>ENSDORP00000015791 -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ----------M-----------SxxIx----------------------- ---------x---------------xxxxx-------------------- xTS-------------FLDLWREKNDQLVRQAKxVV-QD----------- -------------------------------------------------- ------------xQLS---------------------------------- ----LRRQ----------------------------------------QL AQD---------------------------------------------TL EGLRKLLWGL---------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ---------------------Q---------------------------- ------G------------------------------------------- ---LPATVPVLP-------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- --------------------------------------------LELTVT CNFIILRVS--LAQGFTEDLAQDIQRSLKR-------------------- --------------VLETQE-HLE---PRxQQSLREL------------- --WESV-------------------------------------------- -------------------------------------------------L HASSLLPELLSALHLLAG-------------------------------- -------------------------------------------------- -------------------------------------LQA---------- -----------------------------------------------ALW LSTDHLGDLAIL-------------------------------------- -------------------------------------LQTLNG------- ---------------SQ--------G---RTS------------------ --EDLLL-----LFKSWNPPVEK--------------------------- -------------------------------------------------- -------------SDGPLTLQNAQSLRAVLL------------------- ------------------------T--------------------AFAYQ QGL--------QELITGNL----------------PRALRNLHEAASGLC TRPV------------------------------LVQVYTALGTCLRKME -------------------------------------------------- ----------------NPQRAL-----LYLIEALKVGTDCSLPLLE---- -------------------------------------------------- ---------------------------ASRLYRQLGDT----------SA ELESLELLVEALSVI----RS---SKS---------------------PQ LL----------------------------------IEAEL--------- -------------------------------------------------- -----------------LLPQPDQASPLHCVT------------------ -------------------------------------------------- -PSQAKHLL-----------------------------------ASRCLQ I------------------------------------------------- -------------------------------------------------- -----GREED----------AAEHY------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ----------------------------------------LDL------- -------------------------------------------------- -------------------------------------------------- ---------------LALLL-DGS-------------------------- -------------------------------------------------- -------------------------xPR---------------------- -------------------------------------------------- -----------------------------------F------S------- -----LLPCPP-GPCVPEVFLETAAALIQAGRAQDA-------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ----------------------------------------FTVCE----- -------------------------------------------------- -------------------------------------------------- -------ELLSRTSSL-----LPKMSQLR--------------------- ------EGARx--------------------------------------- -------------------------------------------------- -------------------------------------GS----------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- K------------------------------------------------- -----------------------------------------ELPY----- ---------CQLWVSA---------------------------------- -------------------------------------------------- -------------------------------------------------- ----THLLQGQAWVHL--KAPKEAVSEFSRCLELLFCT------------ ----------------------------xxx-DK---------------E Q----------------------------------------------xx- -------------------xxxxxxx------------------------ ------------xxA------------------A---------------- -----------------------LQQL----------------------- -------------------------------------------------- ----RVAALISRGLVWVAS------------------------------- ---------------------------NQDTKALKDFLLSV--------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- --QIFP-------------------------------------------- --------------------GSRDASYY---------------------- -----------------------------LLQTLRRL------------- -------------------------------------------------- --DRKDDATAL---------------------W----------------- -------QRLEAQT-----EL-T----xxEAT----------R------- ------S-----------------------------------------LP LYLETY-------------------------------------------- -------------------------------------------LSWIHPT DCETFLEE----------------------------------------FR TSL----------------------------------------------- ---------------------------xxPHD-Q---------------- -------- >ENSAMEP00000016351 -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ----------A-----------Sxxx------------------------ ----------------------xx-xxxxx-------------------- xAS-------------CLDLWREKNDQLVRQVK-Vx-QD----------- -------------------------------------------------- ------------xRLS---------------------------------- ----LRRQ----------------------------------------QL AQD---------------------------------------------AL EGFRGLLHSL---------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ---------------------R---------------------------- ------G------------------------------------------- ---LPAAVPVLP-------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- --------------------------------------------LELTVT CNFITLRAS--LAQGFTEDQAQDIQQGLER-------------------- --------------VLETQE-QLG---PRxxxGLRGL------------- --WDSI-------------------------------------------- -------------------------------------------------F GYSSxLLELLPALHLLAG-------------------------------- -------------------------------------------------- -------------------------------------LQA---------- -----------------------------------------------ALW LSTDSLGDLTFL-------------------------------------- -------------------------------------LQTLNG------- ---------------NQ--------S---EAS------------------ --ENLLL-----LLKTWSPPAEE--------------------------- -------------------------------------------------- -------------SDAPLTLQNARGLRDVLL------------------- ------------------------T--------------------ASAYR QGL--------QELITGSL----------------PTALSSLQEAASGLC PRPV------------------------------LVQVYTALGTCLRKMG -------------------------------------------------- ----------------NPQRAL-----LYLVAALKGGSTWGPPLLE---- -------------------------------------------------- ---------------------------ASRLYRQLGNT----------AA ELESLELLVEALNVT----HS---SEA---------------------PQ LL----------------------------------IEVEL--------- -------------------------------------------------- -----------------LLPRPHPASPLHCGT------------------ -------------------------------------------------- -QSQAKYLL-----------------------------------ASRCLE V------------------------------------------------- -------------------------------------------------- -----GRAED----------AAEHY------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ----------------------------------------LDL------- -------------------------------------------------- -------------------------------------------------- ---------------LALML-DGx-------------------------- -------------------------------------------------- -------------------------xPK---------------------- -------------------------------------------------- -----------------------------------x------F------- -----PPPPPP-GPCIPEVFLEAAAALIQAGRAQDA-------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ----------------------------------------LTVCE----- -------------------------------------------------- -------------------------------------------------- -------ELLSRTSSL-----LPKMPQLW--------------------- ------EDARx--------------------------------------- -------------------------------------------------- -------------------------------------GI----------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- K------------------------------------------------- -----------------------------------------ESPH----- ---------CPSWVSA---------------------------------- -------------------------------------------------- -------------------------------------------------- ----TYLLQGQAWVQL--GAQKEAISEFSRCLELLFRA------------ ----------------------------xxx-DK---------------E Q----------------------------------------------xx- -------xS----------xxxxxxx------------------------ ------------xxV------------------A---------------- -----------------------LQQL----------------------- -------------------------------------------------- ----RAAALISRGLQWVAS------------------------------- ---------------------------GQDTKALQDFLLSV--------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- --QMCPx-----------xA------------------------------ -------------------AGHQDASFH---------------------- -----------------------------LLQTLRRM------------- -------------------------------------------------- --DRRDEATAL---------------------W----------------- -------WRLEAQT-----KL-P----xxNAA----------W------- ------S-----------------------------------------LP LYLETY-------------------------------------------- -------------------------------------------LGWICFP DRETLLEE----------------------------------------FQ TSL----------------------------------------------- ---------------------------xxPxx-L---------------- -------- >ENSUAMP00000031717 x------------------------------------------------- -------------------------------------------------- -----------------------------xxxxxGAATGSRRESISPVKG ESPLLGPRGEQRSCGGVRKRRDPSPLGWGPRRGRAYPATAPSxxPGPA-- -------------------------------------------------- -------xAxM-----------SxxT------------------------ ----------------------xx-xxxxx-------------------- xAS-------------CLDLWREKNDQLVRQAK-xx-xD----------- -------------------------------------------------- ------------xRLS---------------------------------- ----LRRQ----------------------------------------QL AQD---------------------------------------------AL EGFRGLLHSL---------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ---------------------R---------------------------- ------G------------------------------------------- ---LPAAVPVLP-------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- --------------------------------------------LELTVT CNFITLRAS--LAQGFTEDQAQDIQQGLER-------------------- --------------VLETQE-QLG---PRxECGLRGL------------- --WDSI-------------------------------------------- -------------------------------------------------L GYSSLLLELLPALHLLAG-------------------------------- -------------------------------------------------- -------------------------------------LQA---------- -----------------------------------------------ALW LSTDSLGDLTFL-------------------------------------- -------------------------------------LQTLNG------- ---------------NQ--------S---EAS------------------ --ENLLL-----LLKTWSPPAEE--------------------------- -------------------------------------------------- -------------SDAPLTLQDARGLRDVLL------------------- ------------------------T--------------------ASAYR QGL--------QELITGSL----------------PRALSSLQEAASGLC PRPV------------------------------LVQVYTALGTCLRKMG -------------------------------------------------- ----------------NPQRAL-----LYLVAALKGGSTWGPPLLE---- -------------------------------------------------- ---------------------------ASRLYRQLGNT----------AA ELESLELLVEALNVT----HS---SEA---------------------PQ LL----------------------------------IEVEL--------- -------------------------------------------------- -----------------LLPRPHPASPLHCGT------------------ -------------------------------------------------- -QSQAKYLL-----------------------------------ASRCLE V------------------------------------------------- -------------------------------------------------- -----GRAED----------AAEHY------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ----------------------------------------LDL------- -------------------------------------------------- -------------------------------------------------- ---------------LALML-DGS-------------------------- -------------------------------------------------- -------------------------xPK---------------------- -------------------------------------------------- -----------------------------------F------F------- -----PPPPPP-GPCIPEVFLEAAAALIQAGRAQDA-------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ----------------------------------------LTVCE----- -------------------------------------------------- -------------------------------------------------- -------ELLSRTSSL-----LPKMPQLW--------------------- ------EDARx--------------------------------------- -------------------------------------------------- -------------------------------------GT----------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- K------------------------------------------------- -----------------------------------------ESPH----- ---------CPSWVSA---------------------------------- -------------------------------------------------- -------------------------------------------------- ----TYLLQGQAWVQL--GAQKEAISEFSRCLELLFRA------------ ----------------------------xxx-DK---------------E Q----------------------------------------------xx- -------xS----------xxxxxxx------------------------ ------------xxV------------------A---------------- -----------------------LQQL----------------------- -------------------------------------------------- ----RAAALISRGLQWVAS------------------------------- ---------------------------GQDTKALQDFLLSV--------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- --QMCP-------------------------------------------- --------------------GHQDASFH---------------------- -----------------------------LLQTLRRM------------- -------------------------------------------------- --DRRDEATAL---------------------W----------------- -------WRLEAQT-----KL-P----xxNAA----------W------- ------S-----------------------------------------LP LYLETY-------------------------------------------- -------------------------------------------LGWICFP DRETLLEE----------------------------------------FQ TSL----------------------------------------------- ---------------------------xxPCD-L---------------- -------- >ENSUMAP00000008385 -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ----------M-----------SxxT------------------------ ----------------------xx-xxxxx-------------------- xAS-------------CLDLWREKNDQLVRQAK-xx-xD----------- -------------------------------------------------- ------------xRLS---------------------------------- ----LRRQ----------------------------------------QL AQD---------------------------------------------AL EGFRGLLHSL---------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ---------------------R---------------------------- ------G------------------------------------------- ---LPAAVPVLP-------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- --------------------------------------------LELTVT CNFITLRAS--LAQGFTEDQAQDIQQGLER-------------------- --------------VLETQE-QLG---PRxECGLRGL------------- --WDSI-------------------------------------------- -------------------------------------------------L GYSSLLLELLPALHLLAG-------------------------------- -------------------------------------------------- -------------------------------------LQA---------- -----------------------------------------------ALW LSTDSLGDLTFL-------------------------------------- -------------------------------------LQTLNG------- ---------------NQ--------S---EAS------------------ --ENLLL-----LLKTWSPPAEE--------------------------- -------------------------------------------------- -------------SDAPLTLQDARGLRDVLL------------------- ------------------------T--------------------ASAYR QGL--------QELITGSL----------------PRALSSLQEAASGLC PRPV------------------------------LAQVYTALGTCLRKMG -------------------------------------------------- ----------------NPQRAL-----LYLVAALKGGSTWGPPLLE---- -------------------------------------------------- ---------------------------ASRLYRQLGNT----------AA ELESLELLVEALNVT----HS---SEA---------------------PQ LL----------------------------------IEVEL--------- -------------------------------------------------- -----------------LLPRPHPASPLHCGT------------------ -------------------------------------------------- -QSQAKYLL-----------------------------------ASRCLE V------------------------------------------------- -------------------------------------------------- -----GRAED----------AAEHY------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ----------------------------------------LDL------- -------------------------------------------------- -------------------------------------------------- ---------------LALML-DGS-------------------------- -------------------------------------------------- -------------------------xPK---------------------- -------------------------------------------------- -----------------------------------F------F------- -----PPPPPP-GPCIPEVFLEAAAALIQAGRAQDA-------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ----------------------------------------LTVCE----- -------------------------------------------------- -------------------------------------------------- -------ELLSRTSSL-----LPKMPQLW--------------------- ------EDARx--------------------------------------- -------------------------------------------------- -------------------------------------GT----------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- K------------------------------------------------- -----------------------------------------ESPH----- ---------CPSWVSA---------------------------------- -------------------------------------------------- -------------------------------------------------- ----TYLLQGQAWVQL--GAQKEAISEFSRCLELLFRA------------ ----------------------------xxx-DK---------------E Q----------------------------------------------xx- -------xS----------xxxxxxx------------------------ ------------xxV------------------A---------------- -----------------------LQQL----------------------- -------------------------------------------------- ----RAAALISRGLQWVAS------------------------------- ---------------------------GQDTKALQDFLLSV--------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- --QMCP-------------------------------------------- --------------------GHQDASFH---------------------- -----------------------------LLQTLRRM------------- -------------------------------------------------- --DRRDEATAL---------------------W----------------- -------WRLEAQT-----KL-P----xxNAA----------W------- ------S-----------------------------------------LP LYLETY-------------------------------------------- -------------------------------------------LGWICFP DRETLLEE----------------------------------------FQ TSL----------------------------------------------- ---------------------------xxPCD-L---------------- -------- >ENSNVIP00000031193 -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ----------M-----------SxxT------------------------ ----------------------xx-xxxxx-------------------- xTS-------------CLDLWREKNDQLVRQAK-xx-QD----------- -------------------------------------------------- ------------xGLS---------------------------------- ----LRRQ----------------------------------------QL AQD---------------------------------------------AL EGFRGLLHSL---------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ---------------------R---------------------------- ------G------------------------------------------- ---LPAAVPVLP-------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- --------------------------------------------LELTVT CNFITLKAS--LAQGFTEDQAQDIQQGLERGVPQTRSTFVTFGLLQKEKS RDEVPTSAVCLSSTVLETQK-KLG---PRxECGLRGL------------- --WDSV-------------------------------------------- -------------------------------------------------L HYSTLLLEVLPALHHLAG-------------------------------- -------------------------------------------------- -------------------------------------LQA---------- -----------------------------------------------AIW LSTDCLGDLTFL-------------------------------------- -------------------------------------LQTLNG------- ---------------NQ--------S---EAS------------------ --ENLLL-----LLKTWSPPAEE--------------------------- -------------------------------------------------- -------------SDVPLTLQDARGLRDILL------------------- ------------------------T--------------------ASAYR QGL--------QELITGSL----------------PRALSSLQEAASGLC SRPV------------------------------LVQVYTALGTCLRKMG -------------------------------------------------- ----------------NPQRAL-----LYLAAALKGGSTCGPPLLE---- -------------------------------------------------- ---------------------------ASRLYRQLGNT----------AA ELESLELLVEALNVT----HS---FEA---------------------PQ LL----------------------------------IEVEL--------- -------------------------------------------------- -----------------LLPRPHPASPLHCGT------------------ -------------------------------------------------- -QSQAKYLL-----------------------------------ASRCLQ V------------------------------------------------- -------------------------------------------------- -----GRAED----------AAEHY------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ----------------------------------------LDL------- -------------------------------------------------- -------------------------------------------------- ---------------LALVL-DGS-------------------------- -------------------------------------------------- -------------------------xSK---------------------- -------------------------------------------------- -----------------------------------F------F------- -----PPPSPP-GPCMPEVFLEAAAALIQAGRAQDA-------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ----------------------------------------LTVCE----- -------------------------------------------------- -------------------------------------------------- -------ELLSRTSSL-----LPKMPQLR--------------------- ------EDARx--------------------------------------- -------------------------------------------------- -------------------------------------GT----------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- K------------------------------------------------- -----------------------------------------ESPH----- ---------CPSWVSA---------------------------------- -------------------------------------------------- -------------------------------------------------- ----TYLLQGQAWVQL--GAPKEAISEFSRCLELLFRT------------ ----------------------------xxx-DE---------------E Q----------------------------------------------xx- -------xS----------xxxxxxx------------------------ ------------xxV------------------A---------------- -----------------------LQQL----------------------- -------------------------------------------------- ----RAAALISRGLQWVTI------------------------------- ---------------------------GQDTKALQDFLLSV--------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- --QMCP-------------------------------------------- --------------------GYQDASFH---------------------- -----------------------------LLQTLRRM------------- -------------------------------------------------- --DRRHEATAL---------------------W----------------- -------WRLKAQT-----EL-P----xxNAA----------W------- ------S-----------------------------------------LP LYLETY-------------------------------------------- -------------------------------------------LDWIHSP DRETLLEE----------------------------------------FQ TSL----------------------------------------------- ---------------------------xxPPD-L---------------- -------- >ENSMPUP00000004563 -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ----------M-----------SxxN------------------------ ----------------------xx-xxxxx-------------------- xTS-------------CLDLWREKNDQLVRQAK-Vx-QD----------- -------------------------------------------------- ------------xGLS---------------------------------- ----LRRQ----------------------------------------QL AQD---------------------------------------------SL EGFRGLLHSL---------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ---------------------R---------------------------- ------G------------------------------------------- ---LPAAVPVLP-------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- --------------------------------------------LELTVT CNFITLRAS--LAQGFTEDQAQDIQQGLER-------------------- --------------VLETQK-KLG---PRxECGLRGL------------- --WDSV-------------------------------------------- -------------------------------------------------L HYSTLLLEVLPALHHLAG-------------------------------- -------------------------------------------------- -------------------------------------LQA---------- -----------------------------------------------AVW LSTDCLGDLTFL-------------------------------------- -------------------------------------LQTLNG------- ---------------NQ--------S---EAS------------------ --ENLLL-----LLKTWSPPAEE--------------------------- -------------------------------------------------- -------------SDAPLTLQDARGLRDILL------------------- ------------------------T--------------------ASAYR QGL--------QELITGSL----------------PRALSSLQEAASGLC SRPV------------------------------LVQVYTALGTCLRKMG -------------------------------------------------- ----------------NPQRAL-----LYLAAALKGGSTCGPPLLE---- -------------------------------------------------- ---------------------------ASRLYRQLGNT----------AA ELESLELLVEALNVT----HS---FEA---------------------PQ LL----------------------------------IEVEL--------- -------------------------------------------------- -----------------LLPRPHPASPLHCGT------------------ -------------------------------------------------- -PSQAKYLL-----------------------------------ASRCLQ V------------------------------------------------- -------------------------------------------------- -----GRAED----------AAEHY------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ----------------------------------------LDL------- -------------------------------------------------- -------------------------------------------------- ---------------LALVL-DGS-------------------------- -------------------------------------------------- -------------------------xSK---------------------- -------------------------------------------------- -----------------------------------F------F------- -----PPPSPP-GPCMPEVFLEAAAALIQAGRAQDA-------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ----------------------------------------LTVCE----- -------------------------------------------------- -------------------------------------------------- -------ELLSRTSSL-----LPKMPQLR--------------------- ------EDARx--------------------------------------- -------------------------------------------------- -------------------------------------GT----------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- K------------------------------------------------- -----------------------------------------ESPH----- ---------CPSWVSA---------------------------------- -------------------------------------------------- -------------------------------------------------- ----TYLLQGQAWVQL--GAPKEAISEFSRCLELLFRT------------ ----------------------------xxx-DE---------------E Q----------------------------------------------xx- -------xS----------xxxxxxx------------------------ ------------xxV------------------A---------------- -----------------------LQQL----------------------- -------------------------------------------------- ----RAAALISRGLQWVAV------------------------------- ---------------------------DQDTKALQDFLLSV--------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- --QMCP-------------------------------------------- --------------------GNQDASFH---------------------- -----------------------------LLQTLRRM------------- -------------------------------------------------- --DRRHEATAL---------------------W----------------- -------WRLKAQT-----EL-P----xxNAA----------W------- ------S-----------------------------------------LP LYLETY-------------------------------------------- -------------------------------------------LDWIHSP DREALLEE----------------------------------------FQ TSL----------------------------------------------- ---------------------------xxPHE-L---------------- -------- >ENSVVUP00000036467 xxxxxxxxxxxxxxxxxxxxxxx--------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- xTS-------------CLDLWREKNDQLVRQAK-Vx-QD----------- -------------------------------------------------- ------------xRLY---------------------------------- ----VRRQ----------------------------------------QL AQD---------------------------------------------AL EGFRGLLHSL---------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ---------------------Q---------------------------- ------G------------------------------------------- ---LPAAVPVLP-------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- --------------------------------------------LELTVT CNFITLRAT--LAQGFTEDQAQDIQKGLER-------------------- --------------VLETQE-QLG---PRxECGLRGL------------- --WDSV-------------------------------------------- -------------------------------------------------L HYSSLLLELLPVLHHLAG-------------------------------- -------------------------------------------------- -------------------------------------LQA---------- -----------------------------------------------ALW LSTDHLGDLTLL-------------------------------------- -------------------------------------LQTLNG------- ---------------KQ--------S---EAS------------------ --ENLLL-----LLKTWSPPPKE--------------------------- -------------------------------------------------- -------------SDAPLTLQDARGLRDVLL------------------- ------------------------T--------------------AAAYR QGL--------QELITGSL----------------PRALSSLQEAASGLC SRPV------------------------------LVQVYTALGTCLHKMG -------------------------------------------------- ----------------NPQRAL-----LYLVAALKEGSTWGLPLLE---- -------------------------------------------------- ---------------------------ASRLYRQLGNT----------AA ELESLEL--------------------x----xxxx--------xxxxPQ LL----------------------------------IEVEL--------- -------------------------------------------------- -----------------LLPQPHPGSPLHCGT------------------ -------------------------------------------------- -QSQAKYLL-----------------------------------ASRSLQ V------------------------------------------------- -------------------------------------------------- -----GRAED----------AAEHY------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ----------------------------------------LDL------- -------------------------------------------------- -------------------------------------------------- ---------------LALLL-DDS-------------------------- -------------------------------------------------- -------------------------xPK---------------------- -------------------------------------------------- -----------------------------------F------S------- -----PPPTHP-GPCMPEVFLEAAAALIQAGRAQDA-------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ----------------------------------------LTVCE----- -------------------------------------------------- -------------------------------------------------- -------ELLSRTSSL-----LPKMPQLW--------------------- ------EDDKx--------------------------------------- -------------------------------------------------- -------------------------------------GT----------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- K------------------------------------------------- -----------------------------------------KPPH----- ---------CPSWVSA---------------------------------- -------------------------------------------------- -------------------------------------------------- ----TYLLQGQAWVQL--GDQKEAISEFSRCLELLFRT------------ ----------------------------xxx-GK---------------E Q----------------------------------------------xx- -------xS----------xxxxxxx------------------------ ------------xxV------------------A---------------- -----------------------LPQL----------------------- -------------------------------------------------- ----RAAALISRGLRWVAS------------------------------- ---------------------------GQDTRALQDFLLGV--------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- --QMCP-------------------------------------------- --------------------GNQDASFH---------------------- -----------------------------LLQTLRRM------------- -------------------------------------------------- --DRRDEATAL---------------------W----------------- -------WRLEAQT-----KL-P----xxNAA----------W------- ------S-----------------------------------------LP LYLETC-------------------------------------------- -------------------------------------------LGWICYP DRETLLEE----------------------------------------FR TSL----------------------------------------------- ---------------------------xxPCD-L---------------- -------- >ENSCAFP00020020465 x---------------------xxxxxPPAEGQSWADLEAWLRAEGWDTV SGTEIDCSRFRPARGTGKPNREKYNLPTQTHPHPLVRRRLPFRMESPHVS SSSFPRGLTLEDDQPQQRVLSAGPTRGEMEEAGVGAGTESPRESISPEKA DSPLRGPSGEQKSRGRVRKRRDLSPLGWGPRRDRPYPSADPSxxPGPA-- -------------------------------------------------- -------xAxI-----------SxxT------------------------ ----------------------xx-xxxxx-------------------- xTS-------------CLDLWREKNDQLVRQAK-xx-xD----------- -------------------------------------------------- ------------xRLY---------------------------------- ----VRRQ----------------------------------------QL AQD---------------------------------------------AL EGFRGLLHSL---------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ---------------------Q---------------------------- ------G------------------------------------------- ---LPAAVPVLP-------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- --------------------------------------------LELTVT CNFITLRAT--LAQGFTEDQAQDIQKGLER-------------------- --------------VLETQE-QLG---PRxECGLRGL------------- --WDSV-------------------------------------------- -------------------------------------------------F HYSSLLLELLPVLHHLAG-------------------------------- -------------------------------------------------- -------------------------------------LQA---------- -----------------------------------------------ALW LSTDHLGDLTLL-------------------------------------- -------------------------------------LQTLNG------- ---------------KQ--------S---EAS------------------ --ENLLL-----LLKTWSPPPKE--------------------------- -------------------------------------------------- -------------SDAPLTLQDARGLRDVLL------------------- ------------------------T--------------------ASAYR QGL--------QELITGSL----------------PRALSSLQEAASGLC SRPV------------------------------LVQVYTALGTCLHKMG -------------------------------------------------- ----------------NPQRAL-----LYLVAALKEGSTWGLPLLE---- -------------------------------------------------- ---------------------------ASRLYRQLGNT----------AA ELESLELLVEALNVT----HS---SEA---------------------PQ LL----------------------------------IEVEL--------- -------------------------------------------------- -----------------LLPQPNPGSPLHCGT------------------ -------------------------------------------------- -QSQAKYLL-----------------------------------ASRCLQ V------------------------------------------------- -------------------------------------------------- -----GRAED----------AAEHY------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ----------------------------------------LDL------- -------------------------------------------------- -------------------------------------------------- ---------------LALLL-SDS-------------------------- -------------------------------------------------- -------------------------xPK---------------------- -------------------------------------------------- -----------------------------------F------S------- -----PPPTHP-GPCMPEVFLEAAAALIQAGRAQDA-------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ----------------------------------------LTVCE----- -------------------------------------------------- -------------------------------------------------- -------ELLSRTSSL-----LPKMPQLW--------------------- ------EDDKx--------------------------------------- -------------------------------------------------- -------------------------------------GT----------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- K------------------------------------------------- -----------------------------------------KSPH----- ---------CPSWVSA---------------------------------- -------------------------------------------------- -------------------------------------------------- ----TYLLQGQAWVQL--GAQKEAISEFSRCLELLFRT------------ ----------------------------xxx-DK---------------E Q----------------------------------------------xx- -------xS----------xxxxxxx------------------------ ------------xxV------------------A---------------- -----------------------LPQL----------------------- -------------------------------------------------- ----RAAALISRGLQWVAS------------------------------- ---------------------------GQDTRALQDFLLGV--------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- --QMCP-------------------------------------------- --------------------GNQDASFH---------------------- -----------------------------LLQTLRKM------------- -------------------------------------------------- --DRRDEASAL---------------------W----------------- -------WRLEAQT-----KL-P----xxNAA----------W------- ------S-----------------------------------------LP LYLETC-------------------------------------------- -------------------------------------------LGWICYP DRETLLEE----------------------------------------FR TSL----------------------------------------------- ---------------------------xxPCD-L---------------- -------- >ENSCAFP00000002933 x---------------------xxxxxPPAEGQSWADLEAWLRAEGWDTV SGTEIDCSRFRPARGTGKPNREKYNLPTQTHPHPLVRRRLPFxMESPxxx xxxxPRGLTLEDDQPQQRVLSAGPTRGEMEEAGVGAGTESPRESISPEKA DSPLRGPSGEQKSRGRVRKRRDLSPLGWEPRRDRPYPSxxxxxxxGPx-- -------------------------------------------------- -------xAxI-----------SxxT------------------------ ----------------------xx-xxxxx-------------------- xTS-------------CLDLWREKNDQLVRQAK-xx-xD----------- -------------------------------------------------- ------------xRLY---------------------------------- ----VRRQ----------------------------------------QL AQD---------------------------------------------AL EGFRGLLHSL---------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ---------------------Q---------------------------- ------G------------------------------------------- ---LPAAVPVLP-------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- --------------------------------------------LELTVT CNFITLRAT--LAQGFTEDQAQDIQKGLER-------------------- --------------VLETQE-QLG---PRxECGLRGL------------- --WDSV-------------------------------------------- -------------------------------------------------F HYSSLLLELLPVLHHLAG-------------------------------- -------------------------------------------------- -------------------------------------LQA---------- -----------------------------------------------ALW LSTDHLGDLTLL-------------------------------------- -------------------------------------LQTLNG------- ---------------KQ--------S---EAS------------------ --ENLLL-----LLKTWSPPPKE--------------------------- -------------------------------------------------- -------------SDAPLTLQDARGLRDVLL------------------- ------------------------T--------------------ASAYR QGL--------QELITGSL----------------PRALSSLQEAASGLC SRPV------------------------------LVQVYTALGTCLHKMG -------------------------------------------------- ----------------NPQRAL-----LYLVAALKEGSTWGLPLLE---- -------------------------------------------------- ---------------------------ASRLYRQLGNT----------AA ELESLELLVEALNVT----HS---SEA---------------------PQ LL----------------------------------IEVEL--------- -------------------------------------------------- -----------------LLPQPNPGSPLHCGT------------------ -------------------------------------------------- -QSQAKYLL-----------------------------------ASRCLQ V------------------------------------------------- -------------------------------------------------- -----GRAED----------AAEHY------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ----------------------------------------LDL------- -------------------------------------------------- -------------------------------------------------- ---------------LALLL-SDS-------------------------- -------------------------------------------------- -------------------------xPK---------------------- -------------------------------------------------- -----------------------------------F------S------- -----PPPTHP-GPCMPEVFLEAAAALIQAGRAQDA-------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ----------------------------------------LTVCE----- -------------------------------------------------- -------------------------------------------------- -------ELLSRTSSL-----LPKMPQLW--------------------- ------EDDKx--------------------------------------- -------------------------------------------------- -------------------------------------GT----------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- K------------------------------------------------- -----------------------------------------KSPH----- ---------CPSWVSA---------------------------------- -------------------------------------------------- -------------------------------------------------- ----TYLLQGQAWVQL--GAQKEAISEFSRCLELLFRT------------ ----------------------------xxx-DK---------------E Q----------------------------------------------xx- -------xS----------xxxxxxx------------------------ ------------xxV------------------A---------------- -----------------------LPQL----------------------- -------------------------------------------------- ----RAAALISRGLQWVAS------------------------------- ---------------------------GQDTRALQDFLLGV--------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- --QMCP-------------------------------------------- --------------------GNQDASFH---------------------- -----------------------------LLQTLRKM------------- -------------------------------------------------- --DRRDEASAL---------------------W----------------- -------WRLEAQT-----KL-P----xxNAA----------W------- ------S-----------------------------------------LP LYLETC-------------------------------------------- -------------------------------------------LGWICYP DRETLLEE----------------------------------------FR TSL----------------------------------------------- ---------------------------xxPCD-L---------------- -------- >ENSPTIP00000012020 x------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -----------------xxxxDLSSLGWGPRRGRAYLSAAPSxxLGPA-- -------------------------------------------------- -------xAxL-----------SxxT------------------------ ----------------------xx-xxxxx-------------------- xAS-------------CLDLWREKNDQLVRQAK-Vx-QD----------- -------------------------------------------------- ------------xRQF---------------------------------- ----LRGQ----------------------------------------QL AQD---------------------------------------------VL EGFRGLLHSL---------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ---------------------Q---------------------------- ------G------------------------------------------- ---LPAAVPVLP-------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- --------------------------------------------LELTVT CNFITMKAS--LAQGFTENQAQDIQQSLER-------------------- --------------VLETQK-QLG---PRxECGLRGL------------- --WDSV-------------------------------------------- -------------------------------------------------L HYSSVLLELLPALHHLAG-------------------------------- -------------------------------------------------- -------------------------------------LQA---------- -----------------------------------------------ALW LSTDCLGDLTLL-------------------------------------- -------------------------------------LQTLNG------- ---------------NQ--------S---EAS------------------ --EDLLH-----LLKTWSPPAEE--------------------------- -------------------------------------------------- -------------SDAPLTLQDARGLRDVLL------------------- ------------------------T--------------------ASAYR QGL--------QELITGSL----------------PKALSSLQEAASGLC PRPV------------------------------LVQVYTVLGTCLRKMG -------------------------------------------------- ----------------NPQRAL-----LYLVAALKGGSPWGPPLLE---- -------------------------------------------------- ---------------------------ASRLYQQLGNT----------AA ELESLELLVDALSVT----HS---PEA---------------------PQ LL----------------------------------IEVEL--------- -------------------------------------------------- -----------------LLPQPNPASPLHCGT------------------ -------------------------------------------------- -QSQAKYLL-----------------------------------ASRCLQ I------------------------------------------------- -------------------------------------------------- -----GRAED----------AAEHY------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ----------------------------------------LDL------- -------------------------------------------------- -------------------------------------------------- ---------------LALLL-DDS-------------------------- -------------------------------------------------- -------------------------xPK---------------------- -------------------------------------------------- -----------------------------------F------S------- -----PPPSRP-GPCMPEVFLEAAAALIQAGRAQDA-------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ----------------------------------------LTVCE----- -------------------------------------------------- -------------------------------------------------- -------ELLSRMSSL-----LPKMPQLW--------------------- ------EDARx--------------------------------------- -------------------------------------------------- -------------------------------------GT----------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- K------------------------------------------------- -----------------------------------------ESPH----- ---------CLSWVSA---------------------------------- -------------------------------------------------- -------------------------------------------------- ----TYLLQGRAWVQL--GAQKEAISEFSRCLELLFQA------------ ----------------------------xxx-DK---------------E Q----------------------------------------------xx- -------xS----------xxxxxxx------------------------ ------------xxV------------------A---------------- -----------------------LQQL----------------------- -------------------------------------------------- ----RVAALISRGLQWVAS------------------------------- ---------------------------DQDTKALQDFLLSV--------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- --QMCP-------------------------------------------- --------------------GNRDASFH---------------------- -----------------------------LLQTLRRM------------- -------------------------------------------------- --DRRDEAIAL---------------------W----------------- -------WSLEAQA-----KL-P----xxNAA----------W------- ------S-----------------------------------------LP LFLETY-------------------------------------------- -------------------------------------------LSWIRSP DRETLLEE----------------------------------------FQ TSL----------------------------------------------- ---------------------------xxPCD-L---------------- -------- >ENSPPRP00000009227 -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ----------L-----------SHQT------------------------ ----------------------xx-xxxxx-------------------- xAS-------------CLDLWREKNDQLVRQAK-Vx-QD----------- -------------------------------------------------- ------------xRQF---------------------------------- ----LRGQ----------------------------------------QL AQD---------------------------------------------VL EGFRGLLHSL---------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ---------------------Q---------------------------- ------G------------------------------------------- ---LPAAVPVLP-------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- --------------------------------------------LELTVT CNFITMKAS--LAQGFTENQAQDIQQSLER-------------------- --------------VLETQK-QLG---PRxECGLRGL------------- --WDSV-------------------------------------------- -------------------------------------------------L HYSSVLLELLPALHHLAG-------------------------------- -------------------------------------------------- -------------------------------------LQA---------- -----------------------------------------------ALW LSTDCLGDLTLL-------------------------------------- -------------------------------------LQTLNG------- ---------------NQ--------S---EAS------------------ --EDLLH-----LLKTWSPPAEE--------------------------- -------------------------------------------------- -------------SDAPLTLQDARGLRDVLL------------------- ------------------------T--------------------ASAYR QGL--------QELITGSL----------------PKALSSLQEAASGLC PRPV------------------------------LVQVYTVLGTCLRKMG -------------------------------------------------- ----------------NPQRAL-----LYLVAALKGGSPWGPPLLE---- -------------------------------------------------- ---------------------------ASRLYQQLGNT----------AA ELESLELLVDALSVT----HS---PEA---------------------PQ LL----------------------------------IEVEL--------- -------------------------------------------------- -----------------LLPQPNPASPLHCGT------------------ -------------------------------------------------- -QSQAKYLL-----------------------------------ASRCLQ I------------------------------------------------- -------------------------------------------------- -----GRAED----------AAEHY------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ----------------------------------------LDL------- -------------------------------------------------- -------------------------------------------------- ---------------LALLL-DDS-------------------------- -------------------------------------------------- -------------------------xPK---------------------- -------------------------------------------------- -----------------------------------F------S------- -----PPPSRP-GPCMPEVFLEAAAALIQAGRAQDA-------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ----------------------------------------LTVCE----- -------------------------------------------------- -------------------------------------------------- -------ELLSRMSSL-----LPKMPQLW--------------------- ------EDARx--------------------------------------- -------------------------------------------------- -------------------------------------GT----------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- K------------------------------------------------- -----------------------------------------ESPH----- ---------CLSWVSA---------------------------------- -------------------------------------------------- -------------------------------------------------- ----TYLLQGRAWVQL--GAQKEAISEFSRCLELLFQA------------ ----------------------------xxx-DK---------------E Q----------------------------------------------xx- -------xS----------xxxxxxx------------------------ ------------xxV------------------A---------------- -----------------------LQQL----------------------- -------------------------------------------------- ----RVAALISRGLQWVAS------------------------------- ---------------------------DQDTKALQDFLLSV--------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- --QMCP-------------------------------------------- --------------------GNRDASFH---------------------- -----------------------------LLQTLRRM------------- -------------------------------------------------- --DRRDEAIAL---------------------W----------------- -------WSLEAQA-----KL-P----xxNAA----------W------- ------S-----------------------------------------LP LFLETY-------------------------------------------- -------------------------------------------LSWIRSP DRETLLEE----------------------------------------FQ TSL----------------------------------------------- ---------------------------xxPCD-L---------------- -------- >ENSFCAP00000045883 -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ----------L-----------SHQT------------------------ ----------------------xx-xxxxx-------------------- xAS-------------CLDLWREKNDQLVRQAK-Vx-QD----------- -------------------------------------------------- ------------xRQF---------------------------------- ----LRGQ----------------------------------------QL AQD---------------------------------------------VL EGFRGLLHSL---------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ---------------------Q---------------------------- ------G------------------------------------------- ---LPAAVPVLP-------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- --------------------------------------------LELTVT CNFITMKAS--LAQGFTEDQAQDIQQSLER-------------------- --------------VLETQE-QLG---PRxECGLRGL------------- --WDSV-------------------------------------------- -------------------------------------------------L HYSSVLLELLPALHHLAG-------------------------------- -------------------------------------------------- -------------------------------------LQA---------- -----------------------------------------------ALW LSTDCLGDLTLL-------------------------------------- -------------------------------------LQTLNG------- ---------------NQ--------S---EAS------------------ --EDLLH-----LLKTWSPPAEE--------------------------- -------------------------------------------------- -------------SDAPLTLQDARGLRDVLL------------------- ------------------------T--------------------ASAYR QGL--------QELITGSL----------------PKALSSLQEAASGLC PRPV------------------------------LVQVYTVLGTCLRKMG -------------------------------------------------- ----------------NPQRAL-----LYLVAALKGGSPWGPPLLE---- -------------------------------------------------- ---------------------------ASRLYQQLGNT----------AA ELESLELLVDALSVT----HS---PEA---------------------PQ LL----------------------------------IEVEL--------- -------------------------------------------------- -----------------LLPQPNPASPLHCGT------------------ -------------------------------------------------- -QSQAKYLL-----------------------------------ASRCLQ I------------------------------------------------- -------------------------------------------------- -----GRAED----------AAEHY------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ----------------------------------------LDL------- -------------------------------------------------- -------------------------------------------------- ---------------LALLL-DDS-------------------------- -------------------------------------------------- -------------------------xPK---------------------- -------------------------------------------------- -----------------------------------F------S------- -----PPPSRP-GPCMPEVFLEAAAALIQAGRAQDA-------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ----------------------------------------LTVCE----- -------------------------------------------------- -------------------------------------------------- -------ELLSRMSSL-----LPKMPQLW--------------------- ------EDARx--------------------------------------- -------------------------------------------------- -------------------------------------GT----------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- K------------------------------------------------- -----------------------------------------ESPH----- ---------CLSWVSA---------------------------------- -------------------------------------------------- -------------------------------------------------- ----TYLLQGRAWVQL--GAQKEAISEFSRCLELLFQA------------ ----------------------------xxx-DK---------------E Q----------------------------------------------xx- -------xS----------xxxxxxx------------------------ ------------xxV------------------A---------------- -----------------------LQQL----------------------- -------------------------------------------------- ----RVAALISRGLQWVAS------------------------------- ---------------------------DQDTKALQDFLLSV--------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- --QMCP-------------------------------------------- --------------------GNRDASFH---------------------- -----------------------------LLQTLRRM------------- -------------------------------------------------- --DRRDEAIAL---------------------W----------------- -------RSLEAQA-----KL-P----xxNAA----------W------- ------S-----------------------------------------LP LYLETY-------------------------------------------- -------------------------------------------LSWIRSP DRETLLEE----------------------------------------FQ TSL----------------------------------------------- ---------------------------xxPCD-L---------------- -------- >ENSEASP00005020000 -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ----------------------xxxxxxxxxxxx---------------- -----xG------------------------------------------- ---LPAAVPVLP-------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- --------------------------------------------LELTVI CNFITLRAS--LAQGFTEDQAQGIQQGLER-------------------- --------------VLETQE-QLE---PRxECGLSAL------------- --WDSV-------------------------------------------- -------------------------------------------------L HSSSLLPELLPALHHLAA-------------------------------- -------------------------------------------------- -------------------------------------LQA---------- -----------------------------------------------ALW LTTDHLGDLTLL-------------------------------------- -------------------------------------LQTLNG------- ---------------SQ--------S---GAS------------------ --EDLLL-----LLKTWNLPAEE--------------------------- -------------------------------------------------- -------------SDAPLTIQDARGLRDVLL------------------- ------------------------T--------------------ASAYR QGL--------QELITGRL----------------SRALSSLHEAASGLC PQPV------------------------------LVQVYTALGTCLSKMG -------------------------------------------------- ----------------NPQRAL-----LYLLSALKGGSTWGPALLE---- -------------------------------------------------- ---------------------------ASRLYRQLGNT----------AA ELESLELLVEALSIT----HG---SEA---------------------PQ LL----------------------------------IEVEL--------- -------------------------------------------------- -----------------LLPRPEPASPLYCGT------------------ -------------------------------------------------- -QSQAKYLL-----------------------------------ASRCLQ T------------------------------------------------- -------------------------------------------------- -----GRAED----------AAEHY------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ----------------------------------------LDL------- -------------------------------------------------- -------------------------------------------------- ---------------LALLL-DGS-------------------------- -------------------------------------------------- -------------------------xPK---------------------- -------------------------------------------------- -----------------------------------I------S------- -----PPPCPT-GPCMPEVFLEAAAALIRAGRAQDA-------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ----------------------------------------LTVCE----- -------------------------------------------------- -------------------------------------------------- -------ELLSRMSSL-----LPKMPQPW--------------------- ------GNARx--------------------------------------- -------------------------------------------------- -------------------------------------GT----------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- K------------------------------------------------- -----------------------------------------ESPH----- ---------CPPWVSA---------------------------------- -------------------------------------------------- -------------------------------------------------- ----THLLRGQAWVQL--GAQKEAISEFSRCLELLFRA------------ ----------------------------xxx-DK---------------E Q----------------------------------------------xx- -------xS----------xxxxxxx------------------------ ------------xxV------------------A---------------- -----------------------LQQL----------------------- -------------------------------------------------- ----RAAALISRGLGWVTS------------------------------- ---------------------------GQDTKALQDFLLSV--------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- --QMCP-------------------------------------------- --------------------GNQDASFH---------------------- -----------------------------LLQTLRRL------------- -------------------------------------------------- --DRRDEAIAF---------------------W----------------- -------RRLEAQT-----KL-P----xxNAT----------W------- ------S-----------------------------------------LP LYLETC-------------------------------------------- -------------------------------------------LSWIRPH DRETLLEE----------------------------------------FQ TSL----------------------------------------------- ---------------------------xxPCD-L---------------- -------- >ENSECAP00000013855 -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ----------R-----------SxxT------------------------ ----------------------xx-xxxxx-------------------- xAS-------------CLDLWRQRNDQLVRQAK-Vx-Qx----------- -------------------------------------------------- --------------LS---------------------------------- ----LRRQ----------------------------------------QL AQD---------------------------------------------AL EGFRELLHCL---------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ---------------------Q---------------------------- ------G------------------------------------------- ---LPAAVPVLP-------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- --------------------------------------------LELTVI CNFITLRAS--LAQGFTEDQAQGIQQGLER-------------------- --------------VLETQE-QLE---PRxECGLSAL------------- --WDSV-------------------------------------------- -------------------------------------------------L HSSSLLPELLPALHHLAA-------------------------------- -------------------------------------------------- -------------------------------------LQA---------- -----------------------------------------------ALW LTTDHLGDLTLL-------------------------------------- -------------------------------------LQTLNG------- ---------------SQ--------S---GAS------------------ --EDLLL-----LLKTWNLPAEE--------------------------- -------------------------------------------------- -------------SDAPLTIQDARGLRDVLL------------------- ------------------------T--------------------ASAYR QGL--------QELITGRL----------------SRALSSLHEAASGLC PQPV------------------------------LVQVYTALGTCLSKMG -------------------------------------------------- ----------------NPQRAL-----LYLLSALKGGSTWGPALLE---- -------------------------------------------------- ---------------------------ASRLYRQLGNT----------AA ELESLELLVETLSIT----HG---SEA---------------------PQ LL----------------------------------IEVEL--------- -------------------------------------------------- -----------------LLPRPEPASPLYCGT------------------ -------------------------------------------------- -QSQAKYLL-----------------------------------ASRCLQ T------------------------------------------------- -------------------------------------------------- -----GRAED----------AAEHY------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ----------------------------------------LDL------- -------------------------------------------------- -------------------------------------------------- ---------------LALLL-DGS-------------------------- -------------------------------------------------- -------------------------xPK---------------------- -------------------------------------------------- -----------------------------------I------S------- -----PPPCPT-GPCMPEVFLEAAAALIRAGRAQDA-------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ----------------------------------------LTVCE----- -------------------------------------------------- -------------------------------------------------- -------ELLSRMSSL-----LPKMPQPW--------------------- ------GNARx--------------------------------------- -------------------------------------------------- -------------------------------------GT----------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- K------------------------------------------------- -----------------------------------------ESPH----- ---------CPPWVSA---------------------------------- -------------------------------------------------- -------------------------------------------------- ----THLLRGQAWVQL--GAQKEAISEFSRCLELLFRA------------ ----------------------------xxx-DK---------------E Q----------------------------------------------xx- -------xS----------xxxxxxx------------------------ ------------xxV------------------A---------------- -----------------------LQQL----------------------- -------------------------------------------------- ----RAAALISRGLGWVTS------------------------------- ---------------------------GQDTKALQDFLLSV--------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- --QMCP-------------------------------------------- --------------------GNQDASFH---------------------- -----------------------------LLQTLRRL------------- -------------------------------------------------- --DRRDEAIAL---------------------W----------------- -------RRLEAQT-----KL-P----xxNAT----------W------- ------S-----------------------------------------LP LYLETC-------------------------------------------- -------------------------------------------LSWICPH DRETLLEE----------------------------------------FQ TSL----------------------------------------------- ---------------------------xxPCD-L---------------- -------- >ENSBIXP00000015257 -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ----------M-----------AxxT------------------------ ----------------------xx-xxxxx-------------------- xVS-------------CLDLWREKNDQLVRQAK-Vx-QD----------- -------------------------------------------------- ------------xSLP---------------------------------- ----MRRQ----------------------------------------QL AQD---------------------------------------------AL EGLRGLLCSL---------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ---------------------R---------------------------- ------G------------------------------------------- ---LPATVSVLP-------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- --------------------------------------------LELTVI CNFITLRAN--LAQGFTEDLAQDIQQGLER-------------------- --------------VLETQG-QLE---ARxEHGLWGL------------- --WDST-------------------------------------------- -------------------------------------------------L RVSSLLPELLPALHHLAG-------------------------------- -------------------------------------------------- -------------------------------------LQA---------- -----------------------------------------------ALW LTTNRLGDLTLL-------------------------------------- -------------------------------------LQTLTV------- ---------------SQ--------S---RAS------------------ --EDMLL-----LLKTWRPPAEE--------------------------- -------------------------------------------------- -------------SDAPLTLQDARGLRDVLL------------------- ------------------------T--------------------AFAYR QGL--------QELITGSL----------------PKALSSLHEAASGLC PRSL------------------------------LVQVYTALGTCLRKMG -------------------------------------------------- ----------------SPQRAL-----LYLVAALKEGSTWGPPLLE---- -------------------------------------------------- ---------------------------ASRLYQQLGNI----------AA EIESLELLVEALSIT----RI---PEA---------------------RQ LL----------------------------------IEVEL--------- -------------------------------------------------- -----------------LLPQPDPASPLHCGT------------------ -------------------------------------------------- -QSQAKYLL-----------------------------------ASRCLQ T------------------------------------------------- -------------------------------------------------- -----GRAAD----------AAEHY------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ----------------------------------------LDL------- -------------------------------------------------- -------------------------------------------------- ---------------LALLL-DGS-------------------------- -------------------------------------------------- -------------------------xPK---------------------- -------------------------------------------------- -----------------------------------F------S------- -----PPPCPP-GPCVPELFLEAAAALIQAGRAQDA-------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ----------------------------------------LTVCE----- -------------------------------------------------- -------------------------------------------------- -------ELLSRTSFL-----LPKRPRLW--------------------- ------EDARx--------------------------------------- -------------------------------------------------- -------------------------------------RT----------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- K------------------------------------------------- -----------------------------------------ESPH----- ---------CSHWVSA---------------------------------- -------------------------------------------------- -------------------------------------------------- ----THLLQGQAWVQL--GAQKEAISEYSRCLELLFRA------------ ----------------------------xxx-DK---------------E Q----------------------------------------------xx- -------xS----------xxxxxxx------------------------ ------------xxM------------------A---------------- -----------------------LQQL----------------------- -------------------------------------------------- ----QTAALISRGLEWVAL------------------------------- ---------------------------GQDTKALQDFLLSV--------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- --QMCP-------------------------------------------- --------------------GNQDASYH---------------------- -----------------------------LLQTLRRL------------- -------------------------------------------------- --DRRDEATAL---------------------W----------------- -------RRLEAQT-----EL-P----xxNTA----------W------- ------S-----------------------------------------LP LYLETC-------------------------------------------- -------------------------------------------LGWIRPP DRETLCEE----------------------------------------FQ TS------------------------------------------------ ----------------------------x--x-x---------------- -------- >ENSBIXP00005030608 -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ----------M-----------AxxT------------------------ ----------------------xx-xxxxx-------------------- xVS-------------CLDLWREKNDQLVRQAK-Vx-QD----------- -------------------------------------------------- ------------xSLP---------------------------------- ----MRRQ----------------------------------------QL AQD---------------------------------------------AL EGLRGLLCSL---------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ---------------------R---------------------------- ------G------------------------------------------- ---LPATVSVLP-------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- --------------------------------------------LELTVI CNFITLRAN--LAQGFTEDLAQDIQQGLER-------------------- --------------VLETQG-QLE---ARxEHGLWGL------------- --WDST-------------------------------------------- -------------------------------------------------L RVSSLLPELLPALHHLAG-------------------------------- -------------------------------------------------- -------------------------------------LQA---------- -----------------------------------------------ALW LTTNRLGDLTLL-------------------------------------- -------------------------------------LQTLTV------- ---------------SQ--------S---RAS------------------ --EDMLL-----LLKTWRPPAEE--------------------------- -------------------------------------------------- -------------SDAPLTLQDARGLRDVLL------------------- ------------------------T--------------------AFAYR QGL--------QELITGSL----------------PKALSSLHEAASGLC PRSL------------------------------LVQVYTALGTCLRKMG -------------------------------------------------- ----------------SPQRAL-----LYLVAALKEGSTWGPPLLE---- -------------------------------------------------- ---------------------------ASRLYQQLGNI----------AA EIESLELLVEALSIT----RI---PEA---------------------RQ LL----------------------------------IEVEL--------- -------------------------------------------------- -----------------LLPQPDPASPLHCGT------------------ -------------------------------------------------- -QSQAKYLL-----------------------------------ASRCLQ T------------------------------------------------- -------------------------------------------------- -----GRAAD----------AAEHY------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ----------------------------------------LDL------- -------------------------------------------------- -------------------------------------------------- ---------------LALLL-DGS-------------------------- -------------------------------------------------- -------------------------xPK---------------------- -------------------------------------------------- -----------------------------------F------S------- -----PPPCPP-GPCVPELFLEAAAALIQAGRAQDA-------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ----------------------------------------LTVCE----- -------------------------------------------------- -------------------------------------------------- -------ELLSRTSFL-----LPKRPRLW--------------------- ------EDARx--------------------------------------- -------------------------------------------------- -------------------------------------RT----------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- K------------------------------------------------- -----------------------------------------ESPH----- ---------CSHWVSA---------------------------------- -------------------------------------------------- -------------------------------------------------- ----THLLQGQAWVQL--GAQKEAISEYSRCLELLFRA------------ ----------------------------xxx-DK---------------E Q----------------------------------------------xx- -------xS----------xxxxxxx------------------------ ------------xxM------------------A---------------- -----------------------LQQL----------------------- -------------------------------------------------- ----QTAALISRGLEWVAL------------------------------- ---------------------------GQDTKALQDFLLSV--------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- --QMCP-------------------------------------------- --------------------GNQDASYH---------------------- -----------------------------LLQTLRRL------------- -------------------------------------------------- --DRRDEATAL---------------------W----------------- -------RRLEAQT-----EL-P----xxNTA----------W------- ------S-----------------------------------------LP LYLETC-------------------------------------------- -------------------------------------------LGWIRPP DRETLCEE----------------------------------------FQ TS------------------------------------------------ ----------------------------x--x-x---------------- -------- >ENSBBBP00000007203 -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ----------M-----------AxxT------------------------ ----------------------xx-xxxxx-------------------- xVS-------------CLDLWREKNDQLVRQAK-Vx-QD----------- -------------------------------------------------- ------------xSLP---------------------------------- ----MRRQ----------------------------------------QL AQD---------------------------------------------AL EGLRGLLCSL---------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ---------------------R---------------------------- ------G------------------------------------------- ---LPATVSVLP-------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- --------------------------------------------LELTVI CNFITLRAN--LAQGFTEDLAQDIQQGLER-------------------- --------------VLETQG-QLE---ARxEHGLWGL------------- --WDST-------------------------------------------- -------------------------------------------------L RVSSLLPELLPALHHLAG-------------------------------- -------------------------------------------------- -------------------------------------LQA---------- -----------------------------------------------ALW LTTNCLGDLTLL-------------------------------------- -------------------------------------LQTLTV------- ---------------SQ--------S---RAS------------------ --EDMLL-----LLKTWRPPAEE--------------------------- -------------------------------------------------- -------------SDAPLTLQDARGLRDVLL------------------- ------------------------T--------------------AFAYR QGL--------QELITGSL----------------PKALSSLHEAASGLC PRSL------------------------------LVQVYTALGTCLRKMG -------------------------------------------------- ----------------SPQRAL-----LYLVAALKEGSTWGPPLLE---- -------------------------------------------------- ---------------------------ASRLYQQLGNI----------AA EIESLELLVEALSIT----RI---PEA---------------------RQ LL----------------------------------IEVEL--------- -------------------------------------------------- -----------------LLPQPDPASPLHCGT------------------ -------------------------------------------------- -QSQAKYLL-----------------------------------ASRCLQ T------------------------------------------------- -------------------------------------------------- -----GRAAD----------AAEHY------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ----------------------------------------LDL------- -------------------------------------------------- -------------------------------------------------- ---------------LALLL-DGS-------------------------- -------------------------------------------------- -------------------------xPK---------------------- -------------------------------------------------- -----------------------------------F------S------- -----PPPCPP-GPCVPELFLEAAAALIQAGRAQDA-------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ----------------------------------------LTVCE----- -------------------------------------------------- -------------------------------------------------- -------ELLSRTSFL-----LPKRPRLW--------------------- ------EDARx--------------------------------------- -------------------------------------------------- -------------------------------------RT----------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- K------------------------------------------------- -----------------------------------------ESPH----- ---------CSHWVSA---------------------------------- -------------------------------------------------- -------------------------------------------------- ----THLLQGQAWVQL--GAQKEAISEYSRCLELLFRA------------ ----------------------------xxx-DK---------------E Q----------------------------------------------xx- -------xS----------xxxxxxx------------------------ ------------xxM------------------A---------------- -----------------------LQQL----------------------- -------------------------------------------------- ----QTAALISRGLEWVAL------------------------------- ---------------------------GQDTKALQDFLLSV--------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- --QMCP-------------------------------------------- --------------------GNQDASYH---------------------- -----------------------------LLQTLRRL------------- -------------------------------------------------- --DRRDEATAL---------------------W----------------- -------RRLEAQT-----EL-P----xxNTA----------W------- ------S-----------------------------------------FP LYLETC-------------------------------------------- -------------------------------------------LGWIRPP DRETLCEE----------------------------------------FQ TS------------------------------------------------ ----------------------------xxCD-L---------------- -------- >ENSBMUP00000031274 -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ----------M-----------AxxT------------------------ ----------------------xx-xxxxx-------------------- xVS-------------CLDLWREKNDQLVRQAK-Vx-QD----------- -------------------------------------------------- ------------xSLP---------------------------------- ----MRRQ----------------------------------------QL AQD---------------------------------------------AL EGLRGLLCSL---------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ---------------------R---------------------------- ------G------------------------------------------- ---LPATVSVLP-------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- --------------------------------------------LELTVL CNFITLRAN--LAQGFTEDLAQDIQQGLER-------------------- --------------VLETQG-QLE---ARxEHGLWGL------------- --WDST-------------------------------------------- -------------------------------------------------L RVSSLLPELLPALHHLAG-------------------------------- -------------------------------------------------- -------------------------------------LQA---------- -----------------------------------------------ALW LTTNRLGDLTLL-------------------------------------- -------------------------------------LQTLTV------- ---------------SQ--------S---RAS------------------ --EDMLL-----LLKTWRPPAEE--------------------------- -------------------------------------------------- -------------SGAPLTLQDARGLRDVLL------------------- ------------------------T--------------------AFAYR QGL--------QELITGSL----------------PKALSSLHEAASGLC PRSL------------------------------LVQVYTALGTCLRKMG -------------------------------------------------- ----------------SPQRAL-----LYLVAALKEGSTWGPPLLE---- -------------------------------------------------- ---------------------------ASRLYQQLGNI----------AA EIESLELLVEALSIT----CI---PEA---------------------RQ LL----------------------------------IEVEL--------- -------------------------------------------------- -----------------LLPQPDPASPLHCGT------------------ -------------------------------------------------- -QSQAKYLL-----------------------------------ASRCLQ T------------------------------------------------- -------------------------------------------------- -----GRAAD----------AAEHY------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ----------------------------------------LDL------- -------------------------------------------------- -------------------------------------------------- ---------------LALLL-DSS-------------------------- -------------------------------------------------- -------------------------xPK---------------------- -------------------------------------------------- -----------------------------------F------S------- -----PPPCPP-GPCVPELFLEAAAALIQAGRAQDA-------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ----------------------------------------LTVCE----- -------------------------------------------------- -------------------------------------------------- -------ELLSRTSFL-----LPKRPRLW--------------------- ------EDARx--------------------------------------- -------------------------------------------------- -------------------------------------RT----------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- K------------------------------------------------- -----------------------------------------ESPH----- ---------CSHWVSA---------------------------------- -------------------------------------------------- -------------------------------------------------- ----THLLQGQAWVQL--GAQKEAISEYSRCLELLFRA------------ ----------------------------xxx-DK---------------E Q----------------------------------------------xx- -------xS----------xxxxxxx------------------------ ------------xxM------------------A---------------- -----------------------LQQL----------------------- -------------------------------------------------- ----QTAALISRGLEWVAL------------------------------- ---------------------------GQDTKALQDFLLSV--------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- --QMCP-------------------------------------------- --------------------GNQDASYH---------------------- -----------------------------LLQTLRRL------------- -------------------------------------------------- --DRRDEATAL---------------------W----------------- -------QRLEAQT-----EL-P----xxNTA----------W------- ------S-----------------------------------------LP LYLETC-------------------------------------------- -------------------------------------------LGWIRPP DRETLCEE----------------------------------------FQ TS------------------------------------------------ ----------------------------xxCD-L---------------- -------- >ENSSSCP00000052519 -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ----------M-----------AxxT------------------------ ----------------------xx-xxxxx-------------------- xDS-------------CLDLWREKNDQLVRQAK-Vx-QN----------- -------------------------------------------------- ------------xSLS---------------------------------- ----LRRQ----------------------------------------QL VQD---------------------------------------------VL EGLRGLLHSL---------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ---------------------Q---------------------------- ------G------------------------------------------- ---LPATVSVLP-------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- --------------------------------------------LELTVI CNFITLRAS--LAQGFTEDLAPDIQRGLER-------------------- --------------VLETQE-QQE---ARxEHRLRGL------------- --WDSV-------------------------------------------- -------------------------------------------------L HVSSLLPELLPALHHLAG-------------------------------- -------------------------------------------------- -------------------------------------LQA---------- -----------------------------------------------ALW LSTDRLEDLTLL-------------------------------------- -------------------------------------LQTLNG------- ---------------SE--------S---SAS------------------ --EELLL-----LLKTWRPPVET--------------------------- -------------------------------------------------- -------------SDAPLTLQDARSLRDVLL------------------- ------------------------T--------------------AFAYR QGL--------RELITGSL----------------PRALSSLHEAASGLC PRPV------------------------------LVQVYTALATCLRKMG -------------------------------------------------- ----------------KPQRAL-----LYLVEAVKGESIWGPPLLE---- -------------------------------------------------- ---------------------------ASRLYQQLGNT----------AA EIESLELLVEALSVT----HI---PEA---------------------PQ LL----------------------------------IEVEL--------- -------------------------------------------------- -----------------LLPPPDPASPLHCGT------------------ -------------------------------------------------- -QSQAKYLL-----------------------------------ASRCLQ T------------------------------------------------- -------------------------------------------------- -----RRVED----------AAEHY------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ----------------------------------------LDL------- -------------------------------------------------- -------------------------------------------------- ---------------LALLL-DGS-------------------------- -------------------------------------------------- -------------------------xPK---------------------- -------------------------------------------------- -----------------------------------F------S------- -----PPPCPP-GPCVPEVFLEAAVALIQAGRAQDA-------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ----------------------------------------LTVCE----- -------------------------------------------------- -------------------------------------------------- -------ELLSRTSSL-----LPKRPRLW--------------------- ------EDARx--------------------------------------- -------------------------------------------------- -------------------------------------GT----------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- K------------------------------------------------- -----------------------------------------ESPH----- ---------CSPWISA---------------------------------- -------------------------------------------------- -------------------------------------------------- ----IYLLQGQAWVQL--GAQKEAVSEFSRCLELLFQV------------ ----------------------------xxx-DK---------------E P----------------------------------------------xx- -------xS----------xxxxxxx------------------------ ------------xxV------------------V---------------- -----------------------LQQL----------------------- -------------------------------------------------- ----RAAALISRGLEWVAG------------------------------- ---------------------------GQDNKALQDFLLSV--------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- --QVCP-------------------------------------------- --------------------GNQDASFH---------------------- -----------------------------LLQTLRRL------------- -------------------------------------------------- --DRRDEAIAF---------------------W----------------- -------QRLEAQT-----DL-P----xxNAT----------W------- ------S-----------------------------------------LP LYLETY-------------------------------------------- -------------------------------------------LDWIRPP DREALLEE----------------------------------------FR TSL----------------------------------------------- ----------------------------xxCD-Lx--------------- -------- >ENSSBOP00000011801 -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ----------x-----------xxxx------------------------ ----------------------xxxxx----------------------- --S-------------CLDMWREKNDRLVRQAK-Vx-QN----------- -------------------------------------------------- ------------xSLT---------------------------------- ----LRRQ----------------------------------------QL AQD---------------------------------------------AL EGLGGLLHSL---------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ---------------------Q---------------------------- ------G------------------------------------------- ---LPAAVPVLH-------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- --------------------------------------------LELTVT CNFIILRAS--LAQGFTEDQAQVIQRGLER-------------------- --------------VLETQE-QLG---PRxEQGLKEL------------- --WDSV-------------------------------------------- -------------------------------------------------L HTSSLLPELLPALHRLAG-------------------------------- -------------------------------------------------- -------------------------------------LQA---------- -----------------------------------------------ALW LSTDRLGDLALL-------------------------------------- -------------------------------------LETLNG------- ---------------SQ--------S---GAS------------------ --EDLLL-----LLKTWSLPAEE--------------------------- -------------------------------------------------- -------------LDAPLTLQDAQGLKDVLL------------------- ------------------------T--------------------AFAYR QGL--------QELITGNL----------------DRALSSLHEVASGLC PRPL------------------------------LVQVYTALGSCHRKMG -------------------------------------------------- ----------------NPQRAL-----LYLVAALKEGSAWGPPLLE---- -------------------------------------------------- ---------------------------ASRLYQQLGDT----------TA ELESLELLVEALNVP----CN---SKA---------------------PQ FL----------------------------------IEVEL--------- -------------------------------------------------- -----------------LLPPPDPASPLHCGT------------------ -------------------------------------------------- -QSQAKHVL-----------------------------------ASRCLQ T------------------------------------------------- -------------------------------------------------- -----GRVED----------AAEHY------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ----------------------------------------LDL------- -------------------------------------------------- -------------------------------------------------- ---------------LALLL-DSS-------------------------- -------------------------------------------------- -------------------------xPR---------------------- -------------------------------------------------- -----------------------------------F------S------- -----LPRSHP-GPCMPELFLEAAVALIQAGRAQDA-------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ----------------------------------------LTLCE----- -------------------------------------------------- -------------------------------------------------- -------ELLSHTSSL-----LPKMFRLW--------------------- ------EDARx--------------------------------------- -------------------------------------------------- -------------------------------------GT----------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- K------------------------------------------------- -----------------------------------------ELPY----- ---------CPLWVSA---------------------------------- -------------------------------------------------- -------------------------------------------------- ----THLLQGQAWVQL--GAQKMAVSEFSRCLELLFRA------------ ----------------------------xxx-DK---------------V Q----------------------------------------------xx- -------xS----------xxxxxxx------------------------ ------------xxM------------------A---------------- -----------------------LQQL----------------------- -------------------------------------------------- ----RAAALISRGLEWVAS------------------------------- ---------------------------GQDTKALQDFLLAV--------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- --QMCP-------------------------------------------- --------------------GNRDTYFH---------------------- -----------------------------LLQTLRRL------------- -------------------------------------------------- --DRRDEATAL---------------------W----------------- -------RRLEAQT-----KG-P----xxGAI----------W------- ------S-----------------------------------------LP LYLESY-------------------------------------------- -------------------------------------------LSWIRPS DREALLEE----------------------------------------FQ TSL----------------------------------------------- ---------------------------xxSCD-L---------------- -------- >ENSANAP00000019215 -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ----------x-----------xxxx------------------------ ----------------------xxxxx----------------------- --S-------------CLDLWREKNDRLVRQVK-Vx-QN----------- -------------------------------------------------- ------------xGLT---------------------------------- ----LRRQ----------------------------------------RL AQD---------------------------------------------AL EGLRGLLHSL---------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ---------------------Q---------------------------- ------G------------------------------------------- ---LPAAVPVLP-------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- --------------------------------------------LELTVT CNFIILRAS--LAQGFTEDQVQDIQRGLER-------------------- --------------VLETQE-QLG---PRxEQGLKEL------------- --WHSV-------------------------------------------- -------------------------------------------------L HASSLLPELLSALHCLAG-------------------------------- -------------------------------------------------- -------------------------------------LQA---------- -----------------------------------------------ALW LSTDRLGDLGLL-------------------------------------- -------------------------------------LETLNG------- ---------------SQ--------S---GAS------------------ --EDLLL-----LLKTWSPPAEE--------------------------- -------------------------------------------------- -------------LDVPLTLQDAQGLKDVLL------------------- ------------------------T--------------------AFAYR QGL--------QELITGNL----------------DRALSSLHEVASGLC PRPV------------------------------LVQVYTALGSCHRKMG -------------------------------------------------- ----------------NPQRAL-----LYLVAALKEGSAWGPPLLE---- -------------------------------------------------- ---------------------------ASRLYQQLGDT----------TA ELESLELLVEALNVP----CS---SKA---------------------PQ FL----------------------------------IEVEL--------- -------------------------------------------------- -----------------LLPPPDPASPLHCGT------------------ -------------------------------------------------- -QSQAKHVL-----------------------------------ASRCLQ T------------------------------------------------- -------------------------------------------------- -----GRAED----------AAEHY------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ----------------------------------------LDL------- -------------------------------------------------- -------------------------------------------------- ---------------LALLL-DSS-------------------------- -------------------------------------------------- -------------------------xPR---------------------- -------------------------------------------------- -----------------------------------F------F------- -----LPRSRP-GPCMPELFLEAAVALIQAGRAQDA-------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ----------------------------------------LTLCE----- -------------------------------------------------- -------------------------------------------------- -------ELLSRTSSL-----LPKMSRLW--------------------- ------EDARx--------------------------------------- -------------------------------------------------- -------------------------------------GT----------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- K------------------------------------------------- -----------------------------------------ELPY----- ---------CPLWVSA---------------------------------- -------------------------------------------------- -------------------------------------------------- ----THLLQGQAWVQL--GAQKMAVSEFSRCLELLFRA------------ ----------------------------xxx-DK---------------G Q----------------------------------------------xx- -------xS----------xxxxxxx------------------------ ------------xxV------------------A---------------- -----------------------LQQL----------------------- -------------------------------------------------- ----RAAALISRGLEWVAS------------------------------- ---------------------------GQDTKALQDFLLAM--------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- --QMCP-------------------------------------------- --------------------GNRDTYFH---------------------- -----------------------------LLQTLRRL------------- -------------------------------------------------- --DRRDEATAL---------------------W----------------- -------RRLEAQT-----KG-L----xxGAT----------W------- ------S-----------------------------------------LP LYLESY-------------------------------------------- -------------------------------------------LSWIRPS DREALLEE----------------------------------------FQ TSL----------------------------------------------- ---------------------------xxSCD-L---------------- -------- >ENSCJAP00000072310 -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ----------x-----------xxxx------------------------ ----------------------xxxxx----------------------- --S-------------CLDLWREKNDRLVRQAK-Vx-QN----------- -------------------------------------------------- ------------xGLT---------------------------------- ----LRRQ----------------------------------------QL AQN---------------------------------------------AL EGLRGLLHSL---------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ---------------------Q---------------------------- ------G------------------------------------------- ---LPAAVPVLP-------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- --------------------------------------------LELTVT CNFIILRAS--LAQGFTEDQAQDIQRGLER-------------------- --------------VLETQE-QLG---PRxEQGLKEL------------- --WDSV-------------------------------------------- -------------------------------------------------L HASILLPELLSALHRLAG-------------------------------- -------------------------------------------------- -------------------------------------LQA---------- -----------------------------------------------ALW LSADRLGDLALL-------------------------------------- -------------------------------------LETLNG------- ---------------SQ--------N---GAS------------------ --EDLLL-----LLKTWSPPVEE--------------------------- -------------------------------------------------- -------------LDAPLTLQDAQGLKDVLL------------------- ------------------------T--------------------AFAYR QGL--------QELITGNL----------------DRALSSLHEVASGLC PRPV------------------------------LVQVYTALGSCHRKMG -------------------------------------------------- ----------------NPQRAL-----LYLVAALKEGSAWGPPLLE---- -------------------------------------------------- ---------------------------ASRLYQQLGDT----------TA ELESLELLVEALNVP----CS---SKA---------------------SQ FV----------------------------------IEVEL--------- -------------------------------------------------- -----------------LLPPPDPASPLHCGT------------------ -------------------------------------------------- -QSQAKHVL-----------------------------------ASRCLQ T------------------------------------------------- -------------------------------------------------- -----GRAED----------AAEHY------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ----------------------------------------LDL------- -------------------------------------------------- -------------------------------------------------- ---------------LALLL-DSS-------------------------- -------------------------------------------------- -------------------------xPR---------------------- -------------------------------------------------- -----------------------------------F------F------- -----LPRSRP-GPCMPELFLEAAVALIQAGRAQDA-------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ----------------------------------------LTVCE----- -------------------------------------------------- -------------------------------------------------- -------ELLSRTSSL-----LPKMSRLW--------------------- ------EDARx--------------------------------------- -------------------------------------------------- -------------------------------------GT----------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- K------------------------------------------------- -----------------------------------------ELPY----- ---------CPLWVSA---------------------------------- -------------------------------------------------- -------------------------------------------------- ----THLLQGQAWVQL--GAQKMAVSEFSRCLELLFHA------------ ----------------------------xxx-DK---------------G Q----------------------------------------------xx- -------xS----------xxxxxxx------------------------ ------------xxV------------------A---------------- -----------------------LQQL----------------------- -------------------------------------------------- ----RAAALISRGLEWVDS------------------------------- ---------------------------GQDTKALQDFLLAV--------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- --QMCP-------------------------------------------- --------------------GNQDTYFH---------------------- -----------------------------LLQTLRRL------------- -------------------------------------------------- --NRRDEATAL---------------------W----------------- -------RRLEAQT-----KG-P----xxGAT----------W------- ------S-----------------------------------------LP LYLESY-------------------------------------------- -------------------------------------------LSWIHPS DCEALLEE----------------------------------------FQ TSL----------------------------------------------- ---------------------------xxSCD-L---------------- -------- >ENSCCAP00000033040 -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ----------x-----------xxxx------------------------ ----------------------xxxxx----------------------- --S-------------CLDLWREKNDRLVRQAK-Vx-QN----------- -------------------------------------------------- ------------xGLT---------------------------------- ----LRRQ----------------------------------------QL AQD---------------------------------------------AL EGLRGLLHSL---------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ---------------------Q---------------------------- ------G------------------------------------------- ---LPAAVPVLP-------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- --------------------------------------------LELTVT CNFIILRAS--LAQGFTEDQAQDIQRGLER-------------------- --------------VLETQE-QLG---PRxEQGLKEL------------- --WDCV-------------------------------------------- -------------------------------------------------L RVSSLLPELLSALHRLAG-------------------------------- -------------------------------------------------- -------------------------------------LQA---------- -----------------------------------------------ALW LSADRLGDLALL-------------------------------------- -------------------------------------LETLNG------- ---------------SQ--------S---GAS------------------ --EDRLL-----LLKTWSPPAEE--------------------------- -------------------------------------------------- -------------LDAPLTLQDAQGLKDVLL------------------- ------------------------T--------------------AFAYR QGL--------QELITGNL----------------DRALSSLHEVASGLC PRPV------------------------------LVQVYTALGSCHRKMG -------------------------------------------------- ----------------NPQRAL-----LYLVAALKEGSAWGPPLLE---- -------------------------------------------------- ---------------------------ASRLYQQLGDT----------TA ELESLELLVEALNVP----CS---SKA---------------------PQ FL----------------------------------IEVEL--------- -------------------------------------------------- -----------------LLPPPDPASPLHCGT------------------ -------------------------------------------------- -RSQAKHVL-----------------------------------ASRCLQ T------------------------------------------------- -------------------------------------------------- -----GRAED----------AAEHY------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ----------------------------------------LDL------- -------------------------------------------------- -------------------------------------------------- ---------------LALLL-DSS-------------------------- -------------------------------------------------- -------------------------xPR---------------------- -------------------------------------------------- -----------------------------------F------F------- -----LPRSRP-GPCMPELFLEAAVALIQAGRAQDA-------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ----------------------------------------LTLCE----- -------------------------------------------------- -------------------------------------------------- -------ELLSRTSSL-----LPKISWLW--------------------- ------EDARx--------------------------------------- -------------------------------------------------- -------------------------------------GT----------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- K------------------------------------------------- -----------------------------------------ELPY----- ---------CPLWVSA---------------------------------- -------------------------------------------------- -------------------------------------------------- ----THLLQGQAWVQL--GAPKMAVSEFSRCLELLFRA------------ ----------------------------xxx-DK---------------G Q----------------------------------------------xx- -------xS----------xxxxxxx------------------------ ------------xxA------------------A---------------- -----------------------LQQL----------------------- -------------------------------------------------- ----RAAALISRGLEWVAS------------------------------- ---------------------------GQDTKALQDFLLAV--------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- --QICP-------------------------------------------- --------------------GNRDTYFH---------------------- -----------------------------LLQTLRRL------------- -------------------------------------------------- --DRRDEATAL---------------------W----------------- -------RRLEAQT-----KG-P----xxGAI----------W------- ------S-----------------------------------------LP LYLESY-------------------------------------------- -------------------------------------------LSWIGPS DREALLEE----------------------------------------FQ TSL----------------------------------------------- ---------------------------xxSCD-L---------------- -------- >ENSMFAP00000007563 -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ----------x-----------xxxx------------------------ ----------------------xxxxx----------------------- --S-------------CLDLWREKNDRLVRQAK-Vx-QN----------- -------------------------------------------------- ------------xGLT---------------------------------- ----LRRQ----------------------------------------QL AQD---------------------------------------------AL EGLRGLLHSL---------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ---------------------Q---------------------------- ------G------------------------------------------- ---LPAAVPVLP-------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- --------------------------------------------LELTVI CNFIILRAS--LAQGFTEDQAQDIQRGLER-------------------- --------------VLETQE-QRG---PRxEQGLREL------------- --WDSA-------------------------------------------- -------------------------------------------------L RASCLLPELLSALHRLAG-------------------------------- -------------------------------------------------- -------------------------------------LQA---------- -----------------------------------------------ALW LSADRLGDLALL-------------------------------------- -------------------------------------LETLND------- ---------------SQ--------S---GAS------------------ --EDLLL-----LLKTWSPPAEE--------------------------- -------------------------------------------------- -------------LDAPLTLQDAQGLKDVLL------------------- ------------------------T--------------------AFAYR RGL--------QELITGNP----------------EKALSSLHEVASGLC PRPV------------------------------LVQVYTALGSCHRKMG -------------------------------------------------- ----------------NPQRAL-----LYLVAALKEGSAWGPPLLE---- -------------------------------------------------- ---------------------------ASRLYQQLGDT----------TA ELESLELLVEALNVP----YS---SKA---------------------PP FL----------------------------------IEVEL--------- -------------------------------------------------- -----------------LLPPPDLASPLHCGT------------------ -------------------------------------------------- -QSQAKHVL-----------------------------------ASRCLQ T------------------------------------------------- -------------------------------------------------- -----GRAED----------AAEHY------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ----------------------------------------LDL------- -------------------------------------------------- -------------------------------------------------- ---------------LALLL-DSS-------------------------- -------------------------------------------------- -------------------------xPR---------------------- -------------------------------------------------- -----------------------------------F------S------- -----PPPSPP-GPCMPEVFLEAAVALIQAGRAQDA-------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ----------------------------------------LTLCE----- -------------------------------------------------- -------------------------------------------------- -------ELLSRTSSL-----LPKMSRLW--------------------- ------ENARx--------------------------------------- -------------------------------------------------- -------------------------------------GT----------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- K------------------------------------------------- -----------------------------------------ELPY----- ---------CPLWVSA---------------------------------- -------------------------------------------------- -------------------------------------------------- ----THLLQGQAWVQL--GAQKVAISEFSRCLELLFRT------------ ----------------------------xxx-EK---------------E Q----------------------------------------------xx- -------xS----------xxxxxxx------------------------ ------------xxV------------------A---------------- -----------------------LQQL----------------------- -------------------------------------------------- ----RAAALISRGLEWVAS------------------------------- ---------------------------GQDTKALQDFLLGV--------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- --QMCP-------------------------------------------- --------------------GNRDTYFH---------------------- -----------------------------LLQTLKRL------------- -------------------------------------------------- --DRRDEATAL---------------------W----------------- -------WRLEAQT-----KG-P----xxDAT----------W------- ------S-----------------------------------------LP LYLESY-------------------------------------------- -------------------------------------------LSWIRPS DRDAFLEE----------------------------------------FR TSL----------------------------------------------- ---------------------------xxSCD-L---------------- -------- >ENSCATP00000011352 -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ----------x-----------xxxx------------------------ ----------------------xxxxx----------------------- --S-------------CLDLWREKNDRLVRQAK-Vx-QN----------- -------------------------------------------------- ------------xGLT---------------------------------- ----LRRQ----------------------------------------QL AQD---------------------------------------------AL EGLRGLLHSL---------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ---------------------Q---------------------------- ------G------------------------------------------- ---LPAAVPVLP-------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- --------------------------------------------LELTVI CNFIILRAS--LAQGFTEDQAQDIQRGLER-------------------- --------------VLETQE-QRG---PRxEQGLREL------------- --WDSA-------------------------------------------- -------------------------------------------------L RASCLLPELLSALHRLAG-------------------------------- -------------------------------------------------- -------------------------------------LQA---------- -----------------------------------------------ALW LSADRLGDLALL-------------------------------------- -------------------------------------LETLND------- ---------------SQ--------S---GAS------------------ --EDLLL-----LLKTWSPPAEE--------------------------- -------------------------------------------------- -------------LDAPLTLQDAQGLKDVLL------------------- ------------------------T--------------------AFAYR RGL--------QELITGNP----------------EKALSSLHEVASGLC PRPV------------------------------LVQVYTALGSCHRKMG -------------------------------------------------- ----------------NPQRAL-----LYLVAALKEGSAWGPPLLE---- -------------------------------------------------- ---------------------------ASRLYQQLGDT----------TA ELESLELLVEALNVP----YS---SKA---------------------PP FL----------------------------------IEVEL--------- -------------------------------------------------- -----------------LLPPPDLASPLHCGT------------------ -------------------------------------------------- -QSQAKHVL-----------------------------------ASRCLQ T------------------------------------------------- -------------------------------------------------- -----GRAED----------AAEHY------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ----------------------------------------LDL------- -------------------------------------------------- -------------------------------------------------- ---------------LALLL-DSS-------------------------- -------------------------------------------------- -------------------------xPR---------------------- -------------------------------------------------- -----------------------------------F------S------- -----PPPSPP-GPCMPEVFLEAAVALIQAGRAQDA-------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ----------------------------------------LTLCE----- -------------------------------------------------- -------------------------------------------------- -------ELLSRTSSL-----LPKMSRLW--------------------- ------ENARx--------------------------------------- -------------------------------------------------- -------------------------------------GT----------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- K------------------------------------------------- -----------------------------------------ELPY----- ---------CPLWVSA---------------------------------- -------------------------------------------------- -------------------------------------------------- ----THLLQGQAWVQL--GAQKVAISEFSRCLELLFRT------------ ----------------------------xxx-EK---------------E Q----------------------------------------------xx- -------xS----------xxxxxxx------------------------ ------------xxV------------------A---------------- -----------------------LQQL----------------------- -------------------------------------------------- ----RAAALISRGLEWVAS------------------------------- ---------------------------GQDTKALQDFLLGV--------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- --QMCP-------------------------------------------- --------------------GNRDTYFH---------------------- -----------------------------LLQTLKRL------------- -------------------------------------------------- --DRRDEATAL---------------------W----------------- -------WRLEAPT-----KG-P----xxDAT----------W------- ------S-----------------------------------------LP LYLESY-------------------------------------------- -------------------------------------------LSWIRPS DRDAFLEE----------------------------------------FR TSL----------------------------------------------- ---------------------------xxSCD-L---------------- -------- >ENSTGEP00000010695 -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ----------x-----------xxxx------------------------ ----------------------xxxxx----------------------- --S-------------CLDLWREKNDRLVRQAK-Vx-QN----------- -------------------------------------------------- ------------xGLT---------------------------------- ----LRRQ----------------------------------------QL AQD---------------------------------------------AL EGLRGLLHSL---------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ---------------------Q---------------------------- ------G------------------------------------------- ---LPAAVPVLP-------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- --------------------------------------------LELTVI CNFIILRAS--LAQGFTEDQAQDIQRGLER-------------------- --------------VLETQE-QRG---PRxEQGLREL------------- --WDSA-------------------------------------------- -------------------------------------------------L RASCLLPELLSALHRLAG-------------------------------- -------------------------------------------------- -------------------------------------LQA---------- -----------------------------------------------ALW LSADRLGDLALL-------------------------------------- -------------------------------------LETLND------- ---------------SQ--------S---GAS------------------ --EDLLL-----LLKTWSPPAEE--------------------------- -------------------------------------------------- -------------LDAPLTLQDAQGLKDVLL------------------- ------------------------T--------------------AFAYR RGL--------QELITGNP----------------EKALSSLHEVASGLC PRPV------------------------------LVQVYTALGSCHRKMG -------------------------------------------------- ----------------NPQRAL-----LYLVAALKEGSAWGPPLLE---- -------------------------------------------------- ---------------------------ASRLYQQLGDT----------TA ELESLELLVEALNVP----YS---SKT---------------------PP FL----------------------------------IEVEL--------- -------------------------------------------------- -----------------LLPPPDLASPLHCGT------------------ -------------------------------------------------- -QSQAKHVL-----------------------------------ASRCLQ M------------------------------------------------- -------------------------------------------------- -----GRAED----------AAEHY------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ----------------------------------------LDL------- -------------------------------------------------- -------------------------------------------------- ---------------LALLL-DSS-------------------------- -------------------------------------------------- -------------------------xPR---------------------- -------------------------------------------------- -----------------------------------F------S------- -----PPPSPP-GPCMPEVFLEAAVALIQAGRAQDA-------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ----------------------------------------LTLCE----- -------------------------------------------------- -------------------------------------------------- -------ELLRRTSSL-----LPKMSRLW--------------------- ------ENARx--------------------------------------- -------------------------------------------------- -------------------------------------GT----------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- K------------------------------------------------- -----------------------------------------ELPY----- ---------CPLWVSA---------------------------------- -------------------------------------------------- -------------------------------------------------- ----THLLQGQAWVQL--GAQKVAISEFSRCLELLFRT------------ ----------------------------xxx-EK---------------E K----------------------------------------------xx- -------xS----------xxxxxxx------------------------ ------------xxV------------------A---------------- -----------------------LQQL----------------------- -------------------------------------------------- ----RAAALISRGLEWVAS------------------------------- ---------------------------GQDTKALQDFLLGV--------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- --QMCP-------------------------------------------- --------------------GNRDTYFH---------------------- -----------------------------LLQTLKRL------------- -------------------------------------------------- --DRRDEATAL---------------------W----------------- -------WRLEAQT-----KG-P----xxDAT----------W------- ------S-----------------------------------------LP LYLESY-------------------------------------------- -------------------------------------------LSWIRPS DRDAFLEE----------------------------------------FR TSL----------------------------------------------- ---------------------------xxSCD-L---------------- -------- >ENSPANP00000019118 -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ----------x-----------xxxx------------------------ ----------------------xxxxx----------------------- --S-------------CLDLWREKNDRLVRQAK-Vx-QN----------- -------------------------------------------------- ------------xGLT---------------------------------- ----LRRQ----------------------------------------QL AQD---------------------------------------------AL EGLRGLLHSL---------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ---------------------Q---------------------------- ------G------------------------------------------- ---LPAAVPVLP-------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- --------------------------------------------LELTVI CNFIILRAS--LAQGFTEDQAQDIQRGLER-------------------- --------------VLETQE-QRG---PRxEQGLREL------------- --WDSA-------------------------------------------- -------------------------------------------------L RASCLLPELLSALHRLAG-------------------------------- -------------------------------------------------- -------------------------------------LQA---------- -----------------------------------------------ALW LSADRLGDLALL-------------------------------------- -------------------------------------LETLND------- ---------------SQ--------S---GAS------------------ --EDLLL-----LLKTWSPPAEE--------------------------- -------------------------------------------------- -------------LDAPLTLQDAQGLKDVLL------------------- ------------------------T--------------------AFAYR RGL--------QELITGNP----------------EKALSSLHEVASGLC PRPV------------------------------LVQVYTALGSCHRKMG -------------------------------------------------- ----------------NPQRAL-----LYLVAALKEGSAWGPPLLE---- -------------------------------------------------- ---------------------------ASRLYQQLGDT----------TA ELESLELLVEALNVP----YS---SKA---------------------PP FL----------------------------------IEVEL--------- -------------------------------------------------- -----------------LLPPPDLASPLHCGT------------------ -------------------------------------------------- -QSQAKHVL-----------------------------------ASRCLQ M------------------------------------------------- -------------------------------------------------- -----GRAED----------AAEHY------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ----------------------------------------LDL------- -------------------------------------------------- -------------------------------------------------- ---------------LALLL-DSS-------------------------- -------------------------------------------------- -------------------------xPR---------------------- -------------------------------------------------- -----------------------------------F------S------- -----PPPSPP-GPCMPEVFLEAAVALIQAGRAQDA-------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ----------------------------------------LTLCE----- -------------------------------------------------- -------------------------------------------------- -------ELLRRTSSL-----LPKMSRLW--------------------- ------ENARx--------------------------------------- -------------------------------------------------- -------------------------------------GT----------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- K------------------------------------------------- -----------------------------------------ELPY----- ---------CPLWVSA---------------------------------- -------------------------------------------------- -------------------------------------------------- ----THLLQGQAWVQL--GAQKVAISEFSRCLELLFRT------------ ----------------------------xxx-EK---------------E Q----------------------------------------------xx- -------xS----------xxxxxxx------------------------ ------------xxV------------------A---------------- -----------------------LQQL----------------------- -------------------------------------------------- ----RAAALISRGLEWVAS------------------------------- ---------------------------GQDTKALQDFLLGV--------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- --QMCP-------------------------------------------- --------------------GNRDTYFH---------------------- -----------------------------LLQTLKRL------------- -------------------------------------------------- --DRRDEATAL---------------------W----------------- -------WRLEAQT-----KG-P----xxDAT----------W------- ------S-----------------------------------------LP LYLESY-------------------------------------------- -------------------------------------------LSWIRPS DRDAFLEE----------------------------------------FR TSL----------------------------------------------- ---------------------------xxSCD-L---------------- -------- >ENSMNEP00000038617 -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ----------x-----------xxxx------------------------ ----------------------xxxxx----------------------- --S-------------CLDLWREKNDRLVRQAK-Vx-QN----------- -------------------------------------------------- ------------xGLT---------------------------------- ----LRRQ----------------------------------------QL AQD---------------------------------------------AL EGLRGLLHSL---------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ---------------------Q---------------------------- ------G------------------------------------------- ---LPAAVPVLP-------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- --------------------------------------------LELTVI CNFIILRAS--LAQGFTEDQAQDIQRGLER-------------------- --------------VLETQE-QRG---PRxEQGLREL------------- --WDSA-------------------------------------------- -------------------------------------------------L RASCLLPELLSALHLLAG-------------------------------- -------------------------------------------------- -------------------------------------LQA---------- -----------------------------------------------ALW LSADRLGDLALL-------------------------------------- -------------------------------------LETLND------- ---------------SQ--------S---GAS------------------ --EDLLL-----LLKTWSPPAEE--------------------------- -------------------------------------------------- -------------LDAPLTLQDAQGLKDVLL------------------- ------------------------T--------------------AFAYR RGL--------QELITGNP----------------EKALSSLHEVASGLC PRPV------------------------------LVQVYTALGSCHRKMG -------------------------------------------------- ----------------NPQRAL-----LYLVAALKEGSAWGPPLLE---- -------------------------------------------------- ---------------------------ASRLYQQLGDT----------TA ELESLELLVEALNVP----YS---SKA---------------------PP FL----------------------------------IEVEL--------- -------------------------------------------------- -----------------LLPPPDLASPLHCGT------------------ -------------------------------------------------- -QSQAKHVL-----------------------------------ASRCLQ T------------------------------------------------- -------------------------------------------------- -----GRAED----------AAEHY------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ----------------------------------------LDL------- -------------------------------------------------- -------------------------------------------------- ---------------LALLL-DSS-------------------------- -------------------------------------------------- -------------------------xPR---------------------- -------------------------------------------------- -----------------------------------F------S------- -----PPPSPP-GPCMPEVFLEAAVALIQAGRAQDA-------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ----------------------------------------LTLCE----- -------------------------------------------------- -------------------------------------------------- -------ELLSRTSSL-----LPKMSWLW--------------------- ------ENARx--------------------------------------- -------------------------------------------------- -------------------------------------GT----------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- K------------------------------------------------- -----------------------------------------ELPY----- ---------CPLWVSA---------------------------------- -------------------------------------------------- -------------------------------------------------- ----THLLQGQAWVQL--GAQKVAISEFSRCLELLFRT------------ ----------------------------xxx-EK---------------E Q----------------------------------------------xx- -------xS----------xxxxxxx------------------------ ------------xxV------------------A---------------- -----------------------LQQL----------------------- -------------------------------------------------- ----RAAALISRGLEWVAS------------------------------- ---------------------------GQDTKALQDFLLGV--------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- --QMCP-------------------------------------------- --------------------GNRDTYFH---------------------- -----------------------------LLQTLKRL------------- -------------------------------------------------- --DRRDEATAL---------------------W----------------- -------WRLEAQT-----KG-P----xxDAT----------W------- ------S-----------------------------------------LP LYLESY-------------------------------------------- -------------------------------------------LSWIRPS DRDAFLEE----------------------------------------FR TSL----------------------------------------------- ---------------------------xxSCD-L---------------- -------- >ENSMLEP00000005135 -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ----------x-----------xxxx------------------------ ----------------------xxxxx----------------------- --S-------------CLELWREKNDRLVRQAK-Vx-QN----------- -------------------------------------------------- ------------xGLT---------------------------------- ----LRRQ----------------------------------------QL AQD---------------------------------------------AL EGLRGLLHSL---------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ---------------------Q---------------------------- ------G------------------------------------------- ---LPAAVPVLP-------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- --------------------------------------------LELTVI CNFIILRAS--LAQGFTEDQAQDIQRGLER-------------------- --------------VLETQE-QRG---PRxEQGLREL------------- --WDSA-------------------------------------------- -------------------------------------------------L RASCLLPELLSPLHRLAG-------------------------------- -------------------------------------------------- -------------------------------------LQA---------- -----------------------------------------------ALW LSADRLGDLALL-------------------------------------- -------------------------------------LETLND------- ---------------SQ--------S---GAS------------------ --EDLLL-----LLKTWSPPAEE--------------------------- -------------------------------------------------- -------------LDAPLTLQDAQGLKDVLL------------------- ------------------------T--------------------AFAYR RGL--------QELITGNP----------------EKALSSLHEVASGLC PRPV------------------------------LVQVYTALGSCHRKMG -------------------------------------------------- ----------------NPQRAL-----LYLVAALKEGSAWGPPLLE---- -------------------------------------------------- ---------------------------ASRLYQQLGDT----------TA ELESLELLVEALNVP----YS---SKA---------------------PP LL----------------------------------IEVEL--------- -------------------------------------------------- -----------------LLPPPDLASPLHCGT------------------ -------------------------------------------------- -QSQAKHVL-----------------------------------ASRCLQ T------------------------------------------------- -------------------------------------------------- -----GRAED----------AAEHY------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ----------------------------------------LDL------- -------------------------------------------------- -------------------------------------------------- ---------------LALLL-DSS-------------------------- -------------------------------------------------- -------------------------xPR---------------------- -------------------------------------------------- -----------------------------------F------S------- -----PPPSPP-GPCMPEVFLEAAVALIQAGRAQDA-------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ----------------------------------------LTLCE----- -------------------------------------------------- -------------------------------------------------- -------ELLSRTSSL-----LPKMSRLW--------------------- ------ENARx--------------------------------------- -------------------------------------------------- -------------------------------------GT----------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- K------------------------------------------------- -----------------------------------------ELPY----- ---------CPLWVSA---------------------------------- -------------------------------------------------- -------------------------------------------------- ----THLLQGQAWVQL--GAQKVAISEFSRCLELLFRT------------ ----------------------------xxx-EK---------------E Q----------------------------------------------xx- -------xS----------xxxxxxx------------------------ ------------xxV------------------A---------------- -----------------------LQQL----------------------- -------------------------------------------------- ----RAAALISRGLEWVAS------------------------------- ---------------------------GQDTKALQDFLLGV--------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- --QMCP-------------------------------------------- --------------------GNRDTYFH---------------------- -----------------------------LLQTLKRL------------- -------------------------------------------------- --DRRDEATAL---------------------W----------------- -------WRLEAQT-----KG-P----xxDAT----------W------- ------S-----------------------------------------LP LYLESY-------------------------------------------- -------------------------------------------LSWIRPS DRDAFLEE----------------------------------------FR TSL----------------------------------------------- ---------------------------xxSCD-L---------------- -------- >ENSCSAP00000006494 -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ----------x-----------xxxx------------------------ ----------------------xxxxx----------------------- --N-------------CLDLWREKNDRLVRQAK-Vx-QN----------- -------------------------------------------------- ------------xGLT---------------------------------- ----LRRL----------------------------------------QL AQD---------------------------------------------AL EGLRGLLHSL---------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ---------------------Q---------------------------- ------G------------------------------------------- ---LPAAVPVLP-------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- --------------------------------------------LELTVI CNFIILRAS--LAQGFTEDQAQDIQRGLER-------------------- --------------VLETQE-QQG---PRxEQGLREL------------- --WDSA-------------------------------------------- -------------------------------------------------L RASCLLPELLSALHRLAG-------------------------------- -------------------------------------------------- -------------------------------------LQA---------- -----------------------------------------------ALW LSADRLGDLALL-------------------------------------- -------------------------------------LETLND------- ---------------SQ--------S---GAS------------------ --EDLLL-----LLKTWSPPAEE--------------------------- -------------------------------------------------- -------------LDAPLTLQDAQGLKDVLL------------------- ------------------------T--------------------AFAYR RGL--------QELITGNP----------------DKALSSLHEVASGLC PRPV------------------------------LVQVYTALGSCHRKMG -------------------------------------------------- ----------------NPQRAL-----LYLVAALKEGSAWGPPLLE---- -------------------------------------------------- ---------------------------ASRLYRQLGDT----------TA ELESLELLVEALNVP----YS---SKA---------------------PP FL----------------------------------IEVEL--------- -------------------------------------------------- -----------------LLPPPDLASPLHCGT------------------ -------------------------------------------------- -QSQAKHVL-----------------------------------ASRCLQ T------------------------------------------------- -------------------------------------------------- -----GRAED----------AAEHY------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ----------------------------------------LDL------- -------------------------------------------------- -------------------------------------------------- ---------------LALLL-DSS-------------------------- -------------------------------------------------- -------------------------xPR---------------------- -------------------------------------------------- -----------------------------------F------S------- -----PPPSPP-GPCMPEVFLEAAVALIQAGRAQDA-------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ----------------------------------------LTLCE----- -------------------------------------------------- -------------------------------------------------- -------ELFSRTSSL-----LPKMSRLW--------------------- ------EDARx--------------------------------------- -------------------------------------------------- -------------------------------------GT----------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- K------------------------------------------------- -----------------------------------------ELPY----- ---------CPLWVSA---------------------------------- -------------------------------------------------- -------------------------------------------------- ----THLLQGQAWVQL--GAQKVAISEFSRCLELLFRT------------ ----------------------------xxx-EK---------------E Q----------------------------------------------xx- -------xS----------xxxxxxx------------------------ ------------xxV------------------A---------------- -----------------------LQQL----------------------- -------------------------------------------------- ----RAAALISRGLEWVAS------------------------------- ---------------------------GQDTKALQDFLLGV--------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- --QMCP-------------------------------------------- --------------------GNRDTYFH---------------------- -----------------------------LLQTLKRL------------- -------------------------------------------------- --DRRDEATAL---------------------W----------------- -------WRLEAQT-----EG-P----xxDAT----------W------- ------S-----------------------------------------LP LYLESY-------------------------------------------- -------------------------------------------LSWIRPS DRDAFLEE----------------------------------------FR TSL----------------------------------------------- ---------------------------xxSCD-L---------------- -------- >ENSPTEP00000016850 -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ----------x-----------xxxx------------------------ ----------------------xxxxx----------------------- --S-------------CLDLWREKNDRLVRQAK-Vx-QN----------- -------------------------------------------------- ------------xDLT---------------------------------- ----LRRR----------------------------------------QL AQD---------------------------------------------AL EGLRGLLHSL---------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ---------------------Q---------------------------- ------G------------------------------------------- ---LPAAVPVLP-------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- --------------------------------------------LELTVI CNFIILRAS--LAQGFTEDQAQDIQRGLER-------------------- --------------VLETQE-QQG---PRxEQGLREL------------- --WDSA-------------------------------------------- -------------------------------------------------L RASCLLPELLSALHRLAG-------------------------------- -------------------------------------------------- -------------------------------------LQA---------- -----------------------------------------------ALW LSADRLGDLALL-------------------------------------- -------------------------------------LETLND------- ---------------SQ--------S---GAS------------------ --EDLLL-----LLKTWSPPSEE--------------------------- -------------------------------------------------- -------------LDAPLTLQDAQGLKDVLL------------------- ------------------------T--------------------AFAYR RGL--------QELITGNP----------------EKALSSLHEVASGPC PRPV------------------------------LVQVYTALGSCHRKMG -------------------------------------------------- ----------------NPQRAL-----LYLVAALKEGSAWGPPLLE---- -------------------------------------------------- ---------------------------ASKLYQQLGDT----------TA ELESLELLVEALNVP----YS---SKS---------------------PQ FL----------------------------------IEVEL--------- -------------------------------------------------- -----------------LLPPPDLASPLHCGT------------------ -------------------------------------------------- -QSQAKHIL-----------------------------------ASRCLQ T------------------------------------------------- -------------------------------------------------- -----GRAED----------AAEHY------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ----------------------------------------LDL------- -------------------------------------------------- -------------------------------------------------- ---------------LALLL-DSS-------------------------- -------------------------------------------------- -------------------------xPR---------------------- -------------------------------------------------- -----------------------------------F------S------- -----PPPSPP-GPCMPEVFLEAAVALIQAGRAQDA-------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ----------------------------------------LTLCE----- -------------------------------------------------- -------------------------------------------------- -------ELLSRTSSL-----LPKMSRLW--------------------- ------EDARx--------------------------------------- -------------------------------------------------- -------------------------------------GT----------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- K------------------------------------------------- -----------------------------------------ELPY----- ---------CPLWVSA---------------------------------- -------------------------------------------------- -------------------------------------------------- ----THLLQGQAWVQL--GAQKVAISEFSRCLELLFRA------------ ----------------------------xxx-EK---------------E K----------------------------------------------xx- -------xS----------xxxxxxx------------------------ ------------xxV------------------A---------------- -----------------------LQQL----------------------- -------------------------------------------------- ----RAAALISRGLEWVAS------------------------------- ---------------------------GQDTKALQDFLLGV--------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- --QMCP-------------------------------------------- --------------------GNGDTYFH---------------------- -----------------------------LLQTLKRL------------- -------------------------------------------------- --DRRDEATAL---------------------W----------------- -------WRLEAQT-----KG-P----xxDAT----------W------- ------S-----------------------------------------LP LYLESY-------------------------------------------- -------------------------------------------LSWIRPS DRDAFLEE----------------------------------------FR TSL----------------------------------------------- ---------------------------xxSCD-L---------------- -------- >ENSRBIP00000018766 -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ----------x-----------xxxx------------------------ ----------------------xxxxx----------------------- --S-------------CLDLWREKNDRLVRQAK-Vx-QN----------- -------------------------------------------------- ------------xDLT---------------------------------- ----LRRR----------------------------------------QL AQD---------------------------------------------AL EGLRGLLHSL---------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ---------------------Q---------------------------- ------G------------------------------------------- ---LPAAVPVLP-------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- --------------------------------------------LELTVI CNFIILRAS--LAQGFTEDQAQDIQRGLER-------------------- --------------VLETQE-QRG---PRxEQGLREL------------- --WDSA-------------------------------------------- -------------------------------------------------L RASCLLPELLSALHRLAG-------------------------------- -------------------------------------------------- -------------------------------------LQA---------- -----------------------------------------------ALW LSADRLGDLALL-------------------------------------- -------------------------------------LETLND------- ---------------SQ--------S---GAS------------------ --EDLLL-----LLKTWSPPAEE--------------------------- -------------------------------------------------- -------------LDAPLTLQDAQGLKDVLL------------------- ------------------------T--------------------AFTYR RGL--------QELITGNP----------------DKALSSLHEVASGLC PRPV------------------------------LVQVYTALGSCHRKMG -------------------------------------------------- ----------------NPQRAL-----LYLVAALKEGSAWGPPLLE---- -------------------------------------------------- ---------------------------ASRLYQQLGDT----------PA ELESLELLVEALNVP----YS---SKA---------------------PQ FL----------------------------------IEVEL--------- -------------------------------------------------- -----------------LLPPPDLASPLHCGT------------------ -------------------------------------------------- -QSQAKHIL-----------------------------------ASRCLQ T------------------------------------------------- -------------------------------------------------- -----GRAED----------AAEHY------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ----------------------------------------LDL------- -------------------------------------------------- -------------------------------------------------- ---------------LALLL-DSS-------------------------- -------------------------------------------------- -------------------------xPR---------------------- -------------------------------------------------- -----------------------------------F------S------- -----PPPSPP-GPCMPEVFLEAAVALIQAGRAQDA-------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ----------------------------------------LTLCE----- -------------------------------------------------- -------------------------------------------------- -------ELLSRTSSL-----LPKMSRLW--------------------- ------EDARx--------------------------------------- -------------------------------------------------- -------------------------------------GT----------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- K------------------------------------------------- -----------------------------------------ELPY----- ---------CPLWVSA---------------------------------- -------------------------------------------------- -------------------------------------------------- ----THLLQGQAWVQL--GAQKVAISEFSRCLELLFRT------------ ----------------------------xxx-EK---------------E Q----------------------------------------------xx- -------xS----------xxxxxxx------------------------ ------------xxV------------------A---------------- -----------------------LQQL----------------------- -------------------------------------------------- ----RAAALISRGLEWVAS------------------------------- ---------------------------GQDTKALQDFLLGV--------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- --QMCP-------------------------------------------- --------------------GNGDTYFH---------------------- -----------------------------LLQTLKRL------------- -------------------------------------------------- --DRRDEATAL---------------------W----------------- -------WRLEAQT-----KG-P----xxDAM----------W------- ------S-----------------------------------------LP LYLESY-------------------------------------------- -------------------------------------------LSWIRPS DRDAFLEE----------------------------------------FR TSL----------------------------------------------- ---------------------------xxSCD-L---------------- -------- >ENSRROP00000036166 -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ----------x-----------xxxx------------------------ ----------------------xxxxx----------------------- --S-------------CLDLWREKNDRLVRQAK-Vx-QN----------- -------------------------------------------------- ------------xDLT---------------------------------- ----LRRR----------------------------------------QL AQD---------------------------------------------AL EGLRGLLHSL---------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ---------------------Q---------------------------- ------G------------------------------------------- ---LPAAVPVLP-------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- --------------------------------------------LELTVI CNFIILRAS--LAQGFTEDQAQDIQRGLER-------------------- --------------VLETQE-QRG---PRxEQGLREL------------- --WDSA-------------------------------------------- -------------------------------------------------L RASCLLPELLSALHRLAG-------------------------------- -------------------------------------------------- -------------------------------------LQA---------- -----------------------------------------------ALW LSADRLGDLALL-------------------------------------- -------------------------------------LETLND------- ---------------SQ--------S---GAS------------------ --EDLLL-----LLKTWSPPAEE--------------------------- -------------------------------------------------- -------------LDAPLTLQDAQGLKDVLL------------------- ------------------------T--------------------AFAYR RGL--------QELITGNP----------------DKALSSLHEVASGLC PRPV------------------------------LVQVYTALGSCHRKMG -------------------------------------------------- ----------------NPQRAL-----LYLVAALKEGSAWGPPLLE---- -------------------------------------------------- ---------------------------ASRLYQQLGDT----------PA ELESLELLVEALNVP----YS---SKA---------------------PQ FL----------------------------------IEVEL--------- -------------------------------------------------- -----------------LLPPPDLASPLHCGT------------------ -------------------------------------------------- -QSQAKHIL-----------------------------------ASRCLQ T------------------------------------------------- -------------------------------------------------- -----GRAED----------AAEHY------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ----------------------------------------LDL------- -------------------------------------------------- -------------------------------------------------- ---------------LALLL-DSS-------------------------- -------------------------------------------------- -------------------------xPR---------------------- -------------------------------------------------- -----------------------------------F------S------- -----PPPSPP-GPCMPEVFLEAAVALIQAGRAQDA-------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ----------------------------------------LTLCE----- -------------------------------------------------- -------------------------------------------------- -------ELLSRTSSL-----LPKMSRLW--------------------- ------EDARx--------------------------------------- -------------------------------------------------- -------------------------------------GT----------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- K------------------------------------------------- -----------------------------------------ELPY----- ---------CPLWVSA---------------------------------- -------------------------------------------------- -------------------------------------------------- ----THLLQGQAWVQL--GAQKVAISEFSRCLELLFRT------------ ----------------------------xxx-EK---------------E Q----------------------------------------------xx- -------xS----------xxxxxxx------------------------ ------------xxV------------------A---------------- -----------------------LQQL----------------------- -------------------------------------------------- ----RAAALISRGLEWVAS------------------------------- ---------------------------GQDTKALQDFLLGV--------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- --QMCP-------------------------------------------- --------------------GNGDTYFH---------------------- -----------------------------LLQTLKRL------------- -------------------------------------------------- --DRRDEATAL---------------------W----------------- -------WRLEAQT-----KG-P----xxDAM----------W------- ------S-----------------------------------------LP LYLESY-------------------------------------------- -------------------------------------------LSWIRPS DRDAFLEE----------------------------------------FR TSL----------------------------------------------- ---------------------------xxSCD-L---------------- -------- >ENSCANP00000022651 -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ----------x-----------xxxx------------------------ ----------------------xxxxx----------------------- --S-------------CLDLWREKNDRLVRQAK-Vx-QN----------- -------------------------------------------------- ------------xDLT---------------------------------- ----LRRR----------------------------------------QV AQD---------------------------------------------AL EGLRGLLHSL---------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ---------------------Q---------------------------- ------G------------------------------------------- ---LPAAVPVLP-------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- --------------------------------------------LELTVI CNFIILRAS--LAQGFTEDQAQDIQRGLER-------------------- --------------VLETQE-QQG---PRxEQGLREL------------- --WDSA-------------------------------------------- -------------------------------------------------L RASCLLPELLSALHRLAG-------------------------------- -------------------------------------------------- -------------------------------------LQA---------- -----------------------------------------------ALW LSADRLGDLALL-------------------------------------- -------------------------------------LETLND------- ---------------SQ--------S---GAS------------------ --EDLLL-----LLKTWSPPSEE--------------------------- -------------------------------------------------- -------------LDAPLTLQDAQGLKDVLL------------------- ------------------------T--------------------AFAYR RGL--------QELITGNP----------------DKALSSLHEVASGLC PRPV------------------------------LVQVYTALGSCHRKMG -------------------------------------------------- ----------------NPQRAL-----LYLVAALKEGSAWGPPLLE---- -------------------------------------------------- ---------------------------ASRLYQQLGDT----------TA ELESLELLVEALNVP----YS---SKS---------------------PQ FL----------------------------------IEVEL--------- -------------------------------------------------- -----------------LLPPPDLASPLHCGT------------------ -------------------------------------------------- -RSQAKHIL-----------------------------------ASRCLQ T------------------------------------------------- -------------------------------------------------- -----GRAED----------AAEHY------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ----------------------------------------LDL------- -------------------------------------------------- -------------------------------------------------- ---------------LALLL-DSS-------------------------- -------------------------------------------------- -------------------------xPR---------------------- -------------------------------------------------- -----------------------------------F------S------- -----PPPSPP-GPCMPEVFLEAAVALIQAGRAQDA-------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ----------------------------------------LTVCE----- -------------------------------------------------- -------------------------------------------------- -------ELLSRTSSL-----LPKMSRLW--------------------- ------EDARx--------------------------------------- -------------------------------------------------- -------------------------------------GT----------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- K------------------------------------------------- -----------------------------------------ELPY----- ---------CPLWVSA---------------------------------- -------------------------------------------------- -------------------------------------------------- ----THLLQGQAWVQL--GAQKVAISEFSRCLELLFRT------------ ----------------------------xxx-EK---------------E Q----------------------------------------------xx- -------xS----------xxxxxxx------------------------ ------------xxV------------------A---------------- -----------------------LQQL----------------------- -------------------------------------------------- ----RAAALISRGLEWVAS------------------------------- ---------------------------GQDTKALQDFLLGV--------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- --QMCP-------------------------------------------- --------------------GNGDTYFH---------------------- -----------------------------LLQTLKRL------------- -------------------------------------------------- --DRRDEATAL---------------------W----------------- -------WRLEAQT-----KG-P----xxDAT----------W------- ------S-----------------------------------------LP LYLESY-------------------------------------------- -------------------------------------------LSWIRPS DRDAFLEE----------------------------------------FQ TSL----------------------------------------------- ---------------------------xxSCD-L---------------- -------- >ENSPTRP00000035752 -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ----------x-----------xxxx------------------------ ----------------------xxxxx----------------------- --S-------------CLDLWREKNDRLVRQAK-Vx-QN----------- -------------------------------------------------- ------------xGLT---------------------------------- ----LRRQ----------------------------------------QL AQD---------------------------------------------AL EGLRGLLHSL---------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ---------------------Q---------------------------- ------G------------------------------------------- ---LPAAVPVLP-------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- --------------------------------------------LELTVT CNFIILRAS--LAQGFTEDQAQDIQRSLER-------------------- --------------VLETQE-QRG---PRxEQGLREL------------- --WDSV-------------------------------------------- -------------------------------------------------L RASCLLPELLSALHRLVG-------------------------------- -------------------------------------------------- -------------------------------------LQA---------- -----------------------------------------------ALW LSADRLGDLALL-------------------------------------- -------------------------------------LETLNG------- ---------------SQ--------S---GAS------------------ --KDLLL-----LLKTWSPPAEE--------------------------- -------------------------------------------------- -------------LDAPLTLQDAQGLKDVLL------------------- ------------------------T--------------------AFAYR QGL--------QELITGNP----------------DKALSSLHEVASGLC PRPV------------------------------LVQVYTALGSCHRKMG -------------------------------------------------- ----------------NPQRAL-----LYLVAALKEGSAWGPPLLE---- -------------------------------------------------- ---------------------------ASRLYQQLGDT----------TA ELESLELLVEALNVP----CS---SKA---------------------PQ FL----------------------------------IEVEL--------- -------------------------------------------------- -----------------LLPPPDLASPLHCGT------------------ -------------------------------------------------- -QSQTKHIL-----------------------------------ASRCLQ T------------------------------------------------- -------------------------------------------------- -----GRAGD----------AAEHY------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ----------------------------------------LDL------- -------------------------------------------------- -------------------------------------------------- ---------------LALLL-DSS-------------------------- -------------------------------------------------- -------------------------xPR---------------------- -------------------------------------------------- -----------------------------------F------S------- -----PPPSPP-GPCMPEVFLEAAVALIQAGRAQDA-------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ----------------------------------------LTLCE----- -------------------------------------------------- -------------------------------------------------- -------ELLSRTSSL-----LPKMSRLW--------------------- ------EDARx--------------------------------------- -------------------------------------------------- -------------------------------------GT----------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- K------------------------------------------------- -----------------------------------------ELPY----- ---------CPLWVSA---------------------------------- -------------------------------------------------- -------------------------------------------------- ----THLLQGQAWVQL--GAQKVAISEFSRCLELLFQA------------ ----------------------------xxx-EK---------------E Q----------------------------------------------xx- -------xF----------xxxxxxx------------------------ ------------xxA------------------A---------------- -----------------------LQQL----------------------- -------------------------------------------------- ----RAAALISRGLEWVAS------------------------------- ---------------------------GQDTKALQDFLLGV--------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- --QMCP-------------------------------------------- --------------------GNRDTYFH---------------------- -----------------------------LLQTLKRL------------- -------------------------------------------------- --DRRDEATAL---------------------W----------------- -------WRLEAQT-----KG-S----xxDAL----------W------- ------S-----------------------------------------LP LYLESY-------------------------------------------- -------------------------------------------LSWIRPS DRDAFLEE----------------------------------------FR TSL----------------------------------------------- ---------------------------xxSCD-L---------------- -------- >ENSPPAP00000030649 -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ----------x-----------xxxx------------------------ ----------------------xxxxx----------------------- --S-------------CLDLWREKNDRLVRQAK-Vx-QN----------- -------------------------------------------------- ------------xGLT---------------------------------- ----LRRQ----------------------------------------QL AQD---------------------------------------------AL EGLRGLLHSL---------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ---------------------Q---------------------------- ------G------------------------------------------- ---LPAAVPVLP-------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- --------------------------------------------LELTVT CNFIILRAS--LAQGFTEDQAQDIQRSLER-------------------- --------------VLETQE-QRG---PRxEQGLREL------------- --WDSV-------------------------------------------- -------------------------------------------------L RASCLLPELLSALHRLVG-------------------------------- -------------------------------------------------- -------------------------------------LQA---------- -----------------------------------------------ALW LSADRLGDLALL-------------------------------------- -------------------------------------LETLNG------- ---------------SQ--------S---GAS------------------ --KDLLL-----LLKTWSPPAEE--------------------------- -------------------------------------------------- -------------LDAPLTLQDAQGLKDVLL------------------- ------------------------T--------------------AFAYR QGL--------QELITGNP----------------DKALSSLHEVASGLC PRPV------------------------------LVQVYTALGSCHRKMG -------------------------------------------------- ----------------NPQRAL-----LYLVAALKEGSAWGPPLLE---- -------------------------------------------------- ---------------------------ASRLYQQLGDT----------TA ELESLELLVEALNVP----CS---SKA---------------------PQ FL----------------------------------IEVEL--------- -------------------------------------------------- -----------------LLPPPDLASPLHCGT------------------ -------------------------------------------------- -QSQTKHIL-----------------------------------ASRCLQ T------------------------------------------------- -------------------------------------------------- -----GRAGD----------AAEHY------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ----------------------------------------LDL------- -------------------------------------------------- -------------------------------------------------- ---------------LALLL-DSS-------------------------- -------------------------------------------------- -------------------------xPR---------------------- -------------------------------------------------- -----------------------------------F------S------- -----PPPSPP-GPCMPEVFLEAAVALIQAGRAQDA-------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ----------------------------------------LTLCE----- -------------------------------------------------- -------------------------------------------------- -------ELLSRTSSL-----LPKMSRLW--------------------- ------EDARx--------------------------------------- -------------------------------------------------- -------------------------------------GT----------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- K------------------------------------------------- -----------------------------------------ELPY----- ---------CPLWVSA---------------------------------- -------------------------------------------------- -------------------------------------------------- ----THLLQGQAWVQL--GAQKVAISEFSRCLELLFQA------------ ----------------------------xxx-EK---------------E Q----------------------------------------------xx- -------xF----------xxxxxxx------------------------ ------------xxA------------------A---------------- -----------------------LQQL----------------------- -------------------------------------------------- ----RAAALISRGLEWVAS------------------------------- ---------------------------GQDTKALQDFLLSV--------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- --QMCP-------------------------------------------- --------------------GNRDTYFH---------------------- -----------------------------LLQTLKRL------------- -------------------------------------------------- --DRRDEATAL---------------------W----------------- -------WRLEAQT-----KG-S----xxDAL----------W------- ------S-----------------------------------------LP LYLESY-------------------------------------------- -------------------------------------------LSWIRPS DRDAFLEE----------------------------------------FR TSL----------------------------------------------- ---------------------------xxSCD-L---------------- -------- >ENSGGOP00000003149 -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ----------x-----------xxxx------------------------ ----------------------xxxxx----------------------- --S-------------CLDLWREKNDRLVRQAK-Vx-QN----------- -------------------------------------------------- ------------xGLT---------------------------------- ----LRRQ----------------------------------------QL AQD---------------------------------------------AL EGLRGLLHSL---------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ---------------------Q---------------------------- ------G------------------------------------------- ---LPAAVPVLP-------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- --------------------------------------------LELTVT CNFIILRAS--LAQGFTEDQAQDIQRSLER-------------------- --------------VLETQE-QRG---PRxEQGLREL------------- --WDSV-------------------------------------------- -------------------------------------------------L RASCLLPELLSALHRLVG-------------------------------- -------------------------------------------------- -------------------------------------LQA---------- -----------------------------------------------ALW LSADRLGDLALL-------------------------------------- -------------------------------------LETLNG------- ---------------SQ--------S---GAS------------------ --KDLLL-----LLKTWSPPAEE--------------------------- -------------------------------------------------- -------------LDAPLTLQDAQGLKDVLL------------------- ------------------------T--------------------AFAYR QGL--------QELITGNP----------------DKALSSLHEVASGLC PRPV------------------------------LVQVYTALGSCHRKMG -------------------------------------------------- ----------------NPQRAL-----LYLVAALKEGSAWGPPLLE---- -------------------------------------------------- ---------------------------ASRLYQQLGDT----------TA ELESLELLVEALNVP----CS---SKA---------------------PQ FL----------------------------------IEVEL--------- -------------------------------------------------- -----------------LLPPPDLASPLHCGT------------------ -------------------------------------------------- -QSQTKHIL-----------------------------------ASRCLQ T------------------------------------------------- -------------------------------------------------- -----GRAGD----------AAEHY------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ----------------------------------------LDL------- -------------------------------------------------- -------------------------------------------------- ---------------LALLL-DSS-------------------------- -------------------------------------------------- -------------------------xPR---------------------- -------------------------------------------------- -----------------------------------F------S------- -----PPPSPP-GPCMPEVFLEAAVALIQAGRAQDA-------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ----------------------------------------LTLCE----- -------------------------------------------------- -------------------------------------------------- -------ELLSRTSSL-----LPKMSRLW--------------------- ------EDARx--------------------------------------- -------------------------------------------------- -------------------------------------GT----------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- K------------------------------------------------- -----------------------------------------ELPY----- ---------CPLWVSA---------------------------------- -------------------------------------------------- -------------------------------------------------- ----THLLQGQAWVQL--GAQKVAISEFSRCLELLFRA------------ ----------------------------xxx-EK---------------E Q----------------------------------------------xx- -------xF----------xxxxxxx------------------------ ------------xxA------------------A---------------- -----------------------LQQL----------------------- -------------------------------------------------- ----RAAALISRGLEWVAS------------------------------- ---------------------------GQDTRALQDFLLSV--------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- --QMCP-------------------------------------------- --------------------GNRDTYFH---------------------- -----------------------------LLQTLKRL------------- -------------------------------------------------- --DRRDEATAL---------------------W----------------- -------WRLEAQT-----KG-S----xxDAL----------W------- ------S-----------------------------------------LP LYLESY-------------------------------------------- -------------------------------------------LSWIRPS DRDAFLEE----------------------------------------FR TSL----------------------------------------------- ---------------------------xxSCD-L---------------- -------- >ENSP00000367910 -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ----------x-----------xxxx------------------------ ----------------------xxxxx----------------------- --S-------------CLDLWREKNDRLVRQAK-Vx-QN----------- -------------------------------------------------- ------------xGLT---------------------------------- ----LRRQ----------------------------------------QL AQD---------------------------------------------AL EGLRGLLHSL---------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ---------------------Q---------------------------- ------G------------------------------------------- ---LPAAVPVLP-------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- --------------------------------------------LELTVT CNFIILRAS--LAQGFTEDQAQDIQRSLER-------------------- --------------VLETQE-QQG---PRxEQGLREL------------- --WDSV-------------------------------------------- -------------------------------------------------L RASCLLPELLSALHRLVG-------------------------------- -------------------------------------------------- -------------------------------------LQA---------- -----------------------------------------------ALW LSADRLGDLALL-------------------------------------- -------------------------------------LETLNG------- ---------------SQ--------S---GAS------------------ --KDLLL-----LLKTWSPPAEE--------------------------- -------------------------------------------------- -------------LDAPLTLQDAQGLKDVLL------------------- ------------------------T--------------------AFAYR