>ENSSDUP00000004154 ----------------------------M------------------------------- ------------------------------------------------------------ -------------------------------------------TSRH------------- -----------P-----------------SHAESA---------HSTDKQP--------P --------AVAPK-----------------------LHVQRSLSKETVTIHFSAFGK-EE EEEE-----------------------E-E--LY-------------------------- ------------------------------------------------------------ ------T-----------------TTASTT-----SAAQ--------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------DDSNIVT--------------ALEASEEM------------------- ----------------------------------FEGVPLD------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------SAAEVAVIPESSRL---------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------------SPIS------ ------------------------------------------------------------ ------RHHTNSSSTQTLSSRIAEQKS--------------------------------- ------------------------------------------------------------ ------------------------------------------------------STSS-- ---------------------------------------------------------SSP TK-------S-------------------LSFPS-------------------SDKPFL- S---------LVKSLSSD-TESRDGVSS----------------------VPAP------ ------S-V-----RHR-HLMKNLVKSLSSDT-SQD----------------SSSS---- -----------SSS----TPYRLPE--SR-LNLQLFKQFTQSR----------MP-SA-- -TMSS--AGD-SKTAPSSPLTSP-DNR---SF-FKVSDVEARIEDTKRRLSEVISEPLQL LSKIMDEKS---GS-LV--------------------------------------S---- SG----------IYRPKALSVSASELSNITSIN-GHLES---NNN-YCIKEEEGGDWEA- E----------------------------------------------------------- --------------------------------------------------------SP-- ------------------------------------N----------------------- ------------------------------------------------------------ ---------------------------------SAASGPPESPVSSAVDTKSPNRSSLL- ---------SM------------------SLDKCSMSAL-AKQEDEDFCILYSDDF---- ----------------------------------------------------DTCTDTDG --GGDRTDE--------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------TGTGSQTKVPLSGS---------- -TE-------------------------------------------------PCSEDESE S-----------------------------INPV-------------------------- --------------------SSVPHYTLIILTVLVYGYFVLPLPSYIGGMLLGIGLGFLL AIGVVWLTGP---------------------------------K---------------- -------------P-SG-G-F-----------RHS---------RIN-------GKLW-- ----------------SLTK-----------------LDIKEPEIYKGWMNEISNYDPET YHATLTHSVYVRLEGAIIRLSKPNHNIARRAAHNE--PKPDVNYVSQKIYDLTNSKVYLM PQSLARKRVWNKKYPICIELGKQDDFMSK------------------------------- -AEGD------------------------------------------------------- ----------R-------------------------------CEAGEGMSIRDRGE---- ------------------------------------------------------------ --------------------------------------------------ASGGVQE--R G----------------------------------------------------------- ---------SS------------------------------------------------- --------------------------------SSRDL----------------------- --------------TLYLFGRTGREKEEWFQRFLSASR---------------------- -----------------------LKADL-KKTSSVPGSKS-------------------- ------------------------------------------------------------ ------------------A---LSSH----------------SRS------------SSR SSLDEALLSQP--RSKDS----SVSSTAAG-G---------------------------- ---AKTKPLLDYSVYMASLL---------------------PE---------------QV TV-------------------SP----TAA-----SPV-L-------------------- ------------------------------------------------------------ ---------QSPQSSPGADKK---V---------------VHVQPRG------------- ---------------EEE-----AVAWVNAALGRVFWDFLSEPYWAELVSKKIQMKLSKI RLPYFMNELTLTELDMGSATPRILGASKPSIDYRGLWFDLEISYSGSFLMTLETKMNLIR LGKE--GENLRLGEFGKDGYRPRTYCLADSDEESSSAGSSDEEDSSD------------- --------V-SNDSA-------GAEGFVGGHKPSKIMRFVDKITKSKYFQKATETEFIKK KMEEVSNTPLLLTVELQELQGTLAVNIPPPPTDRIWYGFRTPPRLELKARPKLGEREVTL AHVTDWIEKKLDQEFQ-------------------------------------------- ------------------------------------------------------------ --------------------------------------------------KIFVMPNMDD VWLTIMHSATDPRTAS-------------------------------------------- ----------------------------------GSFVV--------------------- --------------------------------P-AVDPEPS-----------QPDRENSS -QP------------------------- >ENSSLDP00000002823 ----------------------------M------------------------------- ------------------------------------------------------------ -------------------------------------------TSRH------------- -----------P-----------------SHAESA---------HSTDKQP--------P --------AVAPK-----------------------LHVQRSLSKETVTIHFSAFGK-EE EEEE-----------------------E-E--LH-------------------------- ------------------------------------------------------------ ------T-----------------TTVSTT-----SAAQ--------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------DDSNIVT--------------ALEASEEM------------------- ----------------------------------FEGAPLD------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------SAAEVAVIPESSRL---------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------------SPIS------ ------------------------------------------------------------ ------RHHTNSSSTQTLSSRIAEQKS--------------------------------- ------------------------------------------------------------ ------------------------------------------------------STSS-- ---------------------------------------------------------SFP TK-------S-------------------LSFPS-------------------SDKPFL- S---------LVKSLSSD-SESRDGVSS----------------------VPAP------ ------S-V-----RHR-HLMKNLVKSLSSDT-SQD----------------SSSS---- -----------SSS----TPYRLPE--SR-LNLQLFKQFTQSR----------MP-SA-- -TMSS--AGD-SKTAPSSPLTSP-DNR---SF-FKVSDVEARIEDTKRRLSEVMSEPLQL LSKIMDEKS---GS-LV--------------------------------------S---- SS----------IYRPKALSVSASELSNITSIN-GHLES---NNN-YCIKEEEGGDWEA- E----------------------------------------------------------- --------------------------------------------------------SP-- ------------------------------------N----------------------- ------------------------------------------------------------ ---------------------------------SAASDPPESPVSSAVDTKSPNRSSLL- ---------SM------------------SLDKCSMSAL-AKQEDEDFCILYSDDF---- ----------------------------------------------------DTCTDTDG --GGDRTED--------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------TGTGSQTKVPLSGS---------- -TE-------------------------------------------------PCSEDESE S-----------------------------INPV-------------------------- --------------------SSIPHYTLIILTVLVYGYFVLPLPSYIGGMLLGIGLGFLL AIGVVWLTGP---------------------------------K---------------- -------------P-SG-G-F-----------RHS---------RIN-------GKLW-- ----------------SLTK-----------------LDIKEPEIYKGWMNEISNYDPET YHATLTHSVYVRLEGAIIRLSKPNHNIARRAAHNE--PKPDVNYVSQKIYDLTNSKVYLM PQSLARKRVWNKKYPICIELGKQDDFMSK------------------------------- -AEGD------------------------------------------------------- ----------R-------------------------------CEAGEGMGIRDRGE---- ------------------------------------------------------------ --------------------------------------------------ASGGVQE--R G----------------------------------------------------------- ---------SS------------------------------------------------- --------------------------------SSRDL----------------------- --------------TLYLFGRTGREKEEWFQRFLSASR---------------------- -----------------------LKADL-KKTSSVPGSKS-------------------- ------------------------------------------------------------ ------------------A---LSSH----------------SRS------------SSR SSLDEALLSQP--RSKDS----SVSSTAAG-G---------------------------- ---AKTKPLLDYSVYMASLL---------------------PE---------------QV TV-------------------SP----TAA-----SPV-L-------------------- ------------------------------------------------------------ ---------QSPQSSPGADKK---L---------Q-SATSAQVQPRG------------- ---------------EEE-----AVAWVNAALGRVFWDFLSEPYWAELVSKKIQMKLSKI RLPYFMNELTLTELDMGSATPRILGASKPSIDYRGLWFDLEISYSGSFLMTLETKMNLIR LGKE--GENLRLGEFGKDGYRPRTYCLADSDEESSSAGSSDEEDSSD------------- --------V-SNDSA-------GAEGFVGGHKPSKIMRFVDKITKSKYFQKATETEFIKK KMEEVSNTPLLLTVELQELQGTLAVNIPPPPTDRIWYGFRTPPRLELKARPKLGEREVTL AHVTDWIEKKLDQEFQ-------------------------------------------- ------------------------------------------------------------ --------------------------------------------------KIFVMPNMDD VWLTIMHSATDPRTAS-------------------------------------------- ----------------------------------GSFVV--------------------- --------------------------------P-AVDPEPS-----------QPDRENSS -QP------------------------- >ENSLCAP00010023456 ----------------------------M------------------------------- ------------------------------------------------------------ -------------------------------------------TSQH------------- -----------P-----------------SHAESA---------HSTDKQP--------P --------AVAPK-----------------------LHVQRSLSKETITIHFSAFGK-EE EEEE-----------------------E-E--LY-------------------------- ------------------------------------------------------------ ------T-----------------TTVSTT-----SPTQ--------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------DDSNIVT--------------ALEASEEM------------------- ----------------------------------FEGAPSD------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------SAAEVAVIPESSRL---------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------------SPIS------ ------------------------------------------------------------ ------RHHTNSSLTQTPSLRIAEQKG--------------------------------- ------------------------------------------------------------ ------------------------------------------------------STSS-- ---------------------------------------------------------SSP TK-------S-------------------LSFPS-------------------SDKPFL- S---------LVKSLSSD-AESRDGVSS----------------------IPAP------ ------S-I-----RHR-HLMKTLVKSLSSDT-SQD----------------SPSS---- -----------STS------YRLPE--SR-LNLQLFKQFTQSR----------MP-SA-- -SMSS--AGD-SKTAPSSPLTSP-DNR---SF-FKVSDVEARIEDTKRRLSEVISEPLQL LSKIMDEKS---SN-IV--------------------------------------G---- SS----------IYRPKALSVSASELSSIASIN-GHLES---NNN-YCIKEEEGGDWEA- E----------------------------------------------------------- --------------------------------------------------------SP-- ------------------------------------N----------------------- ------------------------------------------------------------ ---------------------------------SGYSGPTESPVPSTVDTKSPNKSSSL- ---------SV------------------SLDKCSMSAL-AKQEDEDFCILYSEDF---- ----------------------------------------------------ETCTDTEG -DGGDRTDD--------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------TGTGSQTKVPLSGS---------- -TE-------------------------------------------------PCSEDESE S-----------------------------TELV-------------------------- --------------------PSVPHYTLIILTLLVYGYFVLPLPSYIGGLLLGVGLGFLL AIGVVWLTGP---------------------------------K---------------- -------------P-SG-G-F-----------RHS---------RHH-------GKLW-- ----------------NVTK-----------------LDIKEPEIYKGWMNEISNYDPET YHATLTHSVYVRLEGSIIRLSKPNHNIARRATHNE--PKPDVTYISQKIYDLTNSKVYLM PQNLARKRVWNKKYPICIELGKQDDFMSK------------------------------- -AEGD------------------------------------------------------- ----------R-------------------------------WEANEGMSIKERGEGI-- ----------------------------------------GVAQERGVLPSS-------- -------------------------------------------------T---------- ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------RDL----------------------- --------------TLYLFGRTGREKEEWFQRFLSASR---------------------- -----------------------LKADL-KKSSSVAGSKT-------------------- ------------------------------------------------------------ ------------------A---LSSH----------------SRS------------SSR SSLDEALISQP--RSKDS----SVSS-SAG-S---------------------------- ---AKTKLPLDYSVYMASLL---------------------PE---------------QA IV-------------------SP----AAT-----SPA-V-------------------- ------------------------------------------------------------ ---------QSPQSSPGADKK---L---------Q-STTSAQVQPTG------------- --------------EEED-----AVAWVNAALGRVFWDFLGEPYWAELVSKKIQMKLSKI RLPYFMNELTLTELDMGIVTPRILGASKPSIDYRGLWFDLEISYRGSFLMTLETKMNLIR LGKE--GDSLRLGEFGKDGYRPRTYCLADSDEESSSAGSSDEEDSSE------------- --------L-SNDSA-------GAEGLVGGHKPSKIMRFVDKITKSKYFQKATETEFIKK KMEEVSNTPLLLTVEVQELQGTLAVNIPPPPTDRIWYGFRTPPHLELKARPKLGEREVTL AHVTDWIEKKLDQEFQ-------------------------------------------- ------------------------------------------------------------ --------------------------------------------------KIFVMPNMDD VWLTIMHSAMDPRTAG-------------------------------------------- ----------------------------------GPLVG--------------------- --------------------------------P-SVDPEPS-----------QPDRDSSS -QP------------------------- >ENSAOCP00000031513 ----------------------------M------------------------------- ------------------------------------------------------------ -------------------------------------------TSRH------------- -----------P-----------------SHAEST---------HSTDKQP--------P --------TVAPK-----------------------LHVHRSLSKETITIHFSALGK-EE EEEE-----------------------E-E--LY-------------------------- ------------------------------------------------------------ ------T-----------------TTVSTT-----S------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------HDTNVVT--------------ALEASEEM------------------- ----------------------------------FEGVPVD------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------SVVGVGVIPESSRL---------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------------SPIS------ ------------------------------------------------------------ ------KHHTNSSPTWTPSSNVSEQKA--------------------------------- ------------------------------------------------------------ ------------------------------------------------------SISN-- ---------------------------------------------------------SSP TK-------S-------------------LSFPS-------------------SDKPLR- S---------MVKSLSSD-VESRDGVSS----------------------IPTP------ ------S-V-----RHR-HLMKTLVKSLSSDT-SQD--------------SSSSSS---- -----------SSS----TPYRLPE--SR-LNLQLFKQFTQSR----------IP-SA-- -AVSS--VTD-SKTAPSSPLTSP-DNR---SF-FKVSEVEARIEDTKRRLSEVISEPLQL LSKIMDEKS---GS-LV--------------------------------------S---- SS----------IYRPKALSASASELSNIASIN-GHLES---NNN-YCIKEEEGGDWEA- E----------------------------------------------------------- --------------------------------------------------------GP-- ------------------------------------N----------------------- ------------------------------------------------------------ ---------------------------------SGVSGTAESPVNPSVDTKSPVKSSSL- ---------TM------------------SLDKCSMSAL-AKQEDEDFCILYSEDF---- ----------------------------------------------------DTCTDTDG -DGADRTDN--------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------TGSGSQTKVPLSGS---------- -TE-------------------------------------------------PCSDDESE S-----------------------------SGPA-------------------------- --------------------PSVPHYTLSILTVLVYGYFVLPLPSYVGGLLLGIGLGFLL AIGVVWLTGP---------------------------------K---------------- -------------L-SG-SDF-----------RHS---------RHR-------EEMW-- ----------------NLTK-----------------LDIKEPEIYKGWMNEILNYDPET YHATLTHSVYVRLEGSIIRLSKPNHNIARRATHNE--TKPDVTYISQKIYDLTNCKVYLV PQSLARKRIWNKKYPICIELGKQDDFMSK------------------------------- -AEGD------------------------------------------------------- ----------R-------------------------------WEAGEGMSTRDRGE---- ------------------------------------------------------------ --------------------------------------------------GMGGVQD--R G----------------------------------------------------------- --------FSS------------------------------------------------- --------------------------------SSRDL----------------------- --------------TLYLFGRTGREKEEWFQRFLSASK---------------------- -----------------------LKAEL-KKSSSVVGSKK-------------------- ------------------------------------------------------------ ------------------T---SSSH----------------SRS------------SSR SSLDEALASQP--RPKDS----SASSSMAA-S---------------------------- ---AKTKPPLDYSVYMGSLL---------------------PK---------------QL AV-------------------SP----TAA-----SPV-L-------------------- ------------------------------------------------------------ ---------QSPQSSPGADKK---L---------P-NTTSAQVKPMG------------- --------------EEED-----TVAWVNAALGRVFWDFLTEPYWAELVSKKIQMKLSKI RLPYFMNELTLTELDMGSATPRILGASKPSIDYRGLWFDLEVSYSGSFLMTLETKMNLIR LGKE--GENLRLGEFGKDGYRPRTYCLADSDEESSSAGSSDEEDSSD------------- --------F-SNDSA-------GAEGLVGGHKPSKIMRFVDKITKSKYFQKATETEFIKK KMEEVSNTPLLLTVEVQQLQGTLAVNIPPPPTDRIWYGFRTPPRLELKARPKLGEREVTL AHVTDWIEKKLDQEFQ-------------------------------------------- ------------------------------------------------------------ --------------------------------------------------KILVMPNMDD VWLTIMHSAMDPRTAG-------------------------------------------- ----------------------------------GPLVG--------------------- --------------------------------L-SMDPEPS-----------QPERDNNG -QP------------------------- >ENSAPEP00000021293 ----------------------------M------------------------------- ------------------------------------------------------------ -------------------------------------------TSRH------------- -----------P-----------------SHAEST---------HSTDKQP--------P --------AVAPK-----------------------LHVHRSLSKETITIHFSALGK-EE EEEE-----------------------E-E--LY-------------------------- ------------------------------------------------------------ ------T-----------------TTVSTT-----S------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------HDTNVVT--------------ALEASEEM------------------- ----------------------------------FEGVSVD------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------SVVGVGVIPESSRL---------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------------SPIS------ ------------------------------------------------------------ ------KHHTNSSPTWTPSSNVSEQKA--------------------------------- ------------------------------------------------------------ ------------------------------------------------------SISN-- ---------------------------------------------------------SSP TK-------S-------------------LSFPS-------------------SDKPLR- S---------MVKSLSSD-VESRDGVSS----------------------IPTP------ ------S-V-----RHR-HLMKTLVKSLSSDT-SQD--------------SSSSSS---- -----------SSS----TPYRLPE--SR-LNLQLFKQFTQSR----------IP-SA-- -AVSS--VTD-SKTAPSSPLTSP-DNR---SF-FKVSEVEARIEDTKRRLSEVISEPLQL LSKIMDEKS---GS-LV--------------------------------------S---- SS----------IYRPKALSASASELSNIASIN-GHLES---NNN-YCIKEEEGGDWEA- E----------------------------------------------------------- --------------------------------------------------------GP-- ------------------------------------N----------------------- ------------------------------------------------------------ ---------------------------------SGVSGTAESPVNPSVDTKSPVKSSSL- ---------TM------------------SLDKCSMSAL-AKQEDEDFCILYSEDF---- ----------------------------------------------------DTCTDTDG -DGADRTDN--------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------TGSGNQTKVPLSGS---------- -TE-------------------------------------------------PCSDDESE S-----------------------------SGPA-------------------------- --------------------PSVPHYTLSILTVLVYGYFVLPLPSYVGGLLLGIGLGFLL AIGVVWLTGP---------------------------------K---------------- -------------L-SG-SDF-----------RHS---------RHR-------EEMW-- ----------------NLTK-----------------LDIKEPEIYKGWMNEILNYDPET YHATLTHSVYVRLEGSIIRLSKPNHNIARRATHNE--TKPDVTYISQKIYDLTNCKVYLV PQSLARKRIWNKKYPICIELGKQDDFMSK------------------------------- -AEGD------------------------------------------------------- ----------R-------------------------------WEAGEGMSTRDRGE---- ------------------------------------------------------------ --------------------------------------------------GMGGVQD--R G----------------------------------------------------------- --------FSS------------------------------------------------- --------------------------------SSRDL----------------------- --------------TLYLFGRTGREKEEWFQRFLSASK---------------------- -----------------------LKAEL-KKSSSVVGSKK-------------------- ------------------------------------------------------------ ------------------T---SSSH----------------SRS------------SSR SSLDEALASQP--RPKDS----SASSSMAA-S---------------------------- ---AKTKPPLDYSVYMGSLL---------------------PK---------------QL AV-------------------SP----TAA-----SPV-L-------------------- ------------------------------------------------------------ ---------QSPQSSPGADKK---L---------P-NTTSAQVKPMG------------- --------------EEED-----TVAWVNAALGRVFWDFLTEPYWAELVSKKIQMKLSKI RLPYFMNELTLTELDMGSATPRILGASKPSIDYRGLWFDLEVSYSGSFLMTLETKMNLIR LGKE--GENLRLGEFGKDGYRPRTYCLADSDEESSSAGSSDEEDSSD------------- --------F-SNDSA-------GAEGLVGGHKPSKIMRFVDKITKSKYFQKATETEFIKK KMEEVSNTPLLLTVEVQQLQGTLAVNIPPPPTDRIWYGFRTPPRLELKARPKLGEREVTL AHVTDWIEKKLDQEFQ-------------------------------------------- ------------------------------------------------------------ --------------------------------------------------KILVMPNMDD VWLTIMHSAMDPRTAG-------------------------------------------- ----------------------------------GPLVG--------------------- --------------------------------L-SMDPEPS-----------QPERDSNG -QP------------------------- >ENSAPOP00000018460 ----------------------------M------------------------------- ------------------------------------------------------------ -------------------------------------------TSRH------------- -----------P-----------------SHAEST---------HSTDKQS--------P --------AVAPK-----------------------LHVHRSLSKETITIHFSALGK-EE EEEE-----------------------E-E--LY-------------------------- ------------------------------------------------------------ ------T-----------------TTVSTT-----S------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------HDSNVAT--------------ALEASEEV------------------- ----------------------------------FEGVPED------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------SADGVGVSPESSSL---------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------------SPIS------ ------------------------------------------------------------ ------KHHTNSSPTWAPSSDVSEQKA--------------------------------- ------------------------------------------------------------ ------------------------------------------------------SISN-- ---------------------------------------------------------SSP TK-------S-------------------LSFPS-------------------SDKSLR- S---------MVKSLSSD-VESRDGVSS----------------------ITTP------ ------S-V-----RHR-HLMKTLVKSLSSDT-SQD--------------SSSSSS---- -----------SSS----TLYRLPE--SR-LNLQLFKQFTQSR----------IP-SA-- -AVSS--VSD-SKTAPSSPLTSP-DNR---SF-FKVSEVEARIEDTKRRLSEVISEPLQL LSKIMDEKS---GS-LV--------------------------------------S---- SS----------IYRPKALSASATELSNIAPVN-GHLES---NNN-YCIKEEEGGDWEA- E----------------------------------------------------------- --------------------------------------------------------GP-- ------------------------------------N----------------------- ------------------------------------------------------------ ---------------------------------SGVCGTAESPVNPSVDTKSPVKSSSL- ----------------------------------SMSAL-AKQEDEDFCILYSEDF---- ----------------------------------------------------DTCTDADG -DGADRTDN--------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------TGSGSQTKVPLSGS---------- -TE-------------------------------------------------PCSEDESE S-----------------------------SGPA-------------------------- --------------------PSVPHYTLSVLTVLVYGYFVLPLPSYIGGLLLGIGLGFLL AIGVVWLTGP---------------------------------K---------------- -------------P-SG-GDF-----------RHS---------RHR-------EEMW-- ----------------NLTK-----------------LDIKEPEIYKGWMNEILNYDPET YHATLTYSVYVRLEGSIIRLSKPNHNIARRATHNE--TKPEVTYISQKIYDLTNCKVYLV PQSLARKRIWNKKYPICIELSKQDDFMSK------------------------------- -AEGD------------------------------------------------------- ----------R-------------------------------WEASEGMSTRDRGE---- ------------------------------------------------------------ --------------------------------------------------GMGGVQE--R G----------------------------------------------------------- --------FSS------------------------------------------------- --------------------------------SSRDL----------------------- --------------TLYLFGRTGREKEEWFQRFLSASK---------------------- -----------------------LKADL-KKSSSVLGSKK-------------------- ------------------------------------------------------------ ------------------T---SSSH----------------SRS------------SSR SSLDEALASQP--RPKDS----SASSSMAT-N---------------------------- ---AKTKPPLDYSVYMGSLL---------------------PK---------------QL AV-------------------SP----TAA-----SPV-L-------------------- ------------------------------------------------------------ ---------QSPQSSPGADKK---L---------P-NTTSAQVKPRG------------- --------------EEED-----TVAWVNAALGRVFWDFLTEPYWAELVSKKIQMKLSKI RLPYFMNELTLTELDMGSATPRILGASKPSIDYRGLWFDLEVSYSGSFLMTLETKMNLIR LGKE--GENLRLGELGKDGYRPRTYCLADSDEESSSAGSSDEEDTSD------------- --------F-SNDSA-------GAEGLVGGHKPSKIMRFVDKITKSKYFQKATETEFIKK KMEEVSNTPLLLTVEVQQLQGTLAVNIPPPPTDRIWYGFRTPPRLELKARPKLGEREVTL AHVTDWIEKKLDQEFQ-------------------------------------------- ------------------------------------------------------------ --------------------------------------------------KILVMPNMDD VWLTIMHSAMDPRTAG-------------------------------------------- ----------------------------------GPLVG--------------------- --------------------------------L-SVDPEPS-----------QPERDSTS -QP------------------------- >ENSSPAP00000011611 ----------------------------M------------------------------- ------------------------------------------------------------ -------------------------------------------TSRH------------- -----------P-----------------SHAEST---------HSSDKQP--------P --------AVAPK-----------------------LHVHRSLSKETITIHFSALGK-EE EEEE-----------------------E-E--LY-------------------------- ------------------------------------------------------------ ------T-----------------TTVSAT-----SAAL--------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------DDSNIVT--------------ALEASEEM------------------- ----------------------------------FEGVPVD------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------SAAGVGVIPESSRL---------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------------SPIS------ ------------------------------------------------------------ ------RHHTNSSPTRTLSSHASEQKA--------------------------------- ------------------------------------------------------------ ------------------------------------------------------STSN-- ---------------------------------------------------------SSP TK-------S-------------------LSFPS-------------------SDKPFL- S---------MVKSLSSD-AESRDGVSP----------------------IPAP------ ------S-V-----RHR-HLMKTLVKSLSIDT-SQDS------------SSSSSSS---- -----------SSS----TPYRLPE--SR-LNLQLFKQFTQSR----------IP-SA-- -AASS--LSD-SKTAPSSPLTSP-DNR---SF-FKVSEVEARIEDTKRRLSEAISEPLQL LSKIMDEKS---GS-LV--------------------------------------G---- SS----------IYRPKALSASASELSNIASVN-GHLES---NNN-YCIKEEEGGDWEA- E----------------------------------------------------------- --------------------------------------------------------GP-- ------------------------------------N----------------------- ------------------------------------------------------------ ---------------------------------SRVSGTAESPVSLSVDTKSPNKSSPL- ---------SM------------------SLDKCSMSAL-AKQEDEDFCILYSDDF---- ----------------------------------------------------DTCTETDG -DGVDRTDN--------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------TGSGSQTKVPLSGS---------- -TE-------------------------------------------------PCSEDESE S-----------------------------IAPA-------------------------- --------------------PSVPHYTLSILTVLVYGYFVLPLPSYVGGMLLGIGLGFLL AIGVVWLTGP---------------------------------K---------------- -------------P-SG-GDF-----------RHS---------RHR-------GEMW-- ----------------SLTK-----------------LDIKEPEIYKGWMNEILNYDPET YHATLTHSVYVRLEGSIIRLSKPNHNIARRATHNE--PKPDVTYISQKIYDLTNSKVYLA PQSLARKRIWNKKYPICIELGKQDDFMSK------------------------------- -AEGD------------------------------------------------------- ----------R-------------------------------WEASEGVSTRDRGE---- ------------------------------------------------------------ --------------------------------------------------ATGGGQD--R G----------------------------------------------------------- --------WSS------------------------------------------------- --------------------------------SARDL----------------------- --------------TLYLFGRTGREKEEWFQRFLSASK---------------------- -----------------------LKADL-KKSSSVVGSKK-------------------- ------------------------------------------------------------ ------------------A---LSSH----------------SRS------------SSR SSLDEALASQP--RPKDS----SASSTMAA-S---------------------------- ---AKAKPLLDYSVYMGSLL---------------------PK---------------QL AV-------------------SP----TAA-----SPV-L-------------------- ------------------------------------------------------------ ---------QSPQSSPGADKK---L---------Q-STTSAPLQPRGEE----------- -----------E--EEED-----AVAWVNAALGRVFWDFLTEPYWAELVSKKIQMKLSKI RLPYFMNELTLTELDMGSATPRILGASKPSIDYRGLWFDLEISYRGSFLMTLETKMNLIR LGKE--GDSLRLGEFGKDGYRPRTYCLADSDEESSSAGSSDEEDSSD------------- --------F-SNDSA-------GADGLVGGHKASKIMRFVDKITKSKYFQKATETEFIKK KMEEVSNTPLLLTVEVQQLRGTLAVNIPPPPTDRIWYGFRTPPHLELKARPKLGEREVTL AHVTDWIEKKLDQEFQ-------------------------------------------- ------------------------------------------------------------ --------------------------------------------------KILVMPNMDD VWLTIMHSAMDPRSAG-------------------------------------------- ----------------------------------GPSVG--------------------- --------------------------------LPAADPEPW-----------QPERDSTS -QP------------------------- >ENSSMAP00000019147 ----------------------------M------------------------------- ------------------------------------------------------------ -------------------------------------------TSRH------------- -----------P-----------------SHAESG---------HSTDKQP--------P --------AAAPK-----------------------LHVQRSLSKENITIHFSAFGT-EE EEEE-----------------------E-E--LN-------------------------- ------------------------------------------------------------ ------C-----------------ITVSTT-----SATQ--------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------NDSNIVT--------------ALEASEEM------------------- ----------------------------------FEAVPLD------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------SADEVAVIPETSRL---------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------------SPFS------ ------------------------------------------------------------ ------KHHTIGSPTQTLTSRIAEQKG--------------------------------- ------------------------------------------------------------ ------------------------------------------------------SISS-- ---------------------------------------------------------SSP TK-------S-------------------LSFPS-------------------SEKPFL- S---------LVKSLSSEVSEIRDGVSS----------------------VPAP------ ------S-V-----RHR-HLMKSLVKSLSSDT-SQD------------------SS---- -----------SSS----TPYRLPE--SR-LNLQLFKQFAQSR----------MP-SA-- -TMSS--AAD-SKTAPSSPLTST-DNR---SF-FKVSDVEARIEDTKRRFSEVISEPLQL LSKIMDEKS---SS-LV--------------------------------------S---- GS----------LYRPKGLSVSASELSNITSIN-CHVES---NNN-NCIKEEEGGDWED- E----------------------------------------------------------- --------------------------------------------------------RV-- ------------------------------------N----------------------- ------------------------------------------------------------ ---------------------------------SGASGPPESQVPSTVHTKSPNKPSLL- ---------SM------------------SLENCSMSAL-AKQEDEDFCILYTEDF---- ----------------------------------------------------ETCADTEG -DGGDRTDD--------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------TGTGSQTKVLLSGS---------- -TE-------------------------------------------------PCSEDESE N-----------------------------TVPV-------------------------- --------------------PCVPHYTLIILTVLVYGYFVLPLPSYIGGMLLGTVFGFFL AIGVVWLTGP---------------------------------K---------------- -------------P-SG-G-F-----------RRT---------RHH-------GKLW-- ----------------NLTK-----------------LDIKEPEIFKGWMNEILNYDPEM YHATLTHSVYVRLEGSIIRLSKPNHNIARRATHNE--PKPDVNYISQKIYDLTNSKVYLM PQSLARKRVWNKKYPICIELGKQDDFMSK------------------------------- -AEDD------------------------------------------------------- ----------G-------------------------------LEANEGTGVRDRGE---- ------------------------------------------------------------ --------------------------------------------------SSGEAQE--R G----------------------------------------------------------- ---------SPP------------------------------------------------ -------------------------------WSSRDL----------------------- --------------TLYLFGRTGREKEEWFQRFLSASK---------------------- -----------------------LKVDL-KKTPSVTASKS-------------------- ------------------------------------------------------------ ------------------A---LSSH----------------SRS------------SSR SSLDEALIPQP--RPKDL----SVSSTAAG-S---------------------------- ---AKTKPLLDYSVYMASLL---------------------PK---------------RS TV-------------------SP----PAA-----SPA-L-------------------- ------------------------------------------------------------ ---------QSPQSSPGADKK---L---------Q-STTSAQV-----L----------- ----------HR--EEEEEEEAAAVAWVNAALGRVLWDFLVEPYWADLVSKKIQMKLSKI RLPYFMNELTLTELDMGSATPRILGASKPSIDYRGLWFDLELSYSGSFLMTLETKMNLIR LGKE--GESFRLGEFGKDGYRPRTYCLADSDEESSSAGSSDEEDSSE------------- --------L-SNDSA-------GAEGLVGGHKPSKIMRFVDKITKSKYFQKATETEFIKK KMEEVSNTPLLLTVEVQELQGTLVVNIPPPPTDRIWYGFRTPPHLELKARPKLGEREVTL PHVTDWIEKKLIQEFQ-------------------------------------------- ------------------------------------------------------------ --------------------------------------------------KVFVMPNMDD LWLTIMHSAMDPRTAS-------------------------------------------- ----------------------------------GPSAG--------------------- --------------------------------P-TVDPEPS-----------QPERDSSS -QP------------------------- >ENSLCRP00005058935 ----------------------------M------------------------------- ------------------------------------------------------------ -------------------------------------------TSQP------------- -----------P-----------------SHAESA---------HSTKKQP--------P --------AVSPK-----------------------LHVQRSPSKETITIHFSALGK-EE EEEE-----------------------E-EEELY-------------------------- ------------------------------------------------------------ ------M-----------------TNVSTT-----SAAQ--------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------DDSNIVT--------------ALEACEEM------------------- ----------------------------------FEQLPAD------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------SAAEVPVIPESSRL---------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------------SPLS------ ------------------------------------------------------------ ------RRHTNSSPTQTLSSRVAEPKG--------------------------------- ------------------------------------------------------------ ------------------------------------------------------ST---- ---------------------------------------------------------SSP TK-------S-------------------LSFPS-------------------SDKPFL- S---------LVKSLSSD-IESRDGIPS----------------------VPVP------ ------T-V-----RHR-HLMKTLVKSLSSDT-SQD---------------SSSSS---- -----------SSF----TPYRLPE--PR-LNLQLFKQFTQSR----------MP-SA-- -TASS--ASD-SKTAPSSPLTSP-DNR---SF-FKVAEVEAKIEDTKRRLSEVISEPLQL LSKIMDEKS---G----------------------------------------------- -S----------IYRPKPLSASATELSNIAAIN-GHLES---NNN-YCIKEEEGGDWEA- E----------------------------------------------------------- --------------------------------------------------------SP-- ------------------------------------N----------------------- ------------------------------------------------------------ ---------------------------------SGASG--ESPVPLSIDTKSPNKSSLL- ---------SL------------------SLDKCSMSAL-VKQEDEDYCILYSEDF---- ----------------------------------------------------ETCTDTEG -DGGDRTDD--------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------TGTGSHTKVPLSGS---------- -TE-------------------------------------------------PCSEDESE S-----------------------------IEPA-------------------------- --------------------PSVPHYTLIILTLLVYGYFVLPLPDYVGGMLFGIGLGFLL AIGVVWLTGP---------------------------------K---------------- -------------P-SG-SSF-----------RHS---------RHR--------KLW-- ----------------NLTK-----------------LDIKEPEIYKGWMNEISNYDPET YHATLTHSVYVRVEGSIIRLSKPNHNIARRATHNE--PKPDVTYISQKIYDLTNSKVYLV PHGLARKRLWNKKYPICIELGKQDDFMSK------------------------------- -TEGD------------------------------------------------------- ----------R-------------------------------WEASESSSTKDRGE---- ------------------------------------------------------------ --------------------------------------------------GTGGAQE--R R----------------------------------------------------------- ---------SS------------------------------------------------- --------------------------------SSRDL----------------------- --------------TLYLFGRTGREKEAWFQRFLSASK---------------------- -----------------------LKVDS-KKASSVAVTKS-------------------- ------------------------------------------------------------ ------------------A---LNSH----------------SRR------------SSR SSLDETLASQP--RSKDS----LASATTAG-N---------------------------- ---AKSKPLLDYSVYMASIL---------------------PK---------------QA SV-------------------SP----KAA-----SPT-L-------------------- ------------------------------------------------------------ ---------QSPQSSPGADKK---L---------Q-STTSAQAQPSG------------- -----------E--EEDD-----TVSWVNAALGRVVWDFLSEPHWAELVSKKIQMKLSKI RLPYFMNELTLTELDMGSATPRILGASKPSIDYQGLWFDLEISYSGSFLMTLETKMNLIR LGKE--GESVRLGEFGKDGYRPRTYCLADSDEESSSAGSSDEEDSSE------------- --------L-SNDSA-------GAEGWAGGHKPSKIMRFVDKITKSKYFQKATETEFIKK KMEEVSNTPLLLTVELQELRGTLAVNIPPPPTDRIWYGFRTPPHLELKARPKLGEREVTL AHVTDWIEKKLDQEFQ-------------------------------------------- ------------------------------------------------------------ --------------------------------------------------KIFVMPNMDD VWLTIMHSAMDPRTAG-------------------------------------------- ----------------------------------GPLVC--------------------- --------------------------------P-AVDPEPP-----------QPDRDSTS -QP------------------------- >ENSMAMP00000009079 ----------------------------M------------------------------- ------------------------------------------------------------ -------------------------------------------TSQH------------- -----------P-----------------SHADGP---------HSTDKQL--------P --------AVAPN-----------------------VHMQRSLSKETITIRFSAFGT-EE EEEE-----------------------E-E--LY-------------------------- ------------------------------------------------------------ ------T-----------------TTVSTT-----SATQ--------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------DYSNIVT--------------ALEASEEM------------------- ----------------------------------FEGVPVD------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------SAAEV-VIPE-SRL---------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------------SPVS------ ------------------------------------------------------------ ------RRHTNSSPTQTLPSRIAEQKG--------------------------------- ------------------------------------------------------------ ------------------------------------------------------STSN-- ---------------------------------------------------------SSP SK-------S-------------------LSFPS-------------------IDKPFL- S---------LVKSQSSD-AEARDGVCS----------------------IPAP------ ------S-L-----RHR-HLMKNIVKSLSSDT-SQD----------------STSS---- -----------SA------PYRLPE--SR-LNLQLFKQFTQSR----------IP-SA-- -AMSS--ASD-SKTAPSSPLTSP-DNR---SF-FKVSDVEARIEDTKRRLSEVISEPFQL LSKIMDEKS---GS-LV--------------------------------------S---- SS----------IYRPKALSASASELSSITSIN-GHLES---NNN-YCIKEEEGGDCEA- E----------------------------------------------------------- --------------------------------------------------------SP-- ------------------------------------N----------------------- ------------------------------------------------------------ ---------------------------------SKTSGLPESLISSSVDTKSPNKSSLL- ---------SM------------------SLDKCSMSAL-AKQEDDDFCVLYSEDF---- ----------------------------------------------------ETCTDTEG -NGGDGTNDKAT---------------------------VS-------------QNKLPP S----------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------DSTG---------------------- ----------------------------------------------------PCSDDESE S-----------------------------IEPA-------------------------- --------------------PSVPYYTLIILTLLIYGYFVLPLPNYVGGVVLGIGLGFFL AIGVVWLTGP---------------------------------K---------------- -------------P-TG-G-F-----------RHF---------RHH-------GKLW-- ----------------NLAR-----------------LDIKEPEIYKGWMNEISNYDPET YHATLTHSVYVRLEGSIIRLSKPNHNIARRATHNE--PKPDVSYISQKIYDLTNSKVYLM PQNLARKRVWNKKYPICIELGKQDDFMSK------------------------------- -TEGD------------------------------------------------------- ----------R-------------------------------WEA--------------- ---------------------------------------------------G-------- -------------------------------------------------DGRGGTQE--R G----------------------------------------------------------- --------FSS------------------------------------------------- -------------------------------CSSRDL----------------------- --------------TLYLFGRTGREKEEWFQRFLSASK---------------------- -----------------------LKANL-KKTSSFVGSKS-------------------- ------------------------------------------------------------ ------------------A---LSSH----------------SRS------------SSR SSLDEALASQP--RSKDS----SVSSTTAG-S---------------------------- ---AKTKPQLDYCVYMASLL---------------------PE---------------EV TA-------------------SP----AAA-----SPP-L-------------------- ------------------------------------------------------------ ---------QSPQSSPGADKK---L---------Q-ST-SAQVQSRGEEE-----EEEKV ----------EE--KEEE-----TVAWVNAALGRVFWDFLGEPYWAELVSKKIQMKLSKI RLPYFMNELTLTELDMGSVTPRILGASKPSVDYRGLWFDLEISYSGSFLMTLETKMNLIR LGKE--GEGLRVGEFGKDGYRPRTYCLADSDEESSSAGSSDEEDSSE------------- --------L-SNDSA-------GAEGLVGGHKPSKIMRFVDKITKSKYFQKATETEFIKK KMEEVSNTPLLLTVELQELQGTLSVNIPPPPTDRIWYGFRKPPHLELKARPKLGVREVTL AHVTDWIEKKLDQEFQ-------------------------------------------- ------------------------------------------------------------ --------------------------------------------------KIFVMPNMDD VWLTIMHSAMDPRTAG-------------------------------------------- ----------------------------------GPLVG--------------------- --------------------------------P-SVDPEPS-----------QLERESTS QQP------------------------- >ENSATEP00000034029 ----------------------------M------------------------------- ------------------------------------------------------------ -------------------------------------------TSQH------------- -----------S-----------------SHAESA---------HSTDKQP--------P --------AVAPK-----------------------LHVQRSLSKDTITIHFSAFGKDEE EEEE-----------------------E-E--LY-------------------------- ------------------------------------------------------------ ------S-----------------TTVSTT-----SATQ--------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------DDSNIVT--------------AVEASEEM------------------- ----------------------------------FEGVPLD------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------SAVEVAVLPESSRL---------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------------SPIS------ ------------------------------------------------------------ ------RRHTNGSPTQTLSACIAEQKG--------------------------------- ------------------------------------------------------------ ------------------------------------------------------LTSN-- ---------------------------------------------------------SSP TK-------S-------------------LSFPS-------------------SDKPFL- S---------LVKSFSSD-AEARDGNTS----------------------IPGP------ ------S-V-----RHR-HLMKTLVKSFSSDT-SQD---------------SSSSS---- -----------SA------SYRLPE--SR-LNLQLFKQFTQSR----------MP-SA-- -TTLS--TGD-SKTAPSSPLTSP-DNR---SF-FKVSDVEARIEDTKRRLSEVISEPLQL LSKIMDEKS---SS-LV--------------------------------------S---- SS----------IYRPKALSASASELS-IASIN-GHLES---NNN-YCIKEEEGGEWEA- E----------------------------------------------------------- --------------------------------------------------------SP-- ------------------------------------NCIAT---------VS-------- ------------------------------------------------------------ -------------------------------PDS---------VPSSVDTKSPSKSTSL- ---------SM------------------SLDKCSMSAL-AKQEDEDFCILYSDDF---- ----------------------------------------------------ETCTDTDG -DGVDGTDE--------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------TGTGSQTKMPLSGS---------- -TE-------------------------------------------------PCSEDESE S-----------------------------IELT-------------------------- --------------------PSVPHYTLIILTVMVYGYFVLPMPSYIGGMLLGIGLGFLL AIGVVWLTGP---------------------------------K---------------- -------------P-SG-G--------------HI---------RCH-------GKLS-- ----------------KITK-----------------LDIKEPEIYKGWMNEISNYDPET YHATLTHSVYVRLEGSIIRLSKPNRNIARRATHSE--PKPDVTYISQKIYDLTNSNVYLV PHSLARKRVWNKKYPICIELGKQDDFMSK------------------------------- -AEGD------------------------------------------------------- ----------R-------------------------------WEASEGLSTRDRGD---- ------------------------------------------------------------ --------------------------------------------------GSGGALE--R G----------------------------------------------------------- --------VSS------------------------------------------------- --------------------------------SPRDIG---------------------- -------------QTLYLFGRTGREKEEWFQRFLSAAR---------------------- -----------------------LKADL-KKSSSFPGTQ--------------------- ------------------------------------------------------------ -----------------------SSH----------------SRS------------SSR SSLDEALASQP--KSKDF----TVYSAMVG-S---------------------------- ---VKTKPQLDYSVYMASVL---------------------PK---------------QA AV-------------------NP----VAA-----SPS-V-------------------- ------------------------------------------------------------ ---------QSPQSSPGADKK---L---------Q-NTTSAQLQPRE------------- ----------EE--EEEE-----AVAWVNAALGRIFWDFLSEPHWADLVSKKIQMKLSKI RLPYFMNELTLKELDMGSVTPRILGASKPSIDFRGLWFDLEISYSGSFMMTLETKMNLSR LGKE--GEGLRLGEFGKDGSRPRTYCLADSDEESSSAGSSDEEDSSE------------- --------L-SNESA-------GAEGLVGGHKPSKIMRFVDKITKSKYFQKATETEFIKK KMEEVSNTPLLLTVELQELQGTLAVNVPPPPTDRIWYGFRSPPHLELKARPKLGEREVTL GHVTDWIEKKLDQEFQ-------------------------------------------- ------------------------------------------------------------ --------------------------------------------------KVFVMPNMDD VWLTIMHSAMDPRTAG-------------------------------------------- ----------------------------------GPLVS--------------------- --------------------------------P-PMDQDNS-----------QPERDSTT -PP------------------------- >ENSCGOP00000011773 ----------------------------M------------------------------- ------------------------------------------------------------ -------------------------------------------TGRH------------- -----------P-----------------SHAGSA---------HSTEKQP--------S --------VPSPK-----------------------LHVQRSTSKENITIHFSALGK-EE EEEE-----------------------E-E--LY-------------------------- ------------------------------------------------------------ ------R-----------------TTVSTT-----SAAQ--------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------DDSNIVT--------------AVEASEEM------------------- ----------------------------------FECVPLD------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------SAAKVAGTPESSRL---------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------------SAVS------ ------------------------------------------------------------ ------KHHPNRSPAQTPPSHNAEQKG--------------------------------- ------------------------------------------------------------ ------------------------------------------------------STYN-- ---------------------------------------------------------SSP TK-------S-------------------LSFPS-------------------SDKPFF- S---------MMKSLSSD-SESCEGIPA------------------------AP------ ------T-V-----RHR-HLMKTLVKSLSSDT-SQD----------------SPSS---- -----------SSS----TPFRLPE--SR-LNLQLFKQFTQSR----------MP-SA-- -TTSS--AGD-SKTAPSSPLIST-DTR---SF-FKVSEVEAKIEDTKRRFSEAISEPLQL LSKMIDEKS---GS-LV--------------------------------------G---- SS----------IYRPKVLSASASELSNITSIN-GHLES---NNN-YCIKEEEGGDLEA- E----------------------------------------------------------- --------------------------------------------------------SP-- ------------------------------------S----------------------- ------------------------------------------------------------ ---------------------------------FRASGPAESSVPPSVDTKSPNR-SLL- ---------SM------------------SLDKCSMSAL-AKQDDEDFCILYSDDF---- ----------------------------------------------------ETYTETEG ----DRTDD--------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------TGTGSHTKEPLSGS---------- -TE-------------------------------------------------PCSEDESE S-----------------------------IEPV-------------------------- --------------------PSVPHYTLIILTVLVYGYFVLPLPSYVGGLLLGVGLGFLL AIGVVWLTGP---------------------------------K---------------- -------------P-SD-GAF-----------RHS---------RHH-------GKLW-- ----------------NLTK-----------------LDIKEPEIYKGWMNEISNYDPET YHATLTQSVYVRLEGSIIRLSKPNRNVARRATHNE--PKHDVTYISQKIYDITNSKVYLA PQSLARKRIWNKKYPICIELGKQDDFMSK------------------------------- -AEGD------------------------------------------------------- ----------K-------------------------------CEASESINSRDR------ -----------------------------------------AAQERGCS----------- ------------------------------------------------------------ ------------------------------------------------------------ ---------SS------------------------------------------------- --------------------------------SSREL----------------------- --------------TLYLFGRTGREKEEWFQRVLAASK---------------------- -----------------------LKADL-KKASSVSAT---------------------- ------------------------------------------------------------ ----------------------LSCH----------------SRS------------SSR SSLDEVLASQP--RSKDS----SVSSTSAG-N---------------------------- ---AKTKPLLDYTVYMASLL---------------------PE---------------QA VV-------------------SP----AAA-----SPA-L-------------------- ------------------------------------------------------------ ---------QSPHSSPGADKK---L---------Q-STASAQVQPRE---------EEKE ----------EA--TEED-----NVAWVNAALGRVFWDFLSEPYWAELVSKKIQMKLSKI RLPYFMNDLTLTELDMGSATPRILGASKPSIDFRGLWFDLEISYSGSFLMTLETKMNLIR LGKE--GESDRFGEFGKDGYRPRTYCLADSDEESSSAGSSDEEDSSE------------- --------L-STDSA-------GAEGLVGGHKPSKIMRFVDKITKSKYFLKATETEFIKK KMEEVSNTPLLLTVEVQELRGVLAVNIPPPPTDRLWYGFRKPPHLALKARPKLGERVVTL AHVTDWIEKKLDQEFQ-------------------------------------------- ------------------------------------------------------------ --------------------------------------------------KIFVMPNMDD VWLTVMHSAMDPRTAG-------------------------------------------- ----------------------------------GPLVG--------------------- --------------------------------L-SVDPEPS-----------QPEKDST- ---------------------------- >ENSPRNP00000005958 ----------------------------M------------------------------- ------------------------------------------------------------ -------------------------------------------TSQH------------- -----------P-----------------SHANST---------HATDKQP--------- -----------PK-----------------------LHVHRSLSKESITIHFSAFGK-EE