYPKIVLENKNSGPYLFY QRQFWSCVKLLGNILQWEGILSNSCLRDLALDSTLNRYILSALQTTDTGE DNIPKCHKVVECIPVHWFSGLKGQQTLPQLEPFCRYLTHLANSLHRSSFG APDVERRTAKDQIKEVVRMLGHMNALDHIITVAAEL-------------- --G------------IKDIKPLLEAK-x >ENSAPEP00000031883 -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ---MF--------------------------------------------- ----------------------------------------KKAKRANFRR RNESDEDE-------QEE-------------------------------- -------------------------------------------------- -------xxx--------------------xx------------------ -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -----------xxxx----------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------xxxx--------------- ----------------------------------------x--------- ---------------------xx-xx------------------------ -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -----x-------------------------------------------- -----------------------xxx------------------------ -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ---------------------------------------------xxxxx xxxxxxxxxxxx-------------------------------------- -------xxxxxx--xxxxxxxxxxxxxx--------------------- -------------------------------------------------- --xxxxxxxxKAS-----------------------------------LL SF-DDD--E-EG-------------------------------------- -----------------------------------------------S-- ------EVFRVKKSNHSKKIVKQLKKEYKE-------------------- --------------------------------DLERSG------------ -----------------------xxxxxxxx------------------- -----------------xxxxxxxxxxxxxxx------------------ ------------------xxxx---------------------------- ----------------------------------SEQGEEEMEVDS---- ADEHExxxx----------------------------------------- --------------------xQG----GQTQ------------------- --------------SQASxxxxxxxxxNTLSTLGSLRP-----------G EIPDAAFIHAARKRRQLARELGGETPLVETE-TPKKRLVR-Ex---QDA- SD-DEDEEEKRIRFSGVRNKSQRQKIAEE--I---GIEGSDDEALD-A-x QDEEVSRWEQEQIRKGISIPQVQSSQPEDN-TVYYQNSYESQPYGASYSI PFTY--STVxxxxxxxxxxxxxxxxxxx-x-------------------- -------VISDLTPVSIDLVKKRLQD-R---------------------- ------------------------------------------LNQMHAGH NANTRRYKQIKEELAASESTIQQLEGSSNDNADQYKFLQEMRGYVGDLLE CFSEKVPAVLELEAAMHQLLRQRASRLVQRRQDDIKDESSEFASLS---- ---------------NKAVMAPNLDSFGRDRAAYQEHSRQRRIAERE--- ---ARR-TRR-RQAREQNGKRAEHNEGLSSDDEETSTDITSFNMER--DR IIRECKKVFEDVVEDFHSLDCIKSHFEVWRREYADCYRDAYIGLCLPKLF NPLVRLQLIAWNPLE----------------------------------- -AQCANFEYMLWFESLLFYGFEEHSx-LQKGDGDIGLLPAIVEKVILSKL TVLAEQVWDPLSSS--------------QTARLVGFIHRLMKGYPTVLHG DNQY-----TQELLKTIVLRTRRTLDEDVFLPLYPKNILENKNSGPYLFY QRQFWSCVKLLGNILQWECILSSSCLRDLALDSTVNRYILSALQTTDTAE ENVQKCQKVVECLPTHWFSGLKGQQTLPQLEPLCRYLTHLANSMHRSSLG GSDIERRTSKEQIKEVVKMLGQMNALDHIIAVAAEH-------------- --G------------IKDIKPLLEAK-x >ENSAOCP00000012533 -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ---MF--------------------------------------------- ----------------------------------------KKAKRANFRR RNESDEDE-------QEE-------------------------------- -------------------------------------------------- -------xxx--------------------xx------------------ -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -----------xxxx----------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------xxxx--------------- ----------------------------------------x--------- ---------------------xx-xx------------------------ -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -----x-------------------------------------------- -----------------------xxx------------------------ -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ---------------------------------------------xxxxx xxxxxxxxxxxx-------------------------------------- -------xxxxxx--xxxxxxxxxxxxxx--------------------- -------------------------------------------------- --xxxxxxxxKAS-----------------------------------LL SF-DDD--E-EG-------------------------------------- -----------------------------------------------S-- ------EVFRVKKSNHSKKIVKQLKKEYKE-------------------- --------------------------------DLERSG------------ -----------------------xxxxxxxx------------------- -----------------xxxxxxxxxxxxxxx------------------ ------------------xxxx---------------------------- ----------------------------------SEQGEEEMEVDS---- ADEHExxxx----------------------------------------- --------------------xQG----GQTQ------------------- --------------SQASxxxxxxxxxNTLSTLGSLRP-----------G EIPDAAFIHAARKRRQLARELGGETPLVETE-TPKKRLVR-Ex---QDA- SD-DEDEEEKRIRFSGVRNKSQRQKIAEE--I---GIEGSDDEALD-A-x QDEEVSRWEQEQIRKGISIPQVQSSQPEDN-TVYYQNSYESQPYGASYSI PFTY--STVxxxxxxxxxxxxxxxxxxx-x-------------------- -------VISDLTPVSIDLVKKRLQD-R---------------------- ------------------------------------------LNQMHAGH NANTRRYKQIKEELAASESTIQQLEGSSNDNADQYKFLQEMRGYVGDLLE CFSEKVPAVLELEAAMHQLLRQRASRLVQRRQDDIKDESSEFASLS---- ---------------NKAVMAPNLDSFGRDRAAYQEHSRQRRIAERE--- ---ARR-TRR-RQAREQNGKRAEHNEGLSSDDEETSTDITSFNMER--DR IIRECKKVFEDVVEDFHSLDCIKSHFEVWRREYADCYRDAYIGLCLPKLF NPLVRLQLIAWNPLE----------------------------------- -AQCANFEYMLWFESLLFYGFEEHSx-LQKGDGDIGLLPAIVEKVILSKL TVLAEQVWDPLSSS--------------QTARLVGFIHRLMKGYPTVLHG DNQY-----TQELLKTIVLRTRRTLDEDVFLPLYPKNILENKNSGPYLFY QRQFWSCVKLLGNILQWECILSSSCLRDLALDSTVNRYILSALQTTDTAE ENVQKCQKVVECLPTHWFSGLKGQQTLPQLEPFCRYLTHLANSMHRSSLG GSDIERRTSKEQIKEVVKMLGQMNALDHIIAVAAEH-------------- --G------------IKDIKPLLEAK-x >ENSSPAP00000005030 -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ---MF--------------------------------------------- ----------------------------------------KKAKRVNLRR RNESDEEE-------QEE-------------------------------- -------------------------------------------------- -------xxx--------------------xx------------------ -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -----------xxxx----------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------xxxx--------------- ----------------------------------------x--------- ---------------------xx-xx------------------------ -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -----x-------------------------------------------- -----------------------xxx------------------------ -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ---------------------------------------------xxxxx xxxxxxxxxxxx-------------------------------------- -------xxxxxx--xxxxxxxxxxxxxx--------------------- -------------------------------------------------- --xxxxxxxxKAS-----------------------------------LL SF-DDE--E-EG-------------------------------------- -----------------------------------------------S-- ------EVFRVKKSNHSKKIVKQLKKEYKE-------------------- --------------------------------DLERSG------------ -----------------------xxxxxxxx------------------- -----------------xxxxxxxxxxxxxxx------------------ ------------------xxxx---------------------------- ----------------------------------SEQGEEEMEVDS---- ADEHExxxx----------------------------------------- --------------------xQG----GQAQ------------------- --------------SQASxxxxxxxxxNTLSSLGSLRP-----------G EIPDAAFIHAARKRRQLARELGGETPLVETE-TPKKRLVR-Ex---QDV- SD-DEDEEEKRIRFSGVRNKSQRQKIAEE--I---GIEGSDDEALE-P-x QDEEVSRWEQEQIRKGISIPQVQSSQPEDT-TVYYQNSYESQPYGASYSI PFTY--STVxxxxxxxxxxxxxxxxxxx-x-------------------- -------LVSDLTPVSIDLVKKRLQD-R---------------------- ------------------------------------------LNHMHAGH NANAKRYKQIKDELAASESTIQQLEGSSNDNADQYKFLQEMRGYVGDLLE CFSEKVPAVLELEAAMHQLLRQRASRLVQRRQDDIKDESSEFASLS---- ---------------NKAVMAPNLDSFGRDRAAYQEHSRQRRIAERE--- ---ARR-TRR-RQAREQNGKRAEHNEGFSSDDEETSTDITSFNMEK--DR IIKECKKVFEDVVEDFHSLDCIKSHFEVWRREYADCYRDAYIGLCLPKLF NPLVRLQLIAWNPVE----------------------------------- -TQCANFEYMLWFESLLFYGFEEHSx-LQKGDGDIGLLPAIVEKVILSKL TVLAEQVWDPLSSS--------------QTARLVGFIHRLMKGYPTVLHG DNQY-----TQELLKTIVLRTRRTLDEDVFLPLYPKNVLENKNSGPYLFY QRQFWSCVKLLGNILQWESVLSSSCLRDLALDSTLNRYILSALQTTDTAE ENVQKCQKVAECLPAHWFSGLKGQQTLPQLEPFCRYLTHLANSMHRSSLG GSDVERRTSKEQIKEVVKMLGQMNALNHIIAVAAEH-------------- --G------------IKDIKPLLEAK-x >ENSSMAP00000014661 -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ---MF--------------------------------------------- ----------------------------------------KKAKRANFRR RNESDEDE-------PEA-------------------------------- -------------------------------------------------- -------xxx--------------------xx------------------ -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ------------xxx----------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------xxxx--------------- ----------------------------------------x--------- ---------------------xxxxx------------------------ -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -----x-------------------------------------------- -----------------------xxxxxxx-------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -----xxxxx---------------------------------------- ------xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx----- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -----xxxxxKAS-----------------------------------LL SF-HDD--E-EG-------------------------------------- -----------------------------------------------S-- ------EVFRVKKPNHSKKIVKQLKKEYKE-------------------- --------------------------------DLEKSG------------ -----------------------xxxxxxxx------------------- -----------------xxxxxxxxxxxxxxx------------------ ------------------xxxx---------------------------- ----------------------------------SEQGEEEMEVDS---- AEEHDxxxxxxx-------------------------------------- xxxxx-------------xx------------------------------ ------------------------xxxNTLSSLGSLRP-----------G EIPDAAFIHAARKRRQLARELGGETPLVETE-APKKRLVG-Ex---QDA- SD-DEDEEEKRIRFSGVKNKSQRQKIAEE--I---GIEGSDDEALD-T-x