QGL--------QELITGNP----------------DKALSSLHEAASGLC PRPV------------------------------LVQVYTALGSCHRKMG -------------------------------------------------- ----------------NPQRAL-----LYLVAALKEGSAWGPPLLE---- -------------------------------------------------- ---------------------------ASRLYQQLGDT----------TA ELESLELLVEALNVP----CS---SKA---------------------PQ FL----------------------------------IEVEL--------- -------------------------------------------------- -----------------LLPPPDLASPLHCGT------------------ -------------------------------------------------- -QSQTKHIL-----------------------------------ASRCLQ T------------------------------------------------- -------------------------------------------------- -----GRAGD----------AAEHY------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ----------------------------------------LDL------- -------------------------------------------------- -------------------------------------------------- ---------------LALLL-DSS-------------------------- -------------------------------------------------- -------------------------xPR---------------------- -------------------------------------------------- -----------------------------------F------S------- -----PPPSPP-GPCMPEVFLEAAVALIQAGRAQDA-------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ----------------------------------------LTLCE----- -------------------------------------------------- -------------------------------------------------- -------ELLSRTSSL-----LPKMSRLW--------------------- ------EDARx--------------------------------------- -------------------------------------------------- -------------------------------------GT----------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- K------------------------------------------------- -----------------------------------------ELPY----- ---------CPLWVSA---------------------------------- -------------------------------------------------- -------------------------------------------------- ----THLLQGQAWVQL--GAQKVAISEFSRCLELLFRA------------ ----------------------------xxx-EK---------------E Q----------------------------------------------xx- -------xF----------xxxxxxx------------------------ ------------xxA------------------A---------------- -----------------------LQQL----------------------- -------------------------------------------------- ----RAAALISRGLEWVAS------------------------------- ---------------------------GQDTKALQDFLLSV--------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- --QMCP-------------------------------------------- --------------------GNRDTYFH---------------------- -----------------------------LLQTLKRL------------- -------------------------------------------------- --DRRDEATAL---------------------W----------------- -------WRLEAQT-----KG-S----xxDAL----------W------- ------S-----------------------------------------LP LYLESY-------------------------------------------- -------------------------------------------LSWIRPS DRDAFLEE----------------------------------------FR TSL----------------------------------------------- ---------------------------xxSCD-L---------------- -------- >ENSPPYP00000021407 -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ----------x-----------xxxx------------------------ ----------------------xxxxx----------------------- --S-------------CLDLWREKNDRLVRQAE-Vx-QN----------- -------------------------------------------------- ------------xGLT---------------------------------- ----LRRQ----------------------------------------HL AQD---------------------------------------------AL EGLRGLLHSL---------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ---------------------Q---------------------------- ------G------------------------------------------- ---LPAAIPVLP-------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- --------------------------------------------LELTVT CNFIILRAS--LAQGFTEDQAQDIQRSLER-------------------- --------------VLETQE-QWG---PRxEQGLREL------------- --WDSV-------------------------------------------- -------------------------------------------------L RASCLLPELLSALHRLAG-------------------------------- -------------------------------------------------- -------------------------------------LQA---------- -----------------------------------------------ALW LSADRLGDLALL-------------------------------------- -------------------------------------LETLNG------- ---------------SQ--------S---GAS------------------ --KDLLL-----LLKTWSPPAEE--------------------------- -------------------------------------------------- -------------LDAPLTLQDAQGLKDVLL------------------- ------------------------T--------------------AFAYR QGL--------QELITGNP----------------DKALSSLHEAASGLC PRPV------------------------------LVQVYTALGSCHRKMG -------------------------------------------------- ----------------NPQRAL-----LYLVAALKEGSAWGPPLLE---- -------------------------------------------------- ---------------------------ASRLYQQLGDT----------TA ELESLELLVEALNVP----CS---SKA---------------------PQ FL----------------------------------IEVEL--------- -------------------------------------------------- -----------------LLPPPDLASPLHCGT------------------ -------------------------------------------------- -QSQTKHIL-----------------------------------ASRCLQ T------------------------------------------------- -------------------------------------------------- -----GRAGD----------AAEHY------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ----------------------------------------LDL------- -------------------------------------------------- -------------------------------------------------- ---------------LALLL-DSS-------------------------- -------------------------------------------------- -------------------------xPR---------------------- -------------------------------------------------- -----------------------------------F------S------- -----PPPSPP-GPCMPEVFLEAAVALIQAGRAQDA-------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ----------------------------------------LTLCE----- -------------------------------------------------- -------------------------------------------------- -------ELLSRTSSL-----LPKMSRLW--------------------- ------EDARx--------------------------------------- -------------------------------------------------- -------------------------------------GT----------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- K------------------------------------------------- -----------------------------------------ELPY----- ---------CPLWVSA---------------------------------- -------------------------------------------------- -------------------------------------------------- ----THLLQGQAWVQL--GAQKVAISEFSRCLELLFRA------------ ----------------------------xxx-EK---------------E K----------------------------------------------xx- -------xF----------xxxxxxx------------------------ ------------xxV------------------A---------------- -----------------------LQQL----------------------- -------------------------------------------------- ----RAAALISRGLEWVAS------------------------------- ---------------------------GQDTKALQDFLLSV--------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- --QMCP-------------------------------------------- --------------------GNRDTYFH---------------------- -----------------------------LLQTLKRL------------- -------------------------------------------------- --DRRDEASAL---------------------W----------------- -------WRLEAQT-----KG-P----xxDAM----------W------- ------S-----------------------------------------LP LYLESY-------------------------------------------- -------------------------------------------LSWIRPS DRDALLEE----------------------------------------FR TSL----------------------------------------------- ---------------------------xxSCD-L---------------- -------- >ENSPCOP00000021133 -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ----------x-----------xxxx------------------------ ----------------------xx-xx----------------------- --S-------------CLDLWREKNDQLVRQAK-Vx-QD----------- -------------------------------------------------- ------------xDLS---------------------------------- ----LRRQ----------------------------------------QL AQD---------------------------------------------AL EGLRELLHSL---------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ---------------------Q---------------------------- ------G------------------------------------------- ---LPAAVPVLP-------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- --------------------------------------------LELTVT CNFIILKTS--VTQGFTEDQALDIQWGLER-------------------- --------------VLETQE-QLG---PRxERGLRDL------------- --WDSV-------------------------------------------- -------------------------------------------------L YASSLLPELLPALHRLAG-------------------------------- -------------------------------------------------- -------------------------------------LQA---------- -----------------------------------------------ALW LSTDHLRDLALL-------------------------------------- -------------------------------------LQTLNG------- ---------------SQ--------S---GSS------------------ --EDLLL-----HLKTWSPPAEE--------------------------- -------------------------------------------------- -------------SDAPLTLQDARGLRDVLL------------------- ------------------------T--------------------AFTYR QGL--------QELIIGNL----------------PKALSSLHEAASGLC PRPV------------------------------LVQVYTALGTCLRKMG -------------------------------------------------- ----------------NPQRAL-----VYLIEALKGGSTLGPPLLE---- -------------------------------------------------- ---------------------------ASRLYQQLGDT----------AA ELESLELLVEALSVT----HS---SEA---------------------PQ LL----------------------------------IEVEL--------- -------------------------------------------------- -----------------LLPRPDPASPLHCGT------------------ -------------------------------------------------- -QSQAKHLL-----------------------------------ASRCLQ T------------------------------------------------- -------------------------------------------------- -----GRAED----------AAEHY------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ----------------------------------------LDL------- -------------------------------------------------- -------------------------------------------------- ---------------LALLL-DGS-------------------------- -------------------------------------------------- -------------------------xPR---------------------- -------------------------------------------------- -----------------------------------F------S------- -----PPHSLP-GPCMPEVFLEAAAALIQAGRAQDA-------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ----------------------------------------LTVCE----- -------------------------------------------------- -------------------------------------------------- -------ELLSRASSL-----LPKMSQLW--------------------- ------KDDRx--------------------------------------- -------------------------------------------------- -------------------------------------GT----------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- K------------------------------------------------- -----------------------------------------DLPH----- ---------CPLWVSA---------------------------------- -------------------------------------------------- -------------------------------------------------- ----THLLQGQAWVQL--GAQKEAVSEFSWCLELLFRA------------ ----------------------------xxx-DK---------------E Q----------------------------------------------xx- -------xS----------xxxxxxx------------------------ ------------xxV------------------A---------------- -----------------------LQQL----------------------- -------------------------------------------------- ----RAAALISRGLEWVAR------------------------------- ---------------------------GQDTKALQDFLLSV--------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- --QMCP-------------------------------------------- --------------------GNQDASIH---------------------- -----------------------------LLQTLRRL------------- -------------------------------------------------- --DRRDEATAL---------------------W----------------- -------WRLEAQT-----KL-P----xxDTT----------W------- ------S-----------------------------------------LP LYLETC-------------------------------------------- -------------------------------------------LSWIRPS DHETLLEE----------------------------------------FR ISV----------------------------------------------- ---------------------------xxPRD-L---------------- -------- >ENSPSMP00000007231 -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ----------x-----------xxxx------------------------ ----------------------xx-xx----------------------- --S-------------CLDLWREKNDQLVRQVK-Vx-QD----------- -------------------------------------------------- ------------xGLS---------------------------------- ----LRRQ----------------------------------------QL AQD---------------------------------------------AL EGLRELLCSL---------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ---------------------Q---------------------------- ------G------------------------------------------- ---LPAAVAVLP-------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- --------------------------------------------LELTVT CNFIILKTS--VAQGFTEDQTQDIQRGLER-------------------- --------------VLETQE-QLG---PRxERGLMEL------------- --WDSV-------------------------------------------- -------------------------------------------------L HASSLLLDLLPALHRLAG-------------------------------- -------------------------------------------------- -------------------------------------LQA---------- -----------------------------------------------ALW LSTDHLRDLALL-------------------------------------- -------------------------------------LQTLNG------- ---------------SQ--------S---GSS------------------ --EDLLL-----HLKTWSPPAEE--------------------------- -------------------------------------------------- -------------SDAPLTLQDARGLRDVLL------------------- ------------------------T--------------------AFTYR QGL--------QELIIGNL----------------PKALSSLHEAASGLC PRPV------------------------------LVQVYTALGTCLRKMG -------------------------------------------------- ----------------NPQRAL-----VYLVEALKGGSALGPPLLE---- -------------------------------------------------- ---------------------------ASRLYQQLGDT----------AA ELESLELLVEALSVT----HS---SEA---------------------PQ LL----------------------------------IEVEL--------- -------------------------------------------------- -----------------LLPRLDPALPLHCGT------------------ -------------------------------------------------- -QSQAKHLL-----------------------------------ASRCLQ T------------------------------------------------- -------------------------------------------------- -----GRAED----------AAEHY------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ----------------------------------------LDL------- -------------------------------------------------- -------------------------------------------------- ---------------LALLL-DGS-------------------------- -------------------------------------------------- -------------------------xPR---------------------- -------------------------------------------------- -----------------------------------F------A------- -----PPPSPP-GPCMPEVFLEAAAALIQAGRAQDA-------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ----------------------------------------LTVCE----- -------------------------------------------------- -------------------------------------------------- -------ELLSRTSFL-----LPKMSQLW--------------------- ------KGARx--------------------------------------- -------------------------------------------------- -------------------------------------GT----------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- K------------------------------------------------- -----------------------------------------GLPH----- ---------CPLWVSA---------------------------------- -------------------------------------------------- -------------------------------------------------- ----THLLQGQAWVQL--GAQKEAVSEFSWCLELLFRS------------ ----------------------------xxx-DK---------------E Q----------------------------------------------xx- -------xS----------xxxxxxx------------------------ ------------xxV------------------A---------------- -----------------------LQQL----------------------- -------------------------------------------------- ----QAAALISRGLEWVAC------------------------------- ---------------------------GQDTKALQDFLLSV--------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- --QMCP-------------------------------------------- --------------------GNRDASIH---------------------- -----------------------------LLQTLRRL------------- -------------------------------------------------- --DRRDEATAL---------------------W----------------- -------WRLEAQT-----KL-P----xxDTT----------W------- ------S-----------------------------------------LP LYLETC-------------------------------------------- -------------------------------------------LSWIRPS DHETLLEE----------------------------------------FR TSV----------------------------------------------- ---------------------------xxPRG-L---------------- -------- >ENSMICP00000005010 -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ----------x-----------xxxx------------------------ ----------------------xx-xx----------------------- --N-------------CLDLWREKNDQLVRQAK-Vx-QD----------- -------------------------------------------------- ------------xSLS---------------------------------- ----LRRQ----------------------------------------QL AQD---------------------------------------------AL EGLRELLHSL---------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ---------------------Q---------------------------- ------G------------------------------------------- ---LPAAVPALP-------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- --------------------------------------------LELTVT CNFIILKTS--VAQGFTEDQAQAIQRGLER-------------------- --------------VLETQE-QLG---PRxERGLGEL------------- --WDSV-------------------------------------------- -------------------------------------------------L HVSSLLPELLPALHCLAG-------------------------------- -------------------------------------------------- -------------------------------------LQA---------- -----------------------------------------------ALW LSTDHLRYLALL-------------------------------------- -------------------------------------LQSLNG------- ---------------SQ--------S---GSS------------------ --EDLLL-----HLKTWSPPAEE--------------------------- -------------------------------------------------- -------------SDAPLILQDAQGLRDVLL------------------- ------------------------TxxxxLIPSLxxxxxxxxxxx----- ------------ELIIGNL----------------PKALSSLHEVASGLC PRPV------------------------------LVQVYTALGTCLRKMG -------------------------------------------------- ----------------NPQRAL-----VYLVEALKGGSALGPPLLE---- -------------------------------------------------- ---------------------------ASRLYQQLGDT----------AA ELESLELLVEALSVT----QS---SEA---------------------PQ LL----------------------------------IEVEL--------- -------------------------------------------------- -----------------LLPQSDPASPLHCGT------------------ -------------------------------------------------- -QSQAKHLL-----------------------------------ASRCLQ T------------------------------------------------- -------------------------------------------------- -----GRAED----------AAEHY------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ----------------------------------------LDL------- -------------------------------------------------- -------------------------------------------------- ---------------LALLL-DGS-------------------------- -------------------------------------------------- -------------------------xPR---------------------- -------------------------------------------------- -----------------------------------F------S------- -----PPPSPP-GPCMPEVFLEAAAALIQAGRAQDA-------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ----------------------------------------LTVCE----- -------------------------------------------------- -------------------------------------------------- -------ELLSRTSSL-----LPKMSQLW--------------------- ------KDARx--------------------------------------- -------------------------------------------------- -------------------------------------GT----------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- K------------------------------------------------- -----------------------------------------DLPH----- ---------CPLWVSA---------------------------------- -------------------------------------------------- -------------------------------------------------- ----THLLQGQAWVQL--GSQKEAVSEFSWCLELLFRA------------ ----------------------------xxx-DK---------------E Q----------------------------------------------xx- -------xS----------xxxxxxx------------------------ ------------xxV------------------T---------------- -----------------------LQQL----------------------- -------------------------------------------------- ----RAAALISRGLEWVAR------------------------------- ---------------------------GQDTKALQDFLLSV--------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- --QMCP-------------------------------------------- --------------------GNRDASIH---------------------- -----------------------------LLQTLRRL------------- -------------------------------------------------- --DRRDEATAF---------------------W----------------- -------WRLEAQT-----KL-P----xxDAT----------W------- ------S-----------------------------------------LP LYLETC-------------------------------------------- -------------------------------------------LSWIRPS DHETCLEE----------------------------------------FR TSV----------------------------------------------- ---------------------------xxPRD-L---------------- -------- >ENSTSYP00000013694 -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ----------x-----------xxxx------------------------ ----------------------xx-xx----------------------- --G-------------CLDLWREQNDRFVRQAK-Mx-QD----------- -------------------------------------------------- ------------xGLS---------------------------------- ----LRRQ----------------------------------------QL AQD---------------------------------------------AL EGLKGLICTL---------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ---------------------Q---------------------------- ------G------------------------------------------- ---IPAAVPVLS-------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- --------------------------------------------LELTVI CNFIILKAS--LAQGFTEDQAQDIQRGLER-------------------- --------------VLETQE-QLG---PTxQWGLREL------------- --WDSV-------------------------------------------- -------------------------------------------------L RASSCLPELLPAVHHLAS-------------------------------- -------------------------------------------------- -------------------------------------LQA---------- -----------------------------------------------ALW LSTDHLGDLALL-------------------------------------- -------------------------------------LQALNG------- ---------------SQ--------T---GAS------------------ --EDLLL-----LLKTWNPPSEE--------------------------- -------------------------------------------------- -------------LDAPLILQDARGLKDVLV------------------- ------------------------T--------------------AFAYR QGL--------QELITGNL----------------PKALRSLHEATSTLC PRSV------------------------------LVQVYTALGTCLRKMG -------------------------------------------------- ----------------NPQRAL-----LYLLAALKVGSACGPPLLE---- -------------------------------------------------- ---------------------------ASRLYQQLGDT----------AA ELESLELLVEALGVP----LN---SKA---------------------PQ LL----------------------------------IEVEL--------- -------------------------------------------------- -----------------LLPPPDPDSPLHCGT------------------ -------------------------------------------------- -QGQAKHLL-----------------------------------ASRCLQ T------------------------------------------------- -------------------------------------------------- -----GRAED----------AAEHY------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ----------------------------------------LDL------- -------------------------------------------------- -------------------------------------------------- ---------------LALLL-DDS-------------------------- -------------------------------------------------- -------------------------xPR---------------------- -------------------------------------------------- -----------------------------------F------S------- -----PPPCPP-GPCMPELFLEAAAALIQAGRAQDA-------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ----------------------------------------LTICE----- -------------------------------------------------- -------------------------------------------------- -------ELLGRTSSL-----LPKMSQLW--------------------- ------EDARx--------------------------------------- -------------------------------------------------- -------------------------------------GT----------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- K------------------------------------------------- -----------------------------------------ELPQ----- ---------CPLWVSA---------------------------------- -------------------------------------------------- -------------------------------------------------- ----THLLQGQAWVQL--RAQKEAVSEFSRCLELLFRV------------ ----------------------------xxx-DK---------------E Q----------------------------------------------xx- -------xS----------xxxxxxx------------------------ ------------xxV------------------V---------------- -----------------------RQQL----------------------- -------------------------------------------------- ----RSAALISRGLEWVAS------------------------------- ---------------------------GQDTKALQDFLLSV--------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- --QVCP-------------------------------------------- --------------------GNQDASFH---------------------- -----------------------------LLQTLRRL------------- -------------------------------------------------- --DRKDEATAL---------------------W----------------- -------WKMEAQT-----KL-P----xxAAT----------W------- ------S-----------------------------------------LP LYLETY-------------------------------------------- -------------------------------------------LNWIHPS ERETLLEE----------------------------------------FQ TSL----------------------------------------------- ---------------------------xxPCD-L---------------- -------- >ENSCCNP00000025332 -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ----------x-----------xxxxx----------------------- ---------xx---------xxxx-xxxxx-------------------- xTS-------------CLDLWREKNDRLVRQAK-VA-QN----------- -------------------------------------------------- ------------xRLS---------------------------------- ----LRRQ----------------------------------------QL AQD---------------------------------------------TL EGLRELLHSL---------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ---------------------Q---------------------------- ------G------------------------------------------- ---LPAAISVLP-------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- --------------------------------------------LELTVI CNFITLRVS--LARGFTDDLTQDIQQGLER-------------------- --------------VLETQE-QLG---PRxGQGLGEL------------- --WDAI-------------------------------------------- -------------------------------------------------L RASSLLPELLPALHHLVG-------------------------------- -------------------------------------------------- -------------------------------------LQA---------- -----------------------------------------------ALW LSTDRIGDLALL-------------------------------------- -------------------------------------LQTLNG------- ---------------SQ--------S---GAS------------------ --EDLLL-----LLKTWSPPVKE--------------------------- -------------------------------------------------- -------------SDAPLTLQDAQGLRDVLL------------------- ------------------------T--------------------AFAFR QGL--------QELITGSL----------------PRALSILHEAASGLC PRPV------------------------------LVQVYTALGTCLRKMG -------------------------------------------------- ----------------NPQRAL-----LYLIAALKVGTACGLPLLE---- -------------------------------------------------- ---------------------------ASRLYQQLGDA----------SA ELESLELLVEALSAT----HS---FEA---------------------PQ LL----------------------------------IEVEL--------- -------------------------------------------------- -----------------LLPQPDQASPLHCGT------------------ -------------------------------------------------- -QSQAKHLL-----------------------------------ASRCLQ L------------------------------------------------- -------------------------------------------------- -----GRAED----------AAEHY------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ----------------------------------------LDL------- -------------------------------------------------- -------------------------------------------------- ---------------LALLL-DGS-------------------------- -------------------------------------------------- -------------------------xPR---------------------- -------------------------------------------------- -----------------------------------F------S------- -----PPPAPP-GPCVPEVFLEAAAAMIQAGRAQDA-------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ----------------------------------------LTICE----- -------------------------------------------------- -------------------------------------------------- -------ELLSRTSAL-----LPKMSQLW--------------------- ------EDARx--------------------------------------- -------------------------------------------------- -------------------------------------GA----------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- K------------------------------------------------- -----------------------------------------ELPH----- ---------CPLWVSA---------------------------------- -------------------------------------------------- -------------------------------------------------- ----THLLQGQAWVQL--KAQKEAVSEFSWCLELLFRA------------ ----------------------------xxx-DK---------------E Q----------------------------------------------xx- -------xP----------xxxxxxx------------------------ ------------xxV------------------V---------------- -----------------------LQQL----------------------- -------------------------------------------------- ----RAAALISRGLEWVAS------------------------------- ---------------------------GQDTKALKDFLLSV--------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- --QMSP-------------------------------------------- --------------------GNKDASFH---------------------- -----------------------------LLQTLKKL------------- -------------------------------------------------- --DRKDEALVL---------------------W----------------- -------QRLKVQT-----QM-P----xxEAA----------W------- ------S-----------------------------------------LP LYLETY-------------------------------------------- -------------------------------------------LSWIHPP DCETLLEE----------------------------------------FR TAL----------------------------------------------- ---------------------------xxPCD-L---------------- -------- >ENSDNOP00000011296 -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ----------M-----------SxxA------------------------ ---------xx--------------xxxxx-------------------- xAS-------------CLDLWREKNDQLVRQSK-xx-xT----------- -------------------------------------------------- ------------xGVS---------------------------------- ----LRRQ----------------------------------------QL AQD---------------------------------------------AL EGLRGLLRSL---------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ---------------------Q---------------------------- ------G------------------------------------------- ---LPAAVSALP-------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- --------------------------------------------LELTVI CNFITLRAS--LAQGFTEDQAQEIQRGLER-------------------- --------------VLEAQA-QLG---PRxEYGLREL------------- --WDFV-------------------------------------------- -------------------------------------------------L HSSSRMPELLPALHHLAG-------------------------------- -------------------------------------------------- -------------------------------------LQA---------- -----------------------------------------------ALW LSTDHLGDLGLL-------------------------------------- -------------------------------------LQTLNG------- ---------------SQ--------S---GAS------------------ --EDLLV-----LLKTWSPPAEE--------------------------- -------------------------------------------------- -------------SEAPLSLQDTRGLRDVLL------------------- ------------------------T--------------------ASAFR QGL--------QELITGNL----------------PRALSNLHEAASGLC PRPV------------------------------LVQVYTALATCLRKMG -------------------------------------------------- ----------------NPQRAL-----LYLVAALKGGSAWGPPLLE---- -------------------------------------------------- ---------------------------ACRLYQQLGNI----------AA ELESLELLVEALSIT----QS---SEI---------------------PQ LL----------------------------------IEVKL--------- -------------------------------------------------- -----------------LLPQPDPASPLHCGT------------------ -------------------------------------------------- -QSQAKHLL-----------------------------------ASRCLQ T------------------------------------------------- -------------------------------------------------- -----GRAED----------AAEHY------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ----------------------------------------LDL------- -------------------------------------------------- -------------------------------------------------- ---------------LALLL-DGP-------------------------- -------------------------------------------------- -------------------------xPR---------------------- -------------------------------------------------- -----------------------------------F------S------- -----PPHLPP-GPSMPEVFLEAAAALIEAGRAQDA-------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ----------------------------------------LTVCE----- -------------------------------------------------- -------------------------------------------------- -------ELLHRTSSL-----LPKMHWLW--------------------- ------EDARx--------------------------------------- -------------------------------------------------- -------------------------------------EA----------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- K------------------------------------------------- -----------------------------------------EPPH----- ---------CPLWVSA---------------------------------- -------------------------------------------------- -------------------------------------------------- ----TYLLQGQAWVQL--GSQKEAISEFSRCLELLFRA------------ ----------------------------xxx-DK---------------E E----------------------------------------------xx- -------xS----------xxxxxxx------------------------ ------------xxV------------------T---------------- -----------------------LQQL----------------------- -------------------------------------------------- ----QAAALISRGLQWVAS------------------------------- ---------------------------GQDTKALQDFLLSV--------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- --QMCP-------------------------------------------- --------------------RNQDASFH---------------------- -----------------------------LLQTLRRL------------- -------------------------------------------------- --DRRDEATAL---------------------W----------------- -------WRLEAQS-----KL-P----xxDAV----------W------- ------S-----------------------------------------LP LYLEAC-------------------------------------------- -------------------------------------------LSWTRPP DCETLLEE----------------------------------------FR TSL----------------------------------------------- ---------------------------xxPCE-Q---------------- -------- >ENSLAFP00000017720 -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ----------T-----------xxxT------------------------ ----------------------xx-xxxxx-------------------- xAS-------------CLDLWREKNDLLVRQAK-Vx-QD----------- -------------------------------------------------- ------------xGLL---------------------------------- ----LRQQ----------------------------------------HL AQD---------------------------------------------AL QGFRELLHSL---------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ---------------------R---------------------------- ------G------------------------------------------- ---LPAAISALP-------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- --------------------------------------------LELTVI CNFITLKVS--HTQGFTEDQAQDIQQGLER-------------------- --------------VLEAQE-QLG---PRxECGLREL------------- --WDSV-------------------------------------------- -------------------------------------------------L HISSLLPELLPALHHLAG-------------------------------- -------------------------------------------------- -------------------------------------LQA---------- -----------------------------------------------ALW LSTDRLGDLALL-------------------------------------- -------------------------------------LQSLNG------- ---------------SQ--------S---GAS------------------ --EDLLL-----LLKTWSPPVEE--------------------------- -------------------------------------------------- -------------SDAPLTLQDARGLRDVLL------------------- ------------------------T--------------------ASALC QGL--------QELITGTL----------------PRALSSLQEAASGLC SRPV------------------------------LVQVYTALGTCLRKMG -------------------------------------------------- ----------------NPQRAL-----LYLVAALKGGSVWGPPLLE---- -------------------------------------------------- ---------------------------ASRLYRQLGDT----------AA ELESLELLVDALSVT----QN---SET---------------------PQ LL----------------------------------IEVEL--------- -------------------------------------------------- -----------------LLPQPNPDSPLYCGT------------------ -------------------------------------------------- -QSQAKHLL-----------------------------------ASRCLQ T------------------------------------------------- -------------------------------------------------- -----GRAED----------AAEHY------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ----------------------------------------LDL------- -------------------------------------------------- -------------------------------------------------- ---------------LALLL-DGL-------------------------- -------------------------------------------------- -------------------------xPR---------------------- -------------------------------------------------- -----------------------------------F------S------- -----PLPCPP-GPCMPEVFLEAAAALIQANRAQDA-------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ----------------------------------------LTVCE----- -------------------------------------------------- -------------------------------------------------- -------ELLIRTSSL-----LPKMPWSW--------------------- ------EDARx--------------------------------------- -------------------------------------------------- -------------------------------------GA----------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- K------------------------------------------------- -----------------------------------------EPIN----- ---------CPLWVSA---------------------------------- -------------------------------------------------- -------------------------------------------------- ----TYLLQGQAWVKM--GDQKEAVSEFSRCLELLFRA------------ ----------------------------xxx-DR---------------E Q----------------------------------------------xx- -------xS----------xxxxxxx------------------------ ------------xxV------------------A---------------- -----------------------LQQL----------------------- -------------------------------------------------- ----RLAALISRGLVWVAS------------------------------- ---------------------------GQDTKALQDFLLSV--------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- --QICP-------------------------------------------- --------------------GNRDASFH---------------------- -----------------------------LLQTLRRL------------- -------------------------------------------------- --DRRNEATAF---------------------W----------------- -------WRLEAQT-----EL-P----xxDAT----------W------- ------S-----------------------------------------LP LYLETC-------------------------------------------- -------------------------------------------LSWIHPL DQETLLEE----------------------------------------FR TSL----------------------------------------------- ---------------------------xxTSD-L---------------- -------- >ENSSTOP00000013621 -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ---xxxxxx---xxxxCLDLWKEKNDRLVRQAK-Vx-QD----------- -------------------------------------------------- ------------xGVS---------------------------------- ----LRRH----------------------------------------KL VQD---------------------------------------------TL EGLRELLHIL---------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ---------------------H---------------------------- ------G------------------------------------------- ---LPAAVPVLP-------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- --------------------------------------------LELTVT CNFIILKVS--LAQGFTEDQAQDIQRGLER-------------------- --------------VLETQE-QLG---PRxEQGIRKL------------- --WESV-------------------------------------------- -------------------------------------------------L CASSLLPKLLCALHHLAG-------------------------------- -------------------------------------------------- -------------------------------------LQA---------- -----------------------------------------------ALW LSIDRLEDLALL-------------------------------------- -------------------------------------LQTLNG------- ---------------NQ--------N---GAS------------------ --KDLLL-----LLKTWNPPAEE--------------------------- -------------------------------------------------- -------------SDAPLTLQNAQGLRDILL------------------- ------------------------T--------------------AFAYR QGL--------QELISGSL----------------PRALSSLHEAASGLC PRPL------------------------------LVQVYTALGSCLRKMG -------------------------------------------------- ----------------NPQRAL-----LYLIAALKGGSPWGLPLLE---- -------------------------------------------------- ---------------------------ASRLYRQLGDT----------AA ELESLELLVEALSTT----HS---SEV---------------------PQ PL----------------------------------IEVEL--------- -------------------------------------------------- -----------------LLPRPDPASPLYCGT------------------ -------------------------------------------------- -QSQAKHLL-----------------------------------ASRCLQ M------------------------------------------------- -------------------------------------------------- -----GRAED----------AAEHY------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ----------------------------------------LDL------- -------------------------------------------------- -------------------------------------------------- ---------------LALLL-DGS-------------------------- -------------------------------------------------- -------------------------xPR---------------------- -------------------------------------------------- -----------------------------------F------C------- -----PPTSPP-GPCMPEVFLEAAAALIQAGRAQDA-------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ----------------------------------------LTVCE----- -------------------------------------------------- -------------------------------------------------- -------ELLTRTSSL-----LPKMLQPW--------------------- ------EDARx--------------------------------------- -------------------------------------------------- -------------------------------------GT----------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- K------------------------------------------------- -----------------------------------------ELPS----- ---------CPLWVSA---------------------------------- -------------------------------------------------- -------------------------------------------------- ----VYLLQGRAWVQL--RAPKEAISEFSRCLELLFRA------------ ----------------------------xxx-DK---------------E Q----------------------------------------------xx- -------xS----------xxxxxxx------------------------ ------------xxM------------------A---------------- -----------------------LKHL----------------------- -------------------------------------------------- ----RAAALISRGLEWAAN------------------------------- ---------------------------GQDTKALQDFLLSV--------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- --QVCP-------------------------------------------- --------------------GNRDASFY---------------------- -----------------------------LLQTLRRL------------- -------------------------------------------------- --DRKDEAAAF---------------------C----------------- -------WRLQAQT-----Qx----------------------------- ------S-----------------------------------------LP LYLEIY-------------------------------------------- -------------------------------------------LSWIHSP DCETFLEE----------------------------------------FQ TSL----------------------------------------------- ---------------------------xxPHD-L---------------- -------- >ENSUPAP00010023247 -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ----------M-----------AxxS------------------------ ----------------------xx-xxxxx-------------------- xAS-------------CLDLWKEKNDRLVRQAK-Vx-QD----------- -------------------------------------------------- ------------xGVS---------------------------------- ----LRRH----------------------------------------KL VQD---------------------------------------------TL EGLRELLHIL---------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ---------------------H---------------------------- ------G------------------------------------------- ---LPAAVPVLP-------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- --------------------------------------------LELTVT CNFIILKVS--LAQGFTEDEAQDIQRGLER-------------------- --------------VLETQE-QLG---PRxEQGIRKL------------- --WESV-------------------------------------------- -------------------------------------------------L CASSLLPKLLCALHHLVG-------------------------------- -------------------------------------------------- -------------------------------------LQA---------- -----------------------------------------------ALW LSIDRLEDLALL-------------------------------------- -------------------------------------LQTLNG------- ---------------NQ--------N---GAS------------------ --KDLLL-----LLKTWNPPAEE--------------------------- -------------------------------------------------- -------------SDAPLTLQNARGLRDILL------------------- ------------------------T--------------------AFAYR QGL--------QELISGSL----------------PRALSSLHEAASGLC PRPL------------------------------LVQVYTALGSCLRKMG -------------------------------------------------- ----------------NPQRAL-----LYLIAALKGGSPWGLPLLE---- -------------------------------------------------- ---------------------------ASRLYRQLGDT----------AA ELESLELLVEALSAT----HS---SEV---------------------PQ PL----------------------------------IEVEL--------- -------------------------------------------------- -----------------LLPRPDPASPLYCGT------------------ -------------------------------------------------- -QSQAKHLL-----------------------------------ASRCLQ M------------------------------------------------- -------------------------------------------------- -----GRAED----------AAEHY------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ----------------------------------------LDL------- -------------------------------------------------- -------------------------------------------------- ---------------LALLL-DGS-------------------------- -------------------------------------------------- -------------------------xPR---------------------- -------------------------------------------------- -----------------------------------F------C------- -----PPTSPP-GPCMPEVFLEAAAALIQAGRAQDA-------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ----------------------------------------LTVCE----- -------------------------------------------------- -------------------------------------------------- -------ELLTRTSSL-----LPKMLQPW--------------------- ------EDARx--------------------------------------- -------------------------------------------------- -------------------------------------GT----------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- K------------------------------------------------- -----------------------------------------ELPS----- ---------CPLWVSA---------------------------------- -------------------------------------------------- -------------------------------------------------- ----VYLLQGRAWVQL--RAPKEAISEFSRCLELLFRA------------ ----------------------------xxx-DK---------------E Q----------------------------------------------xx- -------xS----------xxxxxxx------------------------ ------------xxM------------------A---------------- -----------------------LKQL----------------------- -------------------------------------------------- ----RAAALISRGLEWAAN------------------------------- ---------------------------GQDTKALQDFLLSV--------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- --QMCP-------------------------------------------- --------------------GNRDASFH---------------------- -----------------------------LLQTLRRL------------- -------------------------------------------------- --DRKDEAAXF---------------------C----------------- -------WRLQAQT-----QL-P----xxEAT----------W------- ------S-----------------------------------------LP LYLEIY-------------------------------------------- -------------------------------------------LSWIHSP DCETFLEE----------------------------------------FQ TSL----------------------------------------------- ---------------------------xxPHD-L---------------- -------- >ENSSDAP00000005265 -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ----------M-----------AxxS------------------------ ----------------------xx-xxxxx-------------------- xAS-------------CLDLWKEKNDRLVRQAKQVx-QD----------- -------------------------------------------------- ------------xGVS---------------------------------- ----LRRH----------------------------------------KL VQD---------------------------------------------TL EGLRELLHIL---------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ---------------------H---------------------------- ------G------------------------------------------- ---LPAAVPVLP-------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- --------------------------------------------LELTVT CNFIILKVS--LAQGFTEDQAQDIQRGLER-------------------- --------------VLETQE-QLG---PRxEQGIRKL------------- --WESV-------------------------------------------- -------------------------------------------------L CASSLLPELLCALHHLAG-------------------------------- -------------------------------------------------- -------------------------------------LQA---------- -----------------------------------------------ALW LSIDRLEDLALL-------------------------------------- -------------------------------------LQTLNG------- ---------------NQ--------N---GAS------------------ --KDLLL-----LLKTWNPPAEE--------------------------- -------------------------------------------------- -------------SDAPLTLQNARGLRDILL------------------- ------------------------T--------------------AFAYR QGL--------QELISGSL----------------PRALSSLHEAASGLC SRPL------------------------------LVQVYTALGSCLRKMG -------------------------------------------------- ----------------NPQRAL-----LYLIAALKGGSPWGLPLLE---- -------------------------------------------------- ---------------------------ASRLYRQLGDT----------AA ELESLELLVEALSAT----HS---Sxx----------------------H SL----------------------------------IEVEL--------- -------------------------------------------------- -----------------LLPPPDPASPLYCGT------------------ -------------------------------------------------- -QSQAKHLL-----------------------------------ASRCLQ M------------------------------------------------- -------------------------------------------------- -----GRAED----------AAEHY------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ----------------------------------------LDL------- -------------------------------------------------- -------------------------------------------------- ---------------LALLL-DGS-------------------------- -------------------------------------------------- -------------------------xPR---------------------- -------------------------------------------------- -----------------------------------F------C------- -----PPTSPP-GPCMPEVFLEAAAALIQAGRAQDA-------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ----------------------------------------LTVCE----- -------------------------------------------------- -------------------------------------------------- -------ELLTRTSSL-----LPKMLQPW--------------------- ------EDARx--------------------------------------- -------------------------------------------------- -------------------------------------GT----------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- K------------------------------------------------- -----------------------------------------ELPS----- ---------CPLWVSA---------------------------------- -------------------------------------------------- -------------------------------------------------- ----VYLLQGRAWVQL--RAPKEAISEFSRCLELLFRA------------ ----------------------------xxx-DK---------------E Q------------------------------------------------- -------xS----------xxxxxxx------------------------ ------------xxM------------------A---------------- -----------------------LKQL----------------------- -------------------------------------------------- ----RAAALISRGLEWAAN------------------------------- ---------------------------GQDTKALQDFLLSV--------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- --QMCP-------------------------------------------- --------------------GNRDASFH---------------------- -----------------------------LLQTLRRL------------- -------------------------------------------------- --DRKNEAAAF---------------------C----------------- -------WRLQAQT-----QL-P----xxEAT----------W------- ------S-----------------------------------------LP LYLEIY-------------------------------------------- -------------------------------------------LSWIHSP DCETFLEE----------------------------------------FQ TSL----------------------------------------------- ---------------------------xxPRD-L---------------- -------- >ENSCLAP00000002590 -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ----------M-----------SxxS------------------------ ----------------------xx-xxxxx-------------------- xAS-------------CLDLWREENDRLVRRAK----------------- -------------------------------------------------- -------------------------------------------------- ----xRRQ----------------------------------------LL TQD---------------------------------------------VL EGLRGLLRSL---------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ---------------------Q---------------------------- ------G------------------------------------------- ---LPAAVPALP-------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- --------------------------------------------LELAVT CNVIILRVS--LSRVFPEDQAQGIRQALER-------------------- --------------VLETQE-QLG---PRxEQGLREL------------- --WDSV-------------------------------------------- -------------------------------------------------L RASALLPALLPALHLLAG-------------------------------- -------------------------------------------------- -------------------------------------LQA---------- -----------------------------------------------ALW LSTDRLGDLASM-------------------------------------- -------------------------------------LQTLNG------- ---------------SQ--------S---RAS------------------ --EDLLL-----LLKAWSPPAVE--------------------------- -------------------------------------------------- -------------SDAPLILQDAQGLKDVLL------------------- ------------------------T--------------------ASAFR QGL--------QELITGRL----------------PEALSNLQEAASSLC SRSV------------------------------LAQVYTALGNCLRKMG -------------------------------------------------- ----------------NPQRAL-----LYLIAALKEGSPLGPPLLE---- -------------------------------------------------- ---------------------------ASRLYQQLGDT----------TA ELESLELLAEALSVT----HS---SEA---------------------PQ IL----------------------------------IEVEL--------- -------------------------------------------------- -----------------LLPRPDPASPLHCGT------------------ -------------------------------------------------- -QSHVKHLL-----------------------------------ASRCLQ T------------------------------------------------- -------------------------------------------------- -----GRAED----------AAEHY------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ----------------------------------------LDL------- -------------------------------------------------- -------------------------------------------------- ---------------LALLF-DGS-------------------------- -------------------------------------------------- -------------------------xPR---------------------- -------------------------------------------------- -----------------------------------L------S------- -----PPLCPP-GPCMPELFLEAAVALITASRAQDA-------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ----------------------------------------LTVCE----- -------------------------------------------------- -------------------------------------------------- -------ELLSRTSFL-----LPKMHRLW--------------------- ------EDVRx--------------------------------------- -------------------------------------------------- -------------------------------------GT----------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- R------------------------------------------------- -----------------------------------------ELPH----- ---------CPLWVSA---------------------------------- -------------------------------------------------- -------------------------------------------------- ----AHLLQGQAWVQL--RAQKEAISEFSRCLELLFRA------------ ----------------------------xxx-DK---------------x