>CDKL5_1_of_2_ORYLA PROTID=ENSORLP00000020490 TRANSID=ENSORLT00000020491 GENEID=ENSORLG00000016364 TAXID=8090
-------------------------------------------------------NLKKHI---------
-----------------------------------------------K---QEFRSKEDTNEIVAIKKFK
DSEENEEVKETTLRELKMLRTLKQENIVELKEAFRRRGKLYLVFEYVEKNMLELLEELPTGVPTEKVRSY
IFQLIKAIHWCHKHDIVHRDIKPE-------NLLISSADVLKLCDFG--FARNLSEGTDANYTEYVATRW
YRSPELLLGAPYGKAVDMWSVGCILGELSDGQPLFPGESELDQLFTIQKVLGPLPPEQMKLFYNNPRFHG
LRFPAVNHPQTLERRYLGIIGVGLLDLLKNLLLLNPTERFLTEQCLNHHTFQTLRLV--ER-AGP-----
PTPTPARSSKRKP-HH-GDNNTPS-----R----SHGGKSS---GGH-RSSSRECSSLP----RHEDV-H
SSNDAFLNG-NMSAVMNLSPTLHPKN-YQPQIFNHSTACSMDLASSNLPHLHSSSEAKSKGDFEMNLG--
SKVSD-GPGA----------KY--LK-SNFR---SQQ---------------------------------
-----------NRH-SFVE---GKTSTLQSG-EK-HSRHNY-ME--SHSSMP--SSSKF--AYLNLSKSY
GTLSDAKSVGNLNDLHLYADEPT--S----------RYFPSSCLDLTAPS-------SP-ASRR--VE-R
LGLGTG---GRGSMR----S---D-R-ESNTLDSSYRRSSTRH-KS--SEEAKSP-DSLDAGEGST--ER
SHAHSLSAPHDPQVYGQGYTSPFSSQQRPHRHSMYVRRDHQRTHGADDGLS----VGQGLATRASSLQLL
SPQLQHR-TLPRHSGSSSRE---EDMSR-----------------------S-EQAST-EVT----HSRP
AIRDSTRDNTASFHTQRQKSE--------------------------------VGLYHDQQAEDGGSSKE
NRNIYSESMPRRVGSFYR---------------------------------------VPSPRPDN--AFH
ESRAQSRP---SALSGDGSSLTNHTKRQPAFDPW-----TGPDTVVL--NASEPSKEKGKQGFFRAIKKK
KKKPQM----------------------------------------------------------------
----------------------------------------------------------------------
-----------AANE-GMD--SAIQKSSRSSGHQS------SRH----RSRDKSRDRNQDRDRD--K---
--------------------------------DWPPEKPSDSHS--------------------------
--------P--------RDVPRLLQSQPLKSLRKLLHL-SSSSSNQT--------ASS-D----MRYQ-P
LTN----STQG-GFAE------NRGHSGV-----ST----------------------PQLKSRQT-GYP
LP------------------------------------------------------G-------------
----------------------------------------------------------------------
----------------------------------------------------------------------
-----------------------------------------------QLESGWHSSALGR--PEGNPY-P
EQMGIKGGQNGHGFGRPSRSRMPNLNDLKETAL-------------------------------------
-----------
>CDKL5_1_of_2_ORENI PROTID=ENSONIP00000003962 TRANSID=ENSONIT00000003963 GENEID=ENSONIG00000003161 TAXID=8128
--------------------------FMISKIGDVLNMIHVMTILLELFAGLLILILKTKM---------
-----------------------------------------------K----------DTNEIVAIKKFK
DSEENEEVKETTLRELKMLRTLKQENIVELKEAFRRRGKLYLVFEYVEKNMLELLEELPNGVPSEKARSY
IFQLIKAIHWCHKHDIVHRDIKPE-------NLLISSDDVLKLCDFG--FARNLSEGTDANYTEYVATRW
YRSPELLLGAPYGKAVDMWSVGCILGELSDGQPLFPGESEIDQLFTIQKVLGPLPPEQMKLFYNNPRFHG
LRFPTVSHPQTLERRYLGIIDAALLDLLKNMLLLNPTERFLTEQSLNHHAFQTLRMV--ER-PGP-----
PTPTPVRSSKRKP-HH-GDNTTPS-----R----SHGGKSS---GSH-RSSSRECSSLP----RHEDL-H
PNNDSFLNG-NMSAAINLSPTLHPKN-YQPQIFNHSTACSMDLASSNLPHLLSPGETKSKGDFEMNLG--
SKVSD-GPGA----------KY--LK-SNFR---SQQ---------------------------------
-----------NRH-SFVE---GKTNTLQSG-DK-HSRHNY-ME--AHSSTP--SSSKF--AYLNLSKSY
GTLSDAKSVGNLNDVHLYADEPT--S----------RYFPSSCLDLTAPG-------SP-AARR--VE-R
LGPGTG---GRGSMR----S---E-R-ESNTLDSSYRRSSTRH-KT--SEESKSP-DSLDPGE--S--ER
SHSHSLSAPHDPLSYGQGYTSPFSSQQRPHRHSMYVRRDHQRTHGGDEGLL----VGQGIPTRASSLQLL
SPQLQHR-TLPRHSGGSSRE---EDMSR-----------------------N-EQAPT-EVT----HSRP