QDEEVSRWEQEQIRKGISIPQVQSSQPEDN-TVYYQNSYESQPYGSSYSM PFTY--STVxxxxxxxxxxxxxxxxxxx-x-------------------- -------PVSDLTPVSIDLVKKRLQD-R---------------------- ------------------------------------------LGQMSVGH NANSRRYKEIEDDLAASESTIRQLEGSSNVNAEQYKFLQEMRGYVGDLLE CFSEKVPAVLELEAAMHQLLRQRAARLVQRRQDDIKDESAEFASLS---- ---------------NKAVMAPNLDSFGRDRAAYQEHSRQRRIAERE--- ---ARR-TRR-RQAREQNGKRAEHKEGLSSDDEETSTDITSFNMEK--DR INRDCKKVFEDVVEDFHSLDFIKSHFEVWRRNYADCYRDAYIGLCLPKLF NPLVRLQLITWNPLE----------------------------------- -APCANFEYMLWFESLLFYGFEEHGx-LQRGDGDISLLPAIVEKVILSKL TVLTEQVWDPLSSS--------------QTARLVGFVRRLMKGYPTVLHG ENRY-----TEELLKSIVLRTRRTLDEDVFLPLYPKNVLENKNSGPYLFY QRQFWSCVKLLGNILQWEGILSTSCLKDLALDSTLNRYILSALQTTDTAE DNVQKCQKVVECLPVHWFSGLKGQQTLPQLEPFCRYLTHLANSLQRSTVG GSDVERRTAKEQVKESVKMLGHMNALDHILTVAAEH-------------- --G------------IKDIKPLLEAM-x >ENSMZEP00005025913 -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ---MF--------------------------------------------- ----------------------------------------KKAKRANFRR RNESDEDE-------QEE-------------------------------- -------------------------------------------------- -------xxx--------------------xx------------------ -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ------------xxx----------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------xxxx--------------- ----------------------------------------x--------- ---------------------x--xx------------------------ -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -----x-------------------------------------------- -----------------------xxx------------------------ -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ---------------------------------------------xxxxx xxxxxxxxxxxx-------------------------------------- -------xxxxxx--xxxxxxxxxxxxxx--------------------- -------------------------------------------------- --xxxxxxxxKAS-----------------------------------LL SF-VDE--E-DG-------------------------------------- -----------------------------------------------S-- ------EVFRVKKSNHSKKILKQLKKEYKE-------------------- --------------------------------DLERSG------------ -----------------------xxxxxxxx------------------- -----------------xxxxxx--xxxxxxx------------------ ------------------xxxx---------------------------- ----------------------------------SEQGEEEMEVES---- ADEQExxxx----------------------------------------- --------------------xQS----GQTN------------------- --------------SQVSxxxxxxxxxNTLSTLGSLRP-----------G EIPDAAFIHAARKRRQLARELGGDAPLVETE-APKKRLVR-Ex---QDA- SD-DEDEEEKRIRFSGVRNKSQRQKIAEE--I---GIEGSDDEALD-T-x QDEEVSRWEQEQIRKGISIPQVQSSQPEDS-TVYYQNSYESQPYGSSYSM PYTY--STVxxxxxxxxxxxxxxxxxxx-x-------------------- -------SLNDLIPVSIDLVKKRLQD-R---------------------- ------------------------------------------LSQMHAGH NGNVDRYKQINEDLAASERTIQQLEDSSNDNAEQYKFLQEMRGYVGDLLE CFSEKVPAVLELEAAMHQLLRQRATRLVQRRQDDIKDESSEFASLS---- ---------------NKAVMAPNLDSFGRDRAAYQEHSRQRRIAERE--- ---ARR-TRR-RQAREQNGKRAEHKEGLSSDDEETSTDITSFNMER--DR IIRESKKVFEDVVEDFHSLDYIKSHFEVWRKEYANTYRDAYIGLCLPKLF NPLVRLQLITWNPLE----------------------------------- -AQCANFEYMLWFESLLFYGFEENSx-LQKGDGDIGLLPAIVEKVILSKL SVLAEQVWDPLSSS--------------QTTRFVSFIHRLLKGYPTVLHG DNRY-----TQELLKTIVLRTRRTLDEDVFLPLYPKNILENKNSGPYLFY QRQFWSCVKLLGNILQWDGILSMSSLKDLALDSTLNRYILSALQTTDTWE ENIQKCQKVVECLPSHWFSGLKGQQTLPQLEPFCRYLTHLANSIHRSALV GSDIERRTSKEQVKDVVKMLGQMNALDHIIAVAAEH-------------- --G------------IKDIKPLLEVK-x >ENSACLP00000034019 -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ---MF--------------------------------------------- ----------------------------------------KKAKRANFRR RNESDEDE-------QEE-------------------------------- -------------------------------------------------- -------xxx--------------------xx------------------ -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ------------xxx----------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------xxxx--------------- ----------------------------------------x--------- ---------------------x--xx------------------------ -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -----x-------------------------------------------- -----------------------xxx------------------------ -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ---------------------------------------------xxxxx xxxxxxxxxxxx-------------------------------------- -------xxxxxx--xxxxxxxxxxxxxx--------------------- -------------------------------------------------- --xxxxxxxxKAS-----------------------------------LL SF-VDE--E-DG-------------------------------------- -----------------------------------------------S-- ------EVFRVKKSNHSKKILKQLKKEYKE-------------------- --------------------------------DLERSG------------ -----------------------xxxxxxxx------------------- -----------------xxxxxx--xxxxxxx------------------ ------------------xxxx---------------------------- ----------------------------------SEQGEEEMEVES---- ADEQExxxx----------------------------------------- --------------------xQS----xxxx------------------- --------------SxVSxxxxxxxxxNTLSTLGSLRP-----------G EIPDAAFIHAARKRRQLARELGGDAPLVETE-APKKRLVR-Ex---QDA- SD-DEDEEEKRIRFSGVRNKSQRQKIAEE--I---GIEGSDDEALD-T-x QDEEVSRWEQEQIRKGISIPQVQSSQPEDS-TVYYQNSYESQPYGSSYSM PYTY--STVxxxxxxxxxxxxxxxxxxx-x-------------------- -------SLNDLIPVSIDLVKKRLQD-R---------------------- ------------------------------------------LSQMHAGH NGNVDRYKQINEDLAASERTIQQLEDSSNDNAEQYKFLQEMRGYVGDLLE CFSEKVPAVLELEAAMHQLLRQRATRLVQRRQDDIKDESSEFASLS---- ---------------NKAVMAPNLDSFGRDRAAYQEHSRQRRIAERE--- ---ARR-TRR-RQAREQNGKRAEHKEGLSSDDEETSTDITSFNMER--DR IIRESKKVFEDVVEDFHSLDYIKSHFEVWRKEYANTYRDAYIGLCLPKLF NPLVRLQLITWNPLE----------------------------------- -AQCANFEYMLWFESLLFYGFEENSx-LQKGDGDIGLLPAIVEKVILSKL SVLAEQVWDPLSSS--------------QTTRFVSFIHRLLKGYPTVLHG DNRY-----TQELLKTIVLRTRRTLDEDVFLPLYPKNILENKNSGPYLFY QRQFWSCVKLLGNILQWDGILSMSSLKDLALDSTLNRYILSALQTTDTWE ENIQKCQKVVECLPSHWFSGLKGQQTLPQLEPFCRYLTHLANSIHRSALV GSDIERRTSKEQVKDVVKMLGQMNALDHIIAVAAEH-------------- --G------------IKDIKPLLEVK-x >ENSNBRP00000012311 -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ---MF--------------------------------------------- ----------------------------------------KKAKRANFRR RNESDEDE-------QEE-------------------------------- -------------------------------------------------- -------xxx--------------------xx------------------ -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ------------xxx----------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------xxxx--------------- ----------------------------------------x--------- ---------------------x--xx------------------------ -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -----x-------------------------------------------- -----------------------xxx------------------------ -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ---------------------------------------------xxxxx xxxxxxxxxxxx-------------------------------------- -------xxxxxx--xxxxxxxxxxxxxx--------------------- -------------------------------------------------- --xxxxxxxxKAS-----------------------------------LL SF-VDE--E-DG-------------------------------------- -----------------------------------------------S-- ------EVFRVKKSNHSKKIVKQLKKEYKE-------------------- --------------------------------DLERSG------------ -----------------------xxxxx---------------------- ----------------------x--xxxxxxx------------------ ------------------xxxx---------------------------- ----------------------------------SEQGEEEMEVES---- ADEQExxxx----------------------------------------- --------------------xxx----xxxxxx-------xx---xxx-- -------------x-----------------------P-----------G EIPDAAFIHAARKRRQLARELGGDAPLVETE-TPKKRLVR-Ex---QDA- SD-DEDEEEKRIRFSGVRNKSQRQKIAEE--I---GIEGSDDEALD-T-x QDEEVSRWEQEQIRKGISIPQVQSSQPEDS-TVYYQNSYESQPYGSSYSM PYTY--STVxxxxxxxxxxxxxxxxxxx-x-------------------- -------PLNDLIPVSIDLVKKRLQD-R---------------------- ------------------------------------------LSQMHAGH NGNVDRYKQINEDLAASERTIQQLEDSSNDNAEQYKFLQEMRGYVGDLLE CFSEKVPAVLELEAAMHQLLRQRATRLVQRRQDDIKDESSEFASLS---- ---------------NKAVMAPNLDSFGRDRAAYQEHSRQRRIAERE--- ---ARR-TRR-RQAREQNGKRAEHKEGLSSDDEETSTDITSFNMER--DR IIRESKKVFEDVVEDFHSLDYIKSHFEVWRKEYANTYRDAYIGLCLPKLF NPLVRLQLITWNPLE----------------------------------- -AQCANFEYMLWFESLLFYGFEENSx-LQKGDGDIGLLPAIVEKVILSKL SVLAEQVWDPLSSS--------------QTTRFVSFIHRLLKGYPTVLHG DNRY-----TQELLKTIVLRTRRTLDEDVFLPLYPKNILENKNSGPYLFY QRQFWSCVKLLGNILQWDGILSTSSLKDLALDSTLNRYILSALQTTDTWE ENIQKCQKVVECLPSHWFSGLKGQQTLPQLEPFCRYLTHLANSIHRSALV GSDIERRTSKEQVKDVVKMLGQMNALDHIIAVAAEH-------------- --G------------IKDIKPLLEVK-x >ENSHBUP00000026725 -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ---MF--------------------------------------------- ----------------------------------------KKAKRANFRR RNESDEDE-------QEE-------------------------------- -------------------------------------------------- -------xxx--------------------xx------------------ -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ------------xxx----------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------xxxx--------------- ----------------------------------------x--------- ---------------------x--xx------------------------ -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -----x-------------------------------------------- -----------------------xxx------------------------ -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ---------------------------------------------xxxxx