x------------------------------------------------- -------xS----------xxxxxxx------------------------ ------------xxA------------------A---------------- -----------------------LQHL----------------------- -------------------------------------------------- ----RSAALISRGLEWAAS------------------------------- ---------------------------GQDSKALQDFFLSV--------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- --QMCP-------------------------------------------- --------------------GHRDASFH---------------------- -----------------------------LLQTLKKL------------- -------------------------------------------------- --NRKDEASAV---------------------W----------------- -------RRLKAQT-----QP-P----xxGAT----------W------- ------S-----------------------------------------LP LYLETY-------------------------------------------- -------------------------------------------LSWIHPP NCETLLEE----------------------------------------FQ TSL----------------------------------------------- ---------------------------xxPCDxL---------------- -------- >ENSODEP00000023024 -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ----------M-----------SxxT------------------------ ----------------------xx-xxxxx-------------------- xAS-------------CLDLWRERNDRLVRRAR----------------- -------------------------------------------------- ---------------xxxx------------------------------- xxxxLRRQ----------------------------------------QL IQD---------------------------------------------IL EGFRGVLYSL---------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ---------------------Q---------------------------- ------G------------------------------------------- ---LPAAVPLLP-------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- --------------------------------------------LELTVT CNFIILRVS--LTQGFNEDQAQCVQQALKR-------------------- --------------VLETQE-QLG---PRxDQGLREL------------- --WYSV-------------------------------------------- -------------------------------------------------L HVSSLLPDLLPALHLLAG-------------------------------- -------------------------------------------------- -------------------------------------LQA---------- -----------------------------------------------AHW LSTDHLGDTAWL-------------------------------------- -------------------------------------LQTLNG------- ---------------TQ--------S---RAS------------------ --EDLLL-----FLKTWSPPALE--------------------------- -------------------------------------------------- -------------SDASLILQDAQGLRNVLL------------------- ------------------------T--------------------ASALR QGL--------QELITGRL----------------PKALSSLQEAASSLC SRPV------------------------------LVQVYTALGNCLRRMG -------------------------------------------------- ----------------NPQRAL-----LYLIAALKEGSACGLPLLE---- -------------------------------------------------- ---------------------------ASRLYRQVGDT----------TA ELESLELLAEALSVT----YN---SEA---------------------PQ IL----------------------------------IEVEL--------- -------------------------------------------------- -----------------LLPRPDPASPLHCGT------------------ -------------------------------------------------- -QSQVKHLL-----------------------------------ASRCLQ T------------------------------------------------- -------------------------------------------------- -----GRAEA----------AAEHY------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ----------------------------------------LDL------- -------------------------------------------------- -------------------------------------------------- ---------------LALLL-DGS-------------------------- -------------------------------------------------- -------------------------xSR---------------------- -------------------------------------------------- -----------------------------------F------S------- -----PPSCPP-GPCMPEVFLEAALALIEAGRAQDA-------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ----------------------------------------LTVCE----- -------------------------------------------------- -------------------------------------------------- -------ELLSRTSFL-----LPKMPRMR--------------------- ------EDVRx--------------------------------------- -------------------------------------------------- -------------------------------------GT----------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- K------------------------------------------------- -----------------------------------------ELSH----- ---------CPLWVSA---------------------------------- -------------------------------------------------- -------------------------------------------------- ----AHLLQGQAWVQL--RVQKKAISEFTSCLELLFRT------------ ----------------------------xxx-DK---------------x x------------------------------------------------- -------xS----------xxxxxxx------------------------ ------------xxA------------------T---------------- -----------------------LQHL----------------------- -------------------------------------------------- ----RAAALISRGLEWLAN------------------------------- ---------------------------GQDTKALQDFLLSV--------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- --QMCP-------------------------------------------- --------------------GHRDASFH---------------------- -----------------------------LLQTLKKL------------- -------------------------------------------------- --NRRDEASAI---------------------W----------------- -------WRLKAQI-----QL-P----xxEAT----------W------- ------S-----------------------------------------LP LYLETY-------------------------------------------- -------------------------------------------LSWIHPP DCETLLEE----------------------------------------FQ TSI----------------------------------------------- ---------------------------xxPCD-L---------------- -------- >ENSCPOP00000010804 -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ----------M-----------SxxT------------------------ ----------------------xx-xxxxx-------------------- xAS-------------CLDLWREKNDRLVRQAK----------------- -------------------------------------------------- ---------------xxxx------------------------------- xxxxVRRQ----------------------------------------QL IQN---------------------------------------------IL QGLKEVLLSL---------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ---------------------Q---------------------------- ------G------------------------------------------- ---LPAAVPVLP-------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- --------------------------------------------LELTIT CNFIILRVS--LTRGFTEDQAQDIQQALKR-------------------- --------------VLETQE-RLG---PGxELGLREL------------- --WDTV-------------------------------------------- -------------------------------------------------L HASCLLPDLLPVLHLLAG-------------------------------- -------------------------------------------------- -------------------------------------LQA---------- -----------------------------------------------AFW LSTEHLGDLVSL-------------------------------------- -------------------------------------LQTLNG------- ---------------TQ--------S---RAS------------------ --EDLLL-----LLKTWSPPAAE--------------------------- -------------------------------------------------- -------------SSALLILQDARSLRDILL------------------- ------------------------T--------------------ASAFR QGL--------QELITGSL----------------PKALSSLQEAASSMC SRSV------------------------------LVQVYTALGNCLRKMG -------------------------------------------------- ----------------KPQRAL-----LYLIAALKEGSVWGPLLLE---- -------------------------------------------------- ---------------------------ASRLYRQQGDT----------TA ELESLELLTEALSVTx--xHS---SKA---------------------PQ VF----------------------------------IEVEL--------- -------------------------------------------------- -----------------LLTQPDPASPLHCGT------------------ -------------------------------------------------- -QSQIKHLL-----------------------------------ASRCLQ M------------------------------------------------- -------------------------------------------------- -----GRAED----------AAEHY------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ----------------------------------------LDL------- -------------------------------------------------- -------------------------------------------------- ---------------LALLL-DGS-------------------------- -------------------------------------------------- -------------------------xPR---------------------- -------------------------------------------------- -----------------------------------F------S------- -----PPSCPP-GPCMPEVFLEAALALIQASRAQDA-------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ----------------------------------------LTVCE----- -------------------------------------------------- -------------------------------------------------- -------ELLSRTSFL-----LPKMPRLW--------------------- ------EDVRx--------------------------------------- -------------------------------------------------- -------------------------------------GT----------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- K------------------------------------------------- -----------------------------------------EMPH----- ---------CPLWVSA---------------------------------- -------------------------------------------------- -------------------------------------------------- ----AHLLQGQAWVQL--RTQKEAVSEFSRCLELLFRV------------ ----------------------------xxx-DK---------------G Q----------------------------------------------xx- -------xS----------xxxxxxx------------------------ ------------xxM------------------T---------------- -----------------------LQHL----------------------- -------------------------------------------------- ----RAAALISRGLEWIAS------------------------------- ---------------------------GQDTKALQDFLLSV--------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- --QICP-------------------------------------------- --------------------GHRDASFH---------------------- -----------------------------LLQTLKKL------------- -------------------------------------------------- --NRKDEASAV---------------------W----------------- -------WKLKAPT-----QL-P----xxEAT----------R------- ------S-----------------------------------------LP LYLEAY-------------------------------------------- -------------------------------------------FNWIHPP DCETLLEE----------------------------------------FQ TSL----------------------------------------------- ---------------------------xxPx------------------- -------- >ENSHGLP00100000698 -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ----------x-----------Sxxx------------------------ ----------------------xx-------------------------- ----------------CLDLWREKNDRLVRRAK-xxxQK----------- -------------------------------------------------- ------------xGLH---------------------------------- ----LRRQ----------------------------------------QL TQD---------------------------------------------IL EGLSGLLHSL---------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ---------------------Q---------------------------- ------G------------------------------------------- ---LPAAVSVLP-------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- --------------------------------------------LELTVT CNFIILRAS--LTQGFTEDQAQDIQQALER-------------------- --------------VLETQE-PLV---PRxEQGLREL------------- --WDSV-------------------------------------------- -------------------------------------------------L HASSLLPELLPALHLLAG-------------------------------- -------------------------------------------------- -------------------------------------LQA---------- -----------------------------------------------ALW LSTDHLGDLALL-------------------------------------- -------------------------------------LQALNG------- ---------------SQ--------N---RAS------------------ --EDLLL-----LLKTWSPPAEE--------------------------- -------------------------------------------------- -------------SDAPLILQDAWGLRDVLL------------------- ------------------------T--------------------ASAFH QGL--------QELITGSL----------------PKALSSLHEAASGLC SRPV------------------------------LVQVYTALGNCLRKMG -------------------------------------------------- ----------------TPQRAL-----LYLIAALKEGSALGLPLLE---- -------------------------------------------------- ---------------------------ASRLYRQLGNT----------TA ELESLELLFEALSVT----HK---SEA---------------------PH IL----------------------------------IEVEL--------- -------------------------------------------------- -----------------LLPQPGPASPLHCGT------------------ -------------------------------------------------- -QSQVKHLL-----------------------------------ASRCLQ M------------------------------------------------- -------------------------------------------------- -----GRAEE----------AAEHY------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ----------------------------------------LDL------- -------------------------------------------------- -------------------------------------------------- ---------------LALLL-DVS-------------------------- -------------------------------------------------- -------------------------xPR---------------------- -------------------------------------------------- -----------------------------------F------S------- -----PPPCPP-GPCMPEVFLEAAVALIKAGRAQDA-------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ----------------------------------------LTVCE----- -------------------------------------------------- -------------------------------------------------- -------ELLSRTSSL-----LPKMSWLW--------------------- ------EDVRx--------------------------------------- -------------------------------------------------- -------------------------------------GT----------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- K------------------------------------------------- -----------------------------------------ELPH----- ---------CPLWVSA---------------------------------- -------------------------------------------------- -------------------------------------------------- ----AHLLQGQAWVQL--RAQKEAVGEFSHCLELLFRA------------ ----------------------------xxx-DK---------------D Q----------------------------------------------xx- -------xS----------xxxxxxx------------------------ ------------xxV------------------A---------------- -----------------------LQHL----------------------- -------------------------------------------------- ----RAAALISRGLEWVAS------------------------------- ---------------------------GQDTKALQDFLLSV--------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- --QVCP-------------------------------------------- --------------------GHRDASFH---------------------- -----------------------------LLQTLRNL------------- -------------------------------------------------- --NRRDEANAV---------------------W----------------- -------WKLKTQT-----QV-P----xxEAT----------W------- ------S-----------------------------------------LP LYLETY-------------------------------------------- -------------------------------------------LSWIHPP DCETLLEE----------------------------------------FQ TSL----------------------------------------------- ---------------------------xxSx------------------- -------- >ENSHGLP00000015427 -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ----------x-----------Sxxx------------------------ ----------------------xx-------------------------- ----------------CLDLWREKNDRLVRRAK-xxxQK----------- -------------------------------------------------- ------------xGLH---------------------------------- ----LRRQ----------------------------------------QL TQD---------------------------------------------IL EGLSGLLHSL---------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ---------------------Q---------------------------- ------G------------------------------------------- ---LPAAVSVLP-------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- --------------------------------------------LELTVT CNFIILRAS--LTQGFTEDQAQDIQQALER-------------------- --------------VLETQE-PLV---PRxEQGLREL------------- --WDSV-------------------------------------------- -------------------------------------------------L HASSLLPELLPALHLLAG-------------------------------- -------------------------------------------------- -------------------------------------LQA---------- -----------------------------------------------ALW LSTDHLGDLALL-------------------------------------- -------------------------------------LQALNG------- ---------------SQ--------N---RAS------------------ --EDLLL-----LLKTWSPPAEE--------------------------- -------------------------------------------------- -------------SDAPLILQDAWGLRDVLL------------------- ------------------------T--------------------ASAFH QGL--------QELITGSL----------------PKALSSLHEAASGLC SRPV------------------------------LVQVYTALGNCLRKMG -------------------------------------------------- ----------------NPQRAL-----LYLIAALKEGSALGLPLLE---- -------------------------------------------------- ---------------------------ASRLYRQLGNT----------TA ELESLELLFEALSVT----HK---SEA---------------------PH IL----------------------------------IEVEL--------- -------------------------------------------------- -----------------LLPQPGPASPLHCGT------------------ -------------------------------------------------- -QSQVKHLL-----------------------------------ASRCLQ M------------------------------------------------- -------------------------------------------------- -----GRAEE----------AAEHY------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ----------------------------------------LDL------- -------------------------------------------------- -------------------------------------------------- ---------------LALLL-DVS-------------------------- -------------------------------------------------- -------------------------xPR---------------------- -------------------------------------------------- -----------------------------------F------S------- -----PPPCPP-GPCMPEVFLEAAVALIKAGRAQDA-------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ----------------------------------------LTVCE----- -------------------------------------------------- -------------------------------------------------- -------ELLSRTSSL-----LPKMSWLW--------------------- ------EDVRx--------------------------------------- -------------------------------------------------- -------------------------------------GT----------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- K------------------------------------------------- -----------------------------------------ELPH----- ---------CPLWVSA---------------------------------- -------------------------------------------------- -------------------------------------------------- ----AHLLQGQAWVQL--RAQKEAVGEFSHCLELLFRA------------ ----------------------------xxx-DK---------------D Q----------------------------------------------xx- -------xS----------xxxxxxx------------------------ ------------xxV------------------A---------------- -----------------------LQHL----------------------- -------------------------------------------------- ----RAAALISRGLEWVAS------------------------------- ---------------------------GQDTKALQDFLLSV--------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- --QVCP-------------------------------------------- --------------------GHRDASFH---------------------- -----------------------------LLQTLRNL------------- -------------------------------------------------- --NRRDEANAV---------------------W----------------- -------WKLKTQT-----QV-P----xxEAT----------W------- ------S-----------------------------------------LP LYLETY-------------------------------------------- -------------------------------------------LSWIHPP DCETLLEE----------------------------------------FQ TSL----------------------------------------------- ---------------------------xxSx------------------- -------- >ENSOCUP00000005572 -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ----------M-----------SxxT------------------------ ----------------------xx-xxxxx-------------------- xAS-------------CLDLWKDKNNRLVRQVQ-Vx-QG----------- -------------------------------------------------- ------------xGLS---------------------------------- ----LRRQ----------------------------------------RL AQD---------------------------------------------TL EGLRELLHSL---------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ---------------------Q---------------------------- ------G------------------------------------------- ---LPAAVRVLQ-------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- --------------------------------------------LELTVT CNFIILRVG--LAQGFTEDQAQDIQRGLER-------------------- --------------VLEIQE-QPG---PRxEREPMEL------------- --WNSV-------------------------------------------- -------------------------------------------------F RASCLVPELLPALHQLVG-------------------------------- -------------------------------------------------- -------------------------------------LQA---------- -----------------------------------------------ALW LSADRLQDLALL-------------------------------------- -------------------------------------LKALNG------- ---------------SQ--------S---GTS------------------ --EDLLL-----LLKTWRPPAEE--------------------------- -------------------------------------------------- -------------SDAPLTLQTARGLRDVVL------------------- ------------------------T--------------------AFAYR QGL--------RELNTGNL----------------PEALGSLHEAASGLC SRPL------------------------------LVQVYTAVGTCFRKMG -------------------------------------------------- ----------------HPQRAL-----LYLTAALKEGSALGPPLLE---- -------------------------------------------------- ---------------------------ASRLYRQLGDT----------AA ELESLELLVEALSIA----HS---SEA---------------------PQ LL----------------------------------IDVEL--------- -------------------------------------------------- -----------------LLPLPDAASPLHCGT------------------ -------------------------------------------------- -QSQAKHLL-----------------------------------ASRCLQ T------------------------------------------------- -------------------------------------------------- -----ERAED----------AAEHY------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ----------------------------------------LDL------- -------------------------------------------------- -------------------------------------------------- ---------------LALLL-DCS-------------------------- -------------------------------------------------- -------------------------xSR---------------------- -------------------------------------------------- -----------------------------------F------S------- -----PPPCPP-GPCVPELFLEAAAALIQAGRAQDA-------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ----------------------------------------LTVCE----- -------------------------------------------------- -------------------------------------------------- -------ELLRRTSSL-----LPKTSLLS--------------------- ------ENARx--------------------------------------- -------------------------------------------------- -------------------------------------GA----------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- R------------------------------------------------- -----------------------------------------ELPH----- ---------CPLWVSA---------------------------------- -------------------------------------------------- -------------------------------------------------- ----THLLQGQAWAKL--GAQKEAVSEFSRCLELLFRA------------ ----------------------------xxx-DR---------------E Q----------------------------------------------xx- -------xS----------xxxxxxx------------------------ ------------xxV------------------T---------------- -----------------------LQQL----------------------- -------------------------------------------------- ----RTAALISRGLQWVAS------------------------------- ---------------------------GHDAKALQDFLLGV--------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- --QICP-------------------------------------------- --------------------GNQDASFY---------------------- -----------------------------LLQTLWRQ------------- -------------------------------------------------- --DRRDEAAAL---------------------W----------------- -------RRLEAQT-----KS-P----xxDAT----------W------- ------S-----------------------------------------LP LYLETC-------------------------------------------- -------------------------------------------LSWIRPS DRQTFLEE----------------------------------------FQ VSV----------------------------------------------- ---------------------------xxPRD-V---------------- -------- >ENSRNOP00000069926 -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ----------M-----------SxxI------------------------ ----------xxxxxx---xx----------------------------- -SS-------------SLDLWREKNDQLVRQAKQLx-RD----------- -------------------------------------------------- ------------xRPS---------------------------------- ----LRRQ----------------------------------------QS VQD---------------------------------------------TL EGFRELLLTL---------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ---------------------Q---------------------------- ------G------------------------------------------- ---LPAAVPALP-------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- --------------------------------------------LELTVT CNYIILRAS--LAQGFTEDLTEDVQRGLER-------------------- --------------VLEAQH-QMG---SKxQQGLKEL------------- --WHSV-------------------------------------------- -------------------------------------------------L SAPSLLPELLPALHCLAS-------------------------------- -------------------------------------------------- -------------------------------------LHA---------- -----------------------------------------------ALW MSTNHLGDLTSL-------------------------------------- -------------------------------------LQTLNG------- ---------------SQ--------T---ETS------------------ --EDLLP-----LLKSWSPPVEK--------------------------- -------------------------------------------------- -------------LHAPLILQDAESLKDVLL------------------- ------------------------T--------------------AFACR QGF--------QELITGSL----------------PHAQSSLQEAASGLC PPSV------------------------------LVQVYTALGTCLRKMG -------------------------------------------------- ----------------SPQRAL-----LYLTEALKVGTTCALPLLE---- -------------------------------------------------- ---------------------------ASRVYRQLGDT----------AA ELESLQLLVEALSAT----HS---xET---------------------FT RL----------------------------------IEVEL--------- -------------------------------------------------- -----------------LLPQPDPASPLHCGT------------------ -------------------------------------------------- -QSQAKHLL-----------------------------------ASRCLQ T------------------------------------------------- -------------------------------------------------- -----GRAEA----------AAEHY------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ----------------------------------------LDL------- -------------------------------------------------- -------------------------------------------------- ---------------LAMLL-DGS-------------------------- -------------------------------------------------- -------------------------xPR---------------------- -------------------------------------------------- -----------------------------------S------S------- -----PPTSAL-GPCMPELCLEAAAALIQAGRASDA-------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ----------------------------------------LTVCV----- -------------------------------------------------- -------------------------------------------------- -------ELLSRTSSL-----LPKMPSLW--------------------- ------ENASx--------------------------------------- -------------------------------------------------- -------------------------------------RT----------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- K------------------------------------------------- -----------------------------------------ELPY----- ---------CPIWASA---------------------------------- -------------------------------------------------- -------------------------------------------------- ----THLLQGQAWSQL--KAQKEALSEFSQCLELLFRA------------ ----------------------------xxx-DK---------------E Q----------------------------------------------x-- --------S----------xxxxxxx------------------------ ------------xxV------------------S---------------- -----------------------LKQL----------------------- -------------------------------------------------- ----RVAALISRGLEWVAI------------------------------- ---------------------------GQDTKALSDFLLSV--------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- --QICP-------------------------------------------- --------------------GNRDGSFY---------------------- -----------------------------LLQTLKRL------------- -------------------------------------------------- --DRKNEASAF---------------------W----------------- -------R--EAQS-----QL-P----xxEAA----------R------- ------C-----------------------------------------LP LYLETC-------------------------------------------- -------------------------------------------LNWIHPP NCEAFFEE----------------------------------------FG TAV----------------------------------------------- ---------------------------xxSCD-L---------------- -------- >ENSMUSP00000030165 -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ----------M-----------SxxV------------------------ ----------xxxxxx---xx----------------------------- -SS-------------SLDLWREKNDQLVRQAKQLx-RD----------- -------------------------------------------------- ------------xRPS---------------------------------- ----LRRQ----------------------------------------QS AQD---------------------------------------------TL EGLRELLLTL---------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ---------------------Q---------------------------- ------G------------------------------------------- ---LPAAVPALP-------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- --------------------------------------------LELTVL CNCIILRAS--LVQAFTEDLTQDLQRGLER-------------------- --------------VLEAQH-HLE---PKxQQGLKEL------------- --WHSV-------------------------------------------- -------------------------------------------------L SASSLPPELLPALHCLAS-------------------------------- -------------------------------------------------- -------------------------------------LQA---------- -----------------------------------------------VFW MSTDHLEDLTLL-------------------------------------- -------------------------------------LQTLNG------- ---------------SQ--------T---QSS------------------ --EDLLL-----LLKSWSPPAEE--------------------------- -------------------------------------------------- -------------SPAPLILQDAESLRDVLL------------------- ------------------------T--------------------AFACR QGF--------QELITGSL----------------PHAQSNLHEAASGLC PPSV------------------------------LVQVYTALGACLRKMG -------------------------------------------------- ----------------NPQRAL-----LYLTEALKVGTTCALPLLE---- -------------------------------------------------- ---------------------------ASRVYRQLGDR----------AA ELESLELLVEALSAT----HS---xET---------------------FK SL----------------------------------IEVEL--------- -------------------------------------------------- -----------------LLPQPDPASPLHCGT------------------ -------------------------------------------------- -QSQAKHLL-----------------------------------ASRCLQ T------------------------------------------------- -------------------------------------------------- -----GRAED----------AAEHY------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ----------------------------------------LDL------- -------------------------------------------------- -------------------------------------------------- ---------------LAMLL-GGS-------------------------- -------------------------------------------------- -------------------------xTR---------------------- -------------------------------------------------- -----------------------------------F------S------- -----PPTSSL-GPCIPELCLEAAAALIQAGRALDA-------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ----------------------------------------LTVCE----- -------------------------------------------------- -------------------------------------------------- -------ELLNRTSSL-----LPKMSSLW--------------------- ------ENARx--------------------------------------- -------------------------------------------------- -------------------------------------RA----------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- K------------------------------------------------- -----------------------------------------ELPC----- ---------CPVWVSA---------------------------------- -------------------------------------------------- -------------------------------------------------- ----THLLQGQAWSQL--KAQKEALSEFSQCLELLFRT------------ ----------------------------xxx-DK---------------E Q----------------------------------------------x-- --------S----------xxxxxxx------------------------ ------------xxV------------------A---------------- -----------------------LKQL----------------------- -------------------------------------------------- ----RVAALISRGLEWVAS------------------------------- ---------------------------GQDTKALSDFLLSV--------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- --QICP-------------------------------------------- --------------------GNRDGSFY---------------------- -----------------------------LLQTLKRL------------- -------------------------------------------------- --DRKNEASAF---------------------W----------------- -------R--EAHS-----QL-P----xxDAA----------G------- ------S-----------------------------------------LP LYLETC-------------------------------------------- -------------------------------------------LSWIHPP NREAFLEE----------------------------------------FG TSV----------------------------------------------- ---------------------------xxSCV-L---------------- -------- >MGP_SPRETEiJ_P0064373 -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ----------M-----------SxxV------------------------ ----------xxxxxx---xx----------------------------- -SS-------------SLDLWRGKNDQLVRQAKQLx-RD----------- -------------------------------------------------- ------------xRPS---------------------------------- ----LRRQ----------------------------------------QL AQD---------------------------------------------TL EGLRELLLTL---------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ---------------------Q---------------------------- ------G------------------------------------------- ---LPAAVPALP-------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- --------------------------------------------LELTVL CNCIILRAS--LVQAFTEDLTQDLQRGLER-------------------- --------------VLEAQH-HLE---PKxQQGLKEL------------- --WHSV-------------------------------------------- -------------------------------------------------L SASSLPPELLPALHCLAS-------------------------------- -------------------------------------------------- -------------------------------------LQA---------- -----------------------------------------------VFW MSTDHLEDLTLL-------------------------------------- -------------------------------------LQTLNG------- ---------------SQ--------T---QSS------------------ --EDLLL-----LLKSWSPPAEE--------------------------- -------------------------------------------------- -------------SPAPLILQDAESLRDVLL------------------- ------------------------T--------------------AFACR QGF--------QELITGSL----------------PHAQSSLHEAASGLC PPSV------------------------------LVQVYTALGTCLRKMG -------------------------------------------------- ----------------NPQRAL-----LYLTEALKVGTTCALPLLE---- -------------------------------------------------- ---------------------------ASRIYRQLGDR----------AA ELESLELLVEALSAT----HS---xET---------------------FK SL----------------------------------IEVEL--------- -------------------------------------------------- -----------------LLPQPDPASPLHCGT------------------ -------------------------------------------------- -QSQAKHLL-----------------------------------ASRCLQ T------------------------------------------------- -------------------------------------------------- -----GRAED----------AAEHY------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ----------------------------------------LDL------- -------------------------------------------------- -------------------------------------------------- ---------------LAMLL-GGS-------------------------- -------------------------------------------------- -------------------------xTR---------------------- -------------------------------------------------- -----------------------------------F------S------- -----PPTSSL-GPCIPELCLEAAAALIQAGRALDA-------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ----------------------------------------LTVCE----- -------------------------------------------------- -------------------------------------------------- -------ELLNRTSSL-----LPKMSSLW--------------------- ------ENARx--------------------------------------- -------------------------------------------------- -------------------------------------RT----------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- K------------------------------------------------- -----------------------------------------ELPC----- ---------CPVWVSA---------------------------------- -------------------------------------------------- -------------------------------------------------- ----THLLQGQAWSQL--KAQKEALSEFSQCLELLFRT------------ ----------------------------xxx-DK---------------E Q----------------------------------------------x-- --------S----------xxxxxxx------------------------ ------------xxV------------------A---------------- -----------------------LKRL----------------------- -------------------------------------------------- ----RVAALISRGLEWVAS------------------------------- ---------------------------GQDTKALSDFLLSV--------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- --QICP-------------------------------------------- --------------------GNRDGSFY---------------------- -----------------------------LLQTLKRL------------- -------------------------------------------------- --DRKNEASAF---------------------W----------------- -------R--EAHS-----QL-P----xxDAA----------G------- ------S-----------------------------------------LP LYLETC-------------------------------------------- -------------------------------------------LSWIHPP NREAFLEE----------------------------------------FG TSV----------------------------------------------- ---------------------------xxSCD-L---------------- -------- >MGP_CAROLIEiJ_P0061909 -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ----------M-----------SxxV------------------------ ----------xxxxxx---xx----------------------------- -SS-------------SLDLWREKNDQLVKQAKQLx-RD----------- -------------------------------------------------- ------------xRPS---------------------------------- ----LRRQ----------------------------------------QS AQN---------------------------------------------TL EGLRELLLTL---------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ---------------------Q---------------------------- ------G------------------------------------------- ---LPAAVPALP-------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- --------------------------------------------LELTVL CNCIILRAS--LVQAFTEDLTQDLQRGLER-------------------- --------------VLEAQH-HLE---PKxQQGLKEL------------- --WHSV-------------------------------------------- -------------------------------------------------L SASSLPPELLPALHCLAS-------------------------------- -------------------------------------------------- -------------------------------------LQA---------- -----------------------------------------------VFW MSTDRLEDLSLL-------------------------------------- -------------------------------------LQTLNG------- ---------------SQ--------T---ETS------------------ --EDLLL-----LLKSWSPPAEE--------------------------- -------------------------------------------------- -------------SHAPLILQDAQSLRDVLL------------------- ------------------------T--------------------AFACR QGF--------QELITGSL----------------PHAQSSLHEAASGLC PPSV------------------------------LVQVYTALGTCLRKMG -------------------------------------------------- ----------------NPQRAL-----LYLTEALKVGTACALPLLE---- -------------------------------------------------- ---------------------------ASRVYRQLGDR----------AA ELESLGLLVEALSAT----HS---xET---------------------FK SL----------------------------------IEVES--------- -------------------------------------------------- -----------------LLPQPDPASPLHCGT------------------ -------------------------------------------------- -QSQAKHLL-----------------------------------ASRCLQ T------------------------------------------------- -------------------------------------------------- -----GRAED----------AAEHY------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ----------------------------------------LDL------- -------------------------------------------------- -------------------------------------------------- ---------------LAMLL-GGS-------------------------- -------------------------------------------------- -------------------------xTR---------------------- -------------------------------------------------- -----------------------------------F------S------- -----PPTSSL-GPCIPELCLEAAAALIQAGRALDA-------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ----------------------------------------LTVCE----- -------------------------------------------------- -------------------------------------------------- -------ELLNRTSSL-----LPKMSSLW--------------------- ------ENARx--------------------------------------- -------------------------------------------------- -------------------------------------RT----------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- K------------------------------------------------- -----------------------------------------ELPC----- ---------CPVWVSA---------------------------------- -------------------------------------------------- -------------------------------------------------- ----THLLQGQAWSQL--KAQKEALSEFSQCLELLFRT------------ ----------------------------xxx-DK---------------E Q----------------------------------------------x-- --------S----------xxxxxxx------------------------ ------------xxV------------------A---------------- -----------------------LKQL----------------------- -------------------------------------------------- ----RVAALISRGLEWVAS------------------------------- ---------------------------GQDTKALSDFLLSV--------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- --QICP-------------------------------------------- --------------------GNRDGSFY---------------------- -----------------------------LLQTLRRL------------- -------------------------------------------------- --ERKNEASVF---------------------W----------------- -------R--EARS-----QL-P----xxDAA----------G------- ------S-----------------------------------------LP LYLETC-------------------------------------------- -------------------------------------------LSWIHPP NREAFLEE----------------------------------------FG TSV----------------------------------------------- ---------------------------xxSCD-L---------------- -------- >MGP_PahariEiJ_P0057633 -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ----------M-----------SxxI------------------------ ----------xxxxxx---xx----------------------------- -SS-------------SLDLWREKNDQLVRQAKRLx-RD----------- -------------------------------------------------- ------------xRPS---------------------------------- ----LRRQ----------------------------------------QS AQD---------------------------------------------TL EGFRELLLTL---------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ---------------------R---------------------------- ------G------------------------------------------- ---LPAAVPALP-------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- --------------------------------------------LELTVL CNCIILRVS--LAQGLTEDLTQELQRGLER-------------------- --------------VLEAQH-HLE---LKxQQGLKEL------------- --WHSV-------------------------------------------- -------------------------------------------------L SAYPLPPELLPALHCLAS-------------------------------- -------------------------------------------------- -------------------------------------LQA---------- -----------------------------------------------VSW MSTDRLQDLTLL-------------------------------------- -------------------------------------LQTLNG------- ---------------SQ--------T---ETS------------------ --EDLLL-----LLKSWSPPAEE--------------------------- -------------------------------------------------- -------------SHGPLILQDAESLRGVLL------------------- ------------------------T--------------------AFACR QGF--------QELSTGNL----------------PHAQSSLHEAASGLC PPSV------------------------------LVQVYTALGTCLRKMG -------------------------------------------------- ----------------NPQRAL-----LYLTEALKVGTTCALPLLE---- -------------------------------------------------- ---------------------------ASRVYRQLGDT----------AA ELESLELLVEALSVT----HS---xET---------------------FK SL----------------------------------IEVEL--------- -------------------------------------------------- -----------------LLPQPDPASPLHGGT------------------ -------------------------------------------------- -RSQAKHLL-----------------------------------ASRCLQ M------------------------------------------------- -------------------------------------------------- -----GRAED----------AAEHY------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ----------------------------------------LDL------- -------------------------------------------------- -------------------------------------------------- ---------------LAVLL-GGS-------------------------- -------------------------------------------------- -------------------------xPR---------------------- -------------------------------------------------- -----------------------------------F------S------- -----PPTSSL-GPCVPELCLEAAAALIQAGRASDA-------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ----------------------------------------LTVCE----- -------------------------------------------------- -------------------------------------------------- -------ELLNRTSSL-----LPKMSSLW--------------------- ------ENARx--------------------------------------- -------------------------------------------------- -------------------------------------RT----------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- K------------------------------------------------- -----------------------------------------ELPC----- ---------CPVWVSA---------------------------------- -------------------------------------------------- -------------------------------------------------- ----THLLQGQAWSRL--KAQKEALSEFSQCLELLFRT------------ ----------------------------xxx-DK---------------E Q----------------------------------------------x-- --------S----------xxxxxxx------------------------ ------------xxV------------------A---------------- -----------------------LRQL----------------------- -------------------------------------------------- ----RVAALISRGLEWVAS------------------------------- ---------------------------GQDTKALNDFLLSV--------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- --QTCP-------------------------------------------- --------------------GNRDGSFY---------------------- -----------------------------LLQTLKRL------------- -------------------------------------------------- --DRKNEASAF---------------------W----------------- -------R--EAHS-----QL-P----xxDAA----------G------- ------S-----------------------------------------LP LYLETC-------------------------------------------- -------------------------------------------LSWIHPP NREAFLEE----------------------------------------FG TSV----------------------------------------------- ---------------------------xxSCD-L---------------- -------- >ENSMOCP00000004061 -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ----------M-----------SxxI------------------------ ----------xxxxxx---x------------------------------ -SS-------------ILDLWREKNDRLVRQAKQLx-GD----------- -------------------------------------------------- ------------xRPS---------------------------------- ----LRRQ----------------------------------------QL AQD---------------------------------------------TL EGFKELLITL---------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ---------------------Q---------------------------- ------G------------------------------------------- ---LPAAVPALP-------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- --------------------------------------------LELTVT CNYIILRAS--LAQDFTEDLTQDIQRALER-------------------- --------------VLETQN-QLE---PKxQQRLPEL------------- --WHSV-------------------------------------------- -------------------------------------------------L SASSLLPELLPALYCLAS-------------------------------- -------------------------------------------------- -------------------------------------LQA---------- -----------------------------------------------ILW MSTNHPGDLALL-------------------------------------- -------------------------------------LQTLNA------- ---------------SQ--------T---ETS------------------ --EDLLL-----LLKSWSPPAEK--------------------------- -------------------------------------------------- -------------ADAPLSIQNAESLRDVLL------------------- ------------------------T--------------------AFACR QGL--------QELITGSL----------------PRALSSLHEAASGLC PPSV------------------------------LVQVYTALGTCLRKMG -------------------------------------------------- ----------------NPQRAL-----LYLTAALKVGATCALPLLE---- -------------------------------------------------- ---------------------------ASRIYRQLGDT----------AA ELESLELLAEALSAP----HSxxxSST---------------------LK LV----------------------------------IEVEL--------- -------------------------------------------------- -----------------LLPQPGPASPLHCGT------------------ -------------------------------------------------- -QSQAKHLL-----------------------------------ASRCLQ T------------------------------------------------- -------------------------------------------------- -----GRAED----------ASEHY------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ----------------------------------------LDL------- -------------------------------------------------- -------------------------------------------------- ---------------LAMLL-GGS-------------------------- -------------------------------------------------- -------------------------xPG---------------------- -------------------------------------------------- -----------------------------------F------S------- -----PPTSST-GPCIPELCLEAAAALIQAGRAQDA-------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ----------------------------------------LTVCE----- -------------------------------------------------- -------------------------------------------------- -------ELLSRTSSL-----LPKM-SLW--------------------- ------ENARx--------------------------------------- -------------------------------------------------- -------------------------------------RA----------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- K------------------------------------------------- -----------------------------------------ELPY----- ---------CPFWVSA---------------------------------- -------------------------------------------------- -------------------------------------------------- ----THLLQGQAWSQL--KAQKEALSEFSQCLELLFRA------------ ----------------------------xxx-DK---------------E Q----------------------------------------------x-- --------S----------xxxxxxx------------------------ ------------xxV------------------T---------------- -----------------------LKHL----------------------- -------------------------------------------------- ----QVAALLSRGLEWAAS------------------------------- ---------------------------NQDTKALSDFLLSV--------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- --QICP-------------------------------------------- --------------------GNRDGSFY---------------------- -----------------------------LLQTLKRL------------- -------------------------------------------------- --ERKNEAAAF---------------------W----------------- -------Q--xAQT-----QP-A----xxEAT----------W------- ------S-----------------------------------------LP LYLETC-------------------------------------------- -------------------------------------------LSWIHPP NCEALLEE----------------------------------------FG TSL----------------------------------------------- ---------------------------xxSCD-L---------------- -------- >ENSPEMP00000006928 -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ----------M-----------CxxI------------------------ ----------xxxxxx---xx----------------------------- -SS-------------SLDLWREKNDRLVGQTRQLx-GD----------- -------------------------------------------------- ------------xRPS---------------------------------- ----LRRQ----------------------------------------QL AQD---------------------------------------------TL EGFRELLLTL---------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ---------------------Q---------------------------- ------G------------------------------------------- ---LPAALPALP-------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- --------------------------------------------LELTVT CNYIILRAS--LAQGFTEDLIKDVQRGLER-------------------- --------------VMETQN-QLE---PKxQQGLQEL------------- --WHSV-------------------------------------------- -------------------------------------------------L SASSLLPELLPTLHCLAS-------------------------------- -------------------------------------------------- -------------------------------------LQA---------- -----------------------------------------------VLW MRTDCSGDLALL-------------------------------------- -------------------------------------LQALNG------- ---------------SQ--------T---ETS------------------ --EDLLL-----LLKSWSPPAEK--------------------------- -------------------------------------------------- -------------SDGPLILQDAQGLRDVLL------------------- ------------------------T--------------------ALACR QGL--------QELITGSL----------------PRALNSLHEAASGLC PPSV------------------------------LVQVYTALGTCLRKMG -------------------------------------------------- ----------------NPQRAL-----LYLTAALKVGTTCALPLLE---- -------------------------------------------------- ---------------------------ASRIYRQLGDT----------AA ELESLELLVEALSAT----HGx---KM---------------------LR LL----------------------------------IEVEL--------- -------------------------------------------------- -----------------LLPQPDPASPLHCGT------------------ -------------------------------------------------- -QSQAKHLL-----------------------------------ASRCLQ T------------------------------------------------- -------------------------------------------------- -----GRAGD----------AAEHY------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ----------------------------------------LDL------- -------------------------------------------------- -------------------------------------------------- ---------------LAVLLxGGS-------------------------- -------------------------------------------------- -------------------------xPR---------------------- -------------------------------------------------- -----------------------------------V------S------- -----PPTCSP-GPCVPELCLEAAAALIQAGRAPDA-------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ----------------------------------------LTVCG----- -------------------------------------------------- -------------------------------------------------- -------ELLSRTSCL-----LPKM-xxW--------------------- ------ENARx--------------------------------------- -------------------------------------------------- -------------------------------------RT----------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- K------------------------------------------------- -----------------------------------------GLPY----- ---------CPLWVSA---------------------------------- -------------------------------------------------- -------------------------------------------------- ----THLLQGQAWSQL--KAQKEALSEFSQCLELLFRV------------ ----------------------------xxx-DK---------------E Q----------------------------------------------x-- --------S----------xxxxxxx------------------------ ------------xxV------------------V---------------- -----------------------LKQL----------------------- -------------------------------------------------- ----QVAALLSRGLEWAAS------------------------------- ---------------------------GQDTKALSDFLLSV--------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- --QICP-------------------------------------------- --------------------GNRDGSFY---------------------- -----------------------------LLQTLKRS------------- -------------------------------------------------- --KRKNEATAF---------------------W----------------- -------R--EAQT-----RA-P----xxEAT----------W------- ------S-----------------------------------------LP LYLETC-------------------------------------------- -------------------------------------------LSWIHPP NCEALLEE----------------------------------------FG TSL----------------------------------------------- ---------------------------xxSHD-L---------------- -------- >ENSMAUP00000013640 -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ----------M-----------SxxI------------------------ ----------xxxxxx---xx----------------------------- -SS-------------SLDLWREKNNRLVEQARQLx-GD----------- -------------------------------------------------- ------------xRLS---------------------------------- ----LRRQ----------------------------------------QL AQD---------------------------------------------TL EEFGELLLTL---------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ---------------------Q---------------------------- ------G------------------------------------------- ---LPASVPALP-------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- --------------------------------------------LELTVI CNYIILKAS--LAQGFTEDLTQDVQRGVER-------------------- --------------VLETQN-QLE---PKxQQGLQGL------------- --WHSV-------------------------------------------- -------------------------------------------------L SASSLLPELLPALHCLAS-------------------------------- -------------------------------------------------- -------------------------------------LQA---------- -----------------------------------------------ILW