EEEE-----------------------E-E--LC-------------------------- ------------------------------------------------------------ ------S-----------------TTVSST-----PAAQ--------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------EDSNIVT--------------ALEASEEM------------------- ----------------------------------FEGLP--------------------- ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------LE------------------DAA GD-----------------------------------GVSA------------------- ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------E-------SSPVS------ ------------------------------------------------------------ ------RHHTNSSPTQTLSSHVSEQKP--------------------------------- ------------------------------------------------------------ --------------------------------------------------------PS-- ---------------------------------------------------------SSP IK-------S-------------------LSFPS-------------------SDKPFLS S---------LVKSLSSD-VESREGSSS----------------------VPAP------ ------PLV-----RHR-HLMKSLVKSLSSDT-SQD----------------SSSS---- -----------SSSSSSFTPYRLPD--SR-LNLQLFKQFTQSR----------MP-SA-- -ATSS--ASD-SKTAPSSPLTSP-DNR---SF-FKVSEVEARIEDTKRRLSEVISEPLQL LSKIMDEKS---SS-LV--------------------------------------S---- SS----------IYRPKVLSASASELSNITSIN-GHVES---NNN-YCIKEEEGGDWEA- D----------------------------------------------------------- --------------------------------------------------------SH-- ------------------------------------N----------------------- ------------------------------------------------------------ ---------------------------------SGGSATAESPVSVSADAKSPNKPSVL- ---------SM------------------SLDKCSMSAL-AKQEDEDFCILYSEDF---- ----------------------------------------------------Y----MEG -DGVDRTEN--------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------AGPGSQTKVPLSGS---------- -TE-------------------------------------------------PYSDDKPE S-----------------------------TEPV-------------------------- --------------------PSVPHYTLIILTVLVYGYFMLPLPSYVGGMLLGIGLGFLL AIGVVWLTGP---------------------------------K---------------- -------------P-SG-GDF-----------RHS---------RHH-------RR---- -----------------LTR-----------------LDIKEPEIYKGWMNEILNYDPET YHATLTQSVYVRLEGSIIRLSKPNHNIARRASHNE--PKPDVSYISQKIYDLNNSKVYLV PHNLARKRIWNKKYPICIELGRQDDFMSK------------------------------- -AEGD------------------------------------------------------- ----------R-------------------------------WE---------------- --------------------------------------------------TGDVT----- ----------------------------------------------SKAEGTGGAQE--R GS---------------------------------------------------------- ------SSSSS------------------------------------------------- --------------------------------SSRDL----------------------- --------------TLYLFGRTGREKEEWFQRLLTASK---------------------- -----------------------LKPDM-KKSSSVVGSKM-------------------- ------------------------------------------------------------ ------------------A---LSCH----------------SRS------------SSR GSLDEA----------------SVSSVTPG-G---------------------------- ---AKSRPLLDYNVYMGSLL---------------------PK---------------QV AV-------------------SP----TAA-----SPA-L-------------------- ------------------------------------------------------------ ---------QSPQSSPGADKK---L---------Q-NTTSAQEQPRG------------- -----------E--DEEE-----TVAWVNAALGRVFWDFLMEPYWAELVSKKIQMKLSKI RLPYFMNELTLTELDMGSATPRILKAYEPYVDNRGLWFDLDVSYSGSFLMTLETKMNLIR LGKE--GDGLRFGEVGKEGYRPRTYCLADSDEESSSAGSSDEEDSSD------------- --------L-SNDSA-------GAEGFVGGHKPSKIMRFVDKITKSKYFQRATETEFIKK KMEEVSNTRLLLTVEVQQLHGTLAVNIPPPPTDRIWYGFRTPPHLELKARPKLGEREVTL AHVTDWIEKKLDQEFQ-------------------------------------------- ------------------------------------------------------------ --------------------------------------------------KILVMPNMDD VWLTIMHSAMDPRTAC-------------------------------------------- ----------------------------------GPLVA--------------------- --------------------------------P-SADSEPS-----------QPETDGTG -QP------------------------- >ENSLBEP00000002012 ----------------------------M------------------------------- ------------------------------------------------------------ -------------------------------------------TSKH------------- -----------H-----------------SHAESA---------HSTEKKP--------S --------TASPK-----------------------LHVQRSLSKENITIHFSALGK-EE EEEE-----------------------E-E--LY-------------------------- ------------------------------------------------------------ ------I-----------------TSVSAT-----SAIR--------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------NDSNIVT--------------ALEASEEM------------------- ----------------------------------FEGV---------------------- ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------TPD-SRL---------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------------SLVS------ ------------------------------------------------------------ ------RKHTDSLPTDTPSLDVAENKG--------------------------------- ------------------------------------------------------------ ------------------------------------------------------STSS-- ---------------------------------------------------------SSP SK-------S-------------------SSFPS-------------------SDKPFL- S---------LVKSLSSD-METCEGIPS----------------------VAAP------ ------T-V-----RHR-HLMKNFVKSLSSDT-SQD--------------TSSSST---- -----------SSS----TPYRLPE--SR-LNLQLFKQFTQSR-------------SG-- -GTSS--ASD-SKTAPSSPLTSP-DNR---SF-FKVSEVEARIEDTKRRLSEAISEPLQL LSKIIDERS---SS-LS--------------------------------------S---- SS----------LYRPKALSASATELSNISSVN-GHPES---NNN-YCIKEEEGGDWEA- E----------------------------------------------------------- --------------------------------------------------------SP-- ------------------------------------N--------------S-------- ------HAP--------------AELP--------------------------------- -----------------------------DPP--------------SADTECPNKPSSL- ---------SM------------------SLDKCSMSAL-AKQEDEDFCILYNKDF---- ----------------------------------------------------DICTETDG -EG-DRTLD--------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------SGSGSPTKVPLSGS---------- -TE-------------------------------------------------PCSEDESQ S-----------------------------IEPA-------------------------- --------------------PSVPHYTLIILTLVVYGCFVLPLPTYVGGVLLGIALGFLL AIGVVWLTGP---------------------------------K---------------- -------------P-SD-RRF-----------RHS---------RFH-------GKFW-- ----------------NLNK-----------------LDIKEPEIYKGWMNEISNYDPET YHATLTQSVFVRLEGSIIRLSKPNHNIARRATHNE--PKPDVTYISQKIYDLTNSKVYVV PQSLARKRVWNKKYPICIELSKQDDFMSK------------------------------- -AEGD------------------------------------------------------- ----------R-------------------------------WEPSESPSTRDRGE---- ------------------------------------------------------------ --------------------------------------------------GAGGAQD--R R----------------------------------------------------------- ---------SS------------------------------------------------- --------------------------------SSRDL----------------------- --------------TLYLFGRTGREKEEWFQRFLSASK---------------------- -----------------------LKADL-KKATGVAVCKS-------------------- ------------------------------------------------------------ ------------------APTVLNSH----------------SRS------------SSR GSLDE-LASQP--KSKDS----SASSSTAG-I---------------------------- ---AKAKPLLDYSVYMASML---------------------PN---------------QA AV-------------------SP----AAT-----SPA-P-------------------- ------------------------------------------------------------ ---------QSPQSSPGSDKK---L---------Q-STTSAPVQPCV------------- -----------E--EEDD-----NVAWVNAALGRVFWDFLSEPHWAELVSNKIQMKLSKI RLPYFMNELTLTELDMGSATPRILRASKPSIDYRGLWFDLELSYSGSFLMTLETKMNLIR LGKE--GESVRLGEFGKDGYRPRTYCLADSDEESSSAGSSDEEDMSE------------- --------L-SNDSA-------GAEGFVGGHKPSKIMRFVDKITKSKYFQKATETEFIKK KMEEVSNTPLLLTVELQELQGTLAVNIPPPPTDRIWYGFRTPPHLELKARPKLGERKVTL AHVTDWIEKKLDQEFQ-------------------------------------------- ------------------------------------------------------------ --------------------------------------------------KIFVMPNMDD IWLTIMHSAMDSRTAG-------------------------------------------- ----------------------------------GPLMV--------------------- --------------------------------P-AVDPEPP-----------QPEKECPS -QL------------------------- >ENSBSLP00000035121 ----------------------------M------------------------------- ------------------------------------------------------------ -------------------------------------------TSRQ------------- -----------F-----------------SHASSA---------HDPDKPP--------P --------TLAPK-----------------------LHVHRSPSKDTITIRFSAFGK-EE EDEE-----------------------E-E--LY-------------------------- ------------------------------------------------------------ ------C-----------------TTAPSI-----PVTQ--------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------DDSNVVT--------------AVEANEEM------------------- ----------------------------------FQGSSLD------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------VAAEVPVDLESSRL---------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------------TPLS------ ------------------------------------------------------------ ------RHRTNDAPTQTFSANIVEQKG--------------------------------- ------------------------------------------------------------ ------------------------------------------------------STSN-- ---------------------------------------------------------ASP SK-------S-------------------LSFPS-------------------SDKPFL- S---------LVKSISSD-AEARDGVSS----------------------VPAP------ ------T-V-----RHR-HLMKTLVKSLSSDT-SQD----------------SSFS---- ------------------APYRLSE--SR-LNLQLFRQF--------------IP-SA-- -TVST--AVD-SKTAPSSPLTSP-DNR---SF-FKVSDVEARIEDTKRRFSEVISEPFQL LTKIMDEKS---G----------------------------------------------- SN----------IYRPKTLSASASELTS-EAIN-GHLES--NNNN-YCIKEEEGGEWEA- E----------------------------------------------------------- --------------------------------------------------------SP-- ------------------------------------NCRSS---------VS-------- ------------------------------------------------------------ -------------------------------LES---------VSSSVNTKSPSKSLSL- ---------SM------------------SLDKCSMSAL-AKQEDEDFCILYSDDF---- ----------------------------------------------------ETCTDTEG -DGANRTDE--------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------SGTDSQIKMPVSGS---------- -TE-------------------------------------------------PCSEDELE N-----------------------------VELV-------------------------- --------------------PSVPYYTLVALTVLVYGYFVLPLPSYFGGMLLGIGLGFLV AIGVVWLTGPNS----------------------SKTYFRCDR----------------- -------------------------------------------------------KLS-- ----------------NITR-----------------LDIKEPEIYKGWMNEISNYDPET YHATLTHSVYVRLEGSVIRLSKPNHNIARRATHNE--PKPDVTYISQKIYDLTNSKVYLV PNSLARKRVWNKKYPVCIELAKQDGFMSK------------------------------- -AEGH------------------------------------------------------- ----------R-------------------------------WEASEG------------ ------------------------------------------------------TS---- -------------L-------------------------------TSREDGSGGTLE--K G----------------------------------------------------------- -------ASAS------------------------------------------------- --------------------------------SSRDV----------------------- --------------TLYLFGRTGREKEEWFQRFLSASK---------------------- -----------------------HKTSL-KKTTSFAGIKS-------------------- ------------------------------------------------------------ ------------------A---QSSH----------------SRS------------SSR SSLDETLVPQP--KSKDP----SVSSAVAG-N---------------------------- ---AKAKLPFDYSVYMASIL---------------------PE---------------QA AV-------------------SS----VAT-----SPF-V-------------------- ------------------------------------------------------------ ---------QSPQNSPGADKK---F---------Q-TTTSSQAHPR-------------- --------------EEDE-----AVAWVNAALGRVFWDFLTEPHWAEVVSKKIQMKLSKI RLPYFMNELTLNELDMGSVTPRILGASKPSIDYRGLWFDLEISYSGSFLMTLETKMNLIR LGKE--GEGARIGDLGKEGYRPRTYCLADSDEESSSAGSSDEEDSSG------------- --------V-SNESV-------GAEGLVGGHKPSKIMRFVDKIAKSKYFQKATETEFIKK KMEEVSNTPLLLTVELQELQGTLAVNIPPPPTDRIWYGFRTPPHLEFKARPKLGEREVTL AHVTDWIEKKLDQEFQ-------------------------------------------- ------------------------------------------------------------ --------------------------------------------------KIFVMPNMDD VWLTVMHSAMDPRTAG-------------------------------------------- ----------------------------------GPLVS--------------------- --------------------------------P-PVDSEAS-----------QEERESTT -PP------------------------- >ENSHBUP00000011214 ----------------------------MLSCFTGPCKIIINIMTTLVPILVHIAPPSII LMLTPTVKAYILPYGYIPSTNGYQLNAELRRTHSLYILGLCVYIFYSHNYLWPFNSCVSQ KPHEHHGHVILDSALGRCKSQAGLNGTEDTS-------GSIEMTSRH------------- -----------P-----------------GHGEST---------HSTDKQP--------P --------AFTPR-----------------------LHVQRPLSKENIAIHFSALGK-EE EEEE-----------------------E-E--LY-------------------------- ------------------------------------------------------------ ------C-----------------TTVSTP-----SAAM--------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------YDSDIVT--------------ALEASEEM------------------- ----------------------------------FDGVPSG------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------SAAGAGVIPETSRL---------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------------SSPS------ ------------------------------------------------------------ ------RHHTINSTTQTLSS------A--------------------------------- ------------------------------------------------------------ ------------------------------------------------------STSN-- ---------------------------------------------------------SSP TK-------S-------------------LSFPS-------------------SDKPFL- S---------LAKSISSD-AESRDGVSS----------------------IPAP------ ------S-L-----RHT-HLMKTLVKSLSSDT-SQD----------------LSSS---- -----------SAS------YRLPE--SR-LNLQLFKQFAQSR----------LS-SA-- -AMSS--ASD-SKTAPSSPLTSP-DNR---SF-FKVSEVEARIEDTKRRLSEAISEPLQL LSKIMDEKS---GN-LV--------------------------------------G---- SS----------IYRPKVLSASATELSSLGSIN-GPMET---NNN-YCIKEEEGTDWEG- E----------------------------------------------------------- --------------------------------------------------------SP-- ------------------------------------N----------------------- --------RQASASAESPLSTAFA------------------------------------ -------------------------------------------------TKSPSKSSLL- ----------------------------------YMSAL-AKQAEEDYCILSNEEF---- ----------------------------------------------------ETFTDTEG -ESVDKTDN--------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------TGTGSLTKVPLSGS---------- -TE-------------------------------------------------PCSEDESE Y-----------------------------IEPL-------------------------- --------------------PSVPYYTLIILTLLLYGCFILPLPSYIGGVLLGIELGFLL AIGFVWLAGP---------------------------------K---------------- -------------R-SG-G--------------------NNMGLRRH-------GKLL-- ----------------NVTK-----------------LDIKEPDIYKGWMNEIQNYDPET YHATLTQSVFVRLEGSIIRLSKPNHNIARRASHNE--PKPDVKYISQKIYDLTYSKVYLV PHGLARKRVWNKKYPICIELGRQDDFMSK------------------------------- -AEGE------------------------------------------------------- ----------R-------------------------------MEASEG--TRERGE---- ------------------------------------------------------------ --------------------------------------------------GTGAFQE--R R----------------------------------------------------------- ------SSSSS------------------------------------------------- --------------------------------SSSIL----------------------- --------------TLYLFGRTGRDKEEWFQRFLSASK---------------------- -----------------------LKVGL-KKSSSVVGLKK-------------------- ------------------------------------------------------------ ------------------A---LSCH----------------SRN------------SSR SSLDEALTSQT--KSKDS----SVSSTTVG-S---------------------------- ---AKTKPLLDYSVYMGSLM---------------------PK---------------ES AV-------------------SP----TAA-----SPV-L-------------------- ------------------------------------------------------------ ---------QSPQSSPGADKK---L---------Q-STTSAQVQPDG------------- --------------EADD-----SVAWVNATVGRLFWDFLTEPYWIEQVSKKIQMKLSKI RLPYFMNELTLTELDMGSTTPRILRASKPCINYRGLWFDLEMTYSGSFLMTLETKMNLIR LGKE--GESLRPGEFGKDGYRPRTYCLADSDEESSSAGSSDEEDSSD------------- --------V-SNDLT-------GAEGFVGGHKSSKIMRFVDKITKSKYFQKATETEFIKK KMEEVSNTPLLLTVEVQELQGTLAVNIPPPPTDRIWYGFRTPPHLELKARPKLGEREVTL AHVTDWIEKKLKQEFE-------------------------------------------- ------------------------------------------------------------ --------------------------------------------------KILVMPNMDD VWLPIMHSAMDPRTAG-------------------------------------------- ----------------------------------GPLVG--------------------- --------------------------------P-PVDPEPS-----------QPERESTS -QP------------------------- >ENSACLP00000018555 ----------------------------MLSCFTGPCKIIINIMTTLVPILVHIAPPSII LMLTPTVKAYILPYGYIPSTNGYQLNAELRRTHSLYILGLCVYIFYSHNYLWPFNSCVSQ KPHEHHGHVILDSALGRCKSQAGLNGTEDTS-------GSIEMTSRH------------- -----------P-----------------GHGEST---------HSTDKQP--------P --------AFTPR-----------------------LHVQRPLSKENIAIHFSALGK-EE EEEE-----------------------E-E--LY-------------------------- ------------------------------------------------------------ ------C-----------------TTVSTP-----SAAM--------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------YDSDIVT--------------ALEASEEM------------------- ----------------------------------FDGVPSG------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------SAAGAGVIPETSRL---------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------------SSPS------ ------------------------------------------------------------ ------RHHTINSTTQTLSS------A--------------------------------- ------------------------------------------------------------ ------------------------------------------------------STSN-- ---------------------------------------------------------SSP TK-------S-------------------LSFPS-------------------SDKPFL- S---------LAKSISSD-AESRDGVSS----------------------IPAP------ ------S-L-----RHT-HLMKTLVKSLSSDT-SQD----------------LSSS---- -----------SAS------YRLPE--SR-LNLQLFKQFAQSR----------LS-SA-- -AMSS--ASD-SKTAPSSPLTSP-DNR---SF-FKVSEVEARIEDTKRRLSEAISEPLQL LSKIMDEKS---GN-LV--------------------------------------G---- SS----------IYRPKVLSASATELSSLGSIN-GPMET---NNN-YCIKEEEGTEWEG- E----------------------------------------------------------- --------------------------------------------------------SP-- ------------------------------------S----------------------- --------RQASASAESPLSTAFA------------------------------------ -------------------------------------------------TKSPSKSSLL- ----------------------------------YMSAL-AKQAEEDYCILSNEEF---- ----------------------------------------------------ETFTDTEG -ESVDKTDN--------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------TGTGSLTKVPLSGS---------- -TE-------------------------------------------------PCSEDESE Y-----------------------------IEPL-------------------------- --------------------PSVPYYTLIILTLLLYGCFILPLPSYIGGVLLGIELGFLL AIGFVWLAGP---------------------------------K---------------- -------------R-SG-G--------------------NNMGPRRH-------GKLL-- ----------------NVTK-----------------LDIKEPDIYKGWMNEIQNYDPET YHATLTQSVFVRLEGSIIRLSKPNHNIARRASHNE--PKPDVNYISQKIYDLTYSKVYLV PQGLARKRVWNKKYPICIELGRQDDFMSK------------------------------- -AEGE------------------------------------------------------- ----------R-------------------------------MEASEG--TRERGE---- ------------------------------------------------------------ --------------------------------------------------GTGAFQE--R R----------------------------------------------------------- ------SSSSS------------------------------------------------- --------------------------------SSSIL----------------------- --------------TLYLFGRTGRDKEEWFQRFLSASK---------------------- -----------------------LKVGL-KKSSSVVGLKK-------------------- ------------------------------------------------------------ ------------------A---LSCH----------------SRN------------SSR SSLDEALTSQT--KSKDS----SVSSTTVG-S---------------------------- ---AKTKPLLDYSVYMGSLM---------------------PK---------------ES AV-------------------SP----TAA-----SPV-L-------------------- ------------------------------------------------------------ ---------QSPQSSPGADKK---L---------Q-STTSAQVQPDG------------- --------------EEDD-----SVAWVNATVGRLFWDFLTEPYWIEQVSKKIQMKLSKI RLPYFMNELTLTELDMGSTTPRILRASKPCINYRGLWFDLEMTYSGSFLMTLETKMNLIR LGKE--GESLRPGEFGKDGYRPRTYCLADSDEESSSAGSSDEEDSSD------------- --------V-SNDLT-------GAEGFVGGHKSSKIMRFVDKITKSKYFQKATETEFIKK KMEEVSNTPLLLTVEVQELQGTLAVNIPPPPTDRIWYGFRTPPHLELKARPKLGEREVTL AHVTDWIEKKLKQEFE-------------------------------------------- ------------------------------------------------------------ --------------------------------------------------KILVMPNMDD VWLPIMHSAMDPRTAG-------------------------------------------- ----------------------------------GPLVG--------------------- --------------------------------P-PVDPEPS-----------QPERESTS -QP------------------------- >ENSMZEP00005014976 ----------------------------MLSCFTGPCKIIINIMTTLVPILVHIAPPSII LMLTPTVKAYILPYGYIPSTNGYQLNAELRRTHSLYILGLCVYIFYSHNYLWPFNSCVSQ KPHEHHGHVILDSALGRCKSQAGLNGTEDTS-------GSIEMTSRH------------- -----------P-----------------GHGEST---------HSTDKQP--------P --------AFTPR-----------------------LHVQRPLSKENIAIHFSALGK-EE EEEE-----------------------E-E--LY-------------------------- ------------------------------------------------------------ ------C-----------------TTVSTP-----SAAM--------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------YDSDIVT--------------ALEASEEM------------------- ----------------------------------FDGVPSG------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------SAAGAGVIPETSRL---------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------------SSPS------ ------------------------------------------------------------ ------RHHTINSTTQTLSS------A--------------------------------- ------------------------------------------------------------ ------------------------------------------------------STSN-- ---------------------------------------------------------SSP TK-------S-------------------LSFPS-------------------SDKPFL- S---------LAKSISSD-AESRDGVSS----------------------IPAP------ ------S-L-----RHT-HLMKTLVKSLSSDT-SQD----------------LSSS---- -----------SAS------YRLPE--SR-LNLQLFKQFAQSR----------LS-SA-- -AMSS--ASD-SKTAPSSPLTSP-DNR---SF-FKVSEVEARIEDTKRRLSEAISEPLQL LSKIMDEKS---GN-LV--------------------------------------G---- SS----------IYRPKVLSASATELSSLGSIN-GPMET---NNN-YCIKEEEGTEWEG- E----------------------------------------------------------- --------------------------------------------------------SP-- ------------------------------------S----------------------- --------RQASASAESPLSTAFA------------------------------------ -------------------------------------------------TKSPSKSSLL- ----------------------------------YMSAL-AKQAEEDYCILSNEEF---- ----------------------------------------------------ETFTDTEG -ESVDKTDN--------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------TGTGSLTKVPLSGS---------- -TE-------------------------------------------------PCSEDESE Y-----------------------------IEPL-------------------------- --------------------PSVPYYTLIILTLLLYGCFILPLPSYIGGVLLGIELGFLL AIGFVWLAGP---------------------------------K---------------- -------------R-SG-G--------------------NNMGPRRH-------GKLL-- ----------------NVTK-----------------LDIKEPDIYKGWMNEIQNYDPET YHATLTQSVFVRLEGSIIRLSKPNHNIARRASHNE--PKPDVNYISQKIYDLTYSKVYLV PQGLARKRVWNKKYPICIELGRQDDFMSK------------------------------- -AEGE------------------------------------------------------- ----------R-------------------------------MEASEG--TRERGE---- ------------------------------------------------------------ --------------------------------------------------GTGAFQE--R R----------------------------------------------------------- ------SSSSS------------------------------------------------- --------------------------------SSSIL----------------------- --------------TLYLFGRTGRDKEEWFQRFLSASK---------------------- -----------------------LKVGL-KKSSSVVGLKK-------------------- ------------------------------------------------------------ ------------------A---LSCH----------------SRN------------SSR SSLDEALTSQT--KSKDS----SVSSTTVG-S---------------------------- ---AKTKPLLDYSVYMGSLM---------------------PK---------------ES AV-------------------SP----TAA-----SPV-L-------------------- ------------------------------------------------------------ ---------QSPQSSPGADKK---L---------Q-STTSAQVQPDG------------- --------------EEDD-----SVAWVNATVGRLFWDFLTEPYWIEQVSKKIQMKLSKI RLPYFMNELTLTELDMGSTTPRILRASKPCINYRGLWFDLEMTYSGSFLMTLETKMNLIR LGKE--GESLRPGEFGKDGYRPRTYCLADSDEESSSAGSSDEEDSSD------------- --------V-SNDLT-------GAEGFVGGHKSSKIMRFVDKITKSKYFQKATETEFIKK KMEEVSNTPLLLTVEVQELQGTLAVNIPPPPTDRIWYGFRTPPHLELKARPKLGEREVTL AHVTDWIEKKLKQEFE-------------------------------------------- ------------------------------------------------------------ --------------------------------------------------KILVMPNMDD VWLPIMHSAMDPRTAG-------------------------------------------- ----------------------------------GPLVG--------------------- --------------------------------P-PVDPEPS-----------QPERESTS -QP------------------------- >ENSNBRP00000023373 ----------------------------M------------------------------- ------------------------------------------------------------ ------------------------------SFQDRAASGSIEMASRH------------- -----------P-----------------GHGEST---------HSTDKQP--------P --------AFTPR-----------------------LHVQRPLSKENIAIHFSALGK-EE EEEE-----------------------E-E--LY-------------------------- ------------------------------------------------------------ ------C-----------------TTVSTP-----SAAM--------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------YDSDIVT--------------ALEASEEM------------------- ----------------------------------FDGVPSA------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------SAAGAGVIPETSRL---------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------------SSPS------ ------------------------------------------------------------ ------RHHTINSTTQTLSS------A--------------------------------- ------------------------------------------------------------ ------------------------------------------------------STSN-- ---------------------------------------------------------SSP TK-------S-------------------LSFPS-------------------SDKPFL- S---------LTKSISSD-AESRDGVSS----------------------IPAP------ ------S-L-----RHT-HLMKSLVKSLSSDT-SQD----------------LSSS---- -----------SGS------HRLPE--SR-LNLQLFKQFAQSR----------LS-SA-- -ATSS--ASD-SKTAPSSPLTSP-DNR---SF-FKVSEVEARIEDTKRRLSEAISEPLQL LSKIMDEKS---GN-LV--------------------------------------G---- SS----------IYRPKVLSASATELSSLGSIN-GPMET---NNN-YCIKEEEGTDWEG- E----------------------------------------------------------- --------------------------------------------------------SP-- ------------------------------------S----------------------- --------RQASASAESPLSTAFA------------------------------------ -------------------------------------------------TKSPSKSSLL- ----------------------------------YMSAL-AKQEEEDYCILSNEEF---- ----------------------------------------------------ETFTDTEG -DGVDKTDN--------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------TGTGSLTKVPLSGS---------- -TE-------------------------------------------------PCSEDESE Y-----------------------------IEPL-------------------------- --------------------PSVPYYTLIILTLLLYGCFILPLPSYIGGVLLGIELGFLI AIGFVWLAGP---------------------------------K---------------- -------------R-SG-G--------------------NNMGPRRH-------GKLL-- ----------------NATK-----------------LDIKEPDIYKGWMNEIQNYDPET YHATLTQSVFVRLEGSIIRLSKPNHNIARRASHNE--PKPDVNYISQKIYDLTYSKVYLV PQGLARKRVWNKKYPICIELGRQDDFMSK------------------------------- -AEGE------------------------------------------------------- ----------R-------------------------------MEASEG--TRERGE---- ------------------------------------------------------------ --------------------------------------------------GTGAFQE--C R----------------------------------------------------------- -------SSSS------------------------------------------------- --------------------------------SSSIL----------------------- --------------TLYLFGRTGRDKEEWFQRFLSASK---------------------- -----------------------LKVGL-KKSSSVVGLKK-------------------- ------------------------------------------------------------ ------------------A---LSCH----------------SRS------------SSR SSLDEALTSQT--KSKDS----SVSSTTVG-S---------------------------- ---AKTKPLLDYSVYMGSLM---------------------PK---------------ES AV-------------------SP----TAA-----SPV-L-------------------- ------------------------------------------------------------ ---------QSPQSSPGADKK---L---------Q-STTSAQVQPDG------------- --------------EEDD-----SVAWVNATVGRLFWDFLTEPYWIEQVSKKIQMKLSKI RLPYFMNELTLTELDMGSTTPRILRASKPCINYRGLWFDLEMTYSGSFLMTLETKMNLIR LGKE--GESLRPGEFGKDGYRPRTYCLADSDEESSSAGSSDEEDSSD------------- --------V-SNDLT-------GAEGFVGGHKSSKIMRFVDKITKSKYFQKATETEFIKK KMEEVSNTPLLLTVEVQELQGTLAVNIPPPPTDRIWYGFRTPPHLELKARPKLGEREVTL AHVTDWIEKKLKQEFE-------------------------------------------- ------------------------------------------------------------ --------------------------------------------------KILVMPNMDD VWLLIMHSAMDPRTAG-------------------------------------------- ----------------------------------GPLVG--------------------- --------------------------------P-PVDPEPS-----------QPERESTS -QP------------------------- >ENSONIP00000004325 ----------------------------M------------------------------- ------------------------------------------------------------ -------------------------------------------TSRH------------- -----------P-----------------GHGEST---------HSTDKQP--------P --------AFTPR-----------------------LHVQRPLSKENITIHFSTLGK-EE EEEE-----------------------E-E--LY-------------------------- ------------------------------------------------------------ ------C-----------------TTVSTP-----SAAM--------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------YDSDIVT--------------ALEASEEM------------------- ----------------------------------FDGVPSA------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------SAAGAGVIPETSRL---------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------------SSPS------ ------------------------------------------------------------ ------RHHTINSPAQTLSS------A--------------------------------- ------------------------------------------------------------ ------------------------------------------------------STSN-- ---------------------------------------------------------SSP TK-------S-------------------LSFPS-------------------SDKPFL- S---------LVKSISSD-AESRDGVSS----------------------IPTP------ ------S-V-----RRR-HLMKTLVKSLSSDT-SQD----------------SSSS---- -----------SAS------YRLPE--SR-LNLQLFKQFAQSR----------MS-SA-- -VMSS--ASD-SKTAPSSPLTSP-DNR---SF-FKVSEVEARIEDTKRRLSEAISEPLQL LSKIMDEKS---GN-LV--------------------------------------G---- SS----------IYRPKVLSASATELSSLGSIN-GQMET---NNN-YCIKEEEGTDWED- E----------------------------------------------------------- --------------------------------------------------------SP-- ------------------------------------S----------------------- --------RQASASAESPLSTAFA------------------------------------ -------------------------------------------------TKSPSKSSLL- ----------------------------------FMSAL-AKQEEEEYCILSNEEF---- ----------------------------------------------------ETCTDTEG -DGVDKTDI--------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------TGTGSLTKVPLSGS---------- -TE-------------------------------------------------PCSEDESE Y-----------------------------IEPL-------------------------- --------------------PSVPYYTLIILTVLLYGCFILPLPSYIGGVLLGIELGFLL AIGFVWLAGP---------------------------------K---------------- -------------R-SG-G--------------------NNMG--RH-------GKLL-- ----------------DVTK-----------------LDIKEPDIYKGWMNEIQNYDPET YHATLTQSVYVRLEGSIIRLSKPNHNIARRASHNE--PKPDVNYISQKIYDLTYSKVYLV PQSLARKRVWNKKYPICIELGRQDDFMSK------------------------------- -AEGE------------------------------------------------------- ----------R-------------------------------MEASEG--TRERGE---- ------------------------------------------------------------ --------------------------------------------------GTGASQE--R R----------------------------------------------------------- -------SSSS------------------------------------------------- --------------------------------FSPIL----------------------- --------------TLYLFGRTGRDKEEWFQRFLSASK---------------------- -----------------------LKVGL-KKSSSVVGIKKG------EIQLC-------- ---------------------------SY-----------S-------------RNSST- ----L-------------S---LSCH----------------SRN------------SSR SSLDEVLTSQT--RSKDS----SVSSTTVG-S---------------------------- ---AKTKPLLDYSVYMGSLM---------------------PK---------------ES AV-------------------SP----TAA-----SPV-L-------------------- ------------------------------------------------------------ ---------QSPQSSPGADKK---L---------Q-STTSAQVQPGG------------- --------------EEDD-----SVAWVNATVGRIFWDFLNEPYWIEQVSKKIQMKLSKI RLPYFMNELTLTELDMGSTTPRILRASKPCINYRGLWFDLEMTYSGSFLMTLETKMNLIR LGKE--GESLRPGEFGKDGYRPRTYCLADSDEESSSAGSSDEEDSSD------------- --------V-SNDST-------GAEGFVGGHKSSKIMRFVDKITKSKYFQKATETEFIKK KMEEVSNTPLLLTVEVQELQGTLAVNIPPPPTDRIWYGFRTPPHLELKARPKLGEREVTL AHVTDWIEKKLKQEFE-------------------------------------------- ------------------------------------------------------------ --------------------------------------------------KILVMPNMDD VWLPIMHSAMDPRTAG-------------------------------------------- ----------------------------------GPLVG--------------------- --------------------------------P-LVDPEP-------------------S -QP------------------------- >ENSACIP00000031287 ----------------------------M------------------------------- ------------------------------------------------------------ -------------------------------------------TSRH------------- -----------P-----------------SHAEST---------HSTDKQP--------P --------AIAPR-----------------------LHVQQSLSKENITIHFSALGK-EE EEEE-----------------------E-E--LY-------------------------- ------------------------------------------------------------ ------C-----------------TTVSTP-----SAAM--------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------YDSDVVT--------------ALEASEEM------------------- ----------------------------------FEAVPSA------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------SAA----IPETPRL---------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------------SAPS------ ------------------------------------------------------------ ------RYHTMNSLTQTLSS------A--------------------------------- ------------------------------------------------------------ ------------------------------------------------------STSN-- ---------------------------------------------------------SSP TK-------S-------------------LSFPS-------------------SDKPFL- S---------LMKSASSE-AESRDGASS----------------------VPAS------ ------S-V-----RHR-HLMKTLVKSLSSDT-SQD----------------SSSS---- -----------STS------YRLPE--SR-LNLQLFKQFAQSR----------IS-SA-- -AVSS--AID-SKTAPSSPLTSP-DNR---SF-FKVSEVEARIEDTKRRLSEAISEPLQL LSKIMDEKS---GN-LV--------------------------------------G---- SS----------IYRPKVLSASATELSSLGSIN-GQMET---NNN-YCIKEEEGADCEA- E----------------------------------------------------------- --------------------------------------------------------SP-- ------------------------------------S----------------------- --------RQTPASTESPVSTAFD------------------------------------ -------------------------------------------------TKSPIKSSLL- ----------------------------------SMSAL-AKQEDEDYCILYNEDF---- ----------------------------------------------------DTCTDTEG -DGVDRTDN--------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------TGTGSPTKVPLSGS---------- -TE-------------------------------------------------LCSEDESE S-----------------------------TEPV-------------------------- --------------------PSVPHYTLIILTVLVYGCFLLPLPSSIGGMLLGIELGFLL AIGFLWLAGP---------------------------------K---------------- -------------P-SG-GSS-----------VRRRHNR----------------KLF-- ----------------NVTK-----------------LDIKEPDIYKGWMNEIQNYDPET YHATLTHSVYVRLEGSTIRLSKPNHNIARRASHNE--PKPDVNYVSQKIYDLTNSKVYLV PPNLARKRIWNKKYPICIELGRQDDFMSK------------------------------- -AEGE------------------------------------------------------- ----------R-------------------------------MDASEGMSTREKGE---- ------------------------------------------------------------ --------------------------------------------------GMGAAQE--R G----------------------------------------------------------- ------SSSSS------------------------------------------------- --------------------------------SSRDL----------------------- --------------TLFLFGRTGREKEEWFQRFLSASK---------------------- -----------------------LKVGL-KKSS--------------------------- ------------------------------------------------------------ ------------------T---LSSH----------------SRN------------SSR SSLDEALTSQT--KSKDS----SVSSTTTG-S---------------------------- ---PKTKPLLDYSGYMGSLM---------------------PK---------------DS AV-------------------SP----TAA-----SPV-L-------------------- ------------------------------------------------------------ ---------QSPQSSPGADKK--------------------------------------- ---------------EED-----SVAWVNAAVGRLFWDFLTEPYWIEQVSKKIQMKLSKI RLPYFMNELTLTELDMGSTTPRILRASKPCINYRGLWFDLEMSYSGSFLMTLETKMNLIR LGKE--GESLRPGEFGKDG--PRTYCLADSDEESSSAGSSDEEDSSD------------- --------V-SNDST-------AAEGFVGGHKPSKIMRFVDKITKSKYFQKATETEFIKK KMEEVSNTPLLLTVEVQELRGTLAVNIPPPPTDRLWYGFRTPPHLELKARPKLGEREVTL AHVTDWIEKKLEQEFQ-------------------------------------------- ------------------------------------------------------------ --------------------------------------------------KILVMPNMDD VWLTIMHSAMDPRTAG-------------------------------------------- ----------------------------------GPLVGE-------STLEKA------- -----QIL--------------------DVYL---------------------------- --P------------------------- >ENSKMAP00000027559 ----------------------------M------------------------------- ------------------------------------------------------------ -------------------------------------------TSQH------------- -----------P-----------------SHAES-----------SSDKQL--------P --------AGGPR-----------------------LHVQGSLSKENVTVHFS-LGK-EE EEEE-----------------------E-E--LY-------------------------- ------------------------------------------------------------ ------I-----------------TSVSTN-----SVAM--------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------KDLNVAT--------------AVEASEDM------------------- ----------------------------------FEGDPVD------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------SAAEVAVVSESSRL---------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------------SPSS------ ------------------------------------------------------------ ------RNHTNRSPTHTLSSRVPEQKP--------------------------------- ------------------------------------------------------------ ------------------------------------------------------STVT-- ---------------------------------------------------------SSP IK-------S-------------------LSFSS-------------------SDKSFL- S---------MVKSLSSD-VESHDGLSA-----------------------PAP------ ------S-V-----RHR-PLMKNLVKSFSSDT-SQD----------------PPSS---- -----------TTS------SRLPE--SR-LNLQLFKQFAQSR----------MP-PA-- -AVTS--VSD-SKTAPCSPLTSP-DNR---SF-FKVSEVEARFEDTKRRLTEAISEPLQM LSKIMDEKS---GG-LV--------------------------------------G---- SS----------IYRPKVLSASATELSTLASIS-DHLES---NNN-YCIKEEEG-DLEA- E----------------------------------------------------------- --------------------------------------------------------SP-- ------------------------------------N--------------SWTSVTADP PSDPPAN----------------------------------------------------- -------------------------------------------------TKSPTKSSSL- ----------------------------------SMSTL-VKQEDEDFCILNSEDF---- ----------------------------------------------------ETCTDTEG ------------------------------------------------------------ SDGVTPTGSQALLSDSSDPNC--------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------D------------------------- --------------------------------------------------------DECE D-----------------------------TEPA-------------------------- --------------------PSVPYYTLVVLTVLVYGCFVLPLPSYVGGVLLGIGLGFFL AIGVVWLTGP---------------------------------K---------------- -------------R-SG-DEV-----------RHS---------RNQ-------GKLW-- ----------------NIAK-----------------LDIKEPEIYKGWMNEILNYDPET YHATLTQSVYVRLEGSIIRLSKPNHNIARRATHKE--QKPDVTYVSQKIYDLTNSKVYLV PQNLARKRVWNKKYPICIELAKQDNFMSK------------------------------- -TEG-------------------------------------------------------- ---------------------------------------------------------AGG N------------------QSTSPREYRAQERQSPPFSRKR------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------L----------------------- --------------TLYLFGRTGRDKEEWFQRFLSASN---------------------- -----------------------VMVDL-KKTSCAGSSKK-------------------- ------------------------------------------------------------ ------------------A---SNSH----------------SRS------------SSR SSLNEVLASQL--KSKDS----AASSTTAG-S---------------------------- ---AKSKSPLDYTIYMGSLL---------------------PK---------------QL AV-------------------SP----TAA-----SSA---------------------- ------------------------------------------------------------ ---------SSLQSSPGAEKK---L---------Q-GTTAAQVQPQG------------- ----------EE--EEED-----TVAWVNAALGRLFWDFLTEPYWAEVVSKKIQMKLSKI RLPYFMNELTLTELDMGSAIPRILGASAPSMDYQGLWFDLEISYSGSFLMTLETKMILNR LGKE--GESLRLGEFGKDG--PRTYCLAASDEESSSAGSSDEEDASD------------- --------V-SSDST-------GAEGFVGGHKSSKIMRFVDKIAKSKYFQKATETEFIKK KMEEVSNTPLLLTVELQQLRGRLAVNIPPPPTDRIWYGFRTPPRLELKARPKLGEREVTL AHVTDWIEKKLEQEFQ-------------------------------------------- ------------------------------------------------------------ --------------------------------------------------KILVMPNMDD VWLTIMHSAMDPRTAG-------------------------------------------- ----------------------------------GPLVC--------------------- --------------------------------P-SPNAEPS------------------- ---------------------------- >ENSPLAP00000018527 ----------------------------M------------------------------- ------------------------------------------------------------ -------------------------------------------TSQY------------- -----------P-----------------SHG--A---------KSTDKKP--------S --------VVAPK-----------------------LHVQRSPSKEAITIHFSALGK-ED EEEE-----------------------E-G--LF-------------------------- ------------------------------------------------------------ ------I-----------------SACPTA-----SAPL--------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------DDSNIVT--------------ALEASEEM------------------- ----------------------------------FDGASLD------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------SAASGAVIPEYSKF---------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------------SPSS------ ------------------------------------------------------------ ------TNHTNRSPTQTLSSHVPEQKA--------------------------------- ------------------------------------------------------------ ------------------------------------------------------SSAS-- ---------------------------------------------------------SSP IK-------S-------------------LSFPS-------------------T----L- G---------WGKSSSSD-IESGEGPSS----------------------ALTS------ ------S-V-----RHR-QLMKNLVKSLSSDT-SQD----------------SSSS---- -----------STS------YRLPD--SR-LNLNLLKQFAQSR----------MP-SV-- -AVAS--VND-SKTAPSSPLTSP-DNR---SF-FKVSDVEARFGDTKRRLTEAISEPLQL LSKIMDEKS----------------------------------------------G---- GG----------IYRPKGLSASATELSTISSVC-RNQES-SSNNN-YSIKEEDGVDVQA- E----------------------------------------------------------- --------------------------------------------------------SP-- ------------------------------------N--------------SWTSVGAES PGEPSA------------------------------------------------------ ------------------------------------------------DTKSPNKLSLL- ----------------------------------SLSAL-AKQEEEDFCILNNEDF---- ----------------------------------------------------ETCTDTEG -DG--------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------KEGATTSQADGQLPQ------------SGS---------- -LD-------------------------------------------------PNIDDKCE K-----------------------------CEQA-------------------------- --------------------PNVPYHILALLILLVYGCFVLPIPGYIRGMLIGMVVGFFL ALGVVWLTGP---------------------------------K---------------- ---------------------------------------------SRGHEKRHSRKLS-- ----------------KITR-----------------LDVKEPETYKGWMNEISIYDPET YHATLTQSVFVRLEGSVIRLSKPNHNISRRAGHSE--PKPDVSFVSQKIYDLRNSKVYLL PLNLAKKRVWNKKYPICIELGRQDDFMSKIDEADEDRSEDGETSSAGINQEGT------- -SE--------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------AQDQRFSL---------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------SKRDL----------------------- --------------TIFLFGRTGREKEDWFQRFLSASN---------------------- -----------------------VRVNM-KKAP--------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------SVGISTKPTASASQSSG SSRTSIDEAMAPLFKSRDSISSLTLPGSFRSKQFLEYSVYMASLLQKHQADNLTSAGSA- ---------QSPQSSPGADKK---V---------Q-SNTSAQEQLKG------------- --------------QEED-----SVAWVNATLGRLFWDFLTEPYWCEQVSKKIQMKLSKI RLPYFMNELTLTELDMGTSTPRILGASAPSVDCRGLWFDLEISYTGSFLMTLETKMILNR LGKE--EESLRLGELGKDG--PRTYCLSASDEESSSAGSSDEEDNTD------------- --------I-ANDPA-------GSESPVGGRRPSKIIRIVDKIAKSKYFQKATETEFIKK KLEEVSNTPLLLTVEVQQLRGTLAVNIPPPPTDRIWYGFRIPPHLELKARPKLGEREVTL YHVTDWIEKKLYQEFQ-------------------------------------------- ------------------------------------------------------------ --------------------------------------------------KILVMPNMDD VWLTLMHSAMDHRTAG-------------------------------------------- ----------------------------------GPLVS--------------------- --------------------------------F-PGIEEMS------------------- ---------------------------- >ENSPMEP00000001199 ----------------------------M------------------------------- ------------------------------------------------------------ -------------------------------------------TSQY------------- -----------P-----------------SHG--A---------KSTDKKP--------S --------VVAPK-----------------------LHVQRSPSKEAITIHFSALGK-ED EEEE-----------------------E-S--LF-------------------------- ------------------------------------------------------------ ------I-----------------SACPTA-----SAPL--------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------DDSNIVT--------------ALEASEEM------------------- ----------------------------------FDGASLD------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------SAASGAVIPEYSKF---------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------------SPSS------ ------------------------------------------------------------ ------TNHTNRSPTQTLSSHVPEQKA--------------------------------- ------------------------------------------------------------ ------------------------------------------------------SSAS-- ---------------------------------------------------------SSP IK-------S-------------------LSFPS-------------------T----L- G---------WGKSSSSD-IESGEGPSS----------------------ALTS------ ------S-V-----RHR-QLMKNLVKSLSSDT-SQD----------------SSSS---- -----------STS------YRLPD--SR-LNLNLLKQFAQSR----------MP-SA-- -VVAS--VND-SKTAPSSPLTSP-DNR---SF-FKVSEVEARFGDTKRRLTEAISEPLQL LSKIMDEKS----------------------------------------------G---- GG----------IYRPKGLSASATELSTISSVC-RNQES-ISNNN-YSIKEEDGVDVQA- E----------------------------------------------------------- --------------------------------------------------------SP-- ------------------------------------N--------------SWTSVGAES PGEPSA------------------------------------------------------ ------------------------------------------------DTKSPNKLSLL- ----------------------------------SLSAL-AKQEEEDFCILNNEDF---- ----------------------------------------------------ETCTDTEG -DG--------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------KEGATTTQADSQLPQ------------SGS---------- -LD-------------------------------------------------PNIDDKCE K-----------------------------CEQA-------------------------- --------------------PNVPYHILALLILLVYGCFVLPIPGYIRGMLIGMVVGFFL ALGVVWLTGP---------------------------------K---------------- ---------------------------------------------SREHEKRHSRKLS-- ----------------KITR-----------------LDVKEPETYKGWMNEISNYDPET YHATLTQSVFVRLEGSVIRLSKPNHNISRRAGHSE--PKPDVSFVSQKIYDLRNSKVYLL PLNLAKKRVWNKKYPICIELGRQDDFMSKIDEADEDRSEDGETSSAGINQEGT------- -SE--------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------AQDQRFSL---------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------SKRDL----------------------- --------------TIFLFGRTGREKEDWFQRFLSASN---------------------- -----------------------VRVNM-KKVP--------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------SVGISTKPTASSCQSSG SSRTSIDEAMAPLFKSRDSISSLTLPGSFRSKQFLEYSVYMASLLQKHQADNLTSAGSA- ---------QSPQSSPGADKK---V---------Q-SNTSAQEQLKG------------- --------------QEED-----SVAWVNATLGRLFWDFLTEPYWCEQVSKKIQMKLSKI RLPYFMNELTLTELDMGTSTPRILGASAPSVDCRGLWFDLEISYTGSFLMTLETKMILNR LGKE--EESLRLGELGKDGHRPRTYCLSASDEESSSAGSSDEEDNTD------------- --------I-ANDPA-------GSESPVGGRRPSKIIRIVDKIAKSKYFQKATETEFIKK KLEEVSNTPLLLTVEVQQLRGTLAVNIPPPPTDRIWYGFRIPPHLELKARPKLGEREVTL YHVTDWIEKKLYQEFQ-------------------------------------------- ------------------------------------------------------------ --------------------------------------------------KILVMPNMDD VWLTLMHSAMDHRTAG-------------------------------------------- ----------------------------------GPLVS--------------------- --------------------------------F-PGIEEMS------------------- ---------------------------- >ENSPFOP00000016385 ----------------------------M------------------------------- ------------------------------------------------------------ -------------------------------------------TSQY------------- -----------P-----------------SHG--A---------KSTDKKP--------S --------VVAPK-----------------------LHVQRSPSKEAITIHFSALGK-ED EEEE-----------------------E-G--LF-------------------------- ------------------------------------------------------------ ------I-----------------SACPTA-----SAPL--------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------DDSNIVT--------------ALEASEEM------------------- ----------------------------------FDGASLD------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------SAASGAVIPEYSKF---------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------------SPSS------ ------------------------------------------------------------ ------TNHTNRSPTQTLSSHVPEQKA--------------------------------- ------------------------------------------------------------ ------------------------------------------------------SSAS-- ---------------------------------------------------------SSP IK-------S-------------------LSFPS-------------------T----L- G---------WGKSSSSD-IESGEGPSS----------------------ALTS------ ------S-V-----RHR-QLMKNLVKSLSSDT-SQD----------------SSSS---- -----------STS------YRLPD--SR-LNLNLLKQFAQSR----------MP-SV-- -AVAS--VND-SKTAPSSPLTSP-DNR---SF-FKVSDVEARFGDTKRRLTEAISEPLQL