xxxxxxxxxxxx-------------------------------------- -------xxxxxx--xxxxxxxxxxxxxx--------------------- -------------------------------------------------- --xxxxxxxxKAS-----------------------------------LL SF-VDE--E-DG-------------------------------------- -----------------------------------------------S-- ------EVFRVKKSNHSKKILKQLKKEYKE-------------------- --------------------------------DLERSG------------ -----------------------xxxxx---------------------- ----------------------x--xxxxxxx------------------ ------------------xxxx---------------------------- ----------------------------------SEQGEEEMEVES---- ADEQExxxx----------------------------------------- --------------------xxx----xxxxxx-------xx---xxx-- -------------x-----------------------P-----------G EIPDAAFIHAARKRRQLARELGGDAPLVETE-APKKRLVR-Ex---QDA- SD-DEDEEEKRIRFSGVRNKSQRQKIAEE--I---GIEGSDDEALD-T-x QDEEVSRWEQEQIRKGISIPQVQSSQPEDS-TVYYQNSYESQPYGSSYSM PYTY--STVxxxxxxxxxxxxxxxxxxx-x-------------------- -------SLNDLIPVSIDLVKKRLQD-R---------------------- ------------------------------------------LSQMHAGH NGNVDRYKQINEDLAASERTIQQLEDSSNDNAEQYKFLQEMRGYVGDLLE CFSEKVPAVLELEAAMHQLLRQRATRLVQRRQDDIKDESSEFASLS---- ---------------NKAVMAPNLDSFGRDRAAYQEHSRQRRIAERE--- ---ARR-TRR-RQAREQNGKRAEHKEGLSSDDEETSTDITSFNMER--DR IIRESKKVFEDVVEDFHSLDYIKSHFEVWRKEYANTYRDAYIGLCLPKLF NPLVRLQLITWNPLE----------------------------------- -AQCANFEYMLWFESLLFYGFEENSx-LQKGDGDIGLLPAIVEKVILSKL SVLAEQVWDPLSSS--------------QTTRFVSFIHRLLKGYPTVLHG DNRY-----TQELLKTIVLRTRRTLDEDVFLPLYPKNILENKNSGPYLFY QRQFWSCVKLLGNILQWDGILSMSSLKDLALDSTLNRYILSALQTTDTWE ENIQKCQKVVECLPSHWFSGLKGQQTLPQLEPFCRYLTHLANSIHRSALV GSDIERRTSKEQVKDVVKMLGQMNALDHIIAVAAEH-------------- --G------------IKDIKPLLEVK-x >ENSPNYP00000001753 -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ---MF--------------------------------------------- ----------------------------------------KKAKRANFRR RNESDEDE-------QEE-------------------------------- -------------------------------------------------- -------xxx--------------------xx------------------ -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ------------xxx----------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------xxxx--------------- ----------------------------------------x--------- ---------------------x--xx------------------------ -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -----x-------------------------------------------- -----------------------xxx------------------------ -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ---------------------------------------------xxxxx xxxxxxxxxxxx-------------------------------------- -------xxxxxx--xxxxxxxxxxxxxx--------------------- -------------------------------------------------- --xxxxxxxxKAS-----------------------------------LL SF-VDE--E-DG-------------------------------------- -----------------------------------------------S-- ------EVFRVKKSNHSKKILKQLKKEYKE-------------------- --------------------------------DLERSG------------ -----------------------xxxxx---------------------- ----------------------x--xxxxxxx------------------ ------------------xxxx---------------------------- ----------------------------------SEQGEEEMEVES---- ADEQExxxx----------------------------------------- --------------------xxx----xxxxxx-------xx---xxx-- -------------x-----------------------P-----------G EIPDAAFIHAARKRRQLARELGGDAPLVETE-APKKRLVR-Ex---QDA- SD-DEDEEEKRIRFSGVRNKSQRQKIAEE--I---GIEGSDDEALD-T-x QDEEVSRWEQEQIRKGISIPQVQSSQPEDS-TVYYQNSYESQPYGSSYSM PYTY--STVxxxxxxxxxxxxxxxxxxx-x-------------------- -------SLNDLIPVSIDLVKKRLQD-R---------------------- ------------------------------------------LSQMHAGH NGNVDRYKQINEDLAASERTIQQLEDSSNDNAEQYKFLQEMRGYVGDLLE CFSEKVPAVLELEAAMHQLLRQRATRLVQRRQDDIKDESSEFASLS---- ---------------NKAVMAPNLDSFGRDRAAYQEHSRQRRIAERE--- ---ARR-TRR-RQAREQNGKRAEHKEGLSSDDEETSTDITSFNMER--DR IIRESKKVFEDVVEDFHSLDYIKSHFEVWRKEYANTYRDAYIGLCLPKLF NPLVRLQLITWNPLE----------------------------------- -AQCANFEYMLWFESLLFYGFEENSx-LQKGDGDIGLLPAIVEKVILSKL SVLAEQVWDPLSSS--------------QTTRFVSFIHRLLKGYPTVLHG DNRY-----TQELLKTIVLRTRRTLDEDVFLPLYPKNILENKNSGPYLFY QRQFWSCVKLLGNILQWDGILSMSSLKDLALDSTLNRYILSALQTTDTWE ENIQKCQKVVECLPSHWFSGLKGQQTLPQLEPFCRYLTHLANSIHRSALV GSDIERRTSKEQVKDVVKMLGQMNALDHIIAVAAEH-------------- --G------------IKDIKPLLEVK-x >ENSONIP00000006026 -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ---MF--------------------------------------------- ----------------------------------------KKAKRANFRR RNESDEDE-------QEE-------------------------------- -------------------------------------------------- -------xxx--------------------xx------------------ -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ------------xxx----------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------xxxx--------------- ----------------------------------------x--------- ---------------------x--xx------------------------ -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -----x-------------------------------------------- -----------------------xxx------------------------ -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ---------------------------------------------xxxxx xxxxxxxxxxxx-------------------------------------- -------xxxxxx--xxxxxxxxxxxxxx--------------------- -------------------------------------------------- --xxxxxxxxKAS-----------------------------------LL SF-VDE--xxDS-------------------------------------- -----------------------------------------------S-- ------EVFRVKKSNHSKKIVKQLKKEYKE-------------------- --------------------------------DLERSG------------ -----------------------xxxxxxxxx------------xx---- ------------xxxxxxxxxxx--xxxxxxx------------------ ------------------xxxx---------------------------- ----------------------------------SEQGEEEMEVES---- ADEQEx-------------------------------------------- -------------------------------------------------- -------------------xxxxxxxxNTLSTLGSLRP-----------G EIPDAAFIHAARKRRQLARELGGDAPLVETE-APKKRLVR-Ex---QDA- SD-DEDEEEKRIRFSGVRNKSQRQKIAEE--I---GIEGSDDEALD-T-x QDEEVSRWEQEQIRKGISIPQVQSSQPEDS-TVYYQNSYESQPYGSSYSM PYTY--STVxxxxxxxxxxxxxxxxxxx-x-------------------- -------PLNDLIPVSIDLVKKRLQD-R---------------------- ------------------------------------------VSQMRAGH NANVDRYKQINEDLAASERTIQQLEGSSNDNAEQYKFLQEMRGYVGDLLE CFSEKVPAVLELEAAMHQLLRQRATRLVQRRQDDIKDESSEFASLS---- ---------------NKAVMAPNLDSFGRDRAAYQEHSRQRRIAERE--- ---ARR-TRR-RQAREQNGKRAEHKEGLSSDDEETSTDITSFNMER--DR IIRESKKVFEDVVEDFHSLDYIKSHFEVWRKEFANTYRDAYIGLCLPKLF NPLVRLQLITWNPLE----------------------------------- -AQCANFEYMLWFESLLFYGFEENSx-LQKGDGDIGLLPAIVEKVILSKL SVLAEQVWDPLSSS--------------QTTRFVSFIHRLLKGYPTVLHG DNRY-----TQELLKTIVLRTRRTLDDDVFLPLYPKNILENKNSGPYLFY QRQFWSCVKLLGNILQWDGILSMSSLKDLALDSTLNRYILSALQTTDTWE ENIQKCQKVVECLPSHWFSGLKGQQTLPQLEPFCRYLTHLANSIHRNTLV GSDIERRTSKEQVKDVVKMLGQMNALDHIIAVAAEH-------------- --G------------IKDIKPLLEVK-- >ENSLBEP00000016287 -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ---MF--------------------------------------------- ----------------------------------------KKAKRANFRR RNESDEDE-------LED-------------------------------- -------------------------------------------------- -------xxx--------------------xx------------------ -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ------------xxx----------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------xxxx--------------- ----------------------------------------x--------- ---------------------xxxxx------------------------ -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -----x-------------------------------------------- -----------------------xxx------------------------ -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ---------xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx x----xx------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -----xxxxxKAS-----------------------------------LL SF-VDD--E-EG-------------------------------------- -----------------------------------------------S-- ------DVFRVKKSTHSKKIVKQLKKEYKE-------------------- --------------------------------DLEKSG------------ -----------------------xxxxxxxx------------------- -----------------xxxxxxxxxxxxxxx------------------ ------------------xxxx---------------------------- ----------------------------------SEHGEEEMEVDS---- ADEQExxxx----------------------------------------- --------------------xQG----GQAQ------------------- --------------GQVTxxxxxxxxxNTLSSLGSLKP-----------G EIPDAAFIHAARKRRQLARELGGDAPLVETE-TPKKRLGG-Ex---QDA- SE-DEDDEEKRIRFSGVKNKSQRQKIAEE--I---GIEGSDDEALD-T-x QDEEVSRWEQEQIRKGISIPQVQSSQPEDN-TVYYQNSYESQPYGASYSM PFTY--STMxxxxxxxxxxxxxxxxxxx-x-------------------- -------PFSDLTPVSIDLVKKRLQD-R---------------------- ------------------------------------------LSQMHAGH NANAKRFRQIEEDLAASESSIQHLEGSANDNAEQYKFLQEMRGYVGDLLE CFSEKVPAILELEAAMHQLLRQRASRLVQRRQDDIKDESSEFASLS---- ---------------SKAVMAPSLDSFGRDRTAYQEHSRQRRIAERE--- ---ARR-TRR-RQAREQNGKRAEHKEGLSSDDEETSTDVTSFNIER--DR ISRECKKAFEDVVEDFHSLDCIKSHFEVWRRDYADCYRDAYIGLCLPKLF NPLVRLQLITWNPLG----------------------------------- -ANCANFEYMLWFESLLFYGFEEHSx-LQSGDGDISLLPAIVEKVILSKL TVLAEQVWDPLSSS--------------QTASLVGFIHRLMKGYPTVLHG DNRY-----TQELLKTVVLRARRTLDEDVFLPLYPKNVLENKNSGPYLFY QRQFWSCVKLLGNILQWDGILSTSCLRDLALDSTLNRYILSALQTTDLCE DNVLKCQKVVECLPLHWFSGLKGQQTLPQLEPFCRYVTHLANSLHRSTLG VSDVERRTVKDQTKELVKMLGHMNALDHIVTVAAEH-------------- --G------------VKDIKQLLEAK-x >ENSPRNP00000035267 -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ---MF--------------------------------------------- ----------------------------------------KKAKRANFRR RNESDEEE-------HDE-------------------------------- -------------------------------------------------- -------xxx--------------------xx------------------ -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ------------xxx----------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------xxxx--------------- ----------------------------------------x--------- ---------------------xxxxx------------------------ -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -----x-------------------------------------------- -----------------------xxxx----------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -----------------------------------------------xxx xxxxxxxxxxxx-------------------------------------- -------xxxxxxxxxxxxxxxxxxxxxx--------------------- -------------------------------------------------- --xxxxxxxxKPS-----------------------------------LL SF-DDE--E-EG-------------------------------------- -----------------------------------------------S-- ------EVFRVKKSNHSKKIVKQLKKEYKE-------------------- --------------------------------DLEKSG------------ -----------------------xxxxxxxx------------------- -----------------xxxxxxxxxxxxxxx------------------ ------------------xxxx---------------------------- ----------------------------------SEQGEEEMEVDS---- ADEQExxxx----------------------------------------- --------------------xQG----AQAQ------------------- --------------SQVSx-xxxxxxxNTLSSLGSLRP-----------G EIPDAAFIHAARKRRQMARELGGDAPLTVTE-APKQRLVR-Ex---QDA- SD-DED-xxKRIRFSGVRNKSQRQKIAEE--I---GIEGSDDEALD-T-x QDEEVSRWEQEQIRKGISIPQVQSSQPEEN-TVYYQNSYESQPYGSTYSM PFTY--STVxxxxxxxxxxxxxxxxxxx-x-------------------- -------PLSDLSPVSIDLVKKRLQD-R---------------------- ------------------------------------------LSQMHAGH DANTRRYKQIKEDLAASESTIQQLEGSSNDNADQYKFLQEMRGYVGDLLE CFSEKVPAVLELEAAMHQLLRQRASRLVQRRQDDIKDESSEFASLS---- ---------------NKAVMAPSLDSFGRDRTAYLEHSRQRRIAERE--- ---ARR-TRR-RQAREQNGKRAEHNEGMSSDDEETSTDITSFDMEK--DR IIRECKKVFEDVVEDFHSLDCIKSHFEVWRHEYADCYRDAYIGLCLPKLF NPLVRLQLISWNPLD----------------------------------- -AQCANFEYMLWFESLLFYGFEENTx-LQRGDGDIGLLPAIVERVIVSKL TVLAEQVWDPLSDS--------------QTARLVSFIQRLMKSYPTVLHG DNRY-----TQELLKTIVLRTRRTLDEDVFLPLYPRSVLENKNSSPYLFY QRQFWSCIKLLGNILQWEGILSTSCLKDLALDSTLNRYILSALQTTDTEE DNVQKCQKVVECLPAHWFSGLKGQQTLPQLEPFCRYLVYVANSLHRSSLG RSDVERRTYKEQIREVVKMLGHMNALDHIIAVAEEH-------------- --G------------IKDIKPLLEVK-x >ENSMALP00000012092 -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ---MF--------------------------------------------- ----------------------------------------KKAKRVNLRR RNESDEEE-------LDE-------------------------------- -------------------------------------------------- -------xxx--------------------xx------------------ -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ------------xxx----------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------xxxx--------------- ----------------------------------------x--------- ---------------------xxxxx------------------------ -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -----x-------------------------------------------- -----------------------xxx------------------------ -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ---------------------------------------------xxxxx xxxxxxxxxxxx-------------------------------------- -------xxxxxxxxxxxxxxxxxxxxxx--------------------- -------------------------------------------------- --xxxxxxxxKVS-----------------------------------LL SF-DDE--E-EG-------------------------------------- -----------------------------------------------S-- ------EVFRVKKSNHSKKIVKQLKKEYKE-------------------- --------------------------------DLERSG------------ -----------------------xxxxxxxx------------------- -----------------xxxxxxxxxxxxxxx------------------ ------------------xxxx---------------------------- ----------------------------------SEHGEEEMEVDS---- ADEPExxxx----------------------------------------- --------------------xLG----VQAP------------------- --------------SQMSxxxxxxxxxNTLSSLGSLRP-----------G EIPDAAFIHAARKRRQMARELGGEAPLVEKE-GLTKRLVQ-Ex---QDV- SD-NEDEDEKRISFSGVQNKSQRQKIAEE--I---GIEGSDDEALD-T-x QDEEVSRWEQEQIRKGISIPQVQSSQPEGN-TVYYQNSYESQPYGSSYSM PFTY--SAVxxxxxxxxxxxxxxxxxxx-x-------------------- -------SISDLTPVSIDLVKKRLQD-R---------------------- ------------------------------------------LSQMCAGH NANAKRHKQIEEDLAASESAIQQLEGSSNDNADQYKFLQEMRGYVGDLLE CFSEKVPAVLELEAAMHQLLRQRASRLVQRRQDDIKDESSEFASLS---- ---------------NKAVMAPNLDSFGRDRTAYQEHSRQRRIAERE--- ---ARR-TRR-RQAREQNGKRADHKEGLSSDDEETSTDITSFNMEK--DR IIRESKKVFEDVLEDFHSLDCIKARFEVWRKDYADCYREAYIGLCLPRLF NPLIRLHLITWNPLE----------------------------------- -AQCTNFEYMLWFESMLFYGFEEHSx-LQKGDGDIGLLPAIVEKVIISKL TVLAEQVWDPLSGS--------------QTTRLVGFIYRLMKGYPTVMHG DNRY-----TQELLKAVVLRTRRTLDEDVFLPLYPKNVLENKNSSPYLFY QRQFWSCVKLLGNILQWDGILSTSCLKDLALDSTLNRYILSALQTTDTAE DNVPKCQKVVECLPVQWFSGLKGQQTLPHLEPFCRYLTHLASSLHRSSLG SADVERRSAKEQIKEIVKMLHHMNALDHIIAVAEEH-------------- --G------------VKDIKTLLEAK-x >ENSBSLP00000022036 x------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -xxMF--------------------------------------------- ----------------------------------------KKAKRVNLRR RNESDEDE-------LEE-------------------------------- -------------------------------------------------- -------xxx--------------------xxx----------------- -------------------------------------------------- ------------xxx----------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------x------------------------------------ -------------------------------------------------- ---------xxxxxx----------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------xxxx--------------- ----------------------------------------x--------- ---------------------xxxxx------------------------ -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -----x-------------------------------------------- -----------------------xxx------------------------ -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ---------------------------------------------xxxxx xxxxxxxxxxxx-------------------------------------- -------xxxxxxxxxxxxxxxxxxxxxx--------------------- -------------------------------------------------- --xxxxxxxxKSI-----------------------------------LL SF-DDE--E-EG-------------------------------------- -----------------------------------------------S-- ------EVFRVKKSNHSKKIVKQLKKEYKE-------------------- --------------------------------DLERTG------------ -----------------------xxxxxxxx------------------- -----------------xxxxxxxxxxxxxxx------------------ ------------------xxxx---------------------------- ----------------------------------SERGEEEMEVES---- ADEQExxxx----------------------------------------- --------------------xQG----GQAH------------------- --------------SQLSxxxxxxxxxNTLSSLGSLKP-----------G EIPDAAFIHAARKRRQMARELGGETPLVETE-TQKKRLVR-Ex---QDV- SD-DEDEEEKRIRFSGVKNKSQRQKIAEE--I---GIEGSDDEALD-T-x QDEEVSRWEQEQIRKGISIPQVQSTQPEDN-TMYYQNSYESQPYGSSYSM PFTY--STVxxxxxxxxxxxxxxxxxxx-x-------------------- -------PVSAPSPVSIDLVKKRLQD-R---------------------- ------------------------------------------LSQMHAGH NGNVKRYKQIEEDLAASESAIQQLEGSSNDNADQYKFLQEMRGYVGDLLE CFSEKVPAVLELEAAMHQLLRQRASRLVQRRQDDIKDESSEFASLS---- ---------------NKAVMAPNLDSFGRDRAAYQEHSRQRRIAERE--- ---ARR-TRR-RQAREQNGKRAEHKEGLSSDDEETSTDITSFNMEK--ER IARECKKVFEDVVEDFHSLDYIKSHFEVWRRDYADCYKDAYIALCLPKLL SPLVRLELITWNPLE----------------------------------- -AQCANFEYMLWFESLLFYGFEEHSx-LEKGDGDIGLLPAIVEKVILSKL TVLAEQVWDPLSSS--------------QTARLIGFIHRLIKGYPTVLHG DNQY-----TQELLKSVVLRTRRTLDEDIFLPLYPKSVLENKNSSPYLFY QRQFWSCVKLLGNILQWDGVLSTSCLKDLALDSTLNRYILSALQTTDTEE DNVQKCQKVVECLPSQWFSGLKGQQTLPQLEPLCRYLAHLANSLYRSSVG TSDMERRTAKEQVKDVVKMLRHLNGLDHIITVAAAH-------------- --G------------VKDVKLFLEAK-x >ENSMMOP00000001074 -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ---MF--------------------------------------------- ----------------------------------------KKAKRANFRR RNESDEEE-------Q-x-------------------------------- -------------------------------------------------- -------xxx--------------------xx------------------ -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ------------xxx----------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------xxxx--------------- ----------------------------------------x--------- ---------------------xxxxx------------------------ -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -----x-------------------------------------------- -----------------------xxx------------------------ -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ---------------------------------------------xxxxx xxxxxxxxxxxx-------------------------------------- -------xxxxxxxxxxxxxxxxxxxxxx--------------------- -------------------------------------------------- --xxxxxxxxKAS-----------------------------------LL SF-DDD--E-DE-------------------------------------- -----------------------------------------------S-- ------EVFRVRKSNHSKKIVKQLKKEYKE-------------------- --------------------------------DLEKSG------------ -----------------------xxxxxxxxx------------xx---- ------------------------xxxxxxxx------------------ ------------------xxxx---------------------------- ----------------------------------SDHGEEEMEVDS---- ADEQDxxxx----------------------------------------- --------------------xQG----GQTH------------------- --------------SQITxx-xxxxxxNTLSSLGSLRP-----------G EIPDAAFIHAARKRRQLARELGGDAPLVETE-APKKRLVG-Ex---QDA- SD-DEDDEEKRIRFSGVKSKSQRQKIAEE--I---GIEGSDDEALD-T-x HDEELSRWEQEQIRKGISIPQVQSSQSEDN-MVYYQNSYESQPYGSSYSV PFTY--STVxxxxxxxxxxxxxxxxxxxxx-------------------- -------TFSDLTPVSIDLVKKRLQD-R---------------------- ------------------------------------------LSLMHTSN