MSTDHLGDLALL-------------------------------------- -------------------------------------LKTLNG------- ---------------IQ--------T---ETS------------------ --EDLLL-----LLKSWSPPAEK--------------------------- -------------------------------------------------- -------------SDAPLILQDAEGLRDVLL------------------- ------------------------T--------------------ALACH QGL--------QELITGNL----------------PQALSRLHEAASGVC PPSV------------------------------LAQVYTALGTCQRKMG -------------------------------------------------- ----------------NPQRAL-----LYLTAALKVGVTCALPLLE---- -------------------------------------------------- ---------------------------ASRLYRQLGDT----------AA ELESLQLLVEAL--------xxxxxxA---------------------LK LH----------------------------------IEVEL--------- -------------------------------------------------- -----------------LLPQPDPSSPLYCGT------------------ -------------------------------------------------- -QSQAKRLL-----------------------------------ASRCLQ T------------------------------------------------- -------------------------------------------------- -----GRAED----------AAEHY------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ----------------------------------------LDL------- -------------------------------------------------- -------------------------------------------------- ---------------LAVLL-GGS-------------------------- -------------------------------------------------- -------------------------xLR---------------------- -------------------------------------------------- -----------------------------------S------S------- -----PPTSSP-GPCIPELCLEAAAALIQAGRAPDA-------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ----------------------------------------LTVCE----- -------------------------------------------------- -------------------------------------------------- -------ELLSRTSSL-----LPKM-SLW--------------------- ------ENARx--------------------------------------- -------------------------------------------------- -------------------------------------RT----------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- K------------------------------------------------- -----------------------------------------ELPY----- ---------CPIWVSA---------------------------------- -------------------------------------------------- -------------------------------------------------- ----THLLQGQAWSQL--KARKEALSEFSQCLELLFRA------------ ----------------------------xxx-DK---------------E Q----------------------------------------------x-- --------S----------xxxxxxx------------------------ ------------xxV------------------A---------------- -----------------------LKQL----------------------- -------------------------------------------------- ----QVATLLSRGLEWVAS------------------------------- ---------------------------GQDTKALSDFLLSV--------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- --QICP-------------------------------------------- --------------------GNRDGSFY---------------------- -----------------------------LLQTLKRL------------- -------------------------------------------------- --ERRSEATAF---------------------W----------------- -------R--EAQN-----QQ-L----xxNAT----------R------- ------S-----------------------------------------LP LYLETC-------------------------------------------- -------------------------------------------LSWIHPP NCEAFLKE----------------------------------------FG ASL----------------------------------------------- ---------------------------xxSRD-L---------------- -------- >ENSCGRP00001021341 -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ----------x--------------------------------------- -----------xxxxx---xx----------------------------- -SS-------------TLDLWKDKNDRLVEQARQLx-GG----------- -------------------------------------------------- ------------xRLS---------------------------------- ----LRRQ----------------------------------------QL AQD---------------------------------------------TL EGFRELLLTL---------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ---------------------Q---------------------------- ------G------------------------------------------- ---LPAAVPALP-------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- --------------------------------------------LELTVI CNYIILGAS--LAQGFTEDLTQDVQRGLER-------------------- --------------VLETQS-QLE---PKxQQGLQGL------------- --WHSV-------------------------------------------- -------------------------------------------------L SASSLLPKLLPALHCLAS-------------------------------- -------------------------------------------------- -------------------------------------LQA---------- -----------------------------------------------IFW MCTDHLGDLALL-------------------------------------- -------------------------------------LQTLNG------- ---------------IQ--------T---ETS------------------ --EDLLL-----LIKSWSPPPEK--------------------------- -------------------------------------------------- -------------SDAPLILQDAEGLRDVLL------------------- ------------------------T--------------------TLACR QGL--------QELITGSL----------------PRALSRLHEAASGVC PPSV------------------------------LVQVYTALGTCLRKMG -------------------------------------------------- ----------------NPQRAL-----LYLTAALKVGTTCALPLLE---- -------------------------------------------------- ---------------------------ASRIYRQLGDT----------AA ELESLELLVEALSAT----HSxxxSST---------------------LK FH----------------------------------IEVEL--------- -------------------------------------------------- -----------------LLPKPDPASPLHCGT------------------ -------------------------------------------------- -QSQAKRLL-----------------------------------ASRCLQ T------------------------------------------------- -------------------------------------------------- -----GRAED----------AAEHY------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ----------------------------------------LDL------- -------------------------------------------------- -------------------------------------------------- ---------------LAMLL-GSS-------------------------- -------------------------------------------------- -------------------------xPR---------------------- -------------------------------------------------- -----------------------------------F------S------- -----LPTSSP-GPCIPELCLEAAAALIQASRAPDA-------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ----------------------------------------LTVCE----- -------------------------------------------------- -------------------------------------------------- -------ELLSRISSL-----IPKT-SLW--------------------- ------ENARx--------------------------------------- -------------------------------------------------- -------------------------------------RT----------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- K------------------------------------------------- -----------------------------------------ELPY----- ---------CPIWISA---------------------------------- -------------------------------------------------- -------------------------------------------------- ----THLLQGQAWSQL--KARKEALSEFSQCLELLFRA------------ ----------------------------xxx-DK---------------E Q----------------------------------------------x-- --------S----------xxxxxxx------------------------ ------------xxV------------------A---------------- -----------------------LKQL----------------------- -------------------------------------------------- ----QVAALLSRGLEWIAS------------------------------- ---------------------------GQDTKALSDFLLSV--------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- --QICP-------------------------------------------- --------------------GNRDGSFY---------------------- -----------------------------LLQTLKRL------------- -------------------------------------------------- --ERRNEAAAF---------------------W----------------- -------R--EAQN-----QP-L----xxEAT----------W------- ------S-----------------------------------------LP LYLETC-------------------------------------------- -------------------------------------------LSWIHPP NCEALLKE----------------------------------------FG TSL----------------------------------------------- ---------------------------------x---------------- -------- >ENSCGRP00015004074 -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ----------x--------------------------------------- -----------xxxxx---xx----------------------------- -SS-------------TLDLWKDKNDRLVEQARQLx-GG----------- -------------------------------------------------- ------------xRLS---------------------------------- ----LRRQ----------------------------------------QL AQD---------------------------------------------TL EGFRELLLTL---------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ---------------------Q---------------------------- ------G------------------------------------------- ---LPAAVPALP-------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- --------------------------------------------LELTVI CNYIILGAS--LAQGFTEDLTQDVQRGLER-------------------- --------------VLETQS-QLE---PKxQQGLQGL------------- --WHSV-------------------------------------------- -------------------------------------------------L SASSLLPKLLPALHCLAS-------------------------------- -------------------------------------------------- -------------------------------------LQA---------- -----------------------------------------------IFW MCTDHLGDLALL-------------------------------------- -------------------------------------LQTLNG------- ---------------IQ--------T---ETS------------------ --EDLLL-----LIKSWSPPPEK--------------------------- -------------------------------------------------- -------------SDAPLILQDAEGLRDVLL------------------- ------------------------T--------------------TLACR QGL--------QELITGSL----------------PRALSRLHEAASGVC PPSV------------------------------LVQVYTALGTCLRKMG -------------------------------------------------- ----------------NPQRAL-----LYLTAALKVGTTCALPLLE---- -------------------------------------------------- ---------------------------ASRIYRQLGDT----------AA ELESLELLVEALSAT----HSxxxSST---------------------LK FH----------------------------------IEVEL--------- -------------------------------------------------- -----------------LLPKPDPASPLHCGT------------------ -------------------------------------------------- -QSQAKRLL-----------------------------------ASRCLQ T------------------------------------------------- -------------------------------------------------- -----GRAED----------AAEHY------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ----------------------------------------LDL------- -------------------------------------------------- -------------------------------------------------- ---------------LAMLL-GSS-------------------------- -------------------------------------------------- -------------------------xPR---------------------- -------------------------------------------------- -----------------------------------F------S------- -----LPTSSP-GPCIPELCLEAAAALIQASRAPDA-------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ----------------------------------------LTVCE----- -------------------------------------------------- -------------------------------------------------- -------ELLSRISSL-----IPKT-SLW--------------------- ------ENARx--------------------------------------- -------------------------------------------------- -------------------------------------RT----------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- K------------------------------------------------- -----------------------------------------ELPY----- ---------CPIWISA---------------------------------- -------------------------------------------------- -------------------------------------------------- ----THLLQGQAWSQL--KARKEALSEFSQCLELLFRA------------ ----------------------------xxx-DK---------------E Qx--------------------------------------------xx-- --------S----------xxxxxxx------------------------ ------------xxV------------------A---------------- -----------------------LKQL----------------------- -------------------------------------------------- ----QVAALLSRGLEWIAS------------------------------- ---------------------------GQDTKALSDFLLSV--------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- --QICP-------------------------------------------- --------------------GNRDGSFY---------------------- -----------------------------LLQTLKRL------------- -------------------------------------------------- --ERRNEAAAF---------------------W----------------- -------R--EAQN-----QP-L----xxEAT----------W------- ------S-----------------------------------------LP LYLETC-------------------------------------------- -------------------------------------------LSWIHPP NCEALLKE----------------------------------------FG TSL----------------------------------------------- ---------------------------------x---------------- -------- >ENSMUGP00000023727 -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ----------M-----------SxxV------------------------ ----------xxxxxx---xx----------------------------- -SS-------------NLDLWREKNDGLVGQARQLx-KD----------- -------------------------------------------------- ------------xRSS---------------------------------- ----LRRQ----------------------------------------QL AQD---------------------------------------------TL EGFGELLLTL---------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ---------------------Q---------------------------- ------G------------------------------------------- ---LPAAVPALP-------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- --------------------------------------------LELTVI CNYIILRAS--LAQDFTEDLSQDVQRGLER-------------------- --------------VLETQN-QLG---PKxQPRLREL------------- --WDSV-------------------------------------------- -------------------------------------------------L SASSLLPELLPALHCLAS-------------------------------- -------------------------------------------------- -------------------------------------LQA---------- -----------------------------------------------VLW MSTDHLGDLTSL-------------------------------------- -------------------------------------LQTLNG------- ---------------SQ--------x------------------------ --EDLLV-----LLKSWNPPAQK--------------------------- -------------------------------------------------- -------------SLAPLMLQDAEGLRDVLL------------------- ------------------------T--------------------SFACR QGL--------QELVTGSL----------------SRAQRSLHEAASGVC PPSV------------------------------LVQVYTALGTCLRQMG -------------------------------------------------- ----------------NPQRAL-----LYLTEALKVGVACALPLLE---- -------------------------------------------------- ---------------------------ASRVYRQLGDT----------AA ELDSLGLLVEALSAT----HS---xET---------------------LK LF----------------------------------IEVEL--------- -------------------------------------------------- -----------------LLPQPDPASPLYCGT------------------ -------------------------------------------------- -QSQAKHLL-----------------------------------ASRCLQ T------------------------------------------------- -------------------------------------------------- -----GRAAD----------AAEHY------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ----------------------------------------LDL------- -------------------------------------------------- -------------------------------------------------- ---------------LAMLL-GSS-------------------------- -------------------------------------------------- -------------------------xPR---------------------- -------------------------------------------------- -----------------------------------L------S------- -----PPTSSP-GSCLPELYLEAAAALIQAGRALDA-------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ----------------------------------------LTVCE----- -------------------------------------------------- -------------------------------------------------- -------ELLSRTSSL-----LPKTSSLW--------------------- ------ENARx--------------------------------------- -------------------------------------------------- -------------------------------------RT----------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- K------------------------------------------------- -----------------------------------------ELPY----- ---------CPIWVSA---------------------------------- -------------------------------------------------- -------------------------------------------------- ----THLLQGQAWSKL--KAQKEALSDFSQCLELVFRV------------ ----------------------------xxx-DK---------------- x----------------------------------------------x-- --------S----------xxxxxxx------------------------ ------------xxV------------------A---------------- -----------------------LQQL----------------------- -------------------------------------------------- ----QVTALISRGLEWVAS------------------------------- ---------------------------GQDNKALRDFLLSV--------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- --QICP-------------------------------------------- --------------------GNRDGSFY---------------------- -----------------------------LLQTLKRL------------- -------------------------------------------------- --DRKNEAIAF---------------------W----------------- -------R--EAQT-----QQ-P----xxEAA----------W------- ------S-----------------------------------------LP LYLETC-------------------------------------------- -------------------------------------------LSWIRPP NCEVFLEE----------------------------------------FG TAL----------------------------------------------- ---------------------------xxSCD-L---------------- -------- >ENSJJAP00000001163 -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ----------M-----------SxxT------------------------ ----------xxxxxx---xx----------------------------- -AS-------------CLDLWRNKNDQLVQRAKQVx-LD----------- -------------------------------------------------- ------------xRVS---------------------------------- ----LRRQ----------------------------------------QL AQD---------------------------------------------TL EGLRKLLHIL---------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ---------------------Q---------------------------- ------G------------------------------------------- ---LPAAVPALL-------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- --------------------------------------------LELTVT CNFIILRTN--LTRSFTEDQIQDIKWGLER-------------------- --------------VLETQK-QKG---PKxGQGLREL------------- --WVSV-------------------------------------------- -------------------------------------------------L HASSLAPELLPVLHNLAS-------------------------------- -------------------------------------------------- -------------------------------------LQA---------- -----------------------------------------------ALW LSTDHLEDLAFL-------------------------------------- -------------------------------------LKTLNG------- ---------------HQ--------T---GAS------------------ --EDLLL-----LLKSWSPPAEE--------------------------- -------------------------------------------------- -------------SDAPLTLQNAQTMRDVLL------------------- ------------------------T--------------------AFAYR QGL--------QELITESL----------------PSALKSLHEAASGLC PRPL------------------------------LVQVYTAVGFCLRKMG -------------------------------------------------- ----------------NPQRAL-----LYLTEALKRGPTWGPPLLE---- -------------------------------------------------- ---------------------------ASRVYRQLGDV----------AA ELESLELLVEALSTT----PS---xEA---------------------PQ LL----------------------------------IEVEL--------- -------------------------------------------------- -----------------LLPQPDPASPLHCGT------------------ -------------------------------------------------- -QSQAKHLL-----------------------------------ASRCLQ T------------------------------------------------- -------------------------------------------------- -----GRAED----------ASEHY------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ----------------------------------------LDL------- -------------------------------------------------- -------------------------------------------------- ---------------LALLL-DGS-------------------------- -------------------------------------------------- -------------------------xPR---------------------- -------------------------------------------------- -----------------------------------F------T------- -----PSPGSS-GPCVPEMFLEAAAALIQAGRAQDA-------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ----------------------------------------LTVCQ----- -------------------------------------------------- -------------------------------------------------- -------ELLSRTSSL-----LPKMSWLW--------------------- ------EDARx--------------------------------------- -------------------------------------------------- -------------------------------------RT----------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- K------------------------------------------------- -----------------------------------------VLPY----- ---------CPLWVSA---------------------------------- -------------------------------------------------- -------------------------------------------------- ----THLLQGQAWVQL--KAQKEALSEFSQCLELLFRA------------ ----------------------------xxx-DK---------------E Q----------------------------------------------x-- --------S----------xxxxxxx------------------------ ------------xxV------------------V---------------- -----------------------LQQL----------------------- -------------------------------------------------- ----RAAALISRGLEWVAS------------------------------- ---------------------------GQDTRALKDFLLSV--------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- --QICP-------------------------------------------- --------------------GHRSGSLY---------------------- -----------------------------LLQTLKRL------------- -------------------------------------------------- --DRMNEATAF---------------------W----------------- -------Q--EAQT-----QL-P----xxQAT----------W------- ------S-----------------------------------------LP LYLETY-------------------------------------------- -------------------------------------------LNWIHSS DCETLLEE----------------------------------------FQ TSV----------------------------------------------- ---------------------------xxPHD-L---------------- -------- >ENSNGAP00000001208 -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ----------M-----------SxxI------------------------ ----------xxxxxx---xx----------------------------- -AS-------------CLDLWRQKNDRLVHQARQLx-RD----------- -------------------------------------------------- ------------xSPS---------------------------------- ----LRRQ----------------------------------------RL AQD---------------------------------------------IL EKFRGLLHTL---------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ---------------------Q---------------------------- ------G------------------------------------------- ---LPAAVPALP-------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- --------------------------------------------LELTVT CNFIILRAS--LAQGFPEDLTQDIQRSLER-------------------- --------------VLETQN-QLG---PKxEQGLKEL------------- --WNSV-------------------------------------------- -------------------------------------------------L HSSSLLPELLPALHCLAS-------------------------------- -------------------------------------------------- -------------------------------------LQA---------- -----------------------------------------------ALW LSTDHLGDLALL-------------------------------------- -------------------------------------LQTLNG------- ---------------SQ--------T---EAS------------------ --ENLLL-----LLKSWSSPAEM--------------------------- -------------------------------------------------- -------------SDAPLTLQNASALRDVVL------------------- ------------------------T--------------------AFAYR QGF--------QELITGNL----------------PSALSSLHEAASGLC PQPM------------------------------LVQVYTALGTCLRKMG -------------------------------------------------- ----------------SPQKAL-----LYLTAALKVGTTWAPPLLE---- -------------------------------------------------- ---------------------------ASRLYRQLGDT----------SA ELESLKLLAEALSAT----HN---xEA---------------------PK LL----------------------------------IEVDL--------- -------------------------------------------------- -----------------LLPQPDPASPLHCGT------------------ -------------------------------------------------- -QSQAKYLL-----------------------------------ASRCLQ A------------------------------------------------- -------------------------------------------------- -----GRAEE----------AAEHY------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ----------------------------------------LDL------- -------------------------------------------------- -------------------------------------------------- ---------------LALLL-DGS-------------------------- -------------------------------------------------- -------------------------xPR---------------------- -------------------------------------------------- -----------------------------------F------S------- -----PPPSPS-GPCMPELFLEAAAALIQAGRPQDA-------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ----------------------------------------LTVCE----- -------------------------------------------------- -------------------------------------------------- -------ELLSRTSSL-----LPKMSWLQ--------------------- ------ENVRx--------------------------------------- -------------------------------------------------- -------------------------------------GT----------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- R------------------------------------------------- -----------------------------------------KLPH----- ---------CPLWVSA---------------------------------- -------------------------------------------------- -------------------------------------------------- ----THLLQGQAWSQL--KAPKEALSEFSQCLELLFQA------------ ----------------------------xxx-DK---------------E Q----------------------------------------------x-- --------xx----xxxxxxx----------------------------- ------------xxV------------------A---------------- -----------------------LQQL----------------------- -------------------------------------------------- ----RVAALISRGLEWVSS------------------------------- ---------------------------SQDTKALNDFLLSV--------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- --QICP-------------------------------------------- --------------------GNRDGSVY---------------------- -----------------------------LLQTLKRL------------- -------------------------------------------------- --DRKNEATAF---------------------W----------------- -------R--EAQT-----HL-L----xxEAA----------W------- ------S-----------------------------------------VP LYLETY-------------------------------------------- -------------------------------------------LSWLHPP NCETLLEE----------------------------------------FQ TSL----------------------------------------------- ---------------------------xxSHD-L---------------- -------- >ENSPCIP00000029199 -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ----------M-----------xxxxxxxxxxxxxxxxxxxxxxxxxxxx xxxxxxxxxxxxxxxxxxxxx----x------------------------ -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- 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-------------------------------------LQG---------- -----------------------------------------------AMW LTDNRPGDLAIL-------------------------------------- -------------------------------------LCAMMN------- ---------------SQ--------Y---xxxxxxxxx------------ xxEDLLS-----LLSVWDPCFEE--------------------------- -------------------------------------------------- -------------LDAPLTLQDARSLRDVLL------------------- ------------------------T--------------------TAAFH QGL--------QELHVGNL----------------PLALSSLQKAAFSLC PRSV------------------------------LTQVHTALGACLRKMG -------------------------------------------------- ----------------HPQRAL-----LHLLEALKADPGQGPPLLE---- -------------------------------------------------- ---------------------------AARLYRQLGHT----------AS ELESLKLLVEALSIP----HS---PRT---------------------PL FS----------------------------------IGVEL--------- -------------------------------------------------- -----------------LITPPSPASSLYCGT------------------ -------------------------------------------------- -QSQVKHML-----------------------------------ASRCLQ T------------------------------------------------- -------------------------------------------------- -----GRNEE----------AVEQY------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ----------------------------------------LDL------- -------------------------------------------------- -------------------------------------------------- ---------------LALLL-DGSx------------------------- ---------------------------------------xxGxxxxxxxx x---------------------xxxxxx---------------------- -------------------------------------------------- -------------------------------------------------- ---------------VPEVFLETAAALIIVGRFQDS-------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ----------------------------------------LTVCE----- -------------------------------------------------- -------------------------------------------------- -------ELLSRISLL-----VPQ--xxxx----xxxxxxxxxxxxxxxx xxxxxxxxx----------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- --------------------------------------------F----- ---------CLLWASA---------------------------------- -------------------------------------------------- -------------------------------------------------- ----AHLLQGQAHSGL--GARKEALEEFSRCLELLFRV------------ ----------------------------xxx-DRx-------------xx x----------------------------------------------xx- -------xx----------xxxxxxx------------------------ ------------GxV-ISSxxxxxxxxxxxxxxV---------------- -----------------------LQRL----------------------- -------------------------------------------------- ----KAVTLISRGLEWVAE------------------------------- ---------------------------GQDARALQDFLLGV--------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- --QVCP-------------------------------------------- --------------------GDRNASLH---------------------- -----------------------------LLRVLWRL------------- -------------------------------------------------- --ERREEAVAT---------------------Y----------------- -------QRLEAEA-----DQ-E----QGDSE----------G------- ------L-----------------------------------------LP QYLESC-------------------------------------------- -------------------------------------------MNRIQIT EQESLLQE----------------------------------------LR KSL----------------------------------------------- ---------------------------xxPTC-P---------------- -------- >ENSMODP00000009639 -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ----------x--------------------------------------- -------------------xx----xxxxxx------------------x xPG-------------CLGLWKAENDRLVRQWRVxx-xD----------- -------------------------------------------------- ------------xGQP---------------------------------- ----x-xx----------------------------------------xx xxx---------------------------------------------VL EEFRGLLHKL---------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ---------------------Q---------------------------- ------G------------------------------------------- ---LPSALSVLP-------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- --------------------------------------------LELTVL GNSLTLGVG--LVQGFMKDHVLNIQQSLER-------------------- --------------VLNAQG-VPL---Pxx----GDL------------- --WGAI-------------------------------------------- -------------------------------------------------F QSPFIPSEMLPPLHHLVG-------------------------------- -------------------------------------------------- -------------------------------------LQG---------- -----------------------------------------------ALW LTDNHPGDLIIL-------------------------------------- -------------------------------------LRTVMS------- ---------------SQ--------C---xxxxxxxxx------------ xxEDLLS-----LLHAWDPPIEV--------------------------- -------------------------------------------------- -------------PDAPLALQDARSLKDVLL------------------- ------------------------T--------------------TAAFH QGL--------HELHMENL----------------SLALSSLQKAAFSPC PRPV------------------------------LVLVHTALGACLRKMG -------------------------------------------------- ----------------HPQRAL-----LHLLEALKAGLTPGPPLLE---- -------------------------------------------------- ---------------------------AARLYRQLGHT----------TA ELDSLKLLVEALSIP----HS---SRP---------------------PL FP----------------------------------LGVEL--------- -------------------------------------------------- -----------------LITALRPASSLSCGT------------------ -------------------------------------------------- -QSQAKHLL-----------------------------------ASRCLQ T------------------------------------------------- -------------------------------------------------- -----GRGEE----------AVEQY------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ----------------------------------------LDL------- -------------------------------------------------- -------------------------------------------------- ---------------LALLL-DGSx------------------------- ---------------------------------------xxGxxxxxxxx x---------------------xxxxxx---------------------- -------------------------------------------------- -------------------------------------------------- ---------------VPDVFLETATALILVARFQDS-------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ----------------------------------------LTVCE----- -------------------------------------------------- -------------------------------------------------- -------ELLSRIAPL-----VPQ--xxxx----xxxxxxxxxxxxxxxx xxxxxxxxx----------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- --------------------------------------------F----- ---------YLLWASA---------------------------------- -------------------------------------------------- -------------------------------------------------- ----AHLLQGQAHSGL--GARREALEEFSRCLELLFRV------------ ----------------------------xxx-DRx-------------xx x----------------------------------------------xx- -------xx----------xxxxxxx------------------------ ------------RxVIISSxxxxxxxxxxxxxxV---------------- -----------------------LQKL----------------------- -------------------------------------------------- ----KVVALISRGLEWVAE------------------------------- ---------------------------GRDARALQDFLLAV--------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- --QLCP-------------------------------------------- --------------------GDRRASLH---------------------- -----------------------------LLYVLWRL------------- -------------------------------------------------- --ERREEAAAI---------------------C----------------- -------QRLEAEA-----DQ-Y----QDNSE----------G------- ------L-----------------------------------------LP LYLESC-------------------------------------------- -------------------------------------------VNRIPIT EQESLLRE----------------------------------------LQ KSL----------------------------------------------- ---------------------------xxPTC-S---------------- -------- >ENSGAGP00000011282 -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ----------x--------------------------------------- -------------------------------------------------- -------------------------xxxxxx------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- RAFDSLLRKI---------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- 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-------------------------------------------------- -------------DTSPLVVQSTKDLKEILW------------------- ------------------------T--------------------SAAFL QGL--------QGLEAGNL----------------PTALSLLQAAASGFC SKRV------------------------------LAQIYTSIGCCTQQMG -------------------------------------------------- ----------------KPQTAL-----QHLKRALQVDFQCLSALSQ---- -------------------------------------------------- ---------------------------AALVYRQLGET----------DA ELEALALLYKALETPxQ-xTV---SID---------------------PC FL----------------------------------IRTEL--------- -------------------------------------------------- -----------------LVHTPALASLFSRSH------------------ -------------------------------------------------- -PSEVKYLL-----------------------------------AQRCLQ A------------------------------------------------- -------------------------------------------------- -----GRVAE----------AVEHY------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ----------------------------------------LDL------- -------------------------------------------------- -------------------------------------------------- ---------------LALLQ-EGP-------------------------- -------------------------------------------------- -------------------------QHQ---------------------- -------------------------------------------------- -----------------------------------x------P------- -----LHGRSA-LPRIPEVFLEAASALEQLGRHQDA-------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ----------------------------------------IAVCE----- -------------------------------------------------- -------------------------------------------------- -------EIISRTDDL-----IPETLRIEx-------------------- -------------------------------------------------- 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-------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- --QVCP-------------------------------------------- --------------------GDPAATSH---------------------- -----------------------------LLRTLWKL------------- -------------------------------------------------- --NRRQEAAAL---------------------W----------------- -------QKLHADA-----PP-x----xxxxx----------xxxx---- ------P-----------------------------------------YP LYLVSC-------------------------------------------- -------------------------------------------LKQVNLP HDESLARS----------------------------------------LQ DYLxxx-------------------------------------------- ---------------------------xxx---P---------------- -------- >ENSCABP00000009145 -------------------------------------------------- -------------------------------------------------- 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-------------------------------------------------- -------------------------------------------------- -------------------------------------------------- --------------------------------------------LELTVL YNSLLFAVS--ESDGLVEGEAERINHGLIR-------------------- --------------VLEACG-VSG---QDx--STEEL------------- --WQKV-------------------------------------------- -------------------------------------------------L QDVT-TEELCAPLHRLGA-------------------------------- -------------------------------------------------- -------------------------------------LQG---------- -----------------------------------------------AVW LAANCLGSVTGL-------------------------------------- -------------------------------------FRLLSD------- ---------------TKxx-x----xxxxGGE------------------ --NELLV-----LLKAWSVPVEG--------------------------- -------------------------------------------------- -------------DTSPLVVQSTKDLKEILW------------------- ------------------------T--------------------SAAFL QGL--------QGLEAGNL----------------PTALSLLQAAASGFC SKRV------------------------------LAQIYTSIGCCTQQMG -------------------------------------------------- ----------------KPQTAL-----QHLKRALQVDFQCLSALSQ---- -------------------------------------------------- ---------------------------AALVYRQLGET----------DA ELEALALLYKALETPxQ-xAV---SID---------------------PC FL----------------------------------IRTEL--------- -------------------------------------------------- -----------------LVHTPALASLFSRSH------------------ -------------------------------------------------- -PSEVKYLL-----------------------------------AQRCLQ A------------------------------------------------- -------------------------------------------------- -----GRVAE----------AVEHY------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ----------------------------------------LDL------- 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-------------------------------------------------- -------------------------------------------------- --QVCP-------------------------------------------- --------------------GDPAATSH---------------------- -----------------------------LLRALWKL------------- -------------------------------------------------- --NRRQEAAAL---------------------W----------------- -------QKLHADA-----AP-x----xxxxx----------xxxx---- ------P-----------------------------------------YP LYLVSC-------------------------------------------- -------------------------------------------LKQVSLP HDESLAGS----------------------------------------LQ DYLxxx-------------------------------------------- ---------------------------xxx---P---------------- -------- >ENSCPBP00000025201 -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- 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--------------------------------------------LELTVL YNSLLFAVS--ESDGLVEGEAERINHGLIR-------------------- --------------VLEACG-VSG---QDx--STEEL------------- --WQKV-------------------------------------------- -------------------------------------------------L QDVT-TEELCAPLHRLGA-------------------------------- -------------------------------------------------- -------------------------------------LQG---------- -----------------------------------------------AVW LAANCLGSVTGL-------------------------------------- -------------------------------------FRLLSD------- ---------------TKxx-x----xxxxGGE------------------ --NELLA-----LLKAWSVPVEG--------------------------- -------------------------------------------------- -------------DTSPLVVQSTKDLKEILW------------------- ------------------------T--------------------SAAFL QGL--------QGLEAGNL----------------PTALSLLQAAASGFC SKRV------------------------------LAQIYTCIGCCTQQMG -------------------------------------------------- ----------------KPQTAL-----QHLKRALQVDFQCLSALSQ---- -------------------------------------------------- ---------------------------AALVYRQLGET----------DA ELEALALLYKALETPxQ-xAV---SID---------------------PC FL----------------------------------IRTEL--------- -------------------------------------------------- -----------------LVHTPALASLFSRSH------------------ -------------------------------------------------- -PSEVKYLL-----------------------------------AQRCLQ A------------------------------------------------- -------------------------------------------------- -----GRVGE----------AVEHY------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ----------------------------------------LDL------- -------------------------------------------------- -------------------------------------------------- ---------------LALLQ-EGP-------------------------- 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-----------------------------------------ESLR----- ---------CIVWRAA---------------------------------- -------------------------------------------------- -------------------------------------------------- ----AYLHQGRAWARL--GESKEAITRFTRCLNVLLRVx----------- xxxxxx------------xxxxxxxxxxxxx-xx---------------- -------------------------------------------------- -------------------------------------------------- ---------------------------------V---------------- -----------------------LQKI----------------------- -------------------------------------------------- ----RLLALLGRGSQFQEL------------------------------- ---------------------------GRDKEALMNFQHSL--------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- --QVCP-------------------------------------------- --------------------GDPAATSH---------------------- -----------------------------LLRALWKL------------- -------------------------------------------------- --NRRQEAAAL---------------------W----------------- -------QKLHADA-----AP-x----xxxxx----------xxxx---- ------P-----------------------------------------YP LYLVSC-------------------------------------------- -------------------------------------------LKQVNLP HDESLARS----------------------------------------LQ DYLxxx-------------------------------------------- ---------------------------xxx---P---------------- -------- >ENSCPRP00005022181 -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ----------x-----------xxx------------------------- -------------------------------------------------- --------------------WAGDCAQLVRSWRxxx-------------- 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--WQKV-------------------------------------------- -------------------------------------------------L QEVP-AEELRAPLHQLGV-------------------------------- -------------------------------------------------- -------------------------------------LQG---------- -----------------------------------------------VLW LAANRLGSITGL-------------------------------------- -------------------------------------LRLLSG------- ---------------AKxx-xxxxxP---GGE------------------ --NELLA-----LLRAWQVPADG--------------------------- -------------------------------------------------- -------------GTSPLVVQSARDVREILW------------------- ------------------------T--------------------AAAFL QGF--------QELEAGNL----------------PAALSLLQLAATGFC SKRV------------------------------LAQIYICLGCCTRQMG -------------------------------------------------- ----------------KPQTAL-----QHLKQALQLDFQCLTALSQ---- -------------------------------------------------- ---------------------------AAMVYHQLGEM----------DA ELEALALL------------------------------------------ -------------------------------------------------- -------------------------------------------------- -------------------------------xxx-----xxxxxxxxxxx xxxxxxxxxxxxxxxx---------------------xxxxx-----xxx xPSEVKYLL-----------------------------------AQRCLQ A------------------------------------------------- -------------------------------------------------- -----GRTAE----------AGEHY------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ----------------------------------------LDL------- -------------------------------------------------- -------------------------------------------------- ---------------LAVLQ-EGP-------------------------- -------------------------------------------------- -------------------------RHQ---------------------- -------------------------------------------------- -----------------------------------x------P------- -----LHSQSA-LPRIPEVFLEAACALEQLGRHRDT-------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ----------------------------------------IAVCE----- -------------------------------------------------- -------------------------------------------------- -------EVVSRTSDL-----TPEMLRIDxxxxxxxxxxx---------- -----xx-------xxx--------------------------------- -------------------------------------------------- --xxxxxxx-------------------------ILxQK----------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- K------------------------------------------------- -----------------------------------------ESLR----- ---------CILWRAA---------------------------------- -------------------------------------------------- -------------------------------------------------- ----AYLHQGRAWAGL--ADSKEAITQFTRCLNDLLRVx----------- xxxxxx------------xxxxxxxxxxxxx-xx---------------- -------------------------------------------------- -------------------------------------------------- ---------------------------------V---------------- -----------------------LQKI----------------------- -------------------------------------------------- ----RLLALVGRGTQFLEL------------------------------- ---------------------------GRDRDALMNFQYAL--------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- --QVSP-------------------------------------------- --------------------GDLAAASH---------------------- -----------------------------LLQTLWKL------------- -------------------------------------------------- --DRRQEAAAL---------------------W----------------- -------QKLQADS-----GQ-x----xxxxx----------xxxx---- ------S-----------------------------------------FP LYLTLC-------------------------------------------- -------------------------------------------PQPTNLL LDGSLARS----------------------------------------LQ DYLxxx-------------------------------------------- ---------------------------xxx---P---------------- -------- >ENSNPEP00000006915 -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- 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LYLVSC-------------------------------------------- -------------------------------------------LKQATFP QNESLARD----------------------------------------LQ DYLxx--------------------------------------------- ------------------------------xx-x---------------- -------- >ENSARWP00000024279 -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ----------x-----------xxxx------------------------ -------------------------xxxxxxx------------------ --G-------------CLRAWAAESEALAGRWRxxx-------------- --------------------------xxx--------------------- --------------PG---------------------------------- ----xxxx------------------------------------------ ARQ---------------------------------------------QR GAFGELLLRM---------------------------------------- -------------------------------------------------- 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LATNRLGSITSL-------------------------------------- -------------------------------------FRLLSN------- ---------------AExx-xxxxxS---GGK------------------ --NELLS-----LLKAWRVPAEG--------------------------- -------------------------------------------------- -------------DSVSL-VQSAEDLKEILC------------------- ------------------------T--------------------AAAFL QGL--------QELEAGNL----------------PAALSLLQEAAGGFC SKRV------------------------------LAQIYTCLSCCTRQMG -------------------------------------------------- ----------------KPQTAL-----QHLKRALQVDFQCLPALSH---- -------------------------------------------------- ---------------------------AAAVYHELGET----------DA ELQALAVLYEALERNxP-xAA---STT---------------------PY CL----------------------------------IQTEH--------- -------------------------------------------------- -----------------LVHTPALASLFRHRH------------------ -------------------------------------------------- -PSEVKYLL-----------------------------------AQRCLQ 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-------EVIKRIASI-----VPEKLTIA--------------------- ------VPL----------------------------------------- -------------------------------------------------- -------------------------------xxx---------------- --xxx----xxxxxxxxxx------------------------------- ------------------------------xxxxxxxxxxxxx------- -----------------------------------------------xxx x------------------------------------------x------ -------------------------------xx--------EKLN----- ---------CILWTAA---------------------------------- -------------------------------------------------- -------------------------------------------------- ----AYFYQGWAFTEL--KDTKESITHLSRCINLLLTVxxx--------- --------------------------------QS---------------D -------------------------------------------------- --------------------------------xx---------------- xxxxxxxxxxxxEAV-----------------xL---------------- -----------------------LHRL----------------------- -------------------------------------------------- ----KGLAFVRRGISFMER------------------------------- ---------------------------GQEKEALLNFQLSQ--------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- --QSFP-------------------------------------------- --------------------ESVDGAFW---------------------- -----------------------------LLEALWRF------------- -------------------------------------------------- --GRKDEAVSY---------------------W----------------- -------QKLQESx-----xS-x-------xx------------------ -----xx---------------------------------xxxxx-xxxx xxxx---------------------------------------------- --------------------------------------------xxxSTS DLETLNKK----------------------------------------IE EY--xx-------------------------------------------- -----------------------------xxx-x---------------- -------- >ENSORLP00020010812 xxx-------------------xx-------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- --------xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx xxxxxxxxxxx-----------x--------------------------- -------------------------------------------------x xQS-------------LFNYWTQENNELVRNFKxxx-xx----------- ----------xxxxxxx--------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------T SGFQKLLRKI---------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ---------------------Q---------------------------- ------G------------------------------------------- ---VPPETDHAQ-------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- --------------------------------------------LELSVV YNACICLIS--QSQxxxxxx--LLKQATER-------------------- --------------ILQMKW-ENL---CQx--DAPIL------------- --WITA-------------------------------------------- -------------------------------------------------I RSVE-NxALHPFLLLLPC-------------------------------- -------------------------------------------------- -------------------------------------LQW---------- -----------------------------------------------AIW LATCQLKPIKDFx------------------------------------- -----------------------------------x-------------- -------------------------------------------------- ------------------------xxxxxxxxxx---------------- -------------------------------------------------- xxxxxxxxxxxxxKKVPLLVMDPQRFTELLQ------------------- ------------------------I--------------------CRVIV QSA--------EQMNEGRS----------------SEALPLLQAASKLPA PKTL------------------------------VAYTHLLSGSCLAHMN -------------------------------------------------- ----------------FPQMAL-----HCYKKALETDAQCVYALHQ---- -------------------------------------------------- ---------------------------STVVYSELGNT----------QA EIQALHIMHSTLLLPxP-xEP---STA---------------------GV QL----------------------------------LSPSL--------- -------------------------------------------------- -----------------LLGSQSLKDLLSVPS------------------ -------------------------------------------------- -ALSVLHRL-----------------------------------ALKCIL S------------------------------------------------- -------------------------------------------------- -----GRVSE----------GVKHY------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ----------------------------------------LDL------- -------------------------------------------------- -------------------------------------------------- ---------------LATLH-SED-------------------------- -------------------------------------------------- -------------------------HHR---------------------- -------------------------------------------------- -----------------------------------x-----xV------- -----HSEFST-LPRLPKLYLEAAVALLIAQRPADS-------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ----------------------------------------MALCM----- -------------------------------------------------- -------------------------------------------------- -------EVIDSTLEL-----LPEAVVIE--------------------- ------EPEExxxx------------------------------------ -------------------------------------------------- ----------------------------------xxxxx----------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- E------------------------------------------------- -----------------------------------------DRVA----- ---------ALLWAAA---------------------------------- -------------------------------------------------- -------------------------------------------------- ----AYLLQGQCYSQL--KDWKQAVTHYTRCVNMLVKVxxx--------- --------------------------------RR---------------x xxxxxxxxxx-----------------xxx-------------------- ----------------------xx-------------------------- ------------ANL-----------------xI---------------- -----------------------LQRL----------------------- -------------------------------------------------- ----KGLSLAGRGISFSQM------------------------------- ---------------------------DHLKEALRDLQLSL--------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- --QALP-------------------------------------------- --------------------EGIGAGLW---------------------- -----------------------------CGEVLWRL------------- -------------------------------------------------- --DRKREAAAR---------------------W----------------- -------EATWSLP-----TQ-x-------xx------------------ -----xS-----------------------------------------FP LYAQEx-------------------------------------------- -------------------------------------------xxx-PLL DSTELRHR----------------------------------------TQ EL------------------------------------------------ ------------------------------xx-x---------------- -------- >ENSORLP00015000584 -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ----------x-----------x--------------------------- -------------------------------------------------x xxS-------------LFDYWTEENNELVRNCK--x-xx----------- ----------xxxxxxx--------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------T SGFQKLLRKI---------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ---------------------Q---------------------------- ------G------------------------------------------- ---VPPETDHAQ-------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- --------------------------------------------LELSVV YNACICLIS--QSQxxxxxx--LLKQATER-------------------- --------------ILQMKG-ENL---CQx--DAPIL------------- --WITA-------------------------------------------- -------------------------------------------------I RSVE-NTALHPFLLLLPC-------------------------------- -------------------------------------------------- -------------------------------------LQW---------- -----------------------------------------------AIW LATCQLKPIKDFx------------------------------------- -----------------------------------x-------------- -------------------------------------------------- ------------------------xxxxxxxxxx---------------- -------------------------------------------------- xxxxxxxx--xxxTKVPLLVMDPKRFTELLQ------------------- ------------------------I--------------------CRVIV