LSKIMDEKS----------------------------------------------G---- GG----------IYRPKGLSASATELSTISSVC-RNQES-ISNNN-YSIKEEDGVDVQA- E----------------------------------------------------------- --------------------------------------------------------SP-- ------------------------------------N--------------SWTSVGAES PGEPSA------------------------------------------------------ ------------------------------------------------DTKSPNKLSLL- ----------------------------------SLSAL-AKQEEEDFCILNNEDF---- ----------------------------------------------------ETCTDTEG -DG--------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------KEGATTTQADSQLPQ------------SGS---------- -LD-------------------------------------------------PNIDDKCE K-----------------------------CEQA-------------------------- --------------------PNVPYHILALLILLVYGCFVLPIPGYIRGMLIGMVVGFFL ALGVVWLTGP---------------------------------K---------------- ---------------------------------------------SREHEKRHSRKLS-- ----------------KITR-----------------LDVKEPETYKGWMNEISIYDPET YHATLTQSVFVRLEGSVIRLSKPNHNISRRAGHSE--PKPDVSFVSQKIYDLRNSKVYLL PLNLAKKRVWNKKYPICIELGRQDDFMSKIDEADEDRSEDGETSSAGINQEGT------- -SE--------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------AQDQRFSL---------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------SKRDL----------------------- --------------TIFLFGRTGREKEDWFQRFLSASN---------------------- -----------------------VRVNM-KKVP--------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------SVGISTKPTASSCQSSG SSRTSIDEAMAPLFKSRDSISSLTLPGSFRSKQFLEYSVYMASLLQKHQADNLTSAGSA- ---------QSPQSSPGADKK---V---------Q-SNTSAQEQLKG------------- --------------QEED-----SVAWVNATLGRLFWDFLTEPYWCEQVSKKIQMKLSKI RLPYFMNELTLTELDMGTSTPRILGASAPSVDCRGLWFDLEISYTGSFLMTLETKMILNR LGKE--EESLRLGELGKDGHRPRTYCLSASDEESSSAGSSDEEDNTD------------- --------I-ANDPA-------GSESPVGGRRPSKIIRIVDKIAKSKYFQKATETEFIKK KLEEVSNTPLLLTVEVQQLRGTLAVNIPPPPTDRIWYGFRIPPHLELKARPKLGEREVTL YHVTDWIEKKLYQEFQ-------------------------------------------- ------------------------------------------------------------ --------------------------------------------------KILVMPNMDD VWLTLMHSAMDHRTAG-------------------------------------------- ----------------------------------GPLVS--------------------- --------------------------------F-PGIEEMS------------------- ---------------------------- >ENSPREP00000003343 ----------------------------M------------------------------- ------------------------------------------------------------ -------------------------------------------TSQY------------- -----------P-----------------SHG--A---------KSTDKKP--------S --------VVAPK-----------------------LHVQRSPSKEAITIHFSALGK-EE EEEE-----------------------EDD--LF-------------------------- ------------------------------------------------------------ ------I-----------------SACPTA-----SAPL--------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------DDSNIVT--------------ALEASEEM------------------- ----------------------------------FDGASLD------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------SAASGAVIPEYSKL---------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------------SPSS------ ------------------------------------------------------------ ------SNHTNRSPTQTLSSHVPEQRA--------------------------------- ------------------------------------------------------------ ------------------------------------------------------SSAN-- ---------------------------------------------------------SSP IK-------S-------------------LSFPS-------------------T----L- G---------WAKSPSSD-IESAEGPSS----------------------ALTS------ ------S-V-----RHR-HLMKNLVKSLSSDT-SQD----------------SPSS---- -----------STS------YRLPD--SR-LNLNLLKQFAQSR----------MP-SA-- -AVAS--VND-SKTAPSSLLTSP-DNR---SF-FKVSEVEARFEDTKRRLTEAISEPLHL LSKIMDEKS----------------------------------------------G---- GG----------LYRPKGLSASATELSTISSVC-RNQESNSSNNN-HSIKEEDGVDVPA- E----------------------------------------------------------- --------------------------------------------------------SP-- ------------------------------------N--------------SWTSVGAES PGEPSD------------------------------------------------------ ------------------------------------------------DTKNPNKLSLL- ----------------------------------SLSAL-AKQEEEDFCILNNEDF---- ----------------------------------------------------ETCTDTEG -EG--------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------KKGATTTQADSQLPQ------------SAS---------- -LD-------------------------------------------------PSIDDKRE K-----------------------------CEQA-------------------------- --------------------PYVPYHILALLILLVYGSFVLPIPGYIRGMLIGMVVGFFL ALGVVWLTGP---------------------------------K---------------- ---------------------------------------------SHGHEKRHSRELS-- ----------------KITR-----------------LDVKEPETYKGWMNEISNYDPET YHATLTQSVFVRLEGSVIRLSKPNHNISRRAGHSE--PKPDVSFVSQKIYDLRNSKVYLL PLNLAKKRVWNKKYPICIELGRQDDFMSKIDEANEDRLEDDETSNAGMNQEGT------- -SE--------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------AQDQQFSL---------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------SQRDL----------------------- --------------TIFLFGRTGREKEDWFQRFLSASNFRVKKVPSGGISTKATASACQS P-----------RSRRSSLEEVI------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------APLFKSRGSISSLTLPGRPRSKPFLEYSVYMASLLQNHQADDLTSAGSA- ---------QSPQSSPGADKK---V---------Q-SNTSAQEQPKG------------- --------------QEED-----SVAWVNAALGRLFWDFLTEPYWCEQVSKKIQMKLSKI RLPYFMNELTLTELDMGTSTPRILGASAPSVDCRGLWFDLEISYTGSFLMTLETKMILNR LGKE--EESLHSGELGKDGHRPRTYCLSASDEESSSAGSSDEEDYTD------------- --------I-ANDPA-------GSESPVGGRRPNKIIRFVDKIAKSKYFQKATETEFIKK KLEEVSNTPLLLTVEVQQLRGTLAVNIPPPPTDRIWYGFRIPPHLELKARPKLGEREVTL YHVTDWIEKKLYQEFQ-------------------------------------------- ------------------------------------------------------------ --------------------------------------------------KILVMPNMDD VWLTLMHSAMDHRTAG-------------------------------------------- ----------------------------------GPLVS--------------------- --------------------------------F-PGIEKMS------------------- ---------------------------- >ENSGAFP00000011563 ----------------------------M------------------------------- ------------------------------------------------------------ -------------------------------------------TSQD------------- -----------P-----------------SHG--A---------KSTDKKP--------S --------VVAPK-----------------------LHVQRSPSKEAITIHFSALGK-EE EEEE-----------------------E-G--LF-------------------------- ------------------------------------------------------------ ------I-----------------AARPTA-----SAPL--------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------DDSNIVT--------------AVEASEEM------------------- ----------------------------------FDGASLD------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------SAAGVAVIPESSGF---------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------------SPSS------ ------------------------------------------------------------ ------SNQTNRFPTQILSSHVPEQKA--------------------------------- ------------------------------------------------------------ ------------------------------------------------------SSAN-- ---------------------------------------------------------SSP IK-------S-------------------LSFPS-------------------T----L- G---------WAKSPSSD-IESREGASS----------------------APTS------ ------S-V-----RHR-QLMKSLVKSLSSDT-SQD----------------SSSS---- -----------STS------YRLPD--SR-LNLSLLKQFAQSR----------MP-SA-- -AVAS--VND-SKTAPSSPLVSP-DNR---SF-FKVSEVEARFEDTKRRLTEAISEPLQL LSKIMDEKS----------------------------------------------G---- GG----------IYRPKGLSASATELSTISSVC-RNQES--NNNN-YCIKEEDGVDVQA- E----------------------------------------------------------- --------------------------------------------------------SP-- ------------------------------------N--------------SWTSVGVES PGEPSA------------------------------------------------------ ------------------------------------------------DSKSPNKLSLL- ----------------------------------NLSAL-AKQEEEDFCILNNEDF---- ----------------------------------------------------ETCTDTEG -ES--------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------NEGTTTTQADSQLSQ------------SGS---------- -LN-------------------------------------------------PSNDDECE E-----------------------------CEQA-------------------------- --------------------PYVPYYTLALLTLVVYGCFVLPFPGYIRGILFGIGVGFFL AIGVVWLTGP---------------------------------K---------------- ---------------------------------------------SRGLEKRHSRKLS-- ----------------KIIR-----------------LDVKEPETYKGWMNEISNYDPET YHATLTQSVFVRLEGSVIRLSKPNRNISRRAGHSE--PKPDVSFVSQKIYDLRNSKIFLT PLNLAKKRVWNKKYPICIELGRQADFMSKIDEPDEGRLEDGETLSAGINQEGT------- -SE--------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------AQDRRSSL---------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------SKRDL----------------------- --------------TIFLFGRTGREKEDWFQRFLSASN---------------------- -----------------------VRVNM-KKVP--------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------SVGISAKATISAGHSPR SSRTVSDEAMAPLFKSRDSISSLTLSGSSRSKLLLEYSVYMASLLQNHRADNLTSAGFA- ---------ESPQSSPATDKK---V---------Q-SNASAQEQPKG------------- --------------QEED-----SVAWVNAALGRLFWDFLTEPYWCEQVSKKIQMKLSKI RLPYFMNELTLTELDMGTTTPRILGASAPSVDCRGLWFDLEISYNGSFLMTLETKMILNR LGKE--EESLRLGEFGKDGHRPRTYCLSASDEESSSAGSSDEEDNAD------------- --------I-SNDSA-------GSESLVGGRRSSKIMRFVDKIAKSKYFQKATETEFIKK KLEEVSNTPLLLTVEVQQLRGTLAVNIPPPPTDRIWYGFRIPPHLELKARPKLGEREVTL FHVTDWIEKKLYQEFQ-------------------------------------------- ------------------------------------------------------------ --------------------------------------------------KILVMPNMDD VWLTVMHSAMDHRTAG-------------------------------------------- ----------------------------------GPLVS--------------------- --------------------------------F-PGMEELS------------------- ---------------------------- >ENSXMAP00000017936 ----------------------------M------------------------------- ------------------------------------------------------------ -------------------------------------------TSQY------------- -----------P-----------------SHG--A---------KSTDKKP--------S --------VAAPK-----------------------LHVQRSPSKEAITIHFSALGK-EE EEEE-----------------------D-G--LF-------------------------- ------------------------------------------------------------ ------I-----------------TACPTA-----SAPL--------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------DDSNIVT--------------ALEASEEM------------------- ----------------------------------FDGASLD------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------SAAGVAVMPDSSRF---------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------------SPSS------ ------------------------------------------------------------ ------SNHSNRSPTQTLSSHVLEQKA--------------------------------- ------------------------------------------------------------ ------------------------------------------------------SSAN-- ---------------------------------------------------------SSP IK-------S-------------------LSFPS-------------------T----L- T---------WAKSSSSD-TESREGPTS----------------------APTS------ ------S-V-----RHR-QLMKNLVKSLSSDT-SQD----------------SSSS---- -----------STS------YRLPD--SR-LNLNLLKQFAQSR----------MP-SA-- -ALAS--VND-SKTAPPSPLVSP-DNR---SF-FKVSEVEARFEDTKRRLTEAISEPLQL LSKIMDEKS----------------------------------------------G---- GG----------IYRPKGLSASATELSTISSVC-RNQES---NNN-YCIKEEDGVDVQA- E----------------------------------------------------------- --------------------------------------------------------SP-- ------------------------------------N--------------SWTSVGAES LDEPSA------------------------------------------------------ ------------------------------------------------DTKSPNKLSLL- ----------------------------------SLSAL-AKQEEEDFCILNSEDF---- ----------------------------------------------------ETCTDTEG -EG--------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------NEGTATTQAGSQLPQ------------SGS---------- -LD-------------------------------------------------PSNDDECE V-----------------------------CEQA-------------------------- --------------------PNVPYYTLAFLTLLVYGCFVLPIPGYIRGMLFGIGVGFFL AIGVVWLTGP---------------------------------K---------------- ---------------------------------------------SRGLEKRHSRKLS-- ----------------KIIR-----------------LDVKEPETYKGWMNEILNYDPET YHATLTQSVFVRLEGSIIRLSKPNHNISRRAGHSE--PKPDVSFVSQKIYDLRNSKVYLT PLNLAKKRVWNKKYPICIELGRQDDFMSKIDEPDEGRLEDGETLSAGINQEGT------- -SE--------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------AQDRRSSL---------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------FKREL----------------------- --------------TIFLFGRTGREKEDWFQRFLSASN---------------------- -----------------------VRVNM-KKRP--------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------SVGISTKATISDCHSPR SSRTSSDEAMAPLFKSRDTTSSLTLSGSSRSKLFLEYSVYMASLLQNHQADNLTSAGFA- ---------QSPQSSPGVDKK---V---------Q-SNTSAPEQPKG------------- --------------QEED-----SVAWVNAALGRLFWDFLTEPYWCEQVSKKIQMKLSKI RLPYFMNELTLTELDMGTSTPRILGASAPSVDSRGLWFDLEISYNGSFLMTLETKMILNR LGKE--EESLRLGEFGKDGHRPRTYCLSASDEESSSAGSSDEEDNAD------------- --------I-SNDSV-------GSESLVGGRRSSKIMRFVDKIAKSKYFQKATETEFIKK KLEEVSNTPLLLTVEVQQLRGTLAVNIPPPPTDRIWYGFRIPPHLELKARPKLGEREVTL FHVTDWIEKKLYQEFQ-------------------------------------------- ------------------------------------------------------------ --------------------------------------------------KILVMPNMDD VWLTLMHSAMDHRTAG-------------------------------------------- ----------------------------------GPLVS--------------------- --------------------------------F-PGIEKLS------------------- ---------------------------- >ENSCVAP00000023479 ----------------------------M------------------------------- ------------------------------------------------------------ -------------------------------------------TSQY------------- -----------P-----------------SHG--E---------RSPDKKP--------A --------TVAPK-----------------------LHVQQSPSKEAITIHFSAFGK-EE DEEE-----------------------E-G--LF-------------------------- ------------------------------------------------------------ ------I-----------------TASSTA-----PAPL--------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------DGSNIVT--------------ALEASEEM------------------- ----------------------------------FEGEPLD------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------SASP-------TRF---------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------------SPSS------ ------------------------------------------------------------ ------SNHTNRSP-QTLSSTVPEHKA--------------------------------- ------------------------------------------------------------ ------------------------------------------------------STAN-- ---------------------------------------------------------SSP IK-------S-------------------LSFPS-------------------T----L- GLVKALPPDD--------------GASS----------------------APT------- --------I-----RHR-QLMKSLVKSLSSDT-SQD----------------SSSS---- -----------SSS------YRLPE--SR-LNLQVLKQFAQSR----------MQ-SA-- -SMAS--ISD-SKTAPSSPLTSQ-ENR---SF-FKVSEVEARFEDTKRRLTEAISEPLQL LSKIIDEKS----------------------------------------------A---- SS----------IYRPKGLSSSATELSTLTSLN-GNQES---NNN-YCIKEEGG-EGEA- E----------------------------------------------------------- --------------------------------------------------------SP-- ------------------------------------N--------------SWTAVGAES PAGPCS------------------------------------------------------ ------------------------------------------------NTKSPNNLSLL- ----------------------------------SMSAL-AKLDEEDFCILNNEDF---- ----------------------------------------------------ESCTDTEG -EGIEGSNN-----------------------------------------------TLPL S-------------SCSDPSCDD------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -------------EYEGFES---------------------------------------- ------------------------------------------------------------ ---------------------------------A-------------------------- --------------------PDVPHYTLAVLTFLLYTCFVLPLPSYVGGVLLGIGLGFFL AIGIVWLTGP---------------------------------K---------------- -------------R-SG-GDV-----------KYS---------RNH-------RELW-- ----------------NVTK-----------------MDVKEPESYKGWMNEISNYDPET YHATLTHSVFVRLEGSIIRLSKPNHNIARRASHNE--PKSDMSFVSQKIYDLSNSKVYLV PQNLARKRVWNKKYPICIELGRQDDFMSK------------------------------- -AEDE------------------------------------------------------- ----------R-------------------------------SEASES------------ -----------------------------------------------------STS-ELN GERTSAAQDRRSSV---------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------TRRDR----------------------- --------------TIFLFGRTGREKEEWFQRFLSASN---------------------- -----------------------VRADL-KQVPCFGTSKK-------------------- ------------------------------------------------------------ -----------------------ASH----------------SRS------------SSR SSLDEVLAPPL--KSRDS----TTSLMTAG-S---------------------------- ---AKNKLPLDYSVYMASVM---------------------PK---------------NQ AV-------------------G-----------------LPSSS---------------- ---------------------------------------------------------SS- ---------QSLQSTPGADKK---L---------Q-NSTTAQAQPRG------------- --------------EEEE-----SVAWVNAALGRLFWDFLTEPYWVEEVSKKIQMKLSKI RLPYFMNELTLTELDMGTSTPRIHQASAPYVDCRGLWFDLEVSYNGSFLMTLETKMILNR LGKD--GESLRLGEFGKEGYRPRTYCLAASDEESSSAGSSDEEDSSD------------- --------L-SNDST-------GADSLVGGHKPSKIMRFVDKIAKSKYFQKATETEFIKK KMEEVSNTPLLLTVEVQQLRGTLAVNIPPPPTDRIWYGFRTPPHLELKARPKLGEREVTL AHVTDWIEKKLYQEFQ-------------------------------------------- ------------------------------------------------------------ --------------------------------------------------KILVMPNMDD VWLTIMHSAMDPRTAG-------------------------------------------- ----------------------------------GPLVS--------------------- --------------------------------P-PGNTEPS------------------- ---------------------------- >ENSOMEP00000020346 ----------------------------M------------------------------- ------------------------------------------------------------ -------------------------------------------TSQH------------- -----------P-----------------NHGDSS---------NS-NKQS--------P --------AMGPK-----------------------LQVQGSLSKETITIHFSALGK-EE EDEE-----------------------E-E--LY-------------------------- ------------------------------------------------------------ ------C-----------------TTVTGN-----SSVL--------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------NDSNVVT--------------AIEASEEM------------------- ----------------------------------FEGAPLN------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------PSTSSGVTPATSRHSPSSRHRSPPSQTRSTYSFDKT ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------------------SN-- ---------------------------------------------------------SSP TK-------S-------------------LSYPS-------------------IEKPVL- S---------LLKNLSSD-AEPRDGASS----------------------ASST------ ------A-L-----RHR-QLMKNLVKSLSSDT-SQD----------------SSSS---- -----------STS------YRLPE--PR-LNLQLFKQFAQSR----------LP-AA-- -AASL--ASD-SKTAPSSPLTSP-ENR---SF-FKVSEVEARIEDTRRRLSEAISEPLQL FSKIMDEKS---S----------------------------------------------- SS----------LYRPKVLSASATELT---TIN-GQLEN---NNN-YSIKEEDG----S- E----------------------------------------------------------- --------------------------------------------------------SP-- ------------------------------------N--------------SWTSV---T PDDSSA------------------------------------------------------ ------------------------------------------------NTKSPNKS--F- ---------SA------------------ALDKCSMSAL-AKQEDEDFCILTNEDF---- ----------------------------------------------------D------- -----------FSPLAEAADRIDKTRTGKPVAVHGREDGA-------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------------------DTYG G-----------------------------TEPA-------------------------- --------------------PDIPHYTLTALALLLYGCFVLPLPTYVGGMLLGIALGFFL ALGVVWLTGP---------------------------------KRFEGHQRHSSQ----- -------------P-S-------------------------------------------- ----------------NATK-----------------FEIKEPEIYKGWMNEIFNYDPET YHATLTHSVFVRLEGSIIRLSKPNHNIARRAAHND--SKPDVTFVSQKIYDLANSKVYLV PPGLARKRVWNKKYPICIELSRQDDFMSK------------------------------- -AEGD------------------------------------------------------- ----------R-------------------------------SEPGDAVGTSEGGE---- -------------------------------------------ASRG------------- ------------------------------------------------------------ ------------------------------------------------------------ -------ASSP------------------------------------------------- --------------------------------SSRDL----------------------- --------------TLFLFGRTGREKEEWFQRFLSASN---------------------- -----------------------PKV-T-RKAS--------------------------- ------------------------------------------------------RVAS-- ------------------A---WSSH----------------SRS------------SSR SSLDEMLTAQP--RLKDS----AASSTTS--S---------------------------- ---AKSKPPLDYNHYMGCLL---------------------PK---------------QP AV-------------------GA----SAS-----CPV-L-------------------- ------------------------------------------------------------ ---------QSLQSSPGAEKK---P---------H-STTAAQLQPKGD------------ ----------ED--EEED-----TVAWVNAAMGRIFWDFLTEPHWAEVVSKKIQMKLSKI RLPYFMNELTLTELDMGSATPRIHAASAPYCDYRGLWFDLEVSYTGSFQMTLETKMILNR LGKE--GENLRLGEFGKDG--PRTDCLAYSDEESSSAGSSDEEDSSE------------- --------L-SNDSA-------GAEGFVGGHKASKILRFVDKITKSKYFQKATETEFIKK KMDEVSNTPLLLTVEVQHLQGTLAVNIPPPPTDRIWYGFKTPPRLDLKARPKLGEREVTL AHVTDWIEKKLYQEFQ-------------------------------------------- ------------------------------------------------------------ --------------------------------------------------KILVMPNMDD VWLTIMHSAMDPRTAG-------------------------------------------- ----------------------------------GPLVS--------------------- --------------------------------P-SVDPALS------------------- ---------------------------- >ENSORLP00020013362 ----------------------------M------------------------------- ------------------------------------------------------------ -------------------------------------------TSQH------------- -----------P-----------------NYGVSS---------NS-NKQP--------P --------AMGPK-----------------------LQVQGSLSKESITIHFSALGKEEE EEEE-----------------------E-E--LN-------------------------- ------------------------------------------------------------ ------C-----------------TTVTSN-----SSVL--------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------NDSNVVT--------------AIEASEEM------------------- ----------------------------------FEGASLH------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------PSPSSGVTPASSRLSPSSRHRSPPSQTRSTYSFDKT ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------------------SSN-- ---------------------------------------------------------SSP TK-------S-------------------LSYPS-------------------IEKPVL- S---------LLKNLSSD-TDPRDG-------------------------ASST------ ------S-L-----RHR-QLMKNLVKSLSSDT-SQE----------------SSSS---- -----------STS------YRLPE--SR-LNLQLFKQFAQSR----------LPAAA-- -AASL--ASD-SKTAPSSPLTSP-DSR---SF-FKVSEVEARIEDTKRRLSEAISEPLQL LSKMMDERS---SN-LV--------------------------------------G---- SS----------LYRPKVLSSSATELT---TIN-SQLEN---NNN-YSIKEEDG----S- E----------------------------------------------------------- --------------------------------------------------------SP-- ------------------------------------S--------------SWTSV---T PDDSSA------------------------------------------------------ ------------------------------------------------NTKSPNKS--F- ---------SV------------------ALDKCTMSAL-AKQEDEDFCILSNEDF---- ----------------------------------------------------E------- -----------LSPIAEALDRTDKTRTGKQVPVNGREDSV-------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------------------DRCE G-----------------------------TEPA-------------------------- --------------------PDIPHYTLTGFTLLLYGCFVLPLPSYIGGMLLGIGLGFYF ALGVVWLTGP---------------------------------KRSEGRQGHSSQQGR-- -------------P-S-------------------------------------------- ----------------NATK-----------------LEIKEPEIYKGWMNEISNYDPET YHATLTHSVYVRVEGSTIRLSKPNHNIARRAAHND--SKPDVTFVSQKIYDLASSKVYLV PPGLARKRVWNKKYPICIELSRQDDFMSK------------------------------- -AEGD------------------------------------------------------- ----------R-------------------------------SEPSDGVRTLETGE---- -------------------------------------------ANHG------------- ------------------------------------------------------------ ------------------------------------------------------------ -------ASSP------------------------------------------------- --------------------------------SSKDL----------------------- --------------TLFLFGRTGRDKEEWFQRFLSASN---------------------- -----------------------PKVDA-RKAS--------------------------- ------------------------------------------------------RVGS-- ------------------A---WSSH----------------SRN------------GSR SSLDELLAAQP--RLKDS----AGSSTTS--S---------------------------- ---AKSKPPLDYNVYMGCLL---------------------PK---------------QP AA-------------------GA----SAS-----CPA-L-------------------- ------------------------------------------------------------ ---------QSLQSSPGAEKK---P---------H-STTAAQVQPKGE------------ ----------EE-DEEEE-----TVAWVNAAMGRVFWDFLTEPYWSKVVSKKIQMKLSKI RLPYFMNELTLTELDMGSATPRIHAASAPYCDYRGLWFDLEVSYSGSFLMTLETKMILNR LGKE--GENLRLGEFGKDG--PRTYCLAYSDEESSSAGSSDEEDSSE------------- --------L-SNDSA-------GAEGFVGGHKASKILRFVDKITKSKYFQKATETEFIKK KMEEVSNTPLLLTVEVQHLQGTLAVNIPPPPTDRIWYGFKTPPRLELKARPKLGEREVTL AHVTDWIEKKLYQEFQ-------------------------------------------- ------------------------------------------------------------ --------------------------------------------------KILVMPNMDD VWLTIMHSAMDPRTAG-------------------------------------------- ----------------------------------GPLVG--------------------- --------------------------------P-STDPPLS------------------- ---------------------------- >ENSORLP00015012972 ----------------------------M------------------------------- ------------------------------------------------------------ -------------------------------------------TSQH------------- -----------P-----------------NYGVSS---------NS-NKQP--------P --------AMGPK-----------------------LQVQGSLSKESITIHFSALGK-EE EEEE-----------------------E-E--LN-------------------------- ------------------------------------------------------------ ------C-----------------TTVTSN-----SSVL--------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------NDSNVVT--------------AIEASEEM------------------- ----------------------------------FEGASLY------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------PSPSSGVTPASSRLSPSSRHRSPPSQTRSTYSFDKT ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------------------SSN-- ---------------------------------------------------------SSP TK-------S-------------------LSYPS-------------------IEKPVL- S---------LLKNLSSD-TDPRDG-------------------------ASST------ ------S-L-----RHR-QLMKNLVKSLSSDT-SQE----------------SSSS---- -----------STS------YRLPE--SR-LNLQLFKQFAQSR----------LPAAA-- -AASL--ASD-SKTAPSSPLTSP-DSR---SF-FKVSEVEARIEDTKRRLSEAISEPLQL FSKMMDERS---SN-LV--------------------------------------G---- SS----------LYRPKVLSSSATELT---TIN-SQLEN---NNN-YSIKEEDG----S- E----------------------------------------------------------- --------------------------------------------------------SP-- ------------------------------------S--------------SWTSV---I PDDSSA------------------------------------------------------ ------------------------------------------------NTKSPNKS--F- ---------SV------------------ALDKCTMSAL-AKQEDEDFCILSNEDF---- ----------------------------------------------------E------- -----------LSPIAEALDRTDKTRTGKQVLVNGREDSV-------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------------------DRCE G-----------------------------TEPA-------------------------- --------------------PDIPHYTLTGFTLLLYGCFVLPLPSYIGGMLLGIGLGFYF ALGVVWLTGP---------------------------------KRSEGRQGHSSQQGR-- -------------P-S-------------------------------------------- ----------------NATK-----------------LEIKEPEIYKGWMNEIFNYDPET YHATLTHSVYVRLEGSTIRLSKPNHNIARRAAHND--SKPDVTFVSQKIYDLANSKVYLV PPGLARKRVWNKKYPICIELSRQDDFISK------------------------------- -AEGD------------------------------------------------------- ----------R-------------------------------SEPSDGVSTSETGE---- -------------------------------------------VNHG------------- ------------------------------------------------------------ ------------------------------------------------------------ -------ASSP------------------------------------------------- --------------------------------SSKDL----------------------- --------------TLFLFGRTGRDKEEWFQRFLSASN---------------------- -----------------------PKVDA-RKAS--------------------------- ------------------------------------------------------RVGS-- ------------------A---WSSH----------------SRN------------GSR SSLDELLAAQP--RLKDS----AGSSTTS--S---------------------------- ---AKSKPPLDYNVYMGCLL---------------------PK---------------QP AV-------------------GA----SAS-----CPA-L-------------------- ------------------------------------------------------------ ---------QSLQSSPGAEKK---P---------H-STTAAQVQPKGE------------ ----------EE--EEEE-----TVAWVNAAMGRVFWDFLTEPYWSKVVSKKIQMKLSKI RLPYFMNELTLTELDMGSATPRIHAASAPYCDYRGLWFDLEVSYSGSFLMTLETKMILNR LGKE--GENLRLGEFGKDG--PRTYCLAYSDEESSSAGSSDEEDSSE------------- --------L-SNDSA-------GAEGFVGGHKASKILRFVDKITKSKYFQKATETEFIKK KMEEVSNTPLLLTVEVQHLQGTLAVNIPPPPTDRIWYGFKTPPRLELKARPKLGEREVTL AHVTDWIEKKLYQEFQ-------------------------------------------- ------------------------------------------------------------ --------------------------------------------------KILVMPNMDD VWLTIMHSAMDPRTAG-------------------------------------------- ----------------------------------GPLVG--------------------- --------------------------------P-STDPPLS------------------- ---------------------------- >ENSORLP00000028594 ----------------------------M------------------------------- ------------------------------------------------------------ -------------------------------------------TSQH------------- -----------P-----------------NYGVSS---------NS-NKQP--------P --------AMGPK-----------------------LQVQGSLSKESITIHFSALGK-EE EEEE-----------------------E-E--LN-------------------------- ------------------------------------------------------------ ------C-----------------TTVTSN-----SSVL--------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------NDSNVVT--------------AIEASEEM------------------- ----------------------------------FEGGSLQ------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------PSPSSGVTPASSRLSPSSKHRSPPSQTRSTYSFDKT ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------------------SSN-- ---------------------------------------------------------SSP TK-------S-------------------LSYPS-------------------IEKPVL- S---------LLKNPSSD-TDPRDG-------------------------ASST------ ------S-L-----RHR-QLMKNLVKSLSSDT-SQE----------------SSSS---- -----------SSS------YRLPE--SR-LNLQLFKQFAQSR----------LPAAA-- -AASL--ASD-SKTAPSSPLTSP-DSR---SF-FKVSEVEARIEDTKRRLSEAISEPLQL FSKMMDERS---SN-LV--------------------------------------G---- SS----------LYRPKVLSSSATELT---TIN-SQLEN---NNN-YSIKEEDG----S- E----------------------------------------------------------- --------------------------------------------------------SP-- ------------------------------------S--------------SWTSV---T PDDSSA------------------------------------------------------ ------------------------------------------------NTKSPNKS--F- ---------SV------------------ALDKCTMSAL-AKQEDEDFCILSNEDF---- ----------------------------------------------------E------- -----------LSPIAEALDRTDKTRTGKQVPVNGREDSV-------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------------------DRCE G-----------------------------TEPA-------------------------- --------------------PDIPHYTLTGFTLLLYGCFVLPLPSYIGGMLLGIGLGFYF ALGVVWLTGP---------------------------------KRSEGRQGHSSQQGR-- -------------P-S-------------------------------------------- ----------------NATK-----------------LEIKEPEIYKGWMNEIFNYDPET YHATLTHSVYVRVEGSTIRLSKPNHNIARRAAHND--SKPDVTFVSQKIYDLANSKVYLV PPGLARKRVWNKKYPICIELSRQDDFISK------------------------------- -AEGD------------------------------------------------------- ----------R-------------------------------SEPSDGVGTSETGE---- -------------------------------------------ANHG------------- ------------------------------------------------------------ ------------------------------------------------------------ -------ASSP------------------------------------------------- --------------------------------SSKDL----------------------- --------------TLFLFGRTGRDKEEWFQRFLSASN---------------------- -----------------------PKVDT-RKAS--------------------------- ------------------------------------------------------RVGN-- ------------------A---WSSH----------------SRN------------GSR SSLDELLAAQP--RLKDS----AGSSTTS--S---------------------------- ---AKSKPPLDYNVYMGCLL---------------------PK---------------QP AV-------------------GA----SAS-----CPA-L-------------------- ------------------------------------------------------------ ---------QSLQSSPGAEKK---P---------H-STTAAQVQPKGE------------ ----------DE--EEEE-----TVAWVNAAMGRVFWDFLTEPYWSKVVSKKIQMKLSKI RLPYFMNELTLTELDMGSATPRIHAASAPYCDYRGLWFDLEVSYSGSFLMTLETKMILNR LGKE--GENLRLGEFGKDG--PRTYCLAYSDEESSSAGSSDEEDSSE------------- --------L-SNDSA-------GAEGFVGGHKASKILRFVDKITKSKYFQKATETEFIKK KMEEVSNTPLLLTVEVQHLQGTLAVNIPPPPTDRIWYGFKTPPRLELKARPKLGEREVTL AHVTDWIEKKLYQEFQ-------------------------------------------- ------------------------------------------------------------ --------------------------------------------------KILVMPNMDD VWLTIMHSAMDPRTAG-------------------------------------------- ----------------------------------GPLVG--------------------- --------------------------------P-STDPPLS------------------- ---------------------------- >ENSHCOP00000024193 ----------------------------M------------------------------- ------------------------------------------------------------ -------------------------------------------TSQH------------- -----------P-----------------SHAEST---------YSTDKQP--------P --------ALASK-----------------------LHVRRSDSNETLTIHFSALGK-EE EEEE-----------------------E-E--LY-------------------------- ------------------------------------------------------------ ------T-----------------TSVSST-----STTQ--------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------DEFNIVT--------------GVEASEEM------------------- ----------------------------------FE------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------AQQSDGSGDVAPTAHSTKR- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------SPLSTSHTTSLP------------------ ------------------------------------------------------------ --------------------HLAEQKG--------------------------------- ------------------------------------------------------------ ------------------------------------------------------TSSN-- ---------------------------------------------------------SSP TK-------S-------------------LSFPS-------------------ADKSFL- T---------LMKSLSSD-IESKDGVSS----------------------MTAP------ ------A-T-----RHR-HIMKSLVKSLSSDT-SQD----------------SS------ -------------------PNRLSE--SR-LNLQLFKQFTQSR----------MH-NT-- -TTSA--ASD-SKTAPCSPLISP-DNR---SF-FKVSEVEARIEDTKRRFSEAIYEPLQL LSKIMDEKS----------------------------------------------S---- SS----------LSRPKALSASASELYNLNSVT-GHFES---NNN-DCIKEEEGSELER- E----------------------------------------------------------- --------------------------------------------------------SP-- ------------------------------------E--------------SGTSAPADS --------------------------HV-------------------------------- -------------------------APFGI--------------------KSPNKSSSF- ---------PI------------------SLDKCSMSAL-AKQEDEDFCILYSEDF---- ----------------------------------------------------ESST---- ------TDND-------------------------------------------------- ------VG---------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------TGTDRQPQLPLSGT---------- -TE-------------------------------------------------PCIENETE D-----------------------------AEPS-------------------------- --------------------PSVPHKTLFILTILVYGFFILPLPDHVRGVLIGVALGFFV AIGVVWLAGP---------------------------------K---------------- -------------P-DR-P-F-----------TYS---------KNH-------GKLW-- ----------------NLPQ-----------------LDIKEPEIFKGWMNEITNYDPET YHATLTHSVFVRLEGSVIRLSKPNHNIARRAIHNE--PKPDVTYISQKIYDLTNSKVHLL PQSLARKRIWNKKYPICIELGKQDDFISK------------------------------- -VEGD------------------------------------------------------- ----------T-------------------------------SE---------------- ------------------------------------------------------------ ----------------------------------------------NRKEGTGGTQEPTR P----------------------------------------------------------- ---------MS------------------------------------------------- --------------------------------SSRDL----------------------- --------------TLFLFGRTGREKEEWFQRFMSASM---------------------- -----------------------LKIDL-KK--------------------PVFFQL--- -----LP--------------------T-------------------------------- ------------------A---LSSH----------------SRS------------SSR SSLDEALASQP--RTKDS----P----TAG-S---------------------------- ---VKTQ-LLDYTVYMASLL---------------------TK---------------PI AL-------------------KS----PAT-----SSE-L-------------------- ------------------------------------------------------------ ---------HCPQSSPGAEKK--------------------------------------- --------------EGED-----AVAWVNAAVGRLFWDFLREPYWAEVVSKKIQMKLSKI RLPYFMNELALKELDMGVATPKILGASNPSIDYKGLWFDLDVSYSGSFLMTLETKMNLIR LGKE--GESLRFGEDG-----PRTYCLADSDEESSSAGSSDEEDATDGCVCVCVCVCVCV RVCVRVRG--------------------------KIMRFVDKITRSKYFQKATETEFIKK KMEEVSNTPLLLTVELQKLQGTLAVNIPPPPTDRIWYGFRKPPHLELKARPKLGEREVTL AHVTDWIEKKLEQELQ-------------------------------------------- ------------------------------------------------------------ --------------------------------------------------KIFVMPNMDD VWLTIMHSAMDQRTAA-------------------------------------------- ----------------------------------GTLAS--------------------- --------------------------------S-AADQQPS-----------HPDSDGTS ---------------------------- >ENSPMGP00000012467 ----------------------------M------------------------------- ------------------------------------------------------------ -------------------------------------------TSQP------------- -----------P-----------------SHAESA---------QSTTRPL--------L --------TVAPK-----------------------FQLPRPPSRETVTIHFSAQRK-DE EEED-----------------------G-E--IT-------------------------- ------------------------------------------------------------ ------M-----------------TNTSTT-----SAPQ--------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------DDSSIVT--------------GLEASEEM------------------- ----------------------------------FE------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -DAFQEFSTGSHVSPETTGCSAESKLTTPAASHTEKNT---------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------------------TSP SK-------S-------------------LSFPS-------------------SDKPFL- S---------LVKSLSSD-IESKDGSAS-----------------------SSS------ ------S-I-----RHR-HL-KNLVKSFSSDTSSQD----------------QPSS---- -----------STS-------RLPE--SR-LNLQLFRQFTQSR----------LP-SA-- -SLST--VGD-SKTAPTSPMTSP-ENR---SF-FKVAEVEARIEDTKRRFSEAIAEPLQL LTKMIDEKS---GS-KG--------------------------------------T---- GG----------IYRPKVISTSASELSNLSSLN-GQLES---NNN-YCIKEESG-ELEA- D----------------------------------------------------------- --------------------------------------------------------NP-- ------------------------------------N--------------SEPTILAES PVSSSR------------------------------------------------------ ------------------------------------------------DTKSPNKTSYL- ----------------------------------SMSTL-AKQEDEEFCILTNEDF---- ----------------------------------------------------ETCTDTEG -DGGDQTEE--------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------TQVPQSGS---------- -TE-------------------------------------------------PGSDDESE Y-----------------------------FEPA-------------------------- --------------------QNVPYYTLIFLTLLVYGYFILPWPTYVGGMLLGTGLGFLL AIGVVWLTGP---------------------------------K---------------- -------------S-SS-G-Y-----------RYF------------------------- ----------------KVRK-----------------LDIKQPEIYKGWMNEISNYDPET YHATLTHSVYVRLEGSTIRLSKPNHNISRRAAHND--LKPDVTFVSQKIYDLAYSKIHLV PEGLARKRIWNKKYPICIELGKQDDFMSR------------------------------- -TQGD------------------------------------------------------- ----------K-------------------------------WESIEG------------ SLTKDKTDGTVSTGNATLSQSV-------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------TLYLFGRTGREKEDWFQRFLEASK---------------------- -----------------------HKVDM-KKSASATVLKSTLLFVGGG------------ ------------------------------------------------------------ -------------------------H----------------SRS------------GSR SSLDEALLTQS--RPKDG----STS--TAG-S---------------------------- ---AKPSPLLDYSLYMANLL---------------------PN---------------QE AH-------------------SP----PSV-----CSS-L-------------------- ------------------------------------------------------------ ---------QSPMSSPGADKK---LPCSSPSPPEQ-NT--------G------------- --------------DEED-----PVAWLNAALGRIFWDFLREPYWADMVSKKIQMKLSKI RLPYFMNELTLTELDMGSSTPRILSGSKPYIDYKGLWFDLDVSYSGSFLMTLETKMNLIR LGKE--EESLRFGEPGKDGYRPRTYCLADSDEESSSAGSSDEEDTSE------------- --------L-SNDCT-------GAEGLVGGHRPSKIMRFVDKIAKSKYFQKATETEFIKK KMEEVSNTPLLLTVELQEVRGRLAVNIPPPPTDRIWYGFRTPPHLELKARPKLGERVVTL AHVTDWIEKKLDQEFQ-------------------------------------------- ------------------------------------------------------------ --------------------------------------------------KIFVMPNMDD VWLTIMHSAMDQRTAG-------------------------------------------- ----------------------------------------------------AGPVEDSE TSDPAS------------------------------------------------------ -ES------------------------- >ENSGWIP00000031641 ----------------------------M------------------------------- ------------------------------------------------------------ -------------------------------------------ASQL------------- -----------P-----------------SHEDGT---------PSSERPL--------P --------SMVPM-----------------------LHVQRSLSNEAITIHFSALGK-EE EEEE-----------------------E-E--LS-------------------------- ------------------------------------------------------------ ------S-----------------RSISAT-----SPSL--------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------DNTSIVT--------------AEEANEEM------------------- ----------------------------------FEGV---------------------- ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------VGGIPDSSRL---------------------- -----------------------SSLTA-------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------SPTQALSNHIPVEKA--------------------------------- ------------------------------------------------------------ ------------------------------------------------------SASL-- ---------------------------------------------------------SLP TK-------S-------------------SSFPS-------------------SDKPFL- R---------MVKSLSSD-GEVRDGVSS----------------------SLGS------ ------S-L-----RHR-QLMKSLVKSLSSDT-SQD----------------SSSS---- -----------SSTT---------S--HR-LNLQLFKQFTQSK----------MP-SA-- -TTSSSTASD-SKTAPSSPLTSL-DTR---SF-FKVADVEARLEDTKRRLSEAMSEPLQL LSKIIDEK-----------------------------------------------G---- SS----------LHRSKV-SSSGTELSTVASIN-GHLES---NNN-YCIKEEDSSVLDA- A----------------------------------------------------------- --------------------------------------------------------SP-- ------------------------------------S----------------------- --------SESSESSASP------------------------------------------ ----------------------------------------------SVDTKSQIKSSSL- ---------SK------------------TFDAYSMAAL-AKQEDEDFCILSTDDL---- ----------------------------------------------------D------- -----------L---------------------------VTQSNVVSGTDRIGRF----- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------SPTKVPLNGS---------- -VD-------------------------------------------------SDSEDESE S-----------------------------PQPA-------------------------- --------------------SGVPVFTLLALFLFVYGCFLVPLPIYIGGMLLGIALGFLL AIGVVWLTST---------------------------------K---------------- -------------S-SG-VDF-----------RRR-------------------RKLR-- ----------------NHSK-----------------LDIKEPEIYKGWMNEIQNYDPET YHTMLTQSVYVRLEGSVIRLSKPNRNIPRRAAHKEAKPKPDIFYISQKYYDMTNCKVYLS PPNLARKRIWNKKYPICIGLSKQDDFMSK------------------------------- -AEGE------------------------------------------------------- ----------K-------------------------------GEASDS------------ --TKDK------------------------EASGIP------------------------ ----------------------------------------------------------DR G----------------------------------------------------------- ---------SS------------------------------------------------- --------------------------------SSVDL----------------------- --------------TLYLFGRTGKEKEEWFHRFLFASK---------------------- -----------------------LK------------------------D---------- ----------------------------------------S-------------RKGACP SEPRM-------------A---LSTH----------------SRS------------NSH GSLDETLISPT--KSKDL----SASSAVAS-S---------------------------- ---PRAKPLLDYKVYMRSLL---------------------PK---------------ES KV-------------------SP----SAA-----SPV-L-------------------- ------------------------------------------------------------ ---------QSPQSSPGSDKK---L---------Q-STSSAQAPPSR------------- -----------E--EDES-----TVAWVNAALGRLFWDFLNEPYWGELVSKKIQMKLSKI RLPYFMEELTLTELDMGMVTPRILRASKPSVDYRGLWFDLEVSYQGSFLMTLETKMILNR LGKE--DEIKE--EFGKDGYRPRTYCLADSDDESSSAGSADEEDFSE------------- --------V-SSDTA-------GAESLVGGHKPSKIMRFVDKITKSKYFQKARETEFIKK KMEEVSNTPLLLTVELQQLQGTLTVNIPPPPTDRIWYGFRDPPQLELKARPKLGEREVTL GHVTDWIENKLDKEFQ-------------------------------------------- ------------------------------------------------------------ --------------------------------------------------KILVMPNMDD VWLPIMHSAFDSRTQD-------------------------------------------- ----------------------------------EPDVR--------------------- --------------------------------P-SLESETS-----------QPDEGSTS -QPD--------SV-SEM---------- >ENSHHUP00000091619 ----------------------------M------------------------------- ------------------------------------------------------------ -------------------------------------------ASCH------------- -----------S-----------------SHADNA-------------KAPPPSA--SRP --------PPVPK-----------------------LHVQGSLSRKSITIHFSPLGE-EE EEEE----------------------------LY-------------------------- ------------------------------------------------------------ ------G-----------------AVVSSPLPPAGP--K--------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------EDPGIVT--------------ALEASEDLI------------------ ----------------------------------LEGAGLD------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------SEAQAAVLP--------------------------- ----------------------------------------------------------M- SST----------------------------DPQS-----------------SITST--- --------------------------LLSEPK---------------------------- -------------------SSSP-------SPASNSK----------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------------------ST-- ---------------------------------------------------------SSP SK-------S-------------------------------------------SGKPFF- S---------LVKSLSSDIVE--------------------------------PSEIVSI SPAAPTS-V-----RHR-HPMKTLVKSLSSDT-SQE----------------SPPS---- -----------SSS----SPYRLSD--SR-LHLHLFKQFTQSR----------AP-VG-- -VVA---GGD-SKTAPSSTLTSP-DSR---NF-FK-ASVEASIEDTKRRFSEAIYEPLQL FNKIMEDKS---GG--I--------------------------------------G---- SS----------AFRSKALPSSASELTCLASLNNGQPES---NNN-YSIKEEET------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------RDDWESEGTGNGASSPNPTADTSHTRSPKMSSS A-----------------------SA---------------------------------- ---------SL------------------GLDKCSMSAL-AKLEDEDFCILSSEDF---- ----------------------------------------------------E---DTEG -DYVDRTDN--------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------TCSQVRLPPSGS---------- -PE-------------------------------------------------LCSDDKSE G-----------------------------EDPP-------------------------- --------------------PSIPHYTLIIITALVYGYFVLPLPTYVGGMLLGVGLGFML AIAVVWLAGP---------------------------------K---------------- -------------P-SG-YRT-----------KHS---------RHQ-------GKLW-- ----------------NMAQ-----------------LGIKEPNIFKGWMNEIVNYDPET YHATLTHSVYVRLEGSILRLSKPNHNIARRATHNE--SKPDVTYISQKIYDLTDSKIFLV PQSLARKRVWNKKYPICIELAKQDDFMSK------------------------------- -AEGD------------------------------------------------------- ----------R-------------------------------SE---------------- -------------------------------------------------TTHERT--TTT G------------------------------------------------EATAGTEEAKR S----------------------------------------------------------- ------------------------------------------------------------ --------------------------------SGPEL----------------------- --------------TLYLFGRTGREKEEWHRRILLASK---------------------- PPKTGMKRATSLQ-----------------------GIKTGEWM-----D---------- ------------------------------------------------------------ ----L-------------S---LSSH----------------SRS------------SSR SSLDEMLASQP--RTRDS---------TAGIA---------------------------- ---AKTKSLLDYSVYMATLV---------------------PT---------------ET GT-------------------ATATPIAAT-----SPV-V-------------------- ------------------------------------------------------------ ---------QSPQSSPGLGKK---L---------P-SSSS---------FGPVLVL---- --------------GEEE-----PVAWVNSVIGRVAWDFLGEPYWADVVSKKIQMKLSKI RLPYFMNELTLTELDMGVATPRILGASKPSVDHQGLWFDLEISYSGSFLMTLETKMNLIR LGKD--GDGVRIRDISKDGYRPRTYCLADSDEESSSAGSSDEEDTSE------------- --------V-TNDVP-------GAEGYMGGRQPSKIMRFVDKIAKSKYFQKATETEFIKK KMEEVSNTPLLLTVEVQELRGTLAVNIPPPPTDRIWYGFRSPPHLELKARPKLGEREVTL AHVTDWIEKKLDQEFQ-------------------------------------------- ------------------------------------------------------------ --------------------------------------------------KIFVMPNMDD LWLTIMHSAMDPRSFG-------------------------------------------- ----------------------------------TPSTST--ADTTQR------------ ------------------------------------ETEPS-----------ETERGATN ----------------GI---------- >ENSHHUP00000077849 ----------------------------M------------------------------- ------------------------------------------------------------ -------------------------------------------ASCH------------- -----------S-----------------SHADTA-------------KAPPPSA--TRP --------SAMPK-----------------------LHVQGSLSRKSITIHFSPLGE-EE EEEE----------------------------LY-------------------------- ------------------------------------------------------------ ------G-----------------AVVSSPLPTAGP--I--------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------EDPGIVT--------------ALEISEDLI------------------ ----------------------------------LDGAGLD------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------SEGQAAVLP--------------------------- ----------------------------------------------------------ML SST----------------------------GPQS-----------------SITST--- --------------------------LPSEPK---------------------------- -------------------SSSP-------SPASTSK----------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------------------ST-- ---------------------------------------------------------S-- SK-------S-------------------------------------------SDKPFF- S---------LVKSLSSDIIE--------------------------------PSENVSI