NANTKRYKQIEDDLAASESTIQHLEGSSNDNAAQYKFLQEMRGYVGDLLE CFSEKVPDVLELEAAMHQLLRQRASRLVQRRQDDIKDESSEFASLS---- ---------------SKAVMAPNLDSFGRDRAAYQEHSRQRRIAERE--- ---ARR-TRR-RQAREQNGKRAEHKEGLSSDDEETSTDITSFNMER--DR IIKECKKVFEDVVEDFHSLDCIKSHFEVWRREYADSYRDAYIGLCLPKLF NPLVRLQLITWNPLE----------------------------------- -GECANFEYMLWFESLLFYGFEENSx-LQGGDGDVSLLPSIVEKVILSKL TVLAEQVWDPLSSS--------------QTASLVNFIHRLMKGYPTVLHG DNQY-----TQELLKTIVLRTRRTLDEDVFLPLYPKNVLENKNSGPYLFY QRQFWSCVKLLGNILQWENILSISCLRDLALDSTLNRYILSALQTADTGE ENVLRCQKVVEYLPSQWFSGLKGQQTLPQLEPFCRYLAHLANSLYRSSVG TSDVEx----DLVKEAVKMLGHMNALDHIIAVAAEQ-------------- --G------------IKDIKLLLEAK-x >ENSGACP00000027247 -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ---MF--------------------------------------------- ----------------------------------------KKAKRANFRR RNASDEED-------QEE-------------------------------- -------------------------------------------------- -------xxx--------------------xxx----xx----------- -------------------------------------------------- ----------xxx------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ---------------------------------xx--------------- ----------------------------------------x--------- ---------------------xxxxx------------------------ -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -----x-------------------------------------------- -----------------------xxx--xxx------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------x--x--------------------- -------------xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx xxxxxx-------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------xxxKAS-----------------------------------LL SF-DDD--E-EE-------------------------------------- -----------------------------------------------S-- ------EVFRVKKSNHSKKIVKQLKKEYKE-------------------- --------------------------------DLEKSG------------ ------------------------xxxxxxx------------------- -----------------xxxxxxxxxxxxxxx------------------ ------------------xxxx---------------------------- ----------------------------------SDHGEEEMEVDS---- TEEEE--------------------------------------------- -------------------------------------------------- -------------------xxxxxxxxNTLSSLSSLRP-----------G EIPDAAFIHAARKRRQLAREQGGEAPLIETD-TPKKRMVRxxx---QDA- SD-DEDEEEKRIRFSGVKNLSQRQKIAEE--I---GIEGSDDEALD-T-x QDEEVSRWEQEQIRKGISIPQVQSIQPEDN-TVYYQNSYESQPYGSAYCM PFTY--STAxxxxxxxxxxxxxxxxxxx-x-------------------- -------PIGDLTPVSIDLVKKRLQD-R---------------------- ------------------------------------------LGQMRAGH NANAGRYKQIEEDLAASESAILQLEASSNDDADQYKFLQEMRGYVGDLLE CFSEKVPAVLELEAAMHQLLRQRASRLVQRRQDDIKDESSEFASLS---- ---------------SKAVMAPNLDSFGRDRAAYQENSRQRRIAERE--- ---ARR-TRR-RQAREQNGKRAEHKEGLSSDDEETSTDITSFNTER--DR IVRECKKVFEDVVEDFHSLDCIKSHFEVWRREYADCYRDAYIGLCLPKLF NPLVRLQLITWNPLE----------------------------------- -TPCANFEYMLWFESLLFYGFEEHSx-LQRGDGDIGLLPAIVEKVILSKL TVLAEQVWDPLSDS--------------QTAGLVGFIHRLMKGYPTVLHG DNRY-----TQELLRTIVFRTRRTLDEDVFLPLYPKNVLENKNSGPYLFY QRQFWSCVKLLDNILQWEGILSSSCLKDLALDSTVNRYILSALQSTDTGA DNVPKCQKVVQCLPVHWFSGLKGQHTLPQLEPFCRYLTHLASSLYRGSLG GSDVERRTAKDQVKEVVKLLGNMNALNHIIAVAAEH-------------- --G------------IKDIKPFLEAK-x >ENSCGOP00000020719 -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ---x---------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ----------------------------xxxxxxxxxxxxxxxxxxxxxx xxxxxxxxxxxxxxxx---------------------------------- -------------------------------------------------- -------------------------------------------------- ---xxxxxxxxx-------------------------------------- -------xxxxxx--xxxxxxxxxxxxxxx-------------------- -------------------------------------------------x xxxxxxxxxxKAS-----------------------------------LL SF-DDD--E-EG-------------------------------------- -----------------------------------------------S-- ------EVFRVKKSNHSKKIVKQLKKEYKE-------------------- --------------------------------DLEKSG------------ ------------------------xxxxxxx------------------- -----------------xxxxxxxxxxxxxxx------------------ ------------------xxxx---------------------------- ----------------------------------SDQGEEEMEVDS---- ADDQQxxxx----------------------------------------- --------------------xQG----GHPQ------------------- --------------GQVSxxxxxxxxxNTLSSLGSLKP-----------G EIPDAAFIHAARKRRQLARELGGEAPLVETE-TPKKRMAQ-Ex---QDA- SD-DEDEDEKRIRFSGVKNKSQRQKIAEE--I---GIEGSDDEALD-T-x QDEEVIRWEQEQIRKGISIPQVQSSQPEDN-TVYYQNSYETQPYGSSYSM PFTY--STVxxxxxxxxxxxxxxxxxxx-x-------------------- -------PISDLTPVSIDLVKKRLQD-R---------------------- ------------------------------------------LSQMSAGH DANARRYKQIEEDLAASESAIQQLEGSSNNNSDQYKFLQEMRGYVGDLLE CFSEKVPAVLELEAAMHQLLRQRASRLVQRRQDDIKDESSEFASLS---- ---------------NKAVMAPNLDSFGRDRAAYTENSRQRRIAERE--- ---ARR-TRR-RQAREQNGKRAEHKEGLSSDDEETSTDITSFNMEK--DR IIRECKKVFEDVVEDFHSLDCIKSHFEVWRKEYADCYRDAYIGLCLPKLF NPLVRLQLITWNPLE----------------------------------- -SQCANFEYMLWFESLLFYGFEEHSx-LQRGDGDSSLLPAIVEKVILSKL TVLAEQVWDPLSNS--------------QTARLVGFIHRLMKGYPTVLHG ENRY-----TQELLKTIVFRARRTLDEDVFLPLYPKNVLENKNSGPYLFY QRQFWSCVKLLGNILQWEGILSSSCLRDLALDSTLNRYILCALQTTDTGE DNVPKCQKVVECLPVQWFSGLKGQQTLPQLEPFCRYLTHLANSFNRSSLG GSDLERRSAKDLIKEVVKMLGQMNALDHIITVAAEH-------------- --G------------IKDIKPLLEAK-x >ENSGWIP00000006562 -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ---MF--------------------------------------------- ----------------------------------------KKAKRANFRR RNESDEEE-------QE--------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------xxx---------------------------- xxxxxxx------------------------------------------- -------------------------------------------------- -------xxxxxxxxxxxxxxxxxxxxxxxxx------------------ --------------------------------------------xxx--- --------xxKAS-----------------------------------LL SF-EDD--E-DD-------------------------------------- -----------------------------------------------S-- ------EVFRVKKSNHSKKIVKQLKKEYKE-------------------- --------------------------------EVEK-------------- -------------------------------------------------- --------------xx---xxxxxxxxxxxxx------------------ ------------------xxxx---------------------------- ----------------------------------SKHGEEEMEVES---- ADEPExxxx----------------------------------------- -------------------------------------------------- ------------------------xxxNTLSSLSTLRP-----------G EIPDAAFIHAARKRRQLARELGGEAPLVETE-TPKKRLVQ-Ex---QDA- SD-D-xxxxKRISFSGVRNKTQRQKIAEE--I---GIEGSDDEALD-T-x HDEEVSRWEQEQIRKGISIPQVQSSQPEEN-TVYYQNSYETQPYGSSYSM PFTY--SSMxxxxxxxxxxxxxxxxxxx-x-------------------- -------PVSELTTVSIDLVKKRLQV-R---------------------- ------------------------------------------LGEMNAGY EANSKRYEQIKEDLAASESSIEQLEGSSNENADQYKFLQEMRGYVGDLLE CFSEKVPAVLELEAAMHQLLRQRATRLVQRRQDDIKDESSEFASLS---- ---------------NKAVMAPSLDSFGRDRATYQEHSRQRRIAERE--- ---ARR-TRR-RQAREQNGKRAEHNEGLSSDDEETSTDITAFNMEK--DR IIKESKKVFEDVVEDFHSLDCIKRHFEDWRRDYVDCYRNAYIDLCLPKLF NPLVRLQLITWNPME----------------------------------- -DQCANFEYMLWFESLLFYGFDEHSx-LKKGDADIGLLPAIVEKVILSKL TVLAEQVWDPLSNS--------------QTSRLVAFIIRLMKGYPTVMHG DNRY-----TQELLKAIVLRTRRTLDEDIFLPLYPKSVQDNKNSGPYLFY QRQFWTCIKLLRNILLWEGILSASCLKDLAFDSTLNRYILSALQTTDTIE ENLLKCQKVVECLPEHWFSGLKGQQTLPQLEPLCRYITHLANLLHRSSLG ASDVxx----HQVKEALKMLGRMNALDHIIAMATEH-------------- --G------------MKDIKPLLELK-x >ENSCSEP00000014574 -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ---MF--------------------------------------------- ----------------------------------------KKAKRANIRR RNESDEDE-------QEE-------------------------------- -------------------------------------------------- -------xxx--------------------xx------------------ -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ------------xxx----------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------xxxx--------------- ----------------------------------------x--------- ---------------------xxxxx------------------------ -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -----x-------------------------------------------- -----------------------xxx------------------------ -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ---------------------------------------------xxxx- ----------------------xxx---------xxxx------------ ---xxxxxxxxxxxxxxxxxxxxxxxxxxxxxx----------------- --------------------------------------------x----- -------xxxKGS-----------------------------------LL SFxxxx--E-EG-------------------------------------- -----------------------------------------------L-- ------EVFKVKKSTHSKKIVKQLKREYKE-------------------- --------------------------------DLEKTE------------ -----------------------xxxxxxxx------------------- -----------------xxxxxxxxxxxxxxx------------------ ------------------xxxx---------------------------- ----------------------------------SDQGEEEMEVDS---- NDEQNxxxx----------------------------------------- --------------------xQA----GQAQ------------------- --------------SQMSxxxxxxxxxNTLSSLGNLRP-----------G EIPDAAFIHAARKRRQLARELGGDAPLVEAE-APKKRHAS-Ex---QDV- SD-DEDEAEKRIRFSGVKKKSQRQKIAEE--I---GIEGSDDEALD-T-x QDEEVTRWEQEQIRKGISIPQVQTTQPEDT-TIYYQNSYESQPYGASYSM PFTY--STVxxxxxxxxxxxxxxxxxxx-x-------------------- -------QITDLPPVSIDLVKKRLQD-R---------------------- ------------------------------------------LSHMRAGH QANSKHFRQIDDDLASSENSIQQLEGSSNDNEEKYKFLQEMRGYVGDLLE CFSEKVPAILELEAAMHQLLRQRTSRLVQRRQDDIKDESSEFASLS---- ---------------NKAVMAPNLDSFGRDRAAYQEHSRQRRIAERE--- ---ARR-TRR-RQAREQNGKRAEHKEGLSSDDEETSTDITSFNMEK--ER ISRECKKVFEDVVDDFHSLDFIKSRFEVWRRDFPDSYRDAYIGLCLPKLF SPLVRLQLITWSPLE----------------------------------- -AQCANFEYMLWFESLLFYGFEENIx-LQKDDGDIGLLPAIVEKVILSKL