PIRDSTRDNTASFHTQRKKSE--------------------------------VGLYHDQQTEDGGSSKE
NRNIYSESMPRRVGSFYR---------------------------------------VPSPRPDN--SFH
DSRGQGRG---SGLSGDGGSLANHSKRQPAFDPW-----TGPDTVVL--NASEPSKEKEKQGFFRAIKKK
KKKSQM----------------------------------------------------------------
----------------------------------------------------------------------
-----------VSGE-GVD--TVIQKSSRSSSHQS------NRH----RSRDKSRDRDQDRDRD--K---
--------------------------------DWPPEKLSDSHS--------------------------
--------S----------------SQPLKSLRKLLHL-SSSSSNQT--------ASS-D----MRYQ-P
LPNS--ASAQG-GFTE------SRGHSGV-----ST----------------------PQLKARQS-AYP
LP------------------------------------------------------G-------------
----------------------------------------------------------------------
----------------------------------------------------------------------
-----------------------------------------------QLDSGWHTSALGR--PEGNPY-P
EQMSIKGGQNGHGFGRPSRSRMPNLNDLKETAL-------------------------------------
-----------
>CDKL5_1_of_2_TAKRU PROTID=ENSTRUP00000031949 TRANSID=ENSTRUT00000032072 GENEID=ENSTRUG00000012621 TAXID=31033
MKNPNIGDVMNKFEVLGIVGEGAYGV-----------------------------VLKCRH---------
-----------------------------------------------K----------ETNEIVAIKKFK
DSEENEEVKETTLRELKMLRTLKQENIVELKEAFRRRGKLYLVFEYVEKNMLELLEELPNGVPTDKARSY
IYQLIRAIHWCHKHDIVHRDIKPE-------NLLISSDDVLKLCDFG--FARSLSEGTDANYTEYVATRW
YRSPELLLGAPYGKAVDMWSVGCILGELSDGQPLFPGESEIDQLFTIQKVLGPLPSEQMKLFYNNPRFHG
LRFPAVNHHQTLERRYLGIIGGGLLDLLKNLLLLNPTERFLTEQCLNHHAFQTLRLV--ER-SGP-----
PTPTPVRSSKRKP-HH-GDNTTPS-----RS---SHGGKSS---GGH-RSSSRECSSLP----RHEDL-H
PNTEGFLNG-SITAAINLSPTLHPKN-YQPQIYNHSTSCSMDLASSNLPHLLSPGEAKSKCDFDLNLG--
SKVPD-GPGA----------KY--LN-SNFR---SQQ---------------------------------
-----------NRH-SFVE---GKTSTLQSG-DK-HSRHAY-ME--AHSSTP---SAKF--AYLNLSKSY
GTLSDAKSVGNLNDVHLYADEPT--S----------RYFPSSCLDLTAPS-------SP-AARR--MD-R
LGL------GR---R-RRWR---Q-R-ESNTLDSSHRRSSIRL-KA--SEEAKSP-DGLDPGD--SGIER
SHAHSLSSPRDPLSYGQGYTSPFSSQQRPHRHSMYVRRDHQRTHGAEEGLA----VGQGLPTRASSLQLL
SPQL-----------------------------------------------S-EQTPT-EVT----HSRP
PIRDSTRDNTASFHTQRQKSE--------------------------------VGLYHDQQTEDGGSSKE
NRNIYSESMPRRVGSFYR---------------------------------------VPSPRPDN--SFH
DSRGQSRD---SGLSSDGTRLTNHSKRQPGFDPW-----TGPDTVVL--NPSEPSKEKEKQGFFRAIKKK
KKKSQM----------------------------------------------------------------
----------------------------------------------------------------------
-----------VTS----------QKSSRSSGHQS------SRH----RTRSKSRDRDKERDQA--K---
--------------------------------DWPHEKLSDSHS--------------------------
--------P----------------SQPLKSLRKLLHL-TSSSSSQA--------APP-D----MHYQ-P
LPNP--ASAQG-GFTE------SRTH--------------------------------------------
----------------------------------------------------------------------
----------------------------------------------------------------------
----------------------------------------------------------------------
----------------------------------------------------------------------
----------------------------------------------------------------------
-----------
>CDKL5_1_of_2_TETNG PROTID=ENSTNIP00000009136 TRANSID=ENSTNIT00000009307 GENEID=ENSTNIG00000006372 TAXID=99883
MKNPDIGDVMNKFEVLGIVGEGAYGV-----------------------------VLKCRH---------