SPAAPTS-V-----RPR-HLMKTLVKSLSSDT-TQE----------------SPPS---- -----------SSS----SPYRLSD--SR-LNLHLFKQFTQSR----------AP-VG-- -VVA---GGD-SKTAPSSTLTSP-DSR---NF-FK-ASVEASIEDTKRRFSEAIYEPLQL FNKIMEDKS---GG--I--------------------------------------G---- SS----------AFRSKALSSSASELTCLASLNNGQPES---NNN-YSIKEEET------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------VDDWGSEGTRNGASSPNPTSD---TRSPKMSSS A-----------------------SA---------------------------------- ---------SL------------------GLDMCSMSAL-SKMEDEDFCILSSEDF---- ----------------------------------------------------E---DTEG -DYGDKTDN--------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------TCSQVRLLPSGS---------- -PE-------------------------------------------------LCSDDKSE G-----------------------------EDPP-------------------------- --------------------PSIPYYTLIILTALVYGYFVLPLPTYVGGMLLGVGLGFML AIAVVWLAGP---------------------------------K---------------- -------------P-SG-NRT-----------RHP---------RHQ-------GKLW-- ----------------NMAQ-----------------LGIKEPSIFKGWMNEIVNYDPET YHATLTHSVYVRLEGSILRLSTPNRNIARRATHNE--PKPDVTYISQKIYDLTDSKIYLV PQSLARKRVWNKKYPIRIKLAKQDDFMSK------------------------------- -AEGD------------------------------------------------------- ----------R-------------------------------SE---------------- -------------------------------------------------VTHERTTATAT G------------------------------------------------EATVGTEEAKR S----------------------------------------------------------- ------------------------------------------------------------ --------------------------------GGPEL----------------------- --------------TLYLFGRTGREKEEWHRRILLASK---------------------- PPKTGMKRVTGLQ-----------------------GSKT-------------------- ------------------------------------------------------------ ------------------A---LSSH----------------SRS------------SSR SSLDEMLASQP--RTRDS---------TAGIV---------------------------- ---AKTKSLLDYSVYMATLI---------------------PP---------------ET GT-------------------ATATPIAAT-----SPV-V-------------------- ------------------------------------------------------------ ---------QSPQSSPGSGKN---L---------Q-SSSS---------FGPVVML---- --------------GEEE-----PVAWVNSVIGRVAWDFLGEPYWADVVSKKIQMKLSKI RLPYFMNELTLTELDMGVATPRILGASKPSVDHQGLWFDLEISYSGSFLMTLETKMNLIR LGKD--GDCMRIRDISKDGYRPRTYCLADSDEESSSAGSSDEEDTSE------------- --------F-TNDVS-------GAEGYMGGRQPSKIMRFVDKIAKSKYFQKATETEFIKK KMEEVSNTPLLLTVEVQELRGTLAVNIPPPPTDRIWYGFRSPPHLELKARPKLGEREVTL AHVTDWIEKKLDQEFQ-------------------------------------------- ------------------------------------------------------------ --------------------------------------------------KIFVMPNMDD LWLTIMHSAMDPRSFG-------------------------------------------- ----------------------------------TP--ST--ADTTQR------------ ------------------------------------ETEPS-----------ETEGCATN ----------------AI---------- >ENSELUP00000013547 ----------------------------M------------------------------- ------------------------------------------------------------ -------------------------------------------TSRR------------- -----------S----------------ISHADKA-------------KAPPPSA--SRP --------PAVPK-----------------------LHVQGSLSRESITIHFSALGK-EE EEEE-----------------------E-N--LY-------------------------- ------------------------------------------------------------ ------G-----------------MAVSSP-----PNVK--------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------EDPGVVT--------------ALEASEELI------------------ ----------------------------------LEGAGMD------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------PEAEAAVL---------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------SVSTSTERKSSFALAPEQKSLATPSAFTSSTPFSALSSSTTSKLSDKPFF- G---------LVKSLSSDIVE--------------------------------PSEIVSV STAAPAS-V-----RHR-HLMKTLVKSLSSDT-SQD------------------------ ------------SA----SPYRGSD--SR-LNLHLFKQFTQCR----------VP-VG-- -VVS---GGD-SKTAPSSPLTSP-DSR---N--FK-ASVEASIEDTKRRFSEAIYEPLQL FNKIMGDES---GG--V--------------------------------------G---- SS----------PFRSKALSSSASELTNLASFNSVQPES---NNNSYTIKEEDA------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------DCDWESDETATSAGSPNPSAETSRTRSPKMYSS I-----------------------SA---------------------------------- ---------SL------------------GLDKCSMSAL-AKLEEDDFCILSSEDF---- ----------------------------------------------------E---ETEE -DSVERTDH--------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------SGGRVRRPPSGS---------- -TE-------------------------------------------------LCSGDESE E-----------------------------GVPS-------------------------- --------------------PSVPHYTLIFLTVLVYGFFVLPLPTYVSGMFTGVALGFML AVAVVWLAGP---------------------------------K---------------- -------------P-SG-HSL-----------RHP---------RRH-------GELW-- ----------------SPAR-----------------LDIKEPGIFKSWMNEIMNYDPET YHATLTHSVFVRLEGSVLRLSKPNHNIARRATHNE--PKPDVTYISQKIYDLTNSKIYLV PQSLARKRVWNKKYPICIELAKQDDFMSK------------------------------- -AEGD------------------------------------------PSDPADPGTAAAG EGDETKRPCC-------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------PEL----------------------- --------------TLYLFGRTGREKEEWYRRLLLASK---------------------- PVKTETKAAISQQ-----------------------GSKT-------------------- ------------------------------------------------------------ ------------------A---LSSH----------------SRS------------SSR GSLDEALGSQP--WSRDP---------TAGAA---------------------------- ---LKPKPLLDYNVYMATLV---------------------PP---------------EN AA-------------------STATPVAAA-----NPV-I-------------------- ------------------------------------------------------------ ---------QSPQSSPGAGKK---L---------PSSSSS---------IGFVVAR---- --------------GEEE-----PVAWVNSVIGRVAWDFLGEPYWADVVSKKIQMKLSKI RLPYFMNELTLTELDMGVSTPRILSASKPSVDHQGLWFDLEISYSGSFLMTLETKMNLIR LGKE--EEGLRVGDSGKEGYRPRTYCLADSDEESSSAGSSDEEDTSE------------- --------I-PGDIP-------GAEGHMAGRQPSKIMRFVNKIAKSKYFQKATETEFIKK KMEEVSNTPLLLTVEVQELRGTLAVNIPPPPTDRIWYGFRSPPHLELKARPKLGEREVTL AHVTDWIEKKLDQEFQ-------------------------------------------- ------------------------------------------------------------ --------------------------------------------------KVFVMPNMDD VWLTIMHSAMDSRSSG-------------------------------------------- ----------------------------------GPSASTSMADSAQR------------ ------------------------------------DPEPS-----------QTEGDAIG ----------------DV---------- >ENSPREP00000009264 ---------------------------MM------------------------------- ------------------------------------------------------------ -------------------------------------------SSQG------------- ------------------NN----RKGSGQHADTP-P--------------------LRH --------APGPK-----------------------LQVQRSHSRDTITIHFSALGK-EE EDEE-----------------------E-E--LY-------------------------- ------------------------------------------------------------ ------G-----------------L----------------------------------- --------------------------------------------------------SVEC AAAKTVLDGAAG-------------------PQS-------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -------QSTGTDGQSVAK--------------GLEAKEE-------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------LGLE--------------------------SADAETFSGSL------ --------------MPVSAAILPPQPLDLHP----------------------------- -HTPSLAMTVNPVXTHSHLSSTS----------------------------PAS------ --------------------------------------------------SSWA------ -----------------------------SD--------------------RP-AQ---- ------------------------------------------------------------ --------------------------------------------------PPLISSTS-- ---------------------------------------------------------SSP CK-------S-------------------TALSS--------------------SKPFL- S---------LVRSLSND-VDSRETAPV----------IAT---------VVPP------ ------H-A-----RHR-HLMKSFVKSLSTDT-SKGEHHEGPLQH--------------- ---HSHH-QQTQPT------HRTPP-----RNMQLFKQFSQPR----------LS-SCPV AVTQA--GGD-SKTAPSSPIMSP-DGR---SF-FKVQEVEARIEDTKRRLSEVMSDPLQL FSKIIGDES---SVGPX--------------------------------------G---- SA----------AHRAKSLSSSASELSGVTAVN-GHTEA---NNN-YSIK-EEGA--EG- E--------------------E--XEETPTEKG--------------------------- ---------------------------------------------------------P-- ----------------------------------------------ESSFFS-------- ------------------------------------------------------------ ----FPSLSLAPALTQASSSTLHRS----------------------------------- --------PSL------------------TLGRCSMSALVARQEDEDFCELYSEDF---- ----------------------------------------------------ELCTDTET PDG--------------------------------------------------------- ----------------------ERSMSQQPHTGSTGLGSELDA----------------- ------------------------------------------------------------ -----------------------------------------------------------E DEGL-------------------------------------------------------- ------------------------------------------------------------ ---------------------------------------------------------V-- ---DEM--------------ENVPVTGLIFLTQLLYLYLVLPVPPCVCSVLHGIVAGFML ALLVLWLSAP---------------------------------R---------------- -------------C-SS-SGT-----------RTR---------RWR-------KDQR-- ----------------NV-------------------LNVKEPGIFKGWMNEIQSYDPEM YHATLTHSVYVRLEGSVLRLSKPNRNISRRAAHNE--PKPDVTYISQKIYDLTDSRIYLM PQSLARKRVWNKKYPICIELAKQEDFMSK------------------------------- -AEGE------------------------------------------------------- ----------R-------------------------------SEAGDER----------- ------------------------------------------------------------ --------------------------------TTGLCEKLERTDKAEKAEVCTSAEEQRR P----------------------------------------------------------- ---------TA--GG-------------------G------------------------- -----------------------------------DL----------------------- --------------TIYLFGRTGREKEEWFQRFLQASH---------------------- -----------------------MKSEG-------------------------------R GG--SLS----GICK-------------------------S------------------- ------------------A--FLSAHSRSGSIQSG-GGPEADSRG------------SSR GSQEEL--SQP--RHRE--TPASLSGGSAG-G---------------------------- ---MKQKMLLDYNIYMAKYV---------------N-----PQ----------------- ---------------AP--PGSP----TAAD----SPG---------------------- ------------------------------------------------------------ ---------HTPESSPKATKK---L---------P-RS---------------------- ----------SE--EAAE-----PEAWVNAFLGRIFWDFLREKYWADVVSKKIQMKLSKI RLPYVMNELTLTELDMGFSVPKILRASKPSVDHQGLWFDLEVSYTGSFLMTLETKLNLAR LGKE--GEGL--GDHGKEWSRPRTYCLADSDEESSSAGSSDEEDPPE------------- --------L-LSDKPSLP----ASEGYVGGHRPSKIMRFVDKIAKSKYFQKATETEFIKK KMEEVSNTPLLLTVEVQECRGTLAVNIPPPPTDRIWYGFRSPPHLELKARPKLGEREVTL VHVTEWIEKKLDQEFQ-------------------------------------------- ------------------------------------------------------------ --------------------------------------------------KIFVMPNMDD IWLPIMHSAMDMRSNA-------------------------------------------- ------------------------------------------------------------ ---------------NL-T--VTNDDLKD---P-----EPE------------------- ---------ES-EL-SDV---------- >ENSPLAP00000011656 ---------------------------MM------------------------------- ------------------------------------------------------------ -------------------------------------------SSQG------------- ------------------NS----RKGSGQHADTP-P--------------------LRH --------APGPK-----------------------LQVQRSHSRDTITIHFSALGK-EE EDEE-----------------------E-E--LY-------------------------- ------------------------------------------------------------ ------G-----------------L----------------------------------- --------------------------------------------------------SVEC AAAKSVLDGAAG-------------------PQS-------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -------QSTGTDGQSVAK--------------GLDAKEE-------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------LGLE--------------------------SVDVETFSGSL------ --------------MPVSAAILPAQPLDSHP----------------------------- -HTPSLAMTVNPVSTHSHLSSTS----------------------------PAS------ --------------------------------------------------SSWA------ -----------------------------SD--------------------RP-AQ---- ------------------------------------------------------------ --------------------------------------------------PPLISSTS-- ---------------------------------------------------------SSP CK-------S-------------------AALSS--------------------SKPFL- S---------LVRSLSND-VDSRETAPV----------IAT---------VVPP------ ------H-A-----RHR-HLMKSFVKSLSTDT-SKGEHHEGPLQH--------------- ---HSHH-QQTQPT------HRTPP-----RNMQLFKQFSQPR----------LS-SCPV AVTQA--GGD-SKTAPSSPIMSP-DGR---SF-FKVQEVEARIEDTKRRLSEVMSDPLQL FSKIIGDES---SVGPA--------------------------------------G---- SA----------AHRGKSLSSSASELSGVTAVN-GHTEA---NNN-YSIK-EEGA----- ---------------------E--EEETPTEKG--------------------------- ---------------------------------------------------------P-- ----------------------------------------------DSSFFS-------- ------------------------------------------------------------ ----FPSLSLAPALTQASSSTLHRS----------------------------------- --------PSL------------------TLGRCSMSALVARQEDEDFCELYSEDF---- ----------------------------------------------------ELCTDTET PDG--------------------------------------------------------- ----------------------ERSISQQPHTGSTGLGSELDA----------------- ------------------------------------------------------------ -----------------------------------------------------------E DEGL-------------------------------------------------------- ------------------------------------------------------------ ---------------------------------------------------------V-- ---EEM--------------ENVPVTGLIFLTQLLYLYLVLPVPPCVCSVLHGIVVGFML ALLVLWLSAP---------------------------------R---------------- -------------C-SS-SGT-----------RTR---------RWR-------KDQR-- ----------------NVPQ-----------------LDVKEPGIFKGWMNEIQSYDPEM YHATLTHSVYVRLEGSVLRLSKPNRNISRRAAHNE--PKPDVTYISQKIYDLTDSRIYLM PQSLARKRVWNKKYPICIELAKQEDFMSK------------------------------- -AEGE------------------------------------------------------- ----------R-------------------------------SEAGDER----------- ------------------------------------------------------------ --------------------------------TTGLCEKLERTDKAEKAEVCTSAEEQRR P----------------------------------------------------------- ---------TT--GG-------------------G------------------------- -----------------------------------DL----------------------- --------------TIYLFGRTGREKEEWFRRFLQASQ---------------------- -----------------------MKSEG-------------------------------R GG--SLS----GICK-------------------------S------------------- ------------------A--FLSAHSRSGSIQSG-GGPEADSRG------------SSR GSQEEL--SQP--RHRE--TPASLSGGSAG-G---------------------------- ---MKQKMLLDYNIYMAKYV---------------N-----PQ----------------- ---------------AP--PGSP----TAPD----SPG---------------------- ------------------------------------------------------------ ---------HTPESSPKATKK---L---------P-RS---------------------- ----------SE--EAAE-----PEAWVNAFLGRTFWDFLREKYWADVVSKKIQMKLSKI RLPYVMNELTLTELDMGFSVPKILRASKPSVDHQGLWFDLEVSYTGSFLMTLETKLNLVR LGKE--GEGL--GDHGKEWSRPRTYCLADSDEESSSAGSSDEEDPPE------------- --------L-LSDKPNLP----ASEGYVGGHRPSKIMRFVDKIAKSKYFQKATETEFIKK KMEEVSNTPLLLTVEVQECRGTLAVNIPPPPTDRIWYGFRSPPHLELKARPKLGEREVTL VHVTEWIEKKLDQEFQ-------------------------------------------- ------------------------------------------------------------ --------------------------------------------------KIFVMPNMDD IWLPIMHSAMDMRSNA-------------------------------------------- ------------------------------------------------------------ ---------------NL-T--VTNDALKD---P-----GPE------------------- ---------ES-EL-SDV---------- >ENSPFOP00000007263 ---------------------------MM------------------------------- ------------------------------------------------------------ -------------------------------------------SSQG------------- ------------------NS----RKGSGQHADTP-P--------------------LRH --------APGPK-----------------------LQVQRSHSRDTITIHFSALGK-EE EDEE-----------------------E-E--LY-------------------------- ------------------------------------------------------------ ------G-----------------L----------------------------------- --------------------------------------------------------SVEC AAAKSVLDGAAG-------------------PQS-------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -------QSTGTDGQSVAK--------------GLDAKEE-------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------LGLE--------------------------SVDVETFSGSL------ --------------MPVSAAILPAQPLDSHP----------------------------- -HTPSLAMTVNPVSTHSHLSSTS----------------------------PAS------ --------------------------------------------------SSWA------ -----------------------------SD--------------------RP-AQ---- ------------------------------------------------------------ --------------------------------------------------PPLISSTS-- ---------------------------------------------------------SSP CK-------S-------------------AALSS--------------------SKPFL- S---------LVRSLSND-VDSRETAPV----------IAT---------VVPP------ ------H-A-----RHR-HLMKSFVKSLSTDT-SKGEHHEGPLQH--------------- ---HSHH-QQTQPT------HRTPP-----RNMQLFKQFSQPR----------LS-SCPV AVTQA--GGD-SKTAPSSPIMSP-DGR---SF-FKVQEVEARIEDTKRRLSEVMSDPLQL FSKIIGDES---SVGPA--------------------------------------G---- SA----------AHRGKSLSSSASELSGVTAVN-GHTEA---NNN-YSIK-EEGA----- ---------------------E--EEETPTEKG--------------------------- ---------------------------------------------------------P-- ----------------------------------------------DSSFFS-------- ------------------------------------------------------------ ----FPSLSLAPALTQASSSTLLRS----------------------------------- --------PSL------------------TLGRCSMSALVARQEDEDFCELYSEDF---- ----------------------------------------------------ELCTDTET PDG--------------------------------------------------------- ----------------------ERSISQQPHTGSTGLGSELDA----------------- ------------------------------------------------------------ -----------------------------------------------------------E DEGL-------------------------------------------------------- ------------------------------------------------------------ ---------------------------------------------------------V-- ---EEM--------------ENVPVTGLIFLTQLLYLYLVLPVPPCVCSVLHGIVVGFML ALLVLWLSAP---------------------------------R---------------- -------------C-SS-SGT-----------RTR---------RWR-------KDQR-- ----------------NVPQ-----------------LDVKEPGIFKGWMNEIQSYDPEM YHATLTHSVYVRLEGSVLRLSKPNRNISRRAAHNE--PKPDVTYISQKIYDLTDSRIYLM PQSLARKRVWNKKYPICIELAKQEDFMSK------------------------------- -AEGE------------------------------------------------------- ----------R-------------------------------SEAGDER----------- ------------------------------------------------------------ --------------------------------TTGLCEKLERTDKAEKAEVCTSAEEQRR P----------------------------------------------------------- ---------TT--GG-------------------G------------------------- -----------------------------------DL----------------------- --------------TIYLFGRTGREKEEWFRRFLQASQ---------------------- -----------------------MKSEG-------------------------------R GG--SLS----GICK-------------------------S------------------- ------------------A--FLSAHSRSGSIQSG-GGPEADSRG------------SSR GSQEEL--SQP--RHRE--TPASLSGGSAG-G---------------------------- ---MKQKMLLDYNIYMAKYV---------------N-----PQ----------------- ---------------AL--PGSP----TAPD----SPG---------------------- ------------------------------------------------------------ ---------HTPESSPKATKK---L---------P-RS---------------------- ----------SE--EAAE-----PEAWVNAFLGRTFWDFLREKYWADVVSKKIQMKLSKI RLPYVMNELTLTELDMGFSVPKILRASKPSVDHQGLWFDLEVSYTGSFLMTLETKLNLVR LGKE--GEGL--GDHGKEWSRPRTYCLADSDEESSSAGSSDEEDPPE------------- --------L-LSDKPNLP----ASEGYVGGHRPSKIMRFVDKIAKSKYFQKATETEFIKK KMEEVSNTPLLLTVEVQECRGTLAVNIPPPPTDRIWYGFRSPPHLELKARPKLGEREVTL VHVTEWIEKKLDQEFQ-------------------------------------------- ------------------------------------------------------------ --------------------------------------------------KIFVMPNMDD IWLPIMHSAMDMRSNA-------------------------------------------- ------------------------------------------------------------ ---------------NL-T--VTNDALKD---P-----EPE------------------- ---------ES-EL-SDV---------- >ENSPMEP00000030131 ---------------------------MM------------------------------- ------------------------------------------------------------ -------------------------------------------SSQG------------- ------------------NS----RKGSGQHADTP-P--------------------LRH --------APGPK-----------------------LQVQRSHSRDTITIHFSALGK-EE EDEE-----------------------E-E--LY-------------------------- ------------------------------------------------------------ ------G-----------------L----------------------------------- --------------------------------------------------------SVEC AAAKSVLDGAVG-------------------PQS-------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -------QSTGTDGQSVAK--------------GLEAKEE-------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------LGLE--------------------------SVDAETFSGSL------ --------------MPVSAAILPAQPLGSHP----------------------------- -HTPSLAMTVNPVSTHSHLSSTS----------------------------PAS------ --------------------------------------------------SSWA------ -----------------------------SD--------------------RP-AQ---- ------------------------------------------------------------ --------------------------------------------------PPLISSTS-- ---------------------------------------------------------SSP CK-------S-------------------AAPSS--------------------SKPFL- S---------LVRSLSND-VDSRETAPV----------IAT---------VVPP------ ------H-A-----RHR-HLMKSFVKSLSTDT-SKGEHHEGPLQH--------------- ---HSHH-QQTQPT------HRTPP-----RNMQLFKQFSQPR----------LS-SCPV TVTQA--GGD-SKTAPSSPIMSP-DGR---SF-FKVQEVEARIEDTKRRLSEVMSDPLQL FSKIIGDES---SVGPA--------------------------------------G---- SA----------AHRGKSLSSSASELSGVTAVN-GHTEA---NNN-YSIK-EEGA--EG- E--------------------E--EEETPTEKG--------------------------- ---------------------------------------------------------P-- ----------------------------------------------DSSFFS-------- ------------------------------------------------------------ ----FPSLSLAPALTQASSSTLLRS----------------------------------- --------PSL------------------TLGRCSMSALVARQEDEDFCELYSEDF---- ----------------------------------------------------ELCTDTET PDG--------------------------------------------------------- ----------------------ERSISQQPHTGSTGLGSELDA----------------- ------------------------------------------------------------ -----------------------------------------------------------E DEGL-------------------------------------------------------- ------------------------------------------------------------ ---------------------------------------------------------V-- ---EEM--------------ENVPVTGLIFLTQLLYLYLVLPVPPCVCSVLHGIVVGFML ALLVLWLSAP---------------------------------R---------------- -------------C-SS-SGT-----------RTR---------RWR-------KDQR-- ----------------NVPQ-----------------LDVKEPGIFKGWMNEIQSYDPEM YHATLTHSVYVRLEGSVLRLSKPNRNISRRAAHNE--PKPDVTYISQKIYDLTDSRIYLM PQSLARKRVWNKKYPICIELAKQEDFMSK------------------------------- -AEGE------------------------------------------------------- ----------R-------------------------------SEAGDER----------- ------------------------------------------------------------ --------------------------------TTGLCEKLERTDKAEKAEVCTSAEEQRR P----------------------------------------------------------- ---------TA--GG-------------------G------------------------- -----------------------------------DL----------------------- --------------TIYLFGRTGREKEEWFRRFLQASQ---------------------- -----------------------MKSEG-------------------------------R GG--SLS----GICK-------------------------S------------------- ------------------A--FLSAHSRSGSIQSG-GGPEADSRG------------SSR GSQEEL--SQP--RHRE--TPASLSGGSAG-G---------------------------- ---MKQKMLLDYNIYMAKYV---------------N-----PQ----------------- ---------------AL--PGSP----TAPD----SPG---------------------- ------------------------------------------------------------ ---------HTPESSPKATKK---L---------P-RS---------------------- ----------SE--EAAE-----PEAWVNAFLGRIFWDFLREKYWADVVSKKIQMKLSKI RLPYVMNELTLTELDMGFSVPKILRASKPSVDHQGLWFDLEVSYTGSFLMTLETKLNLAR LGKE--GEGL--GDHGKEWSRPRTYCLADSDEESSSAGSSDEEDPPE------------- --------L-LSDKPNLP----ASEGYVGGHRPSKIMRFVDKIAKSKYFQKATETEFIKK KMEEVSNTPLLLTVEVQECRGTLAVNIPPPPTDRIWYGFRSPPHLELKARPKLGEREVTL VHVTEWIEKKLDQEFQ-------------------------------------------- ------------------------------------------------------------ --------------------------------------------------KIFVMPNMDD IWLPIMHSAMDMRSNA-------------------------------------------- ------------------------------------------------------------ ---------------NL-T--VTNDALKD---P-----EPE------------------- ---------ES-EL-SDV---------- >ENSXMAP00000001294 ----------------------------M------------------------------- ------------------------------------------------------------ -------------------------------------------SSHG------------- ------------------NS----RKGSGQHADT--P--------------------LRH --------APGPK-----------------------LQVQRSHSRDTITIHFSALGK-EE EDEE-----------------------E-E--LY-------------------------- ------------------------------------------------------------ ------G-----------------L----------------------------------- --------------------------------------------------------SVEC AAAKSVLDGAAG-------------------PQS-------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -------QSTGTDGQSLAK--------------GLEAEEK-------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------LGLE--------------------------SVDAEIFSGSL------ --------------LPVSSAILPAQPLDSHP----------------------------- -HTPSLAMTVNPVSTHSHLSSTS----------------------------PAS------ --------------------------------------------------SSWA------ -----------------------------SD--------------------RP-AQ---- ------------------------------------------------------------ --------------------------------------------------PPLISSTS-- ---------------------------------------------------------SSP CK-------S-------------------AALSS--------------------SKPFL- S---------LVRSLSND-VDSRETAPV----------IAT---------VVPP------ ------H-A-----RHR-HLMKSFVKSLSTDT-SKGEHHEGPLQH--------------- ---HSHH-QQTQPT------HRTPP-----RNMQLFKQFSQPR----------LS-SCPV AVTQA--GGD-SKTAPSSPIMSP-DGR---SF-FKVQEVEARIEDTKRRLSEVMSDPLQL FSKIIGDES---GVGLT--------------------------------------G---- SA----------AHRAKSLSSSASELSGVTAVN-GHTEA---NNN-YSIK-EEGA--EG- E--------------------E--EEETPTEKG--------------------------- ---------------------------------------------------------P-- ----------------------------------------------DSSFFS-------- ------------------------------------------------------------ ----FPSLSLAPALTQASSSTLHRS----------------------------------- --------PSL------------------TLGRCSMSALVARQEDEDFCELYSEDF---- ----------------------------------------------------ELCTDTET PDG--------------------------------------------------------- ----------------------ERSMSQQPHTGSTGLGSELDA----------------- ------------------------------------------------------------ -----------------------------------------------------------E DEGL-------------------------------------------------------- ------------------------------------------------------------ ---------------------------------------------------------V-- ---EEM--------------ENVPVTGLIFLTQLLYLYLVLPVPPCLCSVLHGIVVGFML ALLVLWLSAP---------------------------------R---------------- -------------C-SS-SGT-----------RTR---------RWR-------KDQR-- ----------------NVPQ-----------------LDVKEPGIFKGWMNEIQSYDPEM YHATLTHSVYVRLEGSVLRLSKPNRNISRRAAHNE--PKPDVTYISQKIYDLTDSRIYLM PQSLARKRVWNKKYPICIELAKQEDFMSK------------------------------- -AEGE------------------------------------------------------- ----------R-------------------------------SEAGDER----------- ------------------------------------------------------------ --------------------------------TTGLGEKLERTDKAEKAEVCTSAEEQRR P----------------------------------------------------------- ---------TA--GG-------------------G------------------------- -----------------------------------DL----------------------- --------------TIYLFGRTGREKEEWFRRFLQASQ---------------------- -----------------------MKSEG-------------------------------R GG--SLS----GICK-------------------------S------------------- ------------------A--FLSAHSRSGSIQSA-GGPEADSRG------------SSR GSQEEL--SQP--RHRE--TPASLSSGSAG-G---------------------------- ---MKQKMLLDYSIYMAKYV---------------N-----PQ----------------- ---------------AP--PGSP----PAVD----SPG---------------------- ------------------------------------------------------------ ---------HTPESSPKATKK---L---------P-RS---------------------- ----------SE--EAAE-----PEAWVNAFLGRIFWDFLREKYWADVVSKKIQMKLSKI RLPYVMNELTLTELDMGFSVPKILRASKPSVDHQGLWFDLEVSYTGSFLMTLETKLNLAR LGKE--GEGL--GDHGKEWSRPRTYCLADSDEESSSAGSSDEEDPPE------------- --------L-LSDKPNLP----ASEGYVGGHRPSKIMRFVDKIAKSKYFQKATETEFIKK KMEEVSNTPLLLTVEVQECRGTLAVNIPPPPTDRIWYGFRSPPHLELKARPKLGEREVTL VHVTEWIEKKLDQEFQ-------------------------------------------- ------------------------------------------------------------ --------------------------------------------------KIFVMPNMDD IWLPIMHSAMDMRSNA-------------------------------------------- ------------------------------------------------------------ ---------------NL-T--LTNDALKD---P-----EPE------------------- ---------ES-EV-SDV---------- >ENSGAFP00000030028 ----------------------------M------------------------------- ------------------------------------------------------------ -------------------------------------------SSHS------------- ------------------NS----RKGSGQHADTP-P--------------------LRH --------APGPK-----------------------LQVQRSHSRDTITIHFSALGK-EE EDEE-----------------------E-E--LY-------------------------- ------------------------------------------------------------ ------G-----------------L----------------------------------- --------------------------------------------------------SVEC AAATSVLDGAAG-------------------PQS-------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -------QSTGTDGQSLAK--------------GLESKEE-------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------LGLE--------------------------SVDAEIFSGSL------ --------------MPVSSAILPAQPLDSHP----------------------------- -HTPSLAMTVNPVSTHSHLSSTS----------------------------PAS------ --------------------------------------------------SSWA------ -----------------------------SD--------------------RP-AQ---- ------------------------------------------------------------ --------------------------------------------------PALISSTS-- ---------------------------------------------------------SSP CK-------S-------------------AALSS--------------------SKPFL- S---------LVRSLSND-VDSRETAPV----------IAT---------VAPP------ ------H-P-----RHR-HLMKSIVKSLSTDT-SKGEHHEGPLQH--------------- ---HSHH-QQTQPT------HRTPP-----RNMQLFKQFSQPR----------LS-SCPV AVTQA--GGD-SKTAPSSPIMSP-DGR---SF-FKVQEVEARIEDTKRRLSEVMSDPLQL FSKIIGDES---GVGLA--------------------------------------G---- SA----------AHRAKSLSSSASELSGVTAVN-GHTEA---NNN-YSIK-EEGA--EG- E--------------------E--EEETPTEKG--------------------------- ---------------------------------------------------------P-- ----------------------------------------------DSSFFS-------- ------------------------------------------------------------ ----FPSLSLAPALTQASSATLYRS----------------------------------- --------PSL------------------TLGRCSMSALVARQEDEDFCELYSEDF---- ----------------------------------------------------DLCTDTET PDG--------------------------------------------------------- ----------------------ERSMSQQPHTGSTGLGSELDA----------------- ------------------------------------------------------------ -----------------------------------------------------------E DEGL-------------------------------------------------------- ------------------------------------------------------------ ---------------------------------------------------------V-- ---EEM--------------ENVPVTGLIFLTQLLYLYLVLPVPPCVCSVLHGIVVGFML ALLVLWLSAP---------------------------------R---------------- -------------C-SS-SGT-----------RTR---------RWR-------KDQR-- ----------------NVPQ-----------------LDVKEPGIFKGWMNEIQCYDPEM YHATFTHSVYVRLEGSVLRLSKPNRNISRRAAHNE--PKPDVTYISQKIYDLTDSRIYLM PQSLARKRVWNKKYPICIELAKQEDFMSK------------------------------- -AEGE------------------------------------------------------- ----------R-------------------------------SEAGNER----------- ------------------------------------------------------------ --------------------------------TTGLVEKLERTDKAEKAEVCTSVEEQRR P----------------------------------------------------------- ---------TA--GG-------------------G------------------------- -----------------------------------DL----------------------- --------------TIYLFGRTGREKEEWFRRFLQASQ---------------------- -----------------------MKSEG-------------------------------R GG--TLS----GICK-------------------------S------------------- ------------------A--FLSAHSRSGSIQSA-GGPEADSRG------------SSR GSQEEL--SQP--RHRE--TPASLSSGSAG-G---------------------------- ---MKQKMLLDYNIYMAKYV---------------N-----PQ----------------- ---------------AP--PGSP----TAVD----SPG---------------------- ------------------------------------------------------------ ---------QTPESSPKATKK---L---------P-KS---------------------- ----------SE--EAAE-----PEAWVNTFLGRIFWDFLREKYWANVVSKKIQMKLSKI RLPYVMNELTLTELDMGFSVPKILRASKPSVDHQGLWFDLEVSYTGSFLMTLETKLNLVR LGKE--GEGL--GDHGKEWSRPRTYCLADSDEESSSAGSSDEEDPPE------------- --------L-LSDKPNLP----ASEGYVGGHRPSKIMRIVDKIAKSKYFQKATETEFIKK KMEEVSNTPLLLTVEVQECRGTLAVNIPPPPTDRIWYGFRSPPHLELKARPKLGEREVTL VHVTEWIEKKLDQEFQ-------------------------------------------- ------------------------------------------------------------ --------------------------------------------------KIFVMPNMDD IWLPIMHSAMDMRSNA-------------------------------------------- ------------------------------------------------------------ ---------------NL-T--VTNDALKD---P-----EPE------------------- ---------ES-EV-SDV---------- >ENSXCOP00000013643 ---------------------------HT------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -------------------S----KKGSGQHADT--P--------------------LRH --------APGPK-----------------------LQVQRSHSRDTITIHFSALGK-EE EDEE-----------------------E-E--LY-------------------------- ------------------------------------------------------------ ------G-----------------L----------------------------------- --------------------------------------------------------SVEW ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------TDGQSLAK--------------GLEAEEE-------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------LGLE--------------------------SVDAEIFSGSL------ --------------LPVSSAILPAQPLDSHP----------------------------- -HTPSLAMTVNPVSTHSHLSSTS----------------------------PAS------ --------------------------------------------------SSWA------ -----------------------------SD--------------------RP-AQ---- ------------------------------------------------------------ --------------------------------------------------PPLISSTS-- ---------------------------------------------------------SSP CK-------S-------------------AALSS--------------------SKPFL- S---------LVRSLSND-VDSRETAPV----------IAT---------VVPP------ ------H-A-----RHR-HLMKSFVKSLSTDT-SKGEHHEGPLQH--------------- ---HSHH-QQTQPT------HRTPP-----RNMQLFKQFSQPR----------LS-SCPV TVTQA--GGD-SKTAPSSPIMSP-DGR---SF-FKVQEVEARIEDTKRRLSEVMSDPLQL FSKIIGDES---GVGLA--------------------------------------G---- SA----------AHRAKSLSSSALELSGVTAVN-GHTEA---NNN-YSIK-EEGA--EG- E--------------------E--EEETPTEK---------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------ALTQASSSTLHRS----------------------------------- --------PSL------------------TLGRCSMSALVARQEDEDFCELYSEDF---- ----------------------------------------------------ELCTDTET PDG--------------------------------------------------------- ----------------------EQSMSQQPHTGSTGLGSELDA----------------- ------------------------------------------------------------ -----------------------------------------------------------E DEGL-------------------------------------------------------- ------------------------------------------------------------ ---------------------------------------------------------V-- ---EEL--------------ENVPMTGLIFLTQLLYLYLVLPVPPCLCSVLHGIVVGFML ALLVLWLSAP---------------------------------R---------------- -------------C-SS-SGT-----------RTR---------RWR-------KDQR-- ----------------NVPQ-----------------LDVKEPGIFKGWMNEIQSYDPEM YHATLTHSVYVRLEGSVLRLSKPNRNISRRAAHNE--PKPDVTYISQKIYDLTDSRIYLM PQSLARKRVWNKKYPICIELAKQEDFMSK------------------------------- -AEGE------------------------------------------------------- ----------R-------------------------------SEAGDER----------- ------------------------------------------------------------ --------------------------------TTGLGEKLERTDKAEKAEVCTSAEDQRR P----------------------------------------------------------- ---------TA--GG-------------------G------------------------- -----------------------------------DL----------------------- --------------TIYLFGRTGREKEEWFRRFLQASQ---------------------- -----------------------MKSEG-------------------------------R GG--SLS----GICK-------------------------SGE----------------- ----MTSR--------SQ--------------------------G------------SSR GSQEEL--SQP--RYRE--TPASLSSGSAG-G---------------------------- ---MKQKMLLDYSIYMAKYV---------------N-----PQ----------------- ---------------AP--PGSP----PAVD----SPG---------------------- ------------------------------------------------------------ ---------HTPESSPKATKK---L---------P-RS---------------------- ----------SE--EAAE-----PEAWVNAFLGRIFWDFLREKYWADVVSKKIQMKLSKI RLPYVMNELTLTELDMGFSVPKILCASKPSVDHQGLWFDLEVSYTGSFLMTLETKLNLAR LGKE--GEGL--GDHGKEW--PRTYCLADSDEESSSAGSSDEEDPPE------------- --------L-LSDKPNLP----ASEGYVGGHRPSKIMRFVDKIAKSKYFQKATETEFIKK KMEEVSNTPLLLTVEVQECRGTLAVNIPPPPTDRIWYGFRSPPHLELKARPKLGEREVTL VHVTEWIEKKLDQEFQ-------------------------------------------- ------------------------------------------------------------ --------------------------------------------------KIFVMPNMDD IWLPIMHSAMDMRSNA-------------------------------------------- ------------------------------------------------------------ ---------------NL-T--LTNDALKD---P-----EPE------------------- ---------ES-EV-SDV---------- >ENSCVAP00000001955 ---------------------------MM------------------------------- ------------------------------------------------------------ -------------------------------------------SSQG------------- ------------------SS----RKGSGQHADT--P--------------------LRQ --------APGPK-----------------------LQVQRSHSRDTITIHFSALGK-EE EDEE-----------------------E-E--LYRLSVGCEAGAQSQPARTDEQCAAKGL EAKVEKGFESVEEEISAAPLP--------------------------------------- -AASAL------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------LPEQPLDSHP----------------------------- -QTPSFAITANPVSAHSHLSSPP----------------------------PAS------ --------------------------------------------------SSWP------ -----------------------------SD--------------------RP-TQ---- ------------------------------------------------------------ --------------------------------------------------PPLISSAS-- ---------------------------------------------------------SSP CK-------S-------------------AALSS--------------------SKPFL- S---------LVRSLSND-VDSRETAPV----------I------------VPP------ ------H-A-----RHR-HLMKSFVKSLSTDT-SKGEHQEGPLQH--------------- ---PPQH-QQIQPT------HRAPP-----RNMQLFKQFSQPR----------LS-SCPV AVTQA--GGD-SKTAPSSPIMSP-DGR---SF-FKVQEVEARIEDTKRRLSEVMSDPLQL FSKIMGDES---GMGAA--------------------------------------G---- SA----------AHRAKSLSSSASELSGVTAVN-GHTEA---NNN-YSIK-EEGA--EG- E--------------------E--EEETPTEKG--------------------------- ---------------------------------------------------------P-- ----------------------------------------------DSSFFS-------- ------------------------------------------------------------ ----FPSLSLAPALTQASSSTLHRS----------------------------------- --------PSL------------------TLGRCSMSALVARQEDEDFCELYSEDF---- ----------------------------------------------------ELCTDTET PEG--------------------------------------------------------- ----------------------EQSMLQQPHTGSTGLGRELDV----------------- ------------------------------------------------------------ -----------------------------------------------------------E DGRP-------------------------------------------------------- ------------------------------------------------------------ ---------------------------------------------------------E-- ---EEM--------------ENVPVVGLVFLTQLLYCYFVLPVPPCVCSVLHGIAVGFIL ALLVLWLSAP---------------------------------R---------------- -------------C-SS-LVT-----------RTG---------RWR-------KDQR-- ----------------NISQ-----------------LDVKEPGIFKGWMNEIHSYDPEM YHATLTHSIYVRLEGSVLRLSKPNRNISRRAAHNE--PKPDVTYISQKIYDLTDSRIYLM PQSLARKRVWNKKYPICIELAKQEDFMSK------------------------------- -VEGE------------------------------------------------------- ----------R-------------------------------SEAGEER----------- ------------------------------------------------------------ --------------------------------TTGVGEMLERTDKAERPEGCSSAEEQRR P----------------------------------------------------------- ---------TA--GG-------------------G------------------------- -----------------------------------DL----------------------- --------------TIYLFGRTGREKEEWFRRFLQASQ---------------------- -----------------------MKSEG-------------------------------R GS--SLS----SICK-------------------------S------------------- ------------------A--FLSTQSRSGSIQSG-GAPEADSRG------------SSR GSQEEL--SQP--RHRE--TPASLYGGSAG-G---------------------------- ---MKQKMLLDYNVYMAKYV---------------N-----PQ----------------- ---------------AP--PGSP----SAAD----SPA---------------------- ------------------------------------------------------------ ---------QSPESSPKTTKK---L---------P-KS---------------------- ----------TE--EAAE-----PEAWVNAFLGRIFWDFLREKYWADVVSKKIQMKLSKI RLPYVMNELTLTELDMGFSVPKILRASKPSVDHQGLWFDLDISYAGSFLMTLETKLNLAR LGKE--GEGL--GEHGKEWPRPRTYCLADSDEESSSAGSSDEEDPPE------------- --------L-LSDKPNLP----ASEGYVGGYRPSKIMRFVDKIAKSKYFQKATETEFIKK KMEEVSNTPILLTVEVQECRGTLAVNIPPPPTDRIWYGFRSPPHLELKARPKLGEREVTL VHVTEWIEKKLDQEFQ-------------------------------------------- ------------------------------------------------------------ --------------------------------------------------KIFVMPNMDD IWLPIMHSAMDLRSNA-------------------------------------------- ------------------------------------------------------------ ---------------NL-T--VTTDALKD---P-----EPE------------------- ---------ES-EV-SDT---------- >ENSKMAP00000026229 ---------------------------MM------------------------------- ------------------------------------------------------------ -------------------------------------------STQG------------- -----------------SSS----RKGSGQHADTP-P--------------------PRH --------PSGPK-----------------------LQVQRSHSRDTITIHFSALGK-EE EDDD-----------------------E-E--LY-------------------------- ------------------------------------------------------------ ------G-----------------V----------------------------------- --------------------------------------------------------PVGS AAPKSVLDGVEG-------------------PQV-------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -------RATGTDDQYVAK--------------GLEAKEELL------------------ ----------------------------------FESSDVE------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------ASSGAAVLP--------------------------- -------------------------------------------------V---------- SSTTLSLQPSDTHL---------------------------------------------- ------------------------------------------------------------ -HTPSHAMSITSVSAHSHLSSTP----------------------------PTS------ --------------------------------------------------SSWP------ -----------------------------SD--------------------RP-AQ---- ------------------------------------------------------------ --------------------------------------------------LPPTSSSS-- ---------------------------------------------------------SSP CK-------S-------------------GAMST--------------------SQPFL- S---------LVRSLSND-VDSREAAPA----------ATT---------IVPQ------ ------H-A-----RHR-HLMKSFVKSLSTDT-SRPEHQEGPLHH--------------- ---HPQHPQQVQPS------HRTPP-----RNMQLFKQFSQPR----------LS-SCPV AVTQS--GGD-SKTAPSSPIMSP-DGR---SF-FKVQEVEAKIEDTKRRLSEVMSDPLQL FSKIMGDET---GGGAA--------------------------------------G---- SA----------AHRAKLLSSSASELSGVTAVN-GHTEA---NNN-YSIK-EEGA--EG- D--------------------E--DEETPTEKG--------------------------- ---------------------------------------------------------H-- ----------------------------------------------DSNFFS-------- ------------------------------------------------------------ ----FPSLSLAPSFNQTSSSTLHKS----------------------------------- --------PSL------------------TLGRCSMSALTARQEDEDFCELYSEDF---- ----------------------------------------------------EVCTDTET PDG--------------------------------------------------------- ----------------------DRSISQQPHTGSTGLCSELDV----------------- ------------------------------------------------------------ -----------------------------------------------------------E DERL-------------------------------------------------------- ------------------------------------------------------------ ---------------------------------------------------------E-- ---EEV--------------ENVPVTGLVFLTQLVYWYLVLPVPPCVCAVVHGIVAGFML ALLVLWLSSP---------------------------------R---------------- -------------H-SS-SGT-----------RTL---------QRR-------KDQW-- ----------------IFSQ-----------------VDVKEPEIFKGWMNEIHSYDPEM YHATLTHSVYVRLEGSVLRLSKPNRNISRRAAHNE--PKPDVTYISQKIYDLTDSRIYLM PQSLARKRVWNKKYPICIELAKQDDFMSK------------------------------- -AQGE------------------------------------------------------- ----------K-------------------------------SEAGEEK----------- ------------------------------------------------------------ --------------------------------SAGLAEKVERTDKAERSEGSASVEEPKR P----------------------------------------------------------- ---------AT--GR-------------------A------------------------- -----------------------------------DL----------------------- --------------TIYLFGRTGREKEEWFRRFLQASQ---------------------- -----------------------MKSEG-------------------------------R GG--GLS----GICK-------------------------S------------------- ------------------A--FLPSHSRSGSIPSA-GGPEADSR-------------SSR GSQEEL--SQP--RHRE--AAAPLSCGPAG-G---------------------------- ---TKQKMLLDYNIYMAKYV---------------N-----PQ----------------- ---------------AA--PGSP----SGAD----SPE---------------------- ------------------------------------------------------------ ---------HSPESSPKTTKK---L---------R-RS---------------------- ----------SE--ETAE-----PEAWVNAFLGRIFWDFLREKYWANVVSKKIQMKLSKI RLPYVMNELTLTELDMGFSTPKILRASKPWVDHQGLWFDLEVSYTGSFLMTLETKLNLAR LGKE--GEGL--GEHGKEW--PRTYCLADSDEESSSAGSSDEEDPPE------------- --------L-LSDKPSLP----ASEGYVGGHRPSKIMRFVDKIAKSKYFQKATETEFIKK KMEEVANTPLLLTVEVQECRGTLAVNIPPPPTDRIWYGFRSPPHLELKARPKLGEREVTL VHVTEWIEKKLDQEFQ-------------------------------------------- ------------------------------------------------------------ --------------------------------------------------KIFVMPNMDD IWLPIMHSAMDTRSNA-------------------------------------------- ------------------------------------------------------------ ---------------NLAT--VTNDALKE---P-----ELQ------------------- ---------------------------- >ENSPNYP00000023900 ----------------------------M------------------------------- ------------------------------------------------------------ -------------------------------------------SSQG------------- ------------------GS----SRGSGQHAATP-P--------------------PRH --------TPGPK-----------------------LQVQRSHSRDTITIHFSALGK-EE DDEE-----------------------E-E--LF-------------------------- ------------------------------------------------------------ ------G-----------------I----------------------------------- --------------------------------------------------------PAGS VKDKFVLDGTGGLQG--------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -------PASAADDRCVAT--------------GLEAKEELL------------------ ----------------------------------FESAGAD------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------TPSGPAVLP--------------------------- -------------------------------------------------V---------- LSTTLSVQPSDP------------------------------------------------ -----------------------------QP----------------------------- -HTHSPALTINPTSTL---SSNP----------------------------PAS------ --------------------------------------------------SSWP------ -----------------------------SE--------------------RLPVN---- ------------------------------------------------------------ --------------------------------------------------PSPASSSS-- ---------------------------------------------------------SSP CK-------S-------------------AALSS--------------------SKPFL- S---------LVRSLSND-VESRETVPS----------LST---------VAPT------ ------H-A-----RHR-HLMKSFVKSLSTDA-SKADHSEGPLQH--------------- --------QQIQPS------HRPPP-----RNMQLFKQFSQPR----------LS-SSPV IVTQA--GGD-SKTAPSSPIMSP-DGR---SF-FKVQEVEAKIEDTKRRLSEVMSDPLQL FSKIMGDES---GTGSA--------------------------------------G---- SA----------AYRAKSLSSSASELSGVTAVN-GHGEG---GNN-YSIKEEEGA--EG- E--------------------D--EEETPTAKG--------------------------- ---------------------------------------------------------P-- ----------------------------------------------ESGFFS-------- ------------------------------------------------------------ ----FPSL--APALTQASSSALHKS----------------------------------- --------PSL------------------TLGRCSMSALVARQEDEDFCELYSEDF---- ----------------------------------------------------ELCTDTET PDG--------------------------------------------------------- ----------------------DRSGSRQPHTGSTGLCSELD------------------ ------------------------------------------------------------ ----------------------------------------------------------PE DERA-------------------------------------------------------- ------------------------------------------------------------ ---------------------------------------------------------E-- ---EEA--------------ETLPVTGLIILTQLVYWYLVLPVPPCVCSVVHGIIAGFAL ALLVLWLSSP---------------------------------Q---------------- -------------P-SS-SVS-----------RKR---------RRR-------IEQW-- ----------------NVAQ-----------------LDIKEPGIFKGWMNEIHSYDPET YHATLTHSVYVRLEGSVLRLSKPNRNISRRATHNE--PKPDVTYISQKIYDLTDSKIYLM PQSLARKRVWNKKYPICIELAKQDDFMSK------------------------------- -AQGE------------------------------------------------------- ----------R-------------------------------PEAGEEK----------- ------------------------------------------------------------ --------------------------------ST--------------AEGSASAEEPKK P----------------------------------------------------------- ---------TF--GG-------------------G------------------------- -----------------------------------DL----------------------- --------------TIYLFGRTGREKEEWFRRFLLASR---------------------- -----------------------MKSEG-------------------------------R GG--SLP----T------------------------------------------------ ---------------------FLPSHSRSSSFQSV-GGLEADSRS------------SSR GSLEELSQSQS--RHRE--TTAALSCGSTA-G---------------------------- ---LKQKMLLDYNVYMAKYV---------------S-----PQ----------------- ---------------VP--PRSP----TATD----SAR---------------------- ------------------------------------------------------------ ---------NSPD----------------------------------------------- ----------SK--ETAE-----PEAWVNAFLGRIFWDFLGEKYWANVVSKKIQMKLSKI RLPYVMNELTLTELDMGFSIPKILRASKPSVDHQGLWFDLEVSYTGSFLMTLETKMNLAR LGKE--GEGL--GEHGKDWSRPRTYCLADSDEESSSAGSSDEEDPPE------------- --------L-LSDKPVLP----GAEGYVGGHRPSKIMRFVDKIAKSKYFQKATETEFIKK KMEEVSNTPLLLTVEVQECRGTLAVNIPPPPTDRIWYGFRSPPHLELKARPKLGEREVTL VHVTEWIEKKLDQEFQ-------------------------------------------- ------------------------------------------------------------ --------------------------------------------------KIFVMPNMDD VWLPIMHSAMDTRSNA-------------------------------------------- ------------------------------------------------------------ ---------------NLFT--VTNDALKD---P-----EPE------------------- ----------S-DV-SDM---------- >ENSMZEP00005004324 ---------------------------MM------------------------------- ------------------------------------------------------------ -------------------------------------------SSQG------------- ------------------GS----SRGSGQHAATP-P--------------------PRH --------TPGPK-----------------------LQVQRSHSRDTITIHFSALGK-EE DDEE-----------------------E-E--LF-------------------------- ------------------------------------------------------------ ------G-----------------I----------------------------------- --------------------------------------------------------PAGS VKDKSVLDGTGGLQG--------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -------PASAADDRCVAT--------------GLEAKEELL------------------ ----------------------------------FESAGAD------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------TPSGPAVLP--------------------------- -------------------------------------------------V---------- LSTTLSVQPSDP------------------------------------------------ -----------------------------QP----------------------------- -HTHSPALTINPTSTL---SSNP----------------------------PAS------ --------------------------------------------------SSWP------ -----------------------------SE--------------------RLPVN---- ------------------------------------------------------------ --------------------------------------------------PSPASSSS-- ---------------------------------------------------------SSP CK-------S-------------------AALSS--------------------SKPFL- S---------LVRSLSND-VESRETVPS----------LST---------VAPT------ ------H-A-----RHR-HLMKSFVKSLSTDA-SKADHSEGPLQH--------------- --------QQIQPS------HRPPP-----RNMQLFKQFSQPR----------LS-SSPV IVTQA--GGD-SKTAPSSPIMSP-DGR---SF-FKVQEVEAKIEDTKRRLSEVMSDPLQL FSKIMGDES---GTGSA--------------------------------------G---- SA----------AYRAKSLSSSASELSGVTAVN-GHGEG---GNN-YSIKEEEGA--EG- E--------------------D--EEETPTAKG--------------------------- ---------------------------------------------------------P-- ----------------------------------------------ESGFFS-------- ------------------------------------------------------------ ----FPSL--APALTQASSSALHKS----------------------------------- --------PSL------------------TLGRCSMSALVARQEDEDFCELYSEDF---- ----------------------------------------------------ELCTDTET PDG--------------------------------------------------------- ----------------------DRSGSRQPHTGSTGLCSELD------------------ ------------------------------------------------------------ ----------------------------------------------------------PE DERA-------------------------------------------------------- ------------------------------------------------------------ ---------------------------------------------------------E-- ---EEA--------------ETLPVTGLIILTQLVYWYLVLPVPPCVCSVVHGIIAGFAL ALLVLWLSSP---------------------------------Q---------------- -------------P-SS-SVS-----------RKR---------RRR-------IEQW-- ----------------NVAQ-----------------LDIKEPGIFKGWMNEIHSYDPET YHATLTHSVYVRLEGSVLRLSKPNRNISRRATHNE--PKPDVTYISQKIYDLTDSKIYLM PQSLARKRVWNKKYPICIELAKQDDFMSK------------------------------- -AQGE------------------------------------------------------- ----------R-------------------------------PEAGEEK----------- ------------------------------------------------------------ --------------------------------STVQSEKVEKTDKGEKADGSASAEEPKK P----------------------------------------------------------- ---------TF--GG-------------------G------------------------- -----------------------------------DL----------------------- --------------TIYLFGRTGREKEEWFRRFLLASR---------------------- -----------------------MKSEG-------------------------------R GG--SLP----SICK-------------------------N------------------- ------------------A--FLPSHSRSSSFQSV-GGLEADSRS------------SSR GSLEELSQSQS--RHRE--TTAALSCGSTA-G---------------------------- ---LKQKMLLDYNVYMAKYV---------------S-----PQ----------------- ---------------VP--PRSP----TATD----SAR---------------------- ------------------------------------------------------------ ---------NSPDSSPQTTKK---L---------R-RS---------------------- ----------SE--ETAE-----PEAWVNAFLGRIFWDFLGEKYWANVVSKKIQMKLSKI RLPYVMNELTLTELDMGFSIPKILRASKPSVDHQGLWFDLEVSYTGSFLMTLETKMNLAR LGKE--GEGL--GEHGKDWSRPRTYCLADSDEESSSAGSSDEEDPPE------------- --------L-LSDKPVLP----GAEGYVGGHRPSKIMRFVDKIAKSKYFQKATETEFIKK KMEEVSNTPLLLTVEVQECRGTLAVNIPPPPTDRIWYGFRSPPHLELKARPKLGEREVTL VHVTEWIEKKLDQEFQ-------------------------------------------- ------------------------------------------------------------ --------------------------------------------------KIFVMPNMDD VWLPIMHSAMDTRSNA-------------------------------------------- ------------------------------------------------------------ ---------------NLFT--VTNDALKD---P-----EPE------------------- ----------S-DV-SDM---------- >ENSACLP00000041464 ---------------------------MM------------------------------- ------------------------------------------------------------ -------------------------------------------SSQG------------- ------------------GS----SRGSGQHAATP-P--------------------PRH --------TPGPK-----------------------LQVQRSHSRDTITIHFSALGK-EE DDEE-----------------------E-E--LF-------------------------- ------------------------------------------------------------ ------G-----------------I----------------------------------- --------------------------------------------------------PAGS VKDKSVLDGTGGLQG--------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -------PASAADDRCVAT--------------GLEAKEELL------------------ ----------------------------------FESAGAD------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------TPSGPAVLP--------------------------- -------------------------------------------------V---------- LSTTLSVQPSDP------------------------------------------------ -----------------------------QP----------------------------- -HTHSPALTINPTSTL---SSNP----------------------------PAS------ --------------------------------------------------SSWP------ -----------------------------SE--------------------RLPVN---- ------------------------------------------------------------ --------------------------------------------------PSPASSSS-- ---------------------------------------------------------SSP CK-------S-------------------AALSS--------------------SKPFL- S---------LVRSLSND-VESRETVPS----------LST---------VAPT------ ------H-A-----RHR-HLMKSFVKSLSTDA-SKADHSEGPLQH--------------- --------QQIQPS------HRPPP-----RNMQLFKQFSQPR----------LS-SSPV IVTQA--GGD-SKTAPSSPIMSP-DGR---SF-FKVQEVEAKIEDTKRRLSEVMSDPLQL FSKIMGDES---GTGSA--------------------------------------G---- SA----------AYRAKSLSSSASELSGVTAVN-GHGEG---GNN-YSIKEEEGA--EG- E--------------------D--EEETPTAKG--------------------------- ---------------------------------------------------------P-- ----------------------------------------------ESGFFS-------- ------------------------------------------------------------ ----FPSL--APALTQASSSALHKS----------------------------------- --------PSL------------------TLGRCSMSALVARQEDEDFCELYSEDF---- ----------------------------------------------------ELCTDTET PDG--------------------------------------------------------- ----------------------DRSGSRQPHTGSTGLCSELD------------------ ------------------------------------------------------------ ----------------------------------------------------------PE DERA-------------------------------------------------------- ------------------------------------------------------------ ---------------------------------------------------------E-- ---EEA--------------ETLPVTGLIILTQLVYWYLVLPVPPCVCSVVHGIIAGFAL ALLVLWLSSP---------------------------------Q---------------- -------------P-SS-SVS-----------RKR---------RRR-------IEQW-- ----------------NVAQ-----------------LDIKEPGIFKGWMNEIHSYDPET YHATLTHSVYVRLEGSVLRLSKPNRNISRRATHNE--PKPDVTYISQKIYDLTDSKIYLM PQSLARKRVWNKKYPICIELAKQDDFMSK------------------------------- -AQGE------------------------------------------------------- ----------R-------------------------------PEAGEEK----------- ------------------------------------------------------------ --------------------------------STVQSEKVEKTDKGEKAEGSASAEEPKK P----------------------------------------------------------- ---------TF--GG-------------------G------------------------- -----------------------------------DL----------------------- --------------TIYLFGRTGREKEEWFRRFLLASR---------------------- -----------------------MKSEG-------------------------------R GG--SLP----SICK-------------------------N------------------- ------------------A--FLPSHSRSSSFQSV-GGLEADSRS------------SSR GSLEELSQSQS--RHRE--TTAALSCGSTA-G---------------------------- ---LKQKMLLDYNVYMAKYV---------------S-----PQ----------------- ---------------VP--PRSP----TATD----SAR---------------------- ------------------------------------------------------------ ---------NSPDSSPQTTKK---L---------R-RS---------------------- ----------SE--ETAE-----PEAWVNAFLGRIFWDFLGEKYWANVVSKKIQMKLSKI RLPYVMNELTLTELDMGFSIPKILRASKPSVDHQGLWFDLEVSYTGSFLMTLETKMNLAR LGKE--GEGL--GEHGKDWSRPRTYCLADSDEESSSAGSSDEEDPPE------------- --------L-LSDKPVLP----GAEGYVGGHRPSKIMRFVDKIAKSKYFQKATETEFIKK KMEEVSNTPLLLTVEVQECRGTLAVNIPPPPTDRIWYGFRSPPHLELKARPKLGEREVTL VHVTEWIEKKLDQEFQ-------------------------------------------- ------------------------------------------------------------ --------------------------------------------------KIFVMPNMDD VWLPIMHSAMDTRSNA-------------------------------------------- ------------------------------------------------------------ ---------------NLFT--VTNDALKD---P-----EPE------------------- ----------S-DV-SDM---------- >ENSHBUP00000011029 ---------------------------MM------------------------------- ------------------------------------------------------------ -------------------------------------------SSQG------------- ------------------GS----SRGSGQHAATP-P--------------------PRH --------TPGPK-----------------------LQVQRSHSRDTITIHFSALGK-EE DDEE-----------------------E-E--LF-------------------------- ------------------------------------------------------------ ------G-----------------I----------------------------------- --------------------------------------------------------PAGS VKDKSVLDGTGGLQG--------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -------PASAADDRCVAT--------------GLEAKEELL------------------ ----------------------------------FESAGAD------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------TPSGPAVLP--------------------------- -------------------------------------------------V---------- LSTTLSVQPSDP------------------------------------------------ -----------------------------QP----------------------------- -HTHSPALTINPTSTL---SSNP----------------------------PAS------ --------------------------------------------------SSWP------ -----------------------------SE--------------------RLPVN---- ------------------------------------------------------------ --------------------------------------------------PSPASSSS-- ---------------------------------------------------------SSP CK-------S-------------------AALSS--------------------SKPFL- S---------LVRSLSND-VESRETVPS----------LST---------VAPT------ ------H-A-----RHR-HLMKSFVKSLSTDA-SKADHSEGPLQH--------------- --------QQIQPS------HRPPP-----RNMQLFKQFSQPR----------LS-SSPV IVTQA--GGD-SKTAPSSPIMSP-DGR---SF-FKVQEVEAKIEDTKRRLSEVMSDPLQL FSKIMGDES---GTGSA--------------------------------------G---- SA----------AYRAKSLSSSASELSGVTAVN-GHGEG---GNN-YSIKEEEGA--EG- E--------------------D--EEETPTAKG--------------------------- ---------------------------------------------------------P-- ----------------------------------------------ESGFFS-------- ------------------------------------------------------------ ----FPSL--APALTQASSSALHKS----------------------------------- --------PSL------------------TLGRCSMSALVARQEDEDFCELYSEDF---- ----------------------------------------------------ELCTDTET PDG--------------------------------------------------------- ----------------------DRSGSRQPHTGSTGLCSELD------------------ ------------------------------------------------------------ ----------------------------------------------------------PE DERA-------------------------------------------------------- ------------------------------------------------------------ ---------------------------------------------------------E-- ---EEA--------------ETLPVTGLIILTQLVYWYLVLPVPPCVCSVVHGIIAGFAL ALLVLWLSSP---------------------------------Q---------------- -------------P-SS-SVS-----------RKR---------RRR-------IEQW-- ----------------NVAQ-----------------LDIKEPGIFKGWMNEIHSYDPET YHATLTHSVYVRLEGSVLRLSKPNRNISRRATHNE--PKPDVTYISQKIYDLTDSKIYLM PQSLARKRVWNKKYPICIELAKQDDFMSK------------------------------- -AQGE------------------------------------------------------- ----------R-------------------------------PEAGEEK----------- ------------------------------------------------------------ --------------------------------STVQSEKVEKTDKGEKAEGSASAEEPKK P----------------------------------------------------------- ---------TF--GG-------------------G------------------------- -----------------------------------DL----------------------- --------------TIYLFGRTGREKEEWFRRFLLASR---------------------- -----------------------MKSEG-------------------------------R GG--SLP----SICK-------------------------N------------------- ------------------A--FLPSHSRSSSFQSV-GGLEADSRS------------SSR GSLEELSQSQS--RHRE--TTAALSCGSTA-G---------------------------- ---LKQKMLLDYNVYMAKYV---------------S-----PQ----------------- ---------------VP--PRSP----TATD----SAG---------------------- ------------------------------------------------------------ ---------NSPDSSPQTTKK---L---------R-RS---------------------- ----------SE--ETAE-----PEAWVNAFLGRIFWDFLGEKYWANVVSKKIQMKLSKI RLPYVMNELTLTELDMGFSIPKILRASKPSVDHQGLWFDLEVSYTGSFLMTLETKMNLAR LGKE--GEGL--GEHGKDWSRPRTYCLADSDEESSSAGSSDEEDPPE------------- --------L-LSDKPVLP----GAEGYVGGHRPSKIMRFVDKIAKSKYFQKATETEFIKK KMEEVSNTPLLLTVEVQECRGTLAVNIPPPPTDRIWYGFRSPPHLELKARPKLGEREVTL VHVTEWIEKKLDQEFQ-------------------------------------------- ------------------------------------------------------------ --------------------------------------------------KIFVMPNMDD VWLPIMHSAMDTRSNA-------------------------------------------- ------------------------------------------------------------ ---------------NLFT--VTNDALKD---P-----EPE------------------- ----------S-DV-SDM---------- >ENSONIP00000021646 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------S----SRGSGQHADTP-P--------------------PRH --------TPGPK-----------------------LQVQRSHSRDTITIHFSALGK-EE DDEE-----------------------E-E--LF-------------------------- ------------------------------------------------------------ ------G-----------------I----------------------------------- --------------------------------------------------------PAGS ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------ADDRCVAT--------------GLEAKEELL------------------ ----------------------------------FESAGAD------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------TPSGPAVLP--------------------------- -------------------------------------------------V---------- LSTTLSVQPSDP------------------------------------------------ -----------------------------QP----------------------------- -HTHSPALTINPTSTL---SSNP----------------------------PAS------ --------------------------------------------------SSWP------ -----------------------------SE--------------------RLPVN---- ------------------------------------------------------------ --------------------------------------------------PSPASSSS-- ---------------------------------------------------------SSP CK-------S-------------------AALSS--------------------SKPFL- S---------LVRSLSND-VESRETVPS----------LST---------VAPT------ ------H-A-----RHR-HLMKSFVKSLSTDT-SKADHSEGPLQH--------------- --------QQIQPS------HRPPP-----RNMQLFKQFSQPR----------LS-SSPV IVTQA--GGD-SKTAPSSPIMSP-DGR---SF-FKVQEVEAKIEDTKRRLSEVMSDPLQL FSKIMGDES---GTGSA--------------------------------------G---- SA----------AYRAKSLSSSASELSGVTAVN-GHGEG---GNN-YSIKEEEGA--EG- E--------------------D--EEETPTAKG--------------------------- ---------------------------------------------------------P-- ----------------------------------------------ESCFFS-------- ------------------------------------------------------------ ----FPSL--APALTQASSSALHKS----------------------------------- --------PSL------------------TLGRCSMSALVARQEDEDFCELYSEDF---- ----------------------------------------------------ELCTDTET PDG--------------------------------------------------------- ----------------------DRSGSRQPHTGSTGLCSELD------------------ ------------------------------------------------------------ ----------------------------------------------------------PE EERA-------------------------------------------------------- ------------------------------------------------------------ ---------------------------------------------------------E-- ---EEA--------------ETLPVTGLIILTQLVYWYLVLPVPPCVCSVVHGIIAGFAL ALLVLWLSSP---------------------------------Q---------------- -------------P-SS-SAS-----------RKR---------RRR-------IEQW-- ----------------NVAQ-----------------LDIKEPGIFKGWMNEIHSYDPET YHATLTHSVYVRLEGSVLRLSKPNRNISRRATHNE--PKPDVTYISQKIYDLTDSKIYLM PQSLARKRVWNKKYPICIELAKQDDFMSK------------------------------- -AQGE------------------------------------------------------- ----------R-------------------------------PEGGEEK----------- ------------------------------------------------------------ --------------------------------STVQ-------------KGSASAEEPKK P----------------------------------------------------------- ---------TF--GG-------------------G------------------------- -----------------------------------DL----------------------- --------------TIYLFGRTGREKEEWFRRFLLASR---------------------- -----------------------MKSEG-------------------------------R GG--SLP----SICK-------------------------N------------------- ------------------A--FLPSHSRSSSIQSV-GGLEADSRS------------SSR GSLEEL--SQS--RHRE--TTAALSCGSTA-G---------------------------- ---LKQKMLLDYNVYMAKY----------------------------------------- ---------------VP--PRSP----TATD----SAG---------------------- ------------------------------------------------------------ ---------NSPDSSPQTTKK---L---------R-RS---------------------- ----------SE--ETAE-----PEAWVNAFLGRIFWDFLGEKYWANVVSKKIQMKLSKI RLPYVMNELTLTELDMGFSIPKILRASKPSVDHQGLWFDLEVSYTGSFLMTLETKMNLAR LGKE--GEGL--GEHGKDWSRPRTYCLADSDEESSSAGSSDEEDPPE------------- --------L-LSDKPVLP----GGEGYVGGHRPSKIMRFVDKIAKSKYFQKATETEFIKK KMEEVSNTPLLLTVEVQECRGTLAVNIPPPPTDRIWYGFRSPPHLELKARPKLGEREVTL VHITEWIEKKLDQEFQ-------------------------------------------- ------------------------------------------------------------ --------------------------------------------------KIFVMPNMDD VWLPIMHSAMDARSNA-------------------------------------------- ------------------------------------------------------------ ---------------NLFT--VTNDALKD---P-----EPE------------------- ----------S-DV-SD----------- >ENSACIP00000028109 ----------------------------M------------------------------- ------------------------------------------------------------ -------------------------------------------SSQG------------- ------------------SS----SRGSGQHADTP-P--------------------XRH --------TPGPK-----------------------LQVQRSLSRDTITIHFSALGK-EE DDEE-----------------------E-E--LF-------------------------- ------------------------------------------------------------ ------G-----------------I----------------------------------- --------------------------------------------------------PAGS ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------CVTT--------------GLEAKEELL------------------ ----------------------------------FESAGAE------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------TLSEPAVLP--------------------------- -------------------------------------------------V---------- SSTTLSAQPSDP------------------------------------------------ -----------------------------QP----------------------------- -HIPSPAFTINQTPTLSHQSSNP----------------------------PAS------ --------------------------------------------------FSWP------ -----------------------------SE--------------------RPLVN---- ------------------------------------------------------------ --------------------------------------------------PLPTSSSS-- ---------------------------------------------------------SSP CK-------S-------------------AALSS--------------------SKPFL- S---------LVRSLSND-VESRETAPS----------LST---------VAPT------ ------H-A-----RHR-HLMKSFVKSLSTDT-SKAEHSEGPVQH--------------- --------QQIQPS------HRPPP-----RNMQLFKQFSQPR----------LS-SSPI VVTQA--GGD-SKTAPSSPIMSP-DGR---SF-FKVQEVEAKIEDTKRRLSEVMSDPLQL FSKIMGDES---GTGSV--------------------------------------G---- SA----------AHRAKSLSSSASELSGVTAVN-GHGEG--INNN-YSIKEEEGA--EG- E--------------------E--EEETPTAKG--------------------------- ---------------------------------------------------------P-- ----------------------------------------------ESGFFS-------- ------------------------------------------------------------ ----FPSL--APALTQASSSALHKS----------------------------------- --------PSL------------------TLGRCSMSALVARQEDEDFCELYSEDF---- ----------------------------------------------------ELCTDTET PDG--------------------------------------------------------- ----------------------DRSGSRQPHTGSTGLCSELD------------------ ------------------------------------------------------------ ----------------------------------------------------------PE EERV-------------------------------------------------------- ------------------------------------------------------------ ---------------------------------------------------------E-- ---EEA--------------ETIPVAGLIILTQLVYWYLVLPVPPCVCSVVHGIIAGFAL ALLVLWLSSP---------------------------------R---------------- -------------P-SS-SAS-----------RKR---------RRR-------IEQW-- ----------------NVAQ-----------------LDIKEPGIFKGWMNEIHSYDPEM YHATLTHSVYVRLEGSVLRLSKPNRNISRRATHNE--PKPDVTYISQKIYDLTDSKIYLM PQSLARKRVWNKKYPICIELAKQDDFMSK------------------------------- -AQGE------------------------------------------------------- ----------R-------------------------------PEAGEEK----------- ------------------------------------------------------------ --------------------------------ST--------------AEGSASAEEPKK P----------------------------------------------------------- ---------SF--GG-------------------G------------------------- -----------------------------------DL----------------------- --------------TIYLFGRTGREKEEWFRRFLLASR---------------------- -----------------------MKSEG-------------------------------R GA--SLP----GI----------------------------------------------- ------------------S--FLPSHSRSSSIQSA-GGLEADSRS------------SSR GSLEELSQSQS--RHRE--TSAALSCGSTA-G---------------------------- ---LKQKMLLDYNVYMAKYV---------------S-----LQ----------------- ---------------AP--PRSP----AATD----SPG---------------------- ------------------------------------------------------------ ---------NSPESSPQTTKK---L---------R-RS---------------------- ----------SE--ETPE-----PEAWVNAFLGRIFWDFLGEKYWANVVSKKIQMKLSKI RLPYVMNELTLTELDMGFSIPKILRASKPSVDHQGLWFDLEVSYTGSFLMTLETKMNLAR LGKE--GEGL--GEHGKEWSRPRTYCLADSDEESSSAGSSDEEDPPE------------- --------L-LSDKPVLP----GAEGYVGGHRPSKIMRFVDKIAKSKYFQKATETEFIKK KMEEVSNTPLLLTVEVQECRGTLAVNIPPPPTDRIWYGFRSPPHLELKARPKLGEREVTL VHVTEWIEKKLDQEFQ-------------------------------------------- ------------------------------------------------------------ --------------------------------------------------KIFVMPNMDD VWLPIMHSAMDTRSNA-------------------------------------------- ------------------------------------------------------------ ---------------NLFT--VTNDALKD---P-----EPE------------------- ----------S-DV-SDX---------- >ENSAOCP00000008181 ----------------------------M------------------------------- ------------------------------------------------------------ -------------------------------------------SGQG------------- ------------------SS----SRAGGQHADA-----------------------PRH --------APGPK-----------------------LQVQRSLSRDTITIHFSALGK-EE DDEE-----------------------E-E--LY-------------------------- ------------------------------------------------------------ ------G-----------------IG---------------------------------- ----------------------------PAA------------ATSVLDGAGGLRGP--- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------ADDQSVAT--------------GLEAKEELL------------------ ----------------------------------FESVGME------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------LSSGAAVLP--------------------------- -------------------------------------------------V---------- ---------SDP------------------------------------------------ -----------------------------YP----------------------------- -HSPSPAMTIIPT---SHLSSTP----------------------------PTS------ --------------------------------------------------SSWP------ -----------------------------SD--------------------KPLAN---- ------------------------------------------------------------ --------------------------------------------------PPSTSSSS-- ---------------------------------------------------------SSP CK-------S-------------------AALSS--------------------SKPFL- S---------LVRSLSND-VESRETPPA----------LST---------VAPA------ ------H-A-----RHR-HLMKSFVKSLSTDT-SKTEHQEGPLHQYLQ------------ -----QQ----QPS------HRPPP-----RNMQLFKQFSQPR----------LS-SSPV IVTQA--GGETAKTAPSSPIMSP-DGK---SF-FKVQEVEAKIEDTKRRLSEVMSDPLQL FSKIMGDES---GMAAV--------------------------------------G---- ------------THRAKSLSSSASELSGVTAVN-GHAEG---SNK-YSIK-EEGA--EGE E--------------------E--EEETPTGKG--------------------------- ---------------------------------------------------------P-- ----------------------------------------------DSVFFS-------- ------------------------------------------------------------ ----FPPLAPAPAFIQASSSILHKS----------------------------------- --------PSL------------------TLGRCSMSALVARQEDEDFCELYSEDF---- ----------------------------------------------------EICTDTET PDG--------------------------------------------------------- ----------------------DRSGSRQPHTGSTGLCSELDT----------------- ------------------------------------------------------------ ----------------------------------------------------------EE EEKA-------------------------------------------------------- ------------------------------------------------------------ ---------------------------------------------------------E-- ---VEV--------------QTVPVTGLVFLTQLVYWYLVLPVPPWVCAVVHGVVAGFML ALLVLWMSSP---------------------------------R---------------- -------------R-SS-SGT-----------RIG---------RNR-------MEPW-- ----------------NVAQ-----------------LDIKEPGIFKGWMNEIHSYDPEM YHATLTHSVYVRLEGSVLRLSKPNRNISRRAAHNE--PKPDVTYISQKIYDLTDSKIYLM PQSLARKRVWNKKYPICIELAKQEDFMSK------------------------------- -AQGE------------------------------------------------------- ----------R-------------------------------PEAGEDK----------- ------------------------------------------------------------ --------------------------------LPGLGEKIERVDKGEKTEGPALVEEPKR P----------------------------------------------------------- ---------TS--GG-------------------G------------------------- -----------------------------------DL----------------------- --------------TIYLFGRTGREKEEWFRRFLLASR---------------------- -----------------------MKSEG-------------------------------R SG--SLA----GICK-------------------------S------------------- ------------------A--FLPSHSRSSSLQSG-GGLEADSRS------------SSR GSLEEL--PQS--QPRPRDASAAPSCGAAA-G---------------------------- ---MKQKMLLDYNVYMAKYV---------------N-----PQ----------------- ---------------AP--PRSP----TATD----SPG---------------------- ------------------------------------------------------------ ---------HSPDSSPKTTKK---L---------R-RS---------------------- ----------SE--ESAE-----PEAWVNAFLGRIFWDFLGEKYWANVVSKKIQMKLSKI RLPYVMNELTLTELDMGFSIPKILQASKPSVDHQGLWFDLEVSYTGSFLMTLETKMNLAR LGKE--GEGL--GEHGKEW--PRTYCLADSDEESSSAGSSDEEDPPE------------- --------L-LSDKPVLP----GAEGYVGGHRPSKIMRFVDKIAKSKYFQKATETEFIKK KMEEVSNTPLLLTVEVQECRGTLAVNIPPPPTDRIWYGFRSPPHLELKARPKLGEREVTL AHVTEWIEKKLDQEFQ-------------------------------------------- ------------------------------------------------------------ --------------------------------------------------KIFVMPNMDD VWLPIMHSAMDTRSNA-------------------------------------------- ------------------------------------------------------------ ---------------NLIT--VTNDALKD---P-----EPE------------------- ---------DS-EV-SDM---------- >ENSAPEP00000016010 ----------------------------M------------------------------- ------------------------------------------------------------ -------------------------------------------SGQG------------- ------------------SS----SRAGGQHADA-----------------------PRH --------APGPK-----------------------LQVQRSLSRDTITIHFSALGK-EE DDEE-----------------------E-E--LY-------------------------- ------------------------------------------------------------ ------G-----------------IG---------------------------------- ----------------------------PAA------------ATSVLDGAGGLRGP--- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------ADDQSVAT--------------GLEAKEELL------------------ ----------------------------------FESVGME------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------LSSGAAVLP--------------------------- -------------------------------------------------V---------- ---------SDP------------------------------------------------ -----------------------------YP----------------------------- -HSPSPAMTIIPT---SHLSSTP----------------------------PTS------ --------------------------------------------------SSWP------ -----------------------------SD--------------------KPLAN---- ------------------------------------------------------------ --------------------------------------------------PPSTSSSS-- ---------------------------------------------------------SSP CK-------S-------------------AALSS--------------------SKPFL- S---------LVRSLSND-VESRETPPA----------LST---------VAPA------ ------H-A-----RHR-HLMKSFVKSLSTDT-SKTEHQEGPLHQYLQ------------ -----QQ----QPS------HRPPP-----RNMQLFKQFSQPR----------LS-SSPV IVTQA--GGETAKTAPSSPIMSP-DGR---SF-FKVQEVEAKIEDTKRRLSEVMSDPLQL FSKIMGDES---GMAAV--------------------------------------G---- ------------THRAKSLSSSASELSGVTAVN-GHAEG---SNK-YSIK-EEGA--EGE E--------------------E--EEETPTGKG--------------------------- ---------------------------------------------------------P-- ----------------------------------------------DSVFFS-------- ------------------------------------------------------------ ----FPPLAPAPAFIQASSSVLHKS----------------------------------- --------PSL------------------TLGRCSMSALVARQEDEDFCELYSEDF---- ----------------------------------------------------EICTDTET PDG--------------------------------------------------------- ----------------------DRSGSRQPHTGSTGLCSELDT----------------- ------------------------------------------------------------ ----------------------------------------------------------EE EEKA-------------------------------------------------------- ------------------------------------------------------------ ---------------------------------------------------------E-- ---VEV--------------QTVPVTSLVFLTQLVYWYLVLPVPPWVCAVVHGVVAGFML ALLVLWMSSP---------------------------------R---------------- -------------R-SS-SGT-----------RIG---------RNR-------MEPW-- ----------------NVAQ-----------------LDIKEPGIFKGWMNEIHSYDPEM YHATLTHSVYVRLEGSVLRLSKPNRNISRRAAHNE--PKPDVTYISQKIYDLTDSKIYLM PQSLARKRVWNKKYPICIELAKQEDFMSK------------------------------- -AQGE------------------------------------------------------- ----------R-------------------------------PEAGEDK----------- ------------------------------------------------------------ --------------------------------LPGLGEKIERVDKGEKTEGPALAEEPKR P----------------------------------------------------------- ---------TS--GG-------------------G------------------------- -----------------------------------DL----------------------- --------------TIYLFGRTGREKEEWFRRFLLASR---------------------- -----------------------MKSEG-------------------------------R SG--SLA----GICK-------------------------S------------------- ------------------A--FLPSHSRSSSLQSG-GGLEADSRS------------SSR GSLEEL--PQS--QPRPRDASAAPSCGAAA-G---------------------------- ---MKQKMLLDYNVYMAKYV---------------N-----PQ----------------- ---------------AP--PRSP----TATD----SPG---------------------- ------------------------------------------------------------ ---------HSPDSSPKTTKK---L---------R-RS---------------------- ----------SE--ESAE-----PEAWVNAFLGRIFWDFLGEKYWANVVSKKIQMKLSKI RLPYVMNELTLTELDMGFSIPKILQASKPSVDHQGLWFDLEVSYTGSFLMTLETKMNLAR LGKE--GEGL--GEHGKEW--PRTYCLADSDEESSSAGSSDEEDPPE------------- --------L-LSDKPVLP----GAEGYVGGHRPSKIMRFVDKIAKSKYFQKATETEFIKK KMEEVSNTPLLLTVEVQECRGTLAVNIPPPPTDRIWYGFRSPPHLELKARPKLGEREVTL AHVTEWIEKKLDQEFQ-------------------------------------------- ------------------------------------------------------------ --------------------------------------------------KIFVMPNMDD VWLPIMHSAMDTRSNA-------------------------------------------- ------------------------------------------------------------ ---------------NLIT--VTNDALKD---P-----EPE------------------- ---------DS-EV-SDM---------- >ENSAPOP00000007991 ---------------------------MM------------------------------- ------------------------------------------------------------ -------------------------------------------SSQG------------- ------------------SS----SRAGGQHADA-----------------------PRH --------APGPK-----------------------LQVQRSLSRDTITIHFSALGK-EE DDEE-----------------------E-E--LY-------------------------- ------------------------------------------------------------ ------G-----------------VG---------------------------------- ----------------------------PPA------------ATSVLDGAGGMRGS--- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------ADDQSVAT--------------GLEAKEELL------------------ ----------------------------------FESVSEE------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------ILSGAAVLP--------------------------- -------------------------------------------------V---------- ---------SDP------------------------------------------------ -----------------------------HP----------------------------- -HSPSPAMTIIST---AHLSSTP----------------------------PTS------ --------------------------------------------------SSWP------ -----------------------------SD--------------------KPLAN---- ------------------------------------------------------------ --------------------------------------------------PPSTSSSS-- ---------------------------------------------------------SSP CK-------S-------------------AALSS--------------------SKPFL- S---------LVRSLSND-VESQETPPA----------LST---------VTPA------ ------H-A-----RHR-HLMKSFVKSLSTDA-SKAEHQEGPLHQYLQ------------ -----QQ----QPS------HRPPP-----RNMQLFKQFSQPR----------LS-SSPI IVTQA--GGETAKTAPSSPIMSP-DGR---SF-FKVQEVEAKIEDTKRRLSEVMSDPLQL FSKIMGDES---GVAAV--------------------------------------G---- ------------TYRAKSLSSSASELSGVMAVN-GHAEG---SNK-YSIK-EEGA--EGE E--------------------E--EEETPTGKG--------------------------- ---------------------------------------------------------P-- ----------------------------------------------DSVFFS-------- ------------------------------------------------------------ ----FPSLAPAPAFTQASSSVLHKS----------------------------------- --------PSL------------------TLGRCSMSALVARQEDEDFCELYSEDF---- ----------------------------------------------------EICTDTET PDG--------------------------------------------------------- ----------------------DRSGSRQPHTGSTGLCSELDT----------------- ------------------------------------------------------------ ----------------------------------------------------------EE EEKA-------------------------------------------------------- ------------------------------------------------------------ ---------------------------------------------------------E-- ---VEV--------------QTVPVTGLVFLTQLVYWYLVLPVPPWVCAVVHGVVAGFML ALLVLWMSSP---------------------------------R---------------- -------------R-SS-SGT-----------RIG---------RNR-------MEPW-- ----------------NVAQ-----------------LDIKEPGIFKGWMNEIHSYDPEM YHATLTHSVYVRLEGSVLRLSKPNRNISRRAAHNE--PKPDVTYISQKIYDLTDSKIYLM PQSLARKRVWNKKYPICIELAKQEDFMSK------------------------------- -AQGE------------------------------------------------------- ----------R-------------------------------PEAGEDK----------- ------------------------------------------------------------ --------------------------------LPGLSEKLERADKGEKTEGPALVEEPKR P----------------------------------------------------------- ---------TS--GG-------------------G------------------------- -----------------------------------DL----------------------- --------------TIYLFGRTGREKEEWFRRFLLASR---------------------- -----------------------MKSEG-------------------------------R SG--SLA----GICK-------------------------S------------------- ------------------A--FLPSHSRSSSLQSG-GGLEADSRS------------SSR GSLEEL--PQS--QPRPRDTSAAPSCGAAV-G---------------------------- ---MKQKMLLDYNVYMAKYV---------------N-----PQ----------------- ---------------AP--PRSP----TATD----SPG---------------------- ------------------------------------------------------------ ---------HSPDSSPKTTKK---L---------R-RS---------------------- ----------SE--ESAE-----PEAWVNAFLGRIFWDFLGEKYWANVVSKKIQMKLSKI RLPYVMNELTLTELDMGFSIPKILQASKPSVDHQGLWFDLEVSYTGSFLMTLETKMNLAR LGKE--GEGL--GE-GKEW--PRTYCLADSDEESSSAGSSDEEDPPE------------- --------L-LSDKPILP----GAEGYVGGHRPSKIMRFVDKIAKSKYFQKATETEFIKK KMEEVSNTPLLLTVEVQECRGTLAVNIPPPPTDRIWYGFRSPPHLELKARPKLGEREVTL AHVTEWIEKKLDQEFQ-------------------------------------------- ------------------------------------------------------------ --------------------------------------------------KIFVMPNMDD VWLPIMHSAMDTRSNA-------------------------------------------- ------------------------------------------------------------ ---------------NLIT--VTNDALKD---P-----EPE------------------- ---------DS-EV-SDM---------- >ENSSPAP00000023457 ---------------------------MM------------------------------- ------------------------------------------------------------ -------------------------------------------SSQGG------------ ------SSS---------SS----SRAGGQHADTP-P--------------------PRH --------APGPK-----------------------LQVQRSLSRDTITIHFSALGK-EE DDEE-----------------------E-E--LY-------------------------- ------------------------------------------------------------ ------G-----------------V----------------------------------- --------------------------------------------------------PVGS AAATLVLDGAGGLQGA-------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ----------AADDQSVAT--------------GLEAREELL------------------ ----------------------------------FEAVGVE------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------VSSGAAVLP--------------------------- -------------------------------------------------V---------- SSTTLSAQPSDP------------------------------------------------ -----------------------------HP----------------------------- -HTPSPAMTIVSTSTPSHLSSTP----------------------------PAS------ --------------------------------------------------SSWP------ -----------------------------SD--------------------RPSAT---- ------------------------------------------------------------ --------------------------------------------------PPSTSSSS-- ---------------------------------------------------------SSP CK-------S-------------------AALSS--------------------SKPFL- S---------LVRSLSNE-VESREAAPA----------LST---------VAPA------ ------H-A-----RHR-HLMKSFVKSLSTDT-SKAEHQEGPLHPYLQ------------ -----QQ-QQVQPS------HRPPP-----RNMQLFKQFSQPR----------LS-SSPV IVTQA--GGD-SKTAPSSPIMSP-DGR---SF-FKVQEVEAKIEDTKRRLSEVMSDPLQL FSKIMGEES---GV-----------------------------------------GA-AV SV----------THRTKSLSSSASELSAVTAVN-GHAEG---SNK-YSIK-EEGA--EGE E--------------------E--EEETPTGKG--------------------------- ---------------------------------------------------------P-- ----------------------------------------------DSVFFS-------- ------------------------------------------------------------ ----FPSLAPAPALTQASSALLHKS----------------------------------- --------PSL------------------TLGRCSMSALVARQEDEDFCELYSEDF---- ----------------------------------------------------EICTDTET PDG--------------------------------------------------------- ----------------------DRSGSRQPHTGSTGLCSELDT----------------- ------------------------------------------------------------ ----------------------------------------------------------EE EEKA-------------------------------------------------------- ------------------------------------------------------------ ---------------------------------------------------------E-- ---VEV--------------QTVPVTGLICLTQLVYWYLVLPVPPAVCAVVHGVVAGFML ALLVLWLSSP---------------------------------R---------------- -------------R-SS-SGT-------------------------R-------AEPW-- ----------------NVAQ-----------------LDIKEPGIFKGWMNEIHSYDPEM YHATLTHSVYVRLEGSVLRLSKPNRNISRRAAHNE--PKPDVTYISQKIYDLTDSKIYLM PQSLARKRVWNKKYPICIELAKQEDFMSK------------------------------- -AQGD------------------------------------------------------- ----------R-------------------------------PEAGEDK----------- ------------------------------------------------------------ --------------------------------LPGLSEKLERTEKGEKAEGCALVEEPKR P----------------------------------------------------------- ---------AS--GG-------------------G------------------------- -----------------------------------DL----------------------- --------------TIYLFGRTGREKEEWFRRFLLASR---------------------- -----------------------MKSEG-------------------------------R SG--SLA----GICK-------------------------S------------------- ------------------A--FLPSHSRSSSLQSG-GGLEADSRS------------SSR GSLEEL--PQS--QPRPRDASAAPSCCSAA-G---------------------------- ---TKQKMLLDYNVYMAKYV---------------N-----PQ----------------- ---------------AP--PRSP----TATD----SPG---------------------- ------------------------------------------------------------ ---------HSPDSSPKATKK---L---------R-RS---------------------- ----------SE--ETAE-----PEAWVNAFLGRMFWDFLGEKYWANVVSKKIQMKLSKI RLPYVMNELTLTELDMGFSIPKILHASKPSVDHQGLWFDLEVSYTGSFLMTLETKMNLAR LGKE--GEGL--GEHGKEW--PRTYCLADSDEESSSAGSSDEEDPPE------------- --------L-LSDKPVPP----GAEGYVGGHRPSKIMRFVDKIAKSKYFQKATETEFIKK KMEEVSNTPLLLTVEVQECRGTLAVNIPPPPTDRIWYGFRSPPHLELKARPKLGEREVTL GHVTEWIEKKLDQEFQ-------------------------------------------- ------------------------------------------------------------ --------------------------------------------------KIFVMPNMDD VWLPIMHSAMDTRSNA-------------------------------------------- ------------------------------------------------------------ ---------------NLIT--VTNDALKD---P-----EPEP------------------ ---------DP-EV-SDM---------- >ENSSMAP00000024733 ----------------------------M------------------------------- ------------------------------------------------------------ -------------------------------------------SSQG------------- ------------------SG----SRGSDQHADTP-P--------------------PRH --------APGPK-----------------------LQVQRSLSRDTITIHFSALGK-EE DDED-----------------------E-E--LY-------------------------- ------------------------------------------------------------ ------G-----------------V----------------------------------- --------------------------------------------------------PVG- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------SVTA--------------GLEAKEELL------------------ ----------------------------------FESTGEE------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------SFSGAAVLP--------------------------- -------------------------------------------------V---------- SSTTLPVQPSDP------------------------------------------------ -----------------------------HP----------------------------- -HTPSAALTIIPTSTHSHLSSSP----------------------------PTS------ --------------------------------------------------SSWP------ -----------------------------SD--------------------RPTAN---- ------------------------------------------------------------ --------------------------------------------------PPSTSSSS-- ---------------------------------------------------------SSP CK-------S-------------------AALPS--------------------SKPFL- S---------LVRSLSNE-VESRESTPA----------PTA---------AQP------- ------H-A-----RHR-HLMKSFVKSLSTDT-SK------------------------- -----QQ-QQTQPS------HRPPP-----RNMQLFKQFSQPR----------LS-STPV IVTKV--GGD-SKTAPSSPIMSP-DGR---SF-FKVQEVEAKIEDTKRRLSEVMSDPLQL FSKIIGDES---SVGAG--------------------------------------G---- SV----------THRAKFLSSSASELSGGTAMN-GHAEG---NSS-YSIKEEEGT--EG- D--------------------E--EEETPTGKG--------------------------- ---------------------------------------------------------P-- ----------------------------------------------DSVFFS-------- ------------------------------------------------------------ ----FPSLTPAPALSQASSSTLHKS----------------------------------- --------SSL------------------TLGRCSMSALVARQEDEDFCELYSEDF---- ----------------------------------------------------ELCTDTET PDG--------------------------------------------------------- ----------------------DRPGSRQPHTGSAGLCSELDM----------------- ------------------------------------------------------------ ----------------------------------------------------------EE EEKAE------------------------------------------------------- ------------------------------------------------------------ ---------------------------------------------------------E-- ---EEV--------------DTVPVNGLVFLTQFMYWYLVLPVPPCVCAVVHGIAAGFML ALLVLWLSCP---------------------------------R---------------- -------------R-SS-SGM-----------RRG---------RGR-------IGNW-- ----------------NVAQ-----------------LDIKEPGIFKGWMNEIHSYDPEM YHATLTHSVYVRLEGSVLRLSKPNRNISRRAAHNE--PKPDVTYISQKIYDLTDSKIYLM PQSLARKRVWNKKYPICIELAKQEDFMSK------------------------------- -AQGE------------------------------------------------------- ----------K-------------------------------PEGGEDK----------- ------------------------------------------------------------ --------------------------------LTGPGEKLDRTDKCEKAEGSASAEESKI S----------------------------------------------------------- ---------AS--GG-------------------G------------------------- -----------------------------------DL----------------------- --------------TIYLFGRTGREKEEWFRRFLIASR---------------------- -----------------------TKSDG-------------------------------R SG--SLP----GI----------------------------------------------- ------------------S--FLLSHSRSSSTQSG-GGQEADSRS------------SSR GSLEEL--SQS--R------------------AREISSALSG----------------GS AGAMKQKMLLEYNVYMAKYV---------------N-----PQ----------------- ---------------AP--QRSP----AATD----SPG---------------------- ------------------------------------------------------------ ---------NSPESSPETTKK---L---------R-RS---------------------- ----------SE--ETVE-----PEAWVNAFLGRIFWDFLGEKYWADVVSKKIQMKLSKI RLPYVMNELTLTELDMGLSIPKVLRASKPSVDHQGLWFDMEVSYTGSFLMTLETKMNLAR LGKE--GEGL--GEHGKEWPRPRTYCLADSDEESSSAGSSDEEDPQE------------- --------L-LSDRPILP----GGEGFVGGHRPSKIMRFVDKIAKSKYFQKATETEFIKK KMEEVSNTPLLLTVEVQECRGTLAVNIPPPPTDRIWYGFRSPPHLELKARPKLGEREVTL VHVTDWIEKKLDQEFQ-------------------------------------------- ------------------------------------------------------------ --------------------------------------------------KIFVMPNMDD LWLPIMHSAMDTRSNA-------------------------------------------- ------------------------------------------------------------ ---------------NLVT--VTNDALKD---P-----EPD------------------- ---------ES-EV-SDM---------- >ENSLCAP00010027737 ----------------------------M------------------------------- ------------------------------------------------------------ -------------------------------------------SSQG------------- ------------------SS----SRGSGQHADTP-P--------------------PRH --------APGPK-----------------------LQVQRSLSRDTITIHFSALGK-EE DDEE-----------------------E-E--LY-------------------------- ------------------------------------------------------------ ------G-----------------V----------------------------------- --------------------------------------------------------P--- -----------------------------RRAKSGL------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----EGAEASGADDQSVAT--------------GLEAKEELL------------------ ----------------------------------FEPTGME------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------GFSGAAVLP--------------------------- -------------------------------------------------V---------- SSTTLSVQPSEP------------------------------------------------ -----------------------------HP----------------------------- -HIPSAAMTIIPTSTQSHLSSSP----------------------------PAS------ --------------------------------------------------SSWP------ -----------------------------SD--------------------RPTAN---- ------------------------------------------------------------ --------------------------------------------------PPSTSSSS-- ---------------------------------------------------------SSP CK-------S-------------------AALSS--------------------SKPFL- S---------LVRSLSND-VESRESTPA----------PST---------VAPT------ ------H-A-----RHR-HLMKSFVKSLSTDT-SKGEHQEGPLHHYLHQ----------- -----QQ-QQIQPS------HRPPP-----RNMQLFKQFSQPR----------LS-SSPV IVTQA--GGD-SKTAPSSPIMSP-DGR---SF-FKVQEVEAKIEDTKRRLSEVMSDPLQL FSKIMGDES---GVGAG--------------------------------------G---- SS----------AHRTKSLSSSASELCGVTAVN-GHTEG---NNN-YSIKEEEGA--EG- D--------------------E--EDETPTGKG--------------------------- ---------------------------------------------------------P-- ----------------------------------------------DSVFFS-------- ------------------------------------------------------------ ----FPSLAPAPAPAQASSSTFHKS----------------------------------- --------PSL------------------TLGRCSMSALVARQEDEDFCELYSEDF---- ----------------------------------------------------ELCTDTET PDG--------------------------------------------------------- ----------------------DRPGSRQPHTGSTGLCSELDM----------------- ------------------------------------------------------------ ----------------------------------------------------------EE EDKA-------------------------------------------------------- ------------------------------------------------------------ ---------------------------------------------------------D-- ---EEL--------------EAVPVTGLVFLTQLVYWYLLLPVPPSVCAVVHGIAAGFML ALLVLWLSSP---------------------------------R---------------- -------------R-SS-SGT-----------RRG---------KGR-------IGHW-- ----------------NVAQ-----------------LDIKEPGIFKGWMNEIHSYDPEM YHATLTHSVYVRLEGSVLRLSKPNRNISRRATHNE--PKPDITYISQKIYDLTDSKIYLM PQSLARKRVWNKKYPICIELAKQEDFMSK------------------------------- -AQGE------------------------------------------------------- ---------TR-------------------------------PEVGEDK----------- ------------------------------------------------------------ --------------------------------STGPGEKIERMDKGEKAEGSALAEEPKR