KVLVEQAWDPLSTN--------------QTARLVSFIRRLLKGYPTVLHG DNQY-----TQELLKSIVLRTRRTLDEDVFLPLYPKNVLDNKNSGPYLFY QRQFWSCVKLLGNILQWDGILSTSCLKDLALDSTLNRYILSALQTTDTAE ENVHKCQKVVEVLPQHWFLGMKAQQTLPQLEPLCRYLGHLANTLHRSSVS GSDLERHSVKDQVKEVVRMLGYMKALDHIMSVAAEF-------------- --G------------FKDIKPLLEAL-x >ENSTNIP00000012857 -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ---MF--------------------------------------------- ----------------------------------------KKAKRANIRR RNESDEEE-------QDE-------------------------------- -------------------------------------------------- -------xxx--------------------xx------------------ -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ------------xxx----------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------xxxx--------------- ----------------------------------------x--------- ---------------------xxxxx------------------------ -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -----x-------------------------------------------- -----------------------xxx------------------------ -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ---------------------------------------------xxxxx xxx----------------------------------xxxxxxxxxxxxx xxxx-------------xxxxxxxxxxxx--------------------- -------------------------------------------------- --xxxxxxxxKAS-----------------------------------LL SF-DDD--xxEG-------------------------------------- -----------------------------------------------S-- ------EVFRVKKSNHSKKIVKQLKREYKE-------------------- --------------------------------DLEKSG------------ -----------------------xxxxxxxx--------------xxxxx xxxxxxxxxxxxx------------------------------------- ---------------------x---------------------------- ----------------------------------SDHGEEEMEVDS---- ADEQD--------------------------------------------- --------------------------------xx---------------- ------xxx---------------xxxNTLSSLSSLRP-----------G EIPDAAFIHAARKRRQLARELGGDAPLVETE-APNKHLVx-Ex---QDA- SD-DED--xKRIRFSGVKNKTQRQKIAEE--I---GIEGSDDEALD-T-x QDEEVSRWEQEQIRKGISIPQVQSSQPEDN-MVYYQNSYEGQPYGTSYSM PLTY--SSVxxxxxxxxxxxxxxxxxxx-x-------------------- -------AISDLNPVSVDLVKKRLQD-R---------------------- ------------------------------------------LAHMYAGH NANTKHYKQIGEDLAASESTIKQLEGSSTDKADQYKFLQEMRGYVGDLLE CFSEKVPAVLELEAAMHQLLRQRASRLVQRRQDDIKDESSEFASLS---- ---------------SKAVMAPNLDTFGRDRAAYQEQRRQRRIAERE--- ---ARR-TRR-RQAREQNGKRAEHNEGFSSDDEETSTDITSFNAER--DR IVNESKKVFEDVLEDFHSLDYIKCHFEVWRRDYAECYREAYIGLCLPKLF NPLVRLQLITWNPLE----------------------------------- -GECDNFEYMLWFESLLFYGFDEHAx-LQKGDGDNGLLPSIVEKVILSKL AALAEQVWDPLSRS--------------QTARLVEFLHRLRKGYPTVLHG DNKY-----TQELLKTIVLRTRRTLDEDIFLPLYPKSVLDNKNGSPYLFY QRQFWSCAKLLGNILMWEGILSISCLKDLALDSTLNRYILSALQTTDAGE ENVHRCQKVVECLPPLWFSGLKGQQTLPQLEPLCRYLVHLANSLHRSSLG TSDLERRTTKDLIREVVKMLVHMKALDHIISLAAEQ-------------- --G------------IKDIKQLLEA--- >ENSTRUP00000003355 -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ---MF--------------------------------------------- ----------------------------------------KKAKRANIRR RNESDEDE-------QDE-------------------------------- -------------------------------------------------- -------xxx--------------------xx------------------ -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ------------xxx----------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------xxxx--------------- ----------------------------------------x--------- ---------------------xxxxx------------------------ -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -----x-------------------------------------------- -----------------------xxx------------------------ -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ---------------------------------------------xxxxx xxx----------------------------------xxxxxxxxxxxxx xxxx-------------xxxxxxxxxxxx--------------------- -------------------------------------------------- --xxxxxxxxKAS-----------------------------------LL SF-DDD--E-EG-------------------------------------- -----------------------------------------------S-- ------EVFRVKKSNHSKKIVKQLKREYKE-------------------- --------------------------------DLEKSG------------ -----------------------xxxxxxxx--------------xxxxx xxxxxxxxxxxxx------------------------------------- ---------------------x---------------------------- ----------------------------------SDHGEEEMEVDS---- TDEQE--------------------------------------------- --------------------------------xxxxxxxxx--------- -----xxxx---------------xxxNTLSSLSSLRP-----------G EIPDAAFIHAARKRRQLARELGGDAPLVETE-VSNKHLVx-Ex---QDA- SD-DED--xKRISFSGVKNKTQRQKIAEE--I---GIEGSDDEALD-T-x QDEEVSRWEQEQIRKGISIPQVQSSQPEDN-MVYYQNSYESQPYGTSYSM LLTY--NSVxxxxxxxxxxxxxxxxxxx-x-------------------- -------AVSDLSPVSIDLVKKRLQD-R---------------------- ------------------------------------------LGHMYAGH NANTEHYKQIEEDLAASEGSIQQLEGSSTDKADQYKFLQEMRGYVGDLLE CFSEKVPAVLELEAAMHQLLRQRASRLVQRRQDDIKDESSEFASLS---- ---------------NKAVMAPNLDTFGRDRAAYQEQRRQRRIAERE--- ---ARR-TRR-RQAREQNGKRAEHNEGFSSDDEETSTDITSFSMEK--ER IVTEAKKVFEDVVEDFHSLDYIKSHFEVWRRDYAECYREAFIGLCLPKLF NPLVRLQLMTWNPLE----------------------------------- -VECENFEYMLWFESLLFYGFDEQTx-LQKGDGDNGLLPSIVEKVILSKL TVLVEQVWDPLSRS--------------QTALLVEFLHRLRKGYPTVLHG DNKY-----TQELLKTIVLRTRRTLDEDIFLPLYPKSVLDNKNSGAYLFY QRQFWSCVKLLGNILMWDGILSLSCLKDLALDSTLNRYILSALQTTDVGE DNVQKCQKVVECLPVPWFSGLKGQRTLPQLEPLCRYLAHVANSLHRSSLG VSDLERRTARDLIREAVKMLVHMKALDHIISVAAEQ-------------- --G------------IKDIKQLLEI--- >ENSHCOP00000026936 -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ---MF--------------------------------------------- ----------------------------------------KRIKRANFRR RNESDEDE-------REE-------------------------------- -------------------------------------------------- -------xxx--------------------xx------------------ -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ------------xxx----------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------xxxx--------------- ----------------------------------------x--------- ---------------------xxxxx------------------------ -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -----x-------------------------------------------- -----------------------xxx------------------------ -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ---------------------------------------------xx--- ------------------------xxxxxxxxxxx--------------- -------xxxx---------------------xxxx-------------- -----------------------------xxxxxxxxxxxxxxxx----- -------xxxKAS-----------------------------------LL SF-DxxxxE-EG-------------------------------------- -----------------------------------------------P-- ------EVFRVKKSNHSKKIVKQLKKEYKE-------------------- --------------------------------DLEKCG------------ -----------------------xxx------------------------ ----------------xxxxxxxxxxxxxxxx------------------ ------------------xxxx---------------------------- ----------------------------------SEHGGDEMEVDS---- ADEQRxxxx----------------------------------------- ---------------------------------------xxxxxxx---- -------------------xxxxxxxxNTLSSLNTLRP-----------G EIPDAAFIHAARKRRQLARELGGDAPLVETE-APKKRMAQ-Ex---QDG- SD-DEDEEEKRIRFSGVRSKTQRQKIAEE--I---GIEGSDDEALD-T-x HDEEVSRWEQEQIRKGISIPQVQSSQPEDT-AAYYQNSYDTQPYGTGYNM PFTY--SVVxxxxxxxx--xxxxxxxxx-x-------------------- -------SVSDLAPVSIDLVKKRLRD-R---------------------- ------------------------------------------LGHMRTGH NANINRYTQIQEDLAASESAIMQLDGSSNDNADQYQFLQEMRGYVGDLLE CFGEKVPAIEELEAAMHQLLRQRASRLVQRRQDDIKDESAEFASLS---- ---------------NKAVMAPSLDSFVRDRTLYQESSRQRRIAERE--- ---ARR-ARR-RQAREQNGKWAEHKEGLSSDDEETSTDITSFSVEH--DR ITRECQKVFEDVLEDFHSMDYIKSQFEAWRRNYAECYKDAYIGLCLPKLF SPLIRLQLITWNPLE----------------------------------- -AQCTNFEYMLWFETLLFYGFEEHSx-LQKGDSDIGLLPAIVEKVVLTKL TVLSEQVWDPLSNS--------------QTARLVGFIRRLMKGYPTVLHG DNQF-----TRELLRTVVLRVRRTLDEDVFQPLYPKNLLENKNGGPYLFY QRQFWSCVKLLGNILQWEGIISTSCLKDLALDSTLNRYILSALQTTEASE DNVHKSQKVVDCLPMQWFNGLKGQQTLPQLEPLCRYLVHLANSLNRSSLG ASDVERRVTKDQVKEIVKMLVYMKAVDHIIAVAAEQ-------------- --G------------IKDIKSLLETK-x >ENSPKIP00000005039 -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ---MF--------------------------------------------- ----------------------------------------KKAKRVNFRR RNESDD-------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ----xx--x-xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxT-- ------EVFRVKKPNHSKKIVKQLKKEYKE-------------------- --------------------------------DLEKNS------------ -----------------------xxxxxxxxxxxx---xxxx-------- ------------------------------------xxx----------- --------xxxxxxxxxxxxxx---------------------------- ----------------------------------SEQGEEEMEVDS---- NEExxxx------------------------------------------- ------xxxxxxx-GAAFS------------------------------- ---------------------------NTLSSLSTLRP-----------G EIPDAAFIHAARKRRQLARELGADGPAPEPE-GGKKRLVR-ED--EHDG- S--xxxxxxKRIVFSGVKMKTQRQKIAEE--I---GIEGSDDEALD-TAG NDEEVSRWEQEQIRKGISIPQVQTNPPEDA-NMYYQSGYDVQPYGTSYSL TYSY--NSV-----------------------------AGD-DSKx-KAD TSVTFSAPSSDLTPITTDLVKKRLKD-R---------------------- ------------------------------------------LSSVRQGH SSNAKRYEQIQEELASSARTIQRLEGSSDAVADQYKFLQEMRGYVRDLLE CFGEKVPVILELEAAMHQLLMQRASRLVQRRQDDIKDESAEFSSLS---- ---------------NKALMAPNLDSFGRDRAAYQEHAKQRRIAERE--- ---ARR-TRR-RQAREQNGKRAAHREGLSSDDEETSTDITSFNLER--ER ILKDSKKVFEDVLEDFQSLDGIKSRFEVWRKLYSACYQDAYIGLCLPKLF SPLVRLQLIGWFPLE----------------------------------- -VDCPNFEYMLWFESLLFYNCEEQSx-MQKDDVDVGLLPAIVEKVILPKL AVLVDQVWDPLSSN--------------QTSRLVAFMQRLIKGYPTVLHG