QSA--------EQMNEGRS----------------SEALPLLQAASKLPA PKNL------------------------------VAYTHLLSGSCLAHMN -------------------------------------------------- ----------------CPQMAL-----HCYKKALETDAQCVYALHQ---- -------------------------------------------------- ---------------------------STLIYSELGNT----------QA EIQALHIMHSTLLLPxP-xEP---STA---------------------GV QL----------------------------------LSPSL--------- -------------------------------------------------- -----------------LLGSQSLKNLLSVPS------------------ -------------------------------------------------- -ALSVLHRL-----------------------------------ALKCIL S------------------------------------------------- -------------------------------------------------- -----GRVSE----------GVKHY------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ----------------------------------------LDL------- -------------------------------------------------- -------------------------------------------------- ---------------LATLH-SED-------------------------- -------------------------------------------------- -------------------------HHR---------------------- -------------------------------------------------- -----------------------------------x-----xV------- -----HSEFST-LPRLPKLYLEAAVALLMAQRPADS-------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ----------------------------------------MALCM----- -------------------------------------------------- -------------------------------------------------- -------EVIDSTLEL-----LPETVVIE--------------------- ------EPEEGxxx------------------------------------ -------------------------------------------------- ----------------------------------xxxxx----------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- E------------------------------------------------- -----------------------------------------DRVA----- ---------ALLWGAA---------------------------------- -------------------------------------------------- -------------------------------------------------- ----AYLLQGQCYSQL--KDWKQAVTHYTRCVNILVKVxxx--------- --------------------------------RR---------------x xxxxxxxxxx-----------------xxx-------------------- ----------------------xx-------------------------- ------------ANL-----------------xI---------------- -----------------------LQRL----------------------- -------------------------------------------------- ----KGLSLAGRGISFSQM------------------------------- ---------------------------DHLKEALRDLQLSI--------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- --QALP-------------------------------------------- --------------------EGIGAGLW---------------------- -----------------------------CGEVLWRL------------- -------------------------------------------------- --DRKREAAAR---------------------W----------------- -------EATWSLP-----TQ-x-------xx------------------ -----xS-----------------------------------------FP LYAQEx-------------------------------------------- -------------------------------------------xxx-PLL DSTELRHR----------------------------------------IQ EL------------------------------------------------ ------------------------------xx-x---------------- -------- >ENSOMEP00000023967 -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ----------x-----------x--------------------------- -------------------------------------------------x xxS-------------LFDYWTQENNDLVKICKxxx-xx----------- ----------xxxxxxx--------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------T SDFQKLLRKI---------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ---------------------Q---------------------------- ------G------------------------------------------- ---VPPETDHAQ-------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- --------------------------------------------LELSVV YNACICFIA--QSQxxxxxx--LLKQAAER-------------------- --------------TLQMKG-ESL---CQx--DAPIV------------- --WMTA-------------------------------------------- -------------------------------------------------V KSVK-NTALHRFLLFLPC-------------------------------- -------------------------------------------------- -------------------------------------LQW---------- -----------------------------------------------AIW LATCQLKPIEDFx------------------------------------- -----------------------------------x-------------- -------------------------------------------------- ------------------------xxxxxxxxxx---------------- -------------------------------------------------- xxxxxxxxxxxxxRIVPTLVMDPKRLVELLQ------------------- ------------------------I--------------------CSVIA QGA--------EKLNEGRG----------------SEALPRLQAASKLPA PKAL------------------------------VAYTHLLSGSCLTHMN -------------------------------------------------- ----------------CPQMAL-----QCYKKALETDAQCVYALHQ---- -------------------------------------------------- ---------------------------SSRIYSELGNA----------QA EIQALHILHLTLLLPxS-xEP---STA---------------------GV HL----------------------------------LSPFL--------- -------------------------------------------------- -----------------LLASQSLKNLLSVPS------------------ -------------------------------------------------- -PLSVLHKL-----------------------------------ALKCIL N------------------------------------------------- -------------------------------------------------- -----IRVPE----------GVKHY------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ----------------------------------------LDL------- -------------------------------------------------- -------------------------------------------------- ---------------LAALH-SED-------------------------- -------------------------------------------------- -------------------------HHG---------------------- -------------------------------------------------- -----------------------------------x-----xV------- -----HSEFST-LPRLPKLYLEAAVALLMAQRPADS-------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ----------------------------------------MALCT----- -------------------------------------------------- -------------------------------------------------- -------EVIETTLEL-----LPEKLVIE--------------------- ------EPEEGxxxx----------------------------------- -------------------------------------------------- -------------------------------xxxxxxxx----------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- E------------------------------------------------- -----------------------------------------GTLA----- ---------VFLWAAA---------------------------------- -------------------------------------------------- -------------------------------------------------- ----AYLLQGHCYSQL--KDWKQAVTHYTRCVNMLVKVxxx--------- --------------------------------RK---------------D xxxxxxxxxx-----------------xxx-------------------- ----------------------xx-------------------------- ------------ADL-----------------xI---------------- -----------------------LQRL----------------------- -------------------------------------------------- ----KGLSLAGRGISFSQM------------------------------- ---------------------------DHLKEALRDLQLSL--------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- --QAVP-------------------------------------------- --------------------EGIGAGLW---------------------- -----------------------------CGEVLWRL------------- -------------------------------------------------- --DRKREAAARx-----------xxxxxxxxx------------------ -------------------------------------------------- -------------------------------------------------P LYAQEx-------------------------------------------- -------------------------------------------xxx-PSL DPTELRHR----------------------------------------IQ KL------------------------------------------------ ------------------------------xx-x---------------- -------- >ENSNBRP00000006174 -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ----------x-----------x--------------------------- -------------------------------------------------x xxS-------------LLEKWSQENNELVNKCK----------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ------------x-----------------------------xx------ --------------------------xxxxxxx----------------- -------------------------------------------------- -------------------------------------------------- ------------------------------------------xxLELAVV YNTCVCFTA--QSQxxxxxx--LLKEATER-------------------- --------------VLQVTG-NNA---DTx--DPLVL------------- --WRAG-------------------------------------------- -------------------------------------------------L KSAG-NTALHPHVLYLLC-------------------------------- -------------------------------------------------- -------------------------------------LQW---------- -----------------------------------------------ALW LAKCQLENIWEL-------------------------------------- ------------------------------------xxx----------- -------------------------------------------------- -------------------------xxxxxxxxx---------------- -------------------------------------------------- xxxxxxxxxxxxxSKSPLLVMELKRLTELLQ------------------- ------------------------I--------------------CTSIA QGA--------EKLNEGRS----------------SEALSDLQAASALSA TRAL------------------------------VAYTHLLSGSCLAHMN -------------------------------------------------- ----------------RPQMAL-----QCYKRALETDSRCVCALYR---- -------------------------------------------------- ---------------------------SMLIYRQLGNT----------QA EIQALRLLHSTLMLPxA-xEP---VLG---------------------GI HP----------------------------------LSPSL--------- -------------------------------------------------- -----------------LLSSHSLSRLLLVPS------------------ -------------------------------------------------- -ALSVLYSL-----------------------------------ALKCVL S------------------------------------------------- -------------------------------------------------- -----GRVTE----------GVEHY------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ----------------------------------------LDL------- -------------------------------------------------- -------------------------------------------------- ---------------LAALH-SED-------------------------- -------------------------------------------------- -------------------------QHA---------------------- -------------------------------------------------- -----------------------------------x-----xV------- -----DAEVSV-LPRMPELYLEAGAALLFTRRPADC-------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ----------------------------------------MALCN----- -------------------------------------------------- -------------------------------------------------- -------EVISTTLEL-----VPEKVVLE--------------------- ------EPDEGIxxx----------------------------------- -------------------------------------------------- -------------------------------xxxxxxxx----------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- E------------------------------------------------- -----------------------------------------DKVA----- ---------MLLWAAA---------------------------------- -------------------------------------------------- -------------------------------------------------- ----AYLLQGHCHAHL--KDWKQAVTHYTRCINLLVKVxxx--------- --------------------------------NR---------------x -----------------------------------------xxxxxxx-- --------A-------xx-xxxxx-------------------------- ------------KDL-----------------xA---------------- -----------------------LQRM----------------------- -------------------------------------------------- ----KGLSLAWRGISFTQM------------------------------- ---------------------------DQLREALRDLQLSL--------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- --QAFP-------------------------------------------- --------------------DYTGAGLW---------------------- -----------------------------CGEVLWRL------------- -------------------------------------------------- --GRKHEAAAC---------------------W----------------- -------EKTWSLT-----TQ-x-------xx------------------ -----xK-----------------------------------------LP LYLQDx-------------------------------------------- -------------------------------------------xxx-PLL DSVELRLR----------------------------------------IQ EL------------------------------------------------ ------------------------------xx-x---------------- -------- >ENSPNYP00000024241 -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ----------x-----------x--------------------------- -------------------------------------------------x xPS-------------LLEKWSQENNELVNKCK----------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ------------x-----------------------------xx------ --------------------------xxxxxxx----------------- -------------------------------------------------- -------------------------------------------------- ------------------------------------------xxLELAVV YNTCVCFTA--QSQxxxxxx--LLKEATER-------------------- --------------VLQVTG-NNA---DTx--DPLVL------------- --WRAG-------------------------------------------- -------------------------------------------------L KSAG-NTALHPHVLYLLC-------------------------------- -------------------------------------------------- -------------------------------------LQW---------- -----------------------------------------------ALW LAKCQLENIGEL-------------------------------------- ------------------------------------xxx----------- -------------------------------------------------- -------------------------xxxxxxxxx---------------- -------------------------------------------------- xxxxxxxxxxxxxSKSPLLVMEPKRLTELLQ------------------- ------------------------I--------------------CTSIA QGA--------EKLNEGRS----------------SEALSDLQAASALPA TRAL------------------------------VAYTHLLSGSCLAHMN -------------------------------------------------- ----------------RPQMAL-----QCYKKALETDSRCVCALYR---- -------------------------------------------------- ---------------------------SMLIYRQLGNT----------QA EIQALRLLHSTLMLPxA-xEP---VLG---------------------GI QP----------------------------------LSPSL--------- -------------------------------------------------- -----------------LLSSQSLSRLLSVPS------------------ -------------------------------------------------- -ALSVLYSL-----------------------------------ALKCVL S------------------------------------------------- -------------------------------------------------- -----GRVTE----------GVEHY------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ----------------------------------------LDL------- -------------------------------------------------- -------------------------------------------------- ---------------LAALH-SED-------------------------- -------------------------------------------------- -------------------------QHA---------------------- -------------------------------------------------- -----------------------------------x-----xV------- -----DAEVSV-LPRMPELYLEAGTALLFTRRPADC-------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ----------------------------------------MAFCN----- -------------------------------------------------- -------------------------------------------------- -------EVISTTLEL-----VPEKVVLE--------------------- ------EPEEGIxxx----------------------------------- -------------------------------------------------- -------------------------------xxxxxxxx----------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- E------------------------------------------------- -----------------------------------------DKVA----- ---------MLLWAAA---------------------------------- -------------------------------------------------- -------------------------------------------------- ----AYLVQGHCHAHL--KDWKQAVTHYTRCINLLVKVxxx--------- --------------------------------NR---------------x -----------------------------------------xxxxxxx-- --------A-------xx-xxxxx-------------------------- ------------KDL-----------------xT---------------- -----------------------LQRM----------------------- -------------------------------------------------- ----KGLSLAWRGISFTQM------------------------------- ---------------------------DQLREALRDLQLSL--------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- --QAFP-------------------------------------------- --------------------DYTGAGLW---------------------- -----------------------------CGEVLWRL------------- -------------------------------------------------- --GRKHEAAAC---------------------W----------------- -------EKTWSLT-----TQ-x-------xx------------------ -----xK-----------------------------------------LP LYLQDx-------------------------------------------- -------------------------------------------xxx-PLL DSVELRLR----------------------------------------IQ ELVx---------------------------------------------- ----------------------------xx-------------------- -------- >ENSHBUP00000008606 -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ----------x-----------x--------------------------- -------------------------------------------------x xPS-------------LLEKWSQENNELVNKCKxxx-xx----------- -------------------------------------------------- -------------xGAx--------------------------------- --xxxxRQ----------------------------------------SS LRW---------------------------------------------CS SEFHKLLRKI---------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ---------------------Q---------------------------- ------G------------------------------------------- ---IPPHVDHSQ-------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- --------------------------------------------LELAVV YNTCVCFTA--QSQxxxxxx--LLKEATER-------------------- --------------VLQVTG-NNA---DTx--DPLVL------------- --WRAG-------------------------------------------- -------------------------------------------------L KSAG-NTALHPHVLYLLC-------------------------------- -------------------------------------------------- -------------------------------------LQW---------- -----------------------------------------------ALW LAKCQLENIGELx------------------------------------- -----------------------------------xxxx----------- -------------------------------------------------- -------------------------xxxxxxxxx---------------- -------------------------------------------------- xxxxxxxxxxxxxSKSPLLVMEPKRLTELLQ------------------- ------------------------I--------------------CTSIA QGA--------EKLNEGRS----------------SEALSDLQAASALPA TRAL------------------------------VAYTHLLSGSCLAHMN -------------------------------------------------- ----------------RPQMAL-----QCYKRALETDSRCVCALYR---- -------------------------------------------------- ---------------------------SMLIYRQLGNT----------QA EIQALRLLHSTLMLPxA-xEP---VLG---------------------GI QP----------------------------------LSPSL--------- -------------------------------------------------- -----------------LLSSQSLSRLLSVPS------------------ -------------------------------------------------- -ALSVLYSL-----------------------------------ALKCVL S------------------------------------------------- -------------------------------------------------- -----GRVTE----------GVEHY------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ----------------------------------------LDL------- -------------------------------------------------- -------------------------------------------------- ---------------LAALH-SED-------------------------- -------------------------------------------------- -------------------------QHA---------------------- -------------------------------------------------- ------------------------------------------x------- -----DAEVSV-LPRMLELYLEAGTALLFTRRPADC-------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ----------------------------------------MAFCN----- -------------------------------------------------- -------------------------------------------------- -------EVISTTLEL-----VPEKVVLE--------------------- ------EPEEGIxxx----------------------------------- -------------------------------------------------- -------------------------------xxxxxxxx----------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- E------------------------------------------------- -----------------------------------------DKVA----- ---------MLLWAAA---------------------------------- -------------------------------------------------- -------------------------------------------------- ----AYLLQGHCHTHL--KDWKQAVTHYTRCINLLVKVxxx--------- --------------------------------NR---------------x -----------------------------------------xxxxxxx-- --------A-------xx-xxxxx-------------------------- ------------KDL-----------------xT---------------- -----------------------LQRM----------------------- -------------------------------------------------- ----KGLSLAWRGISFTQM------------------------------- ---------------------------DQLREALRDLQLSL--------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- --QAFP-------------------------------------------- --------------------DYTGAGLW---------------------- -----------------------------CGEVLWRL------------- -------------------------------------------------- --GRKHEAAAC---------------------W----------------- -------EKTWSLT-----TQ-x-------xx------------------ -----xK-----------------------------------------LP LYLQDx-------------------------------------------- -------------------------------------------xxx-PLL DSVELRLR----------------------------------------IQ EL------------------------------------------------ ------------------------------xx-x---------------- -------- >ENSACLP00000003402 -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ----------x-----------x--------------------------- -------------------------------------------------x xPS-------------LLEKWSQENNELVNKCKxxx-xx----------- -------------------------------------------------- -------------xxxx--------------------------------- --xxxxRQ----------------------------------------SS LRW---------------------------------------------CS SEFHKLLRKI---------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ---------------------Q---------------------------- ------G------------------------------------------- ---IPPHVDHSQ-------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- --------------------------------------------LELAVV YNTCVCFTA--QSQxxxxxx--LLKEATER-------------------- --------------VLQVTG-NNA---Dxx--DPLVL------------- --WRAG-------------------------------------------- -------------------------------------------------L KSAG-xTALHPHVLYLLC-------------------------------- -------------------------------------------------- -------------------------------------LQW---------- -----------------------------------------------ALW LAKCQLENIGELx------------------------------------- -----------------------------------xxxx----------- -------------------------------------------------- -------------------------xxxxxxxxx---------------- -------------------------------------------------- xxxxxxxxxxxxxSKSPLLVMEPKRLTELLQ------------------- ------------------------I--------------------CTSIA QGA--------EKLNEGRS----------------SEALSDLQAASALPA TRAL------------------------------VAYTHLLSGSCLAHMN -------------------------------------------------- ----------------RPQMAL-----QCYKRALETDSRCVCALYR---- -------------------------------------------------- ---------------------------SMLIYRQLGNT----------QA EIQALRLLHSTLMLPxA-xEP---VLG---------------------GI QP----------------------------------LSPSL--------- -------------------------------------------------- -----------------LLSSQSLSRLLSVPS------------------ -------------------------------------------------- -ALSVLYSL-----------------------------------ALKCVL S------------------------------------------------- -------------------------------------------------- -----GRVTE----------GVEHY------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ----------------------------------------LDL------- -------------------------------------------------- -------------------------------------------------- ---------------LAALH-SED-------------------------- -------------------------------------------------- -------------------------QHA---------------------- -------------------------------------------------- ------------------------------------------x------- -----DAEVSV-LPRMPELYLEAGTALLFTWRPADC-------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ----------------------------------------MAFCN----- -------------------------------------------------- -------------------------------------------------- -------EVISTTLEL-----VPEKVVLE--------------------- ------EPEEGxxxx----------------------------------- -------------------------------------------------- -------------------------------xRGxxxEx----------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- E------------------------------------------------- -----------------------------------------DKVA----- ---------MLLWAAA---------------------------------- -------------------------------------------------- -------------------------------------------------- ----AYLVQGHCHAHL--KDWKQAVTHYTRCINLLVKVxxx--------- --------------------------------NR---------------x -----------------------------------------xxxxxxx-- --------x-------xx-xxxxx-------------------------- ------------KDL-----------------xT---------------- -----------------------LQRM----------------------- -------------------------------------------------- ----KGLSLAWRGISFTQM------------------------------- ---------------------------DQLREALRDLQLSL--------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- --QAFP-------------------------------------------- --------------------DYTGAGLW---------------------- -----------------------------CGEVLWRL------------- -------------------------------------------------- --GRKHEAAAC---------------------W----------------- -------EKTWSLT-----TQ-x-------xx------------------ -----xK-----------------------------------------LP LYLQDx-------------------------------------------- -------------------------------------------xxx-PLL DSVELRFR----------------------------------------IQ EL------------------------------------------------ ------------------------------xx-x---------------- -------- >ENSMZEP00005022589 -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ----------x-----------x--------------------------- -------------------------------------------------x xPS-------------LPEKWSQENNELVNKCKxxx-xx----------- -------------------------------------------------- -------------xGAx--------------------------------- --xxxxRQ----------------------------------------SS LRW---------------------------------------------CS SEFHKLLRKI---------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ---------------------Q---------------------------- ------G------------------------------------------- ---IPPHVDHSQ-------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- --------------------------------------------LELAVV YNTCVCFTA--QSQxxxxxx--LLKEATER-------------------- --------------VLQVTG-NNA---DTx--DPLVL------------- --WRAG-------------------------------------------- -------------------------------------------------L KSAG-NTALHPHVLYLLC-------------------------------- -------------------------------------------------- -------------------------------------LQW---------- -----------------------------------------------ALW LAKCQLENIGELx------------------------------------- -----------------------------------xxxx----------- -------------------------------------------------- -------------------------xxxxxxxxx---------------- -------------------------------------------------- xxxxxxxxxxxxxSKSPLLVMEPKRLTELLQ------------------- ------------------------I--------------------CTSIA QGA--------EKLNEGRS----------------SEALSVLQAASALPA TRAL------------------------------VAYTHLLSGSCLAHMN -------------------------------------------------- ----------------RPQMAL-----QCYKRALETDSRCVCALYR---- -------------------------------------------------- ---------------------------SMLIYRQLGNT----------QA EIQALRLLHSTLMLPxA-xEP---VLG---------------------GI QP----------------------------------LSPSL--------- -------------------------------------------------- -----------------LLSSQSLSRLLSVPS------------------ -------------------------------------------------- -ALSVLYSL-----------------------------------ALKCVL S------------------------------------------------- -------------------------------------------------- -----GRVTE----------GVEHY------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ----------------------------------------LDL------- -------------------------------------------------- -------------------------------------------------- ---------------LAALH-SED-------------------------- -------------------------------------------------- -------------------------QHA---------------------- -------------------------------------------------- ------------------------------------------x------- -----DAEVSV-LPRMPELYLEAGTALLFTRRPADC-------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ----------------------------------------MAFCN----- -------------------------------------------------- -------------------------------------------------- -------EVISTTLEL-----VPEKVVLE--------------------- ------EPEEGIxxx----------------------------------- -------------------------------------------------- -------------------------------xxxxxxxx----------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- E------------------------------------------------- -----------------------------------------DKVA----- ---------MLLWAAA---------------------------------- -------------------------------------------------- -------------------------------------------------- ----AYLVQGHCHAHL--KDWKQAVTHYTRCINLLVKVxxx--------- --------------------------------NR---------------x -----------------------------------------xxxxxxx-- --------A-------xx-xxxxx-------------------------- ------------KDL-----------------xT---------------- -----------------------LQRM----------------------- -------------------------------------------------- ----KGLSLAWRGISFTQM------------------------------- ---------------------------DQLREALRDLQLSL--------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- --QAFP-------------------------------------------- --------------------DYTGAGLW---------------------- -----------------------------CGEVLWRL------------- -------------------------------------------------- --GRKHEAAAC---------------------W----------------- -------EKTWSLT-----TQ-x-------xx------------------ -----xK-----------------------------------------LP LYLQDx-------------------------------------------- -------------------------------------------xxx-PLL DSVELRFR----------------------------------------IQ EL------------------------------------------------ ------------------------------xx-x---------------- -------- >ENSONIP00000017184 -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ----------x-----------x--------------------------- -------------------------------------------------x xPS-------------LLEKWIQENNELVNKCKxQE-Ax----------- -------------------------------------------------- -------------xGVx--------------------------------- --xxxxSQ----------------------------------------SS LRW---------------------------------------------CS SEFHKLLRKI---------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ---------------------Q---------------------------- ------G------------------------------------------- ---IPPHVDHTQ-------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- --------------------------------------------LELAVV CNTCVCFTA--QSQxxxxxx--LLKEATER-------------------- --------------VLQMTG-NNA---DTx--DPLVL------------- --WRAV-------------------------------------------- -------------------------------------------------L KSAG-NTALHPHVLYLLC-------------------------------- -------------------------------------------------- -------------------------------------LQW---------- -----------------------------------------------TLW LAKCQLENIGELx------------------------------------- -----------------------------------xxxx----------- -------------------------------------------------- -------------------------xxxxxxxxx---------------- -------------------------------------------------- xxxxxxxxxxxxxAKSPLLVMDPKRLTELLQ------------------- ------------------------I--------------------CTSIA QGA--------EKLNEGRS----------------SEALSDLQAASTMPA TRAL------------------------------VAYTHLLSGSCLAHMN -------------------------------------------------- ----------------RPQMAL-----QCYKKALETDSRCVCALYR---- -------------------------------------------------- ---------------------------SMLIYRQLGNT----------QA EIQALRLLHSTLMLPxA-xEP---VLG---------------------GI HP----------------------------------ISPSL--------- -------------------------------------------------- -----------------LLSSQSLSRLFSVPS------------------ -------------------------------------------------- -ALSVLYSL-----------------------------------ALKCVL S------------------------------------------------- -------------------------------------------------- -----GRVTE----------GVEHY------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ----------------------------------------LDL------- -------------------------------------------------- -------------------------------------------------- ---------------LAALH-SED-------------------------- -------------------------------------------------- -------------------------QHA---------------------- -------------------------------------------------- -----------------------------------x-----xV------- -----DAEVSV-LPRMLELYLEAGTALLITRRPADC-------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ----------------------------------------MALCN----- -------------------------------------------------- -------------------------------------------------- -------EVISTTLEL-----VPEKVVLE--------------------- ------EPEERIxxx----------------------------------- -------------------------------------------------- -------------------------------xxxxxxxx----------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- E------------------------------------------------- -----------------------------------------DKVA----- ---------MLLWAAA---------------------------------- -------------------------------------------------- -------------------------------------------------- ----AYLLQGHCHAHL--KDWKQAVTHYTRCINLVVKVxxx--------- --------------------------------NR---------------x -----------------------------------------xxxxxxx-- --------A-------xx-xxxxx-------------------------- ------------KDL-----------------xA---------------- -----------------------LQRM----------------------- -------------------------------------------------- ----KGLSLAWRGISFTQM------------------------------- ---------------------------DQLREALRDLQLSL--------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- --QAFP-------------------------------------------- --------------------DYTGAGLW---------------------- -----------------------------CGEVLWRL------------- -------------------------------------------------- --GRKHEAAAC---------------------W----------------- -------EKTWSLT-----TQ-x-------xx------------------ -----xK-----------------------------------------LP LYLQDx-------------------------------------------- -------------------------------------------xxx-PLL DSVELRLR----------------------------------------IQ EL------------------------------------------------ ------------------------------xx-x---------------- -------- >ENSSPAP00000022701 -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ----------x-----------x--------------------------- -------------------------------------------------x xLS-------------LLDTWVQENNELVNKCKxK--------------- ----------------------------x--------------------- ------------xxxxx--------------------------------- --xxxxSQ----------------------------------------PP LKW---------------------------------------------FS FEFHKLLRKI---------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ---------------------Q---------------------------- ------G------------------------------------------- ---IPPNADHTQ-------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- --------------------------------------------LELAVV FNAGVCSAA--QSQxxxxxx--FLAQATER-------------------- --------------VLQMTG-GDA---GAx--DPLVR------------- --WRTV-------------------------------------------- -------------------------------------------------L NSVG-DTALHPSVLYLLC-------------------------------- -------------------------------------------------- -------------------------------------LQW---------- -----------------------------------------------AIW LATCQLKTIQEFx------------------------------------- -----------------------------------x-xx----------- -------------------------------------------------- -------------------------xxxxxxxxx---------------- -------------------------------------------------- xxxxxxxxxxxxxSNIPLLVMDPRRLIELLQ------------------- ------------------------I--------------------CTSIA LGA--------ERLNEGRS----------------SEALSSLQAASALPA PRAL------------------------------VAYTHLLSGSCLTHMR -------------------------------------------------- ----------------RPQMAL-----QCYRKALETDSRCVCALYQ---- -------------------------------------------------- ---------------------------SMLIYRQLGNT----------QA EIQALRLLHSTLMLPxA-xEP---ALG---------------------ST HL----------------------------------LSPSL--------- -------------------------------------------------- -----------------LLRSQSLSSLLSVPS------------------ -------------------------------------------------- -ALTVLHSL-----------------------------------ALKCVL Y------------------------------------------------- -------------------------------------------------- -----GRVSE----------GVEHY------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ----------------------------------------LDL------- -------------------------------------------------- -------------------------------------------------- ---------------LAVVH-SED-------------------------- -------------------------------------------------- -------------------------QQG---------------------- -------------------------------------------------- ------------------------------------------x------- -----HTEDAT-LPKLPELYLEAGAALLMARRPADC-------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ----------------------------------------LALCN----- -------------------------------------------------- -------------------------------------------------- -------EVNSTTLEL-----LPEKVVLE--------------------- ------EPEERxxxx----------------------------------- -------------------------------------------------- -------------------------------xxxx--EG----------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- E------------------------------------------------- -----------------------------------------NSLA----- ---------MVLWTAA---------------------------------- -------------------------------------------------- -------------------------------------------------- ----AYLLQGHCHSHL--KDWKQAVTHYTRCINLLVKVxxx--------- --------------------------------KR---------------x -----------------------------------------xxxxxxx-- --------A-------xx-xxxxx-------------------------- ------------KDL-----------------xV---------------- -----------------------LERL----------------------- -------------------------------------------------- ----KGLSLAGRGICFIQI------------------------------- ---------------------------DKLKEALRDLQLGL--------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- --QTFP-------------------------------------------- --------------------ECVGAGLW---------------------- -----------------------------CGEVLWRL------------- -------------------------------------------------- --RRRREAAAC---------------------W----------------- -------EKTWSLT-----TQ-x-------xx------------------ -----xS-----------------------------------------LP VYLQEx-------------------------------------------- -------------------------------------------xxx-PLL DSTELRHR----------------------------------------IQ EL------------------------------------------------ ------------------------------xx-x---------------- -------- >ENSAOCP00000026117 xx------------------------------------------------ -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- --------xxx-----------x--------------------------- -------------------------------------------------x xPS-------------LLDKWIQENNELVNKCKxx--------------- ----------------------------x--------------------- ------------xxxxx--------------------------------- --xxxxNQ----------------------------------------PH LRW---------------------------------------------CS YEFHKLLRKI---------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ---------------------Q---------------------------- ------G------------------------------------------- ---IPPNTDHTQ-------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- --------------------------------------------LELAVV YNTGVCATA--QSQxxxxxx--FLTQAAER-------------------- --------------VLQMTG-GET---GAx--DPLVC------------- --WRAV-------------------------------------------- -------------------------------------------------L KSVE-NTHLHPTVLYLLC-------------------------------- -------------------------------------------------- -------------------------------------LQW---------- -----------------------------------------------AIW LATCQLETIQEFx------------------------------------- -----------------------------------xxxx----------- -------------------------------------------------- -------------------------xxxxxxxxx---------------- -------------------------------------------------- xxxxxxxxxxxxxSNIPLLVMDPRRLIELLQ------------------- ------------------------I--------------------CTSIT LGA--------ERLTEGRS----------------SEALTGLQAASSLPA PRAL------------------------------VGYTHLLSGSCLTHMR -------------------------------------------------- ----------------RPQMAL-----QCYRKALETDSRCVCALYQ---- -------------------------------------------------- ---------------------------SMLIYRQLGNT----------QA EIQALRLLHSTLMLPxA-xDP---ALA---------------------ST HL----------------------------------LSPSS--------- -------------------------------------------------- -----------------LLCSQSLSSLLSVPS------------------ -------------------------------------------------- -ALSVLHSL-----------------------------------ALKCLL Y------------------------------------------------- -------------------------------------------------- -----GRVSE----------GVEHY------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ----------------------------------------LDL------- -------------------------------------------------- -------------------------------------------------- ---------------LAVLH-SED-------------------------- -------------------------------------------------- -------------------------QQG---------------------- -------------------------------------------------- ------------------------------------------x------- -----HTQDAT-IPRLPELYLEAGAALLMARRPADC-------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ----------------------------------------LALCS----- -------------------------------------------------- -------------------------------------------------- -------EVISTTLEL-----LPEKVVLE--------------------- ------EPEERxxxx----------------------------------- -------------------------------------------------- -------------------------------xxxx--EG----------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- E------------------------------------------------- -----------------------------------------NRVA----- ---------VVLWTAA---------------------------------- -------------------------------------------------- -------------------------------------------------- ----AYLLQGHCHSHL--KDWKQAVTHYTRCINLVVKVxxx--------- --------------------------------KR---------------x -----------------------------------------xxxxxxx-- --------A-------xx-xxxxx-------------------------- ------------NDQ-----------------xV---------------- -----------------------LQRL----------------------- -------------------------------------------------- ----KGLSLAGRGISFTQT------------------------------- ---------------------------DKLKEALRDLQLSL--------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- --QAFP-------------------------------------------- --------------------ECVGAGLW---------------------- -----------------------------CGEVLWRL------------- -------------------------------------------------- --SRRREAAAC---------------------W----------------- -------EKTWSLT-----TQ-x-------xx------------------ -----xN-----------------------------------------LP VYLQEx-------------------------------------------- -------------------------------------------xxx-PLL DSAELCHR----------------------------------------IQ EL------------------------------------------------ ------------------------------xx-x---------------- -------- >ENSAPEP00000029923 -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ----------x-----------x--------------------------- -------------------------------------------------x xPS-------------LLDKWIQENNELVNKCK----------------- -------------------------------------------------- -------------------------------------------------- ----xxxx----------------------------------------xH LRW---------------------------------------------CS YEFHKLLRKI---------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ---------------------Q---------------------------- ------G------------------------------------------- ---IPPNADHTQ-------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- --------------------------------------------LELAVV YNAGVCATA--QSQxxxxxx--FLTQAAER-------------------- --------------VLQMTG-GET---GAx--DPLVR------------- --WRAV-------------------------------------------- -------------------------------------------------L KSVE-NTHLHPTVLYLLC-------------------------------- -------------------------------------------------- -------------------------------------LQW---------- -----------------------------------------------AIW LATCQLETIQEFx------------------------------------- -------------------------------------xx----------- -------------------------------------------------- -------------------------xxxxxxxxx---------------- -------------------------------------------------- xxxxxxxxxxxxxSNIPLLAMDPRRLIELLQ------------------- ------------------------I--------------------CTSIT LGA--------ERLTEGRS----------------SEALTGLQAALSLPA PRAL------------------------------VGYTHLLSGSCLTHMR -------------------------------------------------- ----------------RPQMAL-----QCYRKALETDSRCVCALYQ---- -------------------------------------------------- ---------------------------SMLIYRQLGNT----------QA EIQALRLLHSTLMLPxA-xVP---ALA---------------------ST HL----------------------------------LSPSS--------- -------------------------------------------------- -----------------LLCSQSLSSLLSVPS------------------ -------------------------------------------------- -ALSVLHSL-----------------------------------ALKCLL Y------------------------------------------------- -------------------------------------------------- -----GRVSE----------GVEHY------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ----------------------------------------LDL------- -------------------------------------------------- -------------------------------------------------- ---------------LAVLH-SED-------------------------- -------------------------------------------------- -------------------------QQG---------------------- -------------------------------------------------- -----------------------------------V-----xL------- -----HTQDAT-IPRLPELYLEAGAALLMARRPADC-------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ----------------------------------------LALCS----- -------------------------------------------------- -------------------------------------------------- -------EVISTTLEL-----LPEKVVLE--------------------- ------EPEKRxxxx----------------------------------- -------------------------------------------------- -------------------------------xxxx--EG----------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- E------------------------------------------------- -----------------------------------------NRVA----- ---------VVLWTAA---------------------------------- -------------------------------------------------- -------------------------------------------------- ----AYLLQGHCHSHL--KDWKQAVTHYTRCINLLVKVxxx--------- --------------------------------KR---------------x -----------------------------------------xxxxxxx-- --------A-------xx-xxxxx-------------------------- ------------KDQ-----------------xV---------------- -----------------------LQRL----------------------- -------------------------------------------------- ----KGLSLAGRGISFTQT------------------------------- ---------------------------DKLKEALRDLQLSL--------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- --QAFP-------------------------------------------- --------------------ECVGAGLW---------------------- -----------------------------CGEVLWRL------------- -------------------------------------------------- --SRRREAAAC---------------------W----------------- -------EKTWSLT-----TQ-x-------xx------------------ -----xN-----------------------------------------LP VYLQEx-------------------------------------------- -------------------------------------------xxx-PLL DSAELRHR----------------------------------------IQ EL------------------------------------------------ ------------------------------xx-x---------------- -------- >ENSSDUP00000020106 -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ----------x-----------x--------------------------- -------------------------------------------------x xxS-------------LVNKWVQENNELVNKWK----------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ----------------------x-xx----------xxxxxxxxxxxxxx xxxxxxG------------------------------------------- ---VPPLADHTH-------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- --------------------------------------------LELSVV YNTCVCATA--QSQxxxxxx--LLTQALQR-------------------- --------------ALQITG-NDS---VTx--ETPVF------------- --WRTV-------------------------------------------- -------------------------------------------------L KSVA-NTALNSCVLYLLC-------------------------------- -------------------------------------------------- -------------------------------------LQW---------- -----------------------------------------------AIW LATCQLKTIQEFx------------------------------------- -------------------------------------xx----------- -------------------------------------------------- -------------------------xxxxxxxxx---------------- -------------------------------------------------- xxxxxxxxxxxxxSDVPLLVTDPRKLVELLQ------------------- ------------------------I--------------------CTSIA QGV--------ERLSEGQC----------------SEALSDLQSASSLPA PRAL------------------------------VAYVHLLSGS-----x x------------------------------------------------- --------------xxRPQMAL-----QCYRKALETDSCCVCALYQ---- -------------------------------------------------- ---------------------------SMLIYRQLGNT----------QA EIQALRLLHSTLMLLxA-xVP---TVA---------------------GA HL----------------------------------LSPSL--------- -------------------------------------------------- -----------------LLCSQSLRDLLSVPS------------------ -------------------------------------------------- -APSVLHNL-----------------------------------ALKCVL H------------------------------------------------- -------------------------------------------------- -----GRVSE----------GVEHY------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ----------------------------------------LDL------- -------------------------------------------------- -------------------------------------------------- ---------------LAALH-SED-------------------------- -------------------------------------------------- -------------------------QHG---------------------- -------------------------------------------------- -----------------------------------x-----xV------- -----HGEATP-LPRLPQLYLETGAALLMARRPADC-------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ----------------------------------------MALCN----- -------------------------------------------------- -------------------------------------------------- -------EVISTTLEL-----LPEKLVLE--------------------- ------DPEDRxxxx----------------------------------- -------------------------------------------------- -------------------------------xxxxxxxx----------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- E------------------------------------------------- -----------------------------------------DKVA----- ---------MLLWTGA---------------------------------- -------------------------------------------------- -------------------------------------------------- ----AFLLQGHCHTHL--MDWKKAVTHYTRCINLLVKVxxx--------- --------------------------------KK---------------x -----------------------------------------xxxxxxx-- --------A-------xx-xxxxx-------------------------- ------------TDL-----------------xT---------------- -----------------------LQRL----------------------- -------------------------------------------------- ----KGLSLAGRGISFTQT------------------------------- ---------------------------DRLREALRDLLLSL--------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- --QAFP-------------------------------------------- --------------------ECVGAGLW---------------------- -----------------------------CGEVLWRL------------- -------------------------------------------------- --GRRQEAAAC---------------------W----------------- -------EKTWxxT-----xx----------------------------- ------G-----------------------------------------LP LYLQEx-------------------------------------------- -------------------------------------------xxx-PSL DSTKLKRR----------------------------------------IQ EL------------------------------------------------ ------------------------------xx-x---------------- -------- >ENSSLDP00000001852 -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ----------x-----------x--------------------------- -------------------------------------------------x xxS-------------LVNKWVQENNELVNKWKxxx-xx----------- -------------------------------------------------- -------------xxTx--------------------------------- --xxxxNQ----------------------------------------SH LRC---------------------------------------------SS SEFYRLLRKI---------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ---------------------Q---------------------------- ------G------------------------------------------- ---VPPLADHTH-------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- --------------------------------------------LELSVV YNTCVCATA--QSQxxxxxx--LLTQALRR-------------------- --------------ALQITG-NDS---VTx--ETPVF------------- --WRTV-------------------------------------------- -------------------------------------------------L KSVA-NTALNSCVLYLLC-------------------------------- -------------------------------------------------- -------------------------------------LQW---------- -----------------------------------------------AIW LATCQLKTIQEFx------------------------------------- -----------------------------------xxxx----------- -------------------------------------------------- -------------------------xxxxxxxxx---------------- -------------------------------------------------- xxxxxxxxxxxxxSDVPLLVTDPRKLVELLQ------------------- ------------------------I--------------------CTSIA QGV--------ERLSEGQC----------------SEALSDLQSASALPA PRAL------------------------------VAYVHLLSGSCLAHMS -------------------------------------------------- ----------------RPQMAL-----QCYRKALETDSCSVCALYQ---- -------------------------------------------------- ---------------------------SMLIYRQLGNT----------QA EIQALRLLHSSLMLPxA-xVP---TVA---------------------GA HL----------------------------------LSPSL--------- -------------------------------------------------- -----------------LLCSQSLRDLLSVPS------------------ -------------------------------------------------- -APSVLHNL-----------------------------------ALKCVL H------------------------------------------------- -------------------------------------------------- -----GRVSE----------GVEHY------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ----------------------------------------LDL------- -------------------------------------------------- -------------------------------------------------- ---------------LAALH-SED-------------------------- -------------------------------------------------- -------------------------QHG---------------------- -------------------------------------------------- ------------------------------------------x------- -----HGEATP-LPRLPQLYLETGAALLMARRPADC-------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ----------------------------------------MALCN----- -------------------------------------------------- -------------------------------------------------- -------EVISTTLEL-----LPEKLVLE--------------------- ------DPEDRxxxx----------------------------------- -------------------------------------------------- -------------------------------xxxxxxxx----------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- E------------------------------------------------- -----------------------------------------DMVA----- ---------MLLWTGA---------------------------------- -------------------------------------------------- -------------------------------------------------- ----AFLLQGHCHTHL--TDWKQAVTHYTRCINLLVKVxxx--------- --------------------------------KK---------------x -----------------------------------------xxxxxxx-- --------A-------xx-xxxxx-------------------------- ------------TDL-----------------xT---------------- -----------------------LQRL----------------------- -------------------------------------------------- ----KGLSLAGRGISFTQT------------------------------- ---------------------------DRLREALRDLLLSL--------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- --QAFP-------------------------------------------- --------------------ECVGAGLW---------------------- -----------------------------CGEVLWRL------------- -------------------------------------------------- --GRRQEAAAC---------------------W----------------- -------EKTWSFT-----TQ-x-------xx------------------ -----xG-----------------------------------------LP LYLQEx-------------------------------------------- -------------------------------------------xxx-PSL DSTELRRR----------------------------------------IQ EL------------------------------------------------ ------------------------------xx-x---------------- -------- >ENSLCAP00010060539 xx------------------------------------------------ -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- --------xxx-----------x--------------------------- -------------------------------------------------x xTN-------------LLNKWVQENNELVNKCKxxx-xx----------- -------------------------------------------------- -------------xxTx--------------------------------- --xxxxNQ----------------------------------------TP LRS---------------------------------------------YS SEFHKLLRKI---------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ---------------------Q---------------------------- ------G------------------------------------------- ---VPPLVNHTH-------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- --------------------------------------------LELSVV YNACVCSTA--QSQxxxxxx--LLIQAIQR-------------------- --------------ALQMTG-DEP---VAx--NRTVF------------- --WRTV-------------------------------------------- -------------------------------------------------L KSVG-NTTFNTCVRYLLC-------------------------------- -------------------------------------------------- -------------------------------------LQW---------- -----------------------------------------------AIW LATCQLTIIQELx------------------------------------- -----------------------------------xxxx----------- -------------------------------------------------- -------------------------xxxxxxxxx---------------- -------------------------------------------------- xxxxxxxxxxxxxSDIPLLVTDPRGLVELLQ------------------- ------------------------I--------------------CTSII QGA--------ERLSEGQS----------------SEALSALQTASSLPA PRAL------------------------------LAYVHFLSGSCLAHMS -------------------------------------------------- ----------------RPQMAL-----QCYRKALVTDACCVSALYQ---- -------------------------------------------------- ---------------------------SMLIYRQLGNT----------QA EIQALRLLQSTLMLPxV-xVP---ALA---------------------TT HL----------------------------------LSPSL--------- -------------------------------------------------- -----------------LLCSQSLSSLLSVPS------------------ -------------------------------------------------- -ALSVLHSL-----------------------------------ALKCVL H------------------------------------------------- -------------------------------------------------- -----GRVSE----------GVEHY------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ----------------------------------------LDL------- -------------------------------------------------- -------------------------------------------------- ---------------LAALH-SED-------------------------- -------------------------------------------------- -------------------------QHG---------------------- -------------------------------------------------- ------------------------------------------V------- -----HAEAPA-LPRLPELYLEAGAALLMARRPADC-------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ----------------------------------------MALCN----- -------------------------------------------------- -------------------------------------------------- -------EVISTTLEL-----LPEKVVLE--------------------- ------DPEETxxxx----------------------------------- -------------------------------------------------- -------------------------------xxxxxxxx----------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- E------------------------------------------------- -----------------------------------------DRVG----- ---------MLLWTGA---------------------------------- -------------------------------------------------- -------------------------------------------------- ----AYLLQGHCHTHL--KDWKQAVTHYTRCINLLVRVxxx--------- --------------------------------KK---------------x -----------------------------------------xxxxxxx-- --------G-------xx-xxxxx-------------------------- ------------THL-----------------xI---------------- -----------------------LQRL----------------------- -------------------------------------------------- ----KGLSLAGRGISFTQT------------------------------- ---------------------------DQLKEALRDLLLSL--------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- --QASP-------------------------------------------- --------------------ECVGAGLW---------------------- -----------------------------CGEVLWRL------------- -------------------------------------------------- --GRRQEAAAC---------------------W----------------- -------EKTWSFT-----TQxx-------xx------------------ -----xG-----------------------------------------LP VYLQEx-------------------------------------------- -------------------------------------------xxx-PLL DSTELRHR----------------------------------------IQ EL------------------------------------------------ ------------------------------xx-x---------------- -------- >ENSSMAP00000017476 -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ----------x-----------x--------------------------- -------------------------------------------------x xxC-------------LLNTWVQENNELVKKWK----------------- -------------------------------------------------- -------------------------------------------------- --xxxxxx----------------------------------------TH LRW---------------------------------------------CS SEFYKLLRKT---------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ---------------------Q---------------------------- ------G------------------------------------------- ---VPPHPDHVH-------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- --------------------------------------------LELSVV YNACVCATV--QSQxxxxxx--LLTQAIQR-------------------- --------------ALQMTS-DDP---VAx--DLPAF------------- --WRKV-------------------------------------------- -------------------------------------------------L RSVV-NTAFNSCVLDLLC-------------------------------- -------------------------------------------------- -------------------------------------LQW---------- -----------------------------------------------AMW LATCQLKTIQEFx------------------------------------- -------------------------------------xx----------- -------------------------------------------------- -------------------------xxxxxxxxx---------------- -------------------------------------------------- xxxxxxxxxxxxxSDAPLLVTDPRRLVELLQ------------------- ------------------------I--------------------CTSIA QGA--------ERLSEDQS----------------SEALSGLQKASSLPA PRTL------------------------------VAYVHLLSGSCLSHMN -------------------------------------------------- ----------------CPQMAL-----QCYRKALETDSCCVCALYQ---- -------------------------------------------------- ---------------------------SMLIYRQLGNT----------QA EIQALRLLHSMLMLPxA-xVP---ALA---------------------GT HL----------------------------------FSPSL--------- -------------------------------------------------- -----------------LLCSQSLSSLLLVPS------------------ -------------------------------------------------- -ALSVLHNL-----------------------------------ALKCAL H------------------------------------------------- -------------------------------------------------- -----GRVSE----------GVEHY------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ----------------------------------------LDL------- -------------------------------------------------- -------------------------------------------------- ---------------LAALH-SED-------------------------- -------------------------------------------------- -------------------------QHG---------------------- -------------------------------------------------- -----------------------------------x-----xV------- -----YAEAPR-LPRLPELYLEAGAALLMARRSADC-------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ----------------------------------------MALCN----- -------------------------------------------------- -------------------------------------------------- -------EVISTTLEL-----LPERLVLE--------------------- ------DPEERxxxx----------------------------------- -------------------------------------------------- -------------------------------xxxxxxxx----------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- E------------------------------------------------- -----------------------------------------DKMA----- ---------MLLWAGA---------------------------------- -------------------------------------------------- -------------------------------------------------- ----AYLLQGHCHTHL--KDWKQAVNHFTRCINLLVKVxxx--------- --------------------------------K----------------- -------------------------------------------------- --------x-------xx-xxxxx-------------------------- ------------SDL-----------------xV---------------- -----------------------LQRL----------------------- -------------------------------------------------- ----KGLSLAGRGIAFTQT------------------------------- ---------------------------NHLREALRDLLLSL--------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- --QAFP-------------------------------------------- --------------------ECVGAGLW---------------------- -----------------------------CGEVLWRL------------- -------------------------------------------------- --GRRQEAVAC---------------------W----------------- -------EKTWSFT-----TQ-x-------xx------------------ -----xG-----------------------------------------LP LYLREx-------------------------------------------- -------------------------------------------xxx-PLL DSKELRHR----------------------------------------IQ EL------------------------------------------------ ------------------------------xx-x---------------- -------- >ENSCGOP00000029237 xx------------------------------------------------ -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- --------xxx-----------x--------------------------- -------------------------------------------------x xHS-------------LLDIWIQENNELVNKWKxQE-xxxx--------- --------------------------xxx--------------------- ------------xx------------------------------------ ----SQNQ----------------------------------------TH LRL---------------------------------------------CS SEFNKLLRKI---------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ---------------------Q---------------------------- ------G------------------------------------------- ---IPPLADHTQ-------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- --------------------------------------------LELTVV YNACVCSMA--QSQxxxxxx--LLQQATER-------------------- --------------VLQMTG-DDP---VAx--DPTGF------------- --WRTV-------------------------------------------- -------------------------------------------------L KSVG-NTALTPCVLSLLC-------------------------------- -------------------------------------------------- -------------------------------------LQW---------- -----------------------------------------------AIW LSTCQLKTIQEFx------------------------------------- -----------------------------------xxxx----------- -------------------------------------------------- -------------------------xxxxxxxxx---------------- -------------------------------------------------- xxxxxxxxxxxxxSDIPLLVMDPRRLVELLQ------------------- ------------------------I--------------------CTLIA QGA--------ERLSEGRS----------------SEALSGLQSAFSLPA PRTL------------------------------IAYTHLLSGSCLAHMS -------------------------------------------------- ----------------RPQMAL-----QCYRKALETDSQCVCALYQ---- -------------------------------------------------- ---------------------------SMLIYRQLGNT----------QA EIQALRLLHSTLTLPxA-xEP---ALA---------------------GT HL----------------------------------LSPSL--------- -------------------------------------------------- -----------------LLCSRSLSSLLSVPS------------------ -------------------------------------------------- -ALSVLHNL-----------------------------------ALNCVL H------------------------------------------------- -------------------------------------------------- -----GRLSE----------GVEYY------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ----------------------------------------LDL------- -------------------------------------------------- -------------------------------------------------- ---------------LAALH-SED-------------------------- -------------------------------------------------- -------------------------QHG---------------------- -------------------------------------------------- ------------------------------------------x------- -----HAEGPP-LPRLPELYLQAGAALLMARRPADC-------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ----------------------------------------MALCD----- -------------------------------------------------- -------------------------------------------------- -------EVITTTLEL-----LPEKVVLE--------------------- ------EPEEExxxx----------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ---------------------------------------------xxxxx xxxxxxxxxMLLWAGA---------------------------------- -------------------------------------------------- -------------------------------------------------- ----AYLLQGHCYTHL--KDWKPAVTHYTRCFNLLVKVxxx--------- --------------------------------KR---------------x -----------------------------------------xxxxxxx-- --------A-------xx-xxxxx-------------------------- ------------TDL-----------------xI---------------- -----------------------LQRL----------------------- -------------------------------------------------- ----KGLSLAGRGISFTQT------------------------------- ---------------------------DQLREALRDLQLSM--------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- --QALP-------------------------------------------- --------------------ECAGAGLW---------------------- -----------------------------CGEVLWRL------------- -------------------------------------------------- --GRRREAAAC---------------------W----------------- -------EKTWSFT-----PQ-x-------xx------------------ -----xS-----------------------------------------LS VYLQEx-------------------------------------------- -------------------------------------------xxx-PLL DSMELRRR----------------------------------------IQ EL------------------------------------------------ ------------------------------xx-xxx-------------- -------x >ENSLCRP00005000898 xx------------------------------------------------ -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- --------xxx-----------x--------------------------- -------------------------------------------------x xPS-------------LLDRWMQENNELVNKWQxKA-xxxx--------- --------------------------xxx--------------------- -------------------------------------------------- -----xxK----------------------------------------TH LRS---------------------------------------------CS SEFHKLLQKI---------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ---------------------Q---------------------------- ------G------------------------------------------- ---VPPLADHTQ-------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- --------------------------------------------LELTVV YNACVCSVA--QSHxxxxxx--LLIQATER-------------------- --------------VLQITG-DNP---VAx--DPPVF------------- --WKTA-------------------------------------------- -------------------------------------------------L KSVA-NTALNSSIQYILC-------------------------------- -------------------------------------------------- -------------------------------------LQW---------- -----------------------------------------------AIW LATCQLKTIQEFx------------------------------------- -----------------------------------xxxxxxxxxx----- -xxxxxxxxxx--------------------------------------- -----------------------xxx------------------------ -------------------------------------------------- ----------xxxSDIPLLVMDPRRLFELLQ------------------- ------------------------I--------------------CTYIA QGA--------EKLSEGQS----------------SEALSVLQTASSLPA PKTL------------------------------VAYTHLLSGSCLTHMS -------------------------------------------------- ----------------CPQMAL-----QCYRKALETDSWCVCALYQ---- -------------------------------------------------- ---------------------------SMLIYRQLSNT----------QA EIQALRLLHSTLMLPxA-xEP---ALA---------------------GT HL----------------------------------LSPSL--------- -------------------------------------------------- -----------------LLCSKPLNSLLSVPS------------------ -------------------------------------------------- -ALFVLHSL-----------------------------------AQKCVI Y------------------------------------------------- -------------------------------------------------- -----GRVSE----------GVECY------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ----------------------------------------LDL------- -------------------------------------------------- -------------------------------------------------- ---------------LNTLH-SED-------------------------- -------------------------------------------------- -------------------------QHG---------------------- -------------------------------------------------- ------------------------------------------x------- -----HTEVHS-LPRLPELYLEAGAALLMARRPTDC-------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ----------------------------------------MALCD----- -------------------------------------------------- -------------------------------------------------- -------EVISTTLEL-----LPDKLVLE--------------------- ------EPEEKxxxx----------------------------------- -------------------------------------------------- -------------------------------xxxxxxxx----------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- E------------------------------------------------- -----------------------------------------DRVG----- ---------MLLWTGA---------------------------------- -------------------------------------------------- -------------------------------------------------- ----AYLLQGHCHTNL--KDWKQAVTHYTRCINLLVKVxxx--------- --------------------------------RR---------------G -----------------------------------------xxxxxxx-- --------V-------xx-xxxxx-------------------------- ------------TDL-----------------xI---------------- -----------------------LQRL----------------------- -------------------------------------------------- ----KGLSLAGRGISFSQT------------------------------- ---------------------------DQLREALRDLQLSL--------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- --QAFP-------------------------------------------- --------------------DCVGAGLW---------------------- -----------------------------CGEVLWRL------------- -------------------------------------------------- --GRRREAAAC---------------------W----------------- -------EKTWSFT-----TQ-x-------xx------------------ -----xN-----------------------------------------LS LYLKEx-------------------------------------------- -------------------------------------------xxx-PLL DSTELRHR----------------------------------------IQ GL------------------------------------------------ ------------------------------xx-xxx-------------- -------x >ENSMALP00000016358 xx------------------------------------------------ -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- --------xxx-----------x--------------------------- -------------------------------------------------x xxS-------------LFDKWVQENNNLVNKWKxxx-xx----------- -------------------------------------------------- -------------xxTx--------------------------------- --xxxxSQ----------------------------------------TH LKW---------------------------------------------CT SEFETLLRKI---------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ---------------------Q---------------------------- ------G------------------------------------------- ---VPPLADHTQ-------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- --------------------------------------------LEVSVV YNACVCFTA--QSQxxxxxx--LLKQATER-------------------- --------------ALQMAG-NFP---VAx--DPPVL------------- --WRTV-------------------------------------------- -------------------------------------------------L KSVE-NTALNSCVLYLLC-------------------------------- -------------------------------------------------- -------------------------------------LQW---------- -----------------------------------------------AIW LATCQLKMIEEFx------------------------------------- -----------------------------------xxxx----------- -------------------------------------------------- -------------------------xxxxxxxxx---------------- -------------------------------------------------- xxxxxxxxxxxxxFDISLLVMEPRRLVELLQ------------------- ------------------------I--------------------CTSIA QGA--------ERLSEGHS----------------SEALSGLQIASSLPA PRIL------------------------------VAYTHFLSGSCLAHMS -------------------------------------------------- ----------------RPQMAL-----QCYRKALETDFRCVCALYQ---- -------------------------------------------------- ---------------------------SMLIYRQLGNT----------QA EIQALHLLHSTRMLPxA-xEP---ALA---------------------CT HL----------------------------------LSPSS--------- -------------------------------------------------- -----------------LLRSQSLSSLLSVPS------------------ -------------------------------------------------- -ALSVLHNL-----------------------------------ALKCVL H------------------------------------------------- -------------------------------------------------- -----GRVSE----------GVEHY------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ----------------------------------------LDL------- -------------------------------------------------- -------------------------------------------------- ---------------LAAFH-SED-------------------------- -------------------------------------------------- --------------------------xQ---------------------- -------------------------------------------------- ------------------------------------------x------- -----HAEVPP-LPRLTELYLEAGTALLMAQRPADC-------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ----------------------------------------MALCD----- -------------------------------------------------- -------------------------------------------------- -------EVISTTLEL-----LPEKLILE--------------------- ------ELEQRx--x----------------------------------- -------------------------------------------------- -------------------------------xxxxxxxx----------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- E------------------------------------------------- -----------------------------------------DRVA----- ---------MLLWTGA---------------------------------- -------------------------------------------------- -------------------------------------------------- ----AYLLQGHCQTHL--KDWKQAVIHYTRCINLLMKVxxx--------- --------------------------------KR---------------G -----------------------------------------xxxxxxx-- --------A-------xx-xxxxx-------------------------- ------------TYL-----------------xV---------------- -----------------------LQKL----------------------- -------------------------------------------------- ----KGLSLAGRGISFTQT------------------------------- ---------------------------DQLKEALRDLQLSL--------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- --QAFP-------------------------------------------- --------------------ECVGAGLW---------------------- -----------------------------CGEVLWRL------------- -------------------------------------------------- --GRRRMAAAH---------------------W----------------- -------EKTWTFS-----AQ-x-------xx------------------ -----xS-----------------------------------------LP VYLQEx-------------------------------------------- -------------------------------------------xxx-PSL DSTELRHR----------------------------------------IQ EL------------------------------------------------ ------------------------------xx-x---------------- -------- >ENSMAMP00000020344 x------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ----xxxx----------------------------------------xx xxW---------------------------------------------CS SEFNKLLRKI---------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ---------------------Q---------------------------- ------GxL-----------------------LFI--------------- --xVPPLADYTQ-------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- --------------------------------------------LELSVV YNACLCLTA--QSQxxxxxx--LLTQATER-------------------- --------------VLQMHG-DDH---VAx--HPHVF------------- --WRTI-------------------------------------------- -------------------------------------------------F KSIG-NTSLNSRVLYLVC-------------------------------- -------------------------------------------------- -------------------------------------VQW---------- -----------------------------------------------AMW LATCQLKIIEEFx------------------------------------- -------------------------------------xx----------- -------------------------------------------------- -------------------------xxxxxxxxx---------------- -------------------------------------------------- xxxxxxxxxxxxxSDLPLLVTDPRRLVQLLQ------------------- ------------------------I--------------------CTFIA QGA--------EKLNEGHS----------------SQALSAMQKASCLPS PRAL------------------------------VAYTHLLSGSCFAHMS -------------------------------------------------- ----------------RCQMAL-----QCYRKALETDSRCVCALYQ---- -------------------------------------------------- ---------------------------SVLIYRQLGNT----------QA EIQALRLLHSTLMLPxA-xEP---VLA---------------------ST HL----------------------------------LSPSL--------- -------------------------------------------------- -----------------LLSSQSLSSLLSVPS------------------ -------------------------------------------------- -ALSVLHSL-----------------------------------ALTCVL H------------------------------------------------- -------------------------------------------------- -----GRASE----------GVEHY------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ----------------------------------------LDL------- -------------------------------------------------- -------------------------------------------------- ---------------LAALH-SED-------------------------- -------------------------------------------------- -------------------------QHGx--------------------- -------------------------------------------------- ----------------------xFRTLTNISVxxxx-----xx------- -----HAEVPL-LPRLPELYLEAGTALLMSQRPADC-------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ----------------------------------------MVLCD----- -------------------------------------------------- -------------------------------------------------- -------EVISTTLEL-----LPEKVLLG--------------------- ------ELDERxxxx----------------------------------- -------------------------------------------------- -------------------------------xxxxxxxx----------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- E------------------------------------------------- -----------------------------------------DRIQ----- ---------MLLWTGA---------------------------------- -------------------------------------------------- -------------------------------------------------- ----AYLLQGHSHTHL--KDWKQAVSHYTRSINLLMKVxxx--------- --------------------------------K----------------- -------------------------------------------------- --------x-------xx-xxxxx-------------------------- ------------TYL-----------------xV---------------- -----------------------LQKL----------------------- -------------------------------------------------- ----KGLSLAGRGVSFTQT------------------------------- ---------------------------DQLKEALRDLQLSL--------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- --QAFP-------------------------------------------- --------------------ECVAAGLW---------------------- -----------------------------CGEVLWRL------------- -------------------------------------------------- --GRKCEAAAI---------------------W----------------- -------EKTWTFN-----RQ-x-------xx------------------ -----xS-----------------------------------------LP LYLQEx-------------------------------------------- -------------------------------------------xxx-PLL DTTELRHR----------------------------------------IQ EL------------------------------------------------ ------------------------------xx-x---------------- -------- >ENSKMAP00000018287 -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ----------x-----------x--------------------------- -------------------------------------------------x xxS-------------LLDKWVQENNELANNFK-------xx------x- ---------------------xxxxxx----------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- SEFHKLLRKI---------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ---------------------Q---------------------------- ------G------------------------------------------- ---IPPDAGHAE-------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- --------------------------------------------LELSVV YNASVCFIA--QSQxxxxxx--LLQQATER-------------------- --------------VLQMTG-DDP---DTx--DPLVL------------- --WRTV-------------------------------------------- -------------------------------------------------L KSVR-KTAFHHHVLYLLS-------------------------------- -------------------------------------------------- -------------------------------------LQW---------- -----------------------------------------------AIW LTNSYLKTIRDFx------------------------------------- ------------------------------------xxx----------- -------------------------------------------------- -------------------------xxxxxxxxx---------------- -------------------------------------------------- xxxxxxxxxxxxxPDVPKLITDPRRLVELLQ------------------- ------------------------I--------------------CTIIT QGA--------ERLSEGWS----------------SEVLSDLQAASTLPA ARAL------------------------------VAYTHLLSGACLAHMN -------------------------------------------------- ----------------RPQMAL-----QCYKTALETDSHCVCALYQ---- -------------------------------------------------- ---------------------------SILIYRQLKNS----------QA EIQTLRILHSILLLPxS-xEP---AMA---------------------GT HL----------------------------------LSPSL--------- -------------------------------------------------- -----------------FLRSQSLSSLLSVPS------------------ -------------------------------------------------- -ALSVLHSL-----------------------------------ALKCVL H------------------------------------------------- -------------------------------------------------- -----SRASE----------GVEHY------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ----------------------------------------LDL------- -------------------------------------------------- -------------------------------------------------- ---------------LAALH-SED-------------------------- -------------------------------------------------- -------------------------QHR---------------------- -------------------------------------------------- -----------------------------------x-----xV------- -----HAEVST-LPKLPRLYLEAGAALLMAQRPADC-------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ----------------------------------------MALCS----- -------------------------------------------------- -------------------------------------------------- -------EVISTTQDL-----LPQKVVLD--------------------- ------E-xxxxxxx----------------------------------- -------------------------------------------------- -------------------------------xxxxxxxx----------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- E------------------------------------------------- -----------------------------------------GGLA----- ---------MFLWTAA---------------------------------- -------------------------------------------------- -------------------------------------------------- ----AYLLQGHCFTHM--KDWKQAVTHYTRCINLLVKVxxx--------- --------------------------------Nx---------------- -------------------------------------------------- ----------------xx-xxxxx-------------------------- ------------GDF-----------------xI---------------- -----------------------LQRL----------------------- -------------------------------------------------- ----KGLSFAGRGISFTQM------------------------------- ---------------------------DRMKEALRDLQHSL--------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- --QVLP-------------------------------------------- --------------------EGVGAGLW---------------------- -----------------------------CGEVLWRL------------- -------------------------------------------------- --SRRCDAAAC---------------------W----------------- -------EKTWSLP-----TQ-x-------xx------------------ -----xT-----------------------------------------LP VYVQEx-------------------------------------------- -------------------------------------------xxx-PLL DSTELRHR----------------------------------------LH EL------------------------------------------------ ------------------------------xx-x---------------- -------- >ENSFHEP00000009953 -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ----------x-----------x--------------------------- -------------------------------------------------- --S-------------LLAKWTRENNELAFNCKxQN---xxx------xx x--------------xxxxxxx---------------------------- -------------------------------------------------- -------------------------------------------------- -RR---------------------------------------------CS SDFHKLLRKL---------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ---------------------Q---------------------------- ------G------------------------------------------- ---IPPHSDHAQ-------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- --------------------------------------------LELSVV YNACVCLTA--LSHxxxxxx--LLTQAAHR-------------------- --------------VLELAG-EDR---GTx--DPSVL------------- --WRAA-------------------------------------------- -------------------------------------------------L KSVA-GTALHRHVLSLLC-------------------------------- -------------------------------------------------- -------------------------------------LQW---------- -----------------------------------------------GIW LAKSCLNPIKEFx------------------------------------- -----------------------------------xxx------------ -------------------------------------------------- -------------------------xxxxxxxxx---------------- -------------------------------------------------- xxxxxxxxxxxxxPNIPRLVLDPRRLAELLK------------------- ------------------------I--------------------CTAIV QGA--------ERLNEGWx------------------TLSALQAAAALPA PRAL------------------------------IAYTHLLSGSCLAHMN -------------------------------------------------- ----------------RPQMAL-----QCFRRALETDPRCACALYQ---- -------------------------------------------------- ---------------------------STLLYRQLGNV----------QA EIQALRILHSTLLLPxT-xEP---APA---------------------AG RL----------------------------------LSPSL--------- -------------------------------------------------- -----------------FLCSQSLGSLLSVPS------------------ -------------------------------------------------- -ALSVLHSL-----------------------------------ALKCVI H------------------------------------------------- -------------------------------------------------- -----DRVSE----------GVENY------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ----------------------------------------LDL------- -------------------------------------------------- -------------------------------------------------- ---------------LAALR-SED-------------------------- -------------------------------------------------- -------------------------QHG---------------------- -------------------------------------------------- -----------------------------------xxxxxxxA------- -----HAVVST-LPKLPRLYLEAAAALLMARRPADC-------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ----------------------------------------MALCD----- -------------------------------------------------- -------------------------------------------------- -------EVIGTILDL-----LPDKVLLE--------------------- ------DPEDxxxxx----------------------------------- -------------------------------------------------- -------------------------------xxxxxxxx----------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- E------------------------------------------------- -----------------------------------------SGLV----- ---------KLLWAAA---------------------------------- -------------------------------------------------- -------------------------------------------------- ----AYLLLGHCYAQQ--EDWKQAVTHYTRCFNLLVKVxxx--------- --------------------------------NN---------------x -----------------------------------------xxxxxxx-- --------P-------xx-xxxxx-------------------------- ------------VDL-----------------xV---------------- -----------------------LQRL----------------------- -------------------------------------------------- ----KGISLAGRGISFAQM------------------------------- ---------------------------DRLREALRDLHLGL--------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- --QALP-------------------------------------------- --------------------EGVSAGQW---------------------- -----------------------------CGEVLWRL------------- -------------------------------------------------- --DRRREAAAC---------------------W----------------- -------EKTWSHT-----CP-x-------xx------------------ -----xA-----------------------------------------LP VYAQEx-------------------------------------------- -------------------------------------------xxx-PLL DPTELRSR----------------------------------------LK EL------------------------------------------------ ------------------------------xx-x---------------- -------- >ENSXCOP00000022616 -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ----------x-----------x--------------------------- -------------------------------------------------x xxS-------------LLESWTQENNQLASSCK----------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ----------------------x-xxxxxxxxxxxxx------------- -----xG------------------------------------------- ---IPPHLDRAQ-------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- --------------------------------------------LELSVA YNTCVCFTA--QSQxxxxxx--LLTQSAQR-------------------- --------------LLQIAG-DDP---GTx--DPSVL------------- --WRAA-------------------------------------------- -------------------------------------------------L KSVT-GTALRRYVLNLLC-------------------------------- -------------------------------------------------- -------------------------------------VQW---------- -----------------------------------------------GVW LAKSRLNAMQDFx------------------------------------- ------------------------------------xx------------ -------------------------------------------------- -------------------------xxxxxxxxx---------------- -------------------------------------------------- xxxxxxxxxxxxxPNxPILVLDPRRLVDLLK------------------- ------------------------I--------------------CTTIV QGA--------ERLTEGWx------------------VLSALQAASASPA PRAL------------------------------IAYTHLLSGSCLAHMN -------------------------------------------------- ----------------RPQMAL-----QCYRKALEADPRCVCALYQ---- -------------------------------------------------- ---------------------------SALIYRRLENL----------QA EVQALRILHSILLLPxS-xEP---AMA---------------------AG RL----------------------------------LSPSL--------- -------------------------------------------------- -----------------FLCSQSLSSLLSVPS------------------ -------------------------------------------------- -ALSVLHSL-----------------------------------ALKCVI H------------------------------------------------- -------------------------------------------------- -----GRVSE----------GVECY------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ----------------------------------------LDL------- -------------------------------------------------- -------------------------------------------------- ---------------LAALQ-SED-------------------------- -------------------------------------------------- -------------------------QHG---------------------- -------------------------------------------------- -----------------------------------x-----xV------- -----HAAVST-LPKLPRLYLEAGAALVMAQRPADC-------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ----------------------------------------MALCD----- -------------------------------------------------- -------------------------------------------------- -------EVIGSTLDL-----LPEKVLLE--------------------- ------DPGDGxxxx----------------------------------- -------------------------------------------------- -------------------------------xxxxxxxx----------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- E------------------------------------------------- -----------------------------------------NGLV----- ---------RLLWTAA---------------------------------- -------------------------------------------------- -------------------------------------------------- ----AYLLQGHCYSQL--KDWKQAVTHYTRCINLLVKVxxx--------- --------------------------------DT---------------- -------------------------------------------------- ----------------xx-xxxxx-------------------------- ------------VDL-----------------xV---------------- -----------------------LQRL----------------------- -------------------------------------------------- ----KGLSLAGRGISFAQI------------------------------- ---------------------------DRLKESLRDLHLSQ--------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- --QAHP-------------------------------------------- --------------------EGVSARRW---------------------- -----------------------------YGEVLWRL------------- -------------------------------------------------- --DRKQEAAAC---------------------W----------------- -------EQTWSHP-----xP-x-------xxx--xxxxxxxW-----xx xx-xxxA-----------------------------------------LP VYAQEx-------------------------------------------- -------------------------------------------xxx-PVL DSAKLQQK----------------------------------------LQ EP------------------------------------------------ ------------------------------xx-x---------------- -------- >ENSPLAP00000020315 -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ----------x-----------x--------------------------- -------------------------------------------------x xTS-------------LLESWTQENNQLASGCKxQD-xxxxx------xx x--------------x-xxxxx---------------------------- -------------------------------------------------- -------------------------------------------------- -xx---------------------------------------------xS SDFHRLLRKI---------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ---------------------Q---------------------------- ------G------------------------------------------- ---IPPHLDRAQ-------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- --------------------------------------------LELSVV YNTCVCFTA--QSQxxxxxx--LLTQTAQR-------------------- --------------LLQIAG-DDP---GTx--DPSVL------------- --WRTA-------------------------------------------- -------------------------------------------------L KSVT-GTALHRRVLSLLC-------------------------------- -------------------------------------------------- -------------------------------------LQW---------- -----------------------------------------------GVW LAKSRLTAVQDFx------------------------------------- -----------------------------------xxx------------ -------------------------------------------------- -------------------------xxxxxxxxx---------------- -------------------------------------------------- xxxxxxxxxxxxxSNIPILVLDPRRLVDLLK------------------- ------------------------I--------------------CTAIV QGA--------ERLTEGWx------------------VLSALQAASASPA PRAL------------------------------IAYTHLLSGSCLAHMN -------------------------------------------------- ----------------RPQMAL-----QCYRKALETDPRCVCALYQ---- -------------------------------------------------- ---------------------------SALIYSRLENS----------QA EIQALRILHSMLLLPxT-xEP---AMA---------------------AD RL----------------------------------LSPSL--------- -------------------------------------------------- -----------------FLCSQSLSSLLSVPS------------------ -------------------------------------------------- -ALSVLHSL-----------------------------------ALKCVI H------------------------------------------------- -------------------------------------------------- -----SRVSE----------GVECY------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ----------------------------------------LDL------- -------------------------------------------------- -------------------------------------------------- ---------------LAALQ-SED-------------------------- -------------------------------------------------- -------------------------QHG---------------------- -------------------------------------------------- ------------------------------------------x------- -----HAAVST-LPKLPRLYLEAGAALLMARRPADC-------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ----------------------------------------MALCD----- -------------------------------------------------- -------------------------------------------------- -------EVIGSTLDL-----LPEKVLLE--------------------- ------DPVARxxxx----------------------------------- -------------------------------------------------- -------------------------------xxxxxxxx----------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- E------------------------------------------------- -----------------------------------------NGLV----- ---------RLLWTAA---------------------------------- -------------------------------------------------- -------------------------------------------------- ----AYLLQGHCYSQL--KDWKQAVTHYTRCINLLVKVxxx--------- --------------------------------DT---------------x -----------------------------------------xxxxxxx-- --------A-------xx-xxxxx-------------------------- ------------VDL-----------------xV---------------- -----------------------LQRL----------------------- -------------------------------------------------- ----KGLSLAGRGISFAQI------------------------------- ---------------------------DRLREALRDLQLSR--------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- --QAHP-------------------------------------------- --------------------EGVSARRW---------------------- -----------------------------YGEVLWRL------------- -------------------------------------------------- --DRKQEAAAC---------------------W----------------- -------EQTWSNP-----IP-x-------xx------------------ -----xA-----------------------------------------LP VYAQEx-------------------------------------------- -------------------------------------------xxx-PLL DSAELRQK----------------------------------------LQ EL------------------------------------------------ ------------------------------xx-x---------------- -------- >ENSPMEP00000025174 -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ----------x-----------x--------------------------- -------------------------------------------------x xxS-------------LLESWTQENNQLASGCK--x-xxxxx------xx x--------------x-xxxxx---------------------------- -------------------------------------------------- -------------------------------------------------- -RR---------------------------------------------WS SDFHKLLRKI---------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ---------------------Q---------------------------- ------G------------------------------------------- ---IPPHLDRAQ-------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- --------------------------------------------LELSVV YNTCVCFTA--QSQxxxxxx--LLTQTAQR-------------------- --------------LLQIAG-DDP---GTx--DPSVL------------- --WRTA-------------------------------------------- -------------------------------------------------L KSVT-GTALHRRVLSLLC-------------------------------- -------------------------------------------------- -------------------------------------LQW---------- -----------------------------------------------GVW LAKSRLTAVQDFx------------------------------------- -----------------------------------xxx------------ -------------------------------------------------- -------------------------xxxxxxxxx---------------- -------------------------------------------------- xxxxxxxxxxxxxSNIPILVLDPRRLVDLLK------------------- ------------------------I--------------------CTAIV QGA--------ERLTEGWx------------------VLSALQAASASPA PRAL------------------------------IAYTHLLSGSCLAHMN -------------------------------------------------- ----------------RPQMAL-----QCYRKALETDPRCVCALYQ---- -------------------------------------------------- ---------------------------SALIYSRLENS----------QA EIQALRILHSMLLLPxT-xEP---AMA---------------------AG RL----------------------------------LSPSL--------- -------------------------------------------------- -----------------FLCSQSLSSLLSVPS------------------ -------------------------------------------------- -ALSVLHSL-----------------------------------ALKCVI H------------------------------------------------- -------------------------------------------------- -----SRVSE----------GVECY------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ----------------------------------------LDL------- -------------------------------------------------- -------------------------------------------------- ---------------LAALQ-SED-------------------------- -------------------------------------------------- -------------------------QHG---------------------- -------------------------------------------------- ------------------------------------------x------- -----HAVVST-LPKLPRLYLEAGAALLMARRPADC-------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ----------------------------------------MALCD----- -------------------------------------------------- -------------------------------------------------- -------EVIGSTLDL-----LPEKVLLE--------------------- ------DPVARxxxx----------------------------------- -------------------------------------------------- -------------------------------xxxxxxxx----------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- E------------------------------------------------- -----------------------------------------NGLV----- ---------RLLWTAA---------------------------------- -------------------------------------------------- -------------------------------------------------- ----AYLLQGHCYSQL--KDWKQAVTHYTRCINLLVKVxxx--------- --------------------------------DT---------------x -----------------------------------------xxxxxxx-- --------A-------xx-xxxxx-------------------------- ------------VDL-----------------xV---------------- -----------------------LQRL----------------------- -------------------------------------------------- ----KGLSLAGRGISFAQI------------------------------- ---------------------------DRLREALRDLQLSR--------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- --QAHP-------------------------------------------- --------------------EGVSARRW---------------------- -----------------------------YGEVLWRL------------- -------------------------------------------------- --DRKQEAAAC---------------------W----------------- -------EQTWSNP-----IP-x-------xx------------------ -----xA-----------------------------------------LP VYAQEx-------------------------------------------- -------------------------------------------xxx-PLL DSAELHQK----------------------------------------LQ EL------------------------------------------------ ------------------------------xx-x---------------- -------- >ENSPFOP00000016681 -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ----------x-----------x--------------------------- -------------------------------------------------x xTS-------------LLESWTQENNQLASGCK--x-xxxxx------xx x--------------x-xxxxx---------------------------- -------------------------------------------------- -------------------------------------------------- -xR---------------------------------------------WS SDFHRLLRKI---------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ---------------------Q---------------------------- ------G------------------------------------------- ---IPPHLDRAQ-------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- --------------------------------------------LELSVV YNTCVCFTA--QSQxxxxxx--LLTQTAQR-------------------- --------------LLQIAG-DDP---GTx--DPSVL------------- --WRTA-------------------------------------------- -------------------------------------------------L KSVT-GTALHRRVLSLLC-------------------------------- -------------------------------------------------- -------------------------------------LQW---------- -----------------------------------------------GVW LAKSRLTAVQDFx------------------------------------- -----------------------------------xxx------------ -------------------------------------------------- -------------------------xxxxxxxxx---------------- -------------------------------------------------- xxxxxxxxxxxxxSNIPILVLDPRRLVDLLK------------------- ------------------------I--------------------CTAIV QGA--------ERLTEGWx------------------VLSALQAASASPA PRAL------------------------------IAYTHLLSGSCLAHMN -------------------------------------------------- ----------------RPQMAL-----QCYRKALETDPRCVCALYQ---- -------------------------------------------------- ---------------------------SALIYSRLENS----------QA EIQALRILHSMLLLPxT-xEP---AMA---------------------AD RL----------------------------------LSPSL--------- -------------------------------------------------- -----------------FLCSQSLSSLLSVPS------------------ -------------------------------------------------- -ALSVLHSL-----------------------------------ALKCVI H------------------------------------------------- -------------------------------------------------- -----SRVSE----------GVECY------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ----------------------------------------LDL------- -------------------------------------------------- -------------------------------------------------- ---------------LAALQ-SED-------------------------- -------------------------------------------------- -------------------------QHG---------------------- -------------------------------------------------- ------------------------------------------x------- -----HAVVST-LPKLPRLYLEAGAALLMARRPADC-------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ----------------------------------------MALCD----- -------------------------------------------------- -------------------------------------------------- -------EVIGSTLDL-----LPEKVLLE--------------------- ------DPVARxxxx----------------------------------- -------------------------------------------------- -------------------------------xxxxxxxx----------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- E------------------------------------------------- -----------------------------------------NGLV----- ---------RLLWTAA---------------------------------- -------------------------------------------------- -------------------------------------------------- ----AYLLQGHCYSQL--KDWKQAVTHYTRCINLLVKVxxx--------- --------------------------------DT---------------x -----------------------------------------xxxxxxx-- --------A-------xx-xxxxx-------------------------- ------------VDL-----------------xV---------------- -----------------------LQRL----------------------- -------------------------------------------------- ----KGLSLAGRGISFAQI------------------------------- ---------------------------DRLREALRDLQLSR--------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- --QAHP-------------------------------------------- --------------------EGVSARRW---------------------- -----------------------------YGEVLWRL------------- -------------------------------------------------- --DRKQEAAAC---------------------W----------------- -------EQTWSNx-----xP-x-------xx------------------ -----xA-----------------------------------------LP VYAQEx-------------------------------------------- -------------------------------------------xxx-PLL DSAELRQK----------------------------------------LQ EL------------------------------------------------ ------------------------------xx-x---------------- -------- >ENSXMAP00000007520 -------------------------------------------------- -------------------------------------------------- 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-------------------------------------------------- -------------------------------------------------- -------------------------------------------------- --------------------------------------------LELSVA YNTCVCFTA--QSQxxxxxx--LLTQSAQR-------------------- --------------LLQIAG-DDP---GTx--DPSVL------------- --WREA-------------------------------------------- -------------------------------------------------L KSVT-GAALRRDVLNLLC-------------------------------- -------------------------------------------------- -------------------------------------LQW---------- -----------------------------------------------GVW LAKSRLNAMQDFx------------------------------------- -----------------------------------xxx------------ -------------------------------------------------- -------------------------xxxxxxxxx---------------- -------------------------------------------------- xxxxxxxxxxxxxPNIPILVLDPRRLVDLLK------------------- ------------------------I--------------------CTTIV 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--------------------------------------------LELSVV YNACLCSVA--CAQxxxxxx--LLKKATER-------------------- --------------VLQMTG-DDP---LDx--DPLLF------------- --WRTI-------------------------------------------- -------------------------------------------------I KSVE-NTAMKSSVQYIFG-------------------------------- -------------------------------------------------- -------------------------------------LQW---------- -----------------------------------------------AIW LADCKLTTIQECx------------------------------------- -----------------------------------xxxx----------- -------------------------------------------------- -------------------------xxxxxxxxx---------------- -------------------------------------------------- x--xxxxxxxxxxCDVPRLVMDPGRLLKLLQ------------------- ------------------------I--------------------CTLIT QGA--------ERLSEGRS----------------SEALSGLQTASSLPA PTTL------------------------------VAYTHLISGSCLALMN -------------------------------------------------- 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