P----------------------------------------------------------- ---------AS--GG-------------------G------------------------- -----------------------------------DL----------------------- --------------TIYLFGRTGREKEEWFRRFLLASR---------------------- -----------------------MKSEG-------------------------------R GG--GLP----GICK-------------------------S------------------- ------------------A--FLPSHSRSSSTQSG-GGLEADSRS------------SSR GSLEEL--SQS--RQREASSSSAPSCGSAA-G---------------------------- ---MKQKMLLDYNVYMAKYV---------------N-----PQ----------------- ---------------AP--QRSP----TAPD----SPG---------------------- ------------------------------------------------------------ ---------QSPESSPKTTKK---L---------R-RS---------------------- ----------SD--ETVE-----PEAWVNAFLGRIFWDFLGEKYWANVVSKKIQMKLSKI RLPYVMNELTLTELDMGFSIPKILNASKPSVDHQGLWFDLEVSYTGSFLMTLETKMNLAR LGKE--GEGL--GEHGKEWPRPRTYCLADSDEESSSAGSSDEEDPPE------------- --------L-LSDKPVLP----GGESYVGGHRPSKIMRFVDKIAKSKYFQKATETEFIKK KMEEVSNTPLLLTVEVQECRGTLAVNIPPPPTDRIWYGFRSPPHLELKARPKLGEREVTL VHVTDWIEKKLDQEFQ-------------------------------------------- ------------------------------------------------------------ --------------------------------------------------KIFVMPNMDD VWLPIMHSAMDTRSNA-------------------------------------------- ------------------------------------------------------------ ---------------NLVT--VTNDALKD---P-----EPE------------------- ---------ES-EVSSDM---------- >ENSSDUP00000012661 ----------------------------M------------------------------- ------------------------------------------------------------ -------------------------------------------SSQGS------------ ------SSSS------SSSS----SKGSGQHADTP-P--------------------PRH --------APGPK-----------------------LQVQRSLSRDTITIHFSALGK-EE DDEE-----------------------E-E--LY-------------------------- ------------------------------------------------------------ ------G-----------------L----------------------------------- --------------------------------------------------------PVGD ----------------KSVLDGADGLQGV------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -------EASGADDQSVAT--------------GLEAKEELL------------------ ----------------------------------FESAGVE------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------ALSGAAVLP--------------------------- -------------------------------------------------I---------- SSTTLPVQPSDP------------------------------------------------ -----------------------------HP----------------------------- -YTPSAAMTIIPTSAHSHLSSSP----------------------------PAS------ --------------------------------------------------SSWP------ -----------------------------SD--------------------RPTAN---- ------------------------------------------------------------ --------------------------------------------------PPSTSSTS-- ---------------------------------------------------------SSP CK-------S-------------------AALSS--------------------SKPFL- S---------LVRSLSND-VESRESTPA----------PTT---------VAPS------ ------H-A-----RHR-HLMKSFVKSLSTDT-SKAEHQEGPLHHYLHQ----------- -----QQ-QQTQPS------HRPPP-----RNMQLFKQFSQPR----------LS-SSPV IVTQA--GGD-SKTAPSSPIMSP-DGR---SF-FKVQEVEAKIEDTRRRLSEVMSDPLQL FSKIMGDES---GAGAC--------------------------------------G---- SA----------AHRAKSLSSSASELSGVAAVN-GHAEG---NNN-YSIKEEEGP--EG- D--------------------E--EEETPTGKG--------------------------- ---------------------------------------------------------P-- ----------------------------------------------DSVFFS-------- ------------------------------------------------------------ ----FPSMAPAPAFAQASSSTFHKS----------------------------------- --------PSL------------------TLGRCSMSALVARQEDEDFCELYSEDF---- ----------------------------------------------------DLCTDTET PDG--------------------------------------------------------- ----------------------DRPGSRQPHTGSTGVCSELDT----------------- ------------------------------------------------------------ ----------------------------------------------------------EE EEKA-------------------------------------------------------- ------------------------------------------------------------ ---------------------------------------------------------E-- ---EEV--------------DTVPVTALVFLTQLVYWYLVLPVPPSVCAVAHGIAAGFML ALLVLWLSSS---------------------------------R---------------- -------------R-SS-SGT-----------RRG---------RGR-------IGAW-- ----------------NVAQ-----------------LDIKEPGIFKGWMNEIHSYDPEM YHATLTHSVYVRLEGSVLRLSKPNRNISRRAAHNE--PKPDVTYISQKIYDLTDSKIYLM PQSLARKRVWNKKYPICIELAKQEDFMSK------------------------------- -AQGE------------------------------------------------------- ----------R-------------------------------PEATEDK----------- ------------------------------------------------------------ --------------------------------LTGQGEKLERMDKGEKAEGSASTEEPKR P----------------------------------------------------------- ---------AS--GG-------------------G------------------------- -----------------------------------DL----------------------- --------------TIYLFGRTGREKEEWFRRLLLASR---------------------- -----------------------MKSEG-------------------------------R GG--SLS----GICK-------------------------S------------------- ------------------A--FLPSHSRSSSTQSG-GGLEADSRS------------SSR GSMEEL--SQS--RHRDASSSV--SCGSTA-G---------------------------- ---MKQKMLLDYNVYMAKYV---------------N-----PQ----------------- ---------------VQ--PRSP----TATD----SPG---------------------- ------------------------------------------------------------ ---------NSPESSPKTTKK---L---------R-RS---------------------- ----------SE--ETME-----PEAWVNAFLGRIFWDFLGEKYWANVVSKKIQMKLSKI RLPYVMNELTLTELDMGFSIPKILHASKPSVDHQGLWFDLEISYTGSFLMTLETKMNLAR LGKE--GEGL--GEHGKEW--PRTYCLADSDEESSSAGSSDEEDPPE------------- --------L-LSDKPILP----GGEGYVGGHRPSKIMRFVDKIAKSKYFQKATETEFIKK KMEEVSNTPLLLTVEVQECRGTLAVNIPPPPTDRIWYGFRSPPHLELKARPKLGEREVTL GHVTEWIEKKLDQEFQ-------------------------------------------- ------------------------------------------------------------ --------------------------------------------------KIFVMPNMDD IWLPIMHSAMDTRSNA-------------------------------------------- ------------------------------------------------------------ ---------------NLVT--VTNDALKD---P-----EPE------------------- ---------DS-EV-SDM---------- >ENSLCRP00005035429 ----------------------------M------------------------------- ------------------------------------------------------------ -------------------------------------------SSQG------------- ------------------SS----SRGSGQHADTP-P--------------------PRH --------APGPK-----------------------LQVQRSLSRDTITIHFSALGK-EE DDEE-----------------------E-E--LY-------------------------- ------------------------------------------------------------ ------G-----------------L----------------------------------- --------------------------------------------------------SVGS A-------------GAKSGLDGAEGLQGL------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -------EASGADEQSVAT--------------ALEAKEELL------------------ ----------------------------------FECAGLE------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------TVSGAAVLP--------------------------- -------------------------------------------------V---------- SSTTLSVEPSDS------------------------------------------------ -----------------------------HP----------------------------- -HTHSPAMTIIPTSTHPHLSSNP----------------------------PAS------ --------------------------------------------------SSWP------ -----------------------------SD--------------------RPSA----- ------------------------------------------------------------ --------------------------------------------------PPATSSSS-- ---------------------------------------------------------SSP CK-------S-------------------AALPS--------------------SKPFL- S---------LVRSLSND-VESRETTPA----------PTA---------VAPS------ ------H-A-----RHR-HLMKSFVKSLSTDT-SKAEHQEGPLHHYLHHP---------- ---P-HQ-QQQQPS------QRPPP-----RNMQLFKQFSQPR----------LS-SCPV IVTHS--GGD-SKTAPSSPIMSP-DGR---SF-FKVQEVEARIEDTKRRLSEVMSDPLQL FSKIMGDES---GMGAV--------------------------------------G---- SA----------THRAKSLSSSASELSGVAAVN-GHTEG---NNN-YSIKEEEGA--EG- E--------------------E--EEETPTGRG--------------------------- ---------------------------------------------------------P-- ----------------------------------------------DSVFFS-------- ------------------------------------------------------------ ----FPSLTPAPALAQASSTTFPKS----------------------------------- --------PSL------------------TLGRCSMSALVARQEDEDFCELYSEDF---- ----------------------------------------------------ELCTDTET PDG--------------------------------------------------------- ----------------------DRPESRQPHTGSTGLCSELDT----------------- ------------------------------------------------------------ ----------------------------------------------------------EE EEKV-------------------------------------------------------- ------------------------------------------------------------ ---------------------------------------------------------E-- ---EEL--------------ETVPVIGLIFLTQLVYLYVILPVPPYVCAVVHGIVAGFML ALLVLWLSSP---------------------------------RHSSSRS------GK-- --RR-------TE-------------------------------------------NW-- ----------------NVAQ-----------------LDIKEPGIFKGWMNEIHSYDPEM YHATLTHSVYVRLEGSVLRLSKPNRNISRRATHNE--PKPDVTYISQKIYDLTDSKIQLV PQSLARKRVWNKKYPICIELAKQEDFMSK------------------------------- -AQGE------------------------------------------------------- ----------K-------------------------------PEAGEDK----------- ------------------------------------------------------------ --------------------------------LTGLCEKLERTDKCEKVEVSASAEEPKR P----------------------------------------------------------- ---------AS--GG-------------------G------------------------- -----------------------------------DL----------------------- --------------TIYLFGRTGREKEEWFRRFLLASR---------------------- -----------------------MKSEG-------------------------------R SG--SLP----GICK-------------------------S------------------- ------------------A--FLPSHSRSSSTQSA-GGLEADSRS------------SSR GSLEEL--SQL--RNRE--TSSALSCGSTG-G---------------------------- ---IKQKMLLDYNIFMAKYV---------------N-----PQ----------------- ---------------AP--PKSP----TATD----SPG---------------------- ------------------------------------------------------------ ---------HSPESSPKATKK---I---------R-RS---------------------- ----------SE--DTVE-----PEAWLNAFIGRIFWDFLGEKYWANVVSKKIQMKLSKI RLPYVMNELTLTELDMGFSIPKILHASSPSVDHQGLWFDLEVSYTGSFLMTLETKMNLAR LGKE--GEGL--GEHGKEWPRPRTYCLADSDEESSSAGSSDEEDPPE------------- --------L-LSDKAIPP----GGEGYVGGHRPSKIMRFVDKIAKSKYFQKATETEFIKK KMEEVSNTPLVLTVEVQECRGTLAVNIPPPPTDRIWYGFRSPPHLELKARPKLGEREVTL VHVTDWIEKKLDQEFQ-------------------------------------------- ------------------------------------------------------------ --------------------------------------------------KIFVMPNMDD VWLPIMHSAMDTRSNA-------------------------------------------- ------------------------------------------------------------ ---------------NLVT--VTNDALKD---P-----EPE------------------- ---------ES-EV-SDM---------- >ENSCGOP00000009434 ----------------------------M------------------------------- ------------------------------------------------------------ -------------------------------------------SSQG------------- ------------------SS----SWGSGQHADTP-P--------------------PRH --------APGPK-----------------------LQVQRSLSRDTITIHFSALGK-EE DDEE-----------------------E-E--LY-------------------------- ------------------------------------------------------------ ------G-----------------V----------------------------------- --------------------------------------------------------P--- -----------------------------------L---------VSAEAKS-------- ---ELD------------------------------------GAGE------------LQ GLEASGA-----------------DDLSVTAGL-----------------------EANE ELLSES------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------AAVLP--------------------------- -------------------------------------------------V---------- SSTTLSVQPSDP------------------------------------------------ -----------------------------HP----------------------------- -HTPSPAMTIIPTSTQPHLGSTP----------------------------PAS------ --------------------------------------------------SSWP------ -----------------------------SE--------------------RPSAN---- ------------------------------------------------------------ --------------------------------------------------PPSSSSSA-- ---------------------------------------------------------SSP CK-------S-------------------AAMSS--------------------SKPFL- S---------LVRSLSND-VESRETTAA----------PTT---------VAPS------ ------Q-A-----RHR-HLMKSFVKSLSTDT-SKAEHQEGPLHHFLHQP---------- ---PHQQ-QQAQPS------QRPPP-----RNMQLFKQFSQPR----------LC-SSPV VVTQA--GGD-SKTAPSSPIMSP-DGR---SF-FKVQEVEARIEDTKRRLSEVMSDPLQL FSKIMGDES---GVGTV--------------------------------------G---- SG----------AHRTKSLSSSASELSGTTAVN-GHTEG---NNN-YSIKEEEGA----- ---------------------E--EEETLTGKG--------------------------- ---------------------------------------------------------P-- ----------------------------------------------DSVFFS-------- ------------------------------------------------------------ ----FPSLAPAPALTQASSSTFPRS----------------------------------- --------PSL------------------TLGRCSMSALVARQEDEDFCELYSEDF---- ----------------------------------------------------ELCTDTET PDG--------------------------------------------------------- ----------------------DRPSSRQPHTGSTGLCSELDTEE---------EEK--- --E--------------------------------------------------------- ---------------------------------------------------------EEE EEKE-------------------------------------------------------- ------------------------------------------------------------ ---------------------------------------------------------E-- ---EEL--------------DTVPVTGLIFLTQLVYWYIVLPVPPYICAVVHGIVAGFML ALLVLWLSSP---------------------------------R---------------- -------------R-SS-SGM-----------RRG---------RGR-------IEHW-- ----------------NVAQ-----------------LDIKEPGTFKGWMNEIHCYDPEM YHATLTHSVYVRLEGSVLRLSKPNRNISRRATHNE--PKPDVTYISQKIYDLTDSKIYLV PQSLARKRVWNKKYPICIELAKQDDFMSK------------------------------- -AQVE------------------------------------------------------- ----------K-------------------------------PEAGEEK----------- ------------------------------------------------------------ --------------------------------LTGLGEKLERVDKCDKVEVSGSAEEPKR P----------------------------------------------------------- ---------TS--AG-------------------G------------------------- -----------------------------------DQ----------------------- --------------TIYLFGRTGREKEEWFRRFLLASR---------------------- -----------------------MKSEG-------------------------------R GG--SLP----AICK-------------------------S------------------- ------------------A--FLPSHSRSSSTQSC-GGLEADSRS------------SSR GSLDEL--SQS--RHREA--SSALNCGSTG-G---------------------------- ---MKQKMLLDYNVFMAKYV---------------N-----PQ----------------- ---------------AP--QRSP----TATD----SPG---------------------- ------------------------------------------------------------ ---------PSPESSPKTAKK---R---------R-RS---------------------- ----------SE--ETVE-----PEAWVNAFVGRMFWDFLGEKYWANVVSKKIQMKLSKI RLPYVMNELTLTELDMGFSIPKILHASKPSVDHQGLWFDLEVSYTGSFLMTLETKMNLAR LGKE--GEGL--GEQGKEW--PRTYCLADSDEESSSAGSSDEEDPPE------------- --------L-LTDKAILP----GAEGYVGGHRPSKIMRFVDKIAKSKYFQKATETEFIKK KMEEVSNTPLLLTVEVQEFRGTLAVNIPPPPTDRIWYGFRSPPHLELKARPKLGEREVTL VHVTDWIERKLDQEFQ-------------------------------------------- ------------------------------------------------------------ --------------------------------------------------KIFVMPNMDD VWLPIMHSAMDTRSNA-------------------------------------------- ------------------------------------------------------------ ---------------NLVT--VTNDALKD---P-----EPE------------------- ---------ES-EV-SEE---------- >ENSATEP00000035597 ----------------------------M------------------------------- ------------------------------------------------------------ -------------------------------------------SSPG------------- ------------------NS----GRGSGQHADTP-P--------------------PRH --------APGPK-----------------------LQVQRSHSRDTITIHFSALGK-EE DDEE-----------------------E-E--LY-------------------------- ------------------------------------------------------------ ------G-----------------P----------------------------------- --------------------------------------------------------PIGA ----------------KSVLD------GL------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -------EASGADDQSVTT--------------GLEAKEELL------------------ ----------------------------------FESTGVE------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------TSTGAAVLP--------------------------- -------------------------------------------------V---------- LSTTLSVQTIDP------------------------------------------------ -----------------------------QS----------------------------- -HKPSSAMTIISTSTHPHLSSTP----------------------------PAS------ --------------------------------------------------SSWP------ -----------------------------SD--------------------RPLAN---- ------------------------------------------------------------ --------------------------------------------------PPSTSSSC-- ---------------------------------------------------------SSP CK-------S-------------------ATLSS--------------------PKPFL- S---------LVRSLSND-VESRETTPA----------PAT---------VVPS------ ------H-A-----RHR-HLMKSFVKSLSTDT-SKAEHPEGPLHH--------------- -----QR-QQIQSS------HRPPP-----RNMQLFKQFSQPR----------LS-SSPV VVTQA--GGD-SKTAPSSPIMSP-DGR---SF-FKVQEVEAKIEDTKRRLSEVMSDPLQL FSKIMGDES---AVGAL--------------------------------------G---- SA----------T-RSKSLSSSASELSGGTAVN-GHAEG---NNN-YSIKEEEGV--EG- E--------------------D--EEETPTGKA--------------------------- ---------------------------------------------------------P-- ----------------------------------------------DFTFFS-------- ------------------------------------------------------------ ----FPSLAPASSLTQAYSSTVQKS----------------------------------- --------PSL------------------TLGRCSMSALVARQEDEDFCELYSEDF---- ----------------------------------------------------ELCTDTET PDG--------------------------------------------------------- ----------------------DQPGSRKPHTDSTGLCSELDM----------------- ------------------------------------------------------------ ----------------------------------------------------------DE EEKT-------------------------------------------------------- ------------------------------------------------------------ ---------------------------------------------------------E-- ---EEV--------------ETVPVIGLIFLTQLVYCYLVFPVPPCVCAVVHGLVAGFML ALLVLWLSSS---------------------------------R---------------- -------------R-FP-SGR-----------RRK---------RRR-------IDHW-- ----------------NVAQ-----------------LDIKEPGIFKGWMNEIHSYDPEM YHATLTHSVYVRLEGSVLRLSKPNRNISRRATHNE--PKPDVTYISQKIYDLTDSKIFLM PQSLARKRVWNKKYPICIELAKQEDFMSK------------------------------- -AQGD------------------------------------------------------- ----------R-------------------------------PETGEDK----------- ------------------------------------------------------------ --------------------------------STGLGEKPEPTNKAEKTEVSGSTEEPKR P----------------------------------------------------------- ---------AP--GG-------------------G------------------------- -----------------------------------DL----------------------- --------------TIYLFGRTGREKEEWFRRFLLASR---------------------- -----------------------MKSEG-------------------------------R AS--SLP----GICK-------------------------S------------------- ------------------A--FLPSHSRSSSTQSS-GGLEADSRS------------SSR GSLEEL--SLS--RHKE--TSSAFSCGSTG-G---------------------------- ---MKQKMMLDYNVYMAKYV---------------N-----RQ----------------- ---------------AP--LRSP----NATD----SPG---------------------- ------------------------------------------------------------ ---------QSPESSPRATKK---L---------R-RS---------------------- ----------SE--EPEE-----PEAWVNAFLGRIFWDFLGEKYWANVVSKKIQMKLSKI RLPYVMNELTLTELDMGFSIPKILHASKPSVDHQGLWFDLEVSYTGSFLMTLETKLNLAR LGKE--DEGL--GEHGKEWPRPRTYCLADSDEESSSAGSSDEEDPPE------------- --------L-LSDKPILP----GAEGYVGGHRPSKIMRFVDKIAKSKYFQKATETEFIKK KMEEVSNTPLLLTVEVQECRGTLAVNIPPPPTDRIWYGFRSPPHLELKARPKLGEREVTL VHVTDWIEKKLDQEFQ-------------------------------------------- ------------------------------------------------------------ --------------------------------------------------KIFVMPNMDD IWLPIMHSAMDTRSNA-------------------------------------------- ------------------------------------------------------------ ---------------NLVT--VTNDALKD---P-----EPK------------------- ---------ES-EV-SDM---------- >ENSMALP00000025717 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------ETTLNGGC-----------GQHADTP-P--------------------TCH --------IPGPK-----------------------LQVQRSLSRDTITIHFSALGK-EE DDEE-----------------------E-E--LY-------------------------- ------------------------------------------------------------ ------G-----------------V----------------------------------- --------------------------------------------------------PAGA --------------------------------------------------KSGPHGAEGL HGFE-------------------------------------------------------- ------------------------------------------------------------ -----------ADDQSVAT--------------GLEAKEDLL------------------ ----------------------------------FESTGVE------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------TASGAAVFP--------------------------- -------------------------------------------------V---------- SSTTLSVQPSDC------------------------------------------------ -----------------------------HS----------------------------- -HTPSPAMTFIPTSTHSHLSSTP----------------------------PAS------ --------------------------------------------------SLWS------ -----------------------------SD--------------------RPSAN---- ------------------------------------------------------------ --------------------------------------------------PPSTSSSS-- ---------------------------------------------------------SSP CK-------S-------------------AALSS--------------------SKPFL- S---------LVRSLSSD-VESRETT------------LAT---------VTPS------ ------H-T-----RHR-HLMKSFVKSLSTDT-SKAEHQEGPFHHYLHQ----------- -----PQ-QQIQPS------HRSAP-----RNMQLFKQFSQPR----------LS-SSPV VVTQA--GGD-SKTAPSSPVMSP-DGR---SF-FNVQEVEAKIEDTKRRLSEVMSDPLQL FSKIMGDES---GVGAI--------------------------------------G---- SA----------THRSKSLSSSASELSGVTAVN-GHTEG---NNN-YSIKEEEGA--EG- E--------------------E--DEETPTGKG--------------------------- ---------------------------------------------------------P-- ----------------------------------------------DSVFIS-------- ------------------------------------------------------------ ----LPSLAPAPAFTQASSSTLHKS----------------------------------- --------PSL------------------TLGRCSMSALVARQEDEDFCELYSEDF---- ----------------------------------------------------ELCTDTET PDG--------------------------------------------------------- ----------------------DRFGSRRPHTGSTGLCSELDM----------------- ------------------------------------------------------------ ----------------------------------------------------------EE EEKP-------------------------------------------------------- ------------------------------------------------------------ ---------------------------------------------------------E-- ---EEV--------------EAVPVTGLIFLTQMVYWYSVLPVPPSVCAVVHGIVAGFFL ALLVLWLSSP---------------------------------Q---------------- -------------H-SA-SGT-----------RGG---------RRR-------IEHW-- ----------------NVAQ-----------------LDIKEPGIFKGWMNEIHSYDPEM YHATLTHSVYVRLEGSVLRLSKPNRNISRRATHNE--PKPDVTYISQKIYDLTDSKIYLM PKSLARKRVWNKKYPICIELAKQEDFMSK------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------RMDKGEKAEVSGSAEEPKR P----------------------------------------------------------- ---------AS--GG-------------------G------------------------- -----------------------------------DL----------------------- --------------TIYLFGRTGREKEEWFQRFLVASR---------------------- -----------------------MKSEG-------------------------------R GS--NL----------------------------------H------------------- ------------------A--FLPTHTRSGSTQSS-GGLEADSRS------------SSR GSLEEL--PQS--RHRE--TPSAFSFGSTG-G---------------------------- ---MKQKMLLDYSVYMAKYV---------------N-----PQ----------------- ---------------AP--LRSP----AATD----SPG---------------------- ------------------------------------------------------------ ---------NSPESSPKTTKK---L---------H-RS---------------------- ----------SE--ETVE-----PEAWVNAFLGRIFWDFLGEKYWANVVSKKIQMKLSKI RLPYVMNELTLTELDMGFSIPKVLHASRPSVDHQGLWFDLEVSYTGSFLMTLETKMNLAR LGKE--GEGL--GEHGKEWPRPRTYCLADSDEESSSAGSSDEEDPPE------------- --------L-LSDKHVLP----GGEGYVGGHRPSKIMRFVDKIAKSKYFQKATETEFIKK KMEEVSNTPLLLTVEVQECRGTLAVNIPPPPTDRIWYGFRNPPHLELKARPKLGEREVTL VHVTDWIEKKLNQEFQ-------------------------------------------- ------------------------------------------------------------ --------------------------------------------------KIFVMPNMDD VWLPIMHSAMDTRSSA-------------------------------------------- ------------------------------------------------------------ ---------------SLVT--VKNDGLKD---P-----EPE------------------- ---------DS-EV-SDK---------- >ENSLBEP00000034364 ----------------------------M------------------------------- ------------------------------------------------------------ -------------------------------------------STQG------------- ----------------SSSS----SRGSGQHADTT-P--------------------PRQ --------APGPK-----------------------LQVQRSLSRDTITIHFSALGK-EE DDED-----------------------E-E--LY-------------------------- ------------------------------------------------------------ ------G-----------------V----------------------------------- --------------------------------------------------------SLGS -------------DGAKPGLDGAGGLRGL------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -------EASGADEQSVAS--------------ALEAKEELL------------------ ----------------------------------FEAAGGD------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------TSSGAAVLP--------------------------- -------------------------------------------------V---------- LSTTLSVQSSD------------------------------------------------- ------------------------------P----------------------------- -HMPSPAMTITPSSTHSHLSSNP----------------------------PAS------ --------------------------------------------------SSWP------ -----------------------------SD--------------------RPSAN---- ------------------------------------------------------------ --------------------------------------------------PPCTNSGS-- ---------------------------------------------------------SSP CK-------S-------------------AALPS--------------------SKPFL- S---------LVRSLSND-VETRESTPA----------PAA---------NAPP------ ------H-T-----RHR-HLMKSFVKSLSTDQ-SKAEHQDVPLHHYHNQP---------- ---PHQP-HQAQPS------QRAPP-----RNMQLFKQFSQPR----------LS-SCPV VVHQA--GGD-SKTAPSSPIMSP-DGR---SF-FKVQEVEARIEDTKRRLSEVMSDPLQL FSKIMGDES---GMGAG--------------------------------------G---- SA----------AHRAKFLSSSASELSGGAAVN-GHAES---NNN-YSIKEEEGA--EG- E--------------------EEDEEETPTGKG--------------------------- ---------------------------------------------------------P-- ----------------------------------------------DSVFFS-------- ------------------------------------------------------------ ----FPSLAPAPVLNQSSSSTFPKS----------------------------------- --------PSL------------------TLGRCSMSALVARQEDEDFCELYSEDF---- ----------------------------------------------------DICTDTET PDA--------------------------------------------------------- ----------------------DRPGSRQPRAGSTGLCSELDT----------------- ------------------------------------------------------------ ----------------------------------------------------------EE EEEE-------------------------------------------------------- ------------------------------------------------------------ ---------------------------------------------------------E-- ---EEVDED----------LETVPVTGLILLTQLVYWYLLLPVPPYVCAVVHGIVAGFMI LLLILWTSSS---------------------------------R------------GSPL VTRR-------W--------------------------------RRR-------IEQW-- ----------------NVAQ-----------------LDIKEPGIFKGWMNEIHSYDPEM YHATLTHSVYVRLEGSVLRLSKPNRNISRRATHNE--PKPDVTYISQKIYDLTDSKIQLV PQSLARKRVWNKKYPICIELAKQEDFMSK------------------------------- -AQGE------------------------------------------------------- ----------K-------------------------------PEAAEEK----------- ------------------------------------------------------------ --------------------------------SSGVGEKLERSDKCEKVEGAGSAEEPKR P----------------------------------------------------------- ---------TS--GG-------------------G------------------------- -----------------------------------DL----------------------- --------------TIYLFGRTGREKEEWFRRFLVASR---------------------- -----------------------MKSEG-------------------------------R SG--SLP----GICK-------------------------S------------------- ------------------A--FLPSHSRSSSTQSAGGGLEADSRS------------SSR GSLEEL--PQP--R---------LSCSSAG-G---------------------------- ---MRQKMLLDYNVYMAKYV---------------N-----PQ----------------- ---------------AP--QRSP----TAPD----SPG---------------------- ------------------------------------------------------------ ---------NSPESSPKTTKK---L---------R-RS---------------------- ----------SE--EPAE-----PEAWVNAFLGRIFWDFLGEKYWANVVSKKIQMKLSKI RLPYVMNELTLTELDMGFSTPKILHASKPSVDHQGLWFDLEVSYTGSFLMTLETKMNLAR LGKE--GEGL--GEHGKEWPRPRTYCLADSDEESSSAGSSDEEDPPE------------- --------L-LSDKAIPL----GGEGYMGGHRPSKIMRFVDKIAKSKYFQKATETEFIKK KMEEVSNTPLLLTVEVQECRGTLAVNIPPPPTDRIWYGFRSPPHLELKARPKLGEREVTL VHVTDWIEKKLDQEFQ-------------------------------------------- ------------------------------------------------------------ --------------------------------------------------KIFVMPNMDD IWLPIMHSAMDTRSNA-------------------------------------------- ------------------------------------------------------------ ---------------NLLT--VTDDTLKD---P-----DPE------------------- ---------DS-EV-SDM---------- >ENSPRNP00000020310 ----------------------------M------------------------------- ------------------------------------------------------------ -------------------------------------------SSQG------------- ------------------SS----NKGGGQHADTP-P--------------------PRH --------TPGPK-----------------------LQVQRSQSRDTITIHFSALGK-EE DDED-----------------------E-E--LY-------------------------- ------------------------------------------------------------ ------G-----------------V----------------------------------- --------------------------------------------------------PVGA TKAKSVLDGTDGIQG--------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -------PASGPDDQCVTT--------------GLEAREELL------------------ ----------------------------------FESSGVE------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------TSSAAAVLP--------------------------- -------------------------------------------------V---------- SSTTLSAKLSD------------------------------------------------- ------------------------------P----------------------------- -HTPSSAVTIIPTSSYSHLSSTP----------------------------PAS------ --------------------------------------------------SSWP------ -----------------------------SD--------------------RPSVI---- ------------------------------------------------------------ --------------------------------------------------ASPTSSST-- ---------------------------------------------------------SSP CK-------S-------------------SGLSS--------------------SKPFL- S---------LVRSLSND-VESRETTPA----------LPA---------VAPP------ ------H-A-----RHR-HLMKSFVKSLSTDT-SKAEHHE-------------------- --------QQIQPS------HRPPP-----RNMQLFKQFSQPR----------LS-SSTV IVTQT--GGD-SKTAPSSPIMSP-DGR---SF-FKVQEVEAKIEDTKRRLSEVMSDPLQL FSKIMGDES---GVGAA--------------------------------------G---- SA----------AHRTKSLSSSASELSGVTTVN-GHPES---NNN-YSIKEEEGA--DG- E--------------------E--EEETPTGKV--------------------------- ---------------------------------------------------------P-- ----------------------------------------------DSVFFS-------- ------------------------------------------------------------ ----FPSL--TPAFTQTSSSALHKS----------------------------------- --------PSL------------------TLGRCSMSALVARQEDEDFCELYSEDF---- ----------------------------------------------------EICTDTET PDG--------------------------------------------------------- ----------------------DHSGSRQPYTGSTGLCSELDT----------------- ------------------------------------------------------------ -----------------------------------------------------------E EEKA-------------------------------------------------------- ------------------------------------------------------------ ---------------------------------------------------------E-- ---EEV--------------ESVPLTGLVFFTQLVYWYLVLPVPPWLCSVVHGIVAGFML ALLVLWLSSP---------------------------------R---------------- -------------R-SS-SGT-----------RMG---------KRR-------IEPW-- ----------------NVAQ-----------------LDIKEPGIIKGWMNEIYSYDPET YHATLTHSVYVRLEGSVLRLSKPNRNISRRATHNE--PKPDVTYISQKIYDLTDSKIYLM PQSLARKRVWNKKYPICIELAKQDDFLSK------------------------------- -AQGE------------------------------------------------------- ----------K-------------------------------TEAGDEK----------- ------------------------------------------------------------ --------------------------------LTGLGEKLERTDKADKAEGSASAEEPKK T----------------------------------------------------------- ---------TS--GG-------------------G------------------------- -----------------------------------DL----------------------- --------------TIYLFGRTGREKEEWFRRFLLASR---------------------- -----------------------MKSEG-------------------------------R GS--SLP----GI----------------------------------------------- ------------------S--FLPSHSRSSSTQSA-GILEADSRS------------SSR GSLEEL--SQS--RHRE--PSVAPPCGSTG-G---------------------------- ---VKQKMLLDYYVYMAKYV---------------N-----PQ----------------- ---------------AS--SRSP----TATD----SPG---------------------- ------------------------------------------------------------ ---------QSPESSPKTTKK---V------------S---------------------- ----------SE--EAAE-----PEAWVNAFLGRIFWDFLGEKYWANVVSKKIQMKLSKI RLPYVMNELTLTELDMGFSIPKILRASKPSVDHQGLWFDLEVTYTGSFLMTLETKMNLAR LGKE--GEGL--GEHGKEWPRPRTYCLADSDEESSSAGSSDEEDPPE------------- --------L-LSDKPILP----GGEGYVGGHRPSKIMRFVDKIAKSKYFQKATETEFIKK KMEEVSNTPLLLTVEVQECRGTLAVNIPPPPTDRIWYGFRSPPHLELKARPKLGEREVTL GHITEWIEKKLDQEFQ-------------------------------------------- ------------------------------------------------------------ --------------------------------------------------KIFVMPNMDD VWLPIMHSAMDMRSNA-------------------------------------------- ------------------------------------------------------------ ---------------NLIT--VTNDALKD---S----EEPE------------------- ---------ES-EA-SDM---------- >ENSMAMP00000034891 ----------------------------M------------------------------- ------------------------------------------------------------ -------------------------------------------SSQG------------- ------------------SS----GRGSGQNADTP-P--------------------PRH --------APGPK-----------------------LQVQRSLSRDTITIHFSALGK-EE DDEE-----------------------E-E--LY-------------------------- ------------------------------------------------------------ ------G-----------------V----------------------------------- --------------------------------------------------------PAGD ----------------KSELDVARVLQGQ------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -------EVSGVDDQSITT--------------GLEAKEELL------------------ ----------------------------------FESTGLE------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------ASTGPAVLP--------------------------- -------------------------------------------------V---------- SSAILSVQPSDP------------------------------------------------ -----------------------------HS----------------------------- -QTPSTGMTF--TTTHSHLNSSP----------------------------PSS------ --------------------------------------------------SSWS------ -----------------------------TD--------------------KPAA----- ------------------------------------------------------------ --------------------------------------------------PPSISAGS-- ---------------------------------------------------------SSP CR-------S-------------------VALSS--------------------SKPFL- S---------LVRSLSNE-VASRESAPA----------PAT---------VAPP------ ------P-A-----RHR-HLMKSFVKSLSTDT-SKAEHQEGPSHH-LNQ----------- -----QQ-QHTQSS------HRPPP-----RNMQLFKQFSQPR----------LS-SSPI IVTQA--GGD-SKTAPSSPIMSP-DGR---SF-FKVQEVEAKIEDTKRRLSEVMSDPLQL FSKIMGDES---TVGAI--------------------------------------G---- SG----------THRAKSLSASASELSGVTAVN-GHAEG----SS-YSIKEEDGA--EG- E--------------------E--DEETPTGKA--------------------------- ---------------------------------------------------------P-- ----------------------------------------------DSVFFP-------- ------------------------------------------------------------ ----FPSVAPGPAPSQASSSSFHKS----------------------------------- --------PSL------------------TLGRCSMSALVARQEDEDFCELYSEDF---- ----------------------------------------------------ELCTDTET PDG--------------------------------------------------------- ----------------------DRSGSRRPHVSTTGLCSELDT----------------- ------------------------------------------------------------ ----------------------------------------------------------EE EEKLE------------------------------------------------------- ------------------------------------------------------------ ---------------------------------------------------------E-- ---EEE--------------KTVPVVGLIFLTQLVYWYLVVPVPPSVCAVVHGIVAGFML ALLVLWLSSP---------------------------------R---------------- -------------R-SA-SGT-----------RGG---------TRR-------IEHW-- ----------------NVPQ-----------------LDIKEPGIFKGWMNEIYSYDPEM YHATLTHSVYVRLEGSVLRLSKPNRNISRRATHNE--PKPEVTYISQKIYDLADSKIYLM PQSLARKRVWNKKYPICIELAKQEDFMSK------------------------------- -AQGE------------------------------------------------------- ----------R-------------------------------PEPGEEK----------- ------------------------------------------------------------ --------------------------------LPGLAEK-ERTDKGDKPDVSGSAEETKR P----------------------------------------------------------- ---------FS--GG-------------------G------------------------- -----------------------------------DL----------------------- --------------TIYLFGRTGREKEEWFRRFLLASR---------------------- -----------------------MKSDG-------------------------------R GG--NLP----GICK-------------------------S------------------- ------------------A--FLPSHSRSSSTQSG-GGLEADSRS------------SSR GSLEEL--SQS--RHRE--TFSALSCGSTV-G---------------------------- ---MKQKMLLDYNVYMAKYV---------------N-----PH----------------- ---------------AL--QRSP----TAID----SPG---------------------- ------------------------------------------------------------ ---------HSPESSPKTTRK---L---------R-RS---------------------- ----------SE--ETME-----PEAWVNAFLGRIFWDFLGEKYWANVVSKKIQMKLSKI RLPYVMNELTLTELDMGFSIPKILHASKPSVDHQGLWFDLEVSYMGSFLMTLETKMNLAR LGKE--GEGL--GEHGKEWPRPRTYCLADSDEESSSAGSSDEEDPPE------------- --------L-LSDKPILP----GGEGYVGGHRPSKIMRFVDKIAKSKYFQKATETEFIKK KMEEVSNTPLLLTVEVQECRGTLAVNIPPPPTDRIWYGFRSPPHLELKARPKLGEREVTL VHVTDWIEKKLDQEFQ-------------------------------------------- ------------------------------------------------------------ --------------------------------------------------KIFVMPNMDD IWLPIMHSAMDTRSNA-------------------------------------------- ------------------------------------------------------------ ---------------NYVT--MTNDALKD---P-----EPE------------------- ---------ES-EV-TDVKTAG--QSIN >ENSCSEP00000022727 ----------------------------M------------------------------- ------------------------------------------------------------ -------------------------------------------SSQG------------- ------------------SS----SRGGGQHADTP-P--------------------SRQ --------PSGPK-----------------------LQVQRSLSRDTITIHFSALGK-DE DDDD-----------------------E-E--LY-------------------------- ------------------------------------------------------------ ------G-----------------T----------------------------------- --------------------------------------------------------PV-- ------------------------------------------------------------ ---------------------------------------------EARPGLGGTEDIAVQ ------------------------------------------------------------ -------ETSGVEDQSVAT--------------GLEAAEELL------------------ ----------------------------------FESTEVN------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------SSSEPPVLP--------------------------- -------------------------------------------------I---------- SSTTLSLQPS-------------------------------------------------- -----------------SRV---------------------------------------- ---PSAAVTINPTSTHSHLKSSP----------------------------PTS------ --------------------------------------------------SSWP------ -----------------------------SE--------------------LPTAN---- ------------------------------------------------------------ --------------------------------------------------PLSTSSNS-- ---------------------------------------------------------SSP GK-------S-------------------AGLSS--------------------SKPFL- S---------LVRSLSND-IESRESAPG----------PTA---------ATSS------ ------H-A-----RHR-HLMKSFVKSLSTDT-SKAEHQEGPLHHYLHQ----------- -----QP-QQTQPS------HRPPP-----RNMQLLKQFSQPR----------LS-SSPM VVTQT--GGD-SKTAPSSPIMSP-DGR---SF-FKVQEVEAKIEDTKRRLSEVMSDPLQL FSKIIGDES---SVGAS--------------------------------------G---- GS----------TQRARFLSSSASELSGAAAVN-GHVDG---NSN-YSIKEEEGM--EG- E--------------------D--DEDTPTVKG--------------------------- ---------------------------------------------------------S-- ----------------------------------------------DSVFFS-------- ------------------------------------------------------------ ----FPSLSSAPTITQASTSTFPRS----------------------------------- --------PSL------------------TLGRCSMSALVARQEDEDFCELYAEDF---- ----------------------------------------------------ELCTDTET PEA--------------------------------------------------------- ----------------------DKPKSQQLHTGST---------------------RLSS EHD--------------------------------------------------------- ---------------------------------------------------------LEE DEKE-------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -------GDEE--------GDSVPITGLIFLTQLVYWYLVLPVPPCACAVVHGIAAGFML ALLILWLSSP---------------------------------R---------------- -------------R----SGT-----------RRG---------RRK-------FGYL-- ----------------NVAQ-----------------LDIKEPGIYKGWMNEINSYDPEM YHATLTHSVYVRLEGSVLRLSKPNKNISRRASHNE--PKPDVTFISQKIYDLTDSKIYLM PQSLARKRVWNKKYPICIELAKQDDFMSK------------------------------- -AQGE------------------------------------------------------- ----------R-------------------------------PESGEDK----------- ------------------------------------------------------------ --------------------------------LTGQTEKSERTDKGEKAEGPASTEEPKR P----------------------------------------------------------- ---------SC--GG-------------------G------------------------- -----------------------------------DL----------------------- --------------TIYLFGRTGREKEEWFRRFLVASR---------------------- -----------------------MKMDG-------------------------------R GG--SLS----GFCK-------------------------S------------------- ------------------A--FLLSHSRSGSSQSG-GALEGDSRS------------SSR GSLEEL--SQL--RHRE--TS--LSCGSSG-G---------------------------- ---IKQKILLDYDVYMAKYV---------------NQPGAQ------------------- ---------------------SP----DVAD----SPE---------------------- ------------------------------------------------------------ ---------NSPESSPKAVKK---V---------R-RT---------------------- ----------SE--SMVE-----PEAWVNAFLGRIFWDFLGEKYWASLVSKKIQMKLSKI RLPYFMNELTLTELDMGFSIPKILHASQPSVDHQGLWFDLEVSYTGSFLMTLETKMNLAR LGKE--GEGL--GEHGKEWPRPRTYCLADSDEESSSAGSSDEEDSQE------------- --------L-LSDKPVVA----GGEGYVGGHRPSKIMRFVDKIAKSKYFQKATETEFIKK KMEEVSNTPLLLTVEVQECRGTLAVNIPPPPTDRIWYGFRSPPHLELKARPKLGEREVTL GHVTEWIEKKLEQEFQ-------------------------------------------- ------------------------------------------------------------ --------------------------------------------------KIFVMPNMDD VWLPIMHSAMDLRSNA-------------------------------------------- ------------------------------------------------------------ ---------------NLVT--VTNDALKD---P-----EPE------------------- ---------ES-EV-SDM---------- >ENSOMEP00000028533 ---------------------------MM------------------------------- ------------------------------------------------------------ -------------------------------------------SSQG------------- -----------------SSS----SKGSGQHADTR-P--------------------LRH --------APGPK-----------------------LQVQRSRSRDTITIHFSALGK-EE EDEE-----------------------Y-D--LY-------------------------- ------------------------------------------------------------ ------S-----------------I----------------------------------- --------------------------------------------------------EVGP AA---------------------------------------------------------- ------------------------------------------------------------ ------AAPVDDGSLGRQGGAAGVDEV--------------------------------- ---------------CVTT--------------GLEAKEEML------------------ ----------------------------------FESAKVE------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------TSLGAPVLP--------------------------- -------------------------------------------------V---------- SS---------------------------------------------------ISSSVQL QDPYLHTLSSTTAVI--------------------------------------------- -----------PISTHSHLSSAP----------------------------PAS------ --------------------------------------------------SSWP------ -----------------------------TD--------------------RP-TH---- ------------------------------------------------------------ --------------------------------------------------PPPTSSSS-- ---------------------------------------------------------SSP CR-------S-------------------TALSS--------------------SKPFL- S---------LVRSLSND-VESREAP------------VST---------AVPP------ ------Q-T-----RHR-QLMKSFVRSLSTDI-SKAEHQEGSPHH--------------- ----------QVPS------HRAPP-----RNMQLFKQFSQPR----------LS-SSPV IATQA--GGD-SKTAPSSPIMSP-DGR---SF-FKVQEVEAKIEDTKRRLSEVMSDPLQL FSKIMGDES---GVGVA--------------------------------------G---- S-----------AHRAKSLSTSASELSGATAVN-GHTDA---NSN-YSIK-EEGG--EG- E--------------------E--EEETPTGKG--------------------------- ---------------------------------------------------------P-- ----------------------------------------------DSVLFS-------- ------------------------------------------------------------ ----FPSLSLSP--ASAPPPNICKS----------------------------------- --------PSL------------------TMGRCSMSALVARQEDEDFCELYSEDF---- ----------------------------------------------------DVCTDTET PDG--------------------------------------------------------- ----------------------DRSISRQPHTGSTGLCSELDA----------------- ------------------------------------------------------------ -----------------------------------------------------------D EERE-------------------------------------------------------- ------------------------------------------------------------ ---------------------------------------------------------E-- ---EEVDC----------------VTGLIFLTQMIYLYLILPVPPCVCSVLHGIVAGFVL ALLVLWLSSP---------------------------------Q---------------- -------------H-SS-SGT-----------SIR---------RRR-------MERW-- ----------------NFAQ-----------------LDISEPGIFKGWMNEIYSYDPEM YHATLTHSVYVRLEGSVLRLSKPNRNISRRATHNE--PKPDVTYISQKIFDLTDSKISLM PQSLARKRVWNKKYPICIELAKQDDFMSK------------------------------- -AQEE------------------------------------------------------- ----------R-------------------------------PDAAEDR----------- ------------------------------------------------------------ --------------------------------LAGQG---ERADLTDRPEGSASTEEQKR P----------------------------------------------------------- ---------TSGGGG-------------------G------------------------- -----------------------------------DL----------------------- --------------TIYLFGRTGREKEEWFRRFLLASR---------------------- -----------------------VKSEG-------------------------------R GG--GLA----GVSK-------------------------S------------------- ------------------A--FLPAHSRSGSFQSG-GGLEADSRS------------SSR GSHEEL---------------SSLPCGSTA-G---------------------------- ---SKQKILLDYNVYMAKYV---------------N-----PQ----------------- ---------------AP--PRSP----AAED----SPG---------------------- ------------------------------------------------------------ ---------QSPESSPKTTKK---L---------Q-RS---------------------- ----------SE--ETDE-----SELWVNAFLGRIFWDFLREKYWADVVSKKIQMKLSKI RLPYVMNELTLTELDMGFSIPKILRASKPSVDHQGLWFDLEISYRGSFLMTLETKLNLAR LGKE--GEGL--GEHGKEW--SRTYCLADSDEESSSAGSSDEEDPPE------------- --------L-LSDKSTQP----GAEGYVGGHRPSKIMRLVDKIAKSKYFQKATETEFIKK KMEEVSNTPLLLTVEVQECRGTLAVNIPPPPTDRIWYGFRSPPHLELKARPKLGEREVTL GHVTEWIEKKLDQEFQ-------------------------------------------- ------------------------------------------------------------ --------------------------------------------------KIFVMPNMDD IWLPIMHSAMDTRSNA-------------------------------------------- ------------------------------------------------------------ ---------------NLMT--VTNDALKD---T-----ETE------------------- ---------ES-DI-PDV---------- >ENSORLP00020017465 ---------------------------MM------------------------------- ------------------------------------------------------------ -------------------------------------------SSQG------------- -----------------SSG----SKGSGQHPDTP-P--------------------LRH --------APGPR-----------------------LQVQRSRSRDTITIHFSALGK-EE EDEE-----------------------D-E--LY-------------------------- ------------------------------------------------------------ ------G-----------------I----------------------------------- --------------------------------------------------------EVGP AA---------------------------------------------------------- ------------------------------------------------------------ ------TASVDDESGGRQGGAAGVDEL--------------------------------- ---------------CVTT--------------GLEAKEEML------------------ ----------------------------------FESAKVE------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------TSSGAAVLP--------------------------- -------------------------------------------------V---------- SS---------------------------------------------------ITSSVQL PDPYLQTLFSTTAVI--------------------------------------------- -----------PISTHSHLSSTP----------------------------PAS------ --------------------------------------------------SSWP------ -----------------------------TD--------------------RP-AH---- ------------------------------------------------------------ --------------------------------------------------PPPTSSSS-- ---------------------------------------------------------SSP CR-------S-------------------TALSS--------------------SKPFL- S---------LVRSLSND-VESRETP------------VST---------AVPP------ ------H-T-----RPR-QLMKSFVRSLSTDI-SKAEHQEGSPHHY-------------- --------PQQIPS------HRAPP-----RNMQLFKQFSQPR----------LS-SAPV IATQA--GGD-SKTAPSSPIMSP-DGR---SF-FKVQEVEAKIEDTKRRLSEVMSDPLQL FSKIMGDES---GVGFT--------------------------------------G---- S-----------AHRAKSLSTSASELSGANAVN-GHTDA---NSN-YSIK-EEGG--EG- E--------------------E--EEKTPTGKG--------------------------- ---------------------------------------------------------P-- ----------------------------------------------DSVLFS-------- ------------------------------------------------------------ ----FPSLSLSPALAQAPSPALCRS----------------------------------- --------PSI------------------TMGRCSMSALVARQEDDDFCELYSEDF---- ----------------------------------------------------DVCTDTET PDG--------------------------------------------------------- ----------------------DRSVSRQPHTGSTGLCSELDA----------------- ------------------------------------------------------------ ----------------------------------------------------------GE EEGE-------------------------------------------------------- ------------------------------------------------------------ ---------------------------------------------------------E-- ---EEVDC----------------VTGLIFLTQMIYLYLILPVPPCVCSVLHGIVTGFVL ALLVLWLSSP---------------------------------Q---------------- -------------P-SS-SGT-----------RIR---------RQR-------MERL-- ----------------NFAQ-----------------LDISEPEIFKGWMNEIYSYDPEM YHATLTHSVYVRLEGSVLRLSKPNRNISRRATHNE--PKPDVTYISQKIFDLTDSKISLM PQSLARKRVWNKKYPICIELAKQDDFMSK------------------------------- -AQEE------------------------------------------------------- ----------R-------------------------------CEAAEDR----------- ------------------------------------------------------------ --------------------------------LAGQG---ERTDHTDRPEGSASTEEQKR P----------------------------------------------------------- ---------SS--GG-------------------G------------------------- -----------------------------------DL----------------------- --------------TIYLFGRTGREKEEWFRRFLLASR---------------------- -----------------------VKLEG-------------------------------R GG--GLA----GVGK-------------------------S------------------- ------------------A--FLPAHSCSGSFQAG-GGLEAD-----------------R GSHEEL---------------SSLPCGPAG-G---------------------------- ---SKQKMQLDYNVYMAKYV---------------N-----PQ----------------- ---------------AP--PRSP----FPDD----SPG---------------------- ------------------------------------------------------------ ---------QSPESSPQTTKK---L---------Q-RS---------------------- ----------LE--ETDE-----SELWVNAFLGRIFWDFLRENYWADVVSKKIQMKLSKI RLPYVMNELTLTELDMGFSIPKILRASKPSVDHQGLWFDLEISYRGSFLMTLETKLNLAR LGKE--GEGL--GEHGKEWPRSRTYCLADSDEESSSAGSSDEEDPPE------------- --------V-LSDKSTQP----GAEGYVGGHRPSKIMRLVDKIAKSKYFQKATETEFIKK KMEEVSNTPLLLTVEVQECRGTLAVNIPPPPTDRIWYGFRSPPHLELKARPKLGEREVTL GHVTEWIEKKLDQEFQ-------------------------------------------- ------------------------------------------------------------ --------------------------------------------------KIFVMPNMDD LWLPIMHSAMDTRSNA-------------------------------------------- ------------------------------------------------------------ ---------------NLMT--VINDAMKD---T-----EPE------------------- ---------ES-DI-PDV---------- >ENSORLP00015026412 ---------------------------MM------------------------------- ------------------------------------------------------------ -------------------------------------------SSQG------------- -----------------SSG----SKGSGQHPDTP-P--------------------LRH --------APGPR-----------------------LQVQRSRSRDTITIHFSALGK-EE EDEE-----------------------D-E--LY-------------------------- ------------------------------------------------------------ ------G-----------------I----------------------------------- --------------------------------------------------------EVGP AA---------------------------------------------------------- ------------------------------------------------------------ ------TASVDDESGGRQGGAAGVDEL--------------------------------- ---------------CVAT--------------GLEAKEEML------------------ ----------------------------------FESAKVE------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------TSSGAAVLP--------------------------- -------------------------------------------------V---------- SS---------------------------------------------------ITSSVQL PDPYLQTLSSTTAVI--------------------------------------------- -----------PISTHSHLSSTP----------------------------PAS------ --------------------------------------------------SSWP------ -----------------------------TD--------------------RP-AH---- ------------------------------------------------------------ --------------------------------------------------PPPTSSSS-- ---------------------------------------------------------SSP CR-------S-------------------TALSS--------------------SKPFL- S---------LVRSLSND-VESRETP------------VST---------AVPP------ ------H-T-----RPR-QLMKSFVRSLSTDI-SKAEHQEGSPHHY-------------- --------PQQIPS------HRAPP-----RNMQLFKQFSQPR----------LS-STPV IATQA--GGD-SKTAPSSPIMSP-DGR---SF-FKVQEVEAKIEDTKRRLSEVMSDPLQL FSKIMGDES---GVGFT--------------------------------------G---- S-----------AHRAKSLSTSASELSGANAVN-GHTDA---NSN-YSIK-EEGG--EG- E--------------------E--EEKTPTGKG--------------------------- ---------------------------------------------------------P-- ----------------------------------------------DSVLFS-------- ------------------------------------------------------------ ----FPSLSLSPALAQAPSPALCRS----------------------------------- --------PSI------------------TMGRCSMSALVARQEDDDFCELYSEDF---- ----------------------------------------------------DVCTDTET PDG--------------------------------------------------------- ----------------------DRSVSRQPHTGSTGLCSELDA----------------- ------------------------------------------------------------ ----------------------------------------------------------GE EEGE-------------------------------------------------------- ------------------------------------------------------------ ---------------------------------------------------------E-- ---EEVDF----------------VTGLIFLTQMIYLYLILPVPPCVCSVLHGIVAGFVL ALLVLWLSSP---------------------------------Q---------------- -------------P-SS-SGT-----------RIR---------RQR-------MERL-- ----------------NFAQ-----------------LDISEPEIFKGWMNEIYSYDPEM YHATLTHSVYVRLEGSVLRLSKPNRNISRRATHNE--PKPDVTYISQKIFDLTDSKISLM PQSLARKRVWNKKYPICIELAKQDDFMSK------------------------------- -AQEE------------------------------------------------------- ----------R-------------------------------CEAAEDR----------- ------------------------------------------------------------ --------------------------------LAGQG---ERTDHTDRPEGSASTEEQKR P----------------------------------------------------------- ---------SS--GG-------------------G------------------------- -----------------------------------DL----------------------- --------------TIYLFGRTGREKEEWFRRFLLASR---------------------- -----------------------VKLEG-------------------------------R GG--GLA----GVGK-------------------------S------------------- ------------------A--FLPAHSCSGSFQAG-GGLEAD-----------------R GSHEEL---------------SSLPCGPTG-G---------------------------- ---SKQKMQLDYNVYMAKYV---------------N-----PQ----------------- ---------------AP--PRSP----FADD----SPG---------------------- ------------------------------------------------------------ ---------QSPESSPQTTKK---L---------Q-RS---------------------- ----------SE--ETDE-----SELWVNAFLGRIFWDFLRENYWADVVSKKIQMKLSKI RLPYVMNELTLTELDMGFSIPKILRASKPSVDHQGLWFDLEISYRGSFLMTLETKLNLAR LGKE--GEGL--GEHGKEWPRSRTYCLADSDEESSSAGSSDEEDPPE------------- --------V-LSDKSTQP----GAEGYVGGHRPSKIMRLVDKIAKSKYFQKATETEFIKK KMEEVSNTPLLLTVEVQECRGTLAVNIPPPPTDRIWYGFRSPPHLELKARPKLGEREVTL GHVTEWIEKKLDQEFQ-------------------------------------------- ------------------------------------------------------------ --------------------------------------------------KIFVMPNMDD LWLPIMHSAMDTRSNA-------------------------------------------- ------------------------------------------------------------ ---------------NLMT--VINDAMKD---T-----EAE------------------- ---------ES-DI-PDV---------- >ENSORLP00000011181 GICHSTQLLSCLSPPSLLFSSSAFSCV--------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------LQVQRSRSRDTITIHFSALGK-EE EDEE-----------------------D-E--LY-------------------------- ------------------------------------------------------------ ------G-----------------I----------------------------------- --------------------------------------------------------EVGP A----------------------------------------------------------- ------------------------------------------------------------ --------------------------L--------------------------------- ---------------CVTT--------------GLEAKEEML------------------ ----------------------------------FESAKVE------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------TSSGAAVLP--------------------------- -------------------------------------------------V---------- SS---------------------------------------------------ITSSVQL PDPYLQTLSSTTAVI--------------------------------------------- -----------PISTHSHLSSTP----------------------------PAS------ --------------------------------------------------SSWP------ -----------------------------TD--------------------RP-AH---- ------------------------------------------------------------ --------------------------------------------------PPPTSSSS-- ---------------------------------------------------------SSP CR-------S-------------------TALSS--------------------SKPFL- S---------LVRSLSND-VESRETP------------VST---------AVPP------ ------H-T-----RPR-QLMKSFVRSLSTDI-SKAEHQEGSPHHY-------------- --------PQQIPS------HRAPP-----RNMQLFKQFSQPR----------LS-STPV IATQA--GGD-SKTAPSSPIMSP-DGR---SF-FKVQEVEAKIEDTKRRLSEVMSDPLQL FSKIMGDES---GVGFT--------------------------------------G---- S-----------AHRAKSLSTSASELSGANAVN-GHTDA---NSN-YSIK-EEG------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------ALAQAPSPALCRS----------------------------------- --------PSI------------------TMGRCSMSALVARQEDDDFCELYSEDF---- ----------------------------------------------------DVCTDTET PDG--------------------------------------------------------- ----------------------DRSVSRQPHTGSTGLCSELDA----------------- ------------------------------------------------------------ ----------------------------------------------------------GE EEGE-------------------------------------------------------- ------------------------------------------------------------ ---------------------------------------------------------E-- ---EEVDC----------------VTGLIFLTQMIYLYLILPVPPCVCSVLHGIVAGFVL ALLVLWLSSP---------------------------------Q---------------- -------------P-SS-SGT-----------RIR---------RQR-------MVRL-- ----------------NFAQ-----------------LEISEPEIFKGWMNEIYSYDPEM YHATLTHSVYVRLEGSVLRLSKPNRNISRRATHNE--PKPDVTYISQKIFDLTDSKISLM PQSLARKRVWNKKYPICIELAKQDDFMSK------------------------------- -AQEE------------------------------------------------------- ----------R-------------------------------CEAAEDR----------- ------------------------------------------------------------ --------------------------------LAGQG---ERTDHTDRPEGSASTEEQKR P----------------------------------------------------------- ---------SS--GG-------------------G------------------------- -----------------------------------DL----------------------- --------------TIYLFGRTGREKEEWFRRFLLASR---------------------- -----------------------VKLEG-------------------------------R GG--GL------------------------------------------------------ ---------------------------------AG-GGLEAD-----------------R GSHEEL---------------SSLPCGPAG-G---------------------------- ---SKQKMQLDYNVYMAKYV---------------N-----PQ----------------- ---------------AP--PRSP----FADD----SPGGL-------------------- ----------------------------------------------------------NI MKSRTFFPP--------------------------------------------------- -----------E--ETDE-----SELWVNAFLGRIFWDFLRENYWADVVSKKIQMKLSKI RLPYVMNELTLTELDMGFSIPKILRASKPSVDHQGLWFDLEISYRGSFLMTLETKLNLAR LGKE--GEGL--GEHGKEW--SRTYCLADSDEESSSAGSSDEEDPPE------------- --------V-LSDKSTH---------YVGGHRPSKIMRLVDKIAKSKYFQKATETEFIKK KMEEVSNTPLLLTVEVQECRGTLAVNIPPPPTDRIWYGFRSPPHLELKARPKLGEREVTL GHVTEWIEKKLDQEFQ-------------------------------------------- ------------------------------------------------------------ --------------------------------------------------KIFVMPNMDD LWLPIMHSAMDTRSNA-------------------------------------------- ------------------------------------------------------------ ---------------NLMT--VINDAMKD---T-----EPE------------------- ---------ES-DI-PDV---------- >ENSGWIP00000003483 ---------------------------MM------------------------------- ------------------------------------------------------------ -------------------------------------------SSQG------------- -----------------SGS----SKGSAQHGDTL-L--------------------PRH --------APGPK-----------------------LQVQRSLSRDTITIHFSALGK-DE DDDD-----------------------E-E--LY-------------------------- ------------------------------------------------------------ ------G-----------------V----------------------------------- --------------------------------------------------------PA-- ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------MSAAATFVSDRTEGVEGVALKADGR--- ---------------SVTT--------------GLEAKEELL------------------ ----------------------------------FESAVVEA------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------D--------PSTAGAAVLS--------------------------- -------------------------------------------------V---------- SSTTLSVQPSD-----RQQTSSPAMSIASMSSP---------TN---------------- ------------------------------------------------------------ ------------------LSSTP----------------------------PAS------ --------------------------------------------------SSWP------ -----------------------------SE--------------------RPPAI---- ------------------------------------------------------------ --------------------------------------------------PPSTNSNS-- ---------------------------------------------------------SSP CK-------S-------------------ATLPS--------------------SKPFL- S---------LVRSLSND-IESRETSSM----------LST---------GAPP------ ------H-A-----RHR-HLMKSFVKSLSTDT-AKTEQPEGPLHHF-------------- -----QQ-QQPQSS------HRHPP-----RNMQLFKQFSQPR----------LS-SSPV IVTQV--GGD-SKTAPSSPIMSP-DGR---SF-FKVQEVEAKIEDTKRRLSEVMSDPLQL FSKIMGDES---NLGAV--------------------------------------G---- NA----------SHRTKSLSSSASELSGGTAVN-GHAE----NSN-YSIKEEDAT--EG- D--------------------E---EETSTMKA--------------------------- ---------------------------------------------------------S-- ----------------------------------------------DSVF---------- ------------------------------------------------------------ ------SLAPATGITQASSSALHKS----------------------------------- --------PSL------------------TLGRCSMSALVARQEDEEFCELYSEDF---- ----------------------------------------------------EVCTDTET PDG--------------------------------------------------------- ----------------------D----RHPQTGSTGLCSEIDT----------------- ------------------------------------------------------------ -----------------------------------------------------------E EDRL-------------------------------------------------------- ------------------------------------------------------------ ---------------------------------------------------------E-- ---EEV--------------EAVPVTGLVFLAQIVFLYLLLPVPPSVCSVVHGIVTGFML ALLVLWMSSS---------------------------------Q---------------- ---RSLLGSNFW--------------------------------RRR-------VELW-- ----------------NMGH-----------------LDIKEPGIFKGWMNEIYSYDPET YHATLTHSVYVRLEGSVLRLSKPNRNISRRATHNE--PKPDVTFISQKIYDLTDSKIYLM PQSLARKRVWNKKYPICIELAKQEDFMSK------------------------------- -AQGEMGEEKFAGPVEKQEQ-------------------TEKCEKTDSSAP--------- ---------G-------------------------------------------------- ------------------------------------------------------------ -------------------------------------------------------EEPKR P----------------------------------------------------------- ---------MC--GG-------------------G------------------------- -----------------------------------DL----------------------- --------------TIYLFGRTGREKEEWFRRFLLSSQ---------------------- -----------------------MKSEG-------------------------------K AGVLSLP----FICK-------------------------S------------------- ------------------A--FLPSQSRSGSIQSG-GGVEADSRS------------SSR GSLEELSQSQS--RYRE--SSAALACGSTG-A---------------------------- ---IKQKMLLDYNVYMAKYV---------------N-----PQ----------------- ---------------AP--PRSP----TATD----SPE---------------------- ------------------------------------------------------------ ---------LSPVSSPKATKK---L---------N-RR---------------------- ----------SE--DTDE-----PEAWVNAFLGRIFWDFLGEKYWADVVSKKIQMKLSKI RLPYVMNELTLTELDMGFSIPKILQASKPSVDHQGLWFDLEISYTGSFLMTLETKMNLAR LGKE--GEGL--GEHGKEWPRPRTYCLADSDEESSSAGSSDEEDAPD------------- --------L-LSDKPALP----GGEGYVGGHRPSKIMRFVDKIAKSKYFQKATETEFIKK KMEEVANTPLLLTVEVQECRGTLAVNIPPPPTDRIWYGFRNPPHLELKARPKLGEREVTL GHVTEWIEKKLDQEFQ-------------------------------------------- ------------------------------------------------------------ --------------------------------------------------KIFVMPNMDD IWLPIMHSAMDTRSNA-------------------------------------------- ------------------------------------------------------------ ---------------NLIT--VTNDELKD---P-----EPE------------------- ---------ES-GL-CDM---------- >ENSHCOP00000012972 ----------------------------M------------------------------- ------------------------------------------------------------ -------------------------------------------SSDS------------- ---------------SGGSS----SRGGRQHAEAT-P--------------------SRH --------TPGPK-----------------------LQVQRSLSRDTITIHFSALCK-EE DDEE-----------------------E-E--LY-------------------------- ------------------------------------------------------------ ------G-----------------L----------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -----DAGGRPGRDDAGSLEVHRSKKGLVFESETTTVTPHANAA---------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----SPAMTIFPSFTSPQLSSTP----------------------------PSS------ --------------------------------------------------SSWP------ -----------------------------SE--------------------RPLAS---- ------------------------------------------------------------ --------------------------------------------------LPATSSSS-- ---------------------------------------------------------SSP CK-------S-------------------TGLSS--------------------SRPFL- S---------LVRSLSND-VEARDPIPP----------TTT---------VAPS------ ------H-A-----RHR-HLMKSFVKSLSTDS-SKAEHQE-------------------- ------------PS------QRPPP-----RNMQLFKQFSQPR----------LS-STPI IATQV--GGD-SKTAPSSPTMSP-DGR---SF-FKVQEVEAKIEDTRRRLSEVMSDPLQL FSKIMGEES---SAGGV--------------------------------------G---- SG----------PHRARLLSSSASELSGMTAVN-GHSEG----YN-YSIKEEEG------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------APTLNQTSASTLARS----------------------------------- --------PSL------------------NLGRCSMSALVARQEDEDFCELYSEDF---- ----------------------------------------------------DLCTDTET PDG--------------------------------------------------------- ----------------------DRPGSRGLHTGSTGLCSEVDI----------------- ------------------------------------------------------------ -----------------------------------------------------------E EEEE-------------------------------------------------------- ------------------------------------------------------------ ---------------------------------------------------------E-- ---EEV--------------ETVPWIGLVYMTQLVYWYLVLPLPQYACAVAHGIFAGFTL AILVLWLSAP---------------------------------R---------------- -------------R-SY-LGT-----------RKQ---------RHR-------REPW-- ----------------NVSQ-----------------FEIKEPGLFKGWMNEIHNYDPEM YHATLTHSVYVRLEGSVLRLSKPNRNISRRATHNE--PKPDVTYISQKIYDLTDSKIYLM PQSLARKRVWNKKYPVCIELAKQDDFMSK------------------------------- -AHGE-----------KAEEDKLTTQGEKTEQVEYKVEKTE------------------- ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------ASADEQKK P----------------------------------------------------------- ---------AP--GG-------------------G------------------------- -----------------------------------DL----------------------- --------------TIYLFGRTGREKEEWFRRFLLASQ---------------------- -----------------------MKSDG-------------------------------R GG--SLP----------------------------------------------------- -------KSGQCSSSAS------------------------------------------- ------------------------SCGPAT-G---------------------------- ---VRQKMLLDYNLYMAKYV---------------H-----PQ----------------- ---------------PA--PTSP----AAAQ----SPG---------------------- ------------------------------------------------------------ ---------HSPDRSP-------------------------------------------- ----------SD--EAAE-----PEAWVNAFLGRIFWDFLGEKYWANVVSKKIQMKLSKI RLPYVMNELTLTELDMGVSIPKILGASRPSMDHQGLWFDLEVSYTGSFLMTLETKMNLAR LGKE--GEGL--SEHGKEW--PRTYCLADSDEESSSAGSSDEEDPP-------------- ------------------------DSYVGGHRPSKIMRFVDKIAKSKYFQKATETEFIKK KMEEVANTPLLLTVEVQECRGTLAVNIPPPPTDRIWYGFRSPPHLELKARPKLGEREVTL VHVTDWIEKKLDQEFQ-------------------------------------------- ------------------------------------------------------------ --------------------------------------------------KIFVMPNMDD LWLPIMHSAMDTRSNA-------------------------------------------- ------------------------------------------------------------ ---------------SSIS--ESNDALRG---P-----EPE------------------- ---------ES-EV-SYI---------- >ENSTRUP00000041772 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------NTSLGYKHACIDEFFYPRLPTKLLQVQRSLSRDTITIHFSALGK-EE DDEE-----------------------E-E--LY-------------------------- ------------------------------------------------------------ ------------------------------------------------------------ --------------------------EGP------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------GADDHLLTT--------------GLEAKEDLV------------------ ----------------------------------FES----------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------PGLQASSRDAV----------LTLEESEFP HHAPSSAMTINSPSDHSHLSSNP----------------------------STS------ --------------------------------------------------SSWP------ -----------------------------TD--------------------RPLAN---- ------------------------------------------------------------ --------------------------------------------------PPAPGFSS-- ---------------------------------------------------------SSP GK-------A-------------------GPLPS--------------------SKPFL- S---------LVRSLSND-MESRETAQG----------PAT---------AATL------ ------H-V-----RHR-HLMKSFVKSLSTDT-SK------------------------- -----Q--QQVVPP-----SQRSSP-----RNMQLFKQFSQPR----------LT-SCPV TVARA--GGD-SKTAPSSPIMSP-DGR---SF-FKVQEVEARIEDTRRRLSEVMSDPLQL FSKIMGDES---VTGAV--------------------------------------G---- GA----------THRAKLLSSSASELTGGTAVN-GHADG---NSS-YCIKEEEWA--EG- D--------------------E--EEEAAKGKG--------------------------- ---------------------------------------------------------S-- ----------------------------------------------DSAFFS-------- ------------------------------------------------------------ ----FPSLAPAQVLAQASSSSLPRS----------------------------------- --------PSL------------------TLGRCSMSALVARQEDEDFCELYSEDF---- ----------------------------------------------------DLCTSTGS PDG--------------------------------------------------------- ----------------------DFSASQQPYAGDPEICGELDP----------------- ------------------------------------------------------------ -----------------------------------------------------------D EEEK-------------------------------------------------------- ------------------------------------------------------------ ---------------------------------------------------------A-- ---AES--------------ESAPVTGLIFLTQMVYLYLAFPVPPYACAVVHGMVAGFAL ALLVLWLSSP---------------------------------R---------------- -------------R-SS-PGA-----------RKG---------KRR-------TEQW-- ----------------NVAQ-----------------LDIKEPGIFKGWMNEIHSYDPEM YHATLTHSVYVRLEGSVLRLSKPHRNISRRAAHNE--PKPDVTFTSQKIYDLTDSKIQLL PQSLARKRVWNKKYPICIELARQEDFMSK------------------------------- -AQGE------------------------------------------------------- ----------K-------------------------------AESGEDK----------- ------------------------------------------------------------ --------------------------------PTGTVEKLERSDS-EKFEMSGWTEEPRR R----------------------------------------------------------- ---------TS--GG-------------------G------------------------- -----------------------------------DL----------------------- --------------TIYLFGRTGREKEEWFRRFLLASR---------------------- -----------------------LKTDG-------------------------------R GG--T------------------------------------------------------- ---------------------FLPSHTRAGSTHSC-GGLEADSRS------------SSR GSLEEL--SQA--R-------------SAG-A---------------------------- ---AKQKMLLDYSVYMAKYV---------------Q-----HQ----------------- ---------------AP--IRSP----TASE----SPG---------------------- ------------------------------------------------------------ ---------QSPDSSPKATKKVHQM---------G-RS---------------------- ----------SE--ETVE-----PEAWVNAFLGRIFWDFLGEKYWANVISKKIQMKLSKI RLPYVMNELTLTELDMGFSIPKILQASAPTVDHQGLWFDLEVCYTGSFLMTLETKLNLAR LGKE--GEGL--GEHGKEW--PRTYCLADSDEESSSAGSSDEEDPPE------------- --------L-LSDKAILP----GGEGYVGGHRPSKIMRFVDKIAKSKYFQKATETEFIKK KMEEVSNTPLLLTVEVQECRGTLAVNIPPPPTDRIWYGFRSPPHLELKARPKLGEREVTL AHVTDWIERKLDQEFQ-------------------------------------------- ------------------------------------------------------------ --------------------------------------------------KIFVMPNMDD VWLPIMHSAMDTRSNA-------------------------------------------- ------------------------------------------------------------ ---------------SLAP--VTNDASKD---P-----EPA------------------- ---------ES-DV-SDL------CKI- >ENSTNIP00000021153 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------SGQHAEA-----------------------PRQ --------ASGPR-----------------------LQVQRSLSRDTITIHFSALGK-EE EDEE-----------------------E-E--LY-------------------------- ------------------------------------------------------------ ------G-----------------LGR-----------------QGVDDPLTTGSEARED LEFESSGLQASSDAVVSTLEESDVLQ---------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -HAPSSARTISSPCGHSRLGSNP----------------------------STS------ --------------------------------------------------SSWP------ -----------------------------SD--------------------RPLAN---- ------------------------------------------------------------ --------------------------------------------------PPGPGFSS-- ---------------------------------------------------------SSP GR-------A-------------------GPPPS--------------------SKPFL- S---------LVRSLSND-VES-QAAQG----------PPA---------AAPL------ ------H-V-----RHR-HLMKTLVKSLSTDT-EQ------------------------- -----QQAQQVQPP------QRSSP-----RNMQLFKQFSQPR----------LA-SCPV PVTHA--GGD-SKTAPSSPIMSP-DGR---SF-FKVQEVEARIEDTKRRLSEVMSDPLQL FSKIMGDES---GAGAV--------------------------------------G---- GA----------PHRAKLLSSSASELTGMTAVN-GHAEG---NSS-YCI----------- ----------------------------LKAKG--------------------------- ---------------------------------------------------------S-- ----------------------------------------------DVMFFS-------- ------------------------------------------------------------ ----LPSLAPAPALGQASSGSLPRS----------------------------------- --------PSL------------------TLGRCSMSALVARQEDEDFCQLYSQDF---- ----------------------------------------------------DLCAAAET PDE--------------------------------------------------------- ----------------------DCSASQRPYTGDTGTCGDLDT----------------- ------------------------------------------------------------ -----------------------------------------------------------E EEKK-------------------------------------------------------- ------------------------------------------------------------ ---------------------------------------------------------M-- ---LER--------------QSAPVTGLVFLTQLVYLYLACPVPPYVCALVHGIVAGFAL ALLLLWLSSP---------------------------------R---------------- -------------R-SS-PGT-----------RAW---------RRR-------AERW-- ----------------NVAH-----------------LDIKEPGIFKGWMNEIHSYDPEM YHATLTHSVYVRLEGSVLRLSKPNRNISRRAAHNE--PKPDVNFVSQKIYDLTDSKIQLL PQSLARKRVWNKKYPICIELARQDDFMSK------------------------------- -AQGE------------------------------------------------------- ----------K-------------------------------SETGEDK----------- ------------------------------------------------------------ --------------------------------PQGTGERPERSDT-E-----GSAEEPRR R----------------------------------------------------------- ---------PS--GG-------------------G------------------------- -----------------------------------DL----------------------- --------------TIYLFGRTGREKEEWFRRFLLASR---------------------- -----------------------LKSEG-------------------------------K GG--SLA----AISK-------------------------S------------------- ------------------A--FWPSH--SGSTHSC-GGLEADSRS------------SSR GSLEEL--SQS--R-------------SAG-A---------------------------- ---AKQKAMLDYGVYMAKYV---------------Q-----PQ----------------- ---------------AP--LRSP----TASE----GAR---------------------- ------------------------------------------------------------ ---------QSPESSPQSTQK---M---------G-QS---------------------- ----------SE--EAVE-----PEAWVNAFLGRIFWDFLGEKYWANIISKKIQMKLSKI RLPYVMNELTLTELDMGFSIPKVLQASAPTVDHQGLWFDLEVCYTGSFLMTLETKLNLAR LGKE--GEGL--REQGKEWSRPRTYCLADSDEESSSAGSSDEEDPPE------------- --------L-LSDKSVLP----GGEGYVGGHRPSKIMRFVDKIAKSKYFQKATETEFIKK KMEEVANTPLLLTVEVQECRGTLAVNIPPPHTDRIWYGFRSPPHLELKARPKLGEREVTL AHVTDWIERKLDQEFQ-------------------------------------------- ------------------------------------------------------------ --------------------------------------------------KIFVMPNMDD VWLPIMHSAMDTRSNA-------------------------------------------- ------------------------------------------------------------ ---------------SLVA--MTNDASKD---P-----E--------------------- ---------------------------- >ENSPMGP00000025309 ----------------------------M------------------------------- ------------------------------------------------------------ -------------------------------------------TSIA------------- ---------------------------NGQHVDTP-P--------------------SRH --------NPGPK-----------------------LQVQRSHSRDTITIHFSALGK-EE DEEE----------------------------LY-------------------------- -------------------LPKTSGHETREELLYEPLAEEASSSSSAAMTITSPHQNPVV TN---------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------TS------ --------------------------------------------------SSWP------ -----------------------------SE--------------------RPLA----- ------------------------------------------------------------ --------------------------------------------------GPSTSSYT-- ---------------------------------------------------------SSP CK-------S-------------------TPLSS--------------------SKPFL- S---------LVRSLSND-VESREPPSV----------PTT---------VAPT------ ------H-V-----RHR-HLMKSFVKSLSTEA-SK--------------D--PESTHPYQ HALP----------------SRPPP-----RNMQLFKQFSQPR----------LS-TSPV VVTQA--GGD-SKTAPSSPIRSP-DGR---SF-FKVQEVEAKIEDTKRRLSEVMSDPMQL FSKIIGDESGGMGGGYG--------------------------------------G---- SG----------GHRGKSLSSSASELSGVGAVN-GHSDA---NSS-YSIK-EESA--EA- E--------------------EEDEEETPIGKP--------------------------- ---------------------------------------------------------P-- ----------------------------------------------DSVFFS-------- ------------------------------------------------------------ ----FPSLPTIP---------LSKS----------------------------------- --------PSL------------------TLGRCSMSALVARQEDEDFCELYSEDF---- ----------------------------------------------------DICTDTET PDG--------------------------------------------------------- ----------------------SQPICRHPQTVSTGL-------SEWDLDEDDTY----- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----EV--------------EAIPVTALILLTQLVYWYLILPLPPYMYSVIHGVMAGFML ALLVLWLSAP---------------------------------R---------------- -------------I-SS-SGM-----------RRC---------RRR-------VDNW-- ----------------NVAQ-----------------LDIKEPGIFKGWMNEIANYDPEM YHATLTHSVYVRLEGSVLRLSKPNRNISRRATHNE--PKPDVTYISQKIYDLTNSKIYLM PQSLARKRVWNKKYPICIELAKQDDFLSK------------------------------- -AQGE------------------------------------------------------- ----------K-------------------------------VEPAEDR----------- ------------------------------------------------------------ --------------------------------TTGLSEKVEKVDKCEKPE----AEELKR P----------------------------------------------------------- ---------AS--GG-------------------G------------------------- -----------------------------------DL----------------------- --------------TIYLFGRTGREKEEWFRRFLLASR---------------------- -----------------------LKLEP-------------------------------R -----LP----AISK-------------------------S------------------- ------------------A--FLPAHSRSSSPQTS-VCLEAESRS------------SSR GSLEEV--SQ-----------------------------VQGRSKDPPPTTTLPCPITG- ---AKQKMLLDYNVYMAKYV---------------T-----AQ----------------- ---------------AP--PRSP----TGKD----SSG---------------------- ------------------------------------------------------------ ---------NSPESSPKATQK---E---------Q-RS---------------------- ----------SE--GPAE-----PEAWVNAFLGRIFWDFLGEKYWADVVSKKIQMKLSKI RLPYVMNELTLTELDMGCSIPKILHASKPSVDHQGLWFDLEITYAGSFLMTLETKMNLAR LGKE--GEGL--GEQGKEWSRPRTYCLADSDEESSSAGSSDEEEPPE------------- --------L-LSDKTILP----GGEGYVGGHRPSKIMRFVDKIAKSKYFQKATETEFIKK KMEEVSNTPLLLTVEVQECKGTLAVNIPPPPTDRIWYGFRTPPHLELKARPKLGEREVTL GHVTDWIEKKLNQEFQ-------------------------------------------- ------------------------------------------------------------ --------------------------------------------------KIFVMPNMDD VWLPLMHSAMDTRSNV-------------------------------------------- ------------------------------------------------------------ ---------------NLVT--VTNEALKD---P-----ELS------------------- ---------ES-EV-SELET-------- >ENSELUP00000029085 ----------------------------M------------------------------- ------------------------------------------------------------ -------------------------------------------TSQG------------- ------------------SS----RK-DGHATDTP-PSSS---------------MHSRP --------PPGPK-----------------------LQVQRSLSRDTITIHFSALGK-EE DEED-----------------------E-E--LY-------------------------- ------------------------------------------------------------ ------G-----------------FG---------------------------------- ----------------------------TPASSTSPGQGLERLA---------------- -----------GMQG-----------------------------------K--------- ------------------------------------------------------------ ------------------------------------------------------------ -----------TDDRGILT--------------ALEASEELL------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------LFEA-GELESTTTSAPVLP--------------------------- -------------------------------------------------V---------- SSST---------------------------APHSPALPILQTS---------------- ----------------------------SYPNLH-------------------------- ---------------------SP----------------------------PAS------ --------------------------------------------------SSWP------ -----------------------------SEN------------------IRPSIP---- ------------------------------------------------------------ --------------------------------------------------PPSSSSTT-- ---------------------------------------------------------SSP AR-------S-------------------ACL-P--------------------SKPFL- S---------L-RSLSNE-M--------------------M---------VAPP------ ------S-SG---GRHRHHLMKTFVKSISTDN-TRPDHQE-------------------- --------AQSLSQ------HRPAPPDSRINNLQLFKQFSQPR----------ES-SVSV -------GGD-SKTAPSSPLTSPADGR---SF-FKVQEMEARIEDTRRRLSEVMCEPMQL FSKFMGDEA---GGPAD--------------------------------------GG-AT AA----------THRSKSLSVSATELTNLVSLN-GHAES---NNN-YSIKEEEAVDTEG- E--------------------E--EEETPTCEAQVTDFSSHQVQTHRTCRVFS------- -------------------------------------------------------PPP-- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------LPRS----------------------------------- --------SSL------------------ALGRCSMSAL-ARLEDEEFCELYSADF---- ----------------------------------------------------EPCADPET LHG--------------------------------------------------------- ----------------------ERPVSRQPQTSSTGVCSE-------------------- ------------------------------------------------------------ ----------------------------------------------------------TE YREV-------------------------------------------------------- ------------------------------------------------------------ ---------------------------------------------------------E-- ---EDL--------------ANVPITGLLLITCVVYSYLVLPQPPYVCAVVQGLAAGFML AILLLWMSAP---------------------------------G---------------- -------------G-SSYSGT-----------RRA---------RCR-------GEQW-- ----------------NVAQ-----------------LDIKEPGIFKGWMNQMYSYDPEM YHATLTHSVYVRLEGSTLRLSKPNRNIARRATHNE--PKPDVIYISQKIYDLTNSKIHLV PQSLARKRVWNKKYPICIELAKQEDFMAK------------------------------- -AQGE------------------------------------------------------- ----------R-------------------------------PEPGEEK----------- ------------------------------------------------------------ --------------------------------L-------EKVD---------------- ------------------------------------------------------------ ------------GPG-------------------GAVGGED------------------- -------------------------------PRERDL----------------------- --------------ILFLFGRTGREKEEWFRRILLASK---------------------- -----------------------LKSQ--------------------------------- ------------------------------------------ANKLPSERPVSER----- --PHI---------------------------------LEADSRS------------SSR SSLTDEP-SQK--EHSLV-----------G-G---------------------------- ---VRQKMLLDYNVYMVKYV---------------N-----PP----------------- ---------------AP--PDSP----PAS-----SPT---------------------- ------------------------------------------------------------ ---------HSPEGSPGANKK---L---------H-RSL--------------------C ERLGEGQRPV-------------PEAWVNALIGRVFWDFLVEKYWADMVSKKIQMKLSKI RLPYFMNELTLTALDMGFSIPKILHASEPTVDHQGLWFDLEVSYAGSFIMTLETKMNLAR LGKE--GEGP--GEQGKEGPRPRAYCLADSDEESSSAGSSDEEDPPE------------- ----------------VPVDMLGAEGFVGGHRPSKIMRFVDKIAKSKYFQKATETEFIKK KMEEVSNTPLLLTVEVQECRGTLAVNIPPPPTDRIWYGFRSPPRLELKARPKLGEREVTL AHVTDWIEKKLDQEFQ-------------------------------------------- ------------------------------------------------------------ --------------------------------------------------KIFVMPNMDD LWLPIMHSAMDTRSYA-------------------------------------------- ------------------------------------------------------------ ---------------NLVTGRTTTNALRD---P-----DLM------------------- ---------EP-EL-FDM---------- >ENSPKIP00000021272 ----------------------------M------------------------------- ------------------------------------------------------------ -------------------------------------------TARS------------- ----------------------------SSHAGRL-GPVS-----------------TRP --------AAAPK-----------------------LQVQRSLSRETITIHFSALGK-EE EEEE-----------------------D-E--LY-------------------------- ------------------------------------------------------------ ------G-----------------VGTSTS-----AAEGLDYESHG-------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------VVT--------------ALEACEDL------------------- ---------------------------------QFE-G---------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------SGSDSSV PLSEAAVLPVSSTTLPPVSGPQQSAPHSQSPALSILASSFDTPCSSTTVSSSWP------ -----------------------------SGQKTPAPPP--------------------- ------------------------------------------------------------ --------------------------------------------------TPSCASSG-- ---------------------------------------------------------SSP YK-------S--------------------ALPS-------------------IDKPLM- S---------LVKSLSTE-AEPREGLA------------------------TPP------ ------T-V-----RHR-HLMKTLVKSLSTDT-SRQEPD--------------------- -----------VVH------YRQPD--SR-LNLHLFKPFAQPR----------VT-VA-- --------GD-SKTAPSSPLTSP-DSR---SF-FKVSEVEARIEDTKRRLSEVMYEPLQL LSKIMGDE----SG-----------------------------------------A---- SS----------GPRHKALSSSASELCNLASIN-GHLES---NNN-YSIKEEECD-SEG- EC---------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------LAGEEAPTAGAPGPRTTTFALEKCSMSAL-ARQEDEEFCELYSEDF---- ----------------------------------------------------EVNTDTET -DG--------------------------------------------------------- ----------------------DGQ----------------------------------- --EEV------------------------------------------------------- ----------VPASPSARRVSATASMGAGARGS--------------------------D EVE--------------------------------------------------------- --E--------------------------------------------------------- ------------------------------EEPP-------------------------- --------------------PAIPQATLLALTIAIYGYFVLPLPTYVGGMLLGVALGFML AIGVVWLAAPGR-----------SGSRPRHRKLTAE-------Q---------------- ---------------------------------------------------------W-- ----------------NVAR-----------------LDIKEPSMFKGWMNEIHNYDPET YHATLTHSVFVRLEGSTLRLSKPNRNIARRATVNE--PKPDITYISQKIYDLTDSKIYLV PPSLARKRVWNKKYPICIELGKQDDFMSK------------------------------- -AEAD------------------------------------------------------- ----------K-------------------------------GDAGEER----------- ------------------------------------------------------------ ------------------------------------------------------------ --ATP---------------------------------------AE--KEACGTGEDAKR APATQDGARASV------------------------------------------------ ---------------------------------HKEQ----------------------- --------------TLYLFGRTGREKEEWFRRMLVASK---------------------- -----------------------LKSDA-KKPTS-------------------------- -----LPASK------------------------------S------------------- ------------------A--MLTTH----------------SRS------------SSR GSLDELLAGQP--RQKDL----------AG-G---------------------------- ---GRQKMLLDYEVFMAKYM---------------P-----PQ----------------- -------------------PGSP----AG------SPI---------------------- ------------------------------------------------------------ ---------HSAESSPGAGKK---L---------P-SR---------------------- ----------PG--PEEE-----PVAWVNALVGRIFWDFLGEKYWADMVSKKIQMKLSKI RLPYFMNELTLTELDMGVAVPKILHASEPSVDHQGLWFDLEISYNGSFLMTLETKMNLVR LGKE--GDAVRPGEPGKDGHRPRTYCLADSDEESSSAGSSDEEDPPE------------- --------I-PPDKNPLP----GAEGYVGGHKPSKIMRFVDKITKSKYFQKATETEFIKK KMEEVSNTPLLLTVEVQECRGTLAVNIPPPPTDRIWYGFRTPPHLELKARPKLGEREVTL AHVTDWIERKLDQEFQ-------------------------------------------- ------------------------------------------------------------ --------------------------------------------------KIFVMPNMDD VWLHIMHSAMD------------------------------------------------- -----------------------------PRSGSGPG-----------------PV---- ----AEETESAKDTDSMAT----------------------------------------- ---------EPLPI-GDM---------- >ENSSFOP00015008632 ----------------------------M------------------------------- ------------------------------------------------------------ -------------------------------------------TSRS------------- ----------------------------SSHAERL-GPTS-----------------LRP --------TATPK-----------------------LQVQRSVSKETITIHFSALGK-EE EEEE-----------------------E-E--LY-------------------------- ------------------------------------------------------------ ---------------------------------------------GP------------- ---------------------------------------------SVLA----------- ----------------SSAL---------------------------------------- -GME-------------------------------------------------------- ------------------------------------------------------------ -----------HEDQSVVT--------------ALEASEDL------------------- ---------------------------------QFE-GGLEPV----------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------AS------ --SEIAVLPVSSTTLPPVSIPQASVPHTQSSALSILPSSLHTASSSSTTSSSWP------ -----------------------------SGQKIPGCPP--------------------- ------------------------------------------------------------ --------------------------------------------------APSSASSS-- ---------------------------------------------------------SSP YK-------S-------------------VALPS-------------------IDKPFM- S---------LVKSLSTE-AEPREGLV------------------------TPP------ ------S-I-----RHR-HLMKNLVKSLSTDT-SRQDQD--------------------- -----------SGS------HRLPD--SR-LNLHLFKQFTQPR----------VS-VT-- --------SD-SKTAPSSPLTSP-DSR---SF-FKVAEVEARIEDTKRRLSEVIYEPLQL LSKIIGDES---SG-----------------------------------------G---- GG----------GHRHKALSSSASELSNLASLN-GHLES---NNN-YSIKEEECD-SEG- ECL--------------------------------------------------------- ---------------------------------------------------------PEA EVDV------------------------------------AETRS--------------- ------------------------------------------------------------ -----P-----------------KA----------------------------------- --------SSL------------------ALDKCSMSAL-ARQEDEEFCELYSEDF---- ----------------------------------------------------ETNTDT-- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --EAEA---------------------------DVPGEVARRARPVQGTEADILSDDEAD V-----------------------------EEPA-------------------------- --------------------PTVPYAFLLALTALIYSYFVLPLPSYLGGLLFGAAVGFML AIGIVWLSAPGRVSYGSERSRRK-----------AE-------R---------------- ---------------------------------------------------------W-- ----------------KAAR-----------------LDIKEPGVFKGWMNEIHSYDPET YHATLTHSVFVRLDGSTLRLSKPNRNISRRAMFNE--PKPDVTYVSQKIYDLTDSKIYLV PPSLARKRVWNKKYPICIELGKQEDFMSK------------------------------- -AEAD------------------------------------------------------- ----------K-------------------------------G----------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------V-TG-------------------D----EDG------------------ SGGGEEIKRPP--GTQE----------SMRLSAHKEQ----------------------- --------------TLFLFGRTGREKEEWFRRILLASK---------------------- -----------------------LKSET-KKPTSITGNKS----------------GKHR GHNPVLP----------------------------------------------------- ------------------------TH----------------SRS------------SSR GSLDELLASQP--RQREL----------TS-G---------------------------- ---VRHKVLLDYAVYMAQYV---------------P-----TQ----------------- -------------------GGSP----AG------SPV---------------------- ------------------------------------------------------------ ---------HSTESSPGAGKK---L---------P-SC---------------------- ----------PG--PEQE-----PVSWVNALVGRIFWDFLGEKYWADMVSKKIQMKLSKI RLPYFMNELTLTELDMGVAIPKILQASKPSVDHQGLWFDLEISYNGSFLMTLETKMNLAR LGKE--GEGLRPGEPGKEGHRPRMYCLADSDEESSSAGSSDEEDPPE------------- --------M-STDKNLPP----GAEGFVGGHKPSKIMRFVDKITKSKYFQKATETEFIKK KMEEVSNTPLLLTVEVQECRGTLAVNIPPPPTDRIWYGFRSPPRLELKARPKLGEREVTL AHVTDWIEKKLDQEFQ-------------------------------------------- ------------------------------------------------------------ --------------------------------------------------KIFVMPNMDD VWLPIMHSAMDTRS---------------------------------------------- ----NITPVAVTTEVTKDPDSVEAEADPHPTS---------------------------- ------------------------------------------------------------ ----------------DM---------- >ENSLOCP00000016884 ----------------------------M------------------------------- ------------------------------------------------------------ -------------------------------------------TSRS------------- ----------------------------RGHAEKS-GPPS-----------------SKP --------PAAPK-----------------------LQVQRSLSRENITIHFSAFGK-EE EEEE-----------------------V-E--LY-------------------------- ------------------------------------------------------------ ------G-----------------AAASSS-----APD--DFD----------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------DQSIVT--------------AVEASEDL------------------- ---------------------------------QFDAGGLDPVD---------------- ----------------------------LTASANVSVSSSAQPPVSAGPAAGVPQSPGPL RSSPALSILSSPSSHAGSSAG--------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------------PAS------ --------------------------------------------------SSWP------ -----------------------------SEQK----PPAA------------------- -----------APA---------------------------------------------- -------------------------------------------------AAASSSSST-- ---------------------------------------------------------SSP SK-------S-------------------IALSS-------------------GAKPFL- S---------LVKSLSTE-VEPKD---------------------------STT------ ------S-L-----RHR-HLMKTLVKSLSTDT-SRQDTD--------------------- -----------STS------SRPPD--SR-LNLHLFKQFTQPR----------VT-SA-- --------GD-SKTAPSSPLTSP-DSR---SF-FKVPEVEARIEDTKRRLSEVIYEPLQL LSKIMGDE-----G-----------------------------------------G---- AG----------GHRHKALSSSASELSSLAGLN-GHLES---NNN-YSIKEEEFD-SEG- EYLL---------GDSTPDRRE------------------------------STAGVPEP AKDAADAK-----------------SSPATGTREARS-------------------LP-- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------L------------------VLEKCSLSAL-AKQEDEEFCELYSEDF---- ----------------------------------------------------EVCTDTET -DG--------------------------------------------------------- ----------------------DKP----------------------------------- --EEAVLEAAL------------------TQG------------------------DSTG VCSEDELDDDV------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------PA-------------------------- --------------------PSVPSKTLFVLITLLYGYFVLPLPTYVCGMLLGAAAGFLI AIGVVWLSTP---------------------------------R---------------- -------------G-SG-YQR-----------RHT---------KRK-------DCLW-- ----------------NVAH-----------------LDIKEPDLFKGWMNEICNYDPET YHATLTHSVFVRLEGCTLRLSKPNRNISRRASFNE--PKPDVTYISQKIYDLTDSKIYLV PPSLARKRVWNKKYPICIELGKQEDFMSK------------------------------- -AQGD------------------------------------------------------- ----------RDRES-----------------------GEERGEA--------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------G-------------------G----EDG------------------ -----------------------------RAPAHRDQ----------------------- --------------TLFLFGRTGREKEEWFRRILLAAK---------------------- -----------------------LKSEA-KKTPS-------------------------- -----LPGTKAG--KEPPQQSRDLTARTRVRFPVF---TTS------------------- ------------------A--FLPSH----------------SRS------------SSK GSVDEAL-PQP--RPKEP----------SA-S---------------------------- ---VRQKMLLDYTVYMAKYV---------------P-----PQ----------------- -------------------PGSP----AA------SPL---------------------- ------------------------------------------------------------ ---------HSADSSPSTSKK---L---------P-GG---------------------- ----------QG--EAEE-----PEAWVNALLGRIFWDFLGEKYWADLVSKKIQMKLSKI RLPYFMNELTLTELDMGVAVPKILQASKPSVDHQGLWFDLEISYNGSFLMTLETKMNLTR LGKEPLGEGLRFGETGKEGARPRTYCLADSDEESSSAGSSDEEDPPE------------- --------VTAADKSLVP----GAEGYVGGHRASKIMRFVDKITKSKYFQKATETEFIKK KIEEVSNTPLLLTVEVQECRGTLAVNIPPPPTDRVWYGFRSPPHLELKARPKLGEREVTL AHVTDWIEKKLDQEFQ-------------------------------------------- ------------------------------------------------------------ --------------------------------------------------KIFVMPNMDD LYVPIMHSAMDARSQA-----------ALA------------------PAADPPRDQGEA EPCAE------------------------------------------------------- ------------------------------------------------------------ ---------------GQM---------- >ENSECRP00000026392 ----------------------------M------------------------------- ------------------------------------------------------------ -------------------------------------------TSPS------------- ----------------------------SSHAENP-GAMS-----------------SKP --------PAMPK-----------------------LQVQRSLSRETITIHFSAFGK-EE EEEE-----------------------E-E--LY-------------------------- ------------------------------------------------------------ ------G-------------------GSSS-----SPE---------------------- ------------------------------------------------------------ ------------------------------------------------------------ ---E-------------------------------------------------------- ------------------------------------------------------------ -----------LEDQRIVT--------------ALEAKEDL------------------- ---------------------------------LFETGGQFPVDSSTSHSVAALPASSFS STLSQSLEASDPQVSSSAISGMPVATTKL------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------AS------ --------------------------------------------------TSWP------ -----------------------------SEHK-------AVALLSSSGHTRPVVLSSGL SAS-------VAQ----------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------GSKPLV- S---------LVKSLSTE-VEPKE---------------------------ASP------ ------S-P-----RHR-HLMKTLVKSLSTDT-SKQETE--------------------- -----------SVS------YRQPD--SR-LNLHLFKQFTQPR----------VT--S-- --------SD-SKTAPSSPLTSPLDGR---SF-FKVPEVEARIEDTKRRLSEVIYEPLQL LSKIIGDE----GS-----------------------------------------S---- SA----------SHKPKALSSSASELTSLASLN-GHLES---NNN-YSIKEEECD-SEG- ECL--------------------------------------------------------- ------------------------------------------------------------ QIDTEPAAREVPLDLLQEETLGESKTLAASATKDDRNNASS------------------- ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------VLDKCSLSAL-ASKEDEEFCELYSEDF---- ----------------------------------------------------ELETEAE- ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------GLEELPEGKTVSPRESLDVGSEDEEDET- ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------PIQ------------- ------------------------------------------------------------ --------------------PNVPCKTLFFLIMLVYAYLVLPLPTYLRGLFLGVALGFMT AVGVVWVATL---------------------------------K---------------- -------------G-TG-HQRLA------KRRKHP----------------------W-- ----------------NTAQ-----------------LDIKEPGIFKGWMNEIHSYNPET YHATLTHSVFVRLEGNTLRLSKPNKNISRRASFNE--ARPDITYVSQKIYDVTESKIYLL PQNLARKRIWNKKYPICIELGKQDDFMSK------------------------------- -AQPD------------------------------------------------------- ----------RD------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------G-------------------A----EEGKNEVSADEEKKSLLAHDK S----------------------------RPSSHKDQ----------------------- --------------TLYLFGRTGREKEEWFRRILLAST---------------------- -----------------------LKSKS-KKPSS-------------------------- -----LPGAK------------------------------S------------------- ------------------G--LVPTH----------------SRSNSHSGVLTHSRNSSK GSLDEVM-SQP--KQKEL----------VA-G---------------------------- ---VRQKTLLDYSVYMAKYI---------------P-----V------------------ -------------------SSSP----SGLSPAVLSPV---------------------- ------------------------------------------------------------ ---------HSSDSSPASPSK---L---------P-AS---------------------- ----------QT--GKDD-----SEAWVNALVGRIFWDFLCEKYWSDVVSKKIQMKLSKI RLPYFMNELTLTELDMGVAVPKICKAYKPSINHQGLWCDLEVSYTGSFLMTLETKMNLTR LGKDLPGEGPRPGDSGREGGRPRTYCLADSDEESSSAGSSDEEDPPE------------- --------ATAGDKPLAP----GAESYIGGHRASKIMRFVDKITKSKYFQKATETEFIKK KMEEVSNTPLLLTVEVQECHGTLAVNIPPPPTDRIWYGFRSPPHLELKARPKLGEREVTL AHVTDWIEKKLEQEFQ-------------------------------------------- ------------------------------------------------------------ --------------------------------------------------KIFVMPNMDD VYIPIMHSAMDPRSAARQDCAKEVGLDA-------------------------------- ---------------------------------AGP------------------------ ------------------------------------------------------------ -----------------R---------- >ENSCHAP00000047754 ----------------------------M------------------------------- ------------------------------------------------------------ -------------------------------------------TSRQ------------- ----------------------------GGHAEKPLPPST-----------------SRP --------PAAPR-----------------------LQVQRSLSRDNITIHFSALGK-EE EEEE-----------------------E-E--LY-------------------------- ------------------------------------------------------------ ------W-----------------TTVSSS-----PPS---------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------TVLAGNADDVSKIAEALEASEEM------------------- ---------------------------------EY------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------GVDSVNSV TDPTVLPMFSSSSTVTLPPMSGPQDQGPTQPFTFGSLSTAAKGPAATQVHTSATSKSSSP SR-------S-------------------ITLTS-------------------TDKPFF- S---------LIKSLSSD-LEPREGVP------------------------LGP------ ------T-V-----SHR-QLMKNLVKSLSSDT-SQE--A--------------------- -----------SGS------FRLPD--SR--SLQLFKQFTQPR----------GA-AASS V---T--GGD-SKTAPSSPLTSP-DSR----FGFKVSEVEARIEDTKRRLSEVMFEPLQL LSKMIGDES---AS-----------------------------------------T---- GS----------LYRPKGLSSSASELSNLASFN-GHLES---NNN-YSIKEEEGD-SDE- EGAANASSVAESLTDT-------------------------------------------- -----------------------------------RGVKPG---------------MP-- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------L------------------ALEKCSMSAL-ARQEDEEFYELYSEDF---- ----------------------------------------------------DF--DNET -DG--------------------------------------------------------- ----------------------DRP----------------------------------- --DD-------------------------------------------------------- -----------------------------------------SIARSKGHHLLNTDTFIED ELE---------------------------------------------G----------- ------------------------------------------------------------ ------------------------------EEPD-------------------------- --------------------PSIPLKTLFALTLITYGYFVLPLPTYVGGMFFGTFLGFML AVGVIWLAGP---------------------------------R---------------- -------------R-SG-GAA-----------GHK---------RIK-------KEMC-- ----------------NTAQ-----------------LDIKEPGMFKGWMNEIQNYDPET YHATLTHSVFVRLEGSTLRLSKPNRNVARRATINE--PKHDICYVSQKIFDLTDSKIHLV PQSLARKRVWNKKYPVCIELGKQDDFMSK------------------------------- -AESE------------------------------------------------------- ----------------------------------------------ADE----------- ------------------------------------------------------------ ------------------------------------------------------------ --ERP------------------------------------------------------- ------------------------------------------------------------ -------------------------------------ADSLLEKSEVAAGAGVEEAKRPG QEACRPSGSKSHLATLYLFGRTGREKEEWFQRLLVASR---------------------- -----------------------LKAETAKKAAS-------------------------- -----LPVSK-----------------------------SS------------------- ------------------A--TLTSH----------------SRS------------SSR SSLDELF-SQP--RQKDS------------------------------------------ --------------------------------------------------SGPAPARPRP ALDYSDYMGRCMPPEEPQVGSAP----AS------SPQ---------------------- ------------------------------------------------------------ ---------QSPHSSPAASKK---L---------P-GI---------------------- ----------QV--KEDE-----SVAWVNALVGRVAWDFLGEKYWVDWVSKKIQMKLSKI RLPYFMNELTLTELDMGLSTPRILQASKPSVDHQGLWFDLEIAYKGSFLMTLETKMNLAR LGKE--GEGF--GEFGKDGSRPRAYCLADSDEESSSAGSSDEEDPSE------------- --------L-TPDQT--A----GAEGYVGGHKPSKIMRFVDKITKSKYFQKATETEFIKK KMEEVSNTPLLLTVEVQEIRGTLAVNIPPPPTDRIWYGFRTPPRLDLKARPKLGEREVTF AHVTDWIEKKLYQEFQVYQLITLLPHTSSTGSLEGSLGFSKGFSRGFSKGFSRGFSKGFS GGFSHAPAHRCFPSLTPHSLSPSAENPGDAQHGRPVAPHHALRHGPTLSPGPLRERSAPL QRPVRRGAALQYSVRWWCTALAPTHTNGSCDRTTPTLPTAPSAPGATFQMK--------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------GSL---------- >ENSDCDP00000058034 ----------------------------M------------------------------- ------------------------------------------------------------ -------------------------------------------TSSP------------- ----------------------------GGHHERP-PPSN-----------------VRP --------PAAPK-----------------------LHVHRSQSRETITIHFSALGE-EE EEEELYGAAMTSTSAAVAIDDDCSIST--------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------ALEASEEL------------------- ---------------------------------EFEPGG--------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------SS------ -ETEVPVIPVTSTMM--------------------------------------------- ------------------------------------------------GH---------- --SSGVRDQEVAQSYLSDSTSTSKEPISVLA----------------------------- ---------------------------------------------------PSTSSVN-- ---------------------------------------------------------TSP SK-------S-------------------VSLPS-------------------SDKPFL- N---------IMKSLSTD-VEPREGVP------------------------IAP------ ------T-V-----RHR-QLMKNLVKSLSTET-SQD--S--------------------- -----------QGS------YRLLD--SR-LNLQLFKQFTQPR----------AT-GSS- ---------D-SKTAPTSPITSP-DSR----FSFKVSEVEARIEDTKRRLSEVMYEPLQL FSKIIGDES---SA-----------------------------------------S---- GS----------YYRPKALSTSASEITNLASLN-GHMES--NNNN-YSIKEEDGD-SDG- EDVANAAATAE------------------------------------------------- ---------------------------------------------------------PP- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------AA--------------------------------AT NPQSAKPAQSL------------------ALDKCSMSAL-AKQEDEEFCELYSEDF---- ----------------------------------------------------DFYTDTEA -EG--------------------------------------------------------- ----------------------DRT----------------------------------- --D--------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------DTTTESKVQPFLSTETCSEDKTDLE-- ---EQV--------------PSIPHTTLFALTVIIYGCFVLPLPTYVGGMLLGVALGFML AIGVVWLGGP---------------------------------R---------------- -------------R-SG-EVA-----------GHS---------RHK-------WNPW-- ----------------NVTQ-----------------LDIKEPGMFKGWMNEIHNYDPET YHATLTHSVFVRLDGSILRLSRPNRNIARRATFNE--PKPDVTYVSQKIFDLTDSKIYLV PQSLARKRIWNKKYPICIELAKQDDFMSK------------------------------- -AEGE------------------------------------------------------- ----------------------------------------------TTE----------- ------------------------------------------------------------ ------------------------------------------------------------ --DKPITSERSEVTNEQSDGPVVVEEDKKNTLAAQETSRSALLKG--------------- ------------------------------------------------------------ -----------------------------------HQ----------------------- --------------TLYLFGRTGREKEEWFQMLLLASR---------------------- -----------------------LKAEAAKKAAV-------------------------- -----LPLSK------------------------------S------------------- ------------------V--PITSH----------------SRS------------SSR GSLDELLSSQP--RQKET---------VAA-A---------------------------- ---ARHKALLEYSVYMANYI---------------P-----PATQPPGSLAG-------- -----------------------------------SPL---------------------- ------------------------------------------------------------ ---------QSPHSSPGAGKK---L---------P-CS---------------------- ----------PV--KEEE-----TVAWVNALVGRIAWDFLGEKHWAQWVSKKIQMKLSKI RLPYFMNELTLTELDMGISTPRILQASMPSVDHRGLWFDLEISYKGSFLMTLETKMNLAR LGKE--GEGF--GEFGKDGARPRAYCLADSDEESSSAGSSDEDDPPD------------- --------I-TSDKTQLP----GAEGYVGGHKTSKIMRFVDKITKSKYFQKATETEFIKK KMEEVSNTPLLLTVEVQECQGTLAVNIPPPPTDRIWYGFRSPPVLELKARPKLGEREVTL VHVTDWIEKKLYQEFQ-------------------------------------------- ------------------------------------------------------------ --------------------------------------------------KILVMPNMDD IWLHIMHSAMDGRSTT-----------PSSDTEG--------------SQ---------- ------------------------------------------------------------ ------------------------------------------------------------ -------------T-GDI---------- >ENSIPUP00000022330 ----------------------------M------------------------------- ------------------------------------------------------------ -------------------------------------------ASGE------------- ----------------------------DDHVDRP-LLSS-----------------FRP --------SSAPK-----------------------LNVQRSLSRESITIHFSAMGK-EE DQEE-----------------------E-V--IY-------------------------- ------------------------------------------------------------ ------GPL-------------------DL-----PSDT--------------------- ------------------------------------------------------------ ------------------------------------------------------------ ---M-------------------------------------------------------- ------------------------------------------------------------ -----------TTSQGVVT--------------ALEASEDLVLEGDTEMKSV-------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------GNFDAVESLSAMAGQQNTNKQE------HSLTCSTSAEPTKGTGSSSGSAN-- ---------------------------------------------------------ASP SK-------S-------------------VSLPS-------------------MDKAFL- S---------LMKSLSTD-LEPREGVP------------------------VPP------ ------H-L-----RHR-QMMKNFVKSLSTDT-TQD--P--------------------- -----------SGS------NRPSD--SR-LNLHLFKQFTQSR----------AT-ASV- --------GD-SKTAPTSPLTSP-DNR---TFSFKVSEVEARIEDTKRRLSEAMADPLQL ISKFIGDDS---S----------------------------------------------- -S----------IYRPKPLSSSATELTSFSTLN-GHLES---NNN-YSIKEEEGD-LDG- EGVT-------------------------------------------------------- ---------------------------------------PEAAELASAAESKTAKPCP-- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------SSL------------------GLDTCSMSAL-AKQDDQEFCELYSEDF---- ----------------------------------------------------DFSVDTEV -HV--------------------------------------------------------- ----------------------DRT----------------------------------- --EDV----------------------------------KT------------------- -------------------------------GSGASKPASPS-----------TNTFRQD ERELVSAY---------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------SIPRKTLLALTIITYGYFILPLPTYLGGMLLGVALGFML AIGVVWLTGP---------------------------------K---------------- ------------------------------------------------------------ --LQGIRRLRSPRDLWNVAQ-----------------LDIKEPGIFKGWMNEIQNYNPET YHATLTHSVFVRLEGSTLRISKPNKNIARRASYNE--SKPDITYISQKIYDLTDSKVSLV PQSLARKRVWNKKYPVCIELAKQDDFMSK------------------------------- -AEAD------------------------------------------------------- ----------R---ASDEKENQDI---------AGSQEG---GRAGSDR----------- ------------------------------------------------------------ ------------------------------------------------------------ --ELP------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ --------------TIYLFGRTGREKEEWFRRILLASK---------------------- -----------------------LKSEAAKKAAS-------------------------- -----LPTSK------------------------------S------------------- ------------------A--SALSH----------------SRS------------SSR GSLDEFLSSQA--AKKES----------SV-S---------------------------- ---AKQKSLLEYSIYMANYV---------------G-----PSKA--TSANT-------- -----------------------------------SPG---------------------- ------------------------------------------------------------ ---------ASPHSSPSVGKK---L---------P-SS---------------------- ----------PVKEKEEV-----PVSWLNALIGRIAWDFFREQHWSEWVSKKIQMKLSKI RLPYFMNELTLTELDMGWCTPKILSASPPSVDHQGLWFDVEVSYKGSFLMTLETKMNLSR LGKE--GEAV--SEFGKDGHRPRTYCLADSDEESSSAGSSDEEDGTE------------- --------N-VADKNLLS----GAEGYTGVHRPSKIMRFVDKITKSKYFQKATETEFIKK KIEEVSNTPLLLTVELQECKGTLAVNIPPPPTDRIWYGFRSPPLLELKARPKLGEREVTF AHVTDWIEKKLEQEFQ-------------------------------------------- ------------------------------------------------------------ --------------------------------------------------KILVMPNMDD VWLTVMHSAMDPRSDA-----------TAADSKEATTVPEGDVLPSEGP----------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------- >ENSAMXP00000015663 ----------------------------M------------------------------- ------------------------------------------------------------ -------------------------------------------TSKQ------------- ----------------------------GGHVDRP-SLSA-----------------VRP --------SSTSK-----------------------LQVQRSQSRDTITIHFSALGK-ED DDEE-----------------------E-E--LY-------------------------- ------------------------------------------------------------ ------GASG-----------AGGAGTSDS-----STEE--------------------- ------------------------------------------------------------ ------------------------------------------------------------ ---V-------------------------------------------------------- ------------------------------------------------------------ -----------ASSQAIVT--------------ALEASEDLDLGGEPETKPINDVPVLP- --------------------------------VE-------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------TSGLSSTSGQQNTNIQDHNSSTTA SAFSGAT----------------------------------------RGAGPSSGSTE-- ---------------------------------------------------------SSP SK-------S-------------------VSLPS-------------------MDKAFL- N---------LMKSLSTD-VEPREGVP------------------------APS------ ------S-M-----RHR-QIVKSLVKSLSTDT-AQD--P--------------------- -----------AGS------SRPSD--SR-LSLHLFKQFTQPR----------TA-TTV- --------GD-SKTAPSSPLTSP-ENR---PFSFKVSEVEARLEDTKRRFSEVISDPLQL ISKFIGDEA---S----------------------------------------------- -N----------IYRPKPLSSSASESASLSALN-GYPEN---NNN-YSIKEEEGD-LEG- ECTT-------------------------------------------------------- ---------------------------------------PGATEQASAAESKTIKPSP-- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------SSL------------------GLNVCSMSAL-AKQEDEEFCELYSEEF---- ----------------------------------------------------DFSMDTEV -EV--------------------------------------------------------- ----------------------D------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -------HTDVDTK---------------------------------TGSSVCVPASQSV ITS--------------------------------------------------VED---- ---------------------------EMDLEAT-------------------------- --------------------PSIPHKTLFALTVLIYGYFILPLPTYLGGLLLGVALGFML AIGVVWLTGP---------------------------------K---------------- -------------R-AR-IAP-----------RHV---------RQQ-------RALCNV EP-----------------------------------LDIKEPGMFKGWMNEIYSYDPET YHATLTHSVFVRLDGSTLRISKPNKNITRRASYNE--PKPDVIYISQKIYDLTDCKVSLV PPGLARKRIWNKKYPICIELAKQDDFMSK------------------------------- -AEGE------------------------------------------------------- ----------R---TSEDKENTDITVEPRKPSSVSLQDG---GRAGSDR----------- ------------------------------------------------------------ ------------------------------------------------------------ --EPP------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ --------------TIYLFGRTGREKEEWFHRILLASR---------------------- -----------------------LKAETAKKTAS-------------------------- -----LPVSR------------------------------S------------------- ------------------A--PVLSH----------------SRS------------SSR SSLDELLSNQA--ARKES----------SM-S---------------------------- ---AKLNPLLEYSTYMASYI---------------N-----PTTV--GSRST-------- -----------------------------------SPR---------------------- ------------------------------------------------------------ ---------ESPHSSPGVAKK---L---------P-ND---------------------- ----------AV--SEEG-----PVCWVNALIGRIAWDFLREQHWAEWVSKKIQMKLSKI KLPYFMNELTLTELDMGASTPRILCASPPSVDHQGLWFDLEISYKGSFLMTLETKMNLSR LGKE--GEGL--GEFGKEG--PRTYCLADSDEESSSAGSSDEDDGTE------------- --------N-LADKNLPP----GAEGYSGVHRPSKIMRFVDKITKNKYFQKAAETEFIKK KMEEVSNTPLLLTVELQECKGTLAVNIPPPPTDRIWYGFRSPPLLELKARPKLGEREVTL AHVTDWIEKKLEQEFQ-------------------------------------------- ------------------------------------------------------------ --------------------------------------------------KILVMPNMDD VWLHIMHSATDPRTDT-----------PLTDSKGGLNIPEPDSSLPEDP----------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------- >ENSPNAP00000037725 ----------------------------M------------------------------- ------------------------------------------------------------ -------------------------------------------TTRQ------------- ----------------------------GGHVDQT-PFPG-----------------FRP --------SSASK-----------------------LHVQRSQSRETITIHFSALGR-EE EDDE-----------------------E-E--LY-------------------------- ------------------------------------------------------------ -----------------------GVGTSDS-----PSEA--------------------- ------------------------------------------------------------ ------------------------------------------------------------ ---M-------------------------------------------------------- ------------------------------------------------------------ -----------ANSQGIVT--------------ALEASEDLVLEGESEAKSVNNVAVLP- --------------------------------VE-------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------TSVLSTMSGQQNTNSPDHNFTSTA SALAEAK----------------------------------------KGTGPSSGSTN-- ---------------------------------------------------------SSP SK-------S-------------------VSLPS-------------------MDKAFL- N---------LMKSLSTD-VEPREGIP------------------------APS------ --------L-----RHR-QLVKNLVKSLSTDT-AQD--P--------------------- -----------AGS------NRSSD--SR-LNLQMFKQFTQPRT--------TTA-TTV- --------GD-SKTAPSSPLTSP-DNR---PFSFKVSEVEARIEDTKRRLSEVISDPLQL ISKFIGDEA---S----------------------------------------------- -N----------IYRPKPLSSSASESTNLSALN-GHLER---NNN-YSIKEEEGD-LEG- EYTT-------------------------------------------------------- ---------------------------------------QGATEQVSASESKTVKPSP-- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------SSL------------------GLDMCSMSAL-AKQEDEEFCELYSEDFELCP ETELEVDHTEDSKIR------------------SSVCMPTSQSINTFGEDEVDF------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------ETT-------------------------- --------------------PSIPHKTLFALTVLVYGYFVLPLPTYFGGMLLGVALGFML AIGVVWLTGP---------------------------------K---------------- -------------R-AG-ITA-----------RFA---------RHQ-------RQLCNL EH-----------------------------------LDIKEPGIFKGWMNEIYNYDPET YHATLTHSVFVRLDGSTLRISKPNKNITRRASCNE--PKWDVTYISQKIYDLTDSKVSLV PPGLARKRVWNKKYPICIELAKQDDFMSK------------------------------- -AEGE------------------------------------------------------- ----------R---ASEEKENADMPVEPRRASSVNSQDG---GRAGLDR----------- ------------------------------------------------------------ ------------------------------------------------------------ --EPP------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ --------------TVYLFGRTGREKEEWFRRILLASK---------------------- -----------------------LKSETAKKTAS-------------------------- -----LPVSR------------------------------S------------------- ------------------A--PVLSH----------------SRS------------SSR SSLDELLSSPA--SKREM----------CA-S---------------------------- ---AKLKPLLEYSTYMANYI---------------N-----SSTA--CSRAG-------- -----------------------------------SPG---------------------- ------------------------------------------------------------ ---------ESPQSSPGVAKK---L---------P-ND---------------------- ----------SV--KEEG-----PVCWVNALIGRIAWDFLREKHWADWVSKKIQMKLSKI RLPYFMNELTLTELDMGVCTPSILWASQPSVDHQGLWFDLEISYKGSFLMTLETKMNLSR LGKE--GEGL--GEFGKEGHRPRTYCLADSDEESSSAGSSDEDDGTE------------- --------N-VTDKNLPP----GAEGYSGVHRPSKIMRFVDKITKNKYFQKAAETEFIKK KMEEVSNTPLLLTVELQECKGTLAVNIPPPPTDRIWYGFRSPPLLELKARPKLGEREVTL AHVTDWIEKKLEQEFQ-------------------------------------------- ------------------------------------------------------------ --------------------------------------------------KILVMPNMDD VWLHIMHSAMDPRSDT-----------TLTDSKGGVNAPEPDLPLSEGL----------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------- >ENSEEEP00000011100 ----------------------------M------------------------------- ------------------------------------------------------------ -------------------------------------------TSRQ------------- ----------------------------GGHGNQS------------------------P LSSALLPASSAPK-----------------------LHVQRSQSRETITIHFSALGK-DD EDEE-----------------------E-E--LY-------------------------- ------------------------------------------------------------ ------WPSTPNPSSSEATNNR-------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------VIT--------------ALEASEDLVIEGDAEVKSA-------- ---------------------------------EN------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------VAAPLDMSSVMSTMSGQQNTTSQEHSLLSSA SAFARAE----------------------------------------KSPASSSGSTN-- ---------------------------------------------------------SSP SK-------S-------------------TSLPS-------------------MDKAFL- N---------LRKSLSTE-VEPREGVP------------------------VHP------ ------T-L-----RHR-QLVKNLYKSLSTDT-APD--A--------------------- -----------AGS------NRPLD--SR-LNLQLFKPFSQPR----------AS-TS-- ---------D-CKTAPSSPLSSP-DNR---SFSFKVSEVEARIEDTKRRFSEVMSEPLQL ISKFIGDEA---S----------------------------------------------- -S----------IYRPKPVSSSTSELTSLSALG-DHLEN---NNN-YSIKEEEGN-AEG- EGVT-------------------------------------------------------- ---------------------------------------PGATEQALFAESKPVKPSP-- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------SSV------------------GLDKCSMSAL-AKQEDEEFCELYSDDFDAC- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------ADDEAV SQQTEDTKARDHTGFPASRGMDHFIDGEMDLEPA-------------------------- --------------------PRTPNKTLLALTVIIYGYFVLPLPIYVSGMLLGVALGFMV AIGVVWLTGP-------------------------------------------------- ------------------------------------------------------------ ------------------AQPGVANRHRRHRRWNMLHLDVKEPDIFKGWMNEIQNYDPET YHATLTHSVFVRLEGSALRISRPNKNITRRASYSE--PKPDVAFVSQKIYDLTDSKVCLV PPGLARKRVFNKKYPICIELAKQNDFMSK------------------------------- -ADGD------------------------------------------------------- ----------R---ACSEKENPDC--------------------VGKER----------- ------------------------------------------------------------ ------------------------------------------------------------ --EPP------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ --------------IIFLFGRTGREKEEWFRRILLASK---------------------- -----------------------LKSEAAKKSVS-------------------------- -----LSSSR------------------------------T------------------- ---------------------PLLSH----------------SRS------------SSR SSLDELLSSQA--SKRES----------CG-N---------------------------- ---TRQKPLLEYSTYMANYIRSATRDNLVSSSGEA------------------------- -------------------------------------G---------------------- ------------------------------------------------------------ ---------ESPHDTTALDKK---L---------P-GS---------------------- ----------PV--KEEG-----LVSWVNALIGRILWDFLRERHWADWVSKKIQMKLSKI RLPYFMNELTLTELDMGMCTPRILWASQPSVDHQGVWFDLEISYKGSFLMTLETKMNLSR LGKE--TEGL--GEFGKEGHRPRTYCLADSDEESSSAGSSDEDDGTE------------- --------N-VLDKNLLQ----GAEGYTGVHKPSKIMRFVDKLTKNKYFQKATETEFIKK KMEEVSNTPLLLTVELQECQGTLAVNIPPPPTDRIWYGFRSPPKLELKARPKLGEREVTF AHVTDWIEKKLEQEFQ-------------------------------------------- ------------------------------------------------------------ --------------------------------------------------KILVMPNMDD IWLHVMHSATDPRSDT-----------VQTDSRGPASAPDADVPTSEVP----------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------- >ENSAMXP00000050013 ----------------------------M------------------------------- ------------------------------------------------------------ -------------------------------------------TSQG------------- ----------------------------GGNGDTPGPPPSSSSPSA-------SSSFLRP --------SAGPK-----------------------LQVQRSLSRDTITIHFSAQGK-DE EEED-----------------------E-E--LY-------------------------- ------------------------------------------------------------ ------G-----------------LAATTS-----GPDG--------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------DEQGVAT--------------AVEASEELL------------------ ----------------------------------FEGAG--------------------- ------------------------------------------------------------ ---------------TGT------------------------------------------ ---------------------------GPGGLP--------------------------- -------------------------------------------------V---------- SSTV-------------------------------------------------------- ---------------------------------------A-------------------- -------------------SSSPALSI---QPL--------PSTTSSIVCSPAS------ --------------------------------------------------SSWPSTQPLA STTSSTSSYTTGSP------------ATRS------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------S---------------------KPFL- S---------LVKSLSTD-VEPRE------STTPVPVPAPA---------SAPQ------ ------P-K-----RHR-HLMKTLVKSLSTDT-AHPEQE--------------------- -----------SPS------HRQTD--SR-LNLHLFKPFAQQR----------VT-VPPG --------GD-SKTAPSSPITSP-DGR---TF-FKVQEVEARIEDTKRRLSEVMCEPLQL LSKIIGEEG---GSTT------------SAVAATAIGGGATVPG-----------Q---- GS----------SHRPKSLSTSATELSTLTTLN-GHLES---NSD-YCIKEEE-D-LEG- E----------------------------------------------------------- --------------------------------------------------------SP-- ------------------------------------------LEG--------------- ------------------------------------------------------------ T---LP-----------------RS----------------------------------- --------PSL------------------GLDRCFMSAL-ARQEDEEFCELYSEDF---- ----------------------------------------------------ELCTDTEA -DG--------------------------------------------------------- ----------------------E------------------------------------- ----------LADSTRLQRGSTA-CSEEATEGEE-------------------------- ----------------------------------------------------------DG EEE--------------------------------------------------------- --E--------------------------------------------------------- ---------------------------------------------------------EED DDYDKS--------------TGVPQNGLILLVSIVYGYFVLPLPTYVGGVLLGVAAGFML AILVLWLSAP---------------------------------R---------------- -------------RVPA-WGP----------TCFS---------RSR-------RERW-- ----------------SGVP-----------------LDIKEPSIYKGWMNEIHSYDPES YHATLTHSVYVRLEGSVLRLSKPNRNIPRRASFSE--PKPDVTYISQKIYDLTSSKIYLV PHSLARKRVWNKKYPICIELAKQDDFMSK------------------------------- -AQGE------------------------------------------------------- ----------R-------------------------------PDPAEEK----------- ------------------------------------------------------------ --------------------------------TPAPVE---------KSEGTAGTEDNRR PSSDP------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ --------------VLFLFGRTGREKEEWFRRMLLASR---------------------- -----------------------LKAEI-KKPPG-------------------------- -----LPSPF---------------------VPSHGRSSSQ------------------- ------------------S--GALSH----------------SRS------------SSR GSLDDLLQSQSQTRQKDP----------GG-G---------------------------- ---AKQK-VLDYNVYMAKYI---------------S-----QS----------------- -------------------SGSP----TA------SPA---------------------- ------------------------------------------------------------ ---------HSTDSSPRTVKK---F---------P-HG---------------------- ----------LS--SEAG-----SEAWVNALLGRIFWDFLREKYWADVVSKKIQMKLSKI RLPYFMNELTLTELDMGMAIPKILRSSKPSVDHQGLWFDLEISYNGSFLMTLETKMNLAR LGKE--GEGL--GEQGKEG--PRTYCLADSDEESSSAGSSDEEDPAE------------- --------D-----PEIS----GVEGYVGGHRPSKIMRFVDKIAKSKYFQKATETEFIKK KMEEVSNTPLLLTVEVQECRGTLAVNIPPPPTDRIWYGFRSPPHLELKARPKLGEREVTL AHVTDWIEKKLDQEFQ-------------------------------------------- ------------------------------------------------------------ --------------------------------------------------KIFVMPNMDD VWLPIMHSAMDTRSNL-------------------------------------------- ------------------------------------------------------------ ---------------NLVT--VISDAVKS---E-----ATLDLEDPA------------- ---------------EEL---------- >ENSPNAP00000022202 ----------------------------M------------------------------- ------------------------------------------------------------ -------------------------------------------TSQG------------- ----------------------------GSNGDTPSPPP--------------SSSLLRP --------PAGPK-----------------------LQVQRSLSRDTITIHFSAQGK-EE EEED-----------------------E-E--LY-------------------------- ------------------------------------------------------------ ------R-----------------LAVSSS-----GQDG--------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------DDQGIVT--------------AMEASEELL------------------ ----------------------------------FEGAG--------------------- ------------------------------------------------------------ ---------------MGTDSGVLPVTSAMVSSLPVTHTLSSALAIQPPPSSLPSST---- -------------------------SS--------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------VCSPAS------ --------------------------------------------------SSWP------ -----------------------------SEHQRPQPPP--------------------- ------------------------------------------------------------ -------------------------------------------------LATYSSSST-- ---------------------------------------------------------SSP AK-------S-------------------SAVHS---------------------KPFL- S---------LVKSLSTE-VEPREGSVSTH---------------------APQ------ ------P-M-----RHR-HLMKTLVKSLSTDT-ARPEQE--------------------- -----------IPS------HRLPD--SR-LNLHLFKPFTQPR----------VT-APPG --------GD-SKTAPSSPLTSP-DGR---SF-FKVQEVEARIEDTKRRLSEVMCEPLQL LSKIIGEEG---GSTTTSTSTTGMTTGI-------------------------------- -------------HRPKSLSTSATELSNLATLN-GHLES---NND-YCIKEEE-D-VEG- D----------------------------------------------------------- --------------------------------------------------------SP-- ------------------------------------------LAGAD----PL------- -----------------------------------------------------------P A---LP-----------------RS----------------------------------- --------PSL------------------GLDRCFMSAL-ARQEDEEFYELYSEDF---- ----------------------------------------------------ELCTDTEA -DA--------------------------------------------------------- ----------------------E------------------------------------- ----------PADSGLLLRGSTA-GSEEPTEGEE-------------------------- ----------------------------------------------------------EG EEE--------------------------------------------------------- --E--------------------------------------------------------- ---------------------------------------------------------E-- ---DEP--------------LGVPHNGLILLISIVYGYFVLPLPTYVGGVLLGVAAGFML AILVLWLSAP---------------------------------R---------------- -------------R-SS-WGP-----------CFS---------RCR-------RERW-- ----------------TVVP-----------------LDIKEPGIYKGWMNEIHSYDPEM YHATLTHSVYVRLEGSVLRLSKPNRNIPRRASFNE--TKPDVTYISQKIYDLTNSKIYLV PHSLARKRVWNKKYPICIELAKQDDFMSK------------------------------- -AQGD------------------------------------------------------- ----------R-------------------------------TEAAEEK----------- ------------------------------------------------------------ --------------------------------PPAVVE---------KAEGLGGGEESKR SSADP------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ --------------VLYLFGRTGREKEEWFRRMLLASR---------------------- -----------------------LKAEM-KKPPS-------------------------- -----LPASF---------------------LPSHGRGSSQ------------------- ------------------S--GALSH----------------SRS------------SSR GSLDDLLQSQS--RQKDV----------GT-G---------------------------- ---AKQK-DLDYNVYMAKYI---------------S-----HF----------------- -------------------SGSP----AA------SPV---------------------- ------------------------------------------------------------ ---------HSTDSSPRTVKK---F---------P-DG---------------------- ----------LS--AEAA-----SEAWVNALLGRIFWDFLREKYWADVVSKKIQMKLSKI RLPYFMNELTLTELDMGMAIPKILRSSKPSVDHQGLWFDLEISYNGSFLMTLETKMNLAR LGKE--GEGL--GEQGKEGPRPRTYCLADSDEESSSAGSSDEEDPAE------------- --------V-----PEVP----GVEGYVGGHRPSKIMRFVDKIAKSKYFQKATETEFIKK KMEEVSNTPLLLTVEVQECRGTLAVNIPPPPTDRIWYGFRRPPHLELKARPKLGEREVTF AHVTDWIEKKLDQEFQ-------------------------------------------- ------------------------------------------------------------ --------------------------------------------------KIFVMPNMDD VWLPIMHSAMDTRSSA-------------------------------------------- ------------------------------------------------------------ ---------------NLVT--VTTDALKG---V-----ETLDLEDAV------------- ---------------DDL---------- >ENSIPUP00000016253 ----------------------------M------------------------------- ------------------------------------------------------------ -------------------------------------------TSQG------------- ----------------------------GSNVDTP-----SHLPSS-------SSSFLRP --------SSGPK-----------------------LHVQRSLSRDTITIHFSSQGK-EE EEED-----------------------E-E--LY-------------------------- ------------------------------------------------------------ ------K-----------------LAVSTS-----ALDG--------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------DDQGIVT--------------ALEASEELL------------------ ----------------------------------FEGTG--------------------- ------------------------------------------------------------ ---------------TGLGSGVPPVSSAM--------------------------TSSSS VVTHTQSSALAIQPLFTSLG----SSS--------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------TCSPSS------ --------------------------------------------------SSWP------ -----------------------------SEHWTQLPPP--------------------- ------------------------------------------------------------ --------------------------------------------------ATYSASST-- ---------------------------------------------------------SSP VK-------A-------------------TAVHS---------------------RPFL- S---------LVRSLSTE-VEPREGVPS------------A---------TAPQ------ ------P-M-----RHR-HLMKTLVKSLSTDT-ARLEQE--------------------- -----------TPA------HRPPD--SR-RNLHLFKPFTQPR----------VT-ATAS --------GD-SKTAPSSPVASP-DGR---SF-FKVQEVEARIEDTKRRLSEVMCEPLQL LSKIIGEEG---GSTA-------------------------------------------- -SGGSTTGTAWGAQHPKSLSSSTSELCSLTALN-GHLES---KTD-YCIKEED-D-FEG- D----------------------------------------------------------- --------------------------------------------------------SP-- ------------------------------------------------------------ ------------------------------------------------------------ -----PGIA---------TNVIFKS----------------------------------- --------PSL------------------GLDRCFMSAL-ARQEDEEFCELYSEDF---- ----------------------------------------------------ELCTDTEA -DG--------------------------------------------------------- ----------------------D------------------------------------- ----------LGNSAHLQLGSTA-CSEEPTEGGE-------------------------- ----------------------------------------------------------EE EEE--------------------------------------------------------- --E--------------------------------------------------------- ---------------------------------------------------------E-- ---EVP--------------PTIPHNGLILLISVVYGYFVLPLPTYIGGVLLGVAAGFML AILVVWLSAP---------------------------------R---------------- -------------S-SS-WGP-----------RFR---------RCK-------RERW-- ----------------NGVP-----------------LDIKEPIIYKGWMNEIYSYDPEA YHATLTHSVYVRLEGSVLRLSKPNRNVPRRATFNE--PKPDITYISQKIYDLTNSKIYLV PHSLARKRVWNKKYPICIELAKQDDFMSKGDQ--------------------TESEDEKV LASGE------------------------------------------------------- ----------R------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------TEGVVGSEDTKR P-TDP------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ --------------ILYLFGRTGREKEEWFRRMLLASR---------------------- -----------------------LKAEI-RKPSG-------------------------- -----LLASC---------------------LPSYSSGSSQ------------------- ------------------A--GALSH----------------SCS------------SSQ GSLDDVIQPKP--RQKDV------------------------------------------ ----KQK-VLDYNVYMAKYI---------------S-----HS----------------- -------------------SGSP----NP------SPL---------------------- ------------------------------------------------------------ ---------HSTDSSPRSATK---F---------P-AG---------------------- ----------PG--TEAE-----SEAWVNALLGRIFWDFLREKYWADMVSKKIQMKLSKI RLPYFMNELTLTELDMGMAIPKILKASKPSVDHQGLWFDLEISYTGSFLMTLETKMNLAR LGKE--GESC--GEQGKEG--PRTYCLADSDEESSSAGSSDEEDPTE------------- --------V-----PEMP----GTEGFVGGHRPSKIMRFVDKIAKSKYFQKATETEFIKK KMEEMSNTPLLLTVEVQECQGVLAINIPPPPTDRIWYGFRRPPHLELKARPKLGEREVTF AHVTDWIEKKLDQEFQ-------------------------------------------- ------------------------------------------------------------ --------------------------------------------------KIFVMPNMDD VWLPIMHSAMDTRSSM-------------------------------------------- ------------------------------------------------------------ ---------------NLAT--VTTDALKD---A-----APLDLEQTA------------- ---------------DDF---------- >ENSDARP00000098400 ----------------------------M------------------------------- ------------------------------------------------------------ -------------------------------------------TSKG------------- ----------------------------GSHEDTLSPPSSSSS---------------RS --------SAARK-----------------------VQVQRSLSRDTITIHFSAKGN-EE EEEE-----------------------E-E--LY-------------------------- ------------------------------------------------------------ ------R-----------------LAVSPS-----GLET--------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------EDQSIVT--------------AQEASEELLSEG------------LGA DMVTGMSCQTQSSALAIQHPSVSLGCTATSNLASF------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------------SWP------ -----------------------------SEQRSTPPLP--------------------- ------------------------------------------------------------ --------------------------------------------------STHSASSS-- ---------------------------------------------------------SSP AK----------------------------ALPS---------------------KPFL- S---------LVKSLSSE-VESRE--------------APT---------VAPQ------ ------S-V-----RHR-HLMKTLVKSLSTDT-ARPEQEP-------------S------ ----------STP--------RPPD--SR-LNLHLFKPFTQTR----------V----PG G---S---GD-SKTAPSSPLTSP-DSR---SF-FKVQEVEARIEDTKRRLSEVMCEPLQL LSKIIGEE----------------------------------PGGVSANSSSSTAA---- GV----------SYRSRNLSSSASELSNLSALN-GHSES---NNN-YCIKEEE-D-LEN- E----------------------------------------------------------- --------------------------------------------------------SP-- ------------------------------------------VES--------------- ------------------------------------------------------------ ATVELP---------------LHRS----------------------------------- --------PSL------------------GLDRCFMSTL-ARQEDEEFCELYTEDF---- ----------------------------------------------------EFCTDMEL -DG--------------------------------------------------------- ----------------------E------------------------------------- ----------ETHISLVQRGSTAGCSEEPTEGGE-------------------------- ------------------------------------------------------------ EEE--------------------------------------------------------- --E--------------------------------------------------------- ---------------------------------------------------------E-- ---DEP--------------PGVPHNGLILLISIVYGYFVLPLPSYVCWVLMGVAAGFML AILVVWLSAR---------------------------------Q---------------- -------------K-TS-WGR-----------HGS---------LSR-------RHQW-- ----------------NRVP-----------------LDIKEPAIYKGWMNEICSYDPET YHATLTHSVYVRLEGSVLRLSKPNRNIPRRATFSE--LKPDVTYVSQKIYDLTNSKVYLV PNNLARKRVWNKKYPICIELAKQDDFLAK------------------------------- -AQGE------------------------------------------------------- ----------K-------------------------------TEVMEEKT---------- ------------------------------------------------------------ -------------LTAGDKAEIVSTSEEPKRLH--------------------------- --TEP------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ --------------VLYLFGRTGRDKEEWFRRMLFASK---------------------- -----------------------LKSEA-KKPSG-------------------------- -----LPTS--------------------------------------------------- ----------------------CLSH----------------SRS------------SSR GSLDEVLQSHP--KQKDL----------GA-S---------------------------- ---VKQK-VLEYNVYMAKYV---------------S-----QS----------------- -------------------VGSP----TT------SPV---------------------- ------------------------------------------------------------ ---------QSAGSSPGTTKK---F---------P-ES---------------------- ----------CE--QSAE-----TEAWINALLGRMFWDFLREKYWADVVSKKIQKKLSKI RLPYFMNELTLTELDMGISIPKILSSSKPSVDHKGLWFDLEISYNGSFLMTLETKMNLTR LGKE--GEGL--GEQGKEG--PRTYFLADSDEESSSAGSSDEEDTVE------------- --------V-----PEIP----GVEGFVGGHKPSKIMRFVDKIAKSKYFQKATETEFIKK KIEEVSNTPLLLTVEVQECQGTLAVNIPPPPTDRIWYGFRRPPRLELKARPKLGEREVTF AHVTDWIEKKLDQEFQ-------------------------------------------- ------------------------------------------------------------ --------------------------------------------------KIFVMPNMDD VWLPIMHSAMDTRSN--------------------------------------------- ------------------------------------------------------------ ----------------------------------------------ASALRDE------- ---ETLDPKES--L-EDM---------- >ENSCHAP00000027976 ----------------------------M------------------------------- ------------------------------------------------------------ -------------------------------------------SWPGGGGEGGGGGSTGD RAEPDPTSS------------------------SP-P----------------------- -----RASGPGPR-----------------------LQVQRSLSRDTITIHFSAQGR-EE DEDE-----------------------E-E--LY-------------------------- ------------------------------------------------------------ ------G----------------------------------------------------- -------------------------------------------------------SPL-- ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------I--------------------------- --------------QSVVT--------------AVEASEEF------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------NSHAGAAVGTTP------------------------------RT---- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -HTP---------------------AVAILQP------------------SPSA------ -------------------------------------SSF------SSISSSWP------ -----------------------------LD--------------------APQAP---- ------------------------------------------------------------ ----------------------------APAPASTHPL-----------------SSS-- ---------------------------------------------------------SSP VRT--PQAPA-------------------SALP---------------------SKPFL- S---------LVKSLSSD-VEPREPREP----------PTSSVAGVAPLLVRPP------ ------H-LQAQSQHRR-HLMKTLVKSLSTDT-ARPDLD--------------------- ---------------------------SR-LNRHLFNPFAQSRPGALHSMGTGAS-TCR- --------GG-SVTAPSSPLASPLDGRSSSSF-MKVTEVEARIEDTRRRLSEVMSEPLYL LSKFMGEEG---GIGSA--------------------------------------GSGVT GA----------GQRPRTLSSSACELTSLAGLN-GHPET-----S-YSIKEEEGD-LED- -------------------KNEE------------------------------------- -------KRDRSDITVPSPGRVASWS-----------------------------PPP-- ------------------------------------------------------------ ------------------------------------------------------------ ----------------------PRS----------------------------------- --------PSL------------------GLDRCTMSAL-VRQEDEEFCELYSEDF---- ----------------------------------------------------EQDEETET ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----EGWHAAASQRRQSSLTGAYSQDDTDDEDDD---------------------DDDDQ E--------------------------------------------------------E-- ---DQA--------------PGVPHNSLLLLISVVYGYFVLPLPPYVEAVLMGMAAGFML AILVVWLSVP---------------------------------R---------------- -------------H-TS-----LTCSSLPR--------------RRR-------GERW-- ----------------NLTP-----------------LDIKEPGVFKGWMNEIVSYDPET YHATLTHSVFVRLEGSTLRLSKPSRNIPRRAAFNE--PKPDVSYISQKIYDLSDSKISLV PQSLARKRVWNKKYPICIELGPQEDFMAR------------------------------- -AQED------------------------------------------------------- ----------R-------------------------------PETGEER----------- ------------------------------------------------------------ ------------------------------------------------------------ P----------------------------------------------------------- ---------AS--GGERPEGGSSRSEEGMVRRQSG------------------------- -----------------------------------DL----------------------- --------------TLYLFGRTGREKEEWFRRILFASR---------------------- -----------------------LKPEA-RRPASIAG----------------------- ------------------------------------------------------------ ------------------V--YLPSH----------GGL-SHSRS------------SSR GSLEEALQSQP--RTKEL----------PA-G---------------------------- ---VKQN-VLDYSVYMAQYV---------------S-----PG----------------- ---------------ATS--------------RPTSPS---------------------- ------------------------------------------------------------ ---------PSAPSSPGASKQ---V---------L-DN---------------------- ----------QG--EECE-----SEAWANALIGRIFWDFLGEKYWADMVSKKIQMKLSKI RLPYFMNELTLTELDMGVTIPKILKASKPYVDHQGLWFDLEISYHGSFLMTLETKMNLAR LGKE--GEGL--GEQGKEG--PRMYCLADSDEESSSAGSSDEEEPQE------------- --------V-FTDKALPP----GAESYVGGHRPSKIIRFMDKIAKSKYFQKATETEFIKK KMEEVSNTPLLLTVEVQEFKGTLAVNIPPPPTDRIWYGFRSPPHLELKARPKLGEREVTF AHVTDWIEKKLDQEFQ-------------------------------------------- ------------------------------------------------------------ --------------------------------------------------KIFVMPNMDD IWLPIMHSAMDPRSNT-------------------------------------------- ------------------------------------------------------------ ---------------SLLA--VMTDALKE---T-----EFS------------------- -----CDSELS-TQ-SDM---------- >ENSSFOP00015004763 ----------------------------M------------------------------- ------------------------------------------------------------ -------------------------------------------SSRS------------- ------------------QSGSRVERAGGRHAA---P--------------------TRT --------PSAPM-----------------------LQVQRSRSRETITIHFSALGV-ED ELEE-----------------------Q-E--LY-------------------------- ------------------------------------------------------------ ------GPTSP------------------------------------------------- ------------------------------------------------------------ -------------------------------PDSPLPRLECEGYKVAM------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------AVEASEELL------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------SEEDAAVSRALPSGAVM-------- ----------------------P----------------------------PTSN----- --------------------------------------------------LSWQ------ ------------------------------------------------------------ -------------------------------------------SGQK------------- ------------------------------------------------------------ ------------STGTAPTLVG-----------------------------------SSP PKPVAPT-----------------------------------------------PKPFL- S---------LVKSLSVE-AEGREVP-------------------------APP------ ------S-P----KLHC-HLVKSLVKSLSTDA-SRPEAE--------------------- -----------PAA------HRPPD--SR-LSLHLFKPFGPSE---------------PV I------AGD-SKTAPSSPLSSP-DER---PF-FKVPEVEARIEDTRRRLSEAMSEPLQL LSKIMGDES---S-GSS--------------------------------------G---- AA----------PCRPKALSSSTSDLTSLDSMN-GHLES--ISNS-NSIQEEETS-WAG- E----------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------ARTL------------------VLDRCSMSAL-VRQQDEEFYELYSE------ --------------RRGLVSCTELLKEKAQDVDS-------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------GSREPGHGEQE----------------DEEE----- ----------------------------------------------------------ED EEEE-------------------------------------------------------- ------------------------------------------------------------ ---------------------------------------------------------E-- ---EEA----EQEVGRGEMVPGIPHKSLLALAALVYSYLVLPLPAYLGGVLLGVAAGFLL ATFMLWLAAP---------------------------------R---------------- -------------R--------------P---RCC---------RFR-------AELW-- ----------------SVSH-----------------LAVQEPGIFKGWMNEIYSYDPEM YHATLTHSVFVRLEGSVLRLSKPSRSIARRATFNE--PKPEVTFVSQKIYDLTDSKVYLM PQNLARKRLWNKKYPICVELAKQEHFMST------------------------------- -AQAD------------------------------------------------------- ----------Q-------------------------------SEAG-------------- ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------GVGVKDAC-------- -------------GG----------EEAL-----G------------------------- ----------PSFGSQEPGCALDAKDHK-------------------------------- --------------TLYLFGRTGREKEEWFRRMSVASR---------------------- -----------------------FKAES-KKLSG-------------------------- -----LPASF---------------------LPAQSCTNSQ------------------- -------SGGL-------------TH----------------SRS------------SSR GSLDEILASQP--RQKEL----------AG-G---------------------------- ---LRQKALLDYTTYMAQYV---------------R-----TQ----------------- ---------------------QE----SSSQ----SPT---------------------- ------------------------------------------------------------ ---------QSPEGSPGVSRK---L---------P-RS---------------------- ----------PE--EEVE-----PEAWVNALLGRIFWDFLGEKYWADMVSKKIQMKLSKI RLPYFMNELTLTELDMGVAIPKILQASKLTVDHQGLWFDLEISYNGSFLMTLETKMNLAR LGKE--GEGLRLGEPGKDG--PRTYCLADSDEESSSAGSSDEEDQAE------------- --------I-FADKNLQP----GAEGYVGGHRPSKIMRFVDKIAKSKYFQKATETEFIKK KMEEVSNTPLLLTVEVQELRGTLAVNIPPPPTDRIWYGFRSPPHLSLKARPKLGEREVTL VHVTDWIEKKLDQEFQ-------------------------------------------- ------------------------------------------------------------ --------------------------------------------------KIFVMPNMDD IWLPIMHSAMDTRSDV-------------------------------------------- ------------------------------------------------------------ ---------------SLLS--MTLEAAKE---S-----DSM------------------- ---------EV-EV-------PTSCDD-