DNRN-----TQELLKTIVLRTRRTLDNDIFMPLFPKNILENKNSGPYLFF QRQFWSCVKLLENILQWYGILSNCTLRELAVDSTLNRYILSALQSTDPGE ESIDKSRSVVECFPQQWFSSLKGQQTIPQLENFCRYLKHVASTVYRISLA GSDMERRNAREQIKEVVKLLGRINALDHVVAVATEH-------------- --G------------IKDIKTLLESK-- >ENSSFOP00015010256 -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ---MF--------------------------------------------- ----------------------------------------KKAKRVNFRR RNDSDDEE-------QED-------------------------------- -------------------------------------------------- -------xx----------------------------------------- -------------------------------------------------- ------------x------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -----------------------------------xxx------------ --------xxxxxxxxxx-------------------------------- -------------------------------------------------- --------------------------------------------x----- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- --------------------xxxxxxxx---xxxxxxx------------ -----------------xxxxxxxxx--xP-------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ----------KAS-----------------------------------LL SF-QDE--E-ED-------------------------------------- -----------------------------------------------T-- ------EVFRVKKPNHSKKIVKQLKKEYKE-------------------- --------------------------------DLEKSN------------ -----------------------xxxxxxxxxxxxxxxxxxx-------- -------------------------------------------------- ----------xxxxxxxxxxxx---------------------------- ----------------------------------SEQGEEEMEVDS---- NDDxxxx------------------------------------------- ------xxxxxxx-GGSFS------------------------------- ---------------------------NTLSSLSVLRP-----------G EIPDAAFIHAARKRRQLARELGGDLPPPEME-VGKKRLVR-ED--EQGG- S--xxxxxxKRIVFSGVRQKTQRQKIAEE--I---GIEGSDDEALD-AAG HDEELSRWEQEQIRKGISIPQVQTNQPEET-NMYYQNSYEVQPYASSYGL PYSY--SSV-----------------------------GGD-DSKx-KSD SSVTYCAPSSDLTPITTDLVKKRLTD-R---------------------- ------------------------------------------LSTVRQVH CSNAKRYGQIQEELEASVRTIQRLEGSSDAVADQYKFLQEMRGYVRDLLE CFSEKVPLILELEAAMHQLLRQRASRLVQRRQDDIKDESAEFSSLS---- ---------------SKALMAPNLDSFGRDRGAYLEHAKQRRIAERE--- ---ARR-TRR-RQAREQNGKRAEHHEGLSSDDEETSTDITSYNLER--ER ILKESKKVFEDVLEDFHSLDTIKVHFEEWRRLYSACYQDAYIGLCLPKLF TPLVRLELMDWSPLE----------------------------------- -VDCRNFEYMLWFESLLFYGCEDQSx-MQKGDVDVGLLPAIVERVIIPKL AVLADQVWDPLSSS--------------QTARLVAFVHRLIKGYPTVLHG RNRN-----TQELLKTIVFRTRRTLDNDIFMPLYPKNALENKNSGPYLFF QRQFWSCVKLLGNILQWHGILSDATLRELAVDSTLNRYILSALQNTEPGE DSIEKSCSVVECFPQQWFSNLKGQQTIPQLENFCRYLKHVASTVYRISLA GSDVERRNAREQIKEVVKLLGRINALDHVIAIATEH-------------- --G------------IKDIKTLLENK-- >ENSLOCP00000010922 -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ---MF--------------------------------------------- ----------------------------------------KKAKRVNFRR RNESDDEE-------NEE-------------------------------- -------------------------------------------------- -------xx----------------------------------------- -------------------------------------------------- -----------xx------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -----------------------------------x-------------- -----------------xxxx------------------------xxxxx -------------------------------------------------- -----------------xxxxxxxxxxxxxxxxxxxxxxxxxxxx----- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- --------------------xxxxxxxxxxxx----xx------------ -----------------xxxxxxxxx--xP-------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ----------KAS-----------------------------------LL SF-HDE--E-DD-------------------------------------- -----------------------------------------------T-- ------EVFKVKKSNHSKKIVKQLKKEYKE-------------------- --------------------------------DLERTG------------ -----------------------xxxxx---------------------- -------------------------------------------------- ---------------------xxxxxxxxxxxxxxxxxxxxxxxxxx--- ---------------------------------CSEQGEEEMEVDS---- NEESExxxx----------------------------------------- ---xxx--------GGAFS------------------------------- ---------------------------SALSSLSTLRP-----------G EIPDAAFIHAARKRRQLAREL-xxxxxMESE-VGKNRLVR-ED--EHDA- SD-DEDDDEKRRIVFSVREKTQRQKIAEE--I--xGIEGSDDEALD-AGG QDEELSRWEQEQIRKGISIPQVQASQPEDV-TMYYQSSYEASSYGSSYGL PYTY--SSV-----------------------------GSE-DSKQLKSE SSVTYSAPSSEMTPITTDLVKKRLKDxR---------------------- ------------------------------------------LNSMREVH SSNKKRYEKIQQELESSTNMIERLEGSSDGVADQYKFLQEMRGYVRDLLE CFSEKVPLILELESAMHQLLRQRAARLVQRRQDDIKDESSEFASHS---- ---------------SKALMAPNLDSFGRDRGAYQEHAKQRRIAERE--- ---ARR-ARR-RQAREQNGKRAEHCEGLSSDDEETTTDITSFNLEK--ER ILKESKKVFEDVLEDFHSLDCIKARFEVWRRLYFKCYQDAYIGLCLAKLF SPLVRLQLISWSPLE----------------------------------- -ANCPNFEYMLWFEALLFYGCEEQSx-LPKGDVDINLLPSIVERVILPKL AVLADQVWDPFSTN--------------QTTRLVVFMHKLIKGYPTVLHG ENRN-----TQELLKTIVMRTRRTLDNDVFMPLYPKNVLENKNSGPYLFF QRQFWSCVKLLGNILQWHGVLSNTSLRELAVDSMLNRYILSALQSTDPGE DSIEKTQSVISCFPKQWFTSLKGQQTLPQLENVCRYLKHVANTVYRLSLG GSDVDKRNARDHIKEVVKLLGSINALDHAMAVSTEH-------------- --G------------IKDFKALLDGK-- >ENSAMXP00005055986 -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ---MF--------------------------------------------- ----------------------------------------KKARRCNFRR RNDSEDEE-------KDEx------------------------------- -------------------------------------------------- --------x----------------------------------------- -------------------------------------------------- -----------xx------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -----------------------------------------xxxxxxxxx xxxxxxxxxxx-----------------------------------xxxx -------------------------------------------------- -------------------------------------------------- -------xx----------------------------------------- ----------------xxx------------------------------- -------------------------------------------------- --------xxxxxxxxxxxxxxxxxxxx---xxxxxxx------------ -----------------xxxxxxxxx--xP-------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ----------KAS-----------------------------------LL SF-NDE--E-EE-------------------------------------- -----------------------------------------------T-- ------EVFRVKKSNHSKKIVKQLKKEYRExx------------------ ------xxxxxxxxxxxxxxxxxxxxxxxxxxx----------------- -------------------------------------------------- -------------------------------------------------- ------------------xxxx---------------------------- ----------------------------------SEQGEGEMEVDS---- NDEPExx------------------------------------------- ------xxxxxxx-GGAFS------------------------------- ---------------------------ETLSALSSLRP-----------G EIPDAAFIHAARKRRQMARELGGDAPLVEAE-VANKRLVH-ED--EQGG- S---xxxxxKRIVFSGVKQKSQRQKIAEE--I---GIEGSDDEALD-TEG NDEEVSRWEQEQIRKGISIPQVQTSQPEDA-NMYYQAGYEGQPYGVSYNM PYGY--AAV-----------------------------xxx-xSKPVKAE GPVPYPIPSSSLTPITTALVKKRLTD-R---------------------- ------------------------------------------LSSMRQGR DASARRYEQIQEELQASNSSILQLEDSSQHTAEQYKFLQEMRGYVRDLLE CFSEKVPAVLELEAAMHQLLRQRAARRVQRRQDDIKDESAEFSSLS---- ---------------NKAVMAPNLDPFGRDRAAYQELGKQRRVAERE--- ---ARR-TRR-RQAREQSGKRAEHKEGLSSDDEETSTDINSFNLER--DR VLKESKKVFEDVVEDFHSLDCIKSRFEVWRKLYFTCYRDAYIGLCLPKLF NPLIRLQLIPWSPLE----------------------------------- -DECPNFEYMLWFESLLFYGCEELTx-TREEDIDIGLLPAIVERVVLPKL AVLAEQVWDPLSRR--------------ETSRLVAFMMRLIKGYPTVLHG ENRN-----TQELLRTVVMRIRRSLDEDIFMPLFPKNVLENKNSGPYLFS QRQFWTCVKLLGNILQWDGILSQSTLKELAVDSTLNRYILSALQMADFGE DSVEKCRRVVEYFPVHWFSTLKGQQTLPQMENLCRYMKHLATSLYRSSLT ASDVDKRNVREHIKEVVRLLGRLNALDHVITVASEH-------------- --G------------IKDIKTLLETK-- >ENSPNAP00000019060 -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ---MF--------------------------------------------- ----------------------------------------KKARRCNFRR RNESEDEE-------KDExxxx---------------------------- ----------------xxxxxxxxxxxxxxxxxxxx-------------- -xxxxxxx------------------------------------------ -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- --------------xxxxxxxxxxxxxx---xxxxxxx------------ -----------------xxxxxxxxx--xP-------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ----------KAS-----------------------------------LL SF-NDD--E-ED-------------------------------------- -----------------------------------------------T-- ------EVFRVKKSNHSKKIVKQLKKEYRExxx---------------xx xxxxxx--------------------xxxxxxx----------------- -------------------------------------------------- -------------------------------------------------- ------------------xxxx---------------------------- ----------------------------------SEQGEGEMEVDS---- NDEQDxx------------------------------------------- ------xxxxxxx-GGAFS------------------------------- ---------------------------QTLSALSSLRP-----------G EIPDAAFIHAARKRRQMARELGGETPLVDME-VANKRLVR-ED--EQGG- S----xxxxKRIVFSGVTQKSQRQKIAEE--I---GIEGSDDEALD-TAG NDEEVSRWEQEQIRKGISIPQVQTSQPEDT-NMYYQGGYEGQPYGVSYGM PYGY--AAV-----------------------------xxx-xSKPVKAE SSVPYPIPSSSLTPITTALVKKRLTD-R---------------------- ------------------------------------------LSSMRQGR DASAQRYEQIQEELQASNSSILQLEESSQHTAEQYKFLQEMRGYVRDLLE CFSEKVPAVLELEAAMHQLLRQRAVRRVQRRQDDIKDESAEFSSLS---- ---------------SKAVMAPNLDPFGRDRAAYQELSKQRRIAERE--- ---ARR-SRLxVQAREQSGKRAEHKEGLSSDDEETSTDITSFNLEK--DR ILKESKKVFEDVIEDFHSLDCIKSRFEVWRKLYFTCYRDAYIGLCLPKLF NPLIRLQLIPWSPLE----------------------------------- -DDCPNFEYMLWFESLLFYGCEEQTx-TQEEDIDTGLLPAIIERVILPKL AVLSDQVWDPLSRS--------------ETCRLVAFMRRLIKGYPTVLHG ENRN-----TQELLRTIVIRTRRSLDEDVFMPLFPKNVMENKNSGPYLFS QRQFWSCVKLLGNVLQWDGILSQNTLKELAIDSTLNRYILSALQMADVGE