-----------------------------------------------K----------ETNEIVAIKKFK
DSEENEEVKETTLRELKMLRTLKQENIVELKEAFRRRGKLYLVFEYVEKNMLELLEELPNGVPTDKARSY
IYQLIRAIHWCHKHDIVHRDIKPE-------NLLISSDDVLKLCDFG--FARSLSEGTDANYTEYVATRW
YRSPELLLGAPYGKAVDMWSVGCILGELSDGQPLFPGESEIDQLFTIQKVLGPLPSEQMKLFYNNPRFHG
LRFPAVNHHQTLERRYLGIIGGGLLDLLKNLLLLTPTERFLTEQCLNHHAFQTLRLV--ER-SGP-----
PTPTPVRSSKRKP-HH-GDNTTPS-----RSPSRSHGGKSS---GGH-RSSSRECSSLP----RHEDL-H
PNNDAFLNG-SMTAAINLSPTLHPKN-YQPQVYNHSTSCSMDLASSNLPHLLSPGESKSKCDFDLNLG--
SKVPD-GPGA----------KY--LN-SNFR---SQQ---------------------------------
-----------NRH-SFVE---GKTNTLQSG-DK-HSRHGY-ME--AHSSMP---SSKF--AYLNLSKSY
GTLSDAKSVGNLNDVHLYADEPT--S----------RYFPSSCLDLTAPS-------SP-AARR--MD-R
LGL---VASGRGSTR----S---D-R-ESNTLDSSHRRSSIRL-KA--SEEAKSP-DGLDPGD--SGMER
SHAHSLSSPREPLAYSQGYTSPFSSQQRPHRHSMYVRRDHQRTHGAEEGLA----VGQGLPTRAKSLQLL
SPQL-----------------------------------------------S-EQTPT-EVT----HSRP
PIRDSTRDNTASFHTQRQNSE--------------------------------VGLYHDQQAEDGGSSKE
NRNIYSESMPRRVGSFYR---------------------------------------VPSPRPDN--SFH
DSRGQSRD---SGLSSDGSRLTNHSKRQPGFDPW-----TGPDTVVL--NPSEPSKEKEKQGFFRAIKKK
KKKSQM----------------------------------------------------------------
-------------------------------------FPAHLQPSYYPLDIAFINRFQTVRNNTTKAWNM
QIKLLCLLLCC---------------------HQSLNNDAI-----------------------------
----------------------------------------------------------------------
----------------------------------LLHL-TSSSSSPA--------APP-D----MHYQ-P
LPTP--ASAQG-AFTE------SRTH--------------------------------------------
----------------------------------------------------------------------
----------------------------------------------------------------------
----------------------------------------------------------------------
----------------------------------------------------------------------
----------------------------------------------------------------------
-----------
>CDKL5_2_of_2_GASAC PROTID=ENSGACP00000019906 TRANSID=ENSGACT00000019944 GENEID=ENSGACG00000015093 TAXID=69293
-------------------------------------------------------------IQQIDFSLL
NTTRVL--------------------LSS------------------Q----------ETNELVAIKKFK
DSEENEEVKETTLRELKMLRTLKQDNIVELKEAFRRRGKLYLVFEYVERNMLELLEELPNGAPPDKVRSY
IYQLIKAINWCHTNEIVHRDIKPE-------NLLISSEDVLKLCDFG--FARNLSEGTDANYTEYVATRW
YRSPELLLGAPYGKAVDMWSVGCILGELSDGQPLFPGESEIDQLFTIQKVLGPLPAEQMKLFYNNPRFHG
IRFPSVAHPQTLERRYQAILSSLMLDLMKSLLLLNQTERFLTEQSLNHPAFQPLRQA--ER-PPP-----
SSPNPPRSSKRKTHHH-GENTVPT-----R----SH-TKST----SR-RSNSKECSSLP----RHGDLHH
LGNKSFLNG-NKPAPPTLSPTLHPKAQYMSQTLNRSASSNKDLVNNNLPHLLSPKEPKGKTEFDFNLGPS
AKLADQGHVS----------KYGHSKPSSTR---C-----------------------------------
------------RH-TFLE---GKTNTLQSAADKQHGRHSHSMADSAHGSMS--SSSKSSASYLSLSKSH
SALSDAKSVGNLSDGRLHPEDPN--SNATAGMGPGARFFPASCLDLNTPSVPQGPPGSP-SARH--SD-R
SGH------SPAS-R----SSGNV-RMESSTLDSSSRHKS-RH-KPLASEEAGAP-ELLDPGG--AGMPS
T--HTLPSPHESYHYGLGYTSPFSSQQRPQRHSMYVRRERHRPHGNEAAMAGLPPPGQAIPTRASSLQML
SPQLQHRTTLTGHSVSSSREDCTDTMTR-----------------------S-EQSPK-DMS----HPCA
PIKDSTRDNSAAFHTQRSKNE--------------------------------VSMYHDPHMEDGGSSKE
NRMIFTESMPRRVGSFYR---------------------------------------VPSPRPDNSSSFH
DGVGQGRGPVVPVVPGDPVAMVNHSKRQTAFD-W-----SAAEKMVM--NPPEPPKