>ENSDORP00000015791 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------M-----------SQQIH----------------------- ---------A---------------GSSVS--------------------HTS------- ------FLDLWREKNDQLVRQAKQVV-QD------------------------------- ------------------------------------------TQLS-------------- ------------------------LRRQ-------------------------------- --------QLAQD---------------------------------------------TL EGLRKLLWGL-------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------Q----------------------------------G--- -------------------------------------------LPATVPVLP-------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------LELTVTCNFIILRVS- -LAQGFTEDLAQDIQRSLKR----------------------------------VLETQE -HLE---PRLQQSLREL---------------WESV------------------------ ------------------------------------------------------------ ---------LHASSLLPELLSALHLLAG-------------------------------- ------------------------------------------------------------ ---------------------------LQA------------------------------ ---------------------------ALWLSTDHLGDLAIL------------------ ---------------------------------------------------------LQT LNG----------------------SQ--------G---RTS------------------ --EDLLL-----LFKSWNPPVEK------------------------------------- -----------------------------------------------------SDGPLTL QNAQSLRAVLL-------------------------------------------T----- ---------------AFAYQQGL--------QELITGNL----------------PRALR NLHEAASGLCTRPV------------------------------LVQVYTALGTCLRKME ------------------------------------------------------------ ------NPQRAL-----LYLIEALKVGTDCSLPLLE------------------------ ---------------------------------------------------------ASR LYRQLGDT----------SAELESLELLVEALSVI----RS---SKS------------- --------PQLL----------------------------------IEAEL--------- ------------------------------------------------------------ -------LLPQPDQASPLHCVT-------------------------------------- -------------------------------PSQAKHLL--------------------- --------------ASRCLQI--------------------------------------- ------------------------------------------------------------ -----GREED----------AAEHY----------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ LDL--------------------------------------------------------- ------------------------------------------------------------ -----LALLL-DGS---------------------------------------------- -------------------------------------------------------EPR-- ------------------------------------------------------------ ---------------------------------------------F------S------- -----LLPCPP-GPCVPEVFLETAAALIQAGRAQDA------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ FTVCE------------------------------------------------------- ---------------------------------------------------------ELL SRTSSL-----LPKMSQLR---------------------------EGARK--------- ------------------------------------------------------------ ---------------------------------------------------------GS- ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------K------------------- ------------------------------------------------------------ -----------ELPY--------------CQLWVSA------------------------ ------------------------------------------------------------ ------------------------------------------------------THLLQG QAWVHL--KAPKEAVSEFSRCLELLFCT-------------------------------- --------TPE-DK---------------EQ----------------------------- -----------------GF--------------------NYEQGCS-------------- ----------------------SEA------------------A---------------- -----------------------LQQL--------------------------------- --------------------------------------------RVAALISRGLVWVAS- ---------------------------------------------------------NQD TKALKDFLLSV------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------QIFP------------------------ ----------------------------------------GSRDASYY------------ ---------------------------------------LLQTLRRL------------- ----------------------------------------------------DRKDDATA L---------------------W------------------------QRLEAQT-----E L-T----QKEAT----------R-------------S----------------------- ------------------LPLYLETY---------------------------------- -----------------------------------------------------LSWIHPT DCETFLEE----------------------------------------FRTSL------- ------------------------------------------------------------ -------LEPHD-Q------------------------ >ENSAMEP00000016351 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------A-----------SHQT------------------------ ----------------------PL-GSSVP--------------------HAS------- ------CLDLWREKNDQLVRQVK-VA-QD------------------------------- ------------------------------------------SRLS-------------- ------------------------LRRQ-------------------------------- --------QLAQD---------------------------------------------AL EGFRGLLHSL-------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------R----------------------------------G--- -------------------------------------------LPAAVPVLP-------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------LELTVTCNFITLRAS- -LAQGFTEDQAQDIQQGLER----------------------------------VLETQE -QLG---PRLECGLRGL---------------WDSI------------------------ ------------------------------------------------------------ ---------FGYSSLLLELLPALHLLAG-------------------------------- ------------------------------------------------------------ ---------------------------LQA------------------------------ ---------------------------ALWLSTDSLGDLTFL------------------ ---------------------------------------------------------LQT LNG----------------------NQ--------S---EAS------------------ --ENLLL-----LLKTWSPPAEE------------------------------------- -----------------------------------------------------SDAPLTL QNARGLRDVLL-------------------------------------------T----- ---------------ASAYRQGL--------QELITGSL----------------PTALS SLQEAASGLCPRPV------------------------------LVQVYTALGTCLRKMG ------------------------------------------------------------ ------NPQRAL-----LYLVAALKGGSTWGPPLLE------------------------ ---------------------------------------------------------ASR LYRQLGNT----------AAELESLELLVEALNVT----HS---SEA------------- --------PQLL----------------------------------IEVEL--------- ------------------------------------------------------------ -------LLPRPHPASPLHCGT-------------------------------------- -------------------------------QSQAKYLL--------------------- --------------ASRCLEV--------------------------------------- ------------------------------------------------------------ -----GRAED----------AAEHY----------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ LDL--------------------------------------------------------- ------------------------------------------------------------ -----LALML-DGS---------------------------------------------- -------------------------------------------------------EPK-- ------------------------------------------------------------ ---------------------------------------------F------F------- -----PPPPPP-GPCIPEVFLEAAAALIQAGRAQDA------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ LTVCE------------------------------------------------------- ---------------------------------------------------------ELL SRTSSL-----LPKMPQLW---------------------------EDARK--------- ------------------------------------------------------------ ---------------------------------------------------------GI- ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------K------------------- ------------------------------------------------------------ -----------ESPH--------------CPSWVSA------------------------ ------------------------------------------------------------ ------------------------------------------------------TYLLQG QAWVQL--GAQKEAISEFSRCLELLFRA-------------------------------- --------TPK-DK---------------EQ----------------------------- -----------------GP--------AS----------SGEKGCV-------------- ----------------------SDV------------------A---------------- -----------------------LQQL--------------------------------- --------------------------------------------RAAALISRGLQWVAS- ---------------------------------------------------------GQD TKALQDFLLSV------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------QMCPG-----------GA---------- ---------------------------------------AGHQDASFH------------ ---------------------------------------LLQTLRRM------------- ----------------------------------------------------DRRDEATA L---------------------W------------------------WRLEAQT-----K L-P----QENAA----------W-------------S----------------------- ------------------LPLYLETY---------------------------------- -----------------------------------------------------LGWICFP DRETLLEE----------------------------------------FQTSL------- ------------------------------------------------------------ -------PEPCD-L------------------------ >ENSUAMP00000031717 M----------------------------------------------------------- ------------------------------------------------------------ ---------EEAGVGAATGSRRESISPVKGESPLLGPRGEQRSCGGVRKRRDPSPLGWGP RRGRAYPATAPSRCPGPA------------------------------------------ -----------------SATM-----------SHQT------------------------ ----------------------PL-GSSVP--------------------HAS------- ------CLDLWREKNDQLVRQAK-VA-QD------------------------------- ------------------------------------------SRLS-------------- ------------------------LRRQ-------------------------------- --------QLAQD---------------------------------------------AL EGFRGLLHSL-------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------R----------------------------------G--- -------------------------------------------LPAAVPVLP-------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------LELTVTCNFITLRAS- -LAQGFTEDQAQDIQQGLER----------------------------------VLETQE -QLG---PRLECGLRGL---------------WDSI------------------------ ------------------------------------------------------------ ---------LGYSSLLLELLPALHLLAG-------------------------------- ------------------------------------------------------------ ---------------------------LQA------------------------------ ---------------------------ALWLSTDSLGDLTFL------------------ ---------------------------------------------------------LQT LNG----------------------NQ--------S---EAS------------------ --ENLLL-----LLKTWSPPAEE------------------------------------- -----------------------------------------------------SDAPLTL QDARGLRDVLL-------------------------------------------T----- ---------------ASAYRQGL--------QELITGSL----------------PRALS SLQEAASGLCPRPV------------------------------LVQVYTALGTCLRKMG ------------------------------------------------------------ ------NPQRAL-----LYLVAALKGGSTWGPPLLE------------------------ ---------------------------------------------------------ASR LYRQLGNT----------AAELESLELLVEALNVT----HS---SEA------------- --------PQLL----------------------------------IEVEL--------- ------------------------------------------------------------ -------LLPRPHPASPLHCGT-------------------------------------- -------------------------------QSQAKYLL--------------------- --------------ASRCLEV--------------------------------------- ------------------------------------------------------------ -----GRAED----------AAEHY----------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ LDL--------------------------------------------------------- ------------------------------------------------------------ -----LALML-DGS---------------------------------------------- -------------------------------------------------------EPK-- ------------------------------------------------------------ ---------------------------------------------F------F------- -----PPPPPP-GPCIPEVFLEAAAALIQAGRAQDA------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ LTVCE------------------------------------------------------- ---------------------------------------------------------ELL SRTSSL-----LPKMPQLW---------------------------EDARK--------- ------------------------------------------------------------ ---------------------------------------------------------GT- ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------K------------------- ------------------------------------------------------------ -----------ESPH--------------CPSWVSA------------------------ ------------------------------------------------------------ ------------------------------------------------------TYLLQG QAWVQL--GAQKEAISEFSRCLELLFRA-------------------------------- --------TPK-DK---------------EQ----------------------------- -----------------GP--------AS----------SGKKGCV-------------- ----------------------SDV------------------A---------------- -----------------------LQQL--------------------------------- --------------------------------------------RAAALISRGLQWVAS- ---------------------------------------------------------GQD TKALQDFLLSV------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------QMCP------------------------ ----------------------------------------GHQDASFH------------ ---------------------------------------LLQTLRRM------------- ----------------------------------------------------DRRDEATA L---------------------W------------------------WRLEAQT-----K L-P----QENAA----------W-------------S----------------------- ------------------LPLYLETY---------------------------------- -----------------------------------------------------LGWICFP DRETLLEE----------------------------------------FQTSL------- ------------------------------------------------------------ -------PEPCD-L------------------------ >ENSUMAP00000008385 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------M-----------SHQT------------------------ ----------------------PL-GSSVP--------------------HAS------- ------CLDLWREKNDQLVRQAK-VA-QD------------------------------- ------------------------------------------SRLS-------------- ------------------------LRRQ-------------------------------- --------QLAQD---------------------------------------------AL EGFRGLLHSL-------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------R----------------------------------G--- -------------------------------------------LPAAVPVLP-------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------LELTVTCNFITLRAS- -LAQGFTEDQAQDIQQGLER----------------------------------VLETQE -QLG---PRLECGLRGL---------------WDSI------------------------ ------------------------------------------------------------ ---------LGYSSLLLELLPALHLLAG-------------------------------- ------------------------------------------------------------ ---------------------------LQA------------------------------ ---------------------------ALWLSTDSLGDLTFL------------------ ---------------------------------------------------------LQT LNG----------------------NQ--------S---EAS------------------ --ENLLL-----LLKTWSPPAEE------------------------------------- -----------------------------------------------------SDAPLTL QDARGLRDVLL-------------------------------------------T----- ---------------ASAYRQGL--------QELITGSL----------------PRALS SLQEAASGLCPRPV------------------------------LAQVYTALGTCLRKMG ------------------------------------------------------------ ------NPQRAL-----LYLVAALKGGSTWGPPLLE------------------------ ---------------------------------------------------------ASR LYRQLGNT----------AAELESLELLVEALNVT----HS---SEA------------- --------PQLL----------------------------------IEVEL--------- ------------------------------------------------------------ -------LLPRPHPASPLHCGT-------------------------------------- -------------------------------QSQAKYLL--------------------- --------------ASRCLEV--------------------------------------- ------------------------------------------------------------ -----GRAED----------AAEHY----------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ LDL--------------------------------------------------------- ------------------------------------------------------------ -----LALML-DGS---------------------------------------------- -------------------------------------------------------EPK-- ------------------------------------------------------------ ---------------------------------------------F------F------- -----PPPPPP-GPCIPEVFLEAAAALIQAGRAQDA------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ LTVCE------------------------------------------------------- ---------------------------------------------------------ELL SRTSSL-----LPKMPQLW---------------------------EDARK--------- ------------------------------------------------------------ ---------------------------------------------------------GT- ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------K------------------- ------------------------------------------------------------ -----------ESPH--------------CPSWVSA------------------------ ------------------------------------------------------------ ------------------------------------------------------TYLLQG QAWVQL--GAQKEAISEFSRCLELLFRA-------------------------------- --------TPK-DK---------------EQ----------------------------- -----------------GP--------AS----------SGKKGCV-------------- ----------------------SDV------------------A---------------- -----------------------LQQL--------------------------------- --------------------------------------------RAAALISRGLQWVAS- ---------------------------------------------------------GQD TKALQDFLLSV------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------QMCP------------------------ ----------------------------------------GHQDASFH------------ ---------------------------------------LLQTLRRM------------- ----------------------------------------------------DRRDEATA L---------------------W------------------------WRLEAQT-----K L-P----QENAA----------W-------------S----------------------- ------------------LPLYLETY---------------------------------- -----------------------------------------------------LGWICFP DRETLLEE----------------------------------------FQTSL------- ------------------------------------------------------------ -------PEPCD-L------------------------ >ENSNVIP00000031193 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------M-----------SHQT------------------------ ----------------------PL-GTSVP--------------------HTS------- ------CLDLWREKNDQLVRQAK-VA-QD------------------------------- ------------------------------------------SGLS-------------- ------------------------LRRQ-------------------------------- --------QLAQD---------------------------------------------AL EGFRGLLHSL-------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------R----------------------------------G--- -------------------------------------------LPAAVPVLP-------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------LELTVTCNFITLKAS- -LAQGFTEDQAQDIQQGLERGVPQTRSTFVTFGLLQKEKSRDEVPTSAVCLSSTVLETQK -KLG---PRLECGLRGL---------------WDSV------------------------ ------------------------------------------------------------ ---------LHYSTLLLEVLPALHHLAG-------------------------------- ------------------------------------------------------------ ---------------------------LQA------------------------------ ---------------------------AIWLSTDCLGDLTFL------------------ ---------------------------------------------------------LQT LNG----------------------NQ--------S---EAS------------------ --ENLLL-----LLKTWSPPAEE------------------------------------- -----------------------------------------------------SDVPLTL QDARGLRDILL-------------------------------------------T----- ---------------ASAYRQGL--------QELITGSL----------------PRALS SLQEAASGLCSRPV------------------------------LVQVYTALGTCLRKMG ------------------------------------------------------------ ------NPQRAL-----LYLAAALKGGSTCGPPLLE------------------------ ---------------------------------------------------------ASR LYRQLGNT----------AAELESLELLVEALNVT----HS---FEA------------- --------PQLL----------------------------------IEVEL--------- ------------------------------------------------------------ -------LLPRPHPASPLHCGT-------------------------------------- -------------------------------QSQAKYLL--------------------- --------------ASRCLQV--------------------------------------- ------------------------------------------------------------ -----GRAED----------AAEHY----------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ LDL--------------------------------------------------------- ------------------------------------------------------------ -----LALVL-DGS---------------------------------------------- -------------------------------------------------------ESK-- ------------------------------------------------------------ ---------------------------------------------F------F------- -----PPPSPP-GPCMPEVFLEAAAALIQAGRAQDA------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ LTVCE------------------------------------------------------- ---------------------------------------------------------ELL SRTSSL-----LPKMPQLR---------------------------EDARK--------- ------------------------------------------------------------ ---------------------------------------------------------GT- ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------K------------------- ------------------------------------------------------------ -----------ESPH--------------CPSWVSA------------------------ ------------------------------------------------------------ ------------------------------------------------------TYLLQG QAWVQL--GAPKEAISEFSRCLELLFRT-------------------------------- --------TPK-DE---------------EQ----------------------------- -----------------GP--------AS----------NGEKECI-------------- ----------------------SDV------------------A---------------- -----------------------LQQL--------------------------------- --------------------------------------------RAAALISRGLQWVTI- ---------------------------------------------------------GQD TKALQDFLLSV------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------QMCP------------------------ ----------------------------------------GYQDASFH------------ ---------------------------------------LLQTLRRM------------- ----------------------------------------------------DRRHEATA L---------------------W------------------------WRLKAQT-----E L-P----QENAA----------W-------------S----------------------- ------------------LPLYLETY---------------------------------- -----------------------------------------------------LDWIHSP DRETLLEE----------------------------------------FQTSL------- ------------------------------------------------------------ -------PEPPD-L------------------------ >ENSMPUP00000004563 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------M-----------SHQN------------------------ ----------------------PL-GTSVP--------------------HTS------- ------CLDLWREKNDQLVRQAK-VA-QD------------------------------- ------------------------------------------SGLS-------------- ------------------------LRRQ-------------------------------- --------QLAQD---------------------------------------------SL EGFRGLLHSL-------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------R----------------------------------G--- -------------------------------------------LPAAVPVLP-------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------LELTVTCNFITLRAS- -LAQGFTEDQAQDIQQGLER----------------------------------VLETQK -KLG---PRLECGLRGL---------------WDSV------------------------ ------------------------------------------------------------ ---------LHYSTLLLEVLPALHHLAG-------------------------------- ------------------------------------------------------------ ---------------------------LQA------------------------------ ---------------------------AVWLSTDCLGDLTFL------------------ ---------------------------------------------------------LQT LNG----------------------NQ--------S---EAS------------------ --ENLLL-----LLKTWSPPAEE------------------------------------- -----------------------------------------------------SDAPLTL QDARGLRDILL-------------------------------------------T----- ---------------ASAYRQGL--------QELITGSL----------------PRALS SLQEAASGLCSRPV------------------------------LVQVYTALGTCLRKMG ------------------------------------------------------------ ------NPQRAL-----LYLAAALKGGSTCGPPLLE------------------------ ---------------------------------------------------------ASR LYRQLGNT----------AAELESLELLVEALNVT----HS---FEA------------- --------PQLL----------------------------------IEVEL--------- ------------------------------------------------------------ -------LLPRPHPASPLHCGT-------------------------------------- -------------------------------PSQAKYLL--------------------- --------------ASRCLQV--------------------------------------- ------------------------------------------------------------ -----GRAED----------AAEHY----------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ LDL--------------------------------------------------------- ------------------------------------------------------------ -----LALVL-DGS---------------------------------------------- -------------------------------------------------------ESK-- ------------------------------------------------------------ ---------------------------------------------F------F------- -----PPPSPP-GPCMPEVFLEAAAALIQAGRAQDA------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ LTVCE------------------------------------------------------- ---------------------------------------------------------ELL SRTSSL-----LPKMPQLR---------------------------EDARK--------- ------------------------------------------------------------ ---------------------------------------------------------GT- ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------K------------------- ------------------------------------------------------------ -----------ESPH--------------CPSWVSA------------------------ ------------------------------------------------------------ ------------------------------------------------------TYLLQG QAWVQL--GAPKEAISEFSRCLELLFRT-------------------------------- --------TPK-DE---------------EQ----------------------------- -----------------GP--------AS----------NREKGCI-------------- ----------------------SDV------------------A---------------- -----------------------LQQL--------------------------------- --------------------------------------------RAAALISRGLQWVAV- ---------------------------------------------------------DQD TKALQDFLLSV------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------QMCP------------------------ ----------------------------------------GNQDASFH------------ ---------------------------------------LLQTLRRM------------- ----------------------------------------------------DRRHEATA L---------------------W------------------------WRLKAQT-----E L-P----QENAA----------W-------------S----------------------- ------------------LPLYLETY---------------------------------- -----------------------------------------------------LDWIHSP DREALLEE----------------------------------------FQTSL------- ------------------------------------------------------------ -------PEPHE-L------------------------ >ENSVVUP00000036467 MVGPGKKLVLLTPHPGFFPLTWP------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------------HTS------- ------CLDLWREKNDQLVRQAK-VA-QD------------------------------- ------------------------------------------SRLY-------------- ------------------------VRRQ-------------------------------- --------QLAQD---------------------------------------------AL EGFRGLLHSL-------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------Q----------------------------------G--- -------------------------------------------LPAAVPVLP-------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------LELTVTCNFITLRAT- -LAQGFTEDQAQDIQKGLER----------------------------------VLETQE -QLG---PRLECGLRGL---------------WDSV------------------------ ------------------------------------------------------------ ---------LHYSSLLLELLPVLHHLAG-------------------------------- ------------------------------------------------------------ ---------------------------LQA------------------------------ ---------------------------ALWLSTDHLGDLTLL------------------ ---------------------------------------------------------LQT LNG----------------------KQ--------S---EAS------------------ --ENLLL-----LLKTWSPPPKE------------------------------------- -----------------------------------------------------SDAPLTL QDARGLRDVLL-------------------------------------------T----- ---------------AAAYRQGL--------QELITGSL----------------PRALS SLQEAASGLCSRPV------------------------------LVQVYTALGTCLHKMG ------------------------------------------------------------ ------NPQRAL-----LYLVAALKEGSTWGLPLLE------------------------ ---------------------------------------------------------ASR LYRQLGNT----------AAELESLEL--------------------Y----IDVL---- ----FSFSPQLL----------------------------------IEVEL--------- ------------------------------------------------------------ -------LLPQPHPGSPLHCGT-------------------------------------- -------------------------------QSQAKYLL--------------------- --------------ASRSLQV--------------------------------------- ------------------------------------------------------------ -----GRAED----------AAEHY----------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ LDL--------------------------------------------------------- ------------------------------------------------------------ -----LALLL-DDS---------------------------------------------- -------------------------------------------------------EPK-- ------------------------------------------------------------ ---------------------------------------------F------S------- -----PPPTHP-GPCMPEVFLEAAAALIQAGRAQDA------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ LTVCE------------------------------------------------------- ---------------------------------------------------------ELL SRTSSL-----LPKMPQLW---------------------------EDDKK--------- ------------------------------------------------------------ ---------------------------------------------------------GT- ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------K------------------- ------------------------------------------------------------ -----------KPPH--------------CPSWVSA------------------------ ------------------------------------------------------------ ------------------------------------------------------TYLLQG QAWVQL--GDQKEAISEFSRCLELLFRT-------------------------------- --------TPK-GK---------------EQ----------------------------- -----------------GP--------AS----------NGEQRCM-------------- ----------------------SDV------------------A---------------- -----------------------LPQL--------------------------------- --------------------------------------------RAAALISRGLRWVAS- ---------------------------------------------------------GQD TRALQDFLLGV------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------QMCP------------------------ ----------------------------------------GNQDASFH------------ ---------------------------------------LLQTLRRM------------- ----------------------------------------------------DRRDEATA L---------------------W------------------------WRLEAQT-----K L-P----QENAA----------W-------------S----------------------- ------------------LPLYLETC---------------------------------- -----------------------------------------------------LGWICYP DRETLLEE----------------------------------------FRTSL------- ------------------------------------------------------------ -------PEPCD-L------------------------ >ENSCAFP00020020465 M---------------------PCAGPPPAEGQSWADLEAWLRAEGWDTVSGTEIDCSRF RPARGTGKPNREKYNLPTQTHPHPLVRRRLPFRMESPHVSSSSFPRGLTLEDDQPQQRVL SAGPTRGEMEEAGVGAGTESPRESISPEKADSPLRGPSGEQKSRGRVRKRRDLSPLGWGP RRDRPYPSADPSRCPGPA------------------------------------------ -----------------SATI-----------SHQT------------------------ ----------------------PL-SSSGP--------------------HTS------- ------CLDLWREKNDQLVRQAK-VA-QD------------------------------- ------------------------------------------SRLY-------------- ------------------------VRRQ-------------------------------- --------QLAQD---------------------------------------------AL EGFRGLLHSL-------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------Q----------------------------------G--- -------------------------------------------LPAAVPVLP-------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------LELTVTCNFITLRAT- -LAQGFTEDQAQDIQKGLER----------------------------------VLETQE -QLG---PRLECGLRGL---------------WDSV------------------------ ------------------------------------------------------------ ---------FHYSSLLLELLPVLHHLAG-------------------------------- ------------------------------------------------------------ ---------------------------LQA------------------------------ ---------------------------ALWLSTDHLGDLTLL------------------ ---------------------------------------------------------LQT LNG----------------------KQ--------S---EAS------------------ --ENLLL-----LLKTWSPPPKE------------------------------------- -----------------------------------------------------SDAPLTL QDARGLRDVLL-------------------------------------------T----- ---------------ASAYRQGL--------QELITGSL----------------PRALS SLQEAASGLCSRPV------------------------------LVQVYTALGTCLHKMG ------------------------------------------------------------ ------NPQRAL-----LYLVAALKEGSTWGLPLLE------------------------ ---------------------------------------------------------ASR LYRQLGNT----------AAELESLELLVEALNVT----HS---SEA------------- --------PQLL----------------------------------IEVEL--------- ------------------------------------------------------------ -------LLPQPNPGSPLHCGT-------------------------------------- -------------------------------QSQAKYLL--------------------- --------------ASRCLQV--------------------------------------- ------------------------------------------------------------ -----GRAED----------AAEHY----------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ LDL--------------------------------------------------------- ------------------------------------------------------------ -----LALLL-SDS---------------------------------------------- -------------------------------------------------------EPK-- ------------------------------------------------------------ ---------------------------------------------F------S------- -----PPPTHP-GPCMPEVFLEAAAALIQAGRAQDA------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ LTVCE------------------------------------------------------- ---------------------------------------------------------ELL SRTSSL-----LPKMPQLW---------------------------EDDKK--------- ------------------------------------------------------------ ---------------------------------------------------------GT- ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------K------------------- ------------------------------------------------------------ -----------KSPH--------------CPSWVSA------------------------ ------------------------------------------------------------ ------------------------------------------------------TYLLQG QAWVQL--GAQKEAISEFSRCLELLFRT-------------------------------- --------TPK-DK---------------EQ----------------------------- -----------------GP--------AS----------NGEQGCM-------------- ----------------------SDV------------------A---------------- -----------------------LPQL--------------------------------- --------------------------------------------RAAALISRGLQWVAS- ---------------------------------------------------------GQD TRALQDFLLGV------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------QMCP------------------------ ----------------------------------------GNQDASFH------------ ---------------------------------------LLQTLRKM------------- ----------------------------------------------------DRRDEASA L---------------------W------------------------WRLEAQT-----K L-P----QENAA----------W-------------S----------------------- ------------------LPLYLETC---------------------------------- -----------------------------------------------------LGWICYP DRETLLEE----------------------------------------FRTSL------- ------------------------------------------------------------ -------PEPCD-L------------------------ >ENSCAFP00000002933 M---------------------PCAGPPPAEGQSWADLEAWLRAEGWDTVSGTEIDCSRF RPARGTGKPNREKYNLPTQTHPHPLVRRRLPFRMESPHVSSSSFPRGLTLEDDQPQQRVL SAGPTRGEMEEAGVGAGTESPRESISPEKADSPLRGPSGEQKSRGRVRKRRDLSPLGWEP RRDRPYPSADPSRCPGPA------------------------------------------ -----------------SATI-----------SHQT------------------------ ----------------------PL-SSSGP--------------------HTS------- ------CLDLWREKNDQLVRQAK-VA-QD------------------------------- ------------------------------------------SRLY-------------- ------------------------VRRQ-------------------------------- --------QLAQD---------------------------------------------AL EGFRGLLHSL-------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------Q----------------------------------G--- -------------------------------------------LPAAVPVLP-------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------LELTVTCNFITLRAT- -LAQGFTEDQAQDIQKGLER----------------------------------VLETQE -QLG---PRLECGLRGL---------------WDSV------------------------ ------------------------------------------------------------ ---------FHYSSLLLELLPVLHHLAG-------------------------------- ------------------------------------------------------------ ---------------------------LQA------------------------------ ---------------------------ALWLSTDHLGDLTLL------------------ ---------------------------------------------------------LQT LNG----------------------KQ--------S---EAS------------------ --ENLLL-----LLKTWSPPPKE------------------------------------- -----------------------------------------------------SDAPLTL QDARGLRDVLL-------------------------------------------T----- ---------------ASAYRQGL--------QELITGSL----------------PRALS SLQEAASGLCSRPV------------------------------LVQVYTALGTCLHKMG ------------------------------------------------------------ ------NPQRAL-----LYLVAALKEGSTWGLPLLE------------------------ ---------------------------------------------------------ASR LYRQLGNT----------AAELESLELLVEALNVT----HS---SEA------------- --------PQLL----------------------------------IEVEL--------- ------------------------------------------------------------ -------LLPQPNPGSPLHCGT-------------------------------------- -------------------------------QSQAKYLL--------------------- --------------ASRCLQV--------------------------------------- ------------------------------------------------------------ -----GRAED----------AAEHY----------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ LDL--------------------------------------------------------- ------------------------------------------------------------ -----LALLL-SDS---------------------------------------------- -------------------------------------------------------EPK-- ------------------------------------------------------------ ---------------------------------------------F------S------- -----PPPTHP-GPCMPEVFLEAAAALIQAGRAQDA------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ LTVCE------------------------------------------------------- ---------------------------------------------------------ELL SRTSSL-----LPKMPQLW---------------------------EDDKK--------- ------------------------------------------------------------ ---------------------------------------------------------GT- ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------K------------------- ------------------------------------------------------------ -----------KSPH--------------CPSWVSA------------------------ ------------------------------------------------------------ ------------------------------------------------------TYLLQG QAWVQL--GAQKEAISEFSRCLELLFRT-------------------------------- --------TPK-DK---------------EQ----------------------------- -----------------GP--------AS----------NGEQGCM-------------- ----------------------SDV------------------A---------------- -----------------------LPQL--------------------------------- --------------------------------------------RAAALISRGLQWVAS- ---------------------------------------------------------GQD TRALQDFLLGV------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------QMCP------------------------ ----------------------------------------GNQDASFH------------ ---------------------------------------LLQTLRKM------------- ----------------------------------------------------DRRDEASA L---------------------W------------------------WRLEAQT-----K L-P----QENAA----------W-------------S----------------------- ------------------LPLYLETC---------------------------------- -----------------------------------------------------LGWICYP DRETLLEE----------------------------------------FRTSL------- ------------------------------------------------------------ -------PEPCD-L------------------------ >ENSPTIP00000012020 M----------------------------------------------------------- ------------------------------------------------------------ -----------------------------------------------QKRTDLSSLGWGP RRGRAYLSAAPSRGLGPA------------------------------------------ -----------------SATL-----------SHQT------------------------ ----------------------PL-GSSGL--------------------HAS------- ------CLDLWREKNDQLVRQAK-VA-QD------------------------------- ------------------------------------------SRQF-------------- ------------------------LRGQ-------------------------------- --------QLAQD---------------------------------------------VL EGFRGLLHSL-------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------Q----------------------------------G--- -------------------------------------------LPAAVPVLP-------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------LELTVTCNFITMKAS- -LAQGFTENQAQDIQQSLER----------------------------------VLETQK -QLG---PRLECGLRGL---------------WDSV------------------------ ------------------------------------------------------------ ---------LHYSSVLLELLPALHHLAG-------------------------------- ------------------------------------------------------------ ---------------------------LQA------------------------------ ---------------------------ALWLSTDCLGDLTLL------------------ ---------------------------------------------------------LQT LNG----------------------NQ--------S---EAS------------------ --EDLLH-----LLKTWSPPAEE------------------------------------- -----------------------------------------------------SDAPLTL QDARGLRDVLL-------------------------------------------T----- ---------------ASAYRQGL--------QELITGSL----------------PKALS SLQEAASGLCPRPV------------------------------LVQVYTVLGTCLRKMG ------------------------------------------------------------ ------NPQRAL-----LYLVAALKGGSPWGPPLLE------------------------ ---------------------------------------------------------ASR LYQQLGNT----------AAELESLELLVDALSVT----HS---PEA------------- --------PQLL----------------------------------IEVEL--------- ------------------------------------------------------------ -------LLPQPNPASPLHCGT-------------------------------------- -------------------------------QSQAKYLL--------------------- --------------ASRCLQI--------------------------------------- ------------------------------------------------------------ -----GRAED----------AAEHY----------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ LDL--------------------------------------------------------- ------------------------------------------------------------ -----LALLL-DDS---------------------------------------------- -------------------------------------------------------EPK-- ------------------------------------------------------------ ---------------------------------------------F------S------- -----PPPSRP-GPCMPEVFLEAAAALIQAGRAQDA------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ LTVCE------------------------------------------------------- ---------------------------------------------------------ELL SRMSSL-----LPKMPQLW---------------------------EDARK--------- ------------------------------------------------------------ ---------------------------------------------------------GT- ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------K------------------- ------------------------------------------------------------ -----------ESPH--------------CLSWVSA------------------------ ------------------------------------------------------------ ------------------------------------------------------TYLLQG RAWVQL--GAQKEAISEFSRCLELLFQA-------------------------------- --------TPK-DK---------------EQ----------------------------- -----------------GP--------AS----------SCEQGCM-------------- ----------------------SDV------------------A---------------- -----------------------LQQL--------------------------------- --------------------------------------------RVAALISRGLQWVAS- ---------------------------------------------------------DQD TKALQDFLLSV------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------QMCP------------------------ ----------------------------------------GNRDASFH------------ ---------------------------------------LLQTLRRM------------- ----------------------------------------------------DRRDEAIA L---------------------W------------------------WSLEAQA-----K L-P----QENAA----------W-------------S----------------------- ------------------LPLFLETY---------------------------------- -----------------------------------------------------LSWIRSP DRETLLEE----------------------------------------FQTSL------- ------------------------------------------------------------ -------LEPCD-L------------------------ >ENSPPRP00000009227 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------L-----------SHQT------------------------ ----------------------PL-GSSGL--------------------HAS------- ------CLDLWREKNDQLVRQAK-VA-QD------------------------------- ------------------------------------------SRQF-------------- ------------------------LRGQ-------------------------------- --------QLAQD---------------------------------------------VL EGFRGLLHSL-------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------Q----------------------------------G--- -------------------------------------------LPAAVPVLP-------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------LELTVTCNFITMKAS- -LAQGFTENQAQDIQQSLER----------------------------------VLETQK -QLG---PRLECGLRGL---------------WDSV------------------------ ------------------------------------------------------------ ---------LHYSSVLLELLPALHHLAG-------------------------------- ------------------------------------------------------------ ---------------------------LQA------------------------------ ---------------------------ALWLSTDCLGDLTLL------------------ ---------------------------------------------------------LQT LNG----------------------NQ--------S---EAS------------------ --EDLLH-----LLKTWSPPAEE------------------------------------- -----------------------------------------------------SDAPLTL QDARGLRDVLL-------------------------------------------T----- ---------------ASAYRQGL--------QELITGSL----------------PKALS SLQEAASGLCPRPV------------------------------LVQVYTVLGTCLRKMG ------------------------------------------------------------ ------NPQRAL-----LYLVAALKGGSPWGPPLLE------------------------ ---------------------------------------------------------ASR LYQQLGNT----------AAELESLELLVDALSVT----HS---PEA------------- --------PQLL----------------------------------IEVEL--------- ------------------------------------------------------------ -------LLPQPNPASPLHCGT-------------------------------------- -------------------------------QSQAKYLL--------------------- --------------ASRCLQI--------------------------------------- ------------------------------------------------------------ -----GRAED----------AAEHY----------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ LDL--------------------------------------------------------- ------------------------------------------------------------ -----LALLL-DDS---------------------------------------------- -------------------------------------------------------EPK-- ------------------------------------------------------------ ---------------------------------------------F------S------- -----PPPSRP-GPCMPEVFLEAAAALIQAGRAQDA------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ LTVCE------------------------------------------------------- ---------------------------------------------------------ELL SRMSSL-----LPKMPQLW---------------------------EDARK--------- ------------------------------------------------------------ ---------------------------------------------------------GT- ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------K------------------- ------------------------------------------------------------ -----------ESPH--------------CLSWVSA------------------------ ------------------------------------------------------------ ------------------------------------------------------TYLLQG RAWVQL--GAQKEAISEFSRCLELLFQA-------------------------------- --------TPK-DK---------------EQ----------------------------- -----------------GP--------AS----------SCEQGCM-------------- ----------------------SDV------------------A---------------- -----------------------LQQL--------------------------------- --------------------------------------------RVAALISRGLQWVAS- ---------------------------------------------------------DQD TKALQDFLLSV------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------QMCP------------------------ ----------------------------------------GNRDASFH------------ ---------------------------------------LLQTLRRM------------- ----------------------------------------------------DRRDEAIA L---------------------W------------------------WSLEAQA-----K L-P----QENAA----------W-------------S----------------------- ------------------LPLFLETY---------------------------------- -----------------------------------------------------LSWIRSP DRETLLEE----------------------------------------FQTSL------- ------------------------------------------------------------ -------LEPCD-L------------------------ >ENSFCAP00000045883 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------L-----------SHQT------------------------ ----------------------PL-GSSGL--------------------HAS------- ------CLDLWREKNDQLVRQAK-VA-QD------------------------------- ------------------------------------------SRQF-------------- ------------------------LRGQ-------------------------------- --------QLAQD---------------------------------------------VL EGFRGLLHSL-------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------Q----------------------------------G--- -------------------------------------------LPAAVPVLP-------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------LELTVTCNFITMKAS- -LAQGFTEDQAQDIQQSLER----------------------------------VLETQE -QLG---PRLECGLRGL---------------WDSV------------------------ ------------------------------------------------------------ ---------LHYSSVLLELLPALHHLAG-------------------------------- ------------------------------------------------------------ ---------------------------LQA------------------------------ ---------------------------ALWLSTDCLGDLTLL------------------ ---------------------------------------------------------LQT LNG----------------------NQ--------S---EAS------------------ --EDLLH-----LLKTWSPPAEE------------------------------------- -----------------------------------------------------SDAPLTL QDARGLRDVLL-------------------------------------------T----- ---------------ASAYRQGL--------QELITGSL----------------PKALS SLQEAASGLCPRPV------------------------------LVQVYTVLGTCLRKMG ------------------------------------------------------------ ------NPQRAL-----LYLVAALKGGSPWGPPLLE------------------------ ---------------------------------------------------------ASR LYQQLGNT----------AAELESLELLVDALSVT----HS---PEA------------- --------PQLL----------------------------------IEVEL--------- ------------------------------------------------------------ -------LLPQPNPASPLHCGT-------------------------------------- -------------------------------QSQAKYLL--------------------- --------------ASRCLQI--------------------------------------- ------------------------------------------------------------ -----GRAED----------AAEHY----------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ LDL--------------------------------------------------------- ------------------------------------------------------------ -----LALLL-DDS---------------------------------------------- -------------------------------------------------------EPK-- ------------------------------------------------------------ ---------------------------------------------F------S------- -----PPPSRP-GPCMPEVFLEAAAALIQAGRAQDA------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ LTVCE------------------------------------------------------- ---------------------------------------------------------ELL SRMSSL-----LPKMPQLW---------------------------EDARK--------- ------------------------------------------------------------ ---------------------------------------------------------GT- ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------K------------------- ------------------------------------------------------------ -----------ESPH--------------CLSWVSA------------------------ ------------------------------------------------------------ ------------------------------------------------------TYLLQG RAWVQL--GAQKEAISEFSRCLELLFQA-------------------------------- --------TPK-DK---------------EQ----------------------------- -----------------GP--------AS----------SYEQGCM-------------- ----------------------SDV------------------A---------------- -----------------------LQQL--------------------------------- --------------------------------------------RVAALISRGLQWVAS- ---------------------------------------------------------DQD TKALQDFLLSV------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------QMCP------------------------ ----------------------------------------GNRDASFH------------ ---------------------------------------LLQTLRRM------------- ----------------------------------------------------DRRDEAIA L---------------------W------------------------RSLEAQA-----K L-P----QENAA----------W-------------S----------------------- ------------------LPLYLETY---------------------------------- -----------------------------------------------------LSWIRSP DRETLLEE----------------------------------------FQTSL------- ------------------------------------------------------------ -------LEPCD-L------------------------ >ENSEASP00005020000 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------MGEPSVRSTFIA---------------------LG--- -------------------------------------------LPAAVPVLP-------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------LELTVICNFITLRAS- -LAQGFTEDQAQGIQQGLER----------------------------------VLETQE -QLE---PRLECGLSAL---------------WDSV------------------------ ------------------------------------------------------------ ---------LHSSSLLPELLPALHHLAA-------------------------------- ------------------------------------------------------------ ---------------------------LQA------------------------------ ---------------------------ALWLTTDHLGDLTLL------------------ ---------------------------------------------------------LQT LNG----------------------SQ--------S---GAS------------------ --EDLLL-----LLKTWNLPAEE------------------------------------- -----------------------------------------------------SDAPLTI QDARGLRDVLL-------------------------------------------T----- ---------------ASAYRQGL--------QELITGRL----------------SRALS SLHEAASGLCPQPV------------------------------LVQVYTALGTCLSKMG ------------------------------------------------------------ ------NPQRAL-----LYLLSALKGGSTWGPALLE------------------------ ---------------------------------------------------------ASR LYRQLGNT----------AAELESLELLVEALSIT----HG---SEA------------- --------PQLL----------------------------------IEVEL--------- ------------------------------------------------------------ -------LLPRPEPASPLYCGT-------------------------------------- -------------------------------QSQAKYLL--------------------- --------------ASRCLQT--------------------------------------- ------------------------------------------------------------ -----GRAED----------AAEHY----------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ LDL--------------------------------------------------------- ------------------------------------------------------------ -----LALLL-DGS---------------------------------------------- -------------------------------------------------------EPK-- ------------------------------------------------------------ ---------------------------------------------I------S------- -----PPPCPT-GPCMPEVFLEAAAALIRAGRAQDA------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ LTVCE------------------------------------------------------- ---------------------------------------------------------ELL SRMSSL-----LPKMPQPW---------------------------GNARK--------- ------------------------------------------------------------ ---------------------------------------------------------GT- ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------K------------------- ------------------------------------------------------------ -----------ESPH--------------CPPWVSA------------------------ ------------------------------------------------------------ ------------------------------------------------------THLLRG QAWVQL--GAQKEAISEFSRCLELLFRA-------------------------------- --------TPT-DK---------------EQ----------------------------- -----------------GP--------AS----------NCEQGCT-------------- ----------------------SDV------------------A---------------- -----------------------LQQL--------------------------------- --------------------------------------------RAAALISRGLGWVTS- ---------------------------------------------------------GQD TKALQDFLLSV------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------QMCP------------------------ ----------------------------------------GNQDASFH------------ ---------------------------------------LLQTLRRL------------- ----------------------------------------------------DRRDEAIA F---------------------W------------------------RRLEAQT-----K L-P----QENAT----------W-------------S----------------------- ------------------LPLYLETC---------------------------------- -----------------------------------------------------LSWIRPH DRETLLEE----------------------------------------FQTSL------- ------------------------------------------------------------ -------LEPCD-L------------------------ >ENSECAP00000013855 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------R-----------SHET------------------------ ----------------------PL-GSSTP--------------------HAS------- ------CLDLWRQRNDQLVRQAK-VA-QG------------------------------- --------------------------------------------LS-------------- ------------------------LRRQ-------------------------------- --------QLAQD---------------------------------------------AL EGFRELLHCL-------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------Q----------------------------------G--- -------------------------------------------LPAAVPVLP-------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------LELTVICNFITLRAS- -LAQGFTEDQAQGIQQGLER----------------------------------VLETQE -QLE---PRLECGLSAL---------------WDSV------------------------ ------------------------------------------------------------ ---------LHSSSLLPELLPALHHLAA-------------------------------- ------------------------------------------------------------ ---------------------------LQA------------------------------ ---------------------------ALWLTTDHLGDLTLL------------------ ---------------------------------------------------------LQT LNG----------------------SQ--------S---GAS------------------ --EDLLL-----LLKTWNLPAEE------------------------------------- -----------------------------------------------------SDAPLTI QDARGLRDVLL-------------------------------------------T----- ---------------ASAYRQGL--------QELITGRL----------------SRALS SLHEAASGLCPQPV------------------------------LVQVYTALGTCLSKMG ------------------------------------------------------------ ------NPQRAL-----LYLLSALKGGSTWGPALLE------------------------ ---------------------------------------------------------ASR LYRQLGNT----------AAELESLELLVETLSIT----HG---SEA------------- --------PQLL----------------------------------IEVEL--------- ------------------------------------------------------------ -------LLPRPEPASPLYCGT-------------------------------------- -------------------------------QSQAKYLL--------------------- --------------ASRCLQT--------------------------------------- ------------------------------------------------------------ -----GRAED----------AAEHY----------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ LDL--------------------------------------------------------- ------------------------------------------------------------ -----LALLL-DGS---------------------------------------------- -------------------------------------------------------EPK-- ------------------------------------------------------------ ---------------------------------------------I------S------- -----PPPCPT-GPCMPEVFLEAAAALIRAGRAQDA------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ LTVCE------------------------------------------------------- ---------------------------------------------------------ELL SRMSSL-----LPKMPQPW---------------------------GNARK--------- ------------------------------------------------------------ ---------------------------------------------------------GT- ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------K------------------- ------------------------------------------------------------ -----------ESPH--------------CPPWVSA------------------------ ------------------------------------------------------------ ------------------------------------------------------THLLRG QAWVQL--GAQKEAISEFSRCLELLFRA-------------------------------- --------TPT-DK---------------EQ----------------------------- -----------------GP--------AS----------NCEQGCT-------------- ----------------------SDV------------------A---------------- -----------------------LQQL--------------------------------- --------------------------------------------RAAALISRGLGWVTS- ---------------------------------------------------------GQD TKALQDFLLSV------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------QMCP------------------------ ----------------------------------------GNQDASFH------------ ---------------------------------------LLQTLRRL------------- ----------------------------------------------------DRRDEAIA L---------------------W------------------------RRLEAQT-----K L-P----QENAT----------W-------------S----------------------- ------------------LPLYLETC---------------------------------- -----------------------------------------------------LSWICPH DRETLLEE----------------------------------------FQTSL------- ------------------------------------------------------------ -------LEPCD-L------------------------ >ENSBIXP00000015257 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------M-----------AHQT------------------------ ----------------------PL-GSSAS--------------------HVS------- ------CLDLWREKNDQLVRQAK-VA-QD------------------------------- ------------------------------------------SSLP-------------- ------------------------MRRQ-------------------------------- --------QLAQD---------------------------------------------AL EGLRGLLCSL-------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------R----------------------------------G--- -------------------------------------------LPATVSVLP-------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------LELTVICNFITLRAN- -LAQGFTEDLAQDIQQGLER----------------------------------VLETQG -QLE---ARLEHGLWGL---------------WDST------------------------ ------------------------------------------------------------ ---------LRVSSLLPELLPALHHLAG-------------------------------- ------------------------------------------------------------ ---------------------------LQA------------------------------ ---------------------------ALWLTTNRLGDLTLL------------------ ---------------------------------------------------------LQT LTV----------------------SQ--------S---RAS------------------ --EDMLL-----LLKTWRPPAEE------------------------------------- -----------------------------------------------------SDAPLTL QDARGLRDVLL-------------------------------------------T----- ---------------AFAYRQGL--------QELITGSL----------------PKALS SLHEAASGLCPRSL------------------------------LVQVYTALGTCLRKMG ------------------------------------------------------------ ------SPQRAL-----LYLVAALKEGSTWGPPLLE------------------------ ---------------------------------------------------------ASR LYQQLGNI----------AAEIESLELLVEALSIT----RI---PEA------------- --------RQLL----------------------------------IEVEL--------- ------------------------------------------------------------ -------LLPQPDPASPLHCGT-------------------------------------- -------------------------------QSQAKYLL--------------------- --------------ASRCLQT--------------------------------------- ------------------------------------------------------------ -----GRAAD----------AAEHY----------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ LDL--------------------------------------------------------- ------------------------------------------------------------ -----LALLL-DGS---------------------------------------------- -------------------------------------------------------EPK-- ------------------------------------------------------------ ---------------------------------------------F------S------- -----PPPCPP-GPCVPELFLEAAAALIQAGRAQDA------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ LTVCE------------------------------------------------------- ---------------------------------------------------------ELL SRTSFL-----LPKRPRLW---------------------------EDARR--------- ------------------------------------------------------------ ---------------------------------------------------------RT- ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------K------------------- ------------------------------------------------------------ -----------ESPH--------------CSHWVSA------------------------ ------------------------------------------------------------ ------------------------------------------------------THLLQG QAWVQL--GAQKEAISEYSRCLELLFRA-------------------------------- --------TPK-DK---------------EQ----------------------------- -----------------GP--------AS----------SCEQGCT-------------- ----------------------SDM------------------A---------------- -----------------------LQQL--------------------------------- --------------------------------------------QTAALISRGLEWVAL- ---------------------------------------------------------GQD TKALQDFLLSV------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------QMCP------------------------ ----------------------------------------GNQDASYH------------ ---------------------------------------LLQTLRRL------------- ----------------------------------------------------DRRDEATA L---------------------W------------------------RRLEAQT-----E L-P----QENTA----------W-------------S----------------------- ------------------LPLYLETC---------------------------------- -----------------------------------------------------LGWIRPP DRETLCEE----------------------------------------FQTS-------- ------------------------------------------------------------ --------G--D-S------------------------ >ENSBIXP00005030608 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------M-----------AHQT------------------------ ----------------------PL-GSSAS--------------------HVS------- ------CLDLWREKNDQLVRQAK-VA-QD------------------------------- ------------------------------------------SSLP-------------- ------------------------MRRQ-------------------------------- --------QLAQD---------------------------------------------AL EGLRGLLCSL-------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------R----------------------------------G--- -------------------------------------------LPATVSVLP-------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------LELTVICNFITLRAN- -LAQGFTEDLAQDIQQGLER----------------------------------VLETQG -QLE---ARLEHGLWGL---------------WDST------------------------ ------------------------------------------------------------ ---------LRVSSLLPELLPALHHLAG-------------------------------- ------------------------------------------------------------ ---------------------------LQA------------------------------ ---------------------------ALWLTTNRLGDLTLL------------------ ---------------------------------------------------------LQT LTV----------------------SQ--------S---RAS------------------ --EDMLL-----LLKTWRPPAEE------------------------------------- -----------------------------------------------------SDAPLTL QDARGLRDVLL-------------------------------------------T----- ---------------AFAYRQGL--------QELITGSL----------------PKALS SLHEAASGLCPRSL------------------------------LVQVYTALGTCLRKMG ------------------------------------------------------------ ------SPQRAL-----LYLVAALKEGSTWGPPLLE------------------------ ---------------------------------------------------------ASR LYQQLGNI----------AAEIESLELLVEALSIT----RI---PEA------------- --------RQLL----------------------------------IEVEL--------- ------------------------------------------------------------ -------LLPQPDPASPLHCGT-------------------------------------- -------------------------------QSQAKYLL--------------------- --------------ASRCLQT--------------------------------------- ------------------------------------------------------------ -----GRAAD----------AAEHY----------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ LDL--------------------------------------------------------- ------------------------------------------------------------ -----LALLL-DGS---------------------------------------------- -------------------------------------------------------EPK-- ------------------------------------------------------------ ---------------------------------------------F------S------- -----PPPCPP-GPCVPELFLEAAAALIQAGRAQDA------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ LTVCE------------------------------------------------------- ---------------------------------------------------------ELL SRTSFL-----LPKRPRLW---------------------------EDARR--------- ------------------------------------------------------------ ---------------------------------------------------------RT- ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------K------------------- ------------------------------------------------------------ -----------ESPH--------------CSHWVSA------------------------ ------------------------------------------------------------ ------------------------------------------------------THLLQG QAWVQL--GAQKEAISEYSRCLELLFRA-------------------------------- --------TPK-DK---------------EQ----------------------------- -----------------GP--------AS----------SCEQGCT-------------- ----------------------SDM------------------A---------------- -----------------------LQQL--------------------------------- --------------------------------------------QTAALISRGLEWVAL- ---------------------------------------------------------GQD TKALQDFLLSV------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------QMCP------------------------ ----------------------------------------GNQDASYH------------ ---------------------------------------LLQTLRRL------------- ----------------------------------------------------DRRDEATA L---------------------W------------------------RRLEAQT-----E L-P----QENTA----------W-------------S----------------------- ------------------LPLYLETC---------------------------------- -----------------------------------------------------LGWIRPP DRETLCEE----------------------------------------FQTS-------- ------------------------------------------------------------ --------G--D-S------------------------ >ENSBBBP00000007203 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------M-----------AHQT------------------------ ----------------------PL-GSSAS--------------------HVS------- ------CLDLWREKNDQLVRQAK-VA-QD------------------------------- ------------------------------------------SSLP-------------- ------------------------MRRQ-------------------------------- --------QLAQD---------------------------------------------AL EGLRGLLCSL-------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------R----------------------------------G--- -------------------------------------------LPATVSVLP-------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------LELTVICNFITLRAN- -LAQGFTEDLAQDIQQGLER----------------------------------VLETQG -QLE---ARLEHGLWGL---------------WDST------------------------ ------------------------------------------------------------ ---------LRVSSLLPELLPALHHLAG-------------------------------- ------------------------------------------------------------ ---------------------------LQA------------------------------ ---------------------------ALWLTTNCLGDLTLL------------------ ---------------------------------------------------------LQT LTV----------------------SQ--------S---RAS------------------ --EDMLL-----LLKTWRPPAEE------------------------------------- -----------------------------------------------------SDAPLTL QDARGLRDVLL-------------------------------------------T----- ---------------AFAYRQGL--------QELITGSL----------------PKALS SLHEAASGLCPRSL------------------------------LVQVYTALGTCLRKMG ------------------------------------------------------------ ------SPQRAL-----LYLVAALKEGSTWGPPLLE------------------------ ---------------------------------------------------------ASR LYQQLGNI----------AAEIESLELLVEALSIT----RI---PEA------------- --------RQLL----------------------------------IEVEL--------- ------------------------------------------------------------ -------LLPQPDPASPLHCGT-------------------------------------- -------------------------------QSQAKYLL--------------------- --------------ASRCLQT--------------------------------------- ------------------------------------------------------------ -----GRAAD----------AAEHY----------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ LDL--------------------------------------------------------- ------------------------------------------------------------ -----LALLL-DGS---------------------------------------------- -------------------------------------------------------EPK-- ------------------------------------------------------------ ---------------------------------------------F------S------- -----PPPCPP-GPCVPELFLEAAAALIQAGRAQDA------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ LTVCE------------------------------------------------------- ---------------------------------------------------------ELL SRTSFL-----LPKRPRLW---------------------------EDARR--------- ------------------------------------------------------------ ---------------------------------------------------------RT- ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------K------------------- ------------------------------------------------------------ -----------ESPH--------------CSHWVSA------------------------ ------------------------------------------------------------ ------------------------------------------------------THLLQG QAWVQL--GAQKEAISEYSRCLELLFRA-------------------------------- --------TPK-DK---------------EQ----------------------------- -----------------GP--------AS----------SCEQGCT-------------- ----------------------SDM------------------A---------------- -----------------------LQQL--------------------------------- --------------------------------------------QTAALISRGLEWVAL- ---------------------------------------------------------GQD TKALQDFLLSV------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------QMCP------------------------ ----------------------------------------GNQDASYH------------ ---------------------------------------LLQTLRRL------------- ----------------------------------------------------DRRDEATA L---------------------W------------------------RRLEAQT-----E L-P----QENTA----------W-------------S----------------------- ------------------FPLYLETC---------------------------------- -----------------------------------------------------LGWIRPP DRETLCEE----------------------------------------FQTS-------- ------------------------------------------------------------ --------ETCD-L------------------------ >ENSBMUP00000031274 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------M-----------AHQT------------------------ ----------------------PL-GSSAS--------------------HVS------- ------CLDLWREKNDQLVRQAK-VA-QD------------------------------- ------------------------------------------SSLP-------------- ------------------------MRRQ-------------------------------- --------QLAQD---------------------------------------------AL EGLRGLLCSL-------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------R----------------------------------G--- -------------------------------------------LPATVSVLP-------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------LELTVLCNFITLRAN- -LAQGFTEDLAQDIQQGLER----------------------------------VLETQG -QLE---ARLEHGLWGL---------------WDST------------------------ ------------------------------------------------------------ ---------LRVSSLLPELLPALHHLAG-------------------------------- ------------------------------------------------------------ ---------------------------LQA------------------------------ ---------------------------ALWLTTNRLGDLTLL------------------ ---------------------------------------------------------LQT LTV----------------------SQ--------S---RAS------------------ --EDMLL-----LLKTWRPPAEE------------------------------------- -----------------------------------------------------SGAPLTL QDARGLRDVLL-------------------------------------------T----- ---------------AFAYRQGL--------QELITGSL----------------PKALS SLHEAASGLCPRSL------------------------------LVQVYTALGTCLRKMG ------------------------------------------------------------ ------SPQRAL-----LYLVAALKEGSTWGPPLLE------------------------ ---------------------------------------------------------ASR LYQQLGNI----------AAEIESLELLVEALSIT----CI---PEA------------- --------RQLL----------------------------------IEVEL--------- ------------------------------------------------------------ -------LLPQPDPASPLHCGT-------------------------------------- -------------------------------QSQAKYLL--------------------- --------------ASRCLQT--------------------------------------- ------------------------------------------------------------ -----GRAAD----------AAEHY----------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ LDL--------------------------------------------------------- ------------------------------------------------------------ -----LALLL-DSS---------------------------------------------- -------------------------------------------------------EPK-- ------------------------------------------------------------ ---------------------------------------------F------S------- -----PPPCPP-GPCVPELFLEAAAALIQAGRAQDA------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ LTVCE------------------------------------------------------- ---------------------------------------------------------ELL SRTSFL-----LPKRPRLW---------------------------EDARR--------- ------------------------------------------------------------ ---------------------------------------------------------RT- ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------K------------------- ------------------------------------------------------------ -----------ESPH--------------CSHWVSA------------------------ ------------------------------------------------------------ ------------------------------------------------------THLLQG QAWVQL--GAQKEAISEYSRCLELLFRA-------------------------------- --------TPK-DK---------------EQ----------------------------- -----------------GP--------AS----------SCEQGCT-------------- ----------------------SDM------------------A---------------- -----------------------LQQL--------------------------------- --------------------------------------------QTAALISRGLEWVAL- ---------------------------------------------------------GQD TKALQDFLLSV------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------QMCP------------------------ ----------------------------------------GNQDASYH------------ ---------------------------------------LLQTLRRL------------- ----------------------------------------------------DRRDEATA L---------------------W------------------------QRLEAQT-----E L-P----QENTA----------W-------------S----------------------- ------------------LPLYLETC---------------------------------- -----------------------------------------------------LGWIRPP DRETLCEE----------------------------------------FQTS-------- ------------------------------------------------------------ --------ETCD-L------------------------ >ENSSSCP00000052519 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------M-----------AHKT------------------------ ----------------------LL-GSSTS--------------------HDS------- ------CLDLWREKNDQLVRQAK-VA-QN------------------------------- ------------------------------------------LSLS-------------- ------------------------LRRQ-------------------------------- --------QLVQD---------------------------------------------VL EGLRGLLHSL-------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------Q----------------------------------G--- -------------------------------------------LPATVSVLP-------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------LELTVICNFITLRAS- -LAQGFTEDLAPDIQRGLER----------------------------------VLETQE -QQE---ARLEHRLRGL---------------WDSV------------------------ ------------------------------------------------------------ ---------LHVSSLLPELLPALHHLAG-------------------------------- ------------------------------------------------------------ ---------------------------LQA------------------------------ ---------------------------ALWLSTDRLEDLTLL------------------ ---------------------------------------------------------LQT LNG----------------------SE--------S---SAS------------------ --EELLL-----LLKTWRPPVET------------------------------------- -----------------------------------------------------SDAPLTL QDARSLRDVLL-------------------------------------------T----- ---------------AFAYRQGL--------RELITGSL----------------PRALS SLHEAASGLCPRPV------------------------------LVQVYTALATCLRKMG ------------------------------------------------------------ ------KPQRAL-----LYLVEAVKGESIWGPPLLE------------------------ ---------------------------------------------------------ASR LYQQLGNT----------AAEIESLELLVEALSVT----HI---PEA------------- --------PQLL----------------------------------IEVEL--------- ------------------------------------------------------------ -------LLPPPDPASPLHCGT-------------------------------------- -------------------------------QSQAKYLL--------------------- --------------ASRCLQT--------------------------------------- ------------------------------------------------------------ -----RRVED----------AAEHY----------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ LDL--------------------------------------------------------- ------------------------------------------------------------ -----LALLL-DGS---------------------------------------------- -------------------------------------------------------EPK-- ------------------------------------------------------------ ---------------------------------------------F------S------- -----PPPCPP-GPCVPEVFLEAAVALIQAGRAQDA------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ LTVCE------------------------------------------------------- ---------------------------------------------------------ELL SRTSSL-----LPKRPRLW---------------------------EDARK--------- ------------------------------------------------------------ ---------------------------------------------------------GT- ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------K------------------- ------------------------------------------------------------ -----------ESPH--------------CSPWISA------------------------ ------------------------------------------------------------ ------------------------------------------------------IYLLQG QAWVQL--GAQKEAVSEFSRCLELLFQV-------------------------------- --------TPK-DK---------------EP----------------------------- -----------------GP--------AS----------SCEHGCT-------------- ----------------------SDV------------------V---------------- -----------------------LQQL--------------------------------- --------------------------------------------RAAALISRGLEWVAG- ---------------------------------------------------------GQD NKALQDFLLSV------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------QVCP------------------------ ----------------------------------------GNQDASFH------------ ---------------------------------------LLQTLRRL------------- ----------------------------------------------------DRRDEAIA F---------------------W------------------------QRLEAQT-----D L-P----QENAT----------W-------------S----------------------- ------------------LPLYLETY---------------------------------- -----------------------------------------------------LDWIRPP DREALLEE----------------------------------------FRTSL------- ------------------------------------------------------------ --------LTCD-LK----------------------- >ENSSBOP00000011801 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------M-----------FCQT------------------------ ----------------------TPLGS-------------------------S------- ------CLDMWREKNDRLVRQAK-VA-QN------------------------------- ------------------------------------------SSLT-------------- ------------------------LRRQ-------------------------------- --------QLAQD---------------------------------------------AL EGLGGLLHSL-------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------Q----------------------------------G--- -------------------------------------------LPAAVPVLH-------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------LELTVTCNFIILRAS- -LAQGFTEDQAQVIQRGLER----------------------------------VLETQE -QLG---PRLEQGLKEL---------------WDSV------------------------ ------------------------------------------------------------ ---------LHTSSLLPELLPALHRLAG-------------------------------- ------------------------------------------------------------ ---------------------------LQA------------------------------ ---------------------------ALWLSTDRLGDLALL------------------ ---------------------------------------------------------LET LNG----------------------SQ--------S---GAS------------------ --EDLLL-----LLKTWSLPAEE------------------------------------- -----------------------------------------------------LDAPLTL QDAQGLKDVLL-------------------------------------------T----- ---------------AFAYRQGL--------QELITGNL----------------DRALS SLHEVASGLCPRPL------------------------------LVQVYTALGSCHRKMG ------------------------------------------------------------ ------NPQRAL-----LYLVAALKEGSAWGPPLLE------------------------ ---------------------------------------------------------ASR LYQQLGDT----------TAELESLELLVEALNVP----CN---SKA------------- --------PQFL----------------------------------IEVEL--------- ------------------------------------------------------------ -------LLPPPDPASPLHCGT-------------------------------------- -------------------------------QSQAKHVL--------------------- --------------ASRCLQT--------------------------------------- ------------------------------------------------------------ -----GRVED----------AAEHY----------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ LDL--------------------------------------------------------- ------------------------------------------------------------ -----LALLL-DSS---------------------------------------------- -------------------------------------------------------EPR-- ------------------------------------------------------------ ---------------------------------------------F------S------- -----LPRSHP-GPCMPELFLEAAVALIQAGRAQDA------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ LTLCE------------------------------------------------------- ---------------------------------------------------------ELL SHTSSL-----LPKMFRLW---------------------------EDARK--------- ------------------------------------------------------------ ---------------------------------------------------------GT- ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------K------------------- ------------------------------------------------------------ -----------ELPY--------------CPLWVSA------------------------ ------------------------------------------------------------ ------------------------------------------------------THLLQG QAWVQL--GAQKMAVSEFSRCLELLFRA-------------------------------- --------IPE-DK---------------VQ----------------------------- -----------------GA--------AS----------NCEQECK-------------- ----------------------SDM------------------A---------------- -----------------------LQQL--------------------------------- --------------------------------------------RAAALISRGLEWVAS- ---------------------------------------------------------GQD TKALQDFLLAV------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------QMCP------------------------ ----------------------------------------GNRDTYFH------------ ---------------------------------------LLQTLRRL------------- ----------------------------------------------------DRRDEATA L---------------------W------------------------RRLEAQT-----K G-P----QEGAI----------W-------------S----------------------- ------------------LPLYLESY---------------------------------- -----------------------------------------------------LSWIRPS DREALLEE----------------------------------------FQTSL------- ------------------------------------------------------------ -------LESCD-L------------------------ >ENSANAP00000019215 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------M-----------SCQT------------------------ ----------------------TPLDS-------------------------S------- ------CLDLWREKNDRLVRQVK-VA-QN------------------------------- ------------------------------------------SGLT-------------- ------------------------LRRQ-------------------------------- --------RLAQD---------------------------------------------AL EGLRGLLHSL-------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------Q----------------------------------G--- -------------------------------------------LPAAVPVLP-------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------LELTVTCNFIILRAS- -LAQGFTEDQVQDIQRGLER----------------------------------VLETQE -QLG---PRLEQGLKEL---------------WHSV------------------------ ------------------------------------------------------------ ---------LHASSLLPELLSALHCLAG-------------------------------- ------------------------------------------------------------ ---------------------------LQA------------------------------ ---------------------------ALWLSTDRLGDLGLL------------------ ---------------------------------------------------------LET LNG----------------------SQ--------S---GAS------------------ --EDLLL-----LLKTWSPPAEE------------------------------------- -----------------------------------------------------LDVPLTL QDAQGLKDVLL-------------------------------------------T----- ---------------AFAYRQGL--------QELITGNL----------------DRALS SLHEVASGLCPRPV------------------------------LVQVYTALGSCHRKMG ------------------------------------------------------------ ------NPQRAL-----LYLVAALKEGSAWGPPLLE------------------------ ---------------------------------------------------------ASR LYQQLGDT----------TAELESLELLVEALNVP----CS---SKA------------- --------PQFL----------------------------------IEVEL--------- ------------------------------------------------------------ -------LLPPPDPASPLHCGT-------------------------------------- -------------------------------QSQAKHVL--------------------- --------------ASRCLQT--------------------------------------- ------------------------------------------------------------ -----GRAED----------AAEHY----------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ LDL--------------------------------------------------------- ------------------------------------------------------------ -----LALLL-DSS---------------------------------------------- -------------------------------------------------------EPR-- ------------------------------------------------------------ ---------------------------------------------F------F------- -----LPRSRP-GPCMPELFLEAAVALIQAGRAQDA------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ LTLCE------------------------------------------------------- ---------------------------------------------------------ELL SRTSSL-----LPKMSRLW---------------------------EDARK--------- ------------------------------------------------------------ ---------------------------------------------------------GT- ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------K------------------- ------------------------------------------------------------ -----------ELPY--------------CPLWVSA------------------------ ------------------------------------------------------------ ------------------------------------------------------THLLQG QAWVQL--GAQKMAVSEFSRCLELLFRA-------------------------------- --------IPE-DK---------------GQ----------------------------- -----------------GA--------AS----------NCEQGCK-------------- ----------------------SDV------------------A---------------- -----------------------LQQL--------------------------------- --------------------------------------------RAAALISRGLEWVAS- ---------------------------------------------------------GQD TKALQDFLLAM------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------QMCP------------------------ ----------------------------------------GNRDTYFH------------ ---------------------------------------LLQTLRRL------------- ----------------------------------------------------DRRDEATA L---------------------W------------------------RRLEAQT-----K G-L----QEGAT----------W-------------S----------------------- ------------------LPLYLESY---------------------------------- -----------------------------------------------------LSWIRPS DREALLEE----------------------------------------FQTSL------- ------------------------------------------------------------ -------PESCD-L------------------------ >ENSCJAP00000072310 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------M-----------SCQT------------------------ ----------------------TPLGS-------------------------S------- ------CLDLWREKNDRLVRQAK-VA-QN------------------------------- ------------------------------------------SGLT-------------- ------------------------LRRQ-------------------------------- --------QLAQN---------------------------------------------AL EGLRGLLHSL-------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------Q----------------------------------G--- -------------------------------------------LPAAVPVLP-------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------LELTVTCNFIILRAS- -LAQGFTEDQAQDIQRGLER----------------------------------VLETQE -QLG---PRLEQGLKEL---------------WDSV------------------------ ------------------------------------------------------------ ---------LHASILLPELLSALHRLAG-------------------------------- ------------------------------------------------------------ ---------------------------LQA------------------------------ ---------------------------ALWLSADRLGDLALL------------------ ---------------------------------------------------------LET LNG----------------------SQ--------N---GAS------------------ --EDLLL-----LLKTWSPPVEE------------------------------------- -----------------------------------------------------LDAPLTL QDAQGLKDVLL-------------------------------------------T----- ---------------AFAYRQGL--------QELITGNL----------------DRALS SLHEVASGLCPRPV------------------------------LVQVYTALGSCHRKMG ------------------------------------------------------------ ------NPQRAL-----LYLVAALKEGSAWGPPLLE------------------------ ---------------------------------------------------------ASR LYQQLGDT----------TAELESLELLVEALNVP----CS---SKA------------- --------SQFV----------------------------------IEVEL--------- ------------------------------------------------------------ -------LLPPPDPASPLHCGT-------------------------------------- -------------------------------QSQAKHVL--------------------- --------------ASRCLQT--------------------------------------- ------------------------------------------------------------ -----GRAED----------AAEHY----------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ LDL--------------------------------------------------------- ------------------------------------------------------------ -----LALLL-DSS---------------------------------------------- -------------------------------------------------------EPR-- ------------------------------------------------------------ ---------------------------------------------F------F------- -----LPRSRP-GPCMPELFLEAAVALIQAGRAQDA------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ LTVCE------------------------------------------------------- ---------------------------------------------------------ELL SRTSSL-----LPKMSRLW---------------------------EDARK--------- ------------------------------------------------------------ ---------------------------------------------------------GT- ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------K------------------- ------------------------------------------------------------ -----------ELPY--------------CPLWVSA------------------------ ------------------------------------------------------------ ------------------------------------------------------THLLQG QAWVQL--GAQKMAVSEFSRCLELLFHA-------------------------------- --------IPE-DK---------------GQ----------------------------- -----------------GA--------AS----------NCEQGCK-------------- ----------------------SDV------------------A---------------- -----------------------LQQL--------------------------------- --------------------------------------------RAAALISRGLEWVDS- ---------------------------------------------------------GQD TKALQDFLLAV------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------QMCP------------------------ ----------------------------------------GNQDTYFH------------ ---------------------------------------LLQTLRRL------------- ----------------------------------------------------NRRDEATA L---------------------W------------------------RRLEAQT-----K G-P----QEGAT----------W-------------S----------------------- ------------------LPLYLESY---------------------------------- -----------------------------------------------------LSWIHPS DCEALLEE----------------------------------------FQTSL------- ------------------------------------------------------------ -------PESCD-L------------------------ >ENSCCAP00000033040 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------M-----------FCQT------------------------ ----------------------TPLGS-------------------------S------- ------CLDLWREKNDRLVRQAK-VA-QN------------------------------- ------------------------------------------SGLT-------------- ------------------------LRRQ-------------------------------- --------QLAQD---------------------------------------------AL EGLRGLLHSL-------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------Q----------------------------------G--- -------------------------------------------LPAAVPVLP-------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------LELTVTCNFIILRAS- -LAQGFTEDQAQDIQRGLER----------------------------------VLETQE -QLG---PRLEQGLKEL---------------WDCV------------------------ ------------------------------------------------------------ ---------LRVSSLLPELLSALHRLAG-------------------------------- ------------------------------------------------------------ ---------------------------LQA------------------------------ ---------------------------ALWLSADRLGDLALL------------------ ---------------------------------------------------------LET LNG----------------------SQ--------S---GAS------------------ --EDRLL-----LLKTWSPPAEE------------------------------------- -----------------------------------------------------LDAPLTL QDAQGLKDVLL-------------------------------------------T----- ---------------AFAYRQGL--------QELITGNL----------------DRALS SLHEVASGLCPRPV------------------------------LVQVYTALGSCHRKMG ------------------------------------------------------------ ------NPQRAL-----LYLVAALKEGSAWGPPLLE------------------------ ---------------------------------------------------------ASR LYQQLGDT----------TAELESLELLVEALNVP----CS---SKA------------- --------PQFL----------------------------------IEVEL--------- ------------------------------------------------------------ -------LLPPPDPASPLHCGT-------------------------------------- -------------------------------RSQAKHVL--------------------- --------------ASRCLQT--------------------------------------- ------------------------------------------------------------ -----GRAED----------AAEHY----------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ LDL--------------------------------------------------------- ------------------------------------------------------------ -----LALLL-DSS---------------------------------------------- -------------------------------------------------------EPR-- ------------------------------------------------------------ ---------------------------------------------F------F------- -----LPRSRP-GPCMPELFLEAAVALIQAGRAQDA------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ LTLCE------------------------------------------------------- ---------------------------------------------------------ELL SRTSSL-----LPKISWLW---------------------------EDARK--------- ------------------------------------------------------------ ---------------------------------------------------------GT- ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------K------------------- ------------------------------------------------------------ -----------ELPY--------------CPLWVSA------------------------ ------------------------------------------------------------ ------------------------------------------------------THLLQG QAWVQL--GAPKMAVSEFSRCLELLFRA-------------------------------- --------IPE-DK---------------GQ----------------------------- -----------------GA--------AS----------NCEQGCK-------------- ----------------------SDA------------------A---------------- -----------------------LQQL--------------------------------- --------------------------------------------RAAALISRGLEWVAS- ---------------------------------------------------------GQD TKALQDFLLAV------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------QICP------------------------ ----------------------------------------GNRDTYFH------------ ---------------------------------------LLQTLRRL------------- ----------------------------------------------------DRRDEATA L---------------------W------------------------RRLEAQT-----K G-P----QEGAI----------W-------------S----------------------- ------------------LPLYLESY---------------------------------- -----------------------------------------------------LSWIGPS DREALLEE----------------------------------------FQTSL------- ------------------------------------------------------------ -------LESCD-L------------------------ >ENSMFAP00000007563 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------M-----------SRQT------------------------ ----------------------TSVGS-------------------------S------- ------CLDLWREKNDRLVRQAK-VA-QN------------------------------- ------------------------------------------SGLT-------------- ------------------------LRRQ-------------------------------- --------QLAQD---------------------------------------------AL EGLRGLLHSL-------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------Q----------------------------------G--- -------------------------------------------LPAAVPVLP-------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------LELTVICNFIILRAS- -LAQGFTEDQAQDIQRGLER----------------------------------VLETQE -QRG---PRLEQGLREL---------------WDSA------------------------ ------------------------------------------------------------ ---------LRASCLLPELLSALHRLAG-------------------------------- ------------------------------------------------------------ ---------------------------LQA------------------------------ ---------------------------ALWLSADRLGDLALL------------------ ---------------------------------------------------------LET LND----------------------SQ--------S---GAS------------------ --EDLLL-----LLKTWSPPAEE------------------------------------- -----------------------------------------------------LDAPLTL QDAQGLKDVLL-------------------------------------------T----- ---------------AFAYRRGL--------QELITGNP----------------EKALS SLHEVASGLCPRPV------------------------------LVQVYTALGSCHRKMG ------------------------------------------------------------ ------NPQRAL-----LYLVAALKEGSAWGPPLLE------------------------ ---------------------------------------------------------ASR LYQQLGDT----------TAELESLELLVEALNVP----YS---SKA------------- --------PPFL----------------------------------IEVEL--------- ------------------------------------------------------------ -------LLPPPDLASPLHCGT-------------------------------------- -------------------------------QSQAKHVL--------------------- --------------ASRCLQT--------------------------------------- ------------------------------------------------------------ -----GRAED----------AAEHY----------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ LDL--------------------------------------------------------- ------------------------------------------------------------ -----LALLL-DSS---------------------------------------------- -------------------------------------------------------EPR-- ------------------------------------------------------------ ---------------------------------------------F------S------- -----PPPSPP-GPCMPEVFLEAAVALIQAGRAQDA------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ LTLCE------------------------------------------------------- ---------------------------------------------------------ELL SRTSSL-----LPKMSRLW---------------------------ENARK--------- ------------------------------------------------------------ ---------------------------------------------------------GT- ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------K------------------- ------------------------------------------------------------ -----------ELPY--------------CPLWVSA------------------------ ------------------------------------------------------------ ------------------------------------------------------THLLQG QAWVQL--GAQKVAISEFSRCLELLFRT-------------------------------- --------TPE-EK---------------EQ----------------------------- -----------------GA--------AS----------NGEQGCK-------------- ----------------------SDV------------------A---------------- -----------------------LQQL--------------------------------- --------------------------------------------RAAALISRGLEWVAS- ---------------------------------------------------------GQD TKALQDFLLGV------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------QMCP------------------------ ----------------------------------------GNRDTYFH------------ ---------------------------------------LLQTLKRL------------- ----------------------------------------------------DRRDEATA L---------------------W------------------------WRLEAQT-----K G-P----QEDAT----------W-------------S----------------------- ------------------LPLYLESY---------------------------------- -----------------------------------------------------LSWIRPS DRDAFLEE----------------------------------------FRTSL------- ------------------------------------------------------------ -------PKSCD-L------------------------ >ENSCATP00000011352 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------M-----------SRQT------------------------ ----------------------TSVGS-------------------------S------- ------CLDLWREKNDRLVRQAK-VA-QN------------------------------- ------------------------------------------SGLT-------------- ------------------------LRRQ-------------------------------- --------QLAQD---------------------------------------------AL EGLRGLLHSL-------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------Q----------------------------------G--- -------------------------------------------LPAAVPVLP-------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------LELTVICNFIILRAS- -LAQGFTEDQAQDIQRGLER----------------------------------VLETQE -QRG---PRLEQGLREL---------------WDSA------------------------ ------------------------------------------------------------ ---------LRASCLLPELLSALHRLAG-------------------------------- ------------------------------------------------------------ ---------------------------LQA------------------------------ ---------------------------ALWLSADRLGDLALL------------------ ---------------------------------------------------------LET LND----------------------SQ--------S---GAS------------------ --EDLLL-----LLKTWSPPAEE------------------------------------- -----------------------------------------------------LDAPLTL QDAQGLKDVLL-------------------------------------------T----- ---------------AFAYRRGL--------QELITGNP----------------EKALS SLHEVASGLCPRPV------------------------------LVQVYTALGSCHRKMG ------------------------------------------------------------ ------NPQRAL-----LYLVAALKEGSAWGPPLLE------------------------ ---------------------------------------------------------ASR LYQQLGDT----------TAELESLELLVEALNVP----YS---SKA------------- --------PPFL----------------------------------IEVEL--------- ------------------------------------------------------------ -------LLPPPDLASPLHCGT-------------------------------------- -------------------------------QSQAKHVL--------------------- --------------ASRCLQT--------------------------------------- ------------------------------------------------------------ -----GRAED----------AAEHY----------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ LDL--------------------------------------------------------- ------------------------------------------------------------ -----LALLL-DSS---------------------------------------------- -------------------------------------------------------EPR-- ------------------------------------------------------------ ---------------------------------------------F------S------- -----PPPSPP-GPCMPEVFLEAAVALIQAGRAQDA------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ LTLCE------------------------------------------------------- ---------------------------------------------------------ELL SRTSSL-----LPKMSRLW---------------------------ENARK--------- ------------------------------------------------------------ ---------------------------------------------------------GT- ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------K------------------- ------------------------------------------------------------ -----------ELPY--------------CPLWVSA------------------------ ------------------------------------------------------------ ------------------------------------------------------THLLQG QAWVQL--GAQKVAISEFSRCLELLFRT-------------------------------- --------TPE-EK---------------EQ----------------------------- -----------------GA--------AS----------NGEQGCK-------------- ----------------------SDV------------------A---------------- -----------------------LQQL--------------------------------- --------------------------------------------RAAALISRGLEWVAS- ---------------------------------------------------------GQD TKALQDFLLGV------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------QMCP------------------------ ----------------------------------------GNRDTYFH------------ ---------------------------------------LLQTLKRL------------- ----------------------------------------------------DRRDEATA L---------------------W------------------------WRLEAPT-----K G-P----QEDAT----------W-------------S----------------------- ------------------LPLYLESY---------------------------------- -----------------------------------------------------LSWIRPS DRDAFLEE----------------------------------------FRTSL------- ------------------------------------------------------------ -------PKSCD-L------------------------ >ENSTGEP00000010695 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------M-----------SRQT------------------------ ----------------------TSVGS-------------------------S------- ------CLDLWREKNDRLVRQAK-VA-QN------------------------------- ------------------------------------------SGLT-------------- ------------------------LRRQ-------------------------------- --------QLAQD---------------------------------------------AL EGLRGLLHSL-------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------Q----------------------------------G--- -------------------------------------------LPAAVPVLP-------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------LELTVICNFIILRAS- -LAQGFTEDQAQDIQRGLER----------------------------------VLETQE -QRG---PRLEQGLREL---------------WDSA------------------------ ------------------------------------------------------------ ---------LRASCLLPELLSALHRLAG-------------------------------- ------------------------------------------------------------ ---------------------------LQA------------------------------ ---------------------------ALWLSADRLGDLALL------------------ ---------------------------------------------------------LET LND----------------------SQ--------S---GAS------------------ --EDLLL-----LLKTWSPPAEE------------------------------------- -----------------------------------------------------LDAPLTL QDAQGLKDVLL-------------------------------------------T----- ---------------AFAYRRGL--------QELITGNP----------------EKALS SLHEVASGLCPRPV------------------------------LVQVYTALGSCHRKMG ------------------------------------------------------------ ------NPQRAL-----LYLVAALKEGSAWGPPLLE------------------------ ---------------------------------------------------------ASR LYQQLGDT----------TAELESLELLVEALNVP----YS---SKT------------- --------PPFL----------------------------------IEVEL--------- ------------------------------------------------------------ -------LLPPPDLASPLHCGT-------------------------------------- -------------------------------QSQAKHVL--------------------- --------------ASRCLQM--------------------------------------- ------------------------------------------------------------ -----GRAED----------AAEHY----------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ LDL--------------------------------------------------------- ------------------------------------------------------------ -----LALLL-DSS---------------------------------------------- -------------------------------------------------------EPR-- ------------------------------------------------------------ ---------------------------------------------F------S------- -----PPPSPP-GPCMPEVFLEAAVALIQAGRAQDA------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ LTLCE------------------------------------------------------- ---------------------------------------------------------ELL RRTSSL-----LPKMSRLW---------------------------ENARK--------- ------------------------------------------------------------ ---------------------------------------------------------GT- ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------K------------------- ------------------------------------------------------------ -----------ELPY--------------CPLWVSA------------------------ ------------------------------------------------------------ ------------------------------------------------------THLLQG QAWVQL--GAQKVAISEFSRCLELLFRT-------------------------------- --------TPE-EK---------------EK----------------------------- -----------------GA--------AS----------NGEQGCK-------------- ----------------------SDV------------------A---------------- -----------------------LQQL--------------------------------- --------------------------------------------RAAALISRGLEWVAS- ---------------------------------------------------------GQD TKALQDFLLGV------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------QMCP------------------------ ----------------------------------------GNRDTYFH------------ ---------------------------------------LLQTLKRL------------- ----------------------------------------------------DRRDEATA L---------------------W------------------------WRLEAQT-----K G-P----QEDAT----------W-------------S----------------------- ------------------LPLYLESY---------------------------------- -----------------------------------------------------LSWIRPS DRDAFLEE----------------------------------------FRTSL------- ------------------------------------------------------------ -------PKSCD-L------------------------ >ENSPANP00000019118 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------M-----------SRQT------------------------ ----------------------TSVGS-------------------------S------- ------CLDLWREKNDRLVRQAK-VA-QN------------------------------- ------------------------------------------SGLT-------------- ------------------------LRRQ-------------------------------- --------QLAQD---------------------------------------------AL EGLRGLLHSL-------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------Q----------------------------------G--- -------------------------------------------LPAAVPVLP-------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------LELTVICNFIILRAS- -LAQGFTEDQAQDIQRGLER----------------------------------VLETQE -QRG---PRLEQGLREL---------------WDSA------------------------ ------------------------------------------------------------ ---------LRASCLLPELLSALHRLAG-------------------------------- ------------------------------------------------------------ ---------------------------LQA------------------------------ ---------------------------ALWLSADRLGDLALL------------------ ---------------------------------------------------------LET LND----------------------SQ--------S---GAS------------------ --EDLLL-----LLKTWSPPAEE------------------------------------- -----------------------------------------------------LDAPLTL QDAQGLKDVLL-------------------------------------------T----- ---------------AFAYRRGL--------QELITGNP----------------EKALS SLHEVASGLCPRPV------------------------------LVQVYTALGSCHRKMG ------------------------------------------------------------ ------NPQRAL-----LYLVAALKEGSAWGPPLLE------------------------ ---------------------------------------------------------ASR LYQQLGDT----------TAELESLELLVEALNVP----YS---SKA------------- --------PPFL----------------------------------IEVEL--------- ------------------------------------------------------------ -------LLPPPDLASPLHCGT-------------------------------------- -------------------------------QSQAKHVL--------------------- --------------ASRCLQM--------------------------------------- ------------------------------------------------------------ -----GRAED----------AAEHY----------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ LDL--------------------------------------------------------- ------------------------------------------------------------ -----LALLL-DSS---------------------------------------------- -------------------------------------------------------EPR-- ------------------------------------------------------------ ---------------------------------------------F------S------- -----PPPSPP-GPCMPEVFLEAAVALIQAGRAQDA------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ LTLCE------------------------------------------------------- ---------------------------------------------------------ELL RRTSSL-----LPKMSRLW---------------------------ENARK--------- ------------------------------------------------------------ ---------------------------------------------------------GT- ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------K------------------- ------------------------------------------------------------ -----------ELPY--------------CPLWVSA------------------------ ------------------------------------------------------------ ------------------------------------------------------THLLQG QAWVQL--GAQKVAISEFSRCLELLFRT-------------------------------- --------TPE-EK---------------EQ----------------------------- -----------------GA--------AS----------NGEQGCK-------------- ----------------------SDV------------------A---------------- -----------------------LQQL--------------------------------- --------------------------------------------RAAALISRGLEWVAS- ---------------------------------------------------------GQD TKALQDFLLGV------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------QMCP------------------------ ----------------------------------------GNRDTYFH------------ ---------------------------------------LLQTLKRL------------- ----------------------------------------------------DRRDEATA L---------------------W------------------------WRLEAQT-----K G-P----QEDAT----------W-------------S----------------------- ------------------LPLYLESY---------------------------------- -----------------------------------------------------LSWIRPS DRDAFLEE----------------------------------------FRTSL------- ------------------------------------------------------------ -------PKSCD-L------------------------ >ENSMNEP00000038617 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------M-----------SRQT------------------------ ----------------------TSVGS-------------------------S------- ------CLDLWREKNDRLVRQAK-VA-QN------------------------------- ------------------------------------------SGLT-------------- ------------------------LRRQ-------------------------------- --------QLAQD---------------------------------------------AL EGLRGLLHSL-------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------Q----------------------------------G--- -------------------------------------------LPAAVPVLP-------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------LELTVICNFIILRAS- -LAQGFTEDQAQDIQRGLER----------------------------------VLETQE -QRG---PRLEQGLREL---------------WDSA------------------------ ------------------------------------------------------------ ---------LRASCLLPELLSALHLLAG-------------------------------- ------------------------------------------------------------ ---------------------------LQA------------------------------ ---------------------------ALWLSADRLGDLALL------------------ ---------------------------------------------------------LET LND----------------------SQ--------S---GAS------------------ --EDLLL-----LLKTWSPPAEE------------------------------------- -----------------------------------------------------LDAPLTL QDAQGLKDVLL-------------------------------------------T----- ---------------AFAYRRGL--------QELITGNP----------------EKALS SLHEVASGLCPRPV------------------------------LVQVYTALGSCHRKMG ------------------------------------------------------------ ------NPQRAL-----LYLVAALKEGSAWGPPLLE------------------------ ---------------------------------------------------------ASR LYQQLGDT----------TAELESLELLVEALNVP----YS---SKA------------- --------PPFL----------------------------------IEVEL--------- ------------------------------------------------------------ -------LLPPPDLASPLHCGT-------------------------------------- -------------------------------QSQAKHVL--------------------- --------------ASRCLQT--------------------------------------- ------------------------------------------------------------ -----GRAED----------AAEHY----------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ LDL--------------------------------------------------------- ------------------------------------------------------------ -----LALLL-DSS---------------------------------------------- -------------------------------------------------------EPR-- ------------------------------------------------------------ ---------------------------------------------F------S------- -----PPPSPP-GPCMPEVFLEAAVALIQAGRAQDA------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ LTLCE------------------------------------------------------- ---------------------------------------------------------ELL SRTSSL-----LPKMSWLW---------------------------ENARK--------- ------------------------------------------------------------ ---------------------------------------------------------GT- ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------K------------------- ------------------------------------------------------------ -----------ELPY--------------CPLWVSA------------------------ ------------------------------------------------------------ ------------------------------------------------------THLLQG QAWVQL--GAQKVAISEFSRCLELLFRT-------------------------------- --------TPE-EK---------------EQ----------------------------- -----------------GA--------AS----------NGEQGCK-------------- ----------------------SDV------------------A---------------- -----------------------LQQL--------------------------------- --------------------------------------------RAAALISRGLEWVAS- ---------------------------------------------------------GQD TKALQDFLLGV------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------QMCP------------------------ ----------------------------------------GNRDTYFH------------ ---------------------------------------LLQTLKRL------------- ----------------------------------------------------DRRDEATA L---------------------W------------------------WRLEAQT-----K G-P----QEDAT----------W-------------S----------------------- ------------------LPLYLESY---------------------------------- -----------------------------------------------------LSWIRPS DRDAFLEE----------------------------------------FRTSL------- ------------------------------------------------------------ -------PKSCD-L------------------------ >ENSMLEP00000005135 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------M-----------SRQT------------------------ ----------------------TSVGS-------------------------S------- ------CLELWREKNDRLVRQAK-VA-QN------------------------------- ------------------------------------------SGLT-------------- ------------------------LRRQ-------------------------------- --------QLAQD---------------------------------------------AL EGLRGLLHSL-------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------Q----------------------------------G--- -------------------------------------------LPAAVPVLP-------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------LELTVICNFIILRAS- -LAQGFTEDQAQDIQRGLER----------------------------------VLETQE -QRG---PRLEQGLREL---------------WDSA------------------------ ------------------------------------------------------------ ---------LRASCLLPELLSPLHRLAG-------------------------------- ------------------------------------------------------------ ---------------------------LQA------------------------------ ---------------------------ALWLSADRLGDLALL------------------ ---------------------------------------------------------LET LND----------------------SQ--------S---GAS------------------ --EDLLL-----LLKTWSPPAEE------------------------------------- -----------------------------------------------------LDAPLTL QDAQGLKDVLL-------------------------------------------T----- ---------------AFAYRRGL--------QELITGNP----------------EKALS SLHEVASGLCPRPV------------------------------LVQVYTALGSCHRKMG ------------------------------------------------------------ ------NPQRAL-----LYLVAALKEGSAWGPPLLE------------------------ ---------------------------------------------------------ASR LYQQLGDT----------TAELESLELLVEALNVP----YS---SKA------------- --------PPLL----------------------------------IEVEL--------- ------------------------------------------------------------ -------LLPPPDLASPLHCGT-------------------------------------- -------------------------------QSQAKHVL--------------------- --------------ASRCLQT--------------------------------------- ------------------------------------------------------------ -----GRAED----------AAEHY----------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ LDL--------------------------------------------------------- ------------------------------------------------------------ -----LALLL-DSS---------------------------------------------- -------------------------------------------------------EPR-- ------------------------------------------------------------ ---------------------------------------------F------S------- -----PPPSPP-GPCMPEVFLEAAVALIQAGRAQDA------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ LTLCE------------------------------------------------------- ---------------------------------------------------------ELL SRTSSL-----LPKMSRLW---------------------------ENARK--------- ------------------------------------------------------------ ---------------------------------------------------------GT- ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------K------------------- ------------------------------------------------------------ -----------ELPY--------------CPLWVSA------------------------ ------------------------------------------------------------ ------------------------------------------------------THLLQG QAWVQL--GAQKVAISEFSRCLELLFRT-------------------------------- --------TPQ-EK---------------EQ----------------------------- -----------------GA--------AS----------NGEQGCK-------------- ----------------------SDV------------------A---------------- -----------------------LQQL--------------------------------- --------------------------------------------RAAALISRGLEWVAS- ---------------------------------------------------------GQD TKALQDFLLGV------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------QMCP------------------------ ----------------------------------------GNRDTYFH------------ ---------------------------------------LLQTLKRL------------- ----------------------------------------------------DRRDEATA L---------------------W------------------------WRLEAQT-----K G-P----QEDAT----------W-------------S----------------------- ------------------LPLYLESY---------------------------------- -----------------------------------------------------LSWIRPS DRDAFLEE----------------------------------------FRTSL------- ------------------------------------------------------------ -------PKSCD-L------------------------ >ENSCSAP00000006494 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------M-----------SRQT------------------------ ----------------------TSVGS-------------------------N------- ------CLDLWREKNDRLVRQAK-VA-QN------------------------------- ------------------------------------------SGLT-------------- ------------------------LRRL-------------------------------- --------QLAQD---------------------------------------------AL EGLRGLLHSL-------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------Q----------------------------------G--- -------------------------------------------LPAAVPVLP-------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------LELTVICNFIILRAS- -LAQGFTEDQAQDIQRGLER----------------------------------VLETQE -QQG---PRLEQGLREL---------------WDSA------------------------ ------------------------------------------------------------ ---------LRASCLLPELLSALHRLAG-------------------------------- ------------------------------------------------------------ ---------------------------LQA------------------------------ ---------------------------ALWLSADRLGDLALL------------------ ---------------------------------------------------------LET LND----------------------SQ--------S---GAS------------------ --EDLLL-----LLKTWSPPAEE------------------------------------- -----------------------------------------------------LDAPLTL QDAQGLKDVLL-------------------------------------------T----- ---------------AFAYRRGL--------QELITGNP----------------DKALS SLHEVASGLCPRPV------------------------------LVQVYTALGSCHRKMG ------------------------------------------------------------ ------NPQRAL-----LYLVAALKEGSAWGPPLLE------------------------ ---------------------------------------------------------ASR LYRQLGDT----------TAELESLELLVEALNVP----YS---SKA------------- --------PPFL----------------------------------IEVEL--------- ------------------------------------------------------------ -------LLPPPDLASPLHCGT-------------------------------------- -------------------------------QSQAKHVL--------------------- --------------ASRCLQT--------------------------------------- ------------------------------------------------------------ -----GRAED----------AAEHY----------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ LDL--------------------------------------------------------- ------------------------------------------------------------ -----LALLL-DSS---------------------------------------------- -------------------------------------------------------EPR-- ------------------------------------------------------------ ---------------------------------------------F------S------- -----PPPSPP-GPCMPEVFLEAAVALIQAGRAQDA------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ LTLCE------------------------------------------------------- ---------------------------------------------------------ELF SRTSSL-----LPKMSRLW---------------------------EDARK--------- ------------------------------------------------------------ ---------------------------------------------------------GT- ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------K------------------- ------------------------------------------------------------ -----------ELPY--------------CPLWVSA------------------------ ------------------------------------------------------------ ------------------------------------------------------THLLQG QAWVQL--GAQKVAISEFSRCLELLFRT-------------------------------- --------TPE-EK---------------EQ----------------------------- -----------------GA--------AS----------NGEQGCK-------------- ----------------------SDV------------------A---------------- -----------------------LQQL--------------------------------- --------------------------------------------RAAALISRGLEWVAS- ---------------------------------------------------------GQD TKALQDFLLGV------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------QMCP------------------------ ----------------------------------------GNRDTYFH------------ ---------------------------------------LLQTLKRL------------- ----------------------------------------------------DRRDEATA L---------------------W------------------------WRLEAQT-----E G-P----QEDAT----------W-------------S----------------------- ------------------LPLYLESY---------------------------------- -----------------------------------------------------LSWIRPS DRDAFLEE----------------------------------------FRTSL------- ------------------------------------------------------------ -------PKSCD-L------------------------ >ENSPTEP00000016850 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------M-----------SRQT------------------------ ----------------------TSVGS-------------------------S------- ------CLDLWREKNDRLVRQAK-VA-QN------------------------------- ------------------------------------------SDLT-------------- ------------------------LRRR-------------------------------- --------QLAQD---------------------------------------------AL EGLRGLLHSL-------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------Q----------------------------------G--- -------------------------------------------LPAAVPVLP-------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------LELTVICNFIILRAS- -LAQGFTEDQAQDIQRGLER----------------------------------VLETQE -QQG---PRLEQGLREL---------------WDSA------------------------ ------------------------------------------------------------ ---------LRASCLLPELLSALHRLAG-------------------------------- ------------------------------------------------------------ ---------------------------LQA------------------------------ ---------------------------ALWLSADRLGDLALL------------------ ---------------------------------------------------------LET LND----------------------SQ--------S---GAS------------------ --EDLLL-----LLKTWSPPSEE------------------------------------- -----------------------------------------------------LDAPLTL QDAQGLKDVLL-------------------------------------------T----- ---------------AFAYRRGL--------QELITGNP----------------EKALS SLHEVASGPCPRPV------------------------------LVQVYTALGSCHRKMG ------------------------------------------------------------ ------NPQRAL-----LYLVAALKEGSAWGPPLLE------------------------ ---------------------------------------------------------ASK LYQQLGDT----------TAELESLELLVEALNVP----YS---SKS------------- --------PQFL----------------------------------IEVEL--------- ------------------------------------------------------------ -------LLPPPDLASPLHCGT-------------------------------------- -------------------------------QSQAKHIL--------------------- --------------ASRCLQT--------------------------------------- ------------------------------------------------------------ -----GRAED----------AAEHY----------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ LDL--------------------------------------------------------- ------------------------------------------------------------ -----LALLL-DSS---------------------------------------------- -------------------------------------------------------EPR-- ------------------------------------------------------------ ---------------------------------------------F------S------- -----PPPSPP-GPCMPEVFLEAAVALIQAGRAQDA------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ LTLCE------------------------------------------------------- ---------------------------------------------------------ELL SRTSSL-----LPKMSRLW---------------------------EDARK--------- ------------------------------------------------------------ ---------------------------------------------------------GT- ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------K------------------- ------------------------------------------------------------ -----------ELPY--------------CPLWVSA------------------------ ------------------------------------------------------------ ------------------------------------------------------THLLQG QAWVQL--GAQKVAISEFSRCLELLFRA-------------------------------- --------TPE-EK---------------EK----------------------------- -----------------GA--------AS----------NCEQGCK-------------- ----------------------SDV------------------A---------------- -----------------------LQQL--------------------------------- --------------------------------------------RAAALISRGLEWVAS- ---------------------------------------------------------GQD TKALQDFLLGV------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------QMCP------------------------ ----------------------------------------GNGDTYFH------------ ---------------------------------------LLQTLKRL------------- ----------------------------------------------------DRRDEATA L---------------------W------------------------WRLEAQT-----K G-P----QEDAT----------W-------------S----------------------- ------------------LPLYLESY---------------------------------- -----------------------------------------------------LSWIRPS DRDAFLEE----------------------------------------FRTSL------- ------------------------------------------------------------ -------PKSCD-L------------------------ >ENSRBIP00000018766 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------M-----------SRQT------------------------ ----------------------TSVGS-------------------------S------- ------CLDLWREKNDRLVRQAK-VA-QN------------------------------- ------------------------------------------SDLT-------------- ------------------------LRRR-------------------------------- --------QLAQD---------------------------------------------AL EGLRGLLHSL-------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------Q----------------------------------G--- -------------------------------------------LPAAVPVLP-------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------LELTVICNFIILRAS- -LAQGFTEDQAQDIQRGLER----------------------------------VLETQE -QRG---PRLEQGLREL---------------WDSA------------------------ ------------------------------------------------------------ ---------LRASCLLPELLSALHRLAG-------------------------------- ------------------------------------------------------------ ---------------------------LQA------------------------------ ---------------------------ALWLSADRLGDLALL------------------ ---------------------------------------------------------LET LND----------------------SQ--------S---GAS------------------ --EDLLL-----LLKTWSPPAEE------------------------------------- -----------------------------------------------------LDAPLTL QDAQGLKDVLL-------------------------------------------T----- ---------------AFTYRRGL--------QELITGNP----------------DKALS SLHEVASGLCPRPV------------------------------LVQVYTALGSCHRKMG ------------------------------------------------------------ ------NPQRAL-----LYLVAALKEGSAWGPPLLE------------------------ ---------------------------------------------------------ASR LYQQLGDT----------PAELESLELLVEALNVP----YS---SKA------------- --------PQFL----------------------------------IEVEL--------- ------------------------------------------------------------ -------LLPPPDLASPLHCGT-------------------------------------- -------------------------------QSQAKHIL--------------------- --------------ASRCLQT--------------------------------------- ------------------------------------------------------------ -----GRAED----------AAEHY----------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ LDL--------------------------------------------------------- ------------------------------------------------------------ -----LALLL-DSS---------------------------------------------- -------------------------------------------------------EPR-- ------------------------------------------------------------ ---------------------------------------------F------S------- -----PPPSPP-GPCMPEVFLEAAVALIQAGRAQDA------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ LTLCE------------------------------------------------------- ---------------------------------------------------------ELL SRTSSL-----LPKMSRLW---------------------------EDARK--------- ------------------------------------------------------------ ---------------------------------------------------------GT- ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------K------------------- ------------------------------------------------------------ -----------ELPY--------------CPLWVSA------------------------ ------------------------------------------------------------ ------------------------------------------------------THLLQG QAWVQL--GAQKVAISEFSRCLELLFRT-------------------------------- --------TPE-EK---------------EQ----------------------------- -----------------GA--------AS----------NCEQGCK-------------- ----------------------SDV------------------A---------------- -----------------------LQQL--------------------------------- --------------------------------------------RAAALISRGLEWVAS- ---------------------------------------------------------GQD TKALQDFLLGV------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------QMCP------------------------ ----------------------------------------GNGDTYFH------------ ---------------------------------------LLQTLKRL------------- ----------------------------------------------------DRRDEATA L---------------------W------------------------WRLEAQT-----K G-P----QEDAM----------W-------------S----------------------- ------------------LPLYLESY---------------------------------- -----------------------------------------------------LSWIRPS DRDAFLEE----------------------------------------FRTSL------- ------------------------------------------------------------ -------PKSCD-L------------------------ >ENSRROP00000036166 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------M-----------SRQT------------------------ ----------------------TSVGS-------------------------S------- ------CLDLWREKNDRLVRQAK-VA-QN------------------------------- ------------------------------------------SDLT-------------- ------------------------LRRR-------------------------------- --------QLAQD---------------------------------------------AL EGLRGLLHSL-------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------Q----------------------------------G--- -------------------------------------------LPAAVPVLP-------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------LELTVICNFIILRAS- -LAQGFTEDQAQDIQRGLER----------------------------------VLETQE -QRG---PRLEQGLREL---------------WDSA------------------------ ------------------------------------------------------------ ---------LRASCLLPELLSALHRLAG-------------------------------- ------------------------------------------------------------ ---------------------------LQA------------------------------ ---------------------------ALWLSADRLGDLALL------------------ ---------------------------------------------------------LET LND----------------------SQ--------S---GAS------------------ --EDLLL-----LLKTWSPPAEE------------------------------------- -----------------------------------------------------LDAPLTL QDAQGLKDVLL-------------------------------------------T----- ---------------AFAYRRGL--------QELITGNP----------------DKALS SLHEVASGLCPRPV------------------------------LVQVYTALGSCHRKMG ------------------------------------------------------------ ------NPQRAL-----LYLVAALKEGSAWGPPLLE------------------------ ---------------------------------------------------------ASR LYQQLGDT----------PAELESLELLVEALNVP----YS---SKA------------- --------PQFL----------------------------------IEVEL--------- ------------------------------------------------------------ -------LLPPPDLASPLHCGT-------------------------------------- -------------------------------QSQAKHIL--------------------- --------------ASRCLQT--------------------------------------- ------------------------------------------------------------ -----GRAED----------AAEHY----------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ LDL--------------------------------------------------------- ------------------------------------------------------------ -----LALLL-DSS---------------------------------------------- -------------------------------------------------------EPR-- ------------------------------------------------------------ ---------------------------------------------F------S------- -----PPPSPP-GPCMPEVFLEAAVALIQAGRAQDA------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ LTLCE------------------------------------------------------- ---------------------------------------------------------ELL SRTSSL-----LPKMSRLW---------------------------EDARK--------- ------------------------------------------------------------ ---------------------------------------------------------GT- ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------K------------------- ------------------------------------------------------------ -----------ELPY--------------CPLWVSA------------------------ ------------------------------------------------------------ ------------------------------------------------------THLLQG QAWVQL--GAQKVAISEFSRCLELLFRT-------------------------------- --------TPE-EK---------------EQ----------------------------- -----------------GA--------AS----------NCEQGCK-------------- ----------------------SDV------------------A---------------- -----------------------LQQL--------------------------------- --------------------------------------------RAAALISRGLEWVAS- ---------------------------------------------------------GQD TKALQDFLLGV------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------QMCP------------------------ ----------------------------------------GNGDTYFH------------ ---------------------------------------LLQTLKRL------------- ----------------------------------------------------DRRDEATA L---------------------W------------------------WRLEAQT-----K G-P----QEDAM----------W-------------S----------------------- ------------------LPLYLESY---------------------------------- -----------------------------------------------------LSWIRPS DRDAFLEE----------------------------------------FRTSL------- ------------------------------------------------------------ -------PKSCD-L------------------------ >ENSCANP00000022651 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------M-----------SRQT------------------------ ----------------------TSVDS-------------------------S------- ------CLDLWREKNDRLVRQAK-VA-QN------------------------------- ------------------------------------------SDLT-------------- ------------------------LRRR-------------------------------- --------QVAQD---------------------------------------------AL EGLRGLLHSL-------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------Q----------------------------------G--- -------------------------------------------LPAAVPVLP-------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------LELTVICNFIILRAS- -LAQGFTEDQAQDIQRGLER----------------------------------VLETQE -QQG---PRLEQGLREL---------------WDSA------------------------ ------------------------------------------------------------ ---------LRASCLLPELLSALHRLAG-------------------------------- ------------------------------------------------------------ ---------------------------LQA------------------------------ ---------------------------ALWLSADRLGDLALL------------------ ---------------------------------------------------------LET LND----------------------SQ--------S---GAS------------------ --EDLLL-----LLKTWSPPSEE------------------------------------- -----------------------------------------------------LDAPLTL QDAQGLKDVLL-------------------------------------------T----- ---------------AFAYRRGL--------QELITGNP----------------DKALS SLHEVASGLCPRPV------------------------------LVQVYTALGSCHRKMG ------------------------------------------------------------ ------NPQRAL-----LYLVAALKEGSAWGPPLLE------------------------ ---------------------------------------------------------ASR LYQQLGDT----------TAELESLELLVEALNVP----YS---SKS------------- --------PQFL----------------------------------IEVEL--------- ------------------------------------------------------------ -------LLPPPDLASPLHCGT-------------------------------------- -------------------------------RSQAKHIL--------------------- --------------ASRCLQT--------------------------------------- ------------------------------------------------------------ -----GRAED----------AAEHY----------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ LDL--------------------------------------------------------- ------------------------------------------------------------ -----LALLL-DSS---------------------------------------------- -------------------------------------------------------EPR-- ------------------------------------------------------------ ---------------------------------------------F------S------- -----PPPSPP-GPCMPEVFLEAAVALIQAGRAQDA------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ LTVCE------------------------------------------------------- ---------------------------------------------------------ELL SRTSSL-----LPKMSRLW---------------------------EDARK--------- ------------------------------------------------------------ ---------------------------------------------------------GT- ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------K------------------- ------------------------------------------------------------ -----------ELPY--------------CPLWVSA------------------------ ------------------------------------------------------------ ------------------------------------------------------THLLQG QAWVQL--GAQKVAISEFSRCLELLFRT-------------------------------- --------TPE-EK---------------EQ----------------------------- -----------------GA--------AS----------NREQGCK-------------- ----------------------SDV------------------A---------------- -----------------------LQQL--------------------------------- --------------------------------------------RAAALISRGLEWVAS- ---------------------------------------------------------GQD TKALQDFLLGV------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------QMCP------------------------ ----------------------------------------GNGDTYFH------------ ---------------------------------------LLQTLKRL------------- ----------------------------------------------------DRRDEATA L---------------------W------------------------WRLEAQT-----K G-P----QEDAT----------W-------------S----------------------- ------------------LPLYLESY---------------------------------- -----------------------------------------------------LSWIRPS DRDAFLEE----------------------------------------FQTSL------- ------------------------------------------------------------ -------PKSCD-L------------------------ >ENSPTRP00000035752 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------M-----------SRQT------------------------ ----------------------TSVGS-------------------------S------- ------CLDLWREKNDRLVRQAK-VA-QN------------------------------- ------------------------------------------SGLT-------------- ------------------------LRRQ-------------------------------- --------QLAQD---------------------------------------------AL EGLRGLLHSL-------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------Q----------------------------------G--- -------------------------------------------LPAAVPVLP-------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------LELTVTCNFIILRAS- -LAQGFTEDQAQDIQRSLER----------------------------------VLETQE -QRG---PRLEQGLREL---------------WDSV------------------------ ------------------------------------------------------------ ---------LRASCLLPELLSALHRLVG-------------------------------- ------------------------------------------------------------ ---------------------------LQA------------------------------ ---------------------------ALWLSADRLGDLALL------------------ ---------------------------------------------------------LET LNG----------------------SQ--------S---GAS------------------ --KDLLL-----LLKTWSPPAEE------------------------------------- -----------------------------------------------------LDAPLTL QDAQGLKDVLL-------------------------------------------T----- ---------------AFAYRQGL--------QELITGNP----------------DKALS SLHEVASGLCPRPV------------------------------LVQVYTALGSCHRKMG ------------------------------------------------------------ ------NPQRAL-----LYLVAALKEGSAWGPPLLE------------------------ ---------------------------------------------------------ASR LYQQLGDT----------TAELESLELLVEALNVP----CS---SKA------------- --------PQFL----------------------------------IEVEL--------- ------------------------------------------------------------ -------LLPPPDLASPLHCGT-------------------------------------- -------------------------------QSQTKHIL--------------------- --------------ASRCLQT--------------------------------------- ------------------------------------------------------------ -----GRAGD----------AAEHY----------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ LDL--------------------------------------------------------- ------------------------------------------------------------ -----LALLL-DSS---------------------------------------------- -------------------------------------------------------EPR-- ------------------------------------------------------------ ---------------------------------------------F------S------- -----PPPSPP-GPCMPEVFLEAAVALIQAGRAQDA------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ LTLCE------------------------------------------------------- ---------------------------------------------------------ELL SRTSSL-----LPKMSRLW---------------------------EDARK--------- ------------------------------------------------------------ ---------------------------------------------------------GT- ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------K------------------- ------------------------------------------------------------ -----------ELPY--------------CPLWVSA------------------------ ------------------------------------------------------------ ------------------------------------------------------THLLQG QAWVQL--GAQKVAISEFSRCLELLFQA-------------------------------- --------TPE-EK---------------EQ----------------------------- -----------------GA--------AF----------NCEQGCK-------------- ----------------------SDA------------------A---------------- -----------------------LQQL--------------------------------- --------------------------------------------RAAALISRGLEWVAS- ---------------------------------------------------------GQD TKALQDFLLGV------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------QMCP------------------------ ----------------------------------------GNRDTYFH------------ ---------------------------------------LLQTLKRL------------- ----------------------------------------------------DRRDEATA L---------------------W------------------------WRLEAQT-----K G-S----HEDAL----------W-------------S----------------------- ------------------LPLYLESY---------------------------------- -----------------------------------------------------LSWIRPS DRDAFLEE----------------------------------------FRTSL------- ------------------------------------------------------------ -------PKSCD-L------------------------ >ENSPPAP00000030649 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------M-----------SRQT------------------------ ----------------------TSVGS-------------------------S------- ------CLDLWREKNDRLVRQAK-VA-QN------------------------------- ------------------------------------------SGLT-------------- ------------------------LRRQ-------------------------------- --------QLAQD---------------------------------------------AL EGLRGLLHSL-------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------Q----------------------------------G--- -------------------------------------------LPAAVPVLP-------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------LELTVTCNFIILRAS- -LAQGFTEDQAQDIQRSLER----------------------------------VLETQE -QRG---PRLEQGLREL---------------WDSV------------------------ ------------------------------------------------------------ ---------LRASCLLPELLSALHRLVG-------------------------------- ------------------------------------------------------------ ---------------------------LQA------------------------------ ---------------------------ALWLSADRLGDLALL------------------ ---------------------------------------------------------LET LNG----------------------SQ--------S---GAS------------------ --KDLLL-----LLKTWSPPAEE------------------------------------- -----------------------------------------------------LDAPLTL QDAQGLKDVLL-------------------------------------------T----- ---------------AFAYRQGL--------QELITGNP----------------DKALS SLHEVASGLCPRPV------------------------------LVQVYTALGSCHRKMG ------------------------------------------------------------ ------NPQRAL-----LYLVAALKEGSAWGPPLLE------------------------ ---------------------------------------------------------ASR LYQQLGDT----------TAELESLELLVEALNVP----CS---SKA------------- --------PQFL----------------------------------IEVEL--------- ------------------------------------------------------------ -------LLPPPDLASPLHCGT-------------------------------------- -------------------------------QSQTKHIL--------------------- --------------ASRCLQT--------------------------------------- ------------------------------------------------------------ -----GRAGD----------AAEHY----------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ LDL--------------------------------------------------------- ------------------------------------------------------------ -----LALLL-DSS---------------------------------------------- -------------------------------------------------------EPR-- ------------------------------------------------------------ ---------------------------------------------F------S------- -----PPPSPP-GPCMPEVFLEAAVALIQAGRAQDA------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ LTLCE------------------------------------------------------- ---------------------------------------------------------ELL SRTSSL-----LPKMSRLW---------------------------EDARK--------- ------------------------------------------------------------ ---------------------------------------------------------GT- ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------K------------------- ------------------------------------------------------------ -----------ELPY--------------CPLWVSA------------------------ ------------------------------------------------------------ ------------------------------------------------------THLLQG QAWVQL--GAQKVAISEFSRCLELLFQA-------------------------------- --------TPE-EK---------------EQ----------------------------- -----------------GA--------AF----------NCEQGCK-------------- ----------------------SDA------------------A---------------- -----------------------LQQL--------------------------------- --------------------------------------------RAAALISRGLEWVAS- ---------------------------------------------------------GQD TKALQDFLLSV------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------QMCP------------------------ ----------------------------------------GNRDTYFH------------ ---------------------------------------LLQTLKRL------------- ----------------------------------------------------DRRDEATA L---------------------W------------------------WRLEAQT-----K G-S----HEDAL----------W-------------S----------------------- ------------------LPLYLESY---------------------------------- -----------------------------------------------------LSWIRPS DRDAFLEE----------------------------------------FRTSL------- ------------------------------------------------------------ -------PKSCD-L------------------------ >ENSGGOP00000003149 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------M-----------SRQT------------------------ ----------------------TSVGS-------------------------S------- ------CLDLWREKNDRLVRQAK-VA-QN------------------------------- ------------------------------------------SGLT-------------- ------------------------LRRQ-------------------------------- --------QLAQD---------------------------------------------AL EGLRGLLHSL-------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------Q----------------------------------G--- -------------------------------------------LPAAVPVLP-------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------LELTVTCNFIILRAS- -LAQGFTEDQAQDIQRSLER----------------------------------VLETQE -QRG---PRLEQGLREL---------------WDSV------------------------ ------------------------------------------------------------ ---------LRASCLLPELLSALHRLVG-------------------------------- ------------------------------------------------------------ ---------------------------LQA------------------------------ ---------------------------ALWLSADRLGDLALL------------------ ---------------------------------------------------------LET LNG----------------------SQ--------S---GAS------------------ --KDLLL-----LLKTWSPPAEE------------------------------------- -----------------------------------------------------LDAPLTL QDAQGLKDVLL-------------------------------------------T----- ---------------AFAYRQGL--------QELITGNP----------------DKALS SLHEVASGLCPRPV------------------------------LVQVYTALGSCHRKMG ------------------------------------------------------------ ------NPQRAL-----LYLVAALKEGSAWGPPLLE------------------------ ---------------------------------------------------------ASR LYQQLGDT----------TAELESLELLVEALNVP----CS---SKA------------- --------PQFL----------------------------------IEVEL--------- ------------------------------------------------------------ -------LLPPPDLASPLHCGT-------------------------------------- -------------------------------QSQTKHIL--------------------- --------------ASRCLQT--------------------------------------- ------------------------------------------------------------ -----GRAGD----------AAEHY----------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ LDL--------------------------------------------------------- ------------------------------------------------------------ -----LALLL-DSS---------------------------------------------- -------------------------------------------------------EPR-- ------------------------------------------------------------ ---------------------------------------------F------S------- -----PPPSPP-GPCMPEVFLEAAVALIQAGRAQDA------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ LTLCE------------------------------------------------------- ---------------------------------------------------------ELL SRTSSL-----LPKMSRLW---------------------------EDARK--------- ------------------------------------------------------------ ---------------------------------------------------------GT- ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------K------------------- ------------------------------------------------------------ -----------ELPY--------------CPLWVSA------------------------ ------------------------------------------------------------ ------------------------------------------------------THLLQG QAWVQL--GAQKVAISEFSRCLELLFRA-------------------------------- --------TPE-EK---------------EQ----------------------------- -----------------GA--------AF----------NCEQGCK-------------- ----------------------SDA------------------A---------------- -----------------------LQQL--------------------------------- --------------------------------------------RAAALISRGLEWVAS- ---------------------------------------------------------GQD TRALQDFLLSV------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------QMCP------------------------ ----------------------------------------GNRDTYFH------------ ---------------------------------------LLQTLKRL------------- ----------------------------------------------------DRRDEATA L---------------------W------------------------WRLEAQT-----K G-S----HEDAL----------W-------------S----------------------- ------------------LPLYLESY---------------------------------- -----------------------------------------------------LSWIRPS DRDAFLEE----------------------------------------FRTSL------- ------------------------------------------------------------ -------PKSCD-L------------------------ >ENSP00000367910 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------M-----------SRQT------------------------ ----------------------TSVGS-------------------------S------- ------CLDLWREKNDRLVRQAK-VA-QN------------------------------- ------------------------------------------SGLT-------------- ------------------------LRRQ-------------------------------- --------QLAQD---------------------------------------------AL EGLRGLLHSL-------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------Q----------------------------------G--- -------------------------------------------LPAAVPVLP-------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------LELTVTCNFIILRAS- -LAQGFTEDQAQDIQRSLER----------------------------------VLETQE -QQG---PRLEQGLREL---------------WDSV------------------------ ------------------------------------------------------------ ---------LRASCLLPELLSALHRLVG-------------------------------- ------------------------------------------------------------ ---------------------------LQA------------------------------ ---------------------------ALWLSADRLGDLALL------------------ ---------------------------------------------------------LET LNG----------------------SQ--------S---GAS------------------ --KDLLL-----LLKTWSPPAEE------------------------------------- -----------------------------------------------------LDAPLTL QDAQGLKDVLL-------------------------------------------T----- ---------------AFAYRQGL--------QELITGNP----------------DKALS SLHEAASGLCPRPV------------------------------LVQVYTALGSCHRKMG ------------------------------------------------------------ ------NPQRAL-----LYLVAALKEGSAWGPPLLE------------------------ ---------------------------------------------------------ASR LYQQLGDT----------TAELESLELLVEALNVP----CS---SKA------------- --------PQFL----------------------------------IEVEL--------- ------------------------------------------------------------ -------LLPPPDLASPLHCGT-------------------------------------- -------------------------------QSQTKHIL--------------------- --------------ASRCLQT--------------------------------------- ------------------------------------------------------------ -----GRAGD----------AAEHY----------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ LDL--------------------------------------------------------- ------------------------------------------------------------ -----LALLL-DSS---------------------------------------------- -------------------------------------------------------EPR-- ------------------------------------------------------------ ---------------------------------------------F------S------- -----PPPSPP-GPCMPEVFLEAAVALIQAGRAQDA------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ LTLCE------------------------------------------------------- ---------------------------------------------------------ELL SRTSSL-----LPKMSRLW---------------------------EDARK--------- ------------------------------------------------------------ ---------------------------------------------------------GT- ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------K------------------- ------------------------------------------------------------ -----------ELPY--------------CPLWVSA------------------------ ------------------------------------------------------------ ------------------------------------------------------THLLQG QAWVQL--GAQKVAISEFSRCLELLFRA-------------------------------- --------TPE-EK---------------EQ----------------------------- -----------------GA--------AF----------NCEQGCK-------------- ----------------------SDA------------------A---------------- -----------------------LQQL--------------------------------- --------------------------------------------RAAALISRGLEWVAS- ---------------------------------------------------------GQD TKALQDFLLSV------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------QMCP------------------------ ----------------------------------------GNRDTYFH------------ ---------------------------------------LLQTLKRL------------- ----------------------------------------------------DRRDEATA L---------------------W------------------------WRLEAQT-----K G-S----HEDAL----------W-------------S----------------------- ------------------LPLYLESY---------------------------------- -----------------------------------------------------LSWIRPS DRDAFLEE----------------------------------------FRTSL------- ------------------------------------------------------------ -------PKSCD-L------------------------ >ENSPPYP00000021407 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------M-----------SRQT------------------------ ----------------------TSVGS-------------------------S------- ------CLDLWREKNDRLVRQAE-VA-QN------------------------------- ------------------------------------------SGLT-------------- ------------------------LRRQ-------------------------------- --------HLAQD---------------------------------------------AL EGLRGLLHSL-------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------Q----------------------------------G--- -------------------------------------------LPAAIPVLP-------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------LELTVTCNFIILRAS- -LAQGFTEDQAQDIQRSLER----------------------------------VLETQE -QWG---PRLEQGLREL---------------WDSV------------------------ ------------------------------------------------------------ ---------LRASCLLPELLSALHRLAG-------------------------------- ------------------------------------------------------------ ---------------------------LQA------------------------------ ---------------------------ALWLSADRLGDLALL------------------ ---------------------------------------------------------LET LNG----------------------SQ--------S---GAS------------------ --KDLLL-----LLKTWSPPAEE------------------------------------- -----------------------------------------------------LDAPLTL QDAQGLKDVLL-------------------------------------------T----- ---------------AFAYRQGL--------QELITGNP----------------DKALS SLHEAASGLCPRPV------------------------------LVQVYTALGSCHRKMG ------------------------------------------------------------ ------NPQRAL-----LYLVAALKEGSAWGPPLLE------------------------ ---------------------------------------------------------ASR LYQQLGDT----------TAELESLELLVEALNVP----CS---SKA------------- --------PQFL----------------------------------IEVEL--------- ------------------------------------------------------------ -------LLPPPDLASPLHCGT-------------------------------------- -------------------------------QSQTKHIL--------------------- --------------ASRCLQT--------------------------------------- ------------------------------------------------------------ -----GRAGD----------AAEHY----------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ LDL--------------------------------------------------------- ------------------------------------------------------------ -----LALLL-DSS---------------------------------------------- -------------------------------------------------------EPR-- ------------------------------------------------------------ ---------------------------------------------F------S------- -----PPPSPP-GPCMPEVFLEAAVALIQAGRAQDA------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ LTLCE------------------------------------------------------- ---------------------------------------------------------ELL SRTSSL-----LPKMSRLW---------------------------EDARK--------- ------------------------------------------------------------ ---------------------------------------------------------GT- ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------K------------------- ------------------------------------------------------------ -----------ELPY--------------CPLWVSA------------------------ ------------------------------------------------------------ ------------------------------------------------------THLLQG QAWVQL--GAQKVAISEFSRCLELLFRA-------------------------------- --------TPE-EK---------------EK----------------------------- -----------------GA--------AF----------NCEQGCK-------------- ----------------------SDV------------------A---------------- -----------------------LQQL--------------------------------- --------------------------------------------RAAALISRGLEWVAS- ---------------------------------------------------------GQD TKALQDFLLSV------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------QMCP------------------------ ----------------------------------------GNRDTYFH------------ ---------------------------------------LLQTLKRL------------- ----------------------------------------------------DRRDEASA L---------------------W------------------------WRLEAQT-----K G-P----HEDAM----------W-------------S----------------------- ------------------LPLYLESY---------------------------------- -----------------------------------------------------LSWIRPS DRDALLEE----------------------------------------FRTSL------- ------------------------------------------------------------ -------PKSCD-L------------------------ >ENSPCOP00000021133 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------M-----------SLQT------------------------ ----------------------PP-DS-------------------------S------- ------CLDLWREKNDQLVRQAK-VA-QD------------------------------- ------------------------------------------SDLS-------------- ------------------------LRRQ-------------------------------- --------QLAQD---------------------------------------------AL EGLRELLHSL-------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------Q----------------------------------G--- -------------------------------------------LPAAVPVLP-------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------LELTVTCNFIILKTS- -VTQGFTEDQALDIQWGLER----------------------------------VLETQE -QLG---PRLERGLRDL---------------WDSV------------------------ ------------------------------------------------------------ ---------LYASSLLPELLPALHRLAG-------------------------------- ------------------------------------------------------------ ---------------------------LQA------------------------------ ---------------------------ALWLSTDHLRDLALL------------------ ---------------------------------------------------------LQT LNG----------------------SQ--------S---GSS------------------ --EDLLL-----HLKTWSPPAEE------------------------------------- -----------------------------------------------------SDAPLTL QDARGLRDVLL-------------------------------------------T----- ---------------AFTYRQGL--------QELIIGNL----------------PKALS SLHEAASGLCPRPV------------------------------LVQVYTALGTCLRKMG ------------------------------------------------------------ ------NPQRAL-----VYLIEALKGGSTLGPPLLE------------------------ ---------------------------------------------------------ASR LYQQLGDT----------AAELESLELLVEALSVT----HS---SEA------------- --------PQLL----------------------------------IEVEL--------- ------------------------------------------------------------ -------LLPRPDPASPLHCGT-------------------------------------- -------------------------------QSQAKHLL--------------------- --------------ASRCLQT--------------------------------------- ------------------------------------------------------------ -----GRAED----------AAEHY----------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ LDL--------------------------------------------------------- ------------------------------------------------------------ -----LALLL-DGS---------------------------------------------- -------------------------------------------------------EPR-- ------------------------------------------------------------ ---------------------------------------------F------S------- -----PPHSLP-GPCMPEVFLEAAAALIQAGRAQDA------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ LTVCE------------------------------------------------------- ---------------------------------------------------------ELL SRASSL-----LPKMSQLW---------------------------KDDRK--------- ------------------------------------------------------------ ---------------------------------------------------------GT- ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------K------------------- ------------------------------------------------------------ -----------DLPH--------------CPLWVSA------------------------ ------------------------------------------------------------ ------------------------------------------------------THLLQG QAWVQL--GAQKEAVSEFSWCLELLFRA-------------------------------- --------TPE-DK---------------EQ----------------------------- -----------------GA--------AS----------NCEQGCK-------------- ----------------------SDV------------------A---------------- -----------------------LQQL--------------------------------- --------------------------------------------RAAALISRGLEWVAR- ---------------------------------------------------------GQD TKALQDFLLSV------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------QMCP------------------------ ----------------------------------------GNQDASIH------------ ---------------------------------------LLQTLRRL------------- ----------------------------------------------------DRRDEATA L---------------------W------------------------WRLEAQT-----K L-P----QKDTT----------W-------------S----------------------- ------------------LPLYLETC---------------------------------- -----------------------------------------------------LSWIRPS DHETLLEE----------------------------------------FRISV------- ------------------------------------------------------------ -------LEPRD-L------------------------ >ENSPSMP00000007231 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------M-----------SHQT------------------------ ----------------------PP-DS-------------------------S------- ------CLDLWREKNDQLVRQVK-VA-QD------------------------------- ------------------------------------------SGLS-------------- ------------------------LRRQ-------------------------------- --------QLAQD---------------------------------------------AL EGLRELLCSL-------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------Q----------------------------------G--- -------------------------------------------LPAAVAVLP-------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------LELTVTCNFIILKTS- -VAQGFTEDQTQDIQRGLER----------------------------------VLETQE -QLG---PRLERGLMEL---------------WDSV------------------------ ------------------------------------------------------------ ---------LHASSLLLDLLPALHRLAG-------------------------------- ------------------------------------------------------------ ---------------------------LQA------------------------------ ---------------------------ALWLSTDHLRDLALL------------------ ---------------------------------------------------------LQT LNG----------------------SQ--------S---GSS------------------ --EDLLL-----HLKTWSPPAEE------------------------------------- -----------------------------------------------------SDAPLTL QDARGLRDVLL-------------------------------------------T----- ---------------AFTYRQGL--------QELIIGNL----------------PKALS SLHEAASGLCPRPV------------------------------LVQVYTALGTCLRKMG ------------------------------------------------------------ ------NPQRAL-----VYLVEALKGGSALGPPLLE------------------------ ---------------------------------------------------------ASR LYQQLGDT----------AAELESLELLVEALSVT----HS---SEA------------- --------PQLL----------------------------------IEVEL--------- ------------------------------------------------------------ -------LLPRLDPALPLHCGT-------------------------------------- -------------------------------QSQAKHLL--------------------- --------------ASRCLQT--------------------------------------- ------------------------------------------------------------ -----GRAED----------AAEHY----------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ LDL--------------------------------------------------------- ------------------------------------------------------------ -----LALLL-DGS---------------------------------------------- -------------------------------------------------------EPR-- ------------------------------------------------------------ ---------------------------------------------F------A------- -----PPPSPP-GPCMPEVFLEAAAALIQAGRAQDA------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ LTVCE------------------------------------------------------- ---------------------------------------------------------ELL SRTSFL-----LPKMSQLW---------------------------KGARK--------- ------------------------------------------------------------ ---------------------------------------------------------GT- ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------K------------------- ------------------------------------------------------------ -----------GLPH--------------CPLWVSA------------------------ ------------------------------------------------------------ ------------------------------------------------------THLLQG QAWVQL--GAQKEAVSEFSWCLELLFRS-------------------------------- --------TPE-DK---------------EQ----------------------------- -----------------GA--------AS----------NCEQGCK-------------- ----------------------SEV------------------A---------------- -----------------------LQQL--------------------------------- --------------------------------------------QAAALISRGLEWVAC- ---------------------------------------------------------GQD TKALQDFLLSV------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------QMCP------------------------ ----------------------------------------GNRDASIH------------ ---------------------------------------LLQTLRRL------------- ----------------------------------------------------DRRDEATA L---------------------W------------------------WRLEAQT-----K L-P----QKDTT----------W-------------S----------------------- ------------------LPLYLETC---------------------------------- -----------------------------------------------------LSWIRPS DHETLLEE----------------------------------------FRTSV------- ------------------------------------------------------------ -------LEPRG-L------------------------ >ENSMICP00000005010 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------M-----------SHQM------------------------ ----------------------PQ-GP-------------------------N------- ------CLDLWREKNDQLVRQAK-VA-QD------------------------------- ------------------------------------------SSLS-------------- ------------------------LRRQ-------------------------------- --------QLAQD---------------------------------------------AL EGLRELLHSL-------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------Q----------------------------------G--- -------------------------------------------LPAAVPALP-------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------LELTVTCNFIILKTS- -VAQGFTEDQAQAIQRGLER----------------------------------VLETQE -QLG---PRLERGLGEL---------------WDSV------------------------ ------------------------------------------------------------ ---------LHVSSLLPELLPALHCLAG-------------------------------- ------------------------------------------------------------ ---------------------------LQA------------------------------ ---------------------------ALWLSTDHLRYLALL------------------ ---------------------------------------------------------LQS LNG----------------------SQ--------S---GSS------------------ --EDLLL-----HLKTWSPPAEE------------------------------------- -----------------------------------------------------SDAPLIL QDAQGLRDVLL-------------------------------------------TGFSGL IPSLSYPIQLHGTYL-----------------ELIIGNL----------------PKALS SLHEVASGLCPRPV------------------------------LVQVYTALGTCLRKMG ------------------------------------------------------------ ------NPQRAL-----VYLVEALKGGSALGPPLLE------------------------ ---------------------------------------------------------ASR LYQQLGDT----------AAELESLELLVEALSVT----QS---SEA------------- --------PQLL----------------------------------IEVEL--------- ------------------------------------------------------------ -------LLPQSDPASPLHCGT-------------------------------------- -------------------------------QSQAKHLL--------------------- --------------ASRCLQT--------------------------------------- ------------------------------------------------------------ -----GRAED----------AAEHY----------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ LDL--------------------------------------------------------- ------------------------------------------------------------ -----LALLL-DGS---------------------------------------------- -------------------------------------------------------EPR-- ------------------------------------------------------------ ---------------------------------------------F------S------- -----PPPSPP-GPCMPEVFLEAAAALIQAGRAQDA------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ LTVCE------------------------------------------------------- ---------------------------------------------------------ELL SRTSSL-----LPKMSQLW---------------------------KDARK--------- ------------------------------------------------------------ ---------------------------------------------------------GT- ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------K------------------- ------------------------------------------------------------ -----------DLPH--------------CPLWVSA------------------------ ------------------------------------------------------------ ------------------------------------------------------THLLQG QAWVQL--GSQKEAVSEFSWCLELLFRA-------------------------------- --------TPK-DK---------------EQ----------------------------- -----------------GA--------PS----------NCEQGCK-------------- ----------------------SDV------------------T---------------- -----------------------LQQL--------------------------------- --------------------------------------------RAAALISRGLEWVAR- ---------------------------------------------------------GQD TKALQDFLLSV------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------QMCP------------------------ ----------------------------------------GNRDASIH------------ ---------------------------------------LLQTLRRL------------- ----------------------------------------------------DRRDEATA F---------------------W------------------------WRLEAQT-----K L-P----QKDAT----------W-------------S----------------------- ------------------LPLYLETC---------------------------------- -----------------------------------------------------LSWIRPS DHETCLEE----------------------------------------FRTSV------- ------------------------------------------------------------ -------LEPRD-L------------------------ >ENSTSYP00000013694 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------M-----------SRQT------------------------ ----------------------LP-DS-------------------------G------- ------CLDLWREQNDRFVRQAK-MA-QD------------------------------- ------------------------------------------SGLS-------------- ------------------------LRRQ-------------------------------- --------QLAQD---------------------------------------------AL EGLKGLICTL-------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------Q----------------------------------G--- -------------------------------------------IPAAVPVLS-------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------LELTVICNFIILKAS- -LAQGFTEDQAQDIQRGLER----------------------------------VLETQE -QLG---PTLQWGLREL---------------WDSV------------------------ ------------------------------------------------------------ ---------LRASSCLPELLPAVHHLAS-------------------------------- ------------------------------------------------------------ ---------------------------LQA------------------------------ ---------------------------ALWLSTDHLGDLALL------------------ ---------------------------------------------------------LQA LNG----------------------SQ--------T---GAS------------------ --EDLLL-----LLKTWNPPSEE------------------------------------- -----------------------------------------------------LDAPLIL QDARGLKDVLV-------------------------------------------T----- ---------------AFAYRQGL--------QELITGNL----------------PKALR SLHEATSTLCPRSV------------------------------LVQVYTALGTCLRKMG ------------------------------------------------------------ ------NPQRAL-----LYLLAALKVGSACGPPLLE------------------------ ---------------------------------------------------------ASR LYQQLGDT----------AAELESLELLVEALGVP----LN---SKA------------- --------PQLL----------------------------------IEVEL--------- ------------------------------------------------------------ -------LLPPPDPDSPLHCGT-------------------------------------- -------------------------------QGQAKHLL--------------------- --------------ASRCLQT--------------------------------------- ------------------------------------------------------------ -----GRAED----------AAEHY----------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ LDL--------------------------------------------------------- ------------------------------------------------------------ -----LALLL-DDS---------------------------------------------- -------------------------------------------------------EPR-- ------------------------------------------------------------ ---------------------------------------------F------S------- -----PPPCPP-GPCMPELFLEAAAALIQAGRAQDA------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ LTICE------------------------------------------------------- ---------------------------------------------------------ELL GRTSSL-----LPKMSQLW---------------------------EDARK--------- ------------------------------------------------------------ ---------------------------------------------------------GT- ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------K------------------- ------------------------------------------------------------ -----------ELPQ--------------CPLWVSA------------------------ ------------------------------------------------------------ ------------------------------------------------------THLLQG QAWVQL--RAQKEAVSEFSRCLELLFRV-------------------------------- --------TLE-DK---------------EQ----------------------------- -----------------GA--------SS----------SCEHGCK-------------- ----------------------SDV------------------V---------------- -----------------------RQQL--------------------------------- --------------------------------------------RSAALISRGLEWVAS- ---------------------------------------------------------GQD TKALQDFLLSV------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------QVCP------------------------ ----------------------------------------GNQDASFH------------ ---------------------------------------LLQTLRRL------------- ----------------------------------------------------DRKDEATA L---------------------W------------------------WKMEAQT-----K L-P----QEAAT----------W-------------S----------------------- ------------------LPLYLETY---------------------------------- -----------------------------------------------------LNWIHPS ERETLLEE----------------------------------------FQTSL------- ------------------------------------------------------------ -------LEPCD-L------------------------ >ENSCCNP00000025332 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------M-----------SQQTW----------------------- ---------SA---------SLSL-DSSAP--------------------RTS------- ------CLDLWREKNDRLVRQAK-VA-QN------------------------------- ------------------------------------------TRLS-------------- ------------------------LRRQ-------------------------------- --------QLAQD---------------------------------------------TL EGLRELLHSL-------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------Q----------------------------------G--- -------------------------------------------LPAAISVLP-------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------LELTVICNFITLRVS- -LARGFTDDLTQDIQQGLER----------------------------------VLETQE -QLG---PRVGQGLGEL---------------WDAI------------------------ ------------------------------------------------------------ ---------LRASSLLPELLPALHHLVG-------------------------------- ------------------------------------------------------------ ---------------------------LQA------------------------------ ---------------------------ALWLSTDRIGDLALL------------------ ---------------------------------------------------------LQT LNG----------------------SQ--------S---GAS------------------ --EDLLL-----LLKTWSPPVKE------------------------------------- -----------------------------------------------------SDAPLTL QDAQGLRDVLL-------------------------------------------T----- ---------------AFAFRQGL--------QELITGSL----------------PRALS ILHEAASGLCPRPV------------------------------LVQVYTALGTCLRKMG ------------------------------------------------------------ ------NPQRAL-----LYLIAALKVGTACGLPLLE------------------------ ---------------------------------------------------------ASR LYQQLGDA----------SAELESLELLVEALSAT----HS---FEA------------- --------PQLL----------------------------------IEVEL--------- ------------------------------------------------------------ -------LLPQPDQASPLHCGT-------------------------------------- -------------------------------QSQAKHLL--------------------- --------------ASRCLQL--------------------------------------- ------------------------------------------------------------ -----GRAED----------AAEHY----------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ LDL--------------------------------------------------------- ------------------------------------------------------------ -----LALLL-DGS---------------------------------------------- -------------------------------------------------------EPR-- ------------------------------------------------------------ ---------------------------------------------F------S------- -----PPPAPP-GPCVPEVFLEAAAAMIQAGRAQDA------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ LTICE------------------------------------------------------- ---------------------------------------------------------ELL SRTSAL-----LPKMSQLW---------------------------EDARK--------- ------------------------------------------------------------ ---------------------------------------------------------GA- ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------K------------------- ------------------------------------------------------------ -----------ELPH--------------CPLWVSA------------------------ ------------------------------------------------------------ ------------------------------------------------------THLLQG QAWVQL--KAQKEAVSEFSWCLELLFRA-------------------------------- --------TPE-DK---------------EQ----------------------------- -----------------GA--------VP----------NCEQGCK-------------- ----------------------SDV------------------V---------------- -----------------------LQQL--------------------------------- --------------------------------------------RAAALISRGLEWVAS- ---------------------------------------------------------GQD TKALKDFLLSV------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------QMSP------------------------ ----------------------------------------GNKDASFH------------ ---------------------------------------LLQTLKKL------------- ----------------------------------------------------DRKDEALV L---------------------W------------------------QRLKVQT-----Q M-P----QEEAA----------W-------------S----------------------- ------------------LPLYLETY---------------------------------- -----------------------------------------------------LSWIHPP DCETLLEE----------------------------------------FRTAL------- ------------------------------------------------------------ -------LEPCD-L------------------------ >ENSDNOP00000011296 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------M-----------SLEA------------------------ ---------SL--------------DCSGP--------------------RAS------- ------CLDLWREKNDQLVRQSK-VA-QT------------------------------- ------------------------------------------SGVS-------------- ------------------------LRRQ-------------------------------- --------QLAQD---------------------------------------------AL EGLRGLLRSL-------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------Q----------------------------------G--- -------------------------------------------LPAAVSALP-------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------LELTVICNFITLRAS- -LAQGFTEDQAQEIQRGLER----------------------------------VLEAQA -QLG---PRPEYGLREL---------------WDFV------------------------ ------------------------------------------------------------ ---------LHSSSRMPELLPALHHLAG-------------------------------- ------------------------------------------------------------ ---------------------------LQA------------------------------ ---------------------------ALWLSTDHLGDLGLL------------------ ---------------------------------------------------------LQT LNG----------------------SQ--------S---GAS------------------ --EDLLV-----LLKTWSPPAEE------------------------------------- -----------------------------------------------------SEAPLSL QDTRGLRDVLL-------------------------------------------T----- ---------------ASAFRQGL--------QELITGNL----------------PRALS NLHEAASGLCPRPV------------------------------LVQVYTALATCLRKMG ------------------------------------------------------------ ------NPQRAL-----LYLVAALKGGSAWGPPLLE------------------------ ---------------------------------------------------------ACR LYQQLGNI----------AAELESLELLVEALSIT----QS---SEI------------- --------PQLL----------------------------------IEVKL--------- ------------------------------------------------------------ -------LLPQPDPASPLHCGT-------------------------------------- -------------------------------QSQAKHLL--------------------- --------------ASRCLQT--------------------------------------- ------------------------------------------------------------ -----GRAED----------AAEHY----------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ LDL--------------------------------------------------------- ------------------------------------------------------------ -----LALLL-DGP---------------------------------------------- -------------------------------------------------------EPR-- ------------------------------------------------------------ ---------------------------------------------F------S------- -----PPHLPP-GPSMPEVFLEAAAALIEAGRAQDA------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ LTVCE------------------------------------------------------- ---------------------------------------------------------ELL HRTSSL-----LPKMHWLW---------------------------EDARK--------- ------------------------------------------------------------ ---------------------------------------------------------EA- ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------K------------------- ------------------------------------------------------------ -----------EPPH--------------CPLWVSA------------------------ ------------------------------------------------------------ ------------------------------------------------------TYLLQG QAWVQL--GSQKEAISEFSRCLELLFRA-------------------------------- --------MPE-DK---------------EE----------------------------- -----------------GA--------AS----------SCEQGCR-------------- ----------------------PNV------------------T---------------- -----------------------LQQL--------------------------------- --------------------------------------------QAAALISRGLQWVAS- ---------------------------------------------------------GQD TKALQDFLLSV------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------QMCP------------------------ ----------------------------------------RNQDASFH------------ ---------------------------------------LLQTLRRL------------- ----------------------------------------------------DRRDEATA L---------------------W------------------------WRLEAQS-----K L-P----QEDAV----------W-------------S----------------------- ------------------LPLYLEAC---------------------------------- -----------------------------------------------------LSWTRPP DCETLLEE----------------------------------------FRTSL------- ------------------------------------------------------------ -------LEPCE-Q------------------------ >ENSLAFP00000017720 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------T-----------MSQT------------------------ ----------------------PL-DSPSP--------------------RAS------- ------CLDLWREKNDLLVRQAK-VT-QD------------------------------- ------------------------------------------SGLL-------------- ------------------------LRQQ-------------------------------- --------HLAQD---------------------------------------------AL QGFRELLHSL-------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------R----------------------------------G--- -------------------------------------------LPAAISALP-------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------LELTVICNFITLKVS- -HTQGFTEDQAQDIQQGLER----------------------------------VLEAQE -QLG---PRLECGLREL---------------WDSV------------------------ ------------------------------------------------------------ ---------LHISSLLPELLPALHHLAG-------------------------------- ------------------------------------------------------------ ---------------------------LQA------------------------------ ---------------------------ALWLSTDRLGDLALL------------------ ---------------------------------------------------------LQS LNG----------------------SQ--------S---GAS------------------ --EDLLL-----LLKTWSPPVEE------------------------------------- -----------------------------------------------------SDAPLTL QDARGLRDVLL-------------------------------------------T----- ---------------ASALCQGL--------QELITGTL----------------PRALS SLQEAASGLCSRPV------------------------------LVQVYTALGTCLRKMG ------------------------------------------------------------ ------NPQRAL-----LYLVAALKGGSVWGPPLLE------------------------ ---------------------------------------------------------ASR LYRQLGDT----------AAELESLELLVDALSVT----QN---SET------------- --------PQLL----------------------------------IEVEL--------- ------------------------------------------------------------ -------LLPQPNPDSPLYCGT-------------------------------------- -------------------------------QSQAKHLL--------------------- --------------ASRCLQT--------------------------------------- ------------------------------------------------------------ -----GRAED----------AAEHY----------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ LDL--------------------------------------------------------- ------------------------------------------------------------ -----LALLL-DGL---------------------------------------------- -------------------------------------------------------EPR-- ------------------------------------------------------------ ---------------------------------------------F------S------- -----PLPCPP-GPCMPEVFLEAAAALIQANRAQDA------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ LTVCE------------------------------------------------------- ---------------------------------------------------------ELL IRTSSL-----LPKMPWSW---------------------------EDARN--------- ------------------------------------------------------------ ---------------------------------------------------------GA- ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------K------------------- ------------------------------------------------------------ -----------EPIN--------------CPLWVSA------------------------ ------------------------------------------------------------ ------------------------------------------------------TYLLQG QAWVKM--GDQKEAVSEFSRCLELLFRA-------------------------------- --------TPE-DR---------------EQ----------------------------- -----------------GA--------AS----------NSDQRCR-------------- ----------------------PDV------------------A---------------- -----------------------LQQL--------------------------------- --------------------------------------------RLAALISRGLVWVAS- ---------------------------------------------------------GQD TKALQDFLLSV------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------QICP------------------------ ----------------------------------------GNRDASFH------------ ---------------------------------------LLQTLRRL------------- ----------------------------------------------------DRRNEATA F---------------------W------------------------WRLEAQT-----E L-P----PEDAT----------W-------------S----------------------- ------------------LPLYLETC---------------------------------- -----------------------------------------------------LSWIHPL DQETLLEE----------------------------------------FRTSL------- ------------------------------------------------------------ -------LETSD-L------------------------ >ENSSTOP00000013621 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------QSRQRV- --LLGGCLDLWKEKNDRLVRQAK-VA-QD------------------------------- ------------------------------------------SGVS-------------- ------------------------LRRH-------------------------------- --------KLVQD---------------------------------------------TL EGLRELLHIL-------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------H----------------------------------G--- -------------------------------------------LPAAVPVLP-------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------LELTVTCNFIILKVS- -LAQGFTEDQAQDIQRGLER----------------------------------VLETQE -QLG---PRPEQGIRKL---------------WESV------------------------ ------------------------------------------------------------ ---------LCASSLLPKLLCALHHLAG-------------------------------- ------------------------------------------------------------ ---------------------------LQA------------------------------ ---------------------------ALWLSIDRLEDLALL------------------ ---------------------------------------------------------LQT LNG----------------------NQ--------N---GAS------------------ --KDLLL-----LLKTWNPPAEE------------------------------------- -----------------------------------------------------SDAPLTL QNAQGLRDILL-------------------------------------------T----- ---------------AFAYRQGL--------QELISGSL----------------PRALS SLHEAASGLCPRPL------------------------------LVQVYTALGSCLRKMG ------------------------------------------------------------ ------NPQRAL-----LYLIAALKGGSPWGLPLLE------------------------ ---------------------------------------------------------ASR LYRQLGDT----------AAELESLELLVEALSTT----HS---SEV------------- --------PQPL----------------------------------IEVEL--------- ------------------------------------------------------------ -------LLPRPDPASPLYCGT-------------------------------------- -------------------------------QSQAKHLL--------------------- --------------ASRCLQM--------------------------------------- ------------------------------------------------------------ -----GRAED----------AAEHY----------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ LDL--------------------------------------------------------- ------------------------------------------------------------ -----LALLL-DGS---------------------------------------------- -------------------------------------------------------DPR-- ------------------------------------------------------------ ---------------------------------------------F------C------- -----PPTSPP-GPCMPEVFLEAAAALIQAGRAQDA------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ LTVCE------------------------------------------------------- ---------------------------------------------------------ELL TRTSSL-----LPKMLQPW---------------------------EDARK--------- ------------------------------------------------------------ ---------------------------------------------------------GT- ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------K------------------- ------------------------------------------------------------ -----------ELPS--------------CPLWVSA------------------------ ------------------------------------------------------------ ------------------------------------------------------VYLLQG RAWVQL--RAPKEAISEFSRCLELLFRA-------------------------------- --------IPE-DK---------------EQ----------------------------- -----------------GA--------AS----------NCEQGCR-------------- ----------------------SDM------------------A---------------- -----------------------LKHL--------------------------------- --------------------------------------------RAAALISRGLEWAAN- ---------------------------------------------------------GQD TKALQDFLLSV------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------QVCP------------------------ ----------------------------------------GNRDASFY------------ ---------------------------------------LLQTLRRL------------- ----------------------------------------------------DRKDEAAA F---------------------C------------------------WRLQAQT-----Q L-----------------------------------S----------------------- ------------------LPLYLEIY---------------------------------- -----------------------------------------------------LSWIHSP DCETFLEE----------------------------------------FQTSL------- ------------------------------------------------------------ -------QEPHD-L------------------------ >ENSUPAP00010023247 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------M-----------AHQS------------------------ ----------------------FL-GSPEA--------------------RAS------- ------CLDLWKEKNDRLVRQAK-VA-QD------------------------------- ------------------------------------------SGVS-------------- ------------------------LRRH-------------------------------- --------KLVQD---------------------------------------------TL EGLRELLHIL-------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------H----------------------------------G--- -------------------------------------------LPAAVPVLP-------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------LELTVTCNFIILKVS- -LAQGFTEDEAQDIQRGLER----------------------------------VLETQE -QLG---PRPEQGIRKL---------------WESV------------------------ ------------------------------------------------------------ ---------LCASSLLPKLLCALHHLVG-------------------------------- ------------------------------------------------------------ ---------------------------LQA------------------------------ ---------------------------ALWLSIDRLEDLALL------------------ ---------------------------------------------------------LQT LNG----------------------NQ--------N---GAS------------------ --KDLLL-----LLKTWNPPAEE------------------------------------- -----------------------------------------------------SDAPLTL QNARGLRDILL-------------------------------------------T----- ---------------AFAYRQGL--------QELISGSL----------------PRALS SLHEAASGLCPRPL------------------------------LVQVYTALGSCLRKMG ------------------------------------------------------------ ------NPQRAL-----LYLIAALKGGSPWGLPLLE------------------------ ---------------------------------------------------------ASR LYRQLGDT----------AAELESLELLVEALSAT----HS---SEV------------- --------PQPL----------------------------------IEVEL--------- ------------------------------------------------------------ -------LLPRPDPASPLYCGT-------------------------------------- -------------------------------QSQAKHLL--------------------- --------------ASRCLQM--------------------------------------- ------------------------------------------------------------ -----GRAED----------AAEHY----------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ LDL--------------------------------------------------------- ------------------------------------------------------------ -----LALLL-DGS---------------------------------------------- -------------------------------------------------------DPR-- ------------------------------------------------------------ ---------------------------------------------F------C------- -----PPTSPP-GPCMPEVFLEAAAALIQAGRAQDA------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ LTVCE------------------------------------------------------- ---------------------------------------------------------ELL TRTSSL-----LPKMLQPW---------------------------EDARK--------- ------------------------------------------------------------ ---------------------------------------------------------GT- ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------K------------------- ------------------------------------------------------------ -----------ELPS--------------CPLWVSA------------------------ ------------------------------------------------------------ ------------------------------------------------------VYLLQG RAWVQL--RAPKEAISEFSRCLELLFRA-------------------------------- --------IPE-DK---------------EQ----------------------------- -----------------GA--------AS----------NCEQGCR-------------- ----------------------SDM------------------A---------------- -----------------------LKQL--------------------------------- --------------------------------------------RAAALISRGLEWAAN- ---------------------------------------------------------GQD TKALQDFLLSV------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------QMCP------------------------ ----------------------------------------GNRDASFH------------ ---------------------------------------LLQTLRRL------------- ----------------------------------------------------DRKDEAAX F---------------------C------------------------WRLQAQT-----Q L-P----QKEAT----------W-------------S----------------------- ------------------LPLYLEIY---------------------------------- -----------------------------------------------------LSWIHSP DCETFLEE----------------------------------------FQTSL------- ------------------------------------------------------------ -------QEPHD-L------------------------ >ENSSDAP00000005265 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------M-----------AHQS------------------------ ----------------------FL-GFSEA--------------------GAS------- ------CLDLWKEKNDRLVRQAKQVA-QD------------------------------- ------------------------------------------SGVS-------------- ------------------------LRRH-------------------------------- --------KLVQD---------------------------------------------TL EGLRELLHIL-------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------H----------------------------------G--- -------------------------------------------LPAAVPVLP-------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------LELTVTCNFIILKVS- -LAQGFTEDQAQDIQRGLER----------------------------------VLETQE -QLG---PRPEQGIRKL---------------WESV------------------------ ------------------------------------------------------------ ---------LCASSLLPELLCALHHLAG-------------------------------- ------------------------------------------------------------ ---------------------------LQA------------------------------ ---------------------------ALWLSIDRLEDLALL------------------ ---------------------------------------------------------LQT LNG----------------------NQ--------N---GAS------------------ --KDLLL-----LLKTWNPPAEE------------------------------------- -----------------------------------------------------SDAPLTL QNARGLRDILL-------------------------------------------T----- ---------------AFAYRQGL--------QELISGSL----------------PRALS SLHEAASGLCSRPL------------------------------LVQVYTALGSCLRKMG ------------------------------------------------------------ ------NPQRAL-----LYLIAALKGGSPWGLPLLE------------------------ ---------------------------------------------------------ASR LYRQLGDT----------AAELESLELLVEALSAT----HS---SEF------------- ---------HSL----------------------------------IEVEL--------- ------------------------------------------------------------ -------LLPPPDPASPLYCGT-------------------------------------- -------------------------------QSQAKHLL--------------------- --------------ASRCLQM--------------------------------------- ------------------------------------------------------------ -----GRAED----------AAEHY----------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ LDL--------------------------------------------------------- ------------------------------------------------------------ -----LALLL-DGS---------------------------------------------- -------------------------------------------------------DPR-- ------------------------------------------------------------ ---------------------------------------------F------C------- -----PPTSPP-GPCMPEVFLEAAAALIQAGRAQDA------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ LTVCE------------------------------------------------------- ---------------------------------------------------------ELL TRTSSL-----LPKMLQPW---------------------------EDARK--------- ------------------------------------------------------------ ---------------------------------------------------------GT- ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------K------------------- ------------------------------------------------------------ -----------ELPS--------------CPLWVSA------------------------ ------------------------------------------------------------ ------------------------------------------------------VYLLQG RAWVQL--RAPKEAISEFSRCLELLFRA-------------------------------- --------IPE-DK---------------EQ----------------------------- ---------------------------AS----------NCEQGCR-------------- ----------------------SDM------------------A---------------- -----------------------LKQL--------------------------------- --------------------------------------------RAAALISRGLEWAAN- ---------------------------------------------------------GQD TKALQDFLLSV------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------QMCP------------------------ ----------------------------------------GNRDASFH------------ ---------------------------------------LLQTLRRL------------- ----------------------------------------------------DRKNEAAA F---------------------C------------------------WRLQAQT-----Q L-P----QKEAT----------W-------------S----------------------- ------------------LPLYLEIY---------------------------------- -----------------------------------------------------LSWIHSP DCETFLEE----------------------------------------FQTSL------- ------------------------------------------------------------ -------QEPRD-L------------------------ >ENSCLAP00000002590 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------M-----------SRPS------------------------ ----------------------LL-DASAA--------------------RAS------- ------CLDLWREENDRLVRRAK------------------------------------- ------------------------------------------------------------ ------------------------LRRQ-------------------------------- --------LLTQD---------------------------------------------VL EGLRGLLRSL-------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------Q----------------------------------G--- -------------------------------------------LPAAVPALP-------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------LELAVTCNVIILRVS- -LSRVFPEDQAQGIRQALER----------------------------------VLETQE -QLG---PRLEQGLREL---------------WDSV------------------------ ------------------------------------------------------------ ---------LRASALLPALLPALHLLAG-------------------------------- ------------------------------------------------------------ ---------------------------LQA------------------------------ ---------------------------ALWLSTDRLGDLASM------------------ ---------------------------------------------------------LQT LNG----------------------SQ--------S---RAS------------------ --EDLLL-----LLKAWSPPAVE------------------------------------- -----------------------------------------------------SDAPLIL QDAQGLKDVLL-------------------------------------------T----- ---------------ASAFRQGL--------QELITGRL----------------PEALS NLQEAASSLCSRSV------------------------------LAQVYTALGNCLRKMG ------------------------------------------------------------ ------NPQRAL-----LYLIAALKEGSPLGPPLLE------------------------ ---------------------------------------------------------ASR LYQQLGDT----------TAELESLELLAEALSVT----HS---SEA------------- --------PQIL----------------------------------IEVEL--------- ------------------------------------------------------------ -------LLPRPDPASPLHCGT-------------------------------------- -------------------------------QSHVKHLL--------------------- --------------ASRCLQT--------------------------------------- ------------------------------------------------------------ -----GRAED----------AAEHY----------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ LDL--------------------------------------------------------- ------------------------------------------------------------ -----LALLF-DGS---------------------------------------------- -------------------------------------------------------EPR-- ------------------------------------------------------------ ---------------------------------------------L------S------- -----PPLCPP-GPCMPELFLEAAVALITASRAQDA------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ LTVCE------------------------------------------------------- ---------------------------------------------------------ELL SRTSFL-----LPKMHRLW---------------------------EDVRK--------- ------------------------------------------------------------ ---------------------------------------------------------GT- ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------R------------------- ------------------------------------------------------------ -----------ELPH--------------CPLWVSA------------------------ ------------------------------------------------------------ ------------------------------------------------------AHLLQG QAWVQL--RAQKEAISEFSRCLELLFRA-------------------------------- --------MPE-DK---------------DQ----------------------------- ---------------------------AS----------NCEQGCR-------------- ----------------------LDA------------------A---------------- -----------------------LQHL--------------------------------- --------------------------------------------RSAALISRGLEWAAS- ---------------------------------------------------------GQD SKALQDFFLSV------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------QMCP------------------------ ----------------------------------------GHRDASFH------------ ---------------------------------------LLQTLKKL------------- ----------------------------------------------------NRKDEASA V---------------------W------------------------RRLKAQT-----Q P-P----QEGAT----------W-------------S----------------------- ------------------LPLYLETY---------------------------------- -----------------------------------------------------LSWIHPP NCETLLEE----------------------------------------FQTSL------- ------------------------------------------------------------ -------AEPCDVL------------------------ >ENSODEP00000023024 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------M-----------SLPT------------------------ ----------------------FP-GASAP--------------------RAS------- ------CLDLWRERNDRLVRRAR------------------------------------- ---------------------------------------------EVMA----------- --------------------QECGLRRQ-------------------------------- --------QLIQD---------------------------------------------IL EGFRGVLYSL-------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------Q----------------------------------G--- -------------------------------------------LPAAVPLLP-------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------LELTVTCNFIILRVS- -LTQGFNEDQAQCVQQALKR----------------------------------VLETQE -QLG---PRLDQGLREL---------------WYSV------------------------ ------------------------------------------------------------ ---------LHVSSLLPDLLPALHLLAG-------------------------------- ------------------------------------------------------------ ---------------------------LQA------------------------------ ---------------------------AHWLSTDHLGDTAWL------------------ ---------------------------------------------------------LQT LNG----------------------TQ--------S---RAS------------------ --EDLLL-----FLKTWSPPALE------------------------------------- -----------------------------------------------------SDASLIL QDAQGLRNVLL-------------------------------------------T----- ---------------ASALRQGL--------QELITGRL----------------PKALS SLQEAASSLCSRPV------------------------------LVQVYTALGNCLRRMG ------------------------------------------------------------ ------NPQRAL-----LYLIAALKEGSACGLPLLE------------------------ ---------------------------------------------------------ASR LYRQVGDT----------TAELESLELLAEALSVT----YN---SEA------------- --------PQIL----------------------------------IEVEL--------- ------------------------------------------------------------ -------LLPRPDPASPLHCGT-------------------------------------- -------------------------------QSQVKHLL--------------------- --------------ASRCLQT--------------------------------------- ------------------------------------------------------------ -----GRAEA----------AAEHY----------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ LDL--------------------------------------------------------- ------------------------------------------------------------ -----LALLL-DGS---------------------------------------------- -------------------------------------------------------GSR-- ------------------------------------------------------------ ---------------------------------------------F------S------- -----PPSCPP-GPCMPEVFLEAALALIEAGRAQDA------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ LTVCE------------------------------------------------------- ---------------------------------------------------------ELL SRTSFL-----LPKMPRMR---------------------------EDVRK--------- ------------------------------------------------------------ ---------------------------------------------------------GT- ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------K------------------- ------------------------------------------------------------ -----------ELSH--------------CPLWVSA------------------------ ------------------------------------------------------------ ------------------------------------------------------AHLLQG QAWVQL--RVQKKAISEFTSCLELLFRT-------------------------------- --------MPE-DK---------------DQ----------------------------- ---------------------------AS----------NCEQGCR-------------- ----------------------SGA------------------T---------------- -----------------------LQHL--------------------------------- --------------------------------------------RAAALISRGLEWLAN- ---------------------------------------------------------GQD TKALQDFLLSV------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------QMCP------------------------ ----------------------------------------GHRDASFH------------ ---------------------------------------LLQTLKKL------------- ----------------------------------------------------NRRDEASA I---------------------W------------------------WRLKAQI-----Q L-P----QEEAT----------W-------------S----------------------- ------------------LPLYLETY---------------------------------- -----------------------------------------------------LSWIHPP DCETLLEE----------------------------------------FQTSI------- ------------------------------------------------------------ -------TEPCD-L------------------------ >ENSCPOP00000010804 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------M-----------SRQT------------------------ ----------------------LP-GASAP--------------------RAS------- ------CLDLWREKNDRLVRQAK------------------------------------- ---------------------------------------------GVMA----------- --------------------QECGVRRQ-------------------------------- --------QLIQN---------------------------------------------IL QGLKEVLLSL-------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------Q----------------------------------G--- -------------------------------------------LPAAVPVLP-------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------LELTITCNFIILRVS- -LTRGFTEDQAQDIQQALKR----------------------------------VLETQE -RLG---PGLELGLREL---------------WDTV------------------------ ------------------------------------------------------------ ---------LHASCLLPDLLPVLHLLAG-------------------------------- ------------------------------------------------------------ ---------------------------LQA------------------------------ ---------------------------AFWLSTEHLGDLVSL------------------ ---------------------------------------------------------LQT LNG----------------------TQ--------S---RAS------------------ --EDLLL-----LLKTWSPPAAE------------------------------------- -----------------------------------------------------SSALLIL QDARSLRDILL-------------------------------------------T----- ---------------ASAFRQGL--------QELITGSL----------------PKALS SLQEAASSMCSRSV------------------------------LVQVYTALGNCLRKMG ------------------------------------------------------------ ------KPQRAL-----LYLIAALKEGSVWGPLLLE------------------------ ---------------------------------------------------------ASR LYRQQGDT----------TAELESLELLTEALSVTQ--AHS---SKA------------- --------PQVF----------------------------------IEVEL--------- ------------------------------------------------------------ -------LLTQPDPASPLHCGT-------------------------------------- -------------------------------QSQIKHLL--------------------- --------------ASRCLQM--------------------------------------- ------------------------------------------------------------ -----GRAED----------AAEHY----------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ LDL--------------------------------------------------------- ------------------------------------------------------------ -----LALLL-DGS---------------------------------------------- -------------------------------------------------------EPR-- ------------------------------------------------------------ ---------------------------------------------F------S------- -----PPSCPP-GPCMPEVFLEAALALIQASRAQDA------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ LTVCE------------------------------------------------------- ---------------------------------------------------------ELL SRTSFL-----LPKMPRLW---------------------------EDVRR--------- ------------------------------------------------------------ ---------------------------------------------------------GT- ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------K------------------- ------------------------------------------------------------ -----------EMPH--------------CPLWVSA------------------------ ------------------------------------------------------------ ------------------------------------------------------AHLLQG QAWVQL--RTQKEAVSEFSRCLELLFRV-------------------------------- --------MPE-DK---------------GQ----------------------------- -----------------GA--------AS----------NCEQGCR-------------- ----------------------SDM------------------T---------------- -----------------------LQHL--------------------------------- --------------------------------------------RAAALISRGLEWIAS- ---------------------------------------------------------GQD TKALQDFLLSV------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------QICP------------------------ ----------------------------------------GHRDASFH------------ ---------------------------------------LLQTLKKL------------- ----------------------------------------------------NRKDEASA V---------------------W------------------------WKLKAPT-----Q L-P----QEEAT----------R-------------S----------------------- ------------------LPLYLEAY---------------------------------- -----------------------------------------------------FNWIHPP DCETLLEE----------------------------------------FQTSL------- ------------------------------------------------------------ -------AEPC--------------------------- >ENSHGLP00100000698 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------M-----------SRRT------------------------ ----------------------LL------------------------------------ ------CLDLWREKNDRLVRRAK-VTPQK------------------------------- ------------------------------------------AGLH-------------- ------------------------LRRQ-------------------------------- --------QLTQD---------------------------------------------IL EGLSGLLHSL-------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------Q----------------------------------G--- -------------------------------------------LPAAVSVLP-------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------LELTVTCNFIILRAS- -LTQGFTEDQAQDIQQALER----------------------------------VLETQE -PLV---PRLEQGLREL---------------WDSV------------------------ ------------------------------------------------------------ ---------LHASSLLPELLPALHLLAG-------------------------------- ------------------------------------------------------------ ---------------------------LQA------------------------------ ---------------------------ALWLSTDHLGDLALL------------------ ---------------------------------------------------------LQA LNG----------------------SQ--------N---RAS------------------ --EDLLL-----LLKTWSPPAEE------------------------------------- -----------------------------------------------------SDAPLIL QDAWGLRDVLL-------------------------------------------T----- ---------------ASAFHQGL--------QELITGSL----------------PKALS SLHEAASGLCSRPV------------------------------LVQVYTALGNCLRKMG ------------------------------------------------------------ ------TPQRAL-----LYLIAALKEGSALGLPLLE------------------------ ---------------------------------------------------------ASR LYRQLGNT----------TAELESLELLFEALSVT----HK---SEA------------- --------PHIL----------------------------------IEVEL--------- ------------------------------------------------------------ -------LLPQPGPASPLHCGT-------------------------------------- -------------------------------QSQVKHLL--------------------- --------------ASRCLQM--------------------------------------- ------------------------------------------------------------ -----GRAEE----------AAEHY----------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ LDL--------------------------------------------------------- ------------------------------------------------------------ -----LALLL-DVS---------------------------------------------- -------------------------------------------------------EPR-- ------------------------------------------------------------ ---------------------------------------------F------S------- -----PPPCPP-GPCMPEVFLEAAVALIKAGRAQDA------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ LTVCE------------------------------------------------------- ---------------------------------------------------------ELL SRTSSL-----LPKMSWLW---------------------------EDVRK--------- ------------------------------------------------------------ ---------------------------------------------------------GT- ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------K------------------- ------------------------------------------------------------ -----------ELPH--------------CPLWVSA------------------------ ------------------------------------------------------------ ------------------------------------------------------AHLLQG QAWVQL--RAQKEAVGEFSHCLELLFRA-------------------------------- --------VPE-DK---------------DQ----------------------------- -----------------GG--------AS----------NCEQGCS-------------- ----------------------SDV------------------A---------------- -----------------------LQHL--------------------------------- --------------------------------------------RAAALISRGLEWVAS- ---------------------------------------------------------GQD TKALQDFLLSV------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------QVCP------------------------ ----------------------------------------GHRDASFH------------ ---------------------------------------LLQTLRNL------------- ----------------------------------------------------NRRDEANA V---------------------W------------------------WKLKTQT-----Q V-P----QEEAT----------W-------------S----------------------- ------------------LPLYLETY---------------------------------- -----------------------------------------------------LSWIHPP DCETLLEE----------------------------------------FQTSL------- ------------------------------------------------------------ -------TESC--------------------------- >ENSHGLP00000015427 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------M-----------SRRT------------------------ ----------------------LL------------------------------------ ------CLDLWREKNDRLVRRAK-VTPQK------------------------------- ------------------------------------------AGLH-------------- ------------------------LRRQ-------------------------------- --------QLTQD---------------------------------------------IL EGLSGLLHSL-------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------Q----------------------------------G--- -------------------------------------------LPAAVSVLP-------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------LELTVTCNFIILRAS- -LTQGFTEDQAQDIQQALER----------------------------------VLETQE -PLV---PRLEQGLREL---------------WDSV------------------------ ------------------------------------------------------------ ---------LHASSLLPELLPALHLLAG-------------------------------- ------------------------------------------------------------ ---------------------------LQA------------------------------ ---------------------------ALWLSTDHLGDLALL------------------ ---------------------------------------------------------LQA LNG----------------------SQ--------N---RAS------------------ --EDLLL-----LLKTWSPPAEE------------------------------------- -----------------------------------------------------SDAPLIL QDAWGLRDVLL-------------------------------------------T----- ---------------ASAFHQGL--------QELITGSL----------------PKALS SLHEAASGLCSRPV------------------------------LVQVYTALGNCLRKMG ------------------------------------------------------------ ------NPQRAL-----LYLIAALKEGSALGLPLLE------------------------ ---------------------------------------------------------ASR LYRQLGNT----------TAELESLELLFEALSVT----HK---SEA------------- --------PHIL----------------------------------IEVEL--------- ------------------------------------------------------------ -------LLPQPGPASPLHCGT-------------------------------------- -------------------------------QSQVKHLL--------------------- --------------ASRCLQM--------------------------------------- ------------------------------------------------------------ -----GRAEE----------AAEHY----------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ LDL--------------------------------------------------------- ------------------------------------------------------------ -----LALLL-DVS---------------------------------------------- -------------------------------------------------------EPR-- ------------------------------------------------------------ ---------------------------------------------F------S------- -----PPPCPP-GPCMPEVFLEAAVALIKAGRAQDA------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ LTVCE------------------------------------------------------- ---------------------------------------------------------ELL SRTSSL-----LPKMSWLW---------------------------EDVRK--------- ------------------------------------------------------------ ---------------------------------------------------------GT- ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------K------------------- ------------------------------------------------------------ -----------ELPH--------------CPLWVSA------------------------ ------------------------------------------------------------ ------------------------------------------------------AHLLQG QAWVQL--RAQKEAVGEFSHCLELLFRA-------------------------------- --------VPE-DK---------------DQ----------------------------- -----------------GG--------AS----------NCEQGCS-------------- ----------------------SDV------------------A---------------- -----------------------LQHL--------------------------------- --------------------------------------------RAAALISRGLEWVAS- ---------------------------------------------------------GQD TKALQDFLLSV------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------QVCP------------------------ ----------------------------------------GHRDASFH------------ ---------------------------------------LLQTLRNL------------- ----------------------------------------------------NRRDEANA V---------------------W------------------------WKLKTQT-----Q V-P----QEEAT----------W-------------S----------------------- ------------------LPLYLETY---------------------------------- -----------------------------------------------------LSWIHPP DCETLLEE----------------------------------------FQTSL------- ------------------------------------------------------------ -------TESC--------------------------- >ENSOCUP00000005572 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------M-----------SSHT------------------------ ----------------------DP-GSSEP--------------------RAS------- ------CLDLWKDKNNRLVRQVQ-VA-QG------------------------------- ------------------------------------------SGLS-------------- ------------------------LRRQ-------------------------------- --------RLAQD---------------------------------------------TL EGLRELLHSL-------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------Q----------------------------------G--- -------------------------------------------LPAAVRVLQ-------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------LELTVTCNFIILRVG- -LAQGFTEDQAQDIQRGLER----------------------------------VLEIQE -QPG---PRAEREPMEL---------------WNSV------------------------ ------------------------------------------------------------ ---------FRASCLVPELLPALHQLVG-------------------------------- ------------------------------------------------------------ ---------------------------LQA------------------------------ ---------------------------ALWLSADRLQDLALL------------------ ---------------------------------------------------------LKA LNG----------------------SQ--------S---GTS------------------ --EDLLL-----LLKTWRPPAEE------------------------------------- -----------------------------------------------------SDAPLTL QTARGLRDVVL-------------------------------------------T----- ---------------AFAYRQGL--------RELNTGNL----------------PEALG SLHEAASGLCSRPL------------------------------LVQVYTAVGTCFRKMG ------------------------------------------------------------ ------HPQRAL-----LYLTAALKEGSALGPPLLE------------------------ ---------------------------------------------------------ASR LYRQLGDT----------AAELESLELLVEALSIA----HS---SEA------------- --------PQLL----------------------------------IDVEL--------- ------------------------------------------------------------ -------LLPLPDAASPLHCGT-------------------------------------- -------------------------------QSQAKHLL--------------------- --------------ASRCLQT--------------------------------------- ------------------------------------------------------------ -----ERAED----------AAEHY----------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ LDL--------------------------------------------------------- ------------------------------------------------------------ -----LALLL-DCS---------------------------------------------- -------------------------------------------------------ESR-- ------------------------------------------------------------ ---------------------------------------------F------S------- -----PPPCPP-GPCVPELFLEAAAALIQAGRAQDA------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ LTVCE------------------------------------------------------- ---------------------------------------------------------ELL RRTSSL-----LPKTSLLS---------------------------ENARK--------- ------------------------------------------------------------ ---------------------------------------------------------GA- ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------R------------------- ------------------------------------------------------------ -----------ELPH--------------CPLWVSA------------------------ ------------------------------------------------------------ ------------------------------------------------------THLLQG QAWAKL--GAQKEAVSEFSRCLELLFRA-------------------------------- --------TPE-DR---------------EQ----------------------------- -----------------GA--------AS----------NCEQGCR-------------- ----------------------SDV------------------T---------------- -----------------------LQQL--------------------------------- --------------------------------------------RTAALISRGLQWVAS- ---------------------------------------------------------GHD AKALQDFLLGV------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------QICP------------------------ ----------------------------------------GNQDASFY------------ ---------------------------------------LLQTLWRQ------------- ----------------------------------------------------DRRDEAAA L---------------------W------------------------RRLEAQT-----K S-P----QEDAT----------W-------------S----------------------- ------------------LPLYLETC---------------------------------- -----------------------------------------------------LSWIRPS DRQTFLEE----------------------------------------FQVSV------- ------------------------------------------------------------ -------QEPRD-V------------------------ >ENSRNOP00000069926 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------M-----------SSQI------------------------ ----------IPSLPK---TF------------------------------SS------- ------SLDLWREKNDQLVRQAKQLT-RD------------------------------- ------------------------------------------SRPS-------------- ------------------------LRRQ-------------------------------- --------QSVQD---------------------------------------------TL EGFRELLLTL-------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------Q----------------------------------G--- -------------------------------------------LPAAVPALP-------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------LELTVTCNYIILRAS- -LAQGFTEDLTEDVQRGLER----------------------------------VLEAQH -QMG---SKSQQGLKEL---------------WHSV------------------------ ------------------------------------------------------------ ---------LSAPSLLPELLPALHCLAS-------------------------------- ------------------------------------------------------------ ---------------------------LHA------------------------------ ---------------------------ALWMSTNHLGDLTSL------------------ ---------------------------------------------------------LQT LNG----------------------SQ--------T---ETS------------------ --EDLLP-----LLKSWSPPVEK------------------------------------- -----------------------------------------------------LHAPLIL QDAESLKDVLL-------------------------------------------T----- ---------------AFACRQGF--------QELITGSL----------------PHAQS SLQEAASGLCPPSV------------------------------LVQVYTALGTCLRKMG ------------------------------------------------------------ ------SPQRAL-----LYLTEALKVGTTCALPLLE------------------------ ---------------------------------------------------------ASR VYRQLGDT----------AAELESLQLLVEALSAT----HS---SET------------- --------FTRL----------------------------------IEVEL--------- ------------------------------------------------------------ -------LLPQPDPASPLHCGT-------------------------------------- -------------------------------QSQAKHLL--------------------- --------------ASRCLQT--------------------------------------- ------------------------------------------------------------ -----GRAEA----------AAEHY----------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ LDL--------------------------------------------------------- ------------------------------------------------------------ -----LAMLL-DGS---------------------------------------------- -------------------------------------------------------EPR-- ------------------------------------------------------------ ---------------------------------------------S------S------- -----PPTSAL-GPCMPELCLEAAAALIQAGRASDA------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ LTVCV------------------------------------------------------- ---------------------------------------------------------ELL SRTSSL-----LPKMPSLW---------------------------ENASK--------- ------------------------------------------------------------ ---------------------------------------------------------RT- ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------K------------------- ------------------------------------------------------------ -----------ELPY--------------CPIWASA------------------------ ------------------------------------------------------------ ------------------------------------------------------THLLQG QAWSQL--KAQKEALSEFSQCLELLFRA-------------------------------- --------LPK-DK---------------EQ----------------------------- -----------------G----------S----------NCEQKCM-------------- ----------------------SDV------------------S---------------- -----------------------LKQL--------------------------------- --------------------------------------------RVAALISRGLEWVAI- ---------------------------------------------------------GQD TKALSDFLLSV------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------QICP------------------------ ----------------------------------------GNRDGSFY------------ ---------------------------------------LLQTLKRL------------- ----------------------------------------------------DRKNEASA F---------------------W------------------------R--EAQS-----Q L-P----QEEAA----------R-------------C----------------------- ------------------LPLYLETC---------------------------------- -----------------------------------------------------LNWIHPP NCEAFFEE----------------------------------------FGTAV------- ------------------------------------------------------------ -------LESCD-L------------------------ >ENSMUSP00000030165 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------M-----------SSQV------------------------ ----------IPALPK---TF------------------------------SS------- ------SLDLWREKNDQLVRQAKQLT-RD------------------------------- ------------------------------------------SRPS-------------- ------------------------LRRQ-------------------------------- --------QSAQD---------------------------------------------TL EGLRELLLTL-------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------Q----------------------------------G--- -------------------------------------------LPAAVPALP-------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------LELTVLCNCIILRAS- -LVQAFTEDLTQDLQRGLER----------------------------------VLEAQH -HLE---PKSQQGLKEL---------------WHSV------------------------ ------------------------------------------------------------ ---------LSASSLPPELLPALHCLAS-------------------------------- ------------------------------------------------------------ ---------------------------LQA------------------------------ ---------------------------VFWMSTDHLEDLTLL------------------ ---------------------------------------------------------LQT LNG----------------------SQ--------T---QSS------------------ --EDLLL-----LLKSWSPPAEE------------------------------------- -----------------------------------------------------SPAPLIL QDAESLRDVLL-------------------------------------------T----- ---------------AFACRQGF--------QELITGSL----------------PHAQS NLHEAASGLCPPSV------------------------------LVQVYTALGACLRKMG ------------------------------------------------------------ ------NPQRAL-----LYLTEALKVGTTCALPLLE------------------------ ---------------------------------------------------------ASR VYRQLGDR----------AAELESLELLVEALSAT----HS---SET------------- --------FKSL----------------------------------IEVEL--------- ------------------------------------------------------------ -------LLPQPDPASPLHCGT-------------------------------------- -------------------------------QSQAKHLL--------------------- --------------ASRCLQT--------------------------------------- ------------------------------------------------------------ -----GRAED----------AAEHY----------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ LDL--------------------------------------------------------- ------------------------------------------------------------ -----LAMLL-GGS---------------------------------------------- -------------------------------------------------------ETR-- ------------------------------------------------------------ ---------------------------------------------F------S------- -----PPTSSL-GPCIPELCLEAAAALIQAGRALDA------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ LTVCE------------------------------------------------------- ---------------------------------------------------------ELL NRTSSL-----LPKMSSLW---------------------------ENARK--------- ------------------------------------------------------------ ---------------------------------------------------------RA- ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------K------------------- ------------------------------------------------------------ -----------ELPC--------------CPVWVSA------------------------ ------------------------------------------------------------ ------------------------------------------------------THLLQG QAWSQL--KAQKEALSEFSQCLELLFRT-------------------------------- --------LPE-DK---------------EQ----------------------------- -----------------G----------S----------DCEQKCR-------------- ----------------------SDV------------------A---------------- -----------------------LKQL--------------------------------- --------------------------------------------RVAALISRGLEWVAS- ---------------------------------------------------------GQD TKALSDFLLSV------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------QICP------------------------ ----------------------------------------GNRDGSFY------------ ---------------------------------------LLQTLKRL------------- ----------------------------------------------------DRKNEASA F---------------------W------------------------R--EAHS-----Q L-P----LEDAA----------G-------------S----------------------- ------------------LPLYLETC---------------------------------- -----------------------------------------------------LSWIHPP NREAFLEE----------------------------------------FGTSV------- ------------------------------------------------------------ -------LESCV-L------------------------ >MGP_SPRETEiJ_P0064373 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------M-----------SSQV------------------------ ----------IPALPK---TF------------------------------SS------- ------SLDLWRGKNDQLVRQAKQLT-RD------------------------------- ------------------------------------------SRPS-------------- ------------------------LRRQ-------------------------------- --------QLAQD---------------------------------------------TL EGLRELLLTL-------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------Q----------------------------------G--- -------------------------------------------LPAAVPALP-------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------LELTVLCNCIILRAS- -LVQAFTEDLTQDLQRGLER----------------------------------VLEAQH -HLE---PKSQQGLKEL---------------WHSV------------------------ ------------------------------------------------------------ ---------LSASSLPPELLPALHCLAS-------------------------------- ------------------------------------------------------------ ---------------------------LQA------------------------------ ---------------------------VFWMSTDHLEDLTLL------------------ ---------------------------------------------------------LQT LNG----------------------SQ--------T---QSS------------------ --EDLLL-----LLKSWSPPAEE------------------------------------- -----------------------------------------------------SPAPLIL QDAESLRDVLL-------------------------------------------T----- ---------------AFACRQGF--------QELITGSL----------------PHAQS SLHEAASGLCPPSV------------------------------LVQVYTALGTCLRKMG ------------------------------------------------------------ ------NPQRAL-----LYLTEALKVGTTCALPLLE------------------------ ---------------------------------------------------------ASR IYRQLGDR----------AAELESLELLVEALSAT----HS---SET------------- --------FKSL----------------------------------IEVEL--------- ------------------------------------------------------------ -------LLPQPDPASPLHCGT-------------------------------------- -------------------------------QSQAKHLL--------------------- --------------ASRCLQT--------------------------------------- ------------------------------------------------------------ -----GRAED----------AAEHY----------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ LDL--------------------------------------------------------- ------------------------------------------------------------ -----LAMLL-GGS---------------------------------------------- -------------------------------------------------------ETR-- ------------------------------------------------------------ ---------------------------------------------F------S------- -----PPTSSL-GPCIPELCLEAAAALIQAGRALDA------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ LTVCE------------------------------------------------------- ---------------------------------------------------------ELL NRTSSL-----LPKMSSLW---------------------------ENARK--------- ------------------------------------------------------------ ---------------------------------------------------------RT- ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------K------------------- ------------------------------------------------------------ -----------ELPC--------------CPVWVSA------------------------ ------------------------------------------------------------ ------------------------------------------------------THLLQG QAWSQL--KAQKEALSEFSQCLELLFRT-------------------------------- --------LPE-DK---------------EQ----------------------------- -----------------G----------S----------DCEQKCR-------------- ----------------------SDV------------------A---------------- -----------------------LKRL--------------------------------- --------------------------------------------RVAALISRGLEWVAS- ---------------------------------------------------------GQD TKALSDFLLSV------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------QICP------------------------ ----------------------------------------GNRDGSFY------------ ---------------------------------------LLQTLKRL------------- ----------------------------------------------------DRKNEASA F---------------------W------------------------R--EAHS-----Q L-P----LEDAA----------G-------------S----------------------- ------------------LPLYLETC---------------------------------- -----------------------------------------------------LSWIHPP NREAFLEE----------------------------------------FGTSV------- ------------------------------------------------------------ -------LESCD-L------------------------ >MGP_CAROLIEiJ_P0061909 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------M-----------SSQV------------------------ ----------IPAFPK---TF------------------------------SS------- ------SLDLWREKNDQLVKQAKQLS-RD------------------------------- ------------------------------------------SRPS-------------- ------------------------LRRQ-------------------------------- --------QSAQN---------------------------------------------TL EGLRELLLTL-------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------Q----------------------------------G--- -------------------------------------------LPAAVPALP-------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------LELTVLCNCIILRAS- -LVQAFTEDLTQDLQRGLER----------------------------------VLEAQH -HLE---PKSQQGLKEL---------------WHSV------------------------ ------------------------------------------------------------ ---------LSASSLPPELLPALHCLAS-------------------------------- ------------------------------------------------------------ ---------------------------LQA------------------------------ ---------------------------VFWMSTDRLEDLSLL------------------ ---------------------------------------------------------LQT LNG----------------------SQ--------T---ETS------------------ --EDLLL-----LLKSWSPPAEE------------------------------------- -----------------------------------------------------SHAPLIL QDAQSLRDVLL-------------------------------------------T----- ---------------AFACRQGF--------QELITGSL----------------PHAQS SLHEAASGLCPPSV------------------------------LVQVYTALGTCLRKMG ------------------------------------------------------------ ------NPQRAL-----LYLTEALKVGTACALPLLE------------------------ ---------------------------------------------------------ASR VYRQLGDR----------AAELESLGLLVEALSAT----HS---SET------------- --------FKSL----------------------------------IEVES--------- ------------------------------------------------------------ -------LLPQPDPASPLHCGT-------------------------------------- -------------------------------QSQAKHLL--------------------- --------------ASRCLQT--------------------------------------- ------------------------------------------------------------ -----GRAED----------AAEHY----------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ LDL--------------------------------------------------------- ------------------------------------------------------------ -----LAMLL-GGS---------------------------------------------- -------------------------------------------------------ETR-- ------------------------------------------------------------ ---------------------------------------------F------S------- -----PPTSSL-GPCIPELCLEAAAALIQAGRALDA------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ LTVCE------------------------------------------------------- ---------------------------------------------------------ELL NRTSSL-----LPKMSSLW---------------------------ENARK--------- ------------------------------------------------------------ ---------------------------------------------------------RT- ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------K------------------- ------------------------------------------------------------ -----------ELPC--------------CPVWVSA------------------------ ------------------------------------------------------------ ------------------------------------------------------THLLQG QAWSQL--KAQKEALSEFSQCLELLFRT-------------------------------- --------LPE-DK---------------EQ----------------------------- -----------------G----------S----------DCEQKCR-------------- ----------------------SDV------------------A---------------- -----------------------LKQL--------------------------------- --------------------------------------------RVAALISRGLEWVAS- ---------------------------------------------------------GQD TKALSDFLLSV------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------QICP------------------------ ----------------------------------------GNRDGSFY------------ ---------------------------------------LLQTLRRL------------- ----------------------------------------------------ERKNEASV F---------------------W------------------------R--EARS-----Q L-P----QEDAA----------G-------------S----------------------- ------------------LPLYLETC---------------------------------- -----------------------------------------------------LSWIHPP NREAFLEE----------------------------------------FGTSV------- ------------------------------------------------------------ -------LESCD-L------------------------ >MGP_PahariEiJ_P0057633 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------M-----------SSQI------------------------ ----------IPAFPQ---TF------------------------------SS------- ------SLDLWREKNDQLVRQAKRLT-RD------------------------------- ------------------------------------------SRPS-------------- ------------------------LRRQ-------------------------------- --------QSAQD---------------------------------------------TL EGFRELLLTL-------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------R----------------------------------G--- -------------------------------------------LPAAVPALP-------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------LELTVLCNCIILRVS- -LAQGLTEDLTQELQRGLER----------------------------------VLEAQH -HLE---LKSQQGLKEL---------------WHSV------------------------ ------------------------------------------------------------ ---------LSAYPLPPELLPALHCLAS-------------------------------- ------------------------------------------------------------ ---------------------------LQA------------------------------ ---------------------------VSWMSTDRLQDLTLL------------------ ---------------------------------------------------------LQT LNG----------------------SQ--------T---ETS------------------ --EDLLL-----LLKSWSPPAEE------------------------------------- -----------------------------------------------------SHGPLIL QDAESLRGVLL-------------------------------------------T----- ---------------AFACRQGF--------QELSTGNL----------------PHAQS SLHEAASGLCPPSV------------------------------LVQVYTALGTCLRKMG ------------------------------------------------------------ ------NPQRAL-----LYLTEALKVGTTCALPLLE------------------------ ---------------------------------------------------------ASR VYRQLGDT----------AAELESLELLVEALSVT----HS---SET------------- --------FKSL----------------------------------IEVEL--------- ------------------------------------------------------------ -------LLPQPDPASPLHGGT-------------------------------------- -------------------------------RSQAKHLL--------------------- --------------ASRCLQM--------------------------------------- ------------------------------------------------------------ -----GRAED----------AAEHY----------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ LDL--------------------------------------------------------- ------------------------------------------------------------ -----LAVLL-GGS---------------------------------------------- -------------------------------------------------------EPR-- ------------------------------------------------------------ ---------------------------------------------F------S------- -----PPTSSL-GPCVPELCLEAAAALIQAGRASDA------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ LTVCE------------------------------------------------------- ---------------------------------------------------------ELL NRTSSL-----LPKMSSLW---------------------------ENARK--------- ------------------------------------------------------------ ---------------------------------------------------------RT- ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------K------------------- ------------------------------------------------------------ -----------ELPC--------------CPVWVSA------------------------ ------------------------------------------------------------ ------------------------------------------------------THLLQG QAWSRL--KAQKEALSEFSQCLELLFRT-------------------------------- --------LPE-DK---------------EQ----------------------------- -----------------G----------S----------GCEQKCR-------------- ----------------------SDV------------------A---------------- -----------------------LRQL--------------------------------- --------------------------------------------RVAALISRGLEWVAS- ---------------------------------------------------------GQD TKALNDFLLSV------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------QTCP------------------------ ----------------------------------------GNRDGSFY------------ ---------------------------------------LLQTLKRL------------- ----------------------------------------------------DRKNEASA F---------------------W------------------------R--EAHS-----Q L-P----QEDAA----------G-------------S----------------------- ------------------LPLYLETC---------------------------------- -----------------------------------------------------LSWIHPP NREAFLEE----------------------------------------FGTSV------- ------------------------------------------------------------ -------LESCD-L------------------------ >ENSMOCP00000004061 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------M-----------SSQI------------------------ ----------IPALPK---T-------------------------------SS------- ------ILDLWREKNDRLVRQAKQLT-GD------------------------------- ------------------------------------------SRPS-------------- ------------------------LRRQ-------------------------------- --------QLAQD---------------------------------------------TL EGFKELLITL-------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------Q----------------------------------G--- -------------------------------------------LPAAVPALP-------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------LELTVTCNYIILRAS- -LAQDFTEDLTQDIQRALER----------------------------------VLETQN -QLE---PKSQQRLPEL---------------WHSV------------------------ ------------------------------------------------------------ ---------LSASSLLPELLPALYCLAS-------------------------------- ------------------------------------------------------------ ---------------------------LQA------------------------------ ---------------------------ILWMSTNHPGDLALL------------------ ---------------------------------------------------------LQT LNA----------------------SQ--------T---ETS------------------ --EDLLL-----LLKSWSPPAEK------------------------------------- -----------------------------------------------------ADAPLSI QNAESLRDVLL-------------------------------------------T----- ---------------AFACRQGL--------QELITGSL----------------PRALS SLHEAASGLCPPSV------------------------------LVQVYTALGTCLRKMG ------------------------------------------------------------ ------NPQRAL-----LYLTAALKVGATCALPLLE------------------------ ---------------------------------------------------------ASR IYRQLGDT----------AAELESLELLAEALSAP----HSPIHSST------------- --------LKLV----------------------------------IEVEL--------- ------------------------------------------------------------ -------LLPQPGPASPLHCGT-------------------------------------- -------------------------------QSQAKHLL--------------------- --------------ASRCLQT--------------------------------------- ------------------------------------------------------------ -----GRAED----------ASEHY----------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ LDL--------------------------------------------------------- ------------------------------------------------------------ -----LAMLL-GGS---------------------------------------------- -------------------------------------------------------EPG-- ------------------------------------------------------------ ---------------------------------------------F------S------- -----PPTSST-GPCIPELCLEAAAALIQAGRAQDA------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ LTVCE------------------------------------------------------- ---------------------------------------------------------ELL SRTSSL-----LPKM-SLW---------------------------ENARK--------- ------------------------------------------------------------ ---------------------------------------------------------RA- ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------K------------------- ------------------------------------------------------------ -----------ELPY--------------CPFWVSA------------------------ ------------------------------------------------------------ ------------------------------------------------------THLLQG QAWSQL--KAQKEALSEFSQCLELLFRA-------------------------------- --------LPE-DK---------------EQ----------------------------- -----------------G----------S----------NCEQKCR-------------- ----------------------PDV------------------T---------------- -----------------------LKHL--------------------------------- --------------------------------------------QVAALLSRGLEWAAS- ---------------------------------------------------------NQD TKALSDFLLSV------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------QICP------------------------ ----------------------------------------GNRDGSFY------------ ---------------------------------------LLQTLKRL------------- ----------------------------------------------------ERKNEAAA F---------------------W------------------------Q--KAQT-----Q P-A----QEEAT----------W-------------S----------------------- ------------------LPLYLETC---------------------------------- -----------------------------------------------------LSWIHPP NCEALLEE----------------------------------------FGTSL------- ------------------------------------------------------------ -------LESCD-L------------------------ >ENSPEMP00000006928 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------M-----------CSQI------------------------ ----------LPALPQ---TS------------------------------SS------- ------SLDLWREKNDRLVGQTRQLI-GD------------------------------- ------------------------------------------SRPS-------------- ------------------------LRRQ-------------------------------- --------QLAQD---------------------------------------------TL EGFRELLLTL-------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------Q----------------------------------G--- -------------------------------------------LPAALPALP-------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------LELTVTCNYIILRAS- -LAQGFTEDLIKDVQRGLER----------------------------------VMETQN -QLE---PKSQQGLQEL---------------WHSV------------------------ ------------------------------------------------------------ ---------LSASSLLPELLPTLHCLAS-------------------------------- ------------------------------------------------------------ ---------------------------LQA------------------------------ ---------------------------VLWMRTDCSGDLALL------------------ ---------------------------------------------------------LQA LNG----------------------SQ--------T---ETS------------------ --EDLLL-----LLKSWSPPAEK------------------------------------- -----------------------------------------------------SDGPLIL QDAQGLRDVLL-------------------------------------------T----- ---------------ALACRQGL--------QELITGSL----------------PRALN SLHEAASGLCPPSV------------------------------LVQVYTALGTCLRKMG ------------------------------------------------------------ ------NPQRAL-----LYLTAALKVGTTCALPLLE------------------------ ---------------------------------------------------------ASR IYRQLGDT----------AAELESLELLVEALSAT----HGP---KM------------- --------LRLL----------------------------------IEVEL--------- ------------------------------------------------------------ -------LLPQPDPASPLHCGT-------------------------------------- -------------------------------QSQAKHLL--------------------- --------------ASRCLQT--------------------------------------- ------------------------------------------------------------ -----GRAGD----------AAEHY----------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ LDL--------------------------------------------------------- ------------------------------------------------------------ -----LAVLLGGGS---------------------------------------------- -------------------------------------------------------EPR-- ------------------------------------------------------------ ---------------------------------------------V------S------- -----PPTCSP-GPCVPELCLEAAAALIQAGRAPDA------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ LTVCG------------------------------------------------------- ---------------------------------------------------------ELL SRTSCL-----LPKM-SVW---------------------------ENARK--------- ------------------------------------------------------------ ---------------------------------------------------------RT- ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------K------------------- ------------------------------------------------------------ -----------GLPY--------------CPLWVSA------------------------ ------------------------------------------------------------ ------------------------------------------------------THLLQG QAWSQL--KAQKEALSEFSQCLELLFRV-------------------------------- --------LPE-DK---------------EQ----------------------------- -----------------G----------S----------SCEQKCR-------------- ----------------------PDV------------------V---------------- -----------------------LKQL--------------------------------- --------------------------------------------QVAALLSRGLEWAAS- ---------------------------------------------------------GQD TKALSDFLLSV------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------QICP------------------------ ----------------------------------------GNRDGSFY------------ ---------------------------------------LLQTLKRS------------- ----------------------------------------------------KRKNEATA F---------------------W------------------------R--EAQT-----R A-P----QEEAT----------W-------------S----------------------- ------------------LPLYLETC---------------------------------- -----------------------------------------------------LSWIHPP NCEALLEE----------------------------------------FGTSL------- ------------------------------------------------------------ -------LESHD-L------------------------ >ENSMAUP00000013640 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------M-----------SGQI------------------------ ----------TSTLPQ---TS------------------------------SS------- ------SLDLWREKNNRLVEQARQLT-GD------------------------------- ------------------------------------------SRLS-------------- ------------------------LRRQ-------------------------------- --------QLAQD---------------------------------------------TL EEFGELLLTL-------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------Q----------------------------------G--- -------------------------------------------LPASVPALP-------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------LELTVICNYIILKAS- -LAQGFTEDLTQDVQRGVER----------------------------------VLETQN -QLE---PKSQQGLQGL---------------WHSV------------------------ ------------------------------------------------------------ ---------LSASSLLPELLPALHCLAS-------------------------------- ------------------------------------------------------------ ---------------------------LQA------------------------------ ---------------------------ILWMSTDHLGDLALL------------------ ---------------------------------------------------------LKT LNG----------------------IQ--------T---ETS------------------ --EDLLL-----LLKSWSPPAEK------------------------------------- -----------------------------------------------------SDAPLIL QDAEGLRDVLL-------------------------------------------T----- ---------------ALACHQGL--------QELITGNL----------------PQALS RLHEAASGVCPPSV------------------------------LAQVYTALGTCQRKMG ------------------------------------------------------------ ------NPQRAL-----LYLTAALKVGVTCALPLLE------------------------ ---------------------------------------------------------ASR LYRQLGDT----------AAELESLQLLVEAL--------SATPSSA------------- --------LKLH----------------------------------IEVEL--------- ------------------------------------------------------------ -------LLPQPDPSSPLYCGT-------------------------------------- -------------------------------QSQAKRLL--------------------- --------------ASRCLQT--------------------------------------- ------------------------------------------------------------ -----GRAED----------AAEHY----------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ LDL--------------------------------------------------------- ------------------------------------------------------------ -----LAVLL-GGS---------------------------------------------- -------------------------------------------------------ELR-- ------------------------------------------------------------ ---------------------------------------------S------S------- -----PPTSSP-GPCIPELCLEAAAALIQAGRAPDA------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ LTVCE------------------------------------------------------- ---------------------------------------------------------ELL SRTSSL-----LPKM-SLW---------------------------ENARK--------- ------------------------------------------------------------ ---------------------------------------------------------RT- ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------K------------------- ------------------------------------------------------------ -----------ELPY--------------CPIWVSA------------------------ ------------------------------------------------------------ ------------------------------------------------------THLLQG QAWSQL--KARKEALSEFSQCLELLFRA-------------------------------- --------LPE-DK---------------EQ----------------------------- -----------------G----------S----------NCEQKCQ-------------- ----------------------PDV------------------A---------------- -----------------------LKQL--------------------------------- --------------------------------------------QVATLLSRGLEWVAS- ---------------------------------------------------------GQD TKALSDFLLSV------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------QICP------------------------ ----------------------------------------GNRDGSFY------------ ---------------------------------------LLQTLKRL------------- ----------------------------------------------------ERRSEATA F---------------------W------------------------R--EAQN-----Q Q-L----QENAT----------R-------------S----------------------- ------------------LPLYLETC---------------------------------- -----------------------------------------------------LSWIHPP NCEAFLKE----------------------------------------FGASL------- ------------------------------------------------------------ -------LESRD-L------------------------ >ENSCGRP00001021341 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------M--------------------------------------- -----------SALSQ---TS------------------------------SS------- ------TLDLWKDKNDRLVEQARQLT-GG------------------------------- ------------------------------------------SRLS-------------- ------------------------LRRQ-------------------------------- --------QLAQD---------------------------------------------TL EGFRELLLTL-------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------Q----------------------------------G--- -------------------------------------------LPAAVPALP-------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------LELTVICNYIILGAS- -LAQGFTEDLTQDVQRGLER----------------------------------VLETQS -QLE---PKLQQGLQGL---------------WHSV------------------------ ------------------------------------------------------------ ---------LSASSLLPKLLPALHCLAS-------------------------------- ------------------------------------------------------------ ---------------------------LQA------------------------------ ---------------------------IFWMCTDHLGDLALL------------------ ---------------------------------------------------------LQT LNG----------------------IQ--------T---ETS------------------ --EDLLL-----LIKSWSPPPEK------------------------------------- -----------------------------------------------------SDAPLIL QDAEGLRDVLL-------------------------------------------T----- ---------------TLACRQGL--------QELITGSL----------------PRALS RLHEAASGVCPPSV------------------------------LVQVYTALGTCLRKMG ------------------------------------------------------------ ------NPQRAL-----LYLTAALKVGTTCALPLLE------------------------ ---------------------------------------------------------ASR IYRQLGDT----------AAELESLELLVEALSAT----HSATHSST------------- --------LKFH----------------------------------IEVEL--------- ------------------------------------------------------------ -------LLPKPDPASPLHCGT-------------------------------------- -------------------------------QSQAKRLL--------------------- --------------ASRCLQT--------------------------------------- ------------------------------------------------------------ -----GRAED----------AAEHY----------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ LDL--------------------------------------------------------- ------------------------------------------------------------ -----LAMLL-GSS---------------------------------------------- -------------------------------------------------------EPR-- ------------------------------------------------------------ ---------------------------------------------F------S------- -----LPTSSP-GPCIPELCLEAAAALIQASRAPDA------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ LTVCE------------------------------------------------------- ---------------------------------------------------------ELL SRISSL-----IPKT-SLW---------------------------ENARK--------- ------------------------------------------------------------ ---------------------------------------------------------RT- ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------K------------------- ------------------------------------------------------------ -----------ELPY--------------CPIWISA------------------------ ------------------------------------------------------------ ------------------------------------------------------THLLQG QAWSQL--KARKEALSEFSQCLELLFRA-------------------------------- --------LPE-DK---------------EQ----------------------------- -----------------G----------S----------NCEQKCW-------------- ----------------------PDV------------------A---------------- -----------------------LKQL--------------------------------- --------------------------------------------QVAALLSRGLEWIAS- ---------------------------------------------------------GQD TKALSDFLLSV------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------QICP------------------------ ----------------------------------------GNRDGSFY------------ ---------------------------------------LLQTLKRL------------- ----------------------------------------------------ERRNEAAA F---------------------W------------------------R--EAQN-----Q P-L----QEEAT----------W-------------S----------------------- ------------------LPLYLETC---------------------------------- -----------------------------------------------------LSWIHPP NCEALLKE----------------------------------------FGTSL------- ------------------------------------------------------------ -------------L------------------------ >ENSCGRP00015004074 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------M--------------------------------------- -----------SALSQ---TS------------------------------SS------- ------TLDLWKDKNDRLVEQARQLT-GG------------------------------- ------------------------------------------SRLS-------------- ------------------------LRRQ-------------------------------- --------QLAQD---------------------------------------------TL EGFRELLLTL-------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------Q----------------------------------G--- -------------------------------------------LPAAVPALP-------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------LELTVICNYIILGAS- -LAQGFTEDLTQDVQRGLER----------------------------------VLETQS -QLE---PKLQQGLQGL---------------WHSV------------------------ ------------------------------------------------------------ ---------LSASSLLPKLLPALHCLAS-------------------------------- ------------------------------------------------------------ ---------------------------LQA------------------------------ ---------------------------IFWMCTDHLGDLALL------------------ ---------------------------------------------------------LQT LNG----------------------IQ--------T---ETS------------------ --EDLLL-----LIKSWSPPPEK------------------------------------- -----------------------------------------------------SDAPLIL QDAEGLRDVLL-------------------------------------------T----- ---------------TLACRQGL--------QELITGSL----------------PRALS RLHEAASGVCPPSV------------------------------LVQVYTALGTCLRKMG ------------------------------------------------------------ ------NPQRAL-----LYLTAALKVGTTCALPLLE------------------------ ---------------------------------------------------------ASR IYRQLGDT----------AAELESLELLVEALSAT----HSATHSST------------- --------LKFH----------------------------------IEVEL--------- ------------------------------------------------------------ -------LLPKPDPASPLHCGT-------------------------------------- -------------------------------QSQAKRLL--------------------- --------------ASRCLQT--------------------------------------- ------------------------------------------------------------ -----GRAED----------AAEHY----------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ LDL--------------------------------------------------------- ------------------------------------------------------------ -----LAMLL-GSS---------------------------------------------- -------------------------------------------------------EPR-- ------------------------------------------------------------ ---------------------------------------------F------S------- -----LPTSSP-GPCIPELCLEAAAALIQASRAPDA------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ LTVCE------------------------------------------------------- ---------------------------------------------------------ELL SRISSL-----IPKT-SLW---------------------------ENARK--------- ------------------------------------------------------------ ---------------------------------------------------------RT- ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------K------------------- ------------------------------------------------------------ -----------ELPY--------------CPIWISA------------------------ ------------------------------------------------------------ ------------------------------------------------------THLLQG QAWSQL--KARKEALSEFSQCLELLFRA-------------------------------- --------LPE-DK---------------EQG---------------------------- ----------------AG----------S----------NCEQKCW-------------- ----------------------PDV------------------A---------------- -----------------------LKQL--------------------------------- --------------------------------------------QVAALLSRGLEWIAS- ---------------------------------------------------------GQD TKALSDFLLSV------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------QICP------------------------ ----------------------------------------GNRDGSFY------------ ---------------------------------------LLQTLKRL------------- ----------------------------------------------------ERRNEAAA F---------------------W------------------------R--EAQN-----Q P-L----QEEAT----------W-------------S----------------------- ------------------LPLYLETC---------------------------------- -----------------------------------------------------LSWIHPP NCEALLKE----------------------------------------FGTSL------- ------------------------------------------------------------ -------------L------------------------ >ENSMUGP00000023727 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------M-----------SSQV------------------------ ----------VPALPR---PF------------------------------SS------- ------NLDLWREKNDGLVGQARQLT-KD------------------------------- ------------------------------------------SRSS-------------- ------------------------LRRQ-------------------------------- --------QLAQD---------------------------------------------TL EGFGELLLTL-------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------Q----------------------------------G--- -------------------------------------------LPAAVPALP-------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------LELTVICNYIILRAS- -LAQDFTEDLSQDVQRGLER----------------------------------VLETQN -QLG---PKSQPRLREL---------------WDSV------------------------ ------------------------------------------------------------ ---------LSASSLLPELLPALHCLAS-------------------------------- ------------------------------------------------------------ ---------------------------LQA------------------------------ ---------------------------VLWMSTDHLGDLTSL------------------ ---------------------------------------------------------LQT LNG----------------------SQ--------T------------------------ --EDLLV-----LLKSWNPPAQK------------------------------------- -----------------------------------------------------SLAPLML QDAEGLRDVLL-------------------------------------------T----- ---------------SFACRQGL--------QELVTGSL----------------SRAQR SLHEAASGVCPPSV------------------------------LVQVYTALGTCLRQMG ------------------------------------------------------------ ------NPQRAL-----LYLTEALKVGVACALPLLE------------------------ ---------------------------------------------------------ASR VYRQLGDT----------AAELDSLGLLVEALSAT----HS---SET------------- --------LKLF----------------------------------IEVEL--------- ------------------------------------------------------------ -------LLPQPDPASPLYCGT-------------------------------------- -------------------------------QSQAKHLL--------------------- --------------ASRCLQT--------------------------------------- ------------------------------------------------------------ -----GRAAD----------AAEHY----------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ LDL--------------------------------------------------------- ------------------------------------------------------------ -----LAMLL-GSS---------------------------------------------- -------------------------------------------------------EPR-- ------------------------------------------------------------ ---------------------------------------------L------S------- -----PPTSSP-GSCLPELYLEAAAALIQAGRALDA------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ LTVCE------------------------------------------------------- ---------------------------------------------------------ELL SRTSSL-----LPKTSSLW---------------------------ENARK--------- ------------------------------------------------------------ ---------------------------------------------------------RT- ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------K------------------- ------------------------------------------------------------ -----------ELPY--------------CPIWVSA------------------------ ------------------------------------------------------------ ------------------------------------------------------THLLQG QAWSKL--KAQKEALSDFSQCLELVFRV-------------------------------- --------LPK-DK----------------Q----------------------------- -----------------G----------S----------TCEQKCS-------------- ----------------------SDV------------------A---------------- -----------------------LQQL--------------------------------- --------------------------------------------QVTALISRGLEWVAS- ---------------------------------------------------------GQD NKALRDFLLSV------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------QICP------------------------ ----------------------------------------GNRDGSFY------------ ---------------------------------------LLQTLKRL------------- ----------------------------------------------------DRKNEAIA F---------------------W------------------------R--EAQT-----Q Q-P----QEEAA----------W-------------S----------------------- ------------------LPLYLETC---------------------------------- -----------------------------------------------------LSWIRPP NCEVFLEE----------------------------------------FGTAL------- ------------------------------------------------------------ -------LESCD-L------------------------ >ENSJJAP00000001163 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------M-----------SRQT------------------------ ----------FPGFSE---PP------------------------------AS------- ------CLDLWRNKNDQLVQRAKQVT-LD------------------------------- ------------------------------------------TRVS-------------- ------------------------LRRQ-------------------------------- --------QLAQD---------------------------------------------TL EGLRKLLHIL-------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------Q----------------------------------G--- -------------------------------------------LPAAVPALL-------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------LELTVTCNFIILRTN- -LTRSFTEDQIQDIKWGLER----------------------------------VLETQK -QKG---PKLGQGLREL---------------WVSV------------------------ ------------------------------------------------------------ ---------LHASSLAPELLPVLHNLAS-------------------------------- ------------------------------------------------------------ ---------------------------LQA------------------------------ ---------------------------ALWLSTDHLEDLAFL------------------ ---------------------------------------------------------LKT LNG----------------------HQ--------T---GAS------------------ --EDLLL-----LLKSWSPPAEE------------------------------------- -----------------------------------------------------SDAPLTL QNAQTMRDVLL-------------------------------------------T----- ---------------AFAYRQGL--------QELITESL----------------PSALK SLHEAASGLCPRPL------------------------------LVQVYTAVGFCLRKMG ------------------------------------------------------------ ------NPQRAL-----LYLTEALKRGPTWGPPLLE------------------------ ---------------------------------------------------------ASR VYRQLGDV----------AAELESLELLVEALSTT----PS---PEA------------- --------PQLL----------------------------------IEVEL--------- ------------------------------------------------------------ -------LLPQPDPASPLHCGT-------------------------------------- -------------------------------QSQAKHLL--------------------- --------------ASRCLQT--------------------------------------- ------------------------------------------------------------ -----GRAED----------ASEHY----------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ LDL--------------------------------------------------------- ------------------------------------------------------------ -----LALLL-DGS---------------------------------------------- -------------------------------------------------------EPR-- ------------------------------------------------------------ ---------------------------------------------F------T------- -----PSPGSS-GPCVPEMFLEAAAALIQAGRAQDA------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ LTVCQ------------------------------------------------------- ---------------------------------------------------------ELL SRTSSL-----LPKMSWLW---------------------------EDARK--------- ------------------------------------------------------------ ---------------------------------------------------------RT- ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------K------------------- ------------------------------------------------------------ -----------VLPY--------------CPLWVSA------------------------ ------------------------------------------------------------ ------------------------------------------------------THLLQG QAWVQL--KAQKEALSEFSQCLELLFRA-------------------------------- --------LPK-DK---------------EQ----------------------------- -----------------G----------S----------NCEQEGE-------------- ----------------------SNV------------------V---------------- -----------------------LQQL--------------------------------- --------------------------------------------RAAALISRGLEWVAS- ---------------------------------------------------------GQD TRALKDFLLSV------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------QICP------------------------ ----------------------------------------GHRSGSLY------------ ---------------------------------------LLQTLKRL------------- ----------------------------------------------------DRMNEATA F---------------------W------------------------Q--EAQT-----Q L-P----QEQAT----------W-------------S----------------------- ------------------LPLYLETY---------------------------------- -----------------------------------------------------LNWIHSS DCETLLEE----------------------------------------FQTSV------- ------------------------------------------------------------ -------LEPHD-L------------------------ >ENSNGAP00000001208 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------M-----------SHLI------------------------ ----------IPAVPK---AP------------------------------AS------- ------CLDLWRQKNDRLVHQARQLA-RD------------------------------- ------------------------------------------TSPS-------------- ------------------------LRRQ-------------------------------- --------RLAQD---------------------------------------------IL EKFRGLLHTL-------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------Q----------------------------------G--- -------------------------------------------LPAAVPALP-------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------LELTVTCNFIILRAS- -LAQGFPEDLTQDIQRSLER----------------------------------VLETQN -QLG---PKLEQGLKEL---------------WNSV------------------------ ------------------------------------------------------------ ---------LHSSSLLPELLPALHCLAS-------------------------------- ------------------------------------------------------------ ---------------------------LQA------------------------------ ---------------------------ALWLSTDHLGDLALL------------------ ---------------------------------------------------------LQT LNG----------------------SQ--------T---EAS------------------ --ENLLL-----LLKSWSSPAEM------------------------------------- -----------------------------------------------------SDAPLTL QNASALRDVVL-------------------------------------------T----- ---------------AFAYRQGF--------QELITGNL----------------PSALS SLHEAASGLCPQPM------------------------------LVQVYTALGTCLRKMG ------------------------------------------------------------ ------SPQKAL-----LYLTAALKVGTTWAPPLLE------------------------ ---------------------------------------------------------ASR LYRQLGDT----------SAELESLKLLAEALSAT----HN---PEA------------- --------PKLL----------------------------------IEVDL--------- ------------------------------------------------------------ -------LLPQPDPASPLHCGT-------------------------------------- -------------------------------QSQAKYLL--------------------- --------------ASRCLQA--------------------------------------- ------------------------------------------------------------ -----GRAEE----------AAEHY----------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ LDL--------------------------------------------------------- ------------------------------------------------------------ -----LALLL-DGS---------------------------------------------- -------------------------------------------------------EPR-- ------------------------------------------------------------ ---------------------------------------------F------S------- -----PPPSPS-GPCMPELFLEAAAALIQAGRPQDA------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ LTVCE------------------------------------------------------- ---------------------------------------------------------ELL SRTSSL-----LPKMSWLQ---------------------------ENVRK--------- ------------------------------------------------------------ ---------------------------------------------------------GT- ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------R------------------- ------------------------------------------------------------ -----------KLPH--------------CPLWVSA------------------------ ------------------------------------------------------------ ------------------------------------------------------THLLQG QAWSQL--KAPKEALSEFSQCLELLFQA-------------------------------- --------VPK-DK---------------EQ----------------------------- -----------------G----------ST----YEDLYSC------------------- ----------------------SDV------------------A---------------- -----------------------LQQL--------------------------------- --------------------------------------------RVAALISRGLEWVSS- ---------------------------------------------------------SQD TKALNDFLLSV------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------QICP------------------------ ----------------------------------------GNRDGSVY------------ ---------------------------------------LLQTLKRL------------- ----------------------------------------------------DRKNEATA F---------------------W------------------------R--EAQT-----H L-L----KEEAA----------W-------------S----------------------- ------------------VPLYLETY---------------------------------- -----------------------------------------------------LSWLHPP NCETLLEE----------------------------------------FQTSL------- ------------------------------------------------------------ -------LESHD-L------------------------ >ENSPCIP00000029199 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------M-----------PRVSPSRLPLLVSALPAWLDVGSGEALR NIRAVAGEQDVPRLPRAPDSP----G---------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------LP------------------------------------------------- ------------------------------------------------------------ ------------------------GP-------------------VEG------------ ------------------------------------------------------------ ----------------------------------GKRST--------------------- ---------GP--------AVE----------------------------------G--- -------------------------------------------LPSALSVLP-------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------LELTVLGNTLTLEVS- -LAQRFMKDHALDIQRGLER----------------------------------VLNAQG -MPL---PQE----GDL---------------WKTI------------------------ ------------------------------------------------------------ ---------FQNPFIPSEMLSPLHHLLG-------------------------------- ------------------------------------------------------------ ---------------------------LQG------------------------------ ---------------------------AMWLTDNRPGDLAIL------------------ ---------------------------------------------------------LCA MMN----------------------SQ--------Y---KESGVPLLG------------ LTEDLLS-----LLSVWDPCFEE------------------------------------- -----------------------------------------------------LDAPLTL QDARSLRDVLL-------------------------------------------T----- ---------------TAAFHQGL--------QELHVGNL----------------PLALS SLQKAAFSLCPRSV------------------------------LTQVHTALGACLRKMG ------------------------------------------------------------ ------HPQRAL-----LHLLEALKADPGQGPPLLE------------------------ ---------------------------------------------------------AAR LYRQLGHT----------ASELESLKLLVEALSIP----HS---PRT------------- --------PLFS----------------------------------IGVEL--------- ------------------------------------------------------------ -------LITPPSPASSLYCGT-------------------------------------- -------------------------------QSQVKHML--------------------- --------------ASRCLQT--------------------------------------- ------------------------------------------------------------ -----GRNEE----------AVEQY----------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ LDL--------------------------------------------------------- ------------------------------------------------------------ -----LALLL-DGSM--------------------------------------------- -------------------SQGMQCSVFLSG---------------------GSQAPR-- ------------------------------------------------------------ ------------------------------------------------------------ ---------------VPEVFLETAAALIIVGRFQDS------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ LTVCE------------------------------------------------------- ---------------------------------------------------------ELL SRISLL-----VPQ--KLWL----GQGGPSLRPVLSTVPPLSENPSEDL----------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------F--------------CLLWASA------------------------ ------------------------------------------------------------ ------------------------------------------------------AHLLQG QAHSGL--GARKEALEEFSRCLELLFRV-------------------------------- --------QPL-DRV-------------VDQ----------------------------- -----------------GA--------GG----------DIDQGLS-------------- ----------------------GDV-ISSSEDELPSEICLHRKV---------------- -----------------------LQRL--------------------------------- --------------------------------------------KAVTLISRGLEWVAE- ---------------------------------------------------------GQD ARALQDFLLGV------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------QVCP------------------------ ----------------------------------------GDRNASLH------------ ---------------------------------------LLRVLWRL------------- ----------------------------------------------------ERREEAVA T---------------------Y------------------------QRLEAEA-----D Q-E----QGDSE----------G-------------L----------------------- ------------------LPQYLESC---------------------------------- -----------------------------------------------------MNRIQIT EQESLLQE----------------------------------------LRKSL------- ------------------------------------------------------------ -------QRPTC-P------------------------ >ENSMODP00000009639 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------M--------------------------------------- -------------------SP----GSAAPL------------------EHPG------- ------CLGLWKAENDRLVRQWRVVA-QD------------------------------- ------------------------------------------SGQP-------------- ------------------------L-KQ-------------------------------- --------QAVHH---------------------------------------------VL EEFRGLLHKL-------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------Q----------------------------------G--- -------------------------------------------LPSALSVLP-------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------LELTVLGNSLTLGVG- -LVQGFMKDHVLNIQQSLER----------------------------------VLNAQG -VPL---PKS----GDL---------------WGAI------------------------ ------------------------------------------------------------ ---------FQSPFIPSEMLPPLHHLVG-------------------------------- ------------------------------------------------------------ ---------------------------LQG------------------------------ ---------------------------ALWLTDNHPGDLIIL------------------ ---------------------------------------------------------LRT VMS----------------------SQ--------C---KESGAHLPG------------ LTEDLLS-----LLHAWDPPIEV------------------------------------- -----------------------------------------------------PDAPLAL QDARSLKDVLL-------------------------------------------T----- ---------------TAAFHQGL--------HELHMENL----------------SLALS SLQKAAFSPCPRPV------------------------------LVLVHTALGACLRKMG ------------------------------------------------------------ ------HPQRAL-----LHLLEALKAGLTPGPPLLE------------------------ ---------------------------------------------------------AAR LYRQLGHT----------TAELDSLKLLVEALSIP----HS---SRP------------- --------PLFP----------------------------------LGVEL--------- ------------------------------------------------------------ -------LITALRPASSLSCGT-------------------------------------- -------------------------------QSQAKHLL--------------------- --------------ASRCLQT--------------------------------------- ------------------------------------------------------------ -----GRGEE----------AVEQY----------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ LDL--------------------------------------------------------- ------------------------------------------------------------ -----LALLL-DGSM--------------------------------------------- -------------------LQGMKYSVTLPG---------------------GSPASR-- ------------------------------------------------------------ ------------------------------------------------------------ ---------------VPDVFLETATALILVARFQDS------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ LTVCE------------------------------------------------------- ---------------------------------------------------------ELL SRIAPL-----VPQ--KLWL----GQGEPSLRPALSPVPPRPEDPSEHL----------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------F--------------YLLWASA------------------------ ------------------------------------------------------------ ------------------------------------------------------AHLLQG QAHSGL--GARREALEEFSRCLELLFRV-------------------------------- --------QPM-DRV-------------VDE----------------------------- -----------------GA--------DG----------DVDQGLS-------------- ----------------------RDVIISSAEDELPSKICSPVKV---------------- -----------------------LQKL--------------------------------- --------------------------------------------KVVALISRGLEWVAE- ---------------------------------------------------------GRD ARALQDFLLAV------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------QLCP------------------------ ----------------------------------------GDRRASLH------------ ---------------------------------------LLYVLWRL------------- ----------------------------------------------------ERREEAAA I---------------------C------------------------QRLEAEA-----D Q-Y----QDNSE----------G-------------L----------------------- ------------------LPLYLESC---------------------------------- -----------------------------------------------------VNRIPIT EQESLLRE----------------------------------------LQKSL------- ------------------------------------------------------------ -------QRPTC-S------------------------ >ENSGAGP00000011282 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------M--------------------------------------- ------------------------------------------------------------ ---------------AQRLRP--------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ RAFDSLLRKI-------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------Q----------------------------------G--- -------------------------------------------LPAALPSLS-------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------LELTVLYNSLLFAVS- -ESDGLVEGEAERINHGLIR----------------------------------VLEACG -VSG---QDL--STEEL---------------WQKV------------------------ ------------------------------------------------------------ ---------LQDVT-TEELCAPLHRLGA-------------------------------- ------------------------------------------------------------ ---------------------------LQG------------------------------ ---------------------------AVWLAANCLGSVTGL------------------ ---------------------------------------------------------FRL LSD----------------------TKDP-L----PSAHGGE------------------ --NELLA-----LLKAWSVPVEG------------------------------------- -----------------------------------------------------DTSPLVV QSTKDLKEILW-------------------------------------------T----- ---------------SAAFLQGL--------QGLEAGNL----------------PTALS LLQAAASGFCSKRV------------------------------LAQIYTSIGCCTQQMG ------------------------------------------------------------ ------KPQTAL-----QHLKRALQVDFQCLSALSQ------------------------ ---------------------------------------------------------AAL VYRQLGET----------DAELEALALLYKALETPAQ-ETV---SID------------- --------PCFL----------------------------------IRTEL--------- ------------------------------------------------------------ -------LVHTPALASLFSRSH-------------------------------------- -------------------------------PSEVKYLL--------------------- --------------AQRCLQA--------------------------------------- ------------------------------------------------------------ -----GRVAE----------AVEHY----------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ LDL--------------------------------------------------------- ------------------------------------------------------------ -----LALLQ-EGP---------------------------------------------- -------------------------------------------------------QHQ-- ------------------------------------------------------------ ---------------------------------------------V------P------- -----LHGRSA-LPRIPEVFLEAASALEQLGRHQDA------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ IAVCE------------------------------------------------------- ---------------------------------------------------------EII SRTDDL-----IPETLRIEL---------------------------------------- ------------------------------------------------------------ ----------------------------DSSAGGEAPGRAG--------SPSPGIPPQQ- ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------R------------------- ------------------------------------------------------------ -----------ESLR--------------CIVWRAA------------------------ ------------------------------------------------------------ ------------------------------------------------------AYLHQG WAWTRL--GESKEAITRFTRCLNVLLRVQ-----------LVSTAS------------IH SSEEMAEALPE-AK---------------------------------------------- ------------------------------------------------------------ -------------------------------------------V---------------- -----------------------LQKI--------------------------------- --------------------------------------------RLLALLGRGSQFQEL- ---------------------------------------------------------GRD KEALMNFQHSL------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------QVCP------------------------ ----------------------------------------GDPAATSH------------ ---------------------------------------LLRTLWKL------------- ----------------------------------------------------NRRQEAAA L---------------------W------------------------QKLHADA-----P P-A----DGQQE----------APGR----------P----------------------- ------------------YPLYLVSC---------------------------------- -----------------------------------------------------LKQVNLP HDESLARS----------------------------------------LQDYLRTS---- ------------------------------------------------------------ -------GQD---P------------------------ >ENSCABP00000009145 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------MHPASLLLHWSLT--------------------------- ------------------------------------------------------------ ---------------A-------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------------------G--- -------------------------------------------LPAALPSLS-------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------LELTVLYNSLLFAVS- -ESDGLVEGEAERINHGLIR----------------------------------VLEACG -VSG---QDL--STEEL---------------WQKV------------------------ ------------------------------------------------------------ ---------LQDVT-TEELCAPLHRLGA-------------------------------- ------------------------------------------------------------ ---------------------------LQG------------------------------ ---------------------------AVWLAANCLGSVTGL------------------ ---------------------------------------------------------FRL LSD----------------------TKDP-L----PAAHGGE------------------ --NELLV-----LLKAWSVPVEG------------------------------------- -----------------------------------------------------DTSPLVV QSTKDLKEILW-------------------------------------------T----- ---------------SAAFLQGL--------QGLEAGNL----------------PTALS LLQAAASGFCSKRV------------------------------LAQIYTSIGCCTQQMG ------------------------------------------------------------ ------KPQTAL-----QHLKRALQVDFQCLSALSQ------------------------ ---------------------------------------------------------AAL VYRQLGET----------DAELEALALLYKALETPAQ-EAV---SID------------- --------PCFL----------------------------------IRTEL--------- ------------------------------------------------------------ -------LVHTPALASLFSRSH-------------------------------------- -------------------------------PSEVKYLL--------------------- --------------AQRCLQA--------------------------------------- ------------------------------------------------------------ -----GRVAE----------AVEHY----------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ LDL--------------------------------------------------------- ------------------------------------------------------------ -----LALLQ-EGP---------------------------------------------- -------------------------------------------------------QHQ-- ------------------------------------------------------------ ---------------------------------------------V------P------- -----LHGRSA-LPRIPEVFLEAASALEQLGRHQDA------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ IAVCE------------------------------------------------------- ---------------------------------------------------------EII SRTDDL-----IPETLRIEL---------------------------------------- ------------------------------------------------------------ ----------------------------DSSAGGEAPGRAG--------SPSLGIPPQQ- ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------R------------------- ------------------------------------------------------------ -----------ESLR--------------CIVWRAA------------------------ ------------------------------------------------------------ ------------------------------------------------------AYLHQG WAWARL--GESKEAITRFTRCLNVLLRVQ-----------LVSAAS------------IH SSEEMAEALPE-AK---------------------------------------------- ------------------------------------------------------------ -------------------------------------------V---------------- -----------------------LQKI--------------------------------- --------------------------------------------RLLALLGRGSQFQEL- ---------------------------------------------------------GRD KEALMNFQHSL------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------QVCP------------------------ ----------------------------------------GDPAATSH------------ ---------------------------------------LLRALWKL------------- ----------------------------------------------------NRRQEAAA L---------------------W------------------------QKLHADA-----A P-A----DGQQE----------APGR----------P----------------------- ------------------YPLYLVSC---------------------------------- -----------------------------------------------------LKQVSLP HDESLAGS----------------------------------------LQDYLRTS---- ------------------------------------------------------------ -------GQD---P------------------------ >ENSCPBP00000025201 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------MSPASLLLHWSLT--------------------------- ------------------------------------------------------------ ---------------A-------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------------------G--- -------------------------------------------LPAALPSLS-------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------LELTVLYNSLLFAVS- -ESDGLVEGEAERINHGLIR----------------------------------VLEACG -VSG---QDL--STEEL---------------WQKV------------------------ ------------------------------------------------------------ ---------LQDVT-TEELCAPLHRLGA-------------------------------- ------------------------------------------------------------ ---------------------------LQG------------------------------ ---------------------------AVWLAANCLGSVTGL------------------ ---------------------------------------------------------FRL LSD----------------------TKGP-L----PSAHGGE------------------ --NELLA-----LLKAWSVPVEG------------------------------------- -----------------------------------------------------DTSPLVV QSTKDLKEILW-------------------------------------------T----- ---------------SAAFLQGL--------QGLEAGNL----------------PTALS LLQAAASGFCSKRV------------------------------LAQIYTCIGCCTQQMG ------------------------------------------------------------ ------KPQTAL-----QHLKRALQVDFQCLSALSQ------------------------ ---------------------------------------------------------AAL VYRQLGET----------DAELEALALLYKALETPAQ-EAV---SID------------- --------PCFL----------------------------------IRTEL--------- ------------------------------------------------------------ -------LVHTPALASLFSRSH-------------------------------------- -------------------------------PSEVKYLL--------------------- --------------AQRCLQA--------------------------------------- ------------------------------------------------------------ -----GRVGE----------AVEHY----------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ LDL--------------------------------------------------------- ------------------------------------------------------------ -----LALLQ-EGP---------------------------------------------- -------------------------------------------------------QHQ-- ------------------------------------------------------------ ---------------------------------------------V------P------- -----LHGRSA-LPRIPEVFLEAASALEQLGRYQDA------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ IAVCE------------------------------------------------------- ---------------------------------------------------------EII SRTDDL-----IPETLRIEL---------------------------------------- ------------------------------------------------------------ ----------------------------DSGAGGEAPGRAG--------SPSPGIPPQQ- ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------R------------------- ------------------------------------------------------------ -----------ESLR--------------CIVWRAA------------------------ ------------------------------------------------------------ ------------------------------------------------------AYLHQG RAWARL--GESKEAITRFTRCLNVLLRVQ-----------LVSAAS------------IQ SGEKMAEALPE-AK---------------------------------------------- ------------------------------------------------------------ -------------------------------------------V---------------- -----------------------LQKI--------------------------------- --------------------------------------------RLLALLGRGSQFQEL- ---------------------------------------------------------GRD KEALMNFQHSL------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------QVCP------------------------ ----------------------------------------GDPAATSH------------ ---------------------------------------LLRALWKL------------- ----------------------------------------------------NRRQEAAA L---------------------W------------------------QKLHADA-----A P-A----DGQQE----------APGR----------P----------------------- ------------------YPLYLVSC---------------------------------- -----------------------------------------------------LKQVNLP HDESLARS----------------------------------------LQDYLRTS---- ------------------------------------------------------------ -------GQD---P------------------------ >ENSCPRP00005022181 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------M-----------ERL------------------------- ------------------------------------------------------------ ----------WAGDCAQLVRSWRVAS---------------------------------- ------LSG-----------------------------------SG-------------- ------------------------RATK-------------------------------- --------QAVLQ---------------------------------------------HR RAFEKLLQKI-------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------Q----------------------------------G--- -------------------------------------------LPAVLPSLP-------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------LELTVLYNSLLFDLG- -SSDCIVEREPEGIRQGLLR----------------------------------VLEAGG -VSG---QDL--STEEL---------------WQKV------------------------ ------------------------------------------------------------ ---------LQEVP-AEELRAPLHQLGV-------------------------------- ------------------------------------------------------------ ---------------------------LQG------------------------------ ---------------------------VLWLAANRLGSITGL------------------ ---------------------------------------------------------LRL LSG----------------------AKEP-VLSPCP---GGE------------------ --NELLA-----LLRAWQVPADG------------------------------------- -----------------------------------------------------GTSPLVV QSARDVREILW-------------------------------------------T----- ---------------AAAFLQGF--------QELEAGNL----------------PAALS LLQLAATGFCSKRV------------------------------LAQIYICLGCCTRQMG ------------------------------------------------------------ ------KPQTAL-----QHLKQALQLDFQCLTALSQ------------------------ ---------------------------------------------------------AAM VYHQLGEM----------DAELEALALL-------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------HEA-----LDSPPPEAGSAASGSLVQTELLVHPLA---- -----------------LVSLL-----RQPSPSEVKYLL--------------------- --------------AQRCLQA--------------------------------------- ------------------------------------------------------------ -----GRTAE----------AGEHY----------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ LDL--------------------------------------------------------- ------------------------------------------------------------ -----LAVLQ-EGP---------------------------------------------- -------------------------------------------------------RHQ-- ------------------------------------------------------------ ---------------------------------------------V------P------- -----LHSQSA-LPRIPEVFLEAACALEQLGRHRDT------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ IAVCE------------------------------------------------------- ---------------------------------------------------------EVV SRTSDL-----TPEMLRIDLSSWDGAEAGS---------------SS-------PRP--- ------------------------------------------------------------ ----------------------RSGLSCD-------------------------ILPQK- ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------K------------------- ------------------------------------------------------------ -----------ESLR--------------CILWRAA------------------------ ------------------------------------------------------------ ------------------------------------------------------AYLHQG RAWAGL--ADSKEAITQFTRCLNDLLRVQ-----------LVSADG------------LH IGEVAAGALPE-AA---------------------------------------------- ------------------------------------------------------------ -------------------------------------------V---------------- -----------------------LQKI--------------------------------- --------------------------------------------RLLALVGRGTQFLEL- ---------------------------------------------------------GRD RDALMNFQYAL------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------QVSP------------------------ ----------------------------------------GDLAAASH------------ ---------------------------------------LLQTLWKL------------- ----------------------------------------------------DRRQEAAA L---------------------W------------------------QKLQADS-----G Q-T----EGQQE----------VPGR----------S----------------------- ------------------FPLYLTLC---------------------------------- -----------------------------------------------------PQPTNLL LDGSLARS----------------------------------------LQDYLGSS---- ------------------------------------------------------------ -------SQK---P------------------------ >ENSNPEP00000006915 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------MGSCPPSSP------------------------------------------ -------------------------------------------------CS--------- -----------------------QAP-------------------SHGT-----FPGFHC SPSKSRLEALGGG----------------------------------------------- -----------------------WRAGQ----GSGTRSVPLAQSIPVLVS---------- --------------------LT----------------------------------G--- -------------------------------------------LPAALATLP-------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------LELTVLYNSLVFAMG- -ASDCAINGEAEEIRQGLLR----------------------------------VLEACG -AAG---QDL--STEKL---------------WQKV------------------------ ------------------------------------------------------------ ---------LQEVT-VEELQAPLHRLAA-------------------------------- ------------------------------------------------------------ ---------------------------LQA------------------------------ ---------------------------AWWLATNRLGSVTGL------------------ ---------------------------------------------------------FRL LSS----------------------AEHP-GRAPCS---EGK------------------ --TQLLS-----LLRAWKVPAEE------------------------------------- -----------------------------------------------------ASLSL-V QSAQDLKEVLC-------------------------------------------T----- ---------------AAAFLQGL--------QELEAGNL----------------PAALS LLQEAAGGFCSKRL------------------------------LAQIYTCLSCCTQRMG ------------------------------------------------------------ ------KPQTAL-----QHLKRALQVDFQCLPALSR------------------------ ---------------------------------------------------------AAA LYRELGEV----------DAELQALALLCEALERNPP-AAA---SPP------------- --------PCCL----------------------------------IQTEQ--------- ------------------------------------------------------------ -------LVHTPALSALLRHRH-------------------------------------- -------------------------------LSEVKYLL--------------------- --------------AQRCLED--------------------------------------- ------------------------------------------------------------ -----GRMAD----------AVEHY----------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ LDF--------------------------------------------------------- ------------------------------------------------------------ -----LSLLQ-DGL---------------------------------------------- -------------------------------------------------------QQQ-- ------------------------------------------------------------ ---------------------------------------------V------P------- -----LDAGSA-LPRLPEVLLEAASALQQAGRPQDA------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ITVCE------------------------------------------------------- ---------------------------------------------------------EVV GRTASL-----IPQTLRVE---------------------------ERLEQPECPSP--- ------------------------------------------------------------ ----------------------EPQLA-------------------------AGPLSQK- ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------R------------------- ------------------------------------------------------------ -----------ESLR--------------CLVWRTA------------------------ ------------------------------------------------------------ ------------------------------------------------------AYLHQG WAWAQL--DETKEAVTQFSRCLSDLLRVQLYQPGVETAGSL------------------- --------LPE-VK---------------------------------------------- ------------------------------------------------------------ -------------------------------------------L---------------- -----------------------LQKI--------------------------------- --------------------------------------------RLLSLIGRGAQFLEL- ---------------------------------------------------------GKL KEALLDFQYGL------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------QISP------------------------ ----------------------------------------GDPAAASY------------ ---------------------------------------LVQALWKL------------- ----------------------------------------------------DRKQEAAA R---------------------W------------------------QKLSESP-----A E-E----AGQQE----------GLGR----------P----------------------- ------------------CPLYLVSC---------------------------------- -----------------------------------------------------LKQATFP QNESLARD----------------------------------------LQDYLQS----- ------------------------------------------------------------ ----------TN-S------------------------ >ENSARWP00000024279 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------M-----------KRRR------------------------ -------------------------RGEVPEP--------------------G------- ------CLRAWAAESEALAGRWRAAR---------------------------------- ------CWG-----------------------------------PG-------------- ------------------------GAAA-------------------------------- ----------ARQ---------------------------------------------QR GAFGELLLRM-------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------R----------------------------------G--- -------------------------------------------LPAALTTLP-------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------LELTVLYNSLLFAMG- -ASDCAINGEAEEIRQGLLR----------------------------------VLEACG -ASG---QDL--STEEL---------------WQKV------------------------ ------------------------------------------------------------ ---------LQEVT-VEELQAPLHRLGA-------------------------------- ------------------------------------------------------------ ---------------------------LQG------------------------------ ---------------------------AWWLATNRLGSITSL------------------ ---------------------------------------------------------FRL LSN----------------------AEDP-GRAPCS---GGK------------------ --NELLS-----LLKAWRVPAEG------------------------------------- -----------------------------------------------------DSVSL-V QSAEDLKEILC-------------------------------------------T----- ---------------AAAFLQGL--------QELEAGNL----------------PAALS LLQEAAGGFCSKRV------------------------------LAQIYTCLSCCTRQMG ------------------------------------------------------------ ------KPQTAL-----QHLKRALQVDFQCLPALSH------------------------ ---------------------------------------------------------AAA VYHELGET----------DAELQALAVLYEALERNPP-AAA---STT------------- --------PYCL----------------------------------IQTEH--------- ------------------------------------------------------------ -------LVHTPALASLFRHRH-------------------------------------- -------------------------------PSEVKYLL--------------------- --------------AQRCLQD--------------------------------------- ------------------------------------------------------------ -----GRVAD----------AVEHY----------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ LDF--------------------------------------------------------- ------------------------------------------------------------ -----LALLQ-DGL---------------------------------------------- -------------------------------------------------------QQQ-- ------------------------------------------------------------ ---------------------------------------------V------P------- -----LDGGSA-LPRIPEVFLEAASALEQAGRHQDA------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ITVCE------------------------------------------------------- ---------------------------------------------------------EVV SRTADL-----IPQTLRVE---------------------------EGPEQLECPSP--- ------------------------------------------------------------ ----------------------GTELA-------------------------GGPLSQK- ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------R------------------- ------------------------------------------------------------ -----------ESLC--------------CLVWRTA------------------------ ------------------------------------------------------------ ------------------------------------------------------AYLHQG WAWAKL--GKKKEAITQFSRCLEDLLRVQLYRSGVEPTGSL------------------- --------LPE-VK---------------------------------------------- ------------------------------------------------------------ -------------------------------------------L---------------- -----------------------LQEI--------------------------------- --------------------------------------------RLLSLIGRGTQFLEL- ---------------------------------------------------------GRH REALLDFQHGL------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------QISP------------------------ ----------------------------------------GDPAAASY------------ ---------------------------------------LVQALWKL------------- ----------------------------------------------------NRKQEAAA R---------------------W------------------------QKLSESP-----A E-E----DGQQE----------GLGRR--------------------------------- ------------------YPLYLVSC---------------------------------- -----------------------------------------------------LKQAAFP HNESLAGN----------------------------------------IQDYLRT----- ------------------------------------------------------------ ----------TT-S------------------------ >ENSDNVP00000017104 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------M-------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------R----------------------------------G--- -------------------------------------------LPAALTTLP-------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------LELTVLYNSLLFAMG- -ASDCAINGESEEICQGLLR----------------------------------VLEALG -ASG---QDL--STEEL---------------WQKV------------------------ ------------------------------------------------------------ ---------LQEVT-VEELQAPLHRLGA-------------------------------- ------------------------------------------------------------ ---------------------------LQG------------------------------ ---------------------------AWWLATNRLGSITGL------------------ ---------------------------------------------------------FRL LSS----------------------AEDP-GRAPCS---GGK------------------ --NELLS-----LLKAWKVPAEG------------------------------------- -----------------------------------------------------ASVSL-V QSAEDLKEILC-------------------------------------------T----- ---------------AAAFLQGL--------QELEAGNL----------------PAALS LLEEAAGGFCSKRV------------------------------LAQIYTCLSCCTQQMG ------------------------------------------------------------ ------KPQTAL-----QHLKRALQVDFQCLPALSH------------------------ ---------------------------------------------------------AAA VYHELGEM----------DAELEALAVLYEALERNPP-AAA---STT------------- --------PYCL----------------------------------IQIEH--------- ------------------------------------------------------------ -------LVHTPALASLFRHRH-------------------------------------- -------------------------------PSEVKYLL--------------------- --------------AQRCLQD--------------------------------------- ------------------------------------------------------------ -----GRVAD----------AVEHY----------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ LDF--------------------------------------------------------- ------------------------------------------------------------ -----LALLQ-DGL---------------------------------------------- -------------------------------------------------------QQQ-- ------------------------------------------------------------ ---------------------------------------------V------P------- -----LDGGSA-LPRIPEVFLEAASALEQAGRHQDA------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ITVCE------------------------------------------------------- ---------------------------------------------------------EVV SRTADL-----IPQVLRVE---------------------------ERSEQPECPSP--- ------------------------------------------------------------ ----------------------GTELA-------------------------GGPLSQK- ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------R------------------- ------------------------------------------------------------ -----------ESLC--------------CLVWRTA------------------------ ------------------------------------------------------------ ------------------------------------------------------AYLHQG WAWAML--GKNKEAITQFSRCLGDLLRIQLYQSGVEPTGSL------------------- --------IPE-VN---------------------------------------------- ------------------------------------------------------------ -------------------------------------------L---------------- -----------------------LQKI--------------------------------- --------------------------------------------RLLSLVGRGTQFLEL- ---------------------------------------------------------GKH REALLDFQHGL------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------QISP------------------------ ----------------------------------------GDPAAASY------------ ---------------------------------------LVQALWKL------------- ----------------------------------------------------NRKQEAAA R---------------------W------------------------QKLSESP-----A E-E----DGQQE----------GLGRRVA------RP----------------------- ------------------YPLYLVSC---------------------------------- -----------------------------------------------------LKQATFP HNESLARN----------------------------------------IQDYLRT----- ------------------------------------------------------------ ----------AT-T------------------------ >ENSPMJP00000006198 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------M-----------KRRR------------------------ --------------------------GTEPEP----------------ERERS------- ------CLRAWAAHSRALVGRWTTAR---------------------------------- ------CGGEAPQVR--------------------------------------------- ------------------------------------------------------------ -----------RQ---------------------------------------------QR DEFRELLLSI-------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------R----------------------------------G--- -------------------------------------------LPAALPALP-------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------LELTVLYNSLLFTVG- -ASDSAIKGEAEGIRQGLLR----------------------------------VLEACG -ACG---QDL--GTEEL---------------WEKV------------------------ ------------------------------------------------------------ ---------LQEVT-VEELQAPLHRLGA-------------------------------- ------------------------------------------------------------ ---------------------------LQA------------------------------ ---------------------------AWWLAASQLRSVAGL------------------ ---------------------------------------------------------FRL LST----------------------AKDP-ERAHCS---EGQ------------------ --NELLS-----MIKAWRVPPEE------------------------------------- -----------------------------------------------------TSLPL-V QSAKDLKEILW-------------------------------------------T----- ---------------AAAFLQGL--------QELEAGNF----------------STALS LLQEAAGGFCSKKI------------------------------LAQIYTCLGCCAQRMG ------------------------------------------------------------ ------KPQTAL-----QHLKRALQVDFQCLPALSH------------------------ ---------------------------------------------------------VAA VYHDLGET----------NAELQALTLLYKALGKNPP-AAA---SSS------------- --------PCFL----------------------------------MRTEL--------- ------------------------------------------------------------ -------LVHTPVLTSLLRQHH-------------------------------------- -------------------------------PSEVKYLL--------------------- --------------AQRCLQD--------------------------------------- ------------------------------------------------------------ -----GRVAD----------AVEHY----------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ LDF--------------------------------------------------------- ------------------------------------------------------------ -----LSLLQ-EGL---------------------------------------------- -------------------------------------------------------QQQ-- ------------------------------------------------------------ ---------------------------------------------M------P------- -----LDGSSA-LPRIPEVFLEAASALEQAGRHQDA------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ITLCE------------------------------------------------------- ---------------------------------------------------------EVI RRTTDH-----IPRVLRVE---------------------------ESLQHPECSLP--- ------------------------------------------------------------ ----------------------GAELA-------------------------GALLSQ-- ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------K------------------- ------------------------------------------------------------ -----------ESLC--------------CLAWRAA------------------------ ------------------------------------------------------------ ------------------------------------------------------GYLHQG WARAKL--GESKEAITQFSRCLSDLLRVQLHGSGIKQTENL------------------- --------QPE-VE---------------------------------------------- ------------------------------------------------------------ -------------------------------------------V---------------- -----------------------LQKI--------------------------------- --------------------------------------------RLLSLIGRGTQFLEL- ---------------------------------------------------------GRH KEALLDFQHSL------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------QISP------------------------ ----------------------------------------GDPGAASY------------ ---------------------------------------LVQALWKL------------- ----------------------------------------------------NRKQEAAA Q---------------------W------------------------QKFSQSS-----S G-Q----DEQQQ----------GQGR----------P----------------------- ------------------LPLYLVSC---------------------------------- -----------------------------------------------------LEQAMFP HSEPLARS----------------------------------------IQDYLRAA---- ------------------------------------------------------------ -------AQDTS-S------------------------ >ENSTGUP00000001827 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------------------G--- -------------------------------------------LPAALPALP-------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------LELTALYNSLLFTVG- -ASDSVVKGEAEGIRQGLFR----------------------------------VLEACG -ACG---EDL--GTEEL---------------WEKV------------------------ ------------------------------------------------------------ ---------LQEVT-MEELQAPLHRLGA-------------------------------- ------------------------------------------------------------ ---------------------------LQA------------------------------ ---------------------------AWWLAASQLGSVAGL------------------ ---------------------------------------------------------FQL LST----------------------AKDL-GRAHCS---EGQ------------------ --NELLS-----MIKAWQVPPEE------------------------------------- -----------------------------------------------------ASLPL-V QSAKDLKEILC-------------------------------------------T----- ---------------AAAFLQGL--------QELEAGNL----------------PAALS LLQEAAGGFCSKNI------------------------------LAQIYTCLGCCAQRMG ------------------------------------------------------------ ------KPQTAL-----QHLKRALQADFQCLPALSH------------------------ ---------------------------------------------------------MAT VYHKLGDT----------DAELQALTLLYEALGKNPP-AAA---SSS------------- --------PYFL----------------------------------MRTEL--------- ------------------------------------------------------------ -------LVHAPVLTSLLRHHY-------------------------------------- -------------------------------PSEVKYLL--------------------- --------------AQRCLQD--------------------------------------- ------------------------------------------------------------ -----GRVAD----------AVEHY----------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ LDF--------------------------------------------------------- ------------------------------------------------------------ -----LSLLQ-EGL---------------------------------------------- -------------------------------------------------------QQQ-- ------------------------------------------------------------ ---------------------------------------------V------P------- -----MDGSSA-LPRIPEVFLEAASALEQAGRHQDA------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ITVCE------------------------------------------------------- ---------------------------------------------------------EVI SRTTDL-----IPRVLRVE---------------------------ERLEQTESSLP--- ------------------------------------------------------------ ----------------------GAELV-------------------------GGFLSKK- ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------K------------------- ------------------------------------------------------------ -----------ESMC--------------CLAWRAA------------------------ ------------------------------------------------------------ ------------------------------------------------------GYLQQG WAWAKL--GESKEAVTQFSRCLSDLLRVQLHGSGVKQTENL------------------- --------QPE-VE---------------------------------------------- ------------------------------------------------------------ -------------------------------------------V---------------- -----------------------LQKI--------------------------------- --------------------------------------------RLLSLIGRGTQFLEL- ---------------------------------------------------------GRN KEALLDFQHSL------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------QISP------------------------ ----------------------------------------GDPAAASY------------ ---------------------------------------LVQTLWKM------------- ----------------------------------------------------NRKQEAAA Q---------------------W------------------------LKFSESS-----P G-D----DGQQP----------GQGR----------P----------------------- ------------------LPLYLVSC---------------------------------- -----------------------------------------------------LEQAVFP HSESLAGS----------------------------------------IQDFLGAA---- ------------------------------------------------------------ -------TQDTP-S------------------------ >ENSLSDP00000018663 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------M-----------KRRR------------------------ --------------------------GTEPEP----------------EPERG------- ------CLRAWAARSRALVERWT------------------------------------- -------------VRHVLF-----------------------PSP--------------- ------------------------------------------------------------ ----------FRE---------------------------------------------P- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------R----------------------------------G--- -------------------------------------------LPAALPALP-------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------LELTVLYNSLLFTVG- -ASDSVIKGEAEGIRQGLLR----------------------------------VLEACG -ACG---EDL--GTEEL---------------WEKV------------------------ ------------------------------------------------------------ ---------LQEVT-VEELQAPLHRLGA-------------------------------- ------------------------------------------------------------ ---------------------------LQA------------------------------ ---------------------------AWWLAASRLGSVAGL------------------ ---------------------------------------------------------FQL LST----------------------AEDL-GRAHCS---EGQ------------------ --NKLLS-----IIKAWQVPPEE------------------------------------- -----------------------------------------------------ASLPL-V QSAKDLKEILC-------------------------------------------T----- ---------------AAAFLQGL--------QELEAGNF----------------PAALS LLQEAAGGFCSKNI------------------------------LAQIYTCLGCCAQRMG ------------------------------------------------------------ ------KPQTAL-----QHLKQALQVDFQCLPALSH------------------------ ---------------------------------------------------------VAA VYHKLGET----------GVELQALTLLYEALGKNPP-AAA---SSS------------- --------PYFL----------------------------------MRTEL--------- ------------------------------------------------------------ -------LVHTPVLTSLLRRHH-------------------------------------- -------------------------------PSEVKYLL--------------------- --------------AQRCLQD--------------------------------------- ------------------------------------------------------------ -----GRVAD----------AVEHY----------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ LDF--------------------------------------------------------- ------------------------------------------------------------ -----LSLLQ-EGL---------------------------------------------- -------------------------------------------------------QQQ-- ------------------------------------------------------------ ---------------------------------------------V------P------- -----LDGSSA-LPRIPEVFLEAASALEQAGRHQDA------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ITVCE------------------------------------------------------- ---------------------------------------------------------EVI SRTTDL-----IPRVLRVE---------------------------ERLEQRESSLP--- ------------------------------------------------------------ ----------------------GAELV-------------------------GGFLSQK- ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------K------------------- ------------------------------------------------------------ -----------ESMC--------------CLAWRAA------------------------ ------------------------------------------------------------ ------------------------------------------------------GYLQQG WAWAKL--GESKEAVTQFSRCLSDLLRVQLHGSGVKQTENL------------------- --------QPE-VE---------------------------------------------- ------------------------------------------------------------ -------------------------------------------V---------------- -----------------------LQKI--------------------------------- --------------------------------------------RLLSLIGRGTQFLEL- ---------------------------------------------------------GKN KKALLDFQHSL------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------QISP------------------------ ----------------------------------------GDPAAASY------------ ---------------------------------------LVQTLWKM------------- ----------------------------------------------------NRKQEAAA Q---------------------W------------------------LKLSQSS-----P G-D----NGQQP----------GQGR----------P----------------------- ------------------LPLYLVSC---------------------------------- -----------------------------------------------------LEQAVFP HSESLARS----------------------------------------IQDFLGAA---- ------------------------------------------------------------ -------AQDTP-S------------------------ >ENSFALP00000010196 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------RQ---------------------------------------------QR DEFRELLLSI-------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------R----------------------------------G--- -------------------------------------------LPAALPALP-------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------LELTVLYNFLLFTVG- -ASDSAIKGEAEGIRQGLLR----------------------------------VLEACG -ACG---EDL--GTEEL---------------WEKV------------------------ ------------------------------------------------------------ ---------LQEVT-VEELQAPLQRLGA-------------------------------- ------------------------------------------------------------ ---------------------------LQA------------------------------ ---------------------------AWWLAASRLGSVAGL------------------ ---------------------------------------------------------FHL LST----------------------AEDL-GRSHCS---EGQ------------------ --NELLS-----VIKAWQVPPEG------------------------------------- -----------------------------------------------------ASLPL-V QSAKDLKEILC-------------------------------------------T----- ---------------AAAFLQGL--------QELEAGNF----------------PAALS LLQEAAGGFCSKKI------------------------------LAQIYTCLGCCAQRMG ------------------------------------------------------------ ------KPHTAL-----QHLKRALQVDFQCLPALSH------------------------ ---------------------------------------------------------VAA VYHELGET----------DAELQALTLFYEALGKNPP-AAA---SSS------------- --------PYFL----------------------------------MRTEL--------- ------------------------------------------------------------ -------LVHTPVLSSLLRHHH-------------------------------------- -------------------------------PSEVKYLL--------------------- --------------AQRCLQD--------------------------------------- ------------------------------------------------------------ -----GRVAD----------AVEHY----------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ LDF--------------------------------------------------------- ------------------------------------------------------------ -----LSLLQ-EGL---------------------------------------------- -------------------------------------------------------QQQ-- ------------------------------------------------------------ ---------------------------------------------V------P------- -----LDGSSA-LPRIPEVFLEAASALGQAGRHQDA------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ITVCE------------------------------------------------------- ---------------------------------------------------------EVI SRTTDL-----IPRVLRVE---------------------------ERLEQPECAVP--- ------------------------------------------------------------ ----------------------GAELV-------------------------GGLLSQK- ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------K------------------- ------------------------------------------------------------ -----------ENLC--------------CLAWRAA------------------------ ------------------------------------------------------------ ------------------------------------------------------GYLHQG WAWARL--GESKEAVTQFSRCLSDLLRVQLHGSGVRQTENI------------------- --------QPE-VE---------------------------------------------- ------------------------------------------------------------ -------------------------------------------V---------------- -----------------------LQKI--------------------------------- --------------------------------------------RLLALIGRGTQFLEL- ---------------------------------------------------------GRH KQALLDFQYSL------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------QLSP------------------------ ----------------------------------------GDPAAASY------------ ---------------------------------------LVQTLWML------------- ----------------------------------------------------NRKQEAAA Q---------------------W------------------------QKFSQSC-----P G-E----DRQQQ----------GQGR----------P----------------------- ------------------LPLYLVSC---------------------------------- -----------------------------------------------------LEQAVFP HSEPLARS----------------------------------------IQDYLGAA---- ------------------------------------------------------------ -------AQDTS-S------------------------ >ENSZALP00000009991 M----------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------AAAM-----------KRRR------------------------ --------------------------GTDPDPDPDPGPGPGPGPEPEREPERG------- ------CLRAWAAQSRAVVGRWTTAR---------------------------------- ------CGGETRRVC--------------------------------------------- ------------------------------------------------------------ -----------RQ---------------------------------------------LR DELLELLRSI-------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------R----------------------------------G--- -------------------------------------------LPVALPALP-------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------LELTVLYNSLLFTVG- -ASDSVIKGEAEGIRQGLLR----------------------------------VLEACG -ACG---QDL--GTEEL---------------WEKV------------------------ ------------------------------------------------------------ ---------LQEVT-VEELQAPLRRLGA-------------------------------- ------------------------------------------------------------ ---------------------------LQA------------------------------ ---------------------------AWWLAASQLASVAGL------------------ ---------------------------------------------------------FQL LST----------------------AEDR-GRAHCS---EGQ------------------ --NKLLS-----LIKAWRVPPEG------------------------------------- -----------------------------------------------------ASLPL-V QSAKDLKEILH-------------------------------------------T----- ---------------AAAFLQGL--------QELEAGNF----------------PTALS LLQEAAGGFCSKNI------------------------------LAQIHTCLGCCAQRMG ------------------------------------------------------------ ------KPQTAL-----QHLKRALQVDFQCLPALSH------------------------ ---------------------------------------------------------VAA VYHDLGEI----------DTGLQALTLLYEALGKSPP-PAA---SSA------------- --------PHFL----------------------------------MQTEL--------- ------------------------------------------------------------ -------LVHTPVLTSLLRRCH-------------------------------------- -------------------------------PSEVKYLL--------------------- --------------AQWCLQD--------------------------------------- ------------------------------------------------------------ -----GRVAD----------AVEHY----------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ LDF--------------------------------------------------------- ------------------------------------------------------------ -----LSLLQ-EGL---------------------------------------------- -------------------------------------------------------QQQ-- ------------------------------------------------------------ ---------------------------------------------V------P------- -----LDSSSA-LPRIPEVFLEAASALEQAGRHQDA------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ITVCE------------------------------------------------------- ---------------------------------------------------------EVI SRTTDL-----IPRVLRVE---------------------------ERLEQPESSLP--- ------------------------------------------------------------ ----------------------GAELA-------------------------GGLLSQK- ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------K------------------- ------------------------------------------------------------ -----------ESLC--------------CLAWRAA------------------------ ------------------------------------------------------------ ------------------------------------------------------GYLHQG WAWAKL--GESKEAVTQFSRCLSDLLRVQLHGSGIRQTENL------------------- --------QAE-VE---------------------------------------------- ------------------------------------------------------------ -------------------------------------------V---------------- -----------------------LQKI--------------------------------- --------------------------------------------RFLSLIGRGTQFLEM- ---------------------------------------------------------GRN KEALLDFQHSL------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------QISP------------------------ ----------------------------------------GDPAAASY------------ ---------------------------------------LVQALWEL------------- ----------------------------------------------------NRKQEAAA Q---------------------W------------------------QKFSQSC-----P A-E----DGQQQ----------GQGR----------P----------------------- ------------------LPLYLVSC---------------------------------- -----------------------------------------------------QEQAVFP HSETLARS----------------------------------------IQDYLRAA---- ------------------------------------------------------------ -------AQDTP-R------------------------ >ENSMVIP00005019254 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------M-----------KRRR------------------------ --------------------------EEAPGP----------GQDTEREQERD------- ------CLRFWTAHGWALAERWT------------------------------------- -------------VRHGPFLPCPGPRAPGPRRPAKFLAGLAVPT---------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------------------G--- -------------------------------------------LPVALPTLP-------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------LELTVLYNSLLFTLG- -ASDSAIEGQADGIRQGLLR----------------------------------VLEACG -ACG---QDL--STEEL---------------WQKV------------------------ ------------------------------------------------------------ ---------LQEVT-VEELQAPLHRLGA-------------------------------- ------------------------------------------------------------ ---------------------------LQA------------------------------ ---------------------------AWWLAAGRLGSIAGL------------------ ---------------------------------------------------------FRL LST----------------------AEDT-GRGRCS---EGQ------------------ --NELLS-----LLKTWQVPAEG------------------------------------- -----------------------------------------------------ACLPL-V QSAEDLKEILC-------------------------------------------T----- ---------------AAAFLQGL--------QELEAGNF----------------PTALS LLQEAARGFCSKKV------------------------------LAQIYTCLGCCAQRMG ------------------------------------------------------------ ------KPQTAL-----QHLKRALQVDFQCLSALSH------------------------ ---------------------------------------------------------AAA VYRELGEI----------DTELQALALLYEALEKKPP-AAA---SSS------------- --------PNIL----------------------------------IQTEL--------- ------------------------------------------------------------ -------LVHTPALTSLLRHRH-------------------------------------- -------------------------------PSEVKYLL--------------------- --------------AQRCLQG--------------------------------------- ------------------------------------------------------------ -----GRVAD----------AVEHY----------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ LDF--------------------------------------------------------- ------------------------------------------------------------ -----LALLQ-EGL---------------------------------------------- -------------------------------------------------------QQQ-- ------------------------------------------------------------ ---------------------------------------------V------P------- -----LDGSST-LPRIPEVFLEAASALEQAGRHQDA------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ITVCE------------------------------------------------------- ---------------------------------------------------------EVI RRTTDL-----IPRMLREE---------------------------ERLEQPECPSP--- ------------------------------------------------------------ ----------------------GAGLA-------------------------GELLSQK- ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------K------------------- ------------------------------------------------------------ -----------ESLC--------------CLAWRTA------------------------ ------------------------------------------------------------ ------------------------------------------------------GYLHQG WAWAKL--GESKEAVMQFSRCLSDLLRVQLRGPGTEPIENV------------------- --------PPE-VE---------------------------------------------- ------------------------------------------------------------ -------------------------------------------V---------------- -----------------------LQKI--------------------------------- --------------------------------------------RLLSLIGRGTQFLEL- ---------------------------------------------------------GRH KEALLDFQHGL------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------HISP------------------------ ----------------------------------------GDPAAASY------------ ---------------------------------------LVQALWKL------------- ----------------------------------------------------DRKQEAAA Q---------------------W------------------------QKLSQSS-----P G--------DQE----------GKGR----------P----------------------- ------------------LPLYLVSC---------------------------------- -----------------------------------------------------LEHAMFP HSETLAST----------------------------------------IQDYLETA---- ------------------------------------------------------------ -------AQDTS-S------------------------ >ENSLCOP00000019261 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------M-----------KRRR------------------------ --------------------------EEAPGP----------GQDTEREQERG------- ------CLRFWAAHSWALAERWT------------------------------------- -------------VRHVPFLPCPGPRA-----PAKFLVGLAVPT---------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------------------G--- -------------------------------------------LPVALPTLP-------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------LELTVLYNSLLFTLG- -ASDSAIEGQPDGIRQGLLR----------------------------------VLEACG -ACG---QDL--STEEL---------------WQKV------------------------ ------------------------------------------------------------ ---------LQEVT-VEELQAPLHRLGA-------------------------------- ------------------------------------------------------------ ---------------------------LQA------------------------------ ---------------------------AWWLAAGRLGSIAGL------------------ ---------------------------------------------------------FRL LST----------------------AEDT-GRGRCS---EGQ------------------ --NELLS-----LLKTWQVPAEG------------------------------------- -----------------------------------------------------VCLPL-V QSAEDLKEILC-------------------------------------------T----- ---------------AAAFLQGL--------QELEAGNF----------------PTALS LLQEAARGFCSKKV------------------------------VAQIYTCLGCCAQRMG ------------------------------------------------------------ ------KPQTAL-----QHLKRALQVDFQCLSALSH------------------------ ---------------------------------------------------------AAA VYHELGEI----------DTELQALALLCEALKKKPP-AAA---SSS------------- --------PNIL----------------------------------IQTEL--------- ------------------------------------------------------------ -------LVHTPTLTSLLRHRH-------------------------------------- -------------------------------PSEVKYLL--------------------- --------------AQRCLQG--------------------------------------- ------------------------------------------------------------ -----GRVAD----------AVEHY----------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ LDF--------------------------------------------------------- ------------------------------------------------------------ -----LALLQ-DGL---------------------------------------------- -------------------------------------------------------QQQ-- ------------------------------------------------------------ ---------------------------------------------V------P------- -----LDGSST-LPRIPEVFLEAASALEQAGRHQDA------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ITVCE------------------------------------------------------- ---------------------------------------------------------EVI RRTTDL-----IPRMLREE---------------------------ERLEQPECPSP--- ------------------------------------------------------------ ----------------------GAGLA-------------------------GELLSQK- ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------K------------------- ------------------------------------------------------------ -----------ESLC--------------CLAWRTA------------------------ ------------------------------------------------------------ ------------------------------------------------------GYLHQG WAWAKL--GESKEAITQFSRCLGDLLRVQLRGPGTEPIENV------------------- --------PPE-VE---------------------------------------------- ------------------------------------------------------------ -------------------------------------------V---------------- -----------------------LQKI--------------------------------- --------------------------------------------RLLSLIGRGTQFLEL- ---------------------------------------------------------GRH KEALLDFQHGL------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------HISP------------------------ ----------------------------------------GDPAAASY------------ ---------------------------------------LVQALWKL------------- ----------------------------------------------------DRKQEAAA Q---------------------W------------------------QKLSQSS-----P G--------EQE----------GKGR----------P----------------------- ------------------LPLYLVSC---------------------------------- -----------------------------------------------------LEHAMFP HSETLAST----------------------------------------IQDYLETA---- ------------------------------------------------------------ -------AQDTS-S------------------------ >ENSCPUP00000007781 MV--------------------P------------------------------------- ------------------------------------------------------------ ----------------------DSLAHQSRAAARRAPANQGKAGGERGKR---------- -----------------AGGYET------------------------------------- -----------------AAAM-----------KRRR------------------------ --------------------------GSPPEP--------------------G------- ------CLQAWAAENRALAERWRAAR---------------------------------- ------CSG-----------------------------------PG-------------- ------------------------GAVK-------------------------------- --------REVRQ---------------------------------------------QR GGFGELLLRM-------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------Q----------------------------------G--- -------------------------------------------LPAALPTLP-------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------LELTVLYNSMLFTMG- -ASDSAIKEAAEGIHQGLLR----------------------------------VLEACG -ACG---KDL--STEEL---------------WQKV------------------------ ------------------------------------------------------------ ---------LREVT-VEELQAPLHRLGA-------------------------------- ------------------------------------------------------------ ---------------------------LQA------------------------------ ---------------------------AWWLAASRLGSTAGL------------------ ---------------------------------------------------------FRL LSN----------------------AEDP-GRARCS---EGE------------------ --DELLS-----LLKAWRVPAEG------------------------------------- -----------------------------------------------------ASLPL-V QSTEDLKEILC-------------------------------------------T----- ---------------ATAFLQGL--------QELEAGNF----------------PAALS LLQEAAGGFCSKRV------------------------------LAQIYTCLGCCAQRMG ------------------------------------------------------------ ------KLQTAL-----QHLKRALQVDFQCLPALSH------------------------ ---------------------------------------------------------VAA VYQELGET----------EAELQTLALLYEALGKNPP-VAA---SSS------------- --------PHIL----------------------------------IRTEL--------- ------------------------------------------------------------ -------PVHTPILASLLRHRH-------------------------------------- -------------------------------PSEVKYLL--------------------- --------------ARRCLQD--------------------------------------- ------------------------------------------------------------ -----GRVAD----------AVEHY----------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ LDF--------------------------------------------------------- ------------------------------------------------------------ -----LSLLQ-EGL---------------------------------------------- -------------------------------------------------------QQQ-- ------------------------------------------------------------ ---------------------------------------------V------P------- -----LDGGSP-LPRIPEVFLEAASALEQAGRHQDA------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ITLCE------------------------------------------------------- ---------------------------------------------------------EVI SRTTDL-----IPRMLQVE---------------------------ERLQQPECPSP--- ------------------------------------------------------------ ----------------------GTG------------------------------PSQQ- ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------K------------------- ------------------------------------------------------------ -----------ESLC--------------CLAWRAA------------------------ ------------------------------------------------------------ ------------------------------------------------------GYLHQG WAWATL--GENKEAITQFSRCLSDLLRVQMDVSGAEPAENL------------------- --------LPE-VE---------------------------------------------- ------------------------------------------------------------ -------------------------------------------V---------------- -----------------------LQKI--------------------------------- --------------------------------------------RLLSLIGRGTQFLAL- ---------------------------------------------------------GRH KEALLDFQHGL------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------QISP------------------------ ----------------------------------------DDPAALPY------------ ---------------------------------------LVEALWKL------------- ----------------------------------------------------DRKPEAAA R---------------------W------------------------QKFSRSS-----P G-E----D--------------GQGR----------P----------------------- ------------------LPLFLASC---------------------------------- -----------------------------------------------------LQRAAFP RREELTRS----------------------------------------LGDYLGTL---- ------------------------------------------------------------ -------HGDPA-S------------------------ >ENSMUNP00000010894 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------P----------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------------QHKKDMELLEQ VQRRQAEKAGPAQLVVGLSVIT----------------------------------G--- -------------------------------------------LPATLPTLP-------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------LELTVLYNSLLFTMG- -ASDSAVEGQ-EGIRQGLLR----------------------------------VLEACG -ACG---QDL--SSEEL---------------WQKV------------------------ ------------------------------------------------------------ ---------LQEVT-VAELQAPLHRLGA-------------------------------- ------------------------------------------------------------ ---------------------------LQA------------------------------ ---------------------------AWWLSTDRLGSITGL------------------ ---------------------------------------------------------LRL LSN----------------------AEDL-GKAHWT---KVE------------------ --NELLS-----LLKAWRVPAEE------------------------------------- -----------------------------------------------------DSLCL-V QSTRDLKEILY-------------------------------------------T----- ---------------SAAFLQGL--------QEFEAGNF----------------PTARS LLQEAAGGFCSKKV------------------------------LAQIYTCLGCCAQRMG ------------------------------------------------------------ ------KPQTAL-----QYLKQALQVDFQCLPALSH------------------------ ---------------------------------------------------------VAA VYHELGET----------DAELQALALLYEALEKNPP-AAA---SSS------------- --------PYFL----------------------------------IRTEL--------- ------------------------------------------------------------ -------LVHTPVLASLLHHHH-------------------------------------- -------------------------------PSEVKYLL--------------------- --------------AQRCLQN--------------------------------------- ------------------------------------------------------------ -----GRVAD----------AVEHY----------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ LDF--------------------------------------------------------- ------------------------------------------------------------ -----LALLQ-EGL---------------------------------------------- -------------------------------------------------------QQQ-- ------------------------------------------------------------ ---------------------------------------------V------P------- -----LNGSSA-IPRIPEVFLEAASALEQAERYQDA------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ITVSE------------------------------------------------------- ---------------------------------------------------------EVI SRTTGL-----IPRVLLLE---------------------------ERPEQPECPSP--- ------------------------------------------------------------ ----------------------QAGLA-------------------------SGLLAQK- ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------K------------------- ------------------------------------------------------------ -----------ESLS--------------YLAWRAA------------------------ ------------------------------------------------------------ ------------------------------------------------------GYLHQG WVLGKL--SEVKEAVTQFSRCLEELLRVQLYGPGVEPTENL------------------- --------LPE-VE---------------------------------------------- ------------------------------------------------------------ -------------------------------------------V---------------- -----------------------LQKI--------------------------------- --------------------------------------------RLLALIGRGVQFLEL- ---------------------------------------------------------GKH KKALLDFQHGL------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------QVSP------------------------ ----------------------------------------GDPAAASY------------ ---------------------------------------LVQALWNL------------- ----------------------------------------------------DRKQEAAA Q---------------------W------------------------QKLSQRP-----S K-E----DGQQE----------GQGR----------P----------------------- ------------------VPLYLVSC---------------------------------- -----------------------------------------------------LKQAMFP HSDDLAKR----------------------------------------IQNYLGST---- ------------------------------------------------------------ -------TQDHP-S------------------------ >ENSGALP00000003124 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------M-----------KRLR------------------------ -------------------------CGTAPEP--------------------G------- ------CLQAWAAECEALAGRWRAAR-GSA------------------------------ ------YGGA-------------------------------------------------- -------------------------AAV-------------------------------- ----------ARQ---------------------------------------------LR GAFGELLLQM-------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------W----------------------------------G--- -------------------------------------------LPPALPMMP-------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------LELTVLYNSLLFVMG- -TSDCAIKGEAEGIRQGLLR----------------------------------VLEACG -TSG---QDL--STQEL---------------WQKV------------------------ ------------------------------------------------------------ ---------LQEVT-VEELQAPLHRLGA-------------------------------- ------------------------------------------------------------ ---------------------------LQA------------------------------ ---------------------------AWWLATSCLQNIIDL------------------ ---------------------------------------------------------FRL LSS----------------------AEDP-ERAPCR---AEK------------------ --NELLT-----LLKAWRTPAEE------------------------------------- -----------------------------------------------------ASVSL-V QSTEDLKETLC-------------------------------------------T----- ---------------AAAFLQGL--------QELEAGNL----------------STTLC LLQEAAGGFCSKRV------------------------------LAQIYVCLGCCAQRMG ------------------------------------------------------------ ------KPQTAL-----QHLKQALQVDFQCHPALSH------------------------ ---------------------------------------------------------TAA VYQELGET----------DAELQALYLLYEAVEKNPP-SAT---SSS------------- --------PYFL----------------------------------IRAEL--------- ------------------------------------------------------------ -------LVNTPILASLLRHHH-------------------------------------- -------------------------------PSEVKYLL--------------------- --------------AQRCLRD--------------------------------------- ------------------------------------------------------------ -----GRVAD----------AVEHY----------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ LDF--------------------------------------------------------- ------------------------------------------------------------ -----LSLLQ-EGL---------------------------------------------- -------------------------------------------------------QQQ-- ------------------------------------------------------------ ---------------------------------------------V------P------- -----LDGGSP-LPRIPEVFLEAASALEQDGRHQDS------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ LTVCD------------------------------------------------------- ---------------------------------------------------------EVI SRTTNL-----IPKIIQVE---------------------------EKLEQPECASL--- ------------------------------------------------------------ ----------------------ETGLA-------------------------GGLLSQK- ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------R------------------- ------------------------------------------------------------ -----------ESLC--------------CLTWRAA------------------------ ------------------------------------------------------------ ------------------------------------------------------AYLHQG WVWSKL--GKGKEAIMQFSRCLNDLLRFQPRGCGVEPAESL------------------- --------LPE-VK---------------------------------------------- ------------------------------------------------------------ -------------------------------------------V---------------- -----------------------LQKI--------------------------------- --------------------------------------------RLLSLIGRGMQFLEQ- ---------------------------------------------------------EKH KEALLDFQHGL------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------QISP------------------------ ----------------------------------------DDPAAASY------------ ---------------------------------------LVQVLWKL------------- ----------------------------------------------------NRKQEAAD Y---------------------W------------------------QKYLESP-----A G-E----DGQQE----------RQGR----------H----------------------- ------------------FPLYLDSC---------------------------------- -----------------------------------------------------LKQATFP QNESLARC----------------------------------------IQDYLRTT---- ------------------------------------------------------------ -------RQDSS-R------------------------ >ENSCJPP00005006287 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------M-----------KRLR------------------------ -------------------------RGAAPEP--------------------G------- ------CLQAWAAQCEALAGRWREAR-GSA------------------------------ ------CGGE-------------------------------------------------- ---------------------------V-------------------------------- ----------ARQ---------------------------------------------LR GAFGELLLRM-------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------Q----------------------------------G--- -------------------------------------------LPPALPTMP-------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------LELTVLYNSLLFVLG- -TSDCAIKGEAEGIRHGLLR----------------------------------VLEACG -TCG---QDL--STEEL---------------WQKV------------------------ ------------------------------------------------------------ ---------LQEVT-VEELQSPLHRLAA-------------------------------- ------------------------------------------------------------ ---------------------------LQA------------------------------ ---------------------------AWWLAASCLQSITDL------------------ ---------------------------------------------------------FRL LSR----------------------SEDP-GRTPCS---GEK------------------ --NELLA-----LLKAWRAPAEE------------------------------------- -----------------------------------------------------ASISL-V QSTEELKETLC-------------------------------------------T----- ---------------AAAFLQGL--------QELEAGNL----------------STTLC LLQEAAGGFCSKRV------------------------------LALIYVCLGCCAQRMC ------------------------------------------------------------ ------KPQTAL-----QHLKRALQVDFQCHSALLH------------------------ ---------------------------------------------------------TAA VYQELGET----------DAELQALSLLYEALERNPP-SAT---SSC------------- --------PYFL----------------------------------IRVEL--------- ------------------------------------------------------------ -------LVNAPILVSLLRHRQ-------------------------------------- -------------------------------PSEVKYLL--------------------- --------------AQRCLQD--------------------------------------- ------------------------------------------------------------ -----GRVAD----------AVEHY----------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ LDF--------------------------------------------------------- ------------------------------------------------------------ -----LALLQ-EGL---------------------------------------------- -------------------------------------------------------QQQ-- ------------------------------------------------------------ ---------------------------------------------V------P------- -----LDGDSL-LPRIPEVFLEAASALEQGGRHQDS------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ LAVCD------------------------------------------------------- ---------------------------------------------------------EVI SRTTNL-----IPQIVQIE---------------------------EKLERPECASL--- ------------------------------------------------------------ ----------------------EAGLA-------------------------GGLPSQK- ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------R------------------- ------------------------------------------------------------ -----------ESLC--------------CLMWRAA------------------------ ------------------------------------------------------------ ------------------------------------------------------AYLHQG WVWTKL--GKGKEALMQFSRCLNELLRFQPCGRGVEPAESL------------------- --------LPE-VK---------------------------------------------- ------------------------------------------------------------ -------------------------------------------V---------------- -----------------------LQKI--------------------------------- --------------------------------------------RLLSLIGRGMQFLEQ- ---------------------------------------------------------ERH KEALLDFQHGL------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------QISP------------------------ ----------------------------------------DDPTAAFY------------ ---------------------------------------LVQVLWKL------------- ----------------------------------------------------NRKQEASD Y---------------------W------------------------QKYSESP-----A V-E----DRQQE----------RP------------------------------------ ------------------FPLYLDSC---------------------------------- -----------------------------------------------------LKQAALP QDGSLVRC----------------------------------------IQDYLRTT---- ------------------------------------------------------------ -------RQDSA-V------------------------ >ENSACAP00000023434 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------M-----------AASG------------------------ --------------------------ES-------------------------------- ------CVSLWRGENDELVRRWRRVT-RS------------------------------- ------------------------------------------PGPG-------------- ------------------------CSVA-------------------------------- --------ETAQQ---------------------------------------------CR LAFTKLLQKI-------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------Q----------------------------------G--- -------------------------------------------LPAVLPALP-------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------LELTILYNSLLFDIH- -LSSSSDEELLAGIDYGLTR----------------------------------VLEA-- -----------------YSVPDHSISPEG--RWKKL------------------------ ------------------------------------------------------------ ---------LQEGA-SKELQAALHQLAA-------------------------------- ------------------------------------------------------------ ---------------------------LQA------------------------------ ---------------------------ALWLVTNRLEAVEDL------------------ ---------------------------------------------------------FRI LTG----------------------AKDL-EPSPCS---SHQ------------------ --NELLS-----LLQTWRPQDSE------------------------------------- -----------------------------------------------------EYDPLVA QSVRDLKEILW-------------------------------------------T----- ---------------SAAFLQGI--------QQLEAGNS----------------TAALA FFKAAAAGLSSKRV------------------------------LAQTFTLMGCCNLRLG ------------------------------------------------------------ ------KPQVAL-----QHLRRALQVDFTFLPALHQ------------------------ ---------------------------------------------------------AAL LYRQLELL----------EAELESLALLYQALDGPMEVTSE---SVD------------- --------PHFL----------------------------------IRIER--------- ------------------------------------------------------------ -------LIRSAQRTPFFAQKC-------------------------------------- -------------------------------PAGVKYLL--------------------- --------------AQRCLQA--------------------------------------- ------------------------------------------------------------ -----GRAGE----------AAEHY----------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ LDL--------------------------------------------------------- ------------------------------------------------------------ -----LAMLQ-EG----------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------PL------ -PQVCQSKMPV-LPRIPEVFLEAASALEELAKHEDA------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ LVVCE------------------------------------------------------- ---------------------------------------------------------EVV TRTSLL-----VPKKLRLG----------------------------------------- ------------------------------------------------------------ ------------------------------------PGLNGDEDVLWAKSP-GTVQEQR- ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------R------------------- ------------------------------------------------------------ -----------ESLC--------------CILWRAA------------------------ ------------------------------------------------------------ ------------------------------------------------------AHVIQG WACGRL--GEAKEAISHFSRSLDDLLRIH-----------FVSADGACNSSAEEEWEKL- -------RLSE-MK---------------------------------------------- ------------------------------------------------------------ -------------------------------------------I---------------- -----------------------LPQI--------------------------------- --------------------------------------------RQLALTGRGAQFLEL- ---------------------------------------------------------GRD KEALMDFQHSL------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------HVCP------------------------ ----------------------------------------DSPSANWY------------ ---------------------------------------LVHTLWKL------------- ----------------------------------------------------GRRKEAAA H---------------------W------------------------QKFVPKS-----A P-M----DEKAE----------G-------------S----------------------- ------------------FPLYLQSC---------------------------------- -----------------------------------------------------ARQMKFP QAESLIKN----------------------------------------MEGFLGGK---- ------------------------------------------------------------ -------SLE---P------------------------ >ENSSMRP00000026099 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------M-----------ARSG------------------------ --------------------------GSS-----------------------N------- ------CLELWREENDGLARRWRTAA-SS------------------------------- ------------------------------------------PGSG-------------- ------------------------CSVT-------------------------------- --------QTAQQ---------------------------------------------CQ VAFTNLLQKI-------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------Q----------------------------------G--- -------------------------------------------LPAALPALP-------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------LELTILYNSLLFSIH- -LSSNSGSTQLPAINHGLIR----------------------------------VLEACA -GDS---QGL--GSEDC---------------WQRV------------------------ ------------------------------------------------------------ ---------LQGGI-PEELQPLLHQLAA-------------------------------- ------------------------------------------------------------ ---------------------------LQV------------------------------ ---------------------------ALCLASNRLGLAEEL------------------ ---------------------------------------------------------LRL LNG----------------------TKGLPDPSPSS---HCS------------------ --TQLLL-----LLQMWHPAELG------------------------------------- -----------------------------------------------------AGDPLVV QSMRDLKGVLW-------------------------------------------T----- ---------------SAAFLQGV--------QALNDGHL----------------SVAVS LLQTAATGLCSKRV------------------------------LAQIFTLIGCCSLKME ------------------------------------------------------------ ------KPQTAL-----QYLKQAXQVDATFLPALYQ------------------------ ---------------------------------------------------------AAL LYRQLGLL----------EAELEAVTLLCQALDGAVQVTTT---SMR------------- --------PAFL----------------------------------IHTE---------- ------------------------------------------------------------ -------LLTSAQLAGFFVQNS-------------------------------------- -------------------------------PSEVKYLL--------------------- --------------AQRSLQA--------------------------------------- ------------------------------------------------------------ -----GRASE----------AVEHY----------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ LDL--------------------------------------------------------- ------------------------------------------------------------ -----LALLQ-EGF---------------------------------------------- -------------------------------------------------------LHQW- ------------------------------------------------------------ -------------------------------------------GSL------P------- ------------LPRIPEVFLEAASALEMLARHQDA------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ LTVCE------------------------------------------------------- ---------------------------------------------------------EVV AHTNAL-----IP----------------------------------------------- ------------------------------------------------------------ --------------------------------------------------------EQL- ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------RI------------------ -ERG------------------AQRDPQATGFA---------VTESPAS----------L TKR------EEESLC--------------CVLWQAA------------------------ ------------------------------------------------------------ ------------------------------------------------------AYLIQG SAWAGL--GKAKEAITHFSRCLNDLLKVH-----------FVNRGGNTDDHAEQ----L- -------GLPE-LK---------------------------------------------- ------------------------------------------------------------ -------------------------------------------A---------------- -----------------------FPKI--------------------------------- --------------------------------------------RQLALIGRGVQFLDL- ---------------------------------------------------------GQG KEALMDFQHSL------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------HACP------------------------ ----------------------------------------DSPTANLY------------ ---------------------------------------LLYTLWKL------------- ----------------------------------------------------DRRQEAAA Q---------------------W------------------------QNLRLNP-----A L-L----EEEAD----------R-------------S----------------------- ------------------FPLYLLSC---------------------------------- -----------------------------------------------------XKQMKFP HRDSLTRS----------------------------------------METYLG------ ------------------------------------------------------------ ---------E---H------------------------ >ENSXETP00000016919 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------M--------------------------------------- --------------------------------------------------AGD------- ------CLTLWLEENNVIVSQWQGST-S-------------------------------- ------------------------------------------------------------ ------------------------CANT-------------------------------- --------PTDKQK---------LQ--------------------------------LCH ADLYRLLQKI-------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------Q----------------------------------G--- -------------------------------------------LPASPRSLP-------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------LEMSVLFNAVICHIS- -ATGRIHGEHNNHIAEALVR----------------------------------VLAVGS -PGV---TEQ--SSAEL---------------WQRV------------------------ ------------------------------------------------------------ ---------LRGGY-APDMAAPLHRVAG-------------------------------- ------------------------------------------------------------ ---------------------------LQG------------------------------ ---------------------------ALWLAEEKLQEVHDL------------------ ---------------------------------------------------------ISS LLH----------------------PEDP-ACSTHI---RAE------------------ --EKLLA-----VLRAWRVPSES------------------------------------- -----------------------------------------------------GERALVV QPVQQLRDVLY-------------------------------------------T----- ---------------SAAFLQGI--------RAMEASQL----------------PSAID LLREAAESLCSSRV------------------------------LAQMYTCLGFCFQKLE ------------------------------------------------------------ ------KPQTAL-----QYWKQALQLDFHCLAALHH------------------------ ---------------------------------------------------------SAA LYRAMGNV----------EAELEALSLLYKALLSPQP-EAA---SSS------------- ------TQACFL----------------------------------IGTEL--------- ------------------------------------------------------------ -------IVKAPSLTCAVRSPS-------------------------------------- -------------------------------PWKVKYLT--------------------- --------------ARSCLAS--------------------------------------- ------------------------------------------------------------ -----KRGEE----------AAEHY----------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ LDL--------------------------------------------------------- ------------------------------------------------------------ -----LALLQ-DEA---------------------------------------------- -------------------------------------------------------HQE-- ------------------------------------------------------------ ---------------------------------------------D------L------- -----LPNPDP-APRIPEVFLEAAASLVLEKRWQDA------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ MTVCE------------------------------------------------------- ---------------------------------------------------------EVL GRTAEL-----IPGSLSVD---------------------------RTQGSP-------- ------------------------------------------------------------ -----------------------AGIA--------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------EQLN--------------CILWASA------------------------ ------------------------------------------------------------ ------------------------------------------------------AHLHQG LSQGLL--GDHKEAVTEYTKCINLLVKVQFTNTGKRCLSFLCPGAG---EEMETDWH--- --------STE-EA---------------------------------------------- ------------------------------------------------------------ -------------------------------------------M---------------- -----------------------LCVL--------------------------------- --------------------------------------------KAAAFLGRGRQFLAL- ---------------------------------------------------------GKQ KESLVNVQLGL------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------QVSP------------------------ ----------------------------------------AFPGAALT------------ ---------------------------------------RVGLLRTL------------- ----------------------------------------------------GRRTEAAS Y---------------------L------------------------QRYRGER-----E S-L----AEQWG----------ALKR----------D----------------------- ------------------LPLYLDPH---------------------------------- -----------------------------------------------------IGDP-FP AHDSLTGE----------------------------------------LDESAEEM---- ------------------------------------------------------------ -------ESEAA-V------------------------ >ENSSFOP00015028772 MYY--------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------QTSKFVKK------------------------------- ---------SNQMY----PRM-----------S--------------------------- -------------------------------------------------FGS-------- ------CWDTWVKENDIFVKKWKCAE-RN------------------------------- ------------------------------------------------------------ -----------------------RKGEQQ------------------------------- --------GARRE---------------------------------------------YY GEMCNLLRRV-------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------Q----------------------------------G--- -------------------------------------------VLPVTGSVR-------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------LELAVLYNTSLFSLS- -LSDREETRR--LVVEGLTR----------------------------------VLEAFG -CEP---PGS--DLLVL---------------WRAV------------------------ ------------------------------------------------------------ ---------LQALQ-SSECLSAIHQLLC-------------------------------- ------------------------------------------------------------ ---------------------------VQW------------------------------ ---------------------------ALWLTTGQLDMIQEV------------------ ---------------------------------------------------------LPS HSQ----------------------VTIR----------SPS------------------ --GHLPP-----LIQDLVFPSEENSSL--------------------------------- ---------------------------------------------------------LVV ISPRELKELTH-------------------------------------------I----- ---------------CTLIAKGV--------RKLREGEE----------------AEALQ AFQDAALLPAPRKL------------------------------LAQIHTLSGMCLAKLG ------------------------------------------------------------ ------RPQSSL-----QCYRNAMEVDFGCRSALYQ------------------------ ---------------------------------------------------------SCV VYQRLGNT----------QAEMEALRLLHSVVVSPTS--ES---TSN------------- --------MIPL----------------------------------ISHVD--------- ------------------------------------------------------------ -------LLRSQALEGIFSVPA-------------------------------------- -------------------------------PVGIQHML--------------------- --------------AQRCLHS--------------------------------------- ------------------------------------------------------------ -----GRITE----------AADHY----------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ LDL--------------------------------------------------------- ------------------------------------------------------------ -----LASFQ-SDT---------------------------------------------- -------------------------------------------------------KIL-- ------------------------------------------------------------ ---------------------------------------------M------I------- -----ADGHST-LPRIPDIYLEAAVTMLKAKRFWDS------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ IAVCE------------------------------------------------------- ---------------------------------------------------------EVL KKTVEL-----IPGRLVLN---------------------------LSI----------- ------------------------------------------------------------ ---------------------------------------------------KEGMETESV A-------------------PSIP------------------------------------ ------------------------------------------GTEDFAGRNGEA------ ----------------------------------------R------------------- ------------------------------------------------------------ -----------EQLK--------------YVLWAGT------------------------ ------------------------------------------------------------ ------------------------------------------------------ALLIQG QAYSWL--KENKEAITSLTRSINLLVKVHFL----------------------------- ------------HK---------------D------------------------------ -----------WKYGDLG--DKEAAG---------------------------------- ----------------------SDV-----------------QA---------------- -----------------------LQRL--------------------------------- --------------------------------------------KGLALASRGVSFMDR- ---------------------------------------------------------GQD SVALQDFQLSL------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------QASP------------------------ ----------------------------------------GFESVQRW------------ ---------------------------------------LVHALRKL------------- ----------------------------------------------------KREDEALS F---------------------S------------------------KSMRKTT-----S E-P-------EA-----------------------PSY---------------------- ----PTGILP--------VLLHLESY---------------------------------- -----------------------------------------------------LEDRMPV DSELLK-------------------------SRHV------------WSRE--------- ------------------------------------------------------------ ----------VT-P------------------------ >ENSPKIP00000035397 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------M-----------S--------------------------- -------------------------------------------------PSD-------- ------CLVIWTEQNNDIVKKWKCAE-RK------------------------------- ------------------------------------------------------------ -----------------------HKANGQ------------------------------- --------DVRCQ---------------------------------------------YY NELCSLLHII-------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------Q----------------------------------G--- -------------------------------------------ALCDAASLE-------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------LELTVLYNTLLFSLS- -LSKFCEAGN--LLTQGIIR----------------------------------VLEAFG -CQP---PSS--DLLVL---------------WREF------------------------ ------------------------------------------------------------ ---------LEKFQ-SPRLLPSAHALLC-------------------------------- ------------------------------------------------------------ ---------------------------VQW------------------------------ ---------------------------TLWLSTQQLDSIQKL------------------ ---------------------------------------------------------LLP DSQ----------------------DGIM----------S-------------------- ----LPP-----EIENVQVSPERNPPL--------------------------------- ---------------------------------------------------------LLI MPPRALKELAH-------------------------------------------I----- ---------------CTVVTQGV--------GKMKEGKD----------------SEAVQ ILQDASMLPSPTSL------------------------------LAEIHMRTGICLARLG ------------------------------------------------------------ ------RPQSSL-----QCYRRALEMGASSRTVLYQ------------------------ ---------------------------------------------------------CSL LHRQLENC----------PAEIEMLRLLCTAAHSPVS-CDP---SST------------- --------WVPL----------------------------------LTPDT--------- ------------------------------------------------------------ -------LLGDPACDSVFAMPS-------------------------------------- -------------------------------LLEMQHTL--------------------- --------------AHRCLHC--------------------------------------- ------------------------------------------------------------ -----GRFSE----------AAENY----------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ LDL--------------------------------------------------------- ------------------------------------------------------------ -----LATLQ-CDL---------------------------------------------- -------------------------------------------------------KQL-- ------------------------------------------------------------ ---------------------------------------------V------N------- -----TDVNSR-LPRVPDIYLEAAVTLLKAERYWDS------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ IAICE------------------------------------------------------- ---------------------------------------------------------EVI MKTAEL-----IPDRLVLE---------------------------MPL----------- ------------------------------------------------------------ ---------------------------------------------------RDELDDGSL V-------------------PFSP------------------------------------ ------------------------------------------EMRGLFAKSGKA------ ----------------------------------------E------------------- ------------------------------------------------------------ -----------ERLN--------------YVLWAGT------------------------ ------------------------------------------------------------ ------------------------------------------------------AFLIEG QAYGWL--KESKGEITALTRSINLLVKVRLK----------------------------- ------------NE---------------E------------------------------ -----------WQHRDPG--DN--AA---------------------------------- ----------------------SKV-----------------AA---------------- -----------------------LRKL--------------------------------- --------------------------------------------KALALASRGVGFMDR- ---------------------------------------------------------KQE GAALQDFQLSL------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------QASP------------------------ ----------------------------------------GTEVVELW------------ ---------------------------------------LTRVLWNM------------- ----------------------------------------------------GREEEATT F---------------------W------------------------KSTRRTS-----Q V-P-------E------------------------------------------------- -------LVPNCSRN-AAVFLHLQSY---------------------------------- -----------------------------------------------------LQEKMPA DSESLKKMK---------------------LSR--------------------------- ------------------------------------------------------------ -------------------------------------- >ENSLOCP00000007998 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------M-----------D--------------------------- -------------------------------------------------RENCLGR---- ----RGCLDFWTKENNSIITKWKSVQ-RV------------------------------- ------------------------------------------------------------ -----------------------QKGNHQ------------------------------- -------KDLLKQ---------------------------------------------CY SEIGKLLQKI-------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------Q----------------------------------G--- -------------------------------------------LPSVAATLS-------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------LELTVLYNTLLFSFG- -LSDHGGAGRGELLTLGLVR----------------------------------ALEALD -SEP---QSS--DPLDL---------------WRAV------------------------ ------------------------------------------------------------ ---------LQISG-SQEWIVFFHQLAC-------------------------------- ------------------------------------------------------------ ---------------------------LQW------------------------------ ---------------------------AEWLSAGQLEKIRELA----------------- --------------------------------------------------------VLLA DSR--------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ --------VSHCRMAERTVMFYIQQILCPVDSISRPEYLQEKQIQKNIIISKYLI----- ---------------SYVFLVGA--------EMMEAGEV----------------SAALL NFQEAAALPCPRSV------------------------------LAQVHTLMGLCLRQLG ------------------------------------------------------------ ------RPQSAL-----QCYRKALEIDFGCLSALYQ------------------------ ---------------------------------------------------------SSL VFRQLAVA----------QAEIEALRLLHSAVK------ES---CCN------------- --------WIHL----------------------------------ITHES--------- ------------------------------------------------------------ -------LLCSPSLISTFKTPA-------------------------------------- -------------------------------VLGVKHSL--------------------- --------------AQSNLRY--------------------------------------- ------------------------------------------------------------ -----GRISE----------AVEQY----------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ LDL--------------------------------------------------------- ------------------------------------------------------------ -----LTSFH-ND----------------------------------------------- -------------------------------------------------------EQL-- ------------------------------------------------------------ ---------------------------------------------V------T------- -----TDSSPA-LPRIPEIYLEAAVSLLKAKRYWDV------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ VAVCE------------------------------------------------------- ---------------------------------------------------------EVV AKTVDL-----IPQRLTLD----------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------------HTEGK------ ----------------------------------------K------------------- ------------------------------------------------------------ -----------ESLN--------------CALWAAT------------------------ ------------------------------------------------------------ ------------------------------------------------------AFFFQG QAFTWL--KESKESISNYTRCINIVIKVPVE----------------------------- ------------HT---------------G------------------------------ -----------WLRGGPDLCEE--TL---------------------------------- ----------------------TSI-----------------MA---------------- -----------------------LRRL--------------------------------- --------------------------------------------KALAFAGRGVSFMAR- ---------------------------------------------------------QQG KEALLNFQLSL------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------QATP------------------------ ----------------------------------------GCEETELW------------ ---------------------------------------LTEALWSL------------- ----------------------------------------------------GRREEAVA F---------------------WS--------------------KHQSSTREETV---EE V-P-------Q------------------------------------------------- ----------------RALPLYLMSS---------------------------------- -----------------------------------------------------VGEMETV DAEEMRRR----------------------------------------MRE--------- ------------------------------------------------------------ ----------CS-S------------------------ >ENSAMXP00005027307 MV---------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------DM-----------P--------------------------- -------------------------------------------------VTAS------- ------LFNSWAEENNNIIRKWKEYE-KC------------------------------- ------------------------------------------------------------ -----------------------HQPQR-------------------------------- --------DTVKQ---------------------------------------------CY TELIKLQQKI-------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------Q----------------------------------G--- -------------------------------------------LPATAELLK-------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------LDLTVSYNTLLFSLS- -HSKPEEIRR--SVTDSLIR----------------------------------VLEVFE -AEV---PST--DPVTL---------------WQVV------------------------ ------------------------------------------------------------ ---------SKNVG-GAEYQAWIHPLLL-------------------------------- ------------------------------------------------------------ ---------------------------IQW------------------------------ ---------------------------VICLSECQFEEILHL------------------ ---------------------------------------------------------LQQ IKP----------------------QNKI----------TSS------------------ --GDLLA-----EIRNLTFSIQEDASL--------------------------------- ---------------------------------------------------------LVA IAAKDLKDLLH-------------------------------------------I----- ---------------CTFISKGV--------ELMNKENY----------------TESLL AFQEAATLSSPRTL------------------------------LAHVHTLTGLSFTKLG ------------------------------------------------------------ ------RLQSAL-----HCNRKALEVDFSCQRALYQ------------------------ ---------------------------------------------------------SSL VYKQLGNS----------QAEIEALNLLHSAALLNNE-KDP---SNT------------- --------PAPL----------------------------------ISPEM--------- ------------------------------------------------------------ -------LLGKEQMAFISQKPS-------------------------------------- -------------------------------PVSILHTL--------------------- --------------AHRCVLN--------------------------------------- ------------------------------------------------------------ -----DRNSE----------GAEYY----------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ LDL--------------------------------------------------------- ------------------------------------------------------------ -----LASLQ-------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------PGSRQ--------HI------P------- -----TSNDPP-FPRIPVIYLEAAFAMLKARRSWDT------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ LAICD------------------------------------------------------- ---------------------------------------------------------EVI TETLDL-----IPERMQLH---------------------------PPI----------- ------------------------------------------------------------ ---------------------------------------------------SQQQQSVGH ID------L---------------SL---------------------------------- -------------------------------------------------ESETV------ ----------------------------------------E------------------- ------------------------------------------------------------ -----------EKLD--------------CVLWCGA------------------------ ------------------------------------------------------------ ------------------------------------------------------AYFLQG HAHLQL--KDTKEALVTFTRAINQLVKVFIK----------------------------- ------------EK---------------------------------------------- ---------------------------------------------------FST------ ----------VNSAAESGDF-YSKV-----------------AT---------------- -----------------------LDAL--------------------------------- --------------------------------------------KGRTLAGRGVCFVER- ---------------------------------------------------------GQL KEALRDFQLSC------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------QASP------------------------ ----------------------------------------GCRNTEMW------------ ---------------------------------------LVEILWRL------------- ----------------------------------------------------NRKEEAAA L---------------------W------------------------KHNQEST-----D S-S-------TL-----------------------VD----------------------- ------------------MPLHLQTR---------------------------------- -----------------------------------------------------EEDLTHI DHSSLNKN----------------------------------------MEEFIQSC---- ------------------------------------------------------------ ---------SVK-TDN--------------------NR >ENSPNAP00000025542 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------M-----------S--------------------------- -------------------------------------------------VTPC------- ------LVDRWTEENNNIVRKWKEYE-NR------------------------------- ------------------------------------------------------------ -----------------------RQPLQ-------------------------------- --------DVRKH---------------------------------------------CY AEFLKLWQKI-------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------Q----------------------------------G--- -------------------------------------------LPATTEQLQ-------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------LEITASYNTLILSLS- -YSKPQDTQH--HLTNSLVR----------------------------------ALEAVG -AQV---SKT--DLGTL---------------LQAV------------------------ ------------------------------------------------------------ ---------LKTFG-GTVYQPCIHKLLL-------------------------------- ------------------------------------------------------------ ---------------------------IQW------------------------------ ---------------------------AIWLSECQFDGILHL------------------ ---------------------------------------------------------LQQ INP----------------------KNKI----------TPS------------------ --GDLLT-----EIRNLTFSIQEDISL--------------------------------- ---------------------------------------------------------LVA MAAKDLKDLLH-------------------------------------------I----- ---------------CTFVSKGL--------EQMRKENY----------------TEALL AIQEAATLSSPRAL------------------------------LAHIHTLTGLCFTKLG ------------------------------------------------------------ ------RPQSAL-----QCYRKALEVDFSCQRALYQ------------------------ ---------------------------------------------------------SSL VYRQSGNS----------QAEIEALHLLHSAVLLHTE-RDS---SST------------- --------PAAL----------------------------------ISPDM--------- ------------------------------------------------------------ -------LLGGEQMAFISQVPS-------------------------------------- -------------------------------PVLILHTL--------------------- --------------AHRCLLN--------------------------------------- ------------------------------------------------------------ -----DRNSE----------SAEFY----------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ VDL--------------------------------------------------------- ------------------------------------------------------------ -----LATLQ-S------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------PDSRP--------HG------P------- -----TIDALP-FPRIPVVYLEAAFAVLKAKRFWDS------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ IAICD------------------------------------------------------- ---------------------------------------------------------EVI AKTVDL-----VPER--------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -------------------------LLL-------------------------------- --------------------------------EPHHRSAGPTELAAVGVESEAV------ ----------------------------------------E------------------- ------------------------------------------------------------ -----------EKLD--------------CVLWSGA------------------------ ------------------------------------------------------------ ------------------------------------------------------AYFLQG HAYLQL--KDTKEALTIFTRAINQLVKVCVK----------------------------- ------------QK---------------C------------------------------ -----------WTVSNLG--QTEDSD------------------------N--------- -----------------------KV-----------------AT---------------- -----------------------LEAL--------------------------------- --------------------------------------------KGQTLAGRGVCFIER- ---------------------------------------------------------GQL KEALRDFQLSL------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------QAS------------------------- ----------------------------------------GCRNTEMW------------ ---------------------------------------LVETLWRL------------- ----------------------------------------------------DRKKEAAA M---------------------W------------------------HQSYNST-----D S-P-------TP-----------------------VE----------------------- ------------------LPLYLQTW---------------------------------- -----------------------------------------------------QEDATNL DHSNLNEK----------------------------------------MEKFIHSCGD-- ------------------------------------------------------------ -----ITMT----------------------------- >ENSEEEP00000047492 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------M-----------S--------------------------- -------------------------------------------------VTSC------- ------LAERWIEESNTIIKKWKENE-KL------------------------------- ------------------------------------------------------------ -----------------------RGQLQ-------------------------------- --------DIRKH---------------------------------------------CY AQCLKLHQKI-------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------Q----------------------------------G--- -------------------------------------------VPAVRQQVE-------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------LEFAVSYNTLLFSLT- -NSKPNEAND--RLTCCLIR----------------------------------ALEAVG -FPV---HCS--DQVTL---------------WQTV------------------------ ------------------------------------------------------------ ---------LKTFN-GKEHQTCIHKLLL-------------------------------- ------------------------------------------------------------ ---------------------------IQW------------------------------ ---------------------------AIWLSQCQFEGILQL------------------ ---------------------------------------------------------LQM INP------------------------KI----------TPS------------------ --GDLLA-----EIRNLTFSVKDDTSL--------------------------------- ---------------------------------------------------------LVA MAAEDLKDLLH-------------------------------------------I----- ---------------CTFISKGL--------EKMKTGNY----------------PEALQ DFQEAGTLSSPRAL------------------------------LAHVHTLMGLCYAKLG ------------------------------------------------------------ ------RPQSAL-----QCYRLALEVDFSCQRALYQ------------------------ ---------------------------------------------------------SAL VYKQLGNS----------HAEIEALRLLHS--------RNS---LSE------------- --------PVPL----------------------------------ISPDM--------- ------------------------------------------------------------ -------LLGSEQMAFISQIPS-------------------------------------- -------------------------------PVHILHIL--------------------- --------------GHTCVLN--------------------------------------- ------------------------------------------------------------ -----DRNSE----------GAECY----------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ LDL--------------------------------------------------------- ------------------------------------------------------------ -----LASLQ-SHS---------------------------------------------- --------------------------------------------------------TLHV K----------------------------------------------------------- -----------------------------HG----------------------------- ---------LP-FPRIPMIYLEAAFAMLKAKRFWDG------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ LAICE------------------------------------------------------- ---------------------------------------------------------EVI AKTADL-----IPERLFLE---------------------------PPMVTHQLTAP--- ------------------------------------------------------------ ---------------------------------IELSARSLEPD------PT-------- ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------K------------------- ------------------------------------------------------------ -----------ETLD--------------RVLWSGS------------------------ ------------------------------------------------------------ ------------------------------------------------------AYFLQG WAYLQL--KDTKAALTNFTRAINQLVKVCFK----------------------------- ------------QK---------------SKP---------------------------- --FFILFDQMVM------------------------------------------------ ------------------------------------------------------------ -----------------------LETL--------------------------------- --------------------------------------------KGQALTGRGLCFVER- ---------------------------------------------------------GQL MGALRDFQLSL------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------QTSP------------------------ ----------------------------------------GCSNTEMW------------ ---------------------------------------LVEILWRL------------- ----------------------------------------------------DRKEEAAA M---------------------W------------------------RQIKKCT-----D S-P-------TS-----------------------VD----------------------- ------------------LPLYLQAW---------------------------------- -----------------------------------------------------QEVAKYH GHSNLHKK----------------------------------------MEAFIHSCG--- ------------------------------------------------------------ ------TTA----------------------------- >ENSIPUP00000011600 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------M-----------P--------------------------- ---------------------------------------------------SN------- ------LVDRWAEENNNVAKKWKDYE-TR------------------------------- ------------------------------------------------------------ -----------------------RKSLQ-------------------------------- --------DIRKH---------------------------------------------CY TECLKLQQKV-------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------Q----------------------------------G--- -------------------------------------------VPAQIGHLK-------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------LEITVTYNTLLFSLS- -CGTPNETKD--CITNILIR----------------------------------ALEAVR -KQV---PTY--DLVPL---------------WEVV------------------------ ------------------------------------------------------------ ---------LKTFG-GTVHEAWIHKLLL-------------------------------- ------------------------------------------------------------ ---------------------------IQW------------------------------ ---------------------------AVWLSECYYEGILHL------------------ ---------------------------------------------------------LLQ VNH----------------------RKPN----------TPS------------------ --GDLLA-----ETRNLSFSIEDDTSL--------------------------------- ---------------------------------------------------------LDA LATKDLKELLH-------------------------------------------V----- ---------------CTFISNGV--------EQMMKEKC----------------TEALV TLQEASTQPSPRAL------------------------------LAHVHMLTGFCYSKLE ------------------------------------------------------------ ------QPQSAL-----QCYRKALEVDFNCHRALYQ------------------------ ---------------------------------------------------------SSL VYRQLGNT----------NAEIEALHLLHSAIMLRAE-SDP---SST------------- --------SVPL----------------------------------ISPDI--------- ------------------------------------------------------------ -------LLGSKQIDFICQIPS-------------------------------------- -------------------------------PLHILHTL--------------------- --------------GHRCVLS--------------------------------------- ------------------------------------------------------------ -----DRTSE----------GAEYY----------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ LDL--------------------------------------------------------- ------------------------------------------------------------ -----LASLQ-SDS---------------------------------------------- -------------------------------------------------------KQMPV D----------------------------------------------------------- -----------------------------DG----------------------------- ---------FS-FPRIPVIYLEAAFALLKAKRVWDA------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ LAVCD------------------------------------------------------- ---------------------------------------------------------EVI AKTVDL-----IPERLSIT---------------------------P------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------------STAVS----- ---------------RELI---------PLTL---EVDAPE------------------- ------------------------------------------------------------ -----------EKLE--------------CVLWSGA------------------------ ------------------------------------------------------------ ------------------------------------------------------AYFLQG QAHLQL--KDTKEALSNFTRAINQLVKVCIK----------------------------- ------------HK---------------VK----------------------------- -------------------------DPGA-------E-----RGAVAHTVMF-------- ------------------------------------------------------------ -----------------------LEAL--------------------------------- --------------------------------------------KGKVLAVRAVCFVER- ---------------------------------------------------------GQL NEALRDFQLSL------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------QATP------------------------ ----------------------------------------GCRNTEMW------------ ---------------------------------------LVEMMWRL------------- ----------------------------------------------------ERKQEAAA M---------------------W------------------------TQILNST-----Q T-S-------TP-----------------------VD----------------------- ------------------LPLYLQTW---------------------------------- -----------------------------------------------------HEDPTSF DLSNLKRK----------------------------------------MEEFIQNS---- ------------------------------------------------------------ ---------FVT-A------------------------ >ENSDARP00000038408 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------M-----------S--------------------------- -------------------------------------------------VIPC------- ------LADRWSEENNNIILAWKQNE-RS------------------------------- ------------------------------------------------------------ -----------------------LQPNQ-------------------------------- --------DVRKR---------------------------------------------CY SESLKLLQKT-------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------Q----------------------------------G--- -------------------------------------------LPAATERLK-------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------LELTVSYNTCLFALD- -FSNPSEMEE--SLTRSLFR----------------------------------ALEAAD -CPV---SST--EPVKL---------------WEDA------------------------ ------------------------------------------------------------ ---------LRTFG-CSVYLPYVHKLLL-------------------------------- ------------------------------------------------------------ ---------------------------LQW------------------------------ ---------------------------MLWLMQGQLERVLTL------------------ ---------------------------------------------------------LTQ IDS----------------------KREC----------SAP------------------ --VNLQT-----ETRNLPLRLEEDTSL--------------------------------- ---------------------------------------------------------MVA MAAKDLKELLH-------------------------------------------I----- ---------------CTVICQGV--------EQMKTEKY----------------SEALA VFQKAKGLPSPRSL------------------------------LAHIHTLTGQTFAKLD ------------------------------------------------------------ ------QPHCAL-----HYYRKAVEVDFSCLGALYQ------------------------ ---------------------------------------------------------SAL VFRQLGNP----------KAEMEALHLLYSAVQLQSD-KSL---SS-------------- ---------FSL----------------------------------VSPAM--------- ------------------------------------------------------------ -------LLGGEQMSFISRVPS-------------------------------------- -------------------------------PSLILHTL--------------------- --------------ANTCVLN--------------------------------------- ------------------------------------------------------------ -----GSISD----------GVECY----------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ LDL--------------------------------------------------------- ------------------------------------------------------------ -----LTSLR-SDG---------------------------------------------- -------------------------------------------------------KGL-- ------------------------------------------------------------ ---------------------------------------------V------P------- -----TENGTC-FPRIPEVYLEAGFALLKAQRYRDA------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ LVVCE------------------------------------------------------- ---------------------------------------------------------EVI TSTLDF-----IPERLLL------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------DAAE------------------- -----------------------K------------------------------------ -QHLADSDAALENMD--------------FVLWAGA------------------------ ------------------------------------------------------------ ------------------------------------------------------ARLLQA QAHRKL--KDTKEAITHFTRAINQLVKVFVK----------------------------- ------------QK---------------D------------------------------ -----------WKEKHPG--NSEVMV---------------------------------- ----------------------DKV-----------------ST---------------- -----------------------LETA--------------------------------- --------------------------------------------KGHSLAGRGLCFLES- ---------------------------------------------------------GQL KEALRDLHLGL------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------QMSP------------------------ ----------------------------------------GCKNTEMW------------ ---------------------------------------LAEVLWRL------------- ----------------------------------------------------DRREEALA H---------------------W------------------------REAHSIS-----D R-P-------KS-----------------------IK----------------------- ------------------LPLFLQAW---------------------------------- -----------------------------------------------------PEE-TAF DFSDLNKK----------------------------------------MEEYIQAK---- ------------------------------------------------------------ ---------NAK-T------------------------ >ENSDCDP00000014578 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------M-----------AD-------------------------- ------------------------------------------------RAGGG------- ------LLRGWVDESNAIVTAWQECE-SR------------------------------- ------------------------------------------------------------ -----------------------GESEH-------------------------------- --------SARTQ---------------------------------------------FY EKSCKLLQKM-------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------H----------------------------------G--- -------------------------------------------VPPVSSQVE-------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------LEMTLVYNTFLFSLT- -CPQHFDVQE--NLSRTLIR----------------------------------ALEALG -SQA---LTS--DLVAL---------------WRLV------------------------ ------------------------------------------------------------ ---------LKTLS-DAGFLACVHKLLC-------------------------------- ------------------------------------------------------------ ---------------------------VQW------------------------------ ---------------------------ALWLSSGHLQNIHCL------------------ ---------------------------------------------------------LLI VTQ----------------------GETR----------TPS------------------ --DDLMT-----VIRNLGLSSDEKSSL--------------------------------- ---------------------------------------------------------LVA VATSVLKDLLH-------------------------------------------I----- ---------------CTVVAQGI--------ERLRQGSH----------------AEALQ AFLHATCLPAPRRL------------------------------FAQVHTLAGLTFAKLD ------------------------------------------------------------ ------QPYSAL-----QCNRKALEVDFGCLSALYQ------------------------ ---------------------------------------------------------SSL IYRGLKKT----------EAEIEALQLLYSATTLRSN-VPP---ASA------------- --------VVPL----------------------------------ISSDM--------- ------------------------------------------------------------ -------LLSCKYFKSIITAPS-------------------------------------- -------------------------------SLHILYSL--------------------- --------------AHACALH--------------------------------------- ------------------------------------------------------------ -----NRFSE----------AVEHY----------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ LDL--------------------------------------------------------- ------------------------------------------------------------ -----LALLQ-SDF---------------------------------------------- -------------------------------------------------------MQT-- ------------------------------------------------------------ ---------------------------------------------V------C------- -----TEGNVAVFPRIPAVYLEAAFTMLSAKKFWDA------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ AAVCE------------------------------------------------------- ---------------------------------------------------------EVI SKTADL-----IPEKLVLV---------------------------P------------- ------------------------------------------------------------ ------------------------------------------------------------ --------LAEEDFP----APAVPSIL--------------------------------- --------------------------------------------------ESTES----- ---------------RRL-------------------D---------------------- ------------------------------------------------------------ ------------RLD--------------CVLWAGA------------------------ ------------------------------------------------------------ ------------------------------------------------------SYCLQG HAYYQM--KETNESVTIYSRCLNLLAKVSLK----------------------------- --RLAIAGQPVGEK---------------DP----------------------------- ------------------------------------------------------------ ----------------------PKF-----------------ET---------------- -----------------------LQRL--------------------------------- --------------------------------------------RGLVLAGRGMCFMDQ- ---------------------------------------------------------GQW KEALRDLKLSL------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------QTSP------------------------ ----------------------------------------GLQNAQYA------------ ---------------------------------------LTEVYWRL------------- ----------------------------------------------------GRKEEAIT C---------------------W------------------------KES---------- --VIMPVETPSA-----------------------GD----------------------- ------------------FPLYLQGF---------------------------------- -----------------------------------------------------SEDSLSF DLNDLRKR----------------------------------------MGEVCQTS---- ------------------------------------------------------------ ---------GLS-A------------------------ >ENSCHAP00000041952 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------M--------------------------------------- --------------------------------------------------DAY------- ------LLEKWTQANNSFVKEWKVTD-GR------------------------------- ------------------------------------------------------------ -----------------------IGGNH-------------------------------- --------GVKEK---------------------------------------------CH KGTLKLLQKI-------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------Q----------------------------------G--- -------------------------------------------VPAVIELIQ-------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------LELAVAYNTLVFSLN- -LSSLSDVQQ--SLTYTLLR----------------------------------ALEAVD -CQT---SSM--DPIVL---------------WCVT------------------------ ------------------------------------------------------------ ---------LKSFS-NTSHLSCLHSLLC-------------------------------- ------------------------------------------------------------ ---------------------------VQW------------------------------ ---------------------------ALWLASCQMQSIRHL------------------ ---------------------------------------------------------LRD VTQ----------------------EEVT----------ASS------------------ --QDLRT-----VIQKLSLSEKENSNL--------------------------------- ---------------------------------------------------------LVA VTAREFKDLLP-------------------------------------------I----- ---------------CTILLEGL--------ENITQENY----------------SAALV AFLQAASLPAPRTL------------------------------LAQVHTLTGFAFAKLD ------------------------------------------------------------ ------QPQSAL-----QSYRKAMEVDFGCHSALYQ------------------------ ---------------------------------------------------------SAL VYRQLKNT----------QAEIEALRLLHSA----------------------------- -----------LV-----QH--TEEQTVNTRVM------------IISPDV--------- ------------------------------------------------------------ -------LLSSKCKDSIMAVPS-------------------------------------- -------------------------------PQLILHSL--------------------- --------------ACTCVLE--------------------------------------- ------------------------------------------------------------ -----DRILE----------AVELY----------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ LDL--------------------------------------------------------- ------------------------------------------------------------ -----MSSLQ-SDI---------------------------------------------- -------------------------------------------------------TQP-- ------------------------------------------------------------ ---------------------------------------------V------C------- -----TEADVS-LPRVPVVYLEAAFTLLRAKRMWDV------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ITVCE------------------------------------------------------- ---------------------------------------------------------EVI TKTMNL-----IPERLV------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------L-------------------DLSE------------------- -----------------------EH-----LLF---------SMEGPSK----------S LKH--------ERLE--------------YVLWAAA------------------------ ------------------------------------------------------------ ------------------------------------------------------AHYLQG LAYCKM--KDTKESVANFTRSLNWLAKVSIKSTGT-----LVGDQGDCE----------- VVK--------------------------------------------------------- ------------------------------------------------------------ -------------------------------------------T---------------- -----------------------LQRL--------------------------------- --------------------------------------------RGLALAGRGVSFMER- ---------------------------------------------------------GQL KEALRDLKLSL------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------QSIT------------------------ ----------------------------------------ELQMIKFG------------ ---------------------------------------LVEVYRRL------------- ----------------------------------------------------GRQEEAIV C---------------------W------------------------RESQSSS-----E A-V-------SS-----------------------GN----------------------- ------------------LPLYLQTF---------------------------------- -----------------------------------------------------PEVSLCF DINYLKKA----------------------------------------MEDTFQRR---- ------------------------------------------------------------ ---------GVF-T------------------------ >ENSECRP00000010512 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------M-----------D--------------------------- -------------------------------------------------EGSGPRR---- ----RSCLQMWTEENNAIVAKWEEDK-KN------------------------------- ------------------------------------------------------------ -----------------------KQ----------------------------------- -------RTVLSP---------------------------------------------CF IELSKLLQTI-------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------Q----------------------------------G--- -------------------------------------------LPPAPASIP-------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------VEVAVFYNVTLFSLS- -TSDKMILDE-NKIINVLQR----------------------------------VVEASG -GYS---RNS--DILGL---------------WCSA------------------------ ------------------------------------------------------------ ---------LPVFY-DNSCITSLHQLAC-------------------------------- ------------------------------------------------------------ ---------------------------LQW------------------------------ ---------------------------ALWLLDCQLEKILDF------------------ ---------------------------------------------------------FCV LSKY----------------EGWSSSTSE----------RSS------------------ --GDILK-----FMQKISFSADASPLL--------------------------------- ---------------------------------------------------------LHV MSAGELKDQLY-------------------------------------------S----- ---------------CTVLAHGM--------EILAAGKY----------------LEAAQ IFKEATSLSLSMKM------------------------------QSKIFTLSGVCLQNLG ------------------------------------------------------------ ------KPQTAL-----QSFRRALEADFSCLYALYQ------------------------ ---------------------------------------------------------SSL VYRQLGMA----------DAEFETLHLLCRAVSVPEK-QDL---LFD------------- --------DLKL----------------------------------IDPDK--------- ------------------------------------------------------------ -------MLRNPALIKMFKKPS-------------------------------------- -------------------------------ITSVKYCL--------------------- --------------AQRSLES--------------------------------------- ------------------------------------------------------------ -----GRIDD----------AVEQY----------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ LDL--------------------------------------------------------- ------------------------------------------------------------ -----LEVFQ-EEK---------------------------------------------- -------------------------------------------------------NQE-- ------------------------------------------------------------ ---------------------------------------------V------F------- -----TGSIVS-LPRIPEIYLEAAASLFKAKKFWDA------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ TLVCE------------------------------------------------------- ---------------------------------------------------------EVI KRIASI-----VPEKLTIA---------------------------VPL----------- ------------------------------------------------------------ ---------------------------------------------------KDS------ ------------EGC----IPAKSESFFT------------------------------- ------------------------------QLKSHYQKEEYSE----------------- -------------------------------------TVQE------------------- -----------------------E------------------------------------ -KN--------EKLN--------------CILWTAA------------------------ ------------------------------------------------------------ ------------------------------------------------------AYFYQG WAFTEL--KDTKESITHLSRCINLLLTVHIV----------------------------- ------------QS---------------D------------------------------ ----------------------------------------------------GD------ ----------CINNSEMGKITREAV-----------------KL---------------- -----------------------LHRL--------------------------------- --------------------------------------------KGLAFVRRGISFMER- ---------------------------------------------------------GQE KEALLNFQLSQ------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------QSFP------------------------ ----------------------------------------ESVDGAFW------------ ---------------------------------------LLEALWRF------------- ----------------------------------------------------GRKDEAVS Y---------------------W------------------------QKLQESR-----Q S-V-------VD-----------------------IN----------------------- ----------NIHRD-TVLFLLPQ------------------------------------ ------------------------------------------------------QELSTS DLETLNKK----------------------------------------IEEY--RS---- ------------------------------------------------------------ ---------QAK-P------------------------ >ENSORLP00020010812 MRP-------------------PL------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------DDEHTGHAVHRYDYRGQQRNCSTVIFCVYFRL SRDFADEGNSNNLHLNCFSKM-----------N--------------------------- -------------------------------------------------QQQS------- ------LFNYWTQENNELVRNFKKQE-GQ---------------------NAVGPHL--- ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------------T SGFQKLLRKI-------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------Q----------------------------------G--- -------------------------------------------VPPETDHAQ-------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------LELSVVYNACICLIS- -QSQFTEAEL--LLKQATER----------------------------------ILQMKW -ENL---CQS--DAPIL---------------WITA------------------------ ------------------------------------------------------------ ---------IRSVE-NTALHPFLLLLPC-------------------------------- ------------------------------------------------------------ ---------------------------LQW------------------------------ ---------------------------AIWLATCQLKPIKDFQ----------------- -------------------------------------------------------E---- ------------------------------------------------------------ ------------------------NSVFDALSSG-------------------------- ----------------------------------------VGGDCGEDAKETSKKVPLLV MDPQRFTELLQ-------------------------------------------I----- ---------------CRVIVQSA--------EQMNEGRS----------------SEALP LLQAASKLPAPKTL------------------------------VAYTHLLSGSCLAHMN ------------------------------------------------------------ ------FPQMAL-----HCYKKALETDAQCVYALHQ------------------------ ---------------------------------------------------------STV VYSELGNT----------QAEIQALHIMHSTLLLPSP-AEP---STA------------- --------GVQL----------------------------------LSPSL--------- ------------------------------------------------------------ -------LLGSQSLKDLLSVPS-------------------------------------- -------------------------------ALSVLHRL--------------------- --------------ALKCILS--------------------------------------- ------------------------------------------------------------ -----GRVSE----------GVKHY----------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ LDL--------------------------------------------------------- ------------------------------------------------------------ -----LATLH-SED---------------------------------------------- -------------------------------------------------------HHR-- ------------------------------------------------------------ ---------------------------------------------I-----KV------- -----HSEFST-LPRLPKLYLEAAVALLIAQRPADS------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ MALCM------------------------------------------------------- ---------------------------------------------------------EVI DSTLEL-----LPEAVVIE---------------------------EPEEGSEA------ ------------------------------------------------------------ ------------------------------------------------------MQEEG- ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------E------------------- ------------------------------------------------------------ -----------DRVA--------------ALLWAAA------------------------ ------------------------------------------------------------ ------------------------------------------------------AYLLQG QCYSQL--KDWKQAVTHYTRCVNMLVKVHFK----------------------------- ------------RR---------------DVQTDISQAGR-----------------HLS ------------------------------------------QT---------------- ----------------------ANL-----------------HI---------------- -----------------------LQRL--------------------------------- --------------------------------------------KGLSLAGRGISFSQM- ---------------------------------------------------------DHL KEALRDLQLSL------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------QALP------------------------ ----------------------------------------EGIGAGLW------------ ---------------------------------------CGEVLWRL------------- ----------------------------------------------------DRKREAAA R---------------------W------------------------EATWSLP-----T Q-S-------LT-----------------------ES----------------------- ------------------FPLYAQEP---------------------------------- -----------------------------------------------------SFG-PLL DSTELRHR----------------------------------------TQEL-------- ------------------------------------------------------------ ----------GP-V------------------------ >ENSORLP00015000584 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------M-----------N--------------------------- -------------------------------------------------QQQS------- ------LFDYWTEENNELVRNCK--E-GQ---------------------NAVGPHL--- ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------------T SGFQKLLRKI-------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------Q----------------------------------G--- -------------------------------------------VPPETDHAQ-------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------LELSVVYNACICLIS- -QSQFTEAEL--LLKQATER----------------------------------ILQMKG -ENL---CQS--DAPIL---------------WITA------------------------ ------------------------------------------------------------ ---------IRSVE-NTALHPFLLLLPC-------------------------------- ------------------------------------------------------------ ---------------------------LQW------------------------------ ---------------------------AIWLATCQLKPIKDFQ----------------- -------------------------------------------------------E---- ------------------------------------------------------------ ------------------------TSVFDALGSG-------------------------- ----------------------------------------VGGDCGED--ETSTKVPLLV MDPKRFTELLQ-------------------------------------------I----- ---------------CRVIVQSA--------EQMNEGRS----------------SEALP LLQAASKLPAPKNL------------------------------VAYTHLLSGSCLAHMN ------------------------------------------------------------ ------CPQMAL-----HCYKKALETDAQCVYALHQ------------------------ ---------------------------------------------------------STL IYSELGNT----------QAEIQALHIMHSTLLLPSP-AEP---STA------------- --------GVQL----------------------------------LSPSL--------- ------------------------------------------------------------ -------LLGSQSLKNLLSVPS-------------------------------------- -------------------------------ALSVLHRL--------------------- --------------ALKCILS--------------------------------------- ------------------------------------------------------------ -----GRVSE----------GVKHY----------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ LDL--------------------------------------------------------- ------------------------------------------------------------ -----LATLH-SED---------------------------------------------- -------------------------------------------------------HHR-- ------------------------------------------------------------ ---------------------------------------------V-----KV------- -----HSEFST-LPRLPKLYLEAAVALLMAQRPADS------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ MALCM------------------------------------------------------- ---------------------------------------------------------EVI DSTLEL-----LPETVVIE---------------------------EPEEGSEA------ ------------------------------------------------------------ ------------------------------------------------------MQEEG- ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------E------------------- ------------------------------------------------------------ -----------DRVA--------------ALLWGAA------------------------ ------------------------------------------------------------ ------------------------------------------------------AYLLQG QCYSQL--KDWKQAVTHYTRCVNILVKVHFK----------------------------- ------------RR---------------DVQTDVSQAGR-----------------HLS ------------------------------------------QT---------------- ----------------------ANL-----------------HI---------------- -----------------------LQRL--------------------------------- --------------------------------------------KGLSLAGRGISFSQM- ---------------------------------------------------------DHL KEALRDLQLSI------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------QALP------------------------ ----------------------------------------EGIGAGLW------------ ---------------------------------------CGEVLWRL------------- ----------------------------------------------------DRKREAAA R---------------------W------------------------EATWSLP-----T Q-S-------LT-----------------------ES----------------------- ------------------FPLYAQEP---------------------------------- -----------------------------------------------------SFG-PLL DSTELRHR----------------------------------------IQEL-------- ------------------------------------------------------------ ----------GP-V------------------------ >ENSOMEP00000023967 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------M-----------H--------------------------- -------------------------------------------------RQQS------- ------LFDYWTQENNDLVKICKKHE-GQ---------------------KAVGPHL--- ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------------T SDFQKLLRKI-------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------Q----------------------------------G--- -------------------------------------------VPPETDHAQ-------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------LELSVVYNACICFIA- -QSQFTEAEL--LLKQAAER----------------------------------TLQMKG -ESL---CQL--DAPIV---------------WMTA------------------------ ------------------------------------------------------------ ---------VKSVK-NTALHRFLLFLPC-------------------------------- ------------------------------------------------------------ ---------------------------LQW------------------------------ ---------------------------AIWLATCQLKPIEDFQ----------------- -------------------------------------------------------E---- ------------------------------------------------------------ ------------------------TSLFEAIIGG-------------------------- ----------------------------------------VGGEFGEHAKEKFRIVPTLV MDPKRLVELLQ-------------------------------------------I----- ---------------CSVIAQGA--------EKLNEGRG----------------SEALP RLQAASKLPAPKAL------------------------------VAYTHLLSGSCLTHMN ------------------------------------------------------------ ------CPQMAL-----QCYKKALETDAQCVYALHQ------------------------ ---------------------------------------------------------SSR IYSELGNA----------QAEIQALHILHLTLLLPSS-AEP---STA------------- --------GVHL----------------------------------LSPFL--------- ------------------------------------------------------------ -------LLASQSLKNLLSVPS-------------------------------------- -------------------------------PLSVLHKL--------------------- --------------ALKCILN--------------------------------------- ------------------------------------------------------------ -----IRVPE----------GVKHY----------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ LDL--------------------------------------------------------- ------------------------------------------------------------ -----LAALH-SED---------------------------------------------- -------------------------------------------------------HHG-- ------------------------------------------------------------ ---------------------------------------------V-----KV------- -----HSEFST-LPRLPKLYLEAAVALLMAQRPADS------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ MALCT------------------------------------------------------- ---------------------------------------------------------EVI ETTLEL-----LPEKLVIE---------------------------EPEEGSEAL----- ------------------------------------------------------------ ---------------------------------------------------TQGMREEG- ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------E------------------- ------------------------------------------------------------ -----------GTLA--------------VFLWAAA------------------------ ------------------------------------------------------------ ------------------------------------------------------AYLLQG HCYSQL--KDWKQAVTHYTRCVNMLVKVHFK----------------------------- ------------RK---------------DVQTEVSKAGR-----------------HLS ------------------------------------------QT---------------- ----------------------ADL-----------------HI---------------- -----------------------LQRL--------------------------------- --------------------------------------------KGLSLAGRGISFSQM- ---------------------------------------------------------DHL KEALRDLQLSL------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------QAVP------------------------ ----------------------------------------EGIGAGLW------------ ---------------------------------------CGEVLWRL------------- ----------------------------------------------------DRKREAAA RS-----------DVSLPTVGL-------------------------------------- ------------------------------------------------------------ -------------------PLYAQEP---------------------------------- -----------------------------------------------------SFG-PSL DPTELRHR----------------------------------------IQKL-------- ------------------------------------------------------------ ----------GP-V------------------------ >ENSNBRP00000006174 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------M-----------Y--------------------------- -------------------------------------------------QPTS------- ------LLEKWSQENNELVNKCK------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------V------- ----------------------GK--------------------------------AAIL TSN--------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------KTLELAVVYNTCVCFTA- -QSQFSEAEL--LLKEATER----------------------------------VLQVTG -NNA---DTS--DPLVL---------------WRAG------------------------ ------------------------------------------------------------ ---------LKSAG-NTALHPHVLYLLC-------------------------------- ------------------------------------------------------------ ---------------------------LQW------------------------------ ---------------------------ALWLAKCQLENIWEL------------------ --------------------------------------------------------QMS- ------------------------------------------------------------ -------------------------SLCELVCDG-------------------------- ----------------------------------------VGDGSPSEAKGRLSKSPLLV MELKRLTELLQ-------------------------------------------I----- ---------------CTSIAQGA--------EKLNEGRS----------------SEALS DLQAASALSATRAL------------------------------VAYTHLLSGSCLAHMN ------------------------------------------------------------ ------RPQMAL-----QCYKRALETDSRCVCALYR------------------------ ---------------------------------------------------------SML IYRQLGNT----------QAEIQALRLLHSTLMLPPA-TEP---VLG------------- --------GIHP----------------------------------LSPSL--------- ------------------------------------------------------------ -------LLSSHSLSRLLLVPS-------------------------------------- -------------------------------ALSVLYSL--------------------- --------------ALKCVLS--------------------------------------- ------------------------------------------------------------ -----GRVTE----------GVEHY----------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ LDL--------------------------------------------------------- ------------------------------------------------------------ -----LAALH-SED---------------------------------------------- -------------------------------------------------------QHA-- ------------------------------------------------------------ ---------------------------------------------V-----RV------- -----DAEVSV-LPRMPELYLEAGAALLFTRRPADC------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ MALCN------------------------------------------------------- ---------------------------------------------------------EVI STTLEL-----VPEKVVLE---------------------------EPDEGIGGD----- ------------------------------------------------------------ ---------------------------------------------------ARGLSVEG- ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------E------------------- ------------------------------------------------------------ -----------DKVA--------------MLLWAAA------------------------ ------------------------------------------------------------ ------------------------------------------------------AYLLQG HCHAHL--KDWKQAVTHYTRCINLLVKVHLK----------------------------- ------------NR---------------D------------------------------ -----------FQPQIPA----------A-------DV-NVKHG---------------- ----------------------KDL-----------------CA---------------- -----------------------LQRM--------------------------------- --------------------------------------------KGLSLAWRGISFTQM- ---------------------------------------------------------DQL REALRDLQLSL------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------QAFP------------------------ ----------------------------------------DYTGAGLW------------ ---------------------------------------CGEVLWRL------------- ----------------------------------------------------GRKHEAAA C---------------------W------------------------EKTWSLT-----T Q-T-------SV-----------------------EK----------------------- ------------------LPLYLQDP---------------------------------- -----------------------------------------------------QSG-PLL DSVELRLR----------------------------------------IQEL-------- ------------------------------------------------------------ ----------GL-T------------------------ >ENSPNYP00000024241 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------M-----------Y--------------------------- -------------------------------------------------QPPS------- ------LLEKWSQENNELVNKCK------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------V------- ----------------------GK--------------------------------AAIL TSN--------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------KTLELAVVYNTCVCFTA- -QSQFSEAEL--LLKEATER----------------------------------VLQVTG -NNA---DTS--DPLVL---------------WRAG------------------------ ------------------------------------------------------------ ---------LKSAG-NTALHPHVLYLLC-------------------------------- ------------------------------------------------------------ ---------------------------LQW------------------------------ ---------------------------ALWLAKCQLENIGEL------------------ --------------------------------------------------------QMS- ------------------------------------------------------------ -------------------------SLCEIVCDG-------------------------- ----------------------------------------VGDGSPSEAKGRLSKSPLLV MEPKRLTELLQ-------------------------------------------I----- ---------------CTSIAQGA--------EKLNEGRS----------------SEALS DLQAASALPATRAL------------------------------VAYTHLLSGSCLAHMN ------------------------------------------------------------ ------RPQMAL-----QCYKKALETDSRCVCALYR------------------------ ---------------------------------------------------------SML IYRQLGNT----------QAEIQALRLLHSTLMLPPA-TEP---VLG------------- --------GIQP----------------------------------LSPSL--------- ------------------------------------------------------------ -------LLSSQSLSRLLSVPS-------------------------------------- -------------------------------ALSVLYSL--------------------- --------------ALKCVLS--------------------------------------- ------------------------------------------------------------ -----GRVTE----------GVEHY----------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ LDL--------------------------------------------------------- ------------------------------------------------------------ -----LAALH-SED---------------------------------------------- -------------------------------------------------------QHA-- ------------------------------------------------------------ ---------------------------------------------V-----RV------- -----DAEVSV-LPRMPELYLEAGTALLFTRRPADC------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ MAFCN------------------------------------------------------- ---------------------------------------------------------EVI STTLEL-----VPEKVVLE---------------------------EPEEGIGGD----- ------------------------------------------------------------ ---------------------------------------------------ARGLSVEG- ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------E------------------- ------------------------------------------------------------ -----------DKVA--------------MLLWAAA------------------------ ------------------------------------------------------------ ------------------------------------------------------AYLVQG HCHAHL--KDWKQAVTHYTRCINLLVKVHLK----------------------------- ------------NR---------------D------------------------------ -----------FQPQIPA----------A-------DV-NVKHG---------------- ----------------------KDL-----------------CT---------------- -----------------------LQRM--------------------------------- --------------------------------------------KGLSLAWRGISFTQM- ---------------------------------------------------------DQL REALRDLQLSL------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------QAFP------------------------ ----------------------------------------DYTGAGLW------------ ---------------------------------------CGEVLWRL------------- ----------------------------------------------------GRKHEAAA C---------------------W------------------------EKTWSLT-----T Q-T-------SV-----------------------EK----------------------- ------------------LPLYLQDP---------------------------------- -----------------------------------------------------QSG-PLL DSVELRLR----------------------------------------IQELVP------ ------------------------------------------------------------ --------PV---------------------------- >ENSHBUP00000008606 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------M-----------Y--------------------------- -------------------------------------------------QPPS------- ------LLEKWSQENNELVNKCKQQE-AG------------------------------- -------------------------------------------GGAV------------- ----------------------SRDHRQ-------------------------------- --------SSLRW---------------------------------------------CS SEFHKLLRKI-------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------Q----------------------------------G--- -------------------------------------------IPPHVDHSQ-------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------LELAVVYNTCVCFTA- -QSQFSEAEL--LLKEATER----------------------------------VLQVTG -NNA---DTS--DPLVL---------------WRAG------------------------ ------------------------------------------------------------ ---------LKSAG-NTALHPHVLYLLC-------------------------------- ------------------------------------------------------------ ---------------------------LQW------------------------------ ---------------------------ALWLAKCQLENIGELQ----------------- -------------------------------------------------------EQMS- ------------------------------------------------------------ -------------------------SLCEIVCDG-------------------------- ----------------------------------------VGDCSPSEAKGRLSKSPLLV MEPKRLTELLQ-------------------------------------------I----- ---------------CTSIAQGA--------EKLNEGRS----------------SEALS DLQAASALPATRAL------------------------------VAYTHLLSGSCLAHMN ------------------------------------------------------------ ------RPQMAL-----QCYKRALETDSRCVCALYR------------------------ ---------------------------------------------------------SML IYRQLGNT----------QAEIQALRLLHSTLMLPPA-TEP---VLG------------- --------GIQP----------------------------------LSPSL--------- ------------------------------------------------------------ -------LLSSQSLSRLLSVPS-------------------------------------- -------------------------------ALSVLYSL--------------------- --------------ALKCVLS--------------------------------------- ------------------------------------------------------------ -----GRVTE----------GVEHY----------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ LDL--------------------------------------------------------- ------------------------------------------------------------ -----LAALH-SED---------------------------------------------- -------------------------------------------------------QHA-- ------------------------------------------------------------ ----------------------------------------------------V------- -----DAEVSV-LPRMLELYLEAGTALLFTRRPADC------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ MAFCN------------------------------------------------------- ---------------------------------------------------------EVI STTLEL-----VPEKVVLE---------------------------EPEEGIGGD----- ------------------------------------------------------------ ---------------------------------------------------ARGLSVEG- ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------E------------------- ------------------------------------------------------------ -----------DKVA--------------MLLWAAA------------------------ ------------------------------------------------------------ ------------------------------------------------------AYLLQG HCHTHL--KDWKQAVTHYTRCINLLVKVHLK----------------------------- ------------NR---------------D------------------------------ -----------FQPQIPA----------A-------DV-NVKHG---------------- ----------------------KDL-----------------CT---------------- -----------------------LQRM--------------------------------- --------------------------------------------KGLSLAWRGISFTQM- ---------------------------------------------------------DQL REALRDLQLSL------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------QAFP------------------------ ----------------------------------------DYTGAGLW------------ ---------------------------------------CGEVLWRL------------- ----------------------------------------------------GRKHEAAA C---------------------W------------------------EKTWSLT-----T Q-T-------SV-----------------------EK----------------------- ------------------LPLYLQDP---------------------------------- -----------------------------------------------------QSG-PLL DSVELRLR----------------------------------------IQEL-------- ------------------------------------------------------------ ----------GL-T------------------------ >ENSACLP00000003402 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------M-----------Y--------------------------- -------------------------------------------------QPPS------- ------LLEKWSQENNELVNKCKQQE-AA------------------------------- -------------------------------------------GGAV------------- ----------------------SRDHRQ-------------------------------- --------SSLRW---------------------------------------------CS SEFHKLLRKI-------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------Q----------------------------------G--- -------------------------------------------IPPHVDHSQ-------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------LELAVVYNTCVCFTA- -QSQFSEAEL--LLKEATER----------------------------------VLQVTG -NNA---DTS--DPLVL---------------WRAG------------------------ ------------------------------------------------------------ ---------LKSAG-NTALHPHVLYLLC-------------------------------- ------------------------------------------------------------ ---------------------------LQW------------------------------ ---------------------------ALWLAKCQLENIGELQ----------------- -------------------------------------------------------EQMS- ------------------------------------------------------------ -------------------------SLCEIVCDG-------------------------- ----------------------------------------VGDCSPSEAKGRLSKSPLLV MEPKRLTELLQ-------------------------------------------I----- ---------------CTSIAQGA--------EKLNEGRS----------------SEALS DLQAASALPATRAL------------------------------VAYTHLLSGSCLAHMN ------------------------------------------------------------ ------RPQMAL-----QCYKRALETDSRCVCALYR------------------------ ---------------------------------------------------------SML IYRQLGNT----------QAEIQALRLLHSTLMLPPA-TEP---VLG------------- --------GIQP----------------------------------LSPSL--------- ------------------------------------------------------------ -------LLSSQSLSRLLSVPS-------------------------------------- -------------------------------ALSVLYSL--------------------- --------------ALKCVLS--------------------------------------- ------------------------------------------------------------ -----GRVTE----------GVEHY----------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ LDL--------------------------------------------------------- ------------------------------------------------------------ -----LAALH-SED---------------------------------------------- -------------------------------------------------------QHA-- ------------------------------------------------------------ ----------------------------------------------------V------- -----DAEVSV-LPRMPELYLEAGTALLFTWRPADC------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ MAFCN------------------------------------------------------- ---------------------------------------------------------EVI STTLEL-----VPEKVVLE---------------------------EPEEGIGGD----- ------------------------------------------------------------ ---------------------------------------------------ARGLSVEG- ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------E------------------- ------------------------------------------------------------ -----------DKVA--------------MLLWAAA------------------------ ------------------------------------------------------------ ------------------------------------------------------AYLVQG HCHAHL--KDWKQAVTHYTRCINLLVKVHLK----------------------------- ------------NR---------------D------------------------------ -----------FQPQIPA----------A-------DV-NVKHG---------------- ----------------------KDL-----------------CT---------------- -----------------------LQRM--------------------------------- --------------------------------------------KGLSLAWRGISFTQM- ---------------------------------------------------------DQL REALRDLQLSL------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------QAFP------------------------ ----------------------------------------DYTGAGLW------------ ---------------------------------------CGEVLWRL------------- ----------------------------------------------------GRKHEAAA C---------------------W------------------------EKTWSLT-----T Q-T-------SV-----------------------EK----------------------- ------------------LPLYLQDP---------------------------------- -----------------------------------------------------QSG-PLL DSVELRFR----------------------------------------IQEL-------- ------------------------------------------------------------ ----------GF-T------------------------ >ENSMZEP00005022589 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------M-----------Y--------------------------- -------------------------------------------------QPPS------- ------LPEKWSQENNELVNKCKQQE-AA------------------------------- -------------------------------------------GGAV------------- ----------------------SRDHRQ-------------------------------- --------SSLRW---------------------------------------------CS SEFHKLLRKI-------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------Q----------------------------------G--- -------------------------------------------IPPHVDHSQ-------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------LELAVVYNTCVCFTA- -QSQFSEAEL--LLKEATER----------------------------------VLQVTG -NNA---DTS--DPLVL---------------WRAG------------------------ ------------------------------------------------------------ ---------LKSAG-NTALHPHVLYLLC-------------------------------- ------------------------------------------------------------ ---------------------------LQW------------------------------ ---------------------------ALWLAKCQLENIGELQ----------------- -------------------------------------------------------EQMS- ------------------------------------------------------------ -------------------------SLCEIVCDG-------------------------- ----------------------------------------VGDGSLSEAKGRLSKSPLLV MEPKRLTELLQ-------------------------------------------I----- ---------------CTSIAQGA--------EKLNEGRS----------------SEALS VLQAASALPATRAL------------------------------VAYTHLLSGSCLAHMN ------------------------------------------------------------ ------RPQMAL-----QCYKRALETDSRCVCALYR------------------------ ---------------------------------------------------------SML IYRQLGNT----------QAEIQALRLLHSTLMLPPA-TEP---VLG------------- --------GIQP----------------------------------LSPSL--------- ------------------------------------------------------------ -------LLSSQSLSRLLSVPS-------------------------------------- -------------------------------ALSVLYSL--------------------- --------------ALKCVLS--------------------------------------- ------------------------------------------------------------ -----GRVTE----------GVEHY----------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ LDL--------------------------------------------------------- ------------------------------------------------------------ -----LAALH-SED---------------------------------------------- -------------------------------------------------------QHA-- ------------------------------------------------------------ ----------------------------------------------------V------- -----DAEVSV-LPRMPELYLEAGTALLFTRRPADC------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ MAFCN------------------------------------------------------- ---------------------------------------------------------EVI STTLEL-----VPEKVVLE---------------------------EPEEGIGGD----- ------------------------------------------------------------ ---------------------------------------------------ARGLSVEG- ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------E------------------- ------------------------------------------------------------ -----------DKVA--------------MLLWAAA------------------------ ------------------------------------------------------------ ------------------------------------------------------AYLVQG HCHAHL--KDWKQAVTHYTRCINLLVKVHLK----------------------------- ------------NR---------------D------------------------------ -----------FQPQIPA----------A-------DV-NVKHG---------------- ----------------------KDL-----------------CT---------------- -----------------------LQRM--------------------------------- --------------------------------------------KGLSLAWRGISFTQM- ---------------------------------------------------------DQL REALRDLQLSL------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------QAFP------------------------ ----------------------------------------DYTGAGLW------------ ---------------------------------------CGEVLWRL------------- ----------------------------------------------------GRKHEAAA C---------------------W------------------------EKTWSLT-----T Q-T-------SV-----------------------EK----------------------- ------------------LPLYLQDP---------------------------------- -----------------------------------------------------QSG-PLL DSVELRFR----------------------------------------IQEL-------- ------------------------------------------------------------ ----------GL-T------------------------ >ENSONIP00000017184 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------M-----------Y--------------------------- -------------------------------------------------QPPS------- ------LLEKWIQENNELVNKCKQQE-AG------------------------------- -------------------------------------------GGVV------------- ----------------------SRDHSQ-------------------------------- --------SSLRW---------------------------------------------CS SEFHKLLRKI-------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------Q----------------------------------G--- -------------------------------------------IPPHVDHTQ-------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------LELAVVCNTCVCFTA- -QSQFSEAEL--LLKEATER----------------------------------VLQMTG -NNA---DTS--DPLVL---------------WRAV------------------------ ------------------------------------------------------------ ---------LKSAG-NTALHPHVLYLLC-------------------------------- ------------------------------------------------------------ ---------------------------LQW------------------------------ ---------------------------TLWLAKCQLENIGELQ----------------- -------------------------------------------------------EEMT- ------------------------------------------------------------ -------------------------SLCETVCDG-------------------------- ----------------------------------------VGDGSPSEAKRRLAKSPLLV MDPKRLTELLQ-------------------------------------------I----- ---------------CTSIAQGA--------EKLNEGRS----------------SEALS DLQAASTMPATRAL------------------------------VAYTHLLSGSCLAHMN ------------------------------------------------------------ ------RPQMAL-----QCYKKALETDSRCVCALYR------------------------ ---------------------------------------------------------SML IYRQLGNT----------QAEIQALRLLHSTLMLPPA-SEP---VLG------------- --------GIHP----------------------------------ISPSL--------- ------------------------------------------------------------ -------LLSSQSLSRLFSVPS-------------------------------------- -------------------------------ALSVLYSL--------------------- --------------ALKCVLS--------------------------------------- ------------------------------------------------------------ -----GRVTE----------GVEHY----------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ LDL--------------------------------------------------------- ------------------------------------------------------------ -----LAALH-SED---------------------------------------------- -------------------------------------------------------QHA-- ------------------------------------------------------------ ---------------------------------------------V-----KV------- -----DAEVSV-LPRMLELYLEAGTALLITRRPADC------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ MALCN------------------------------------------------------- ---------------------------------------------------------EVI STTLEL-----VPEKVVLE---------------------------EPEERIGGD----- ------------------------------------------------------------ ---------------------------------------------------ARGLSVEG- ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------E------------------- ------------------------------------------------------------ -----------DKVA--------------MLLWAAA------------------------ ------------------------------------------------------------ ------------------------------------------------------AYLLQG HCHAHL--KDWKQAVTHYTRCINLVVKVRLK----------------------------- ------------NR---------------D------------------------------ -----------FQPQIPA----------A-------DV-NVKHG---------------- ----------------------KDL-----------------CA---------------- -----------------------LQRM--------------------------------- --------------------------------------------KGLSLAWRGISFTQM- ---------------------------------------------------------DQL REALRDLQLSL------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------QAFP------------------------ ----------------------------------------DYTGAGLW------------ ---------------------------------------CGEVLWRL------------- ----------------------------------------------------GRKHEAAA C---------------------W------------------------EKTWSLT-----T Q-T-------SV-----------------------EK----------------------- ------------------LPLYLQDP---------------------------------- -----------------------------------------------------QSG-PLL DSVELRLR----------------------------------------IQEL-------- ------------------------------------------------------------ ----------GL-T------------------------ >ENSSPAP00000022701 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------M-----------A--------------------------- -------------------------------------------------PPLS------- ------LLDTWVQENNELVNKCKQK----------------------------------- --------G---------------------------------EQDAV------------- ----------------------SRDCSQ-------------------------------- --------PPLKW---------------------------------------------FS FEFHKLLRKI-------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------Q----------------------------------G--- -------------------------------------------IPPNADHTQ-------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------LELAVVFNAGVCSAA- -QSQVSEAEL--FLAQATER----------------------------------VLQMTG -GDA---GAS--DPLVR---------------WRTV------------------------ ------------------------------------------------------------ ---------LNSVG-DTALHPSVLYLLC-------------------------------- ------------------------------------------------------------ ---------------------------LQW------------------------------ ---------------------------AIWLATCQLKTIQEFQ----------------- -------------------------------------------------------E-MS- ------------------------------------------------------------ -------------------------ALFDTLCGG-------------------------- ----------------------------------------IGDGSVSEARPKSSNIPLLV MDPRRLIELLQ-------------------------------------------I----- ---------------CTSIALGA--------ERLNEGRS----------------SEALS SLQAASALPAPRAL------------------------------VAYTHLLSGSCLTHMR ------------------------------------------------------------ ------RPQMAL-----QCYRKALETDSRCVCALYQ------------------------ ---------------------------------------------------------SML IYRQLGNT----------QAEIQALRLLHSTLMLPSA-IEP---ALG------------- --------STHL----------------------------------LSPSL--------- ------------------------------------------------------------ -------LLRSQSLSSLLSVPS-------------------------------------- -------------------------------ALTVLHSL--------------------- --------------ALKCVLY--------------------------------------- ------------------------------------------------------------ -----GRVSE----------GVEHY----------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ LDL--------------------------------------------------------- ------------------------------------------------------------ -----LAVVH-SED---------------------------------------------- -------------------------------------------------------QQG-- ------------------------------------------------------------ ----------------------------------------------------L------- -----HTEDAT-LPKLPELYLEAGAALLMARRPADC------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ LALCN------------------------------------------------------- ---------------------------------------------------------EVN STTLEL-----LPEKVVLE---------------------------EPEERREAE----- ------------------------------------------------------------ ---------------------------------------------------TRDM--EG- ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------E------------------- ------------------------------------------------------------ -----------NSLA--------------MVLWTAA------------------------ ------------------------------------------------------------ ------------------------------------------------------AYLLQG HCHSHL--KDWKQAVTHYTRCINLLVKVRFK----------------------------- ------------KR---------------D------------------------------ -----------FQPQIPG----------A-------DM-DVKRG---------------- ----------------------KDL-----------------CV---------------- -----------------------LERL--------------------------------- --------------------------------------------KGLSLAGRGICFIQI- ---------------------------------------------------------DKL KEALRDLQLGL------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------QTFP------------------------ ----------------------------------------ECVGAGLW------------ ---------------------------------------CGEVLWRL------------- ----------------------------------------------------RRRREAAA C---------------------W------------------------EKTWSLT-----T Q-S-------LD-----------------------KS----------------------- ------------------LPVYLQEP---------------------------------- -----------------------------------------------------QSG-PLL DSTELRHR----------------------------------------IQEL-------- ------------------------------------------------------------ ----------GP-T------------------------ >ENSAOCP00000026117 MS---------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------HKM-----------S--------------------------- -------------------------------------------------QPPS------- ------LLDKWIQENNELVNKCKQE----------------------------------- --------K---------------------------------ERDTM------------- ----------------------RQDHNQ-------------------------------- --------PHLRW---------------------------------------------CS YEFHKLLRKI-------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------Q----------------------------------G--- -------------------------------------------IPPNTDHTQ-------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------LELAVVYNTGVCATA- -QSQFSEAQL--FLTQAAER----------------------------------VLQMTG -GET---GAS--DPLVC---------------WRAV------------------------ ------------------------------------------------------------ ---------LKSVE-NTHLHPTVLYLLC-------------------------------- ------------------------------------------------------------ ---------------------------LQW------------------------------ ---------------------------AIWLATCQLETIQEFQ----------------- -------------------------------------------------------EKMS- ------------------------------------------------------------ -------------------------SLFETLCGG-------------------------- ----------------------------------------VGDGGISEARSKSSNIPLLV MDPRRLIELLQ-------------------------------------------I----- ---------------CTSITLGA--------ERLTEGRS----------------SEALT GLQAASSLPAPRAL------------------------------VGYTHLLSGSCLTHMR ------------------------------------------------------------ ------RPQMAL-----QCYRKALETDSRCVCALYQ------------------------ ---------------------------------------------------------SML IYRQLGNT----------QAEIQALRLLHSTLMLPSA-TDP---ALA------------- --------STHL----------------------------------LSPSS--------- ------------------------------------------------------------ -------LLCSQSLSSLLSVPS-------------------------------------- -------------------------------ALSVLHSL--------------------- --------------ALKCLLY--------------------------------------- ------------------------------------------------------------ -----GRVSE----------GVEHY----------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ LDL--------------------------------------------------------- ------------------------------------------------------------ -----LAVLH-SED---------------------------------------------- -------------------------------------------------------QQG-- ------------------------------------------------------------ ----------------------------------------------------L------- -----HTQDAT-IPRLPELYLEAGAALLMARRPADC------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ LALCS------------------------------------------------------- ---------------------------------------------------------EVI STTLEL-----LPEKVVLE---------------------------EPEERREAE----- ------------------------------------------------------------ ---------------------------------------------------TRDM--EG- ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------E------------------- ------------------------------------------------------------ -----------NRVA--------------VVLWTAA------------------------ ------------------------------------------------------------ ------------------------------------------------------AYLLQG HCHSHL--KDWKQAVTHYTRCINLVVKVRFK----------------------------- ------------KR---------------D------------------------------ -----------FQPLIPS----------A-------DM-DVKQG---------------- ----------------------NDQ-----------------CV---------------- -----------------------LQRL--------------------------------- --------------------------------------------KGLSLAGRGISFTQT- ---------------------------------------------------------DKL KEALRDLQLSL------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------QAFP------------------------ ----------------------------------------ECVGAGLW------------ ---------------------------------------CGEVLWRL------------- ----------------------------------------------------SRRREAAA C---------------------W------------------------EKTWSLT-----T Q-S-------LV-----------------------KN----------------------- ------------------LPVYLQEP---------------------------------- -----------------------------------------------------QSG-PLL DSAELCHR----------------------------------------IQEL-------- ------------------------------------------------------------ ----------GP-N------------------------ >ENSAPEP00000029923 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------M-----------S--------------------------- -------------------------------------------------QPPS------- ------LLDKWIQENNELVNKCK------------------------------------- ------------------------------------------------------------ ------------------------DHNQ-------------------------------- --------PHLRW---------------------------------------------CS YEFHKLLRKI-------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------Q----------------------------------G--- -------------------------------------------IPPNADHTQ-------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------LELAVVYNAGVCATA- -QSQFSEAQL--FLTQAAER----------------------------------VLQMTG -GET---GAS--DPLVR---------------WRAV------------------------ ------------------------------------------------------------ ---------LKSVE-NTHLHPTVLYLLC-------------------------------- ------------------------------------------------------------ ---------------------------LQW------------------------------ ---------------------------AIWLATCQLETIQEFQ----------------- ---------------------------------------------------------MS- ------------------------------------------------------------ -------------------------SLFETLCGG-------------------------- ----------------------------------------VGDGGISEARSKSSNIPLLA MDPRRLIELLQ-------------------------------------------I----- ---------------CTSITLGA--------ERLTEGRS----------------SEALT GLQAALSLPAPRAL------------------------------VGYTHLLSGSCLTHMR ------------------------------------------------------------ ------RPQMAL-----QCYRKALETDSRCVCALYQ------------------------ ---------------------------------------------------------SML IYRQLGNT----------QAEIQALRLLHSTLMLPSA-TVP---ALA------------- --------STHL----------------------------------LSPSS--------- ------------------------------------------------------------ -------LLCSQSLSSLLSVPS-------------------------------------- -------------------------------ALSVLHSL--------------------- --------------ALKCLLY--------------------------------------- ------------------------------------------------------------ -----GRVSE----------GVEHY----------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ LDL--------------------------------------------------------- ------------------------------------------------------------ -----LAVLH-SED---------------------------------------------- -------------------------------------------------------QQG-- ------------------------------------------------------------ ---------------------------------------------V-----RL------- -----HTQDAT-IPRLPELYLEAGAALLMARRPADC------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ LALCS------------------------------------------------------- ---------------------------------------------------------EVI STTLEL-----LPEKVVLE---------------------------EPEKRREAE----- ------------------------------------------------------------ ---------------------------------------------------TRDM--EG- ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------E------------------- ------------------------------------------------------------ -----------NRVA--------------VVLWTAA------------------------ ------------------------------------------------------------ ------------------------------------------------------AYLLQG HCHSHL--KDWKQAVTHYTRCINLLVKVHFK----------------------------- ------------KR---------------D------------------------------ -----------FQPQIPS----------A-------DM-DVKQG---------------- ----------------------KDQ-----------------CV---------------- -----------------------LQRL--------------------------------- --------------------------------------------KGLSLAGRGISFTQT- ---------------------------------------------------------DKL KEALRDLQLSL------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------QAFP------------------------ ----------------------------------------ECVGAGLW------------ ---------------------------------------CGEVLWRL------------- ----------------------------------------------------SRRREAAA C---------------------W------------------------EKTWSLT-----T Q-S-------LV-----------------------KN----------------------- ------------------LPVYLQEP---------------------------------- -----------------------------------------------------QSG-PLL DSAELRHR----------------------------------------IQEL-------- ------------------------------------------------------------ ----------GP-N------------------------ >ENSSDUP00000020106 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------M-----------Y--------------------------- -------------------------------------------------RPTS------- ------LVNKWVQENNELVNKWK------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------V-PP----------LIPLCIFYLTPFPSPCPLPAG--- -------------------------------------------VPPLADHTH-------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------LELSVVYNTCVCATA- -QSQFTEAEL--LLTQALQR----------------------------------ALQITG -NDS---VTS--ETPVF---------------WRTV------------------------ ------------------------------------------------------------ ---------LKSVA-NTALNSCVLYLLC-------------------------------- ------------------------------------------------------------ ---------------------------LQW------------------------------ ---------------------------AIWLATCQLKTIQEFK----------------- ---------------------------------------------------------LC- ------------------------------------------------------------ -------------------------SLLETLCGG-------------------------- ----------------------------------------VGDDRRNETWGKSSDVPLLV TDPRKLVELLQ-------------------------------------------I----- ---------------CTSIAQGV--------ERLSEGQC----------------SEALS DLQSASSLPAPRAL------------------------------VAYVHLLSGS-----S C----------------------------------------------------------- ----IIRPQMAL-----QCYRKALETDSCCVCALYQ------------------------ ---------------------------------------------------------SML IYRQLGNT----------QAEIQALRLLHSTLMLLSA-TVP---TVA------------- --------GAHL----------------------------------LSPSL--------- ------------------------------------------------------------ -------LLCSQSLRDLLSVPS-------------------------------------- -------------------------------APSVLHNL--------------------- --------------ALKCVLH--------------------------------------- ------------------------------------------------------------ -----GRVSE----------GVEHY----------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ LDL--------------------------------------------------------- ------------------------------------------------------------ -----LAALH-SED---------------------------------------------- -------------------------------------------------------QHG-- ------------------------------------------------------------ ---------------------------------------------V-----RV------- -----HGEATP-LPRLPQLYLETGAALLMARRPADC------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ MALCN------------------------------------------------------- ---------------------------------------------------------EVI STTLEL-----LPEKLVLE---------------------------DPEDRSQAE----- ------------------------------------------------------------ ---------------------------------------------------TKEVRAEG- ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------E------------------- ------------------------------------------------------------ -----------DKVA--------------MLLWTGA------------------------ ------------------------------------------------------------ ------------------------------------------------------AFLLQG HCHTHL--MDWKKAVTHYTRCINLLVKVCYK----------------------------- ------------KK---------------G------------------------------ -----------FQPQIPS----------A-------DM-VVKQE---------------- ----------------------TDL-----------------CT---------------- -----------------------LQRL--------------------------------- --------------------------------------------KGLSLAGRGISFTQT- ---------------------------------------------------------DRL REALRDLLLSL------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------QAFP------------------------ ----------------------------------------ECVGAGLW------------ ---------------------------------------CGEVLWRL------------- ----------------------------------------------------GRRQEAAA C---------------------W------------------------EKTWSFT-----R Q-----------------------------------G----------------------- ------------------LPLYLQEP---------------------------------- -----------------------------------------------------QSG-PSL DSTKLKRR----------------------------------------IQEL-------- ------------------------------------------------------------ ----------GP-T------------------------ >ENSSLDP00000001852 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------M-----------Y--------------------------- -------------------------------------------------RPTS------- ------LVNKWVQENNELVNKWKQQE-GG------------------------------- -------------------------------------------GVTF------------- ----------------------SRDQNQ-------------------------------- --------SHLRC---------------------------------------------SS SEFYRLLRKI-------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------Q----------------------------------G--- -------------------------------------------VPPLADHTH-------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------LELSVVYNTCVCATA- -QSQFTEAEL--LLTQALRR----------------------------------ALQITG -NDS---VTS--ETPVF---------------WRTV------------------------ ------------------------------------------------------------ ---------LKSVA-NTALNSCVLYLLC-------------------------------- ------------------------------------------------------------ ---------------------------LQW------------------------------ ---------------------------AIWLATCQLKTIQEFK----------------- -------------------------------------------------------EELC- ------------------------------------------------------------ -------------------------SLLETLCGG-------------------------- ----------------------------------------VGDDRRNETWGKSSDVPLLV TDPRKLVELLQ-------------------------------------------I----- ---------------CTSIAQGV--------ERLSEGQC----------------SEALS DLQSASALPAPRAL------------------------------VAYVHLLSGSCLAHMS ------------------------------------------------------------ ------RPQMAL-----QCYRKALETDSCSVCALYQ------------------------ ---------------------------------------------------------SML IYRQLGNT----------QAEIQALRLLHSSLMLPSA-TVP---TVA------------- --------GAHL----------------------------------LSPSL--------- ------------------------------------------------------------ -------LLCSQSLRDLLSVPS-------------------------------------- -------------------------------APSVLHNL--------------------- --------------ALKCVLH--------------------------------------- ------------------------------------------------------------ -----GRVSE----------GVEHY----------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ LDL--------------------------------------------------------- ------------------------------------------------------------ -----LAALH-SED---------------------------------------------- -------------------------------------------------------QHG-- ------------------------------------------------------------ ----------------------------------------------------V------- -----HGEATP-LPRLPQLYLETGAALLMARRPADC------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ MALCN------------------------------------------------------- ---------------------------------------------------------EVI STTLEL-----LPEKLVLE---------------------------DPEDRSQAE----- ------------------------------------------------------------ ---------------------------------------------------TKEVRAEG- ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------E------------------- ------------------------------------------------------------ -----------DMVA--------------MLLWTGA------------------------ ------------------------------------------------------------ ------------------------------------------------------AFLLQG HCHTHL--TDWKQAVTHYTRCINLLVKVRYK----------------------------- ------------KK---------------G------------------------------ -----------FQPQIPS----------A-------DM-VVKQE---------------- ----------------------TDL-----------------CT---------------- -----------------------LQRL--------------------------------- --------------------------------------------KGLSLAGRGISFTQT- ---------------------------------------------------------DRL REALRDLLLSL------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------QAFP------------------------ ----------------------------------------ECVGAGLW------------ ---------------------------------------CGEVLWRL------------- ----------------------------------------------------GRRQEAAA C---------------------W------------------------EKTWSFT-----T Q-S-------SV-----------------------EG----------------------- ------------------LPLYLQEP---------------------------------- -----------------------------------------------------QSG-PSL DSTELRRR----------------------------------------IQEL-------- ------------------------------------------------------------ ----------GP-T------------------------ >ENSLCAP00010060539 MS---------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------DKM-----------Y--------------------------- -------------------------------------------------QPTN------- ------LLNKWVQENNELVNKCKQQE-GG------------------------------- -------------------------------------------GDTL------------- ----------------------SRDQNQ-------------------------------- --------TPLRS---------------------------------------------YS SEFHKLLRKI-------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------Q----------------------------------G--- -------------------------------------------VPPLVNHTH-------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------LELSVVYNACVCSTA- -QSQFTEAEL--LLIQAIQR----------------------------------ALQMTG -DEP---VAS--NRTVF---------------WRTV------------------------ ------------------------------------------------------------ ---------LKSVG-NTTFNTCVRYLLC-------------------------------- ------------------------------------------------------------ ---------------------------LQW------------------------------ ---------------------------AIWLATCQLTIIQELK----------------- -------------------------------------------------------EELS- ------------------------------------------------------------ -------------------------SLFETLCGG-------------------------- ----------------------------------------VGDDKKNEARGKSSDIPLLV TDPRGLVELLQ-------------------------------------------I----- ---------------CTSIIQGA--------ERLSEGQS----------------SEALS ALQTASSLPAPRAL------------------------------LAYVHFLSGSCLAHMS ------------------------------------------------------------ ------RPQMAL-----QCYRKALVTDACCVSALYQ------------------------ ---------------------------------------------------------SML IYRQLGNT----------QAEIQALRLLQSTLMLPSV-TVP---ALA------------- --------TTHL----------------------------------LSPSL--------- ------------------------------------------------------------ -------LLCSQSLSSLLSVPS-------------------------------------- -------------------------------ALSVLHSL--------------------- --------------ALKCVLH--------------------------------------- ------------------------------------------------------------ -----GRVSE----------GVEHY----------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ LDL--------------------------------------------------------- ------------------------------------------------------------ -----LAALH-SED---------------------------------------------- -------------------------------------------------------QHG-- ------------------------------------------------------------ ----------------------------------------------------V------- -----HAEAPA-LPRLPELYLEAGAALLMARRPADC------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ MALCN------------------------------------------------------- ---------------------------------------------------------EVI STTLEL-----LPEKVVLE---------------------------DPEETSEAE----- ------------------------------------------------------------ ---------------------------------------------------TRDMSVDG- ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------E------------------- ------------------------------------------------------------ -----------DRVG--------------MLLWTGA------------------------ ------------------------------------------------------------ ------------------------------------------------------AYLLQG HCHTHL--KDWKQAVTHYTRCINLLVRVRFK----------------------------- ------------KK---------------G------------------------------ -----------FQPQITS----------G-------DM-VVKQG---------------- ----------------------THL-----------------CI---------------- -----------------------LQRL--------------------------------- --------------------------------------------KGLSLAGRGISFTQT- ---------------------------------------------------------DQL KEALRDLLLSL------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------QASP------------------------ ----------------------------------------ECVGAGLW------------ ---------------------------------------CGEVLWRL------------- ----------------------------------------------------GRRQEAAA C---------------------W------------------------EKTWSFT-----T QHH-------SA-----------------------EG----------------------- ------------------LPVYLQEP---------------------------------- -----------------------------------------------------QSG-PLL DSTELRHR----------------------------------------IQEL-------- ------------------------------------------------------------ ----------GP-N------------------------ >ENSSMAP00000017476 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------M-----------Y--------------------------- -------------------------------------------------QPTC------- ------LLNTWVQENNELVKKWK------------------------------------- ------------------------------------------------------------ ----------------------VRSRAQ-------------------------------- --------THLRW---------------------------------------------CS SEFYKLLRKT-------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------Q----------------------------------G--- -------------------------------------------VPPHPDHVH-------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------LELSVVYNACVCATV- -QSQFTEAQL--LLTQAIQR----------------------------------ALQMTS -DDP---VAP--DLPAF---------------WRKV------------------------ ------------------------------------------------------------ ---------LRSVV-NTAFNSCVLDLLC-------------------------------- ------------------------------------------------------------ ---------------------------LQW------------------------------ ---------------------------AMWLATCQLKTIQEFK----------------- ---------------------------------------------------------LS- ------------------------------------------------------------ -------------------------SLVETRGAG-------------------------- ----------------------------------------VGDDKRSEARGKTSDAPLLV TDPRRLVELLQ-------------------------------------------I----- ---------------CTSIAQGA--------ERLSEDQS----------------SEALS GLQKASSLPAPRTL------------------------------VAYVHLLSGSCLSHMN ------------------------------------------------------------ ------CPQMAL-----QCYRKALETDSCCVCALYQ------------------------ ---------------------------------------------------------SML IYRQLGNT----------QAEIQALRLLHSMLMLPSA-TVP---ALA------------- --------GTHL----------------------------------FSPSL--------- ------------------------------------------------------------ -------LLCSQSLSSLLLVPS-------------------------------------- -------------------------------ALSVLHNL--------------------- --------------ALKCALH--------------------------------------- ------------------------------------------------------------ -----GRVSE----------GVEHY----------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ LDL--------------------------------------------------------- ------------------------------------------------------------ -----LAALH-SED---------------------------------------------- -------------------------------------------------------QHG-- ------------------------------------------------------------ ---------------------------------------------V-----RV------- -----YAEAPR-LPRLPELYLEAGAALLMARRSADC------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ MALCN------------------------------------------------------- ---------------------------------------------------------EVI STTLEL-----LPERLVLE---------------------------DPEERSEAE----- ------------------------------------------------------------ ---------------------------------------------------TRDVTAEG- ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------E------------------- ------------------------------------------------------------ -----------DKMA--------------MLLWAGA------------------------ ------------------------------------------------------------ ------------------------------------------------------AYLLQG HCHTHL--KDWKQAVNHFTRCINLLVKVRCK----------------------------- ------------K----------------------------------------------- ----------------------------T-------DM-VVKQG---------------- ----------------------SDL-----------------CV---------------- -----------------------LQRL--------------------------------- --------------------------------------------KGLSLAGRGIAFTQT- ---------------------------------------------------------NHL REALRDLLLSL------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------QAFP------------------------ ----------------------------------------ECVGAGLW------------ ---------------------------------------CGEVLWRL------------- ----------------------------------------------------GRRQEAVA C---------------------W------------------------EKTWSFT-----T Q-S-------SA-----------------------EG----------------------- ------------------LPLYLREP---------------------------------- -----------------------------------------------------QSG-PLL DSKELRHR----------------------------------------IQEL-------- ------------------------------------------------------------ ----------GP-T------------------------ >ENSCGOP00000029237 MS---------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------NKM-----------Y--------------------------- -------------------------------------------------QTHS------- ------LLDIWIQENNELVNKWKQQE-GGDA----------------------------- ------LSR---------------------------------HP---------------- ------------------------SQNQ-------------------------------- --------THLRL---------------------------------------------CS SEFNKLLRKI-------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------Q----------------------------------G--- -------------------------------------------IPPLADHTQ-------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------LELTVVYNACVCSMA- -QSQFSEAQL--LLQQATER----------------------------------VLQMTG -DDP---VAS--DPTGF---------------WRTV------------------------ ------------------------------------------------------------ ---------LKSVG-NTALTPCVLSLLC-------------------------------- ------------------------------------------------------------ ---------------------------LQW------------------------------ ---------------------------AIWLSTCQLKTIQEFQ----------------- -------------------------------------------------------DELF- ------------------------------------------------------------ -------------------------SVFETLSTG-------------------------- ----------------------------------------VWDEGRREPRGKSSDIPLLV MDPRRLVELLQ-------------------------------------------I----- ---------------CTLIAQGA--------ERLSEGRS----------------SEALS GLQSAFSLPAPRTL------------------------------IAYTHLLSGSCLAHMS ------------------------------------------------------------ ------RPQMAL-----QCYRKALETDSQCVCALYQ------------------------ ---------------------------------------------------------SML IYRQLGNT----------QAEIQALRLLHSTLTLPSA-TEP---ALA------------- --------GTHL----------------------------------LSPSL--------- ------------------------------------------------------------ -------LLCSRSLSSLLSVPS-------------------------------------- -------------------------------ALSVLHNL--------------------- --------------ALNCVLH--------------------------------------- ------------------------------------------------------------ -----GRLSE----------GVEYY----------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ LDL--------------------------------------------------------- ------------------------------------------------------------ -----LAALH-SED---------------------------------------------- -------------------------------------------------------QHG-- ------------------------------------------------------------ ----------------------------------------------------V------- -----HAEGPP-LPRLPELYLQAGAALLMARRPADC------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ MALCD------------------------------------------------------- ---------------------------------------------------------EVI TTTLEL-----LPEKVVLE---------------------------EPEEECEAE----- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------TKALSAGGEDEKVRMLLWAGA------------------------ ------------------------------------------------------------ ------------------------------------------------------AYLLQG HCYTHL--KDWKPAVTHYTRCFNLLVKVRFK----------------------------- ------------KR---------------G------------------------------ -----------LQPQIPS----------A-------DV-VGKQG---------------- ----------------------TDL-----------------CI---------------- -----------------------LQRL--------------------------------- --------------------------------------------KGLSLAGRGISFTQT- ---------------------------------------------------------DQL REALRDLQLSM------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------QALP------------------------ ----------------------------------------ECAGAGLW------------ ---------------------------------------CGEVLWRL------------- ----------------------------------------------------GRRREAAA C---------------------W------------------------EKTWSFT-----P Q-P-------SV-----------------------ES----------------------- ------------------LSVYLQEP---------------------------------- -----------------------------------------------------QSG-PLL DSMELRRR----------------------------------------IQEL-------- ------------------------------------------------------------ ----------GP-TSS---------------------A >ENSLCRP00005000898 MS---------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------HKV-----------C--------------------------- -------------------------------------------------QPPS------- ------LLDRWMQENNELVNKWQQKA-GGDA----------------------------- ------VSR--------------------------------------------------- -------------------------DQK-------------------------------- --------THLRS---------------------------------------------CS SEFHKLLQKI-------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------Q----------------------------------G--- -------------------------------------------VPPLADHTQ-------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------LELTVVYNACVCSVA- -QSHFSEAEL--LLIQATER----------------------------------VLQITG -DNP---VAT--DPPVF---------------WKTA------------------------ ------------------------------------------------------------ ---------LKSVA-NTALNSSIQYILC-------------------------------- ------------------------------------------------------------ ---------------------------LQW------------------------------ ---------------------------AIWLATCQLKTIQEFQ----------------- -------------------------------------------------------DELFS LSESL------STGDRVDRRS--------------------------------------- -----------------------GAS---------------------------------- --------------------------------------------------GKSSDIPLLV MDPRRLFELLQ-------------------------------------------I----- ---------------CTYIAQGA--------EKLSEGQS----------------SEALS VLQTASSLPAPKTL------------------------------VAYTHLLSGSCLTHMS ------------------------------------------------------------ ------CPQMAL-----QCYRKALETDSWCVCALYQ------------------------ ---------------------------------------------------------SML IYRQLSNT----------QAEIQALRLLHSTLMLPSA-TEP---ALA------------- --------GTHL----------------------------------LSPSL--------- ------------------------------------------------------------ -------LLCSKPLNSLLSVPS-------------------------------------- -------------------------------ALFVLHSL--------------------- --------------AQKCVIY--------------------------------------- ------------------------------------------------------------ -----GRVSE----------GVECY----------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ LDL--------------------------------------------------------- ------------------------------------------------------------ -----LNTLH-SED---------------------------------------------- -------------------------------------------------------QHG-- ------------------------------------------------------------ ----------------------------------------------------M------- -----HTEVHS-LPRLPELYLEAGAALLMARRPTDC------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ MALCD------------------------------------------------------- ---------------------------------------------------------EVI STTLEL-----LPDKLVLE---------------------------EPEEKCEAE----- ------------------------------------------------------------ ---------------------------------------------------ARPVGEEG- ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------E------------------- ------------------------------------------------------------ -----------DRVG--------------MLLWTGA------------------------ ------------------------------------------------------------ ------------------------------------------------------AYLLQG HCHTNL--KDWKQAVTHYTRCINLLVKVHFK----------------------------- ------------RR---------------G------------------------------ -----------FQPQIPS----------V-------DM-VGKQG---------------- ----------------------TDL-----------------YI---------------- -----------------------LQRL--------------------------------- --------------------------------------------KGLSLAGRGISFSQT- ---------------------------------------------------------DQL REALRDLQLSL------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------QAFP------------------------ ----------------------------------------DCVGAGLW------------ ---------------------------------------CGEVLWRL------------- ----------------------------------------------------GRRREAAA C---------------------W------------------------EKTWSFT-----T Q-S-------SA-----------------------EN----------------------- ------------------LSLYLKEP---------------------------------- -----------------------------------------------------QSG-PLL DSTELRHR----------------------------------------IQGL-------- ------------------------------------------------------------ ----------GP-TLS---------------------A >ENSMALP00000016358 MS---------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------NKI-----------Y--------------------------- -------------------------------------------------HTLS------- ------LFDKWVQENNNLVNKWKQQE-GG------------------------------- -------------------------------------------GDTL------------- ----------------------SRDQSQ-------------------------------- --------THLKW---------------------------------------------CT SEFETLLRKI-------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------Q----------------------------------G--- -------------------------------------------VPPLADHTQ-------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------LEVSVVYNACVCFTA- -QSQFTEAEL--LLKQATER----------------------------------ALQMAG -NFP---VAS--DPPVL---------------WRTV------------------------ ------------------------------------------------------------ ---------LKSVE-NTALNSCVLYLLC-------------------------------- ------------------------------------------------------------ ---------------------------LQW------------------------------ ---------------------------AIWLATCQLKMIEEFQ----------------- -------------------------------------------------------EELT- ------------------------------------------------------------ -------------------------SLVETLPDG-------------------------- ----------------------------------------VWDDRRSKARGKSFDISLLV MEPRRLVELLQ-------------------------------------------I----- ---------------CTSIAQGA--------ERLSEGHS----------------SEALS GLQIASSLPAPRIL------------------------------VAYTHFLSGSCLAHMS ------------------------------------------------------------ ------RPQMAL-----QCYRKALETDFRCVCALYQ------------------------ ---------------------------------------------------------SML IYRQLGNT----------QAEIQALHLLHSTRMLPSA-TEP---ALA------------- --------CTHL----------------------------------LSPSS--------- ------------------------------------------------------------ -------LLRSQSLSSLLSVPS-------------------------------------- -------------------------------ALSVLHNL--------------------- --------------ALKCVLH--------------------------------------- ------------------------------------------------------------ -----GRVSE----------GVEHY----------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ LDL--------------------------------------------------------- ------------------------------------------------------------ -----LAAFH-SED---------------------------------------------- --------------------------------------------------------HQ-- ------------------------------------------------------------ ----------------------------------------------------V------- -----HAEVPP-LPRLTELYLEAGTALLMAQRPADC------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ MALCD------------------------------------------------------- ---------------------------------------------------------EVI STTLEL-----LPEKLILE---------------------------ELEQRN--E----- ------------------------------------------------------------ ---------------------------------------------------IRDVSVEG- ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------E------------------- ------------------------------------------------------------ -----------DRVA--------------MLLWTGA------------------------ ------------------------------------------------------------ ------------------------------------------------------AYLLQG HCQTHL--KDWKQAVIHYTRCINLLMKVWFK----------------------------- ------------KR---------------G------------------------------ -----------FQPQIPS----------A-------DM-IVKEG---------------- ----------------------TYL-----------------SV---------------- -----------------------LQKL--------------------------------- --------------------------------------------KGLSLAGRGISFTQT- ---------------------------------------------------------DQL KEALRDLQLSL------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------QAFP------------------------ ----------------------------------------ECVGAGLW------------ ---------------------------------------CGEVLWRL------------- ----------------------------------------------------GRRRMAAA H---------------------W------------------------EKTWTFS-----A Q-S-------SL-----------------------ES----------------------- ------------------LPVYLQEP---------------------------------- -----------------------------------------------------QSG-PSL DSTELRHR----------------------------------------IQEL-------- ------------------------------------------------------------ ----------GP-I------------------------ >ENSMAMP00000020344 L----------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------NRDQ-------------------------------- --------SHLKW---------------------------------------------CS SEFNKLLRKI-------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------Q----------------------------------GFL- ----------------------LFI-----------------CVPPLADYTQ-------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------LELSVVYNACLCLTA- -QSQFTEAEL--LLTQATER----------------------------------VLQMHG -DDH---VAS--HPHVF---------------WRTI------------------------ ------------------------------------------------------------ ---------FKSIG-NTSLNSRVLYLVC-------------------------------- ------------------------------------------------------------ ---------------------------VQW------------------------------ ---------------------------AMWLATCQLKIIEEFQ----------------- ---------------------------------------------------------LS- ------------------------------------------------------------ -------------------------SLFEALCAG-------------------------- ----------------------------------------VGDDNRSEAKGKSSDLPLLV TDPRRLVQLLQ-------------------------------------------I----- ---------------CTFIAQGA--------EKLNEGHS----------------SQALS AMQKASCLPSPRAL------------------------------VAYTHLLSGSCFAHMS ------------------------------------------------------------ ------RCQMAL-----QCYRKALETDSRCVCALYQ------------------------ ---------------------------------------------------------SVL IYRQLGNT----------QAEIQALRLLHSTLMLPSA-SEP---VLA------------- --------STHL----------------------------------LSPSL--------- ------------------------------------------------------------ -------LLSSQSLSSLLSVPS-------------------------------------- -------------------------------ALSVLHSL--------------------- --------------ALTCVLH--------------------------------------- ------------------------------------------------------------ -----GRASE----------GVEHY----------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ LDL--------------------------------------------------------- ------------------------------------------------------------ -----LAALH-SED---------------------------------------------- -------------------------------------------------------QHGH- ------------------------------------------------------------ --------------------------------NFRTLTNISVVCLP-----QV------- -----HAEVPL-LPRLPELYLEAGTALLMSQRPADC------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ MVLCD------------------------------------------------------- ---------------------------------------------------------EVI STTLEL-----LPEKVLLG---------------------------ELDERNEAE----- ------------------------------------------------------------ ---------------------------------------------------TRDLNGEG- ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------E------------------- ------------------------------------------------------------ -----------DRIQ--------------MLLWTGA------------------------ ------------------------------------------------------------ ------------------------------------------------------AYLLQG HSHTHL--KDWKQAVSHYTRSINLLMKVCVK----------------------------- ------------K----------------------------------------------- ----------------------------S-------DM-VVQQG---------------- ----------------------TYL-----------------CV---------------- -----------------------LQKL--------------------------------- --------------------------------------------KGLSLAGRGVSFTQT- ---------------------------------------------------------DQL KEALRDLQLSL------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------QAFP------------------------ ----------------------------------------ECVAAGLW------------ ---------------------------------------CGEVLWRL------------- ----------------------------------------------------GRKCEAAA I---------------------W------------------------EKTWTFN-----R Q-S-------SA-----------------------ES----------------------- ------------------LPLYLQEP---------------------------------- -----------------------------------------------------QSG-PLL DTTELRHR----------------------------------------IQEL-------- ------------------------------------------------------------ ----------GP-I------------------------ >ENSKMAP00000018287 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------S-----------D--------------------------- -------------------------------------------------KMLS------- ------LLDKWVQENNELANNFK-------VG------N--------------------- -NSEQSC----------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ SEFHKLLRKI-------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------Q----------------------------------G--- -------------------------------------------IPPDAGHAE-------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------LELSVVYNASVCFIA- -QSQIVEAEL--LLQQATER----------------------------------VLQMTG -DDP---DTS--DPLVL---------------WRTV------------------------ ------------------------------------------------------------ ---------LKSVR-KTAFHHHVLYLLS-------------------------------- ------------------------------------------------------------ ---------------------------LQW------------------------------ ---------------------------AIWLTNSYLKTIRDFQ----------------- --------------------------------------------------------EIS- ------------------------------------------------------------ -------------------------ALLETLSGK-------------------------- ----------------------------------------VGDDCRNETKAKFPDVPKLI TDPRRLVELLQ-------------------------------------------I----- ---------------CTIITQGA--------ERLSEGWS----------------SEVLS DLQAASTLPAARAL------------------------------VAYTHLLSGACLAHMN ------------------------------------------------------------ ------RPQMAL-----QCYKTALETDSHCVCALYQ------------------------ ---------------------------------------------------------SIL IYRQLKNS----------QAEIQTLRILHSILLLPSS-SEP---AMA------------- --------GTHL----------------------------------LSPSL--------- ------------------------------------------------------------ -------FLRSQSLSSLLSVPS-------------------------------------- -------------------------------ALSVLHSL--------------------- --------------ALKCVLH--------------------------------------- ------------------------------------------------------------ -----SRASE----------GVEHY----------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ LDL--------------------------------------------------------- ------------------------------------------------------------ -----LAALH-SED---------------------------------------------- -------------------------------------------------------QHR-- ------------------------------------------------------------ ---------------------------------------------I-----GV------- -----HAEVST-LPKLPRLYLEAGAALLMAQRPADC------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ MALCS------------------------------------------------------- ---------------------------------------------------------EVI STTQDL-----LPQKVVLD---------------------------E-SETNAAA----- ------------------------------------------------------------ ---------------------------------------------------TEDVKEEG- ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------E------------------- ------------------------------------------------------------ -----------GGLA--------------MFLWTAA------------------------ ------------------------------------------------------------ ------------------------------------------------------AYLLQG HCFTHM--KDWKQAVTHYTRCINLLVKVHYK----------------------------- ------------NK---------------------------------------------- ------------------------------------DT-DVQQG---------------- ----------------------GDF-----------------CI---------------- -----------------------LQRL--------------------------------- --------------------------------------------KGLSFAGRGISFTQM- ---------------------------------------------------------DRM KEALRDLQHSL------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------QVLP------------------------ ----------------------------------------EGVGAGLW------------ ---------------------------------------CGEVLWRL------------- ----------------------------------------------------SRRCDAAA C---------------------W------------------------EKTWSLP-----T Q-P-------LT-----------------------ET----------------------- ------------------LPVYVQEP---------------------------------- -----------------------------------------------------QTG-PLL DSTELRHR----------------------------------------LHEL-------- ------------------------------------------------------------ ----------HP-V------------------------ >ENSFHEP00000009953 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------M-----------M--------------------------- ----------------------------------------------------S------- ------LLAKWTRENNELAFNCKQQN---DEL------NRD--------------HNNLF SH---------------------------------------------------------- ------------------------------------------------------------ -----------RR---------------------------------------------CS SDFHKLLRKL-------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------Q----------------------------------G--- -------------------------------------------IPPHSDHAQ-------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------LELSVVYNACVCLTA- -LSHFEEAEL--LLTQAAHR----------------------------------VLELAG -EDR---GTS--DPSVL---------------WRAA------------------------ ------------------------------------------------------------ ---------LKSVA-GTALHRHVLSLLC-------------------------------- ------------------------------------------------------------ ---------------------------LQW------------------------------ ---------------------------GIWLAKSCLNPIKEFQ----------------- -------------------------------------------------------EEM-- ------------------------------------------------------------ -------------------------SLLERQGGA-------------------------- ----------------------------------------VWDDCRTEAKEKIPNIPRLV LDPRRLAELLK-------------------------------------------I----- ---------------CTAIVQGA--------ERLNEGWN------------------TLS ALQAAAALPAPRAL------------------------------IAYTHLLSGSCLAHMN ------------------------------------------------------------ ------RPQMAL-----QCFRRALETDPRCACALYQ------------------------ ---------------------------------------------------------STL LYRQLGNV----------QAEIQALRILHSTLLLPPT-TEP---APA------------- --------AGRL----------------------------------LSPSL--------- ------------------------------------------------------------ -------FLCSQSLGSLLSVPS-------------------------------------- -------------------------------ALSVLHSL--------------------- --------------ALKCVIH--------------------------------------- ------------------------------------------------------------ -----DRVSE----------GVENY----------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ LDL--------------------------------------------------------- ------------------------------------------------------------ -----LAALR-SED---------------------------------------------- -------------------------------------------------------QHG-- ------------------------------------------------------------ ---------------------------------------------VTANTLTA------- -----HAVVST-LPKLPRLYLEAAAALLMARRPADC------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ MALCD------------------------------------------------------- ---------------------------------------------------------EVI GTILDL-----LPDKVLLE---------------------------DPEDGSVAE----- ------------------------------------------------------------ ---------------------------------------------------SREEREEA- ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------E------------------- ------------------------------------------------------------ -----------SGLV--------------KLLWAAA------------------------ ------------------------------------------------------------ ------------------------------------------------------AYLLLG HCYAQQ--EDWKQAVTHYTRCFNLLVKVHCK----------------------------- ------------NN---------------A------------------------------ -----------FSPQVSA----------P-------DK-ESNQG---------------- ----------------------VDL-----------------CV---------------- -----------------------LQRL--------------------------------- --------------------------------------------KGISLAGRGISFAQM- ---------------------------------------------------------DRL REALRDLHLGL------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------QALP------------------------ ----------------------------------------EGVSAGQW------------ ---------------------------------------CGEVLWRL------------- ----------------------------------------------------DRRREAAA C---------------------W------------------------EKTWSHT-----C P-P-------LA-----------------------EA----------------------- ------------------LPVYAQEL---------------------------------- -----------------------------------------------------QSG-PLL DPTELRSR----------------------------------------LKEL-------- ------------------------------------------------------------ ----------GP-L------------------------ >ENSXCOP00000022616 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------M-----------I--------------------------- -------------------------------------------------QSTS------- ------LLESWTQENNQLASSCK------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------V-NPSLISWVSCLSL------------------SG--- -------------------------------------------IPPHLDRAQ-------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------LELSVAYNTCVCFTA- -QSQFDEAEL--LLTQSAQR----------------------------------LLQIAG -DDP---GTS--DPSVL---------------WRAA------------------------ ------------------------------------------------------------ ---------LKSVT-GTALRRYVLNLLC-------------------------------- ------------------------------------------------------------ ---------------------------VQW------------------------------ ---------------------------GVWLAKSRLNAMQDFQ----------------- --------------------------------------------------------EM-- ------------------------------------------------------------ -------------------------SLLEAQSGA-------------------------- ----------------------------------------VGNDCMAETKEKIPNIPILV LDPRRLVDLLK-------------------------------------------I----- ---------------CTTIVQGA--------ERLTEGWS------------------VLS ALQAASASPAPRAL------------------------------IAYTHLLSGSCLAHMN ------------------------------------------------------------ ------RPQMAL-----QCYRKALEADPRCVCALYQ------------------------ ---------------------------------------------------------SAL IYRRLENL----------QAEVQALRILHSILLLPSS-TEP---AMA------------- --------AGRL----------------------------------LSPSL--------- ------------------------------------------------------------ -------FLCSQSLSSLLSVPS-------------------------------------- -------------------------------ALSVLHSL--------------------- --------------ALKCVIH--------------------------------------- ------------------------------------------------------------ -----GRVSE----------GVECY----------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ LDL--------------------------------------------------------- ------------------------------------------------------------ -----LAALQ-SED---------------------------------------------- -------------------------------------------------------QHG-- ------------------------------------------------------------ ---------------------------------------------V-----RV------- -----HAAVST-LPKLPRLYLEAGAALVMAQRPADC------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ MALCD------------------------------------------------------- ---------------------------------------------------------EVI GSTLDL-----LPEKVLLE---------------------------DPGDGRVAG----- ------------------------------------------------------------ ---------------------------------------------------SREMTEEA- ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------E------------------- ------------------------------------------------------------ -----------NGLV--------------RLLWTAA------------------------ ------------------------------------------------------------ ------------------------------------------------------AYLLQG HCYSQL--KDWKQAVTHYTRCINLLVKVHYK----------------------------- ------------DT---------------------------------------------- ------------------------------------DK-DAEQG---------------- ----------------------VDL-----------------CV---------------- -----------------------LQRL--------------------------------- --------------------------------------------KGLSLAGRGISFAQI- ---------------------------------------------------------DRL KESLRDLHLSQ------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------QAHP------------------------ ----------------------------------------EGVSARRW------------ ---------------------------------------YGEVLWRL------------- ----------------------------------------------------DRKQEAAA C---------------------W------------------------EQTWSHP-----I P-S-------MTC--LLCFVLWW-----EPQF-FCRA----------------------- ------------------LPVYAQEL---------------------------------- -----------------------------------------------------QSL-PVL DSAKLQQK----------------------------------------LQEP-------- ------------------------------------------------------------ ----------GP-T------------------------ >ENSPLAP00000020315 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------M-----------I--------------------------- -------------------------------------------------QSTS------- ------LLESWTQENNQLASGCKLQD-GQNEP------NRE--------------H-NLF RQ---------------------------------------------------------- ------------------------------------------------------------ -----------RR---------------------------------------------WS SDFHRLLRKI-------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------Q----------------------------------G--- -------------------------------------------IPPHLDRAQ-------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------LELSVVYNTCVCFTA- -QSQFDEAEL--LLTQTAQR----------------------------------LLQIAG -DDP---GTS--DPSVL---------------WRTA------------------------ ------------------------------------------------------------ ---------LKSVT-GTALHRRVLSLLC-------------------------------- ------------------------------------------------------------ ---------------------------LQW------------------------------ ---------------------------GVWLAKSRLTAVQDFQ----------------- -------------------------------------------------------EEV-- ------------------------------------------------------------ -------------------------SLLEAQSGA-------------------------- ----------------------------------------VWNDCRAETKEKISNIPILV LDPRRLVDLLK-------------------------------------------I----- ---------------CTAIVQGA--------ERLTEGWS------------------VLS ALQAASASPAPRAL------------------------------IAYTHLLSGSCLAHMN ------------------------------------------------------------ ------RPQMAL-----QCYRKALETDPRCVCALYQ------------------------ ---------------------------------------------------------SAL IYSRLENS----------QAEIQALRILHSMLLLPST-TEP---AMA------------- --------ADRL----------------------------------LSPSL--------- ------------------------------------------------------------ -------FLCSQSLSSLLSVPS-------------------------------------- -------------------------------ALSVLHSL--------------------- --------------ALKCVIH--------------------------------------- ------------------------------------------------------------ -----SRVSE----------GVECY----------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ LDL--------------------------------------------------------- ------------------------------------------------------------ -----LAALQ-SED---------------------------------------------- -------------------------------------------------------QHG-- ------------------------------------------------------------ ----------------------------------------------------V------- -----HAAVST-LPKLPRLYLEAGAALLMARRPADC------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ MALCD------------------------------------------------------- ---------------------------------------------------------EVI GSTLDL-----LPEKVLLE---------------------------DPVARRVAG----- ------------------------------------------------------------ ---------------------------------------------------SGEVTEEA- ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------E------------------- ------------------------------------------------------------ -----------NGLV--------------RLLWTAA------------------------ ------------------------------------------------------------ ------------------------------------------------------AYLLQG HCYSQL--KDWKQAVTHYTRCINLLVKVHYK----------------------------- ------------DT---------------G------------------------------ -----------FSLQMPC----------A-------DK-DAEQG---------------- ----------------------VDL-----------------CV---------------- -----------------------LQRL--------------------------------- --------------------------------------------KGLSLAGRGISFAQI- ---------------------------------------------------------DRL REALRDLQLSR------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------QAHP------------------------ ----------------------------------------EGVSARRW------------ ---------------------------------------YGEVLWRL------------- ----------------------------------------------------DRKQEAAA C---------------------W------------------------EQTWSNP-----I P-S-------LS-----------------------EA----------------------- ------------------LPVYAQEL---------------------------------- -----------------------------------------------------QSG-PLL DSAELRQK----------------------------------------LQEL-------- ------------------------------------------------------------ ----------GP-T------------------------ >ENSPMEP00000025174 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------M-----------I--------------------------- -------------------------------------------------QSAS------- ------LLESWTQENNQLASGCK--D-GQNEP------NRE--------------H-NLF RQ---------------------------------------------------------- ------------------------------------------------------------ -----------RR---------------------------------------------WS SDFHKLLRKI-------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------Q----------------------------------G--- -------------------------------------------IPPHLDRAQ-------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------LELSVVYNTCVCFTA- -QSQFDEAEL--LLTQTAQR----------------------------------LLQIAG -DDP---GTS--DPSVL---------------WRTA------------------------ ------------------------------------------------------------ ---------LKSVT-GTALHRRVLSLLC-------------------------------- ------------------------------------------------------------ ---------------------------LQW------------------------------ ---------------------------GVWLAKSRLTAVQDFQ----------------- -------------------------------------------------------EEM-- ------------------------------------------------------------ -------------------------SLLEAQSGA-------------------------- ----------------------------------------VWNDCRAETKEKISNIPILV LDPRRLVDLLK-------------------------------------------I----- ---------------CTAIVQGA--------ERLTEGWS------------------VLS ALQAASASPAPRAL------------------------------IAYTHLLSGSCLAHMN ------------------------------------------------------------ ------RPQMAL-----QCYRKALETDPRCVCALYQ------------------------ ---------------------------------------------------------SAL IYSRLENS----------QAEIQALRILHSMLLLPST-TEP---AMA------------- --------AGRL----------------------------------LSPSL--------- ------------------------------------------------------------ -------FLCSQSLSSLLSVPS-------------------------------------- -------------------------------ALSVLHSL--------------------- --------------ALKCVIH--------------------------------------- ------------------------------------------------------------ -----SRVSE----------GVECY----------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ LDL--------------------------------------------------------- ------------------------------------------------------------ -----LAALQ-SED---------------------------------------------- -------------------------------------------------------QHG-- ------------------------------------------------------------ ----------------------------------------------------V------- -----HAVVST-LPKLPRLYLEAGAALLMARRPADC------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ MALCD------------------------------------------------------- ---------------------------------------------------------EVI GSTLDL-----LPEKVLLE---------------------------DPVARRVAG----- ------------------------------------------------------------ ---------------------------------------------------SGEVTEEA- ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------E------------------- ------------------------------------------------------------ -----------NGLV--------------RLLWTAA------------------------ ------------------------------------------------------------ ------------------------------------------------------AYLLQG HCYSQL--KDWKQAVTHYTRCINLLVKVHYK----------------------------- ------------DT---------------G------------------------------ -----------FSLQIPC----------A-------DK-DPEQG---------------- ----------------------VDL-----------------CV---------------- -----------------------LQRL--------------------------------- --------------------------------------------KGLSLAGRGISFAQI- ---------------------------------------------------------DRL REALRDLQLSR------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------QAHP------------------------ ----------------------------------------EGVSARRW------------ ---------------------------------------YGEVLWRL------------- ----------------------------------------------------DRKQEAAA C---------------------W------------------------EQTWSNP-----I P-S-------LS-----------------------EA----------------------- ------------------LPVYAQEL---------------------------------- -----------------------------------------------------QSG-PLL DSAELHQK----------------------------------------LQEL-------- ------------------------------------------------------------ ----------GP-T------------------------ >ENSPFOP00000016681 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------M-----------I--------------------------- -------------------------------------------------QSTS------- ------LLESWTQENNQLASGCK--D-GQNEP------NRE--------------H-NLF RQ---------------------------------------------------------- ------------------------------------------------------------ -----------RR---------------------------------------------WS SDFHRLLRKI-------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------Q----------------------------------G--- -------------------------------------------IPPHLDRAQ-------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------LELSVVYNTCVCFTA- -QSQFDEAEL--LLTQTAQR----------------------------------LLQIAG -DDP---GTS--DPSVL---------------WRTA------------------------ ------------------------------------------------------------ ---------LKSVT-GTALHRRVLSLLC-------------------------------- ------------------------------------------------------------ ---------------------------LQW------------------------------ ---------------------------GVWLAKSRLTAVQDFQ----------------- -------------------------------------------------------EEV-- ------------------------------------------------------------ -------------------------SLLEAQSGA-------------------------- ----------------------------------------VWNDCRAETKEKISNIPILV LDPRRLVDLLK-------------------------------------------I----- ---------------CTAIVQGA--------ERLTEGWS------------------VLS ALQAASASPAPRAL------------------------------IAYTHLLSGSCLAHMN ------------------------------------------------------------ ------RPQMAL-----QCYRKALETDPRCVCALYQ------------------------ ---------------------------------------------------------SAL IYSRLENS----------QAEIQALRILHSMLLLPST-TEP---AMA------------- --------ADRL----------------------------------LSPSL--------- ------------------------------------------------------------ -------FLCSQSLSSLLSVPS-------------------------------------- -------------------------------ALSVLHSL--------------------- --------------ALKCVIH--------------------------------------- ------------------------------------------------------------ -----SRVSE----------GVECY----------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ LDL--------------------------------------------------------- ------------------------------------------------------------ -----LAALQ-SED---------------------------------------------- -------------------------------------------------------QHG-- ------------------------------------------------------------ ----------------------------------------------------V------- -----HAVVST-LPKLPRLYLEAGAALLMARRPADC------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ MALCD------------------------------------------------------- ---------------------------------------------------------EVI GSTLDL-----LPEKVLLE---------------------------DPVARRVAG----- ------------------------------------------------------------ ---------------------------------------------------SGEVTEEA- ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------E------------------- ------------------------------------------------------------ -----------NGLV--------------RLLWTAA------------------------ ------------------------------------------------------------ ------------------------------------------------------AYLLQG HCYSQL--KDWKQAVTHYTRCINLLVKVHYK----------------------------- ------------DT---------------G------------------------------ -----------FSLQIPC----------A-------DK-DPEQG---------------- ----------------------VDL-----------------CV---------------- -----------------------LQRL--------------------------------- --------------------------------------------KGLSLAGRGISFAQI- ---------------------------------------------------------DRL REALRDLQLSR------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------QAHP------------------------ ----------------------------------------EGVSARRW------------ ---------------------------------------YGEVLWRL------------- ----------------------------------------------------DRKQEAAA C---------------------W------------------------EQTWSNP-----I P-S-------LS-----------------------EA----------------------- ------------------LPVYAQEL---------------------------------- -----------------------------------------------------QSG-PLL DSAELRQK----------------------------------------LQEL-------- ------------------------------------------------------------ ----------GP-T------------------------ >ENSXMAP00000007520 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------M-----------I--------------------------- -------------------------------------------------QSTS------- ------LLESWTQENNQLASSCKQQD-GQDAP------NRE--------------H-NLF RQ---------------------------------------------------------- ------------------------------------------------------------ -----------RR---------------------------------------------WS SDFHKLLRKI-------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------Q----------------------------------G--- -------------------------------------------IPPHLDRAQ-------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------LELSVAYNTCVCFTA- -QSQFDEAEL--LLTQSAQR----------------------------------LLQIAG -DDP---GTS--DPSVL---------------WREA------------------------ ------------------------------------------------------------ ---------LKSVT-GAALRRDVLNLLC-------------------------------- ------------------------------------------------------------ ---------------------------LQW------------------------------ ---------------------------GVWLAKSRLNAMQDFQ----------------- -------------------------------------------------------EEM-- ------------------------------------------------------------ -------------------------SLLEAQSGA-------------------------- ----------------------------------------VGNDCRAETKENIPNIPILV LDPRRLVDLLK-------------------------------------------I----- ---------------CTTIVQGA--------ERLTEGWS------------------VLS ALQAASASPAPRAL------------------------------IAYTHLLSGSCLAHMN ------------------------------------------------------------ ------RPQMAL-----QCYRKALEADPRCVCALYQ------------------------ ---------------------------------------------------------SAL IYRRLENL----------QAEIQALRILHSILLLPSS-TEP---AMA------------- --------TGRL----------------------------------LSPSL--------- ------------------------------------------------------------ -------FLCSQSLSSLLSVPS-------------------------------------- -------------------------------ALSVLHSL--------------------- --------------ALKCVIH--------------------------------------- ------------------------------------------------------------ -----GRVSE----------GVECY----------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ LDL--------------------------------------------------------- ------------------------------------------------------------ -----LAALQ-SED---------------------------------------------- -------------------------------------------------------QHG-- ------------------------------------------------------------ ----------------------------------------------------V------- -----HAAVST-LPKLPRLYLEAGAALLMAQRPADC------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ MALCD------------------------------------------------------- ---------------------------------------------------------EVI GSTLDL-----LPDKVLLE---------------------------DPGDGRVAG----- ------------------------------------------------------------ ---------------------------------------------------SREMTEEA- ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------E------------------- ------------------------------------------------------------ -----------NGLV--------------RLLWTAV------------------------ ------------------------------------------------------------ ------------------------------------------------------AYLLQG HCYSQL--KDWKQAVTHYTRCINLLVKVHCK----------------------------- ------------DT---------------G------------------------------ -----------FPLQTPC----------T-------DK-DAEQG---------------- ----------------------VDL-----------------CV---------------- -----------------------LQRL--------------------------------- --------------------------------------------KGLSLAGRGISFAQI- ---------------------------------------------------------DRL KESLRDLHLSQ------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------QAHP------------------------ ----------------------------------------EGVSARRW------------ ---------------------------------------YGEVLWRL------------- ----------------------------------------------------DRKQEAAA C---------------------W------------------------EQTWSHP-----I P-S-------LS-----------------------EA----------------------- ------------------LPVYAQEL---------------------------------- -----------------------------------------------------QSL-PVL DSAKLQQK----------------------------------------LQEP-------- ------------------------------------------------------------ ----------GP-T------------------------ >ENSMMOP00000023825 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------Q-----------V--------------------------- -------------------------------------------------MTLS------- ------LNDEW----------------------------RE--------MR---HH---- ------------------------------------------------------------ ------------------------AQNK-------------------------------- --------NLLRC---------------------------------------------CS SEFHKLLRIV-------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------Q----------------------------------G--- -------------------------------------------IPPLADHTQ-------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------LELSVVYNACLCSVA- -CAQFSEAEL--LLKKATER----------------------------------VLQMTG -DDP---LDS--DPLLF---------------WRTI------------------------ ------------------------------------------------------------ ---------IKSVE-NTAMKSSVQYIFG-------------------------------- ------------------------------------------------------------ ---------------------------LQW------------------------------ ---------------------------AIWLADCKLTTIQECQ----------------- -------------------------------------------------------HELF- ------------------------------------------------------------ -------------------------TLCETLSAG-------------------------- ----------------------------------------V--DQRRQARGKSCDVPRLV MDPGRLLKLLQ-------------------------------------------I----- ---------------CTLITQGA--------ERLSEGRS----------------SEALS GLQTASSLPAPTTL------------------------------VAYTHLISGSCLALMN ------------------------------------------------------------ ------CPQMAL-----QCYRKVLETDPRCVCALYQ------------------------ ---------------------------------------------------------SIL VYRKLGNT----------QAEIQALRLLHSTLMLPSA-TEP---SLP------------- --------GTPL----------------------------------LCPSS--------- ------------------------------------------------------------ -------LLQSQSLNSLLSVPS-------------------------------------- -------------------------------ALSVLHSL--------------------- --------------AQKCVLH--------------------------------------- ------------------------------------------------------------ -----GRLSE----------GVEYY----------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ LDL--------------------------------------------------------- ------------------------------------------------------------ -----LATVH-SED---------------------------------------------- -------------------------------------------------------QHG-- ------------------------------------------------------------ ----------------------------------------------------V------- -----HVEVPA-LPRLPELYLEAGAALLMDQRPADC------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ MVLCE------------------------------------------------------- ---------------------------------------------------------EVI SSTLEL-----LPERLVLE---------------------------EPEDTYETE----- ------------------------------------------------------------ ---------------------------------------------------AGAVGAGG- ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------D------------------- ------------------------------------------------------------ -----------QRVG--------------MLFWAGA------------------------ ------------------------------------------------------------ ------------------------------------------------------AYLLQG HCYTQL--KDWKQAVAHYTGCINLLVKVRFK----------------------------- ------------KK---------------GK----------------------------T CSFL------ALHSQ--------------------------------------------- ------------------------------------------------------------ --------------------------L--------------------------------- --------------------------------------------KGLSLAGRGISFTQT- ---------------------------------------------------------EQL REALRDLQLSL------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------QASP------------------------ ----------------------------------------DCVAAGLW------------ ---------------------------------------CGEVLWRL------------- ----------------------------------------------------GRRQEAAA C---------------------W------------------------ENTWSCN-----T Q-S-------S------------------------ES----------------------- ------------------LSLYLQEP---------------------------------- -----------------------------------------------------QSG-PLL DSMELRHR----------------------------------------IKEL-------- ------------------------------------------------------------ ----------SP-PCQRRKLQKQNTPSLNNKDNDIWHL >ENSCSEP00000021079 MCP-------------------PVAGLP-------------------------------- ------------------------------------------------------------ ----------------------DQVSHLAVYFLLASP----------------------- ---------------------ETREILKT------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -------------ENNALVQKLK---------------------------RVESSH---- ---------------------------------------------SL------------- ----------------------SRDQNQ-------------------------------- --------NHLRW---------------------------------------------CS LEFDKLLSKV-------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------Q----------------------------------G--- -------------------------------------------VPPLADDTH-------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------LELSVAYNTCLCFTA- -QSRFTDSVL--ILSQSIQR----------------------------------VLQTTD -EAPQ-SVAS--DLPAF---------------WKKV------------------------ ------------------------------------------------------------ ---------LKSVR-NTTLNNFVLNLLC-------------------------------- ------------------------------------------------------------ ---------------------------SQW------------------------------ ---------------------------LIWLATCKLKAVQEFE----------------- -------------------------------------------------------EDLY- ------------------------------------------------------------ -------------------------SLTKTLCAGAEND---------------------- --------MG-----------CKKV---------EKFLYT----------------PLLV MEPRRLAELLQ-------------------------------------------I----- ---------------WTSVAQGA--------ERLAEGQN----------------LEALS GLQKASSLPAPRIL------------------------------LAYIHHLCGCCFVQMN ------------------------------------------------------------ ------CPQMAL-----QCYKKALETDYSCVCALYQ------------------------ ---------------------------------------------------------SVL IYRQLGNT----------QAEIQALCLLYSTLMLPPP-VVP---PLA------------- --------DAQL----------------------------------LSPSL--------- ------------------------------------------------------------ -------LLHSQSFDTLHFVPS-------------------------------------- -------------------------------ALSVLHTL--------------------- --------------ALKCVLH--------------------------------------- ------------------------------------------------------------ -----NRLAE----------GVDHY----------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ LDL--------------------------------------------------------- ------------------------------------------------------------ -----LATLQ-SED---------------------------------------------- -------------------------------------------------------QQP-- ------------------------------------------------------------ ----------------------------------------------------I------- -----NSKVPD-YPRLPELYLEAGAALLMACRPADC------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ MALCN------------------------------------------------------- ---------------------------------------------------------EVI NTTLEL-----LPQRLVLE---------------------------DPEKRSHGE----- ------------------------------------------------------------ ---------------------------------------------------DND--DNG- ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------E------------------- ------------------------------------------------------------ -----------DKAA--------------VLFWTGT------------------------ ------------------------------------------------------------ ------------------------------------------------------AYLLQG HCYSQL--KDWKQAVTHYTRCINLLVKVCVK----------------------------- ------------TK---------------G------------------------------ -----------SQPQVPG----------P-------GV-VVKPG---------------- ----------------------THV-----------------CV---------------- -----------------------LQRL--------------------------------- --------------------------------------------KGLSLVGRGVSFTLT- ---------------------------------------------------------DHL QEALRDLQLSL------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------HAFP------------------------ ----------------------------------------ECVVAGLW------------ ---------------------------------------CGEVLWKL------------- ----------------------------------------------------GRRREAAA C---------------------W------------------------EKTWSYS-----T Q-S-------TV-----------------------DD----------------------- ------------------LPLYLQEP---------------------------------- -----------------------------------------------------QLG-SLL DSTEIRKR----------------------------------------IQEL-------- ------------------------------------------------------------ ----------GP-TRS---------------------T >ENSTNIP00000000540 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------M-----------H--------------------------- -------------------------------------------------KQTS------- ------FINGWIQDNNDLANKCKRFK-GGVV----------------------------- ------------------------------------------------------------ -------------------------QVQ-------------------------------- --------NHLKE---------------------------------------------CS FEFHKLLRII-------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------Q----------------------------------G--- -------------------------------------------IPPLVEHAD-------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------LELSVVYNACLCSVA- -HHQFPEAEL--VLRRAADR----------------------------------VLQMTG -ADP---EIS--D-TVF---------------WKTV------------------------ ------------------------------------------------------------ ---------FELAR-STAITSRVLYVAG-------------------------------- ------------------------------------------------------------ ---------------------------VQW------------------------------ ---------------------------AVWLASSQLKTIEEFQ----------------- -------------------------------------------------------DELF- ------------------------------------------------------------ -------------------------TLSEIL----------------------------- ---------AAEDGNEHRKNDCA----------------------------KSSTTPLMV MDPRRLFELLA-------------------------------------------I----- ---------------CTLIAQGA--------EMLNEGQS----------------SEALA VLQRASSLPAPRKL------------------------------VAHTHMLSGACFTLMN ------------------------------------------------------------ ------CPQMAL-----HCYKEALETDPQCVCALYQ------------------------ ---------------------------------------------------------SIL VYRTLGNL----------QAELQALRLLHSMML--ST-AEA---SPA------------- --------DAPL----------------------------------LSPSS--------- ------------------------------------------------------------ -------LLPSRSLKSLLSVPS-------------------------------------- -------------------------------ALSLLHCL--------------------- --------------AQKCVLQ--------------------------------------- ------------------------------------------------------------ -----GRVLE----------GVEHF----------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ LDL--------------------------------------------------------- ------------------------------------------------------------ -----LASLH-SGE---------------------------------------------- -------------------------------------------------------QYA-- ------------------------------------------------------------ ----------------------------------------------------M------- -----QAEVSP-LPRLPEFYLEAGAALLMAQRPADC------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ MALCD------------------------------------------------------- ---------------------------------------------------------EVI GSTLEL-----LPKKLVLE---------------------------EEE----------- ------------------------------------------------------------ ----------------------------------------------------------GK ------------------------------------------------------------ -----------------------------------GDTEAGAE----------------- ------------------------------------ATQED------------------- ------------------------------------------------------------ -----------ERMR--------------MLLWTGA------------------------ ------------------------------------------------------------ ------------------------------------------------------AYLLQG HCHTHL--KDWKQAVTHYTRCINLLVRVLFK----------------------------- ------------QR---------------G------------------------------ -----------CPPQIPD----------A-------DV-DAKCG---------------- ----------------------THL-----------------SV---------------- -----------------------LKRL--------------------------------- --------------------------------------------KGLSLAGRGISFLQT- ---------------------------------------------------------EQL REALRDLQLSL------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------HALP------------------------ ----------------------------------------GCVGAGLW------------ ---------------------------------------RGEVLWRL------------- ----------------------------------------------------GRKQEAAA C---------------------W------------------------EETWSFA-----T R-S-------PSEKSFLCT----------------------------------------- ----------------------LLEP---------------------------------- -----------------------------------------------------QSG-PVL DSEELRHR----------------------------------------VKEL-------- ------------------------------------------------------------ ----------IP-P------------------------ >ENSELUP00000011012 MA---------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------------VM S-------------------Y-----------E--------------------------- -------------------------------------------------SDTC------- ------LLERWTEENNAIVNKWKQHN-DK------------------------------- -------------------------------------------GDLV------------- ----------------------TREQGS-------------------------------- --------RLLKS---------------------------------------------CY EASLQLLQMI-------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------Q----------------------------------G--- -------------------------------------------VPAVHDRVQ-------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------LELAVVYNFCMFSFS- -QTQLPEAEI--LLSHSLER----------------------------------ALGAEG CDGP---PPS--NPPVF---------------WRVV------------------------ ------------------------------------------------------------ ---------LESLGPMSSLCSSLLQLLC-------------------------------- ------------------------------------------------------------ ---------------------------VQW------------------------------ ---------------------------AFWLSTVRLGHILELQ----------------- -------------------------------------------------------GELL- ------------------------------------------------------------ -------------------------SLFEGL------GLD-------------------- --ERDDTRKAGEEGLE-----------------------------------TSAVRPALV IHPRELKDLLH-------------------------------------------I----- ---------------CTVIAQGA--------ELLCEGRW----------------SEALT ILQRDPSPLTPRDL------------------------------LAQIHTLTGLCLSSMG ------------------------------------------------------------ ------HPHSAL-----QCFRKALETDVRCVSALQQ------------------------ ---------------------------------------------------------SVL VYRQLGNT----------QAEIQALRLLHSVLMLPPA-SQP---TVA------------- --------SGPL----------------------------------IAPAI--------- ------------------------------------------------------------ -------LLPGQSLSSLLSVPS-------------------------------------- -------------------------------ALSVLHCL--------------------- --------------AQKCVLH--------------------------------------- ------------------------------------------------------------ -----GSVSE----------GVEHY----------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ LDL--------------------------------------------------------- ------------------------------------------------------------ -----LAALQ-SDQ---------------------------------------------- -------------------------------------------------------QMS-- ------------------------------------------------------------ ---------------------------------------------------QV------- -----LSEAPS-LPRLPELYLETGSSLLMAQRPDDC------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ LVLCD------------------------------------------------------- ---------------------------------------------------------EVI SKTVDL-----LPERLRLE---------------------------EPLE---------- ------------------------------------------------------------ ----------------------------------------------------DPMEESG- ------------------------------------------------------------ -----------------------------------HDS---------------------- ----------------------------------------A------------------- ------------------------------------------------------------ -----------DRLG--------------LVLWCGA------------------------ ------------------------------------------------------------ ------------------------------------------------------AYLLQA HCYSHL--KDWKQAVTLYTRCISLLMKV-------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------CVVQ-------------- ----------TAGCVKQGLGVRNLQRL--------------------------------- --------------------------------------------KGLALAGRGISFIHR- ---------------------------------------------------------DQN REALRDLQLSL------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------QAAS------------------------ ----------------------------------------GCASAGLW------------ ---------------------------------------LTEVLWRL------------- ----------------------------------------------------GRRREAVA C---------------------W------------------------EENQSSS-----S P-P-------LL-----------------------QD----------------------- ------------------APLYLLDP---------------------------------- -----------------------------------------------------QTG-PSL DPADLRGR----------------------------------------MEEFTKTQ---- ------------------------------------------------------------ ------QHQGLP-L------------------------ >ENSCPRP00005011872 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------M-----------AAMV------------------------ ----------------------PP----------------------------------VK LKWLEHLNSSWITEDSESIATREGVS----VLYSKLVSNKEVVPLPQQVLCLKGPQLPDF ER--ESLSSD---------------------EQDHYLDALLSSQLALAKMVCSDSPFAGA LRKRLLVLQRVFYALSNKYHDKGKVKQQQHSPESSSGSTDVHSVSERPRSSTDALIEMGV RTGLSLLFALLRQSWMMPASGPGLNLCNDVIHTAIEVVSSLPPLSLANESKIPPMGLDCL SQVTTFLKGV--TIPNSGADTLGRRLASELLLGLAAQRGSLRYLLEWIEMALGASAVVNT MEKNKMLQSQEGMISFDCFMNILMQMRRSLGSSADRSQWREPTRTSDGLCSLYEAALCLF EEVCRMASDYSRTCASPDSIQTGDAPIVSETCEVYVWGSNSSHQLVEGTQEKILQPKL-- APSFSDAQTIEAGQYCTFVISTDGSVRACGKGSYGRLGLGDSNNQSTLKKLTFEPHRSIK KVSSSKGSDGHTLAFTTEGEVFSWGDGDYGKLGHGNSST--------------------- -------QKYP-------KLIQ----------------------------------GPLQ GKVVVCVSAGYRHSAAVTEDGELYTWGEGDFGRLGHGDSNSRNIPTLVKDISNVGEVSCG SSHTIALSKDGRTVWSFGGGDNGKLGHGDTNRVYKPKVIEALQGMFIRKVCAGSQSSLAL TSTGQVYAWGCGACLGCGSSEATALRPKLIEELAATRIVDISIGDSHCLALSHDNEVYAW GNNSMGQCGQGNSTGPITKPKKVSGLDGVAIQQISAGTSHSLAWTALPRDRQVVAWHRPY CVDLEESTFSHLRSFLERYCDKINSDIPPLPFPSSREHHSFLK-LCLKLLSNHLALALAG GVATSILGRQAGPLRNLLFR--------------LMDSSVPDEIQEV-------VIETLS VGATMLLPPLRERMELL-----HSLLPQGPDRWESLSKGQRMQLDIILTSLQDHTHVASL LGYSSPSDTTDISSLCIGYGNLSDQTYGVQSSHPDTHLAEILMKTLLRNLGFYTDQAFGE LEKNSDKFLLGTSSSENSQPAHLHELLCSLQKQLLAYCHINSVSENSSSVALLHKHLQLL LPHATDIYSRSATLLKESSWNGSVGEKLRDVIYVSAAGSMLCQIVNSLLLLPVSVARPLL SYLLDLLPPLDRLNRLLPAAALLEDQELQWPLHGGPELIDPAGVPLPQPAQSWVWLVDLE RTVALLIGRCLGGMLQGPPVSPEEQDTAYWLKTPLFSDGVEMDIPHLEKCMSSLLEVALS GNEEQKPFDYKLRPEIAVYVDLALGCTKEPARSLWISMQDYAVSKDWDTATLSNETLLDT VSRFVLASLLKHTNLL---------SQAC----------GES-RYQPGKALAEVYRCVYK VRSRLLACKNMELIQTRSSSRDR--WMSENLESA---DTDPQEHSFTRTIDEEAEMEEQA ERDREEGHPEQEDEEEEREHEVMTAGTREVARSRDRDRMNVG------TGTRVDDQPTQT QQERRISTDLP-----------------------------EGQ-------DVY-TAACNS V--------IHR---CALLILGVSPVIEELQKRREEGQLQQPSTSTPEGIGLMTRSESLT AESRSAHTSSSYRLIKSRSESDLSQPESDEEGYSLSGRRNVDLDLASSHRKKGAIYSQVE PLSDSWARLKHSRDWLYSSSYSFVESDFDLSKSLGVHTLIENVVSFVSGDVGNSPGFKEP EESMSTSPQASIIAMEQQQLRAELRLE-----ALHQILVLLSGMEEKGSVPLMGTHQGSG FQSSSLLTSVRLQFLAGCFGLGTVGHAGSKGESVRLHHYQDGIRAAKRSIQIEIQVAVHK IYQQLSATLERALQANKHHIEAQQRLLLVTVFALSVH-YQPVDVSLAISTGLLNVLSQLC GTDTMLGQPLQLLPKTGISQLSTALKVASTRLLQILAITTGTYADKLSPKVVQSLLDLLC SQLKNLLSQAGVMLMASFGEGEVEEVEEDSKRIDSNGENEKRDFRAVLRKQHAAELHLGD FLVFLRRVVSSKAIQSKMASPKWTEVLLNIASQKCCSGVPLVGNLRTRLLALHVLEAVLP ACESGVEDDQMAQVVERLFSLLSDCMWETP-IAQAKHAIQIKEREQEMKLQKQGESEEED ENLPIQEVSFDPEKAQCCIVENGQILTHGSGGKGYGLASTGVTSGCYQWKFFIVKENRGN EGTCVGVSRWPVHDFNHRTTSDMWLYRAYSGNLYHNGEQTLTLSSFTQGDYITCVLDMEA RTISFGKNAEEPKLAFEDVDAAELYPCVMFYSSNPGEKVKICEMQMRGTPRDLLPGDPIC SPVAAVLAEATIQLIRILHRTDRWTHCINKKMMERLHKIKMCLKEAGQKLKKSRSVQSRE ESEMREEKETKEEEKSKHSRHGLADLSELQLKTLCVEVWPVLAVIGGVDAGLRVGGRCVH KQTGRHATLLGVVKEGSTSAKVQWDEAEITISDTPLYNLEPCEPLPFDVARFRGLTATVL LDLTYLTGIHEDMGKQSTKRHEKKHRHESEDKGETDQKTECDTGSDMRSVLSADDVKGHS TTSSKSENEMASFSLESTTLGMESQHQPTEGKRKNHEHTPRNHDVVQSEIRAVQLSYLYL GAMKSLSVLL-SCSKYAELLLIPKVLAENGHNSDCASSPVVHEDVEMRAALQFLMRHMVK RAVMRSPIKRALGLADLERAQAMIYKLVVHGLLEDQFGARIKQEVDQQAEESDQAQQAQT PVTTSPSASSTTSFMSSSLEDTTTATTPVTDTETVPASESPGVMPLSLLRQMFSSYPTTT VLPTRRAQTPPISSLPTSPSDEVGRRQSLTSPDSQT---------V-----RPTNRTALS DPSSRLSTSPP-PPAIAVPLLEMGFSLRQIAKAMEATGARGEADAQNITVLAMWMIEHPG NEDDEEPQSEGTADSQHGTIVSGTSGKSSDQCYLQSPGDIPSADATEMEEGFSESPDNMD HTENAASGSGPPSRSRSAVTRRHKFDLAARTLLARAAGLYRSVQAHRNQSRREGISLQQD PGALYDFNLDEELEIDLDDEAMEAMFGQDLASDNDILGMWIPEVLDWPTWHVCESEDREE VVVCELCESSVVSFNQHMKRNHPGCGRSANRQGYRSNGSYVDGWFGGECGSGNPYYLLCG SCREKYLALKSKSKTSSSERYKGQAPDLIGKQDSVYEEDWDMLDVDEDEKLTGEEEFELL AGPLGLNDRRIVPEPVQFPDSDPLGASVAMVTATNSME--------ETLMQIGCHGSIEK CSSGRITLGEQAAALVNPHDRVMALRRVTAAAQVLLARTMVMRALSLLSVSGSSCSLAAG LESLGLTDIRTLVRLMCLAAAGRAGLSTSSST------------ISSTTERSRGIHSKTS KPISCLAYLSTAVGCLASNTPSAAKLLVQLCTQNLISAATGVNLTTVDDPIQRKFLPSFL RGIAEENKLVTSPNFVVTQALVALLADKGAKLRPNYDKAEIEKKGPLELANALAACCLSS RLSSQHRQWAAQQLVRTLAAHDRDNQTSPQTLADMGGDLRKCSFIKLEAHQNRVMSCVWC NKKGLLATNGNDGTIRVWNVTKKQYSLQQTCVFNKFENDSEDSLGSPTDSGLSLVCWSIS GKYLA---GALEKMVNIWQVNGGKGLLDLQPHWVSALAWPEEVPIATWTGDNPEVLLVGR MDGSLGLIEVVDVSTMHRLELEHCYRKDVSVTCLAWFSEDRPFAVGYSDGKLLIGTKEPL EKGGIVLIDAHKDTIVSMKWDPTGKILMTCAKEETVKLWGYVGGCWRCLHSLSHPAIVNG IAWCALPGKGTKLQLLLATGCHNGLVCV---------------------------WT--- --------VPQ-DMTMMLQSSLGCSEGWWDQET----TGRDGYRKAAEAKCIFQLRGHIT -----PVRTVAFSPD--GL-----AL-VSGGLGGLMNIWSLRDGSVLQSVVIGSGAIQTA VWIPDIGVAACSNRS-------KDVLVVN-------------CTSEWISSNHVLATCRTA LKQQGVLGLNMAPCMRAF-----LERLPIMLQEQYAYEKPHVVCGDQLVHSPYMQCLASL AVGLHLDQLLCSPPVPPHHQNFLPDPSTWNPTEWAWLECFSTTIKAAEALAKGAQFPESF TVPDLEPVPEEELTLLMDNSKWINGMDEQIMSWATSRPEDWHLGGKCDVYLWGAGRHGQL AEAGRNVMIPVSAPSFSQAQQVICGQNCTFVIQANGTVLACGEGSYGRLGQGNSDDLHVL TVISALQGFVVTQLVTSCGSDGHSMALTESGEVFSWGDGDYGKLGHGNSDRQRRPRQIEA LQGEEVVQMSCGFKHSAVVTADGKLFTFGNGDYGRLGLGNTSNKKLPERVTALEGYQIGQ VACGLNHTVAVSTDGSMVWAFGDGDYGKLGLGNSTAKSSPQKVDVLCGLGIKKVACGTQF SVALTKDGHVYTFGQDRLIGLPEGRARNHNRPQQVPVLSGIFIEDIAVGAEHTLALSSAG DVYAWGSNSEGQLGLGHTNHVREPTLITVLQGKNIRQISAGRCHSAAWTAPPVPPRAPGV SVPLQLGFPDAIPPQYGTLKEVSIHTVRARLRLLYHFSDLMYSSWRLLNLSPNNQNSTSH YNAGTWGIVQGQLRPLLAPRVYTLPMVRSIGKTMVQGKNYGPQITVKRISTRGRKCKPIF VQIARQVVKLNASDLRLPSRA-WKVKLVGEGADDAGGVFDDTITEMCQELETGVVDLLIP S-P----NASAE---------VGYNRD---RFLFNPSACLDEHLMQFKFLGILMGVAIRT KKPLDLHLAPMVWKQLCCIPLILEDLEEVDLLYVQTLNSILHIEDSGITEENFHEMIPLD SFVGQSADGKMVPIIPGGNSIPLTFSNRKEYVERAIEYRLHEMDRQVAAVREGMSWIVPV PLLSLLTAKQLEQMVCGMPEISVEVLKKVVRYREVDEQHQLVQWFWHTLEEFSNEERVLF MRFVSGRSRLPANTADISQRFQIMKVDRPYDSLPTSQTCFFQLRLPPYSSQLIMAERLRY AINNCRKNTEGS-L------------------------