DSVEKCQQVVECFPVHWFSTLKGQQTLPELENLCRYMKHLASSLYRSSLT ASDVDKRSAREHIKEVVKVLGRLNALDHVIAVASEH-------------- --G------------IKDIKTLLESK-- >ENSIPUP00000005791 -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ---MF--------------------------------------------- ----------------------------------------KKAKRCNFRR RNDSDDDE-------KDEx------------------------------- -------------------------------------------------- --------x----------------------------------------- -------------------------------------------------- -----------xxxxxxx-------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------xxxxx-------- ------------xx------------------------------------ -------------------------------------------------- ---------x---------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ----------------------------------x--------------- ----------------------------------------x--------- ---------------------xx--------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ----------------------------xxxxxxxxxxxxxx-------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ---------------xxxxxxxxxxxxx---xxxxxxx------------ -----------------xxxxxxxxx--xP-------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ----------KAS-----------------------------------LL SF-NDE--E-ED-------------------------------------- -----------------------------------------------T-- ------EVFRVKKSNHSKKIVKQLKKEYRExxxxxxxxxxxxxxxxxxx- --------------------------------x----------------- -------------------------------------------------- -------------------------------------------------- ------------------xxxx---------------------------- ----------------------------------SEQGEGEMEVDS---- NDEQDxx------------------------------------------- ------xxxxx---GGNFS------------------------------- ---------------------------QTLSALSSLRP-----------G EIPDAAFIHAARKRRQMARELGGEAPLVETD-ASSKRLVR-ED--EQGG- S---xxxxxKRIVFSGVKQKSQRQKIAEE--I---GIECSDDEALN-TEG HDEEVSRWEQEQIRKGISIPQVQTSQPEDA-NMYYQTGYENQQYATSYSM PYGY--TAL-----------------------------xxx-xVKPVKAE NTVPYPIPSSSLTPITTALVKKRLMD-R---------------------- ------------------------------------------LSSMRQGR DASARRYEQIQEELQASDNSILQLEDSSQHAAEQYKFLQEMRGYVRDLLE CFSEKVPAVLELEAAMHQLLRQRAMRRVQRRQDDIKDESAEFSSLS---- ---------------SKAVMAPNLDPFGRDRAAYQELSRQRRVAERE--- ---ARR-ARR-RQAREQSGSRAEHKEGLSSDDEETSTDATSFNLER--DR ILKESKKVFEDVIDDFHSLDCIKSRFEVWKNLYFTCYRDAYIGLCLPKLF NPLIRLQLIPWSPLE----------------------------------- -EDCPNFEYMLWFETLLFYGYEEQSx-EHLEDIDSGLLPAIVERVVLPKL AVLAEQVWDPLSHS--------------ETCRLVAFMQRIIKGYPTILHG ENRN-----TQELLRTILVRTRRTLDEDVFMPLYPKNVMENKNSSPYLFF QRQFWSCVKLLGNILQWDGILSHNSLKELAVDSTLNRYILSALQSTDVGE DSVEKCRKVVECFPLHWFSSLKGQQTLPQLENLCRYLKHMASSLYRSSLT ASDVDKRIAREHIKEVVKLLGRLNALDHVITVASEH-------------- --G------------IKDIKTLLESK-- >ENSEEEP00000036531 -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ---MF--------------------------------------------- ----------------------------------------KKAKRCNFRR RNDSDDEE-------KEEx------------------------------- -------------------------------------------------- --------x----------------------------------------- -------------------------------------------------- -----------xx------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------x xxxxxxx-xxx-----------------------------------xxxx xx-x------------xx-------------------------------- -xxxxxxxxxxxxxxxxx--------------------------xxxxxx xxx--xxx------------------------------------------ -------------------------------------------------- -------------------------------------------------- -----------------------------------xxx------------ -----------------xxxxxxxxx--xP-------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ----------KAS-----------------------------------LL SF-NDD--E-ED-------------------------------------- -----------------------------------------------S-- ------EVFRVKKSNHSKKIVKQLKKEYRExx------------------ ------xxxxxxxx--------------xxxxx----------------- -------------------------------------------------- -------------------------------------------------- ------------------xxxx---------------------------- ----------------------------------SEQGEGEMEVDS---- IDEQExx------------------------------------------- ------xxxxxxx-GGAFT------------------------------- ---------------------------QTLSALSSLRP-----------G EIPDAAFIHAARKRRQMARELGGDTPLVETE-AQNKRLVR-ED--EQGG- S---xxxxxKRIVFSGVRQKSQRQKIAEE--I---GIEGSDDEALD-T-x QDEEVSRWEQEQIRKGISIPQVQTNQPEDA-NTYYQGGYEAQPYGASYGM PYAY--APV-----------------------------xxxxxxxxxKAE SSVTHPVPSTSLTPITTALVKKRLTD-R---------------------- ------------------------------------------LSSMRQGR DASARRYEQIQQELQESTRSITSLEDSSLHTAEQYKFLQEMRGYVRDLLE CFSEKVSAVLELEAAMHQLLRQRAVRRVQRRQDDIKDESAEFSSLS---- ---------------SKAVMAPNLDPFGRDRAAYQELSRQRRVAERE--- ---ARR-ARR-RQAREQSGKRVEHKEGLSSDDEETSTDITSFNLER--DR ILKESKKVFEDVVEDFHSLDCIKSRFEVWRKLYFTCYRDAYIGLCLPKLF NPLIRLQLIPWSPLE----------------------------------- -EDCPNFEYMLWFESLLFYGYEEESx-EHPEDIDAGLLPAIVERVILPKL AVLAEQVWDPLSQS--------------DTNRLVAFMRRLIKGYPTVLHG ENRNxxxxx------TVVMRTRRTLDDDVFMPLFPKNIMENKNSGPYLFS QRQFWSCVKLLGNILQWDGILSQGALKELAVDSTLNRYILSVLQTADVGE DSVEKCRRVVECFPVHWFSSLKGQQTLPQLENLCRFMKHLAASLYRSSLA ASDIDKRNAREHIKEVVKLLGRLNALDHVIDVASEH-------------- --G------------IKDIKTLLESK-- >ENSDARP00000114980 -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ---MF--------------------------------------------- ----------------------------------------KKAKRCNFRR RNDSEDEE-------KEE-------------------------------- -------------------------------------------------- --------x----------------------------------------- -------------------------------------------------- -----------xxxx----------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -----------------------------------------------xxx xx-xxxxxxxxxxxxxx--------------------------------- -----------xxxxx---------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ------------------xxxxxxxxxx---xxxxxxx------------ -----------------xxxxxxxxx--xP-------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ----------KAS-----------------------------------LL SF-QDD--E-DE-------------------------------------- -----------------------------------------------A-- ------EVFRVKKSNHSKKIVKQLKKEYKE-------------------- --------------------------------DLEKT------------- -------------------------------------------------- --------------------------------------xxxxxxxxxxx- ------xxxxxxxx-xxxxxxx---------------------------- ----------------------------------SEQGEEEMEVDS---- NEDxxxx------------------------------------------- ------xxxxxx--GGAFK------------------------------- ---------------------------ENLSALSLLRP-----------G EIPDAAFIHAARKRRQMARELGGDTPLVEND-PTNKRLVH-ED--ENGDx x---xxxxxKRIVFSGVNTKSQRQKIAEE--I---GIEGSDDEALD-N-x QDEEVSRWEQEQIRKGISIPQVQx-QPEDT-SMYYQGSYDAQPYGASYAM PFNYxxxxx-----------------------------xxx-xxxxxKAE PSVPYPIPSCELTPITTDLVKKRLQD-R---------------------- ------------------------------------------LSFMRQGH NTNARRYQQIQEDLEASKKAIRVLEGSSVEAADKYRFLQEMRGYVGDLLE CLSEKVPVILELEAAMHQLLRQRASRLVQRRQDDIKDESSEFSSLS---- ---------------SKAVMAPNLDSFGRDRTAYLELAKQRRIAERE--- ---ARR-TRR-RQAREQNDKRAEHKEGLSSDDEETSTDITSFDSER--ER ILKESKKVFEDVVEDFHSLDNIKSHFETWRKLYYSCYRDAYIGLCLPKLF NPLIRLQLISWSPLE----------------------------------- -VECSNFEYMLWFESLLFYGCGExxxxKKEEDVDNNLLPAIVERVLLPKL AVLTDQIWDPLSNS--------------QTYRLVAFMKRLVKDYPTVLHG ENRN-----TQELLRTVIMRIRRTLDDDIFLPLFPKNVMENKNSGAYLFS QRQFWSCVKFLGNILMWDGILSLSVLKDLAIDSTLNRYILSALQTTDASE EHVEKCRRVVECFPVQWFSSLKGQQTLPPLENFCRFLKHLSSSLYRSCVA GSDVEKRNVREHIKEVIRLLGRLNALDHVITVASEH-------------- --G------------IKDIKTLLEKK-- >ENSECRP00000017237 -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ---MF--------------------------------------------- ----------------------------------------KKVKRVNFRR RNNSEEEE-------EED--xxxxxxxxxxxxxxxxxxxxxxxxxxxxxx xxxxxxxxxxxxxxxxxx-------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -----------------xxxxxxxxx--xP-------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ----------KGS-----------------------------------LL SF-QDE--E-DD-------------------------------------- -----------------------------------------------N-- ------EVFKVKKSNYSKKIVKQLKKEYKD-------------------- --------------------------------DLEKIS------------ -----------------------xxxxxxxxxxxx---xxxxxxx----- --------------------------xxxxxxxxxxxxx----------- ---------------------x---------------------------- ----------------------------------AERGEEEMEVDS---- NDESDxx------------------------------------------- ---xx---------xGGFS------------------------------- ---------------------------NALSSLSTLRP-----------G EIPDAAFIHAARKRRQLARELG-xxxxNDTE-SGKKRISQ-ED--ENDV- SDxxxxxxxxxxxxx-VKEKTQRQKIAEE--I---GIEGSDDEALD-AGI QDEELNRWEQEQIRKGISIPQVQTNHQADS-NLYYQNVYEATAYGSSYGI SYSY--SSY-----------------------------GAE-DPKLLKPG STGSYTSCSNSMTPISMDLLKKRLKD-R---------------------- ------------------------------------------YESMKEVH SKNRKQYEQNQQQLESSTCLIERLEGSSDGIADQYKFLQEMQGYVRDLLE CFSEKVPLILDLESAMHHLLKRRASRLVQRRQDDIKDESSEFASHS---- ---------------SKTVVAPNLDSFGRDRKAYLENAKQRRIAERE--- ---ARR-TRR-RQSREQNGKRAEHHEGLSSDDEETSTDTTSFNLEK--ER IFQDSKKLFEDVLEDFYSIDCIKSRFEIWRKIYYRCYQDAYIGLCLPKLF NPLVRLQIIPWTPLE----------------------------------- -ANCPDFESMIWFESLLFYGCDEEEx-TQKGDVDVHLLPSIVERVIIPKL AVLIDEVWDPMSTS--------------QSARLVSFVKKLINGYPSVLNG ENKS-----TQELLKTIVMRTRRTLDDDIFMPLYPKHVLENKNSGPYLFF QRQFWSCVKLIQNILMWHGILSNKCLRELALDSLLNRYILLALQNSDPGE DCILKCQSVVECFPKQWFTNQKGQQTIPHLENFCRFLAHLTSTIYRVSIG LSDTEKRIARDHIKTVIKLLASMHAVDHVITVASEH-------------- --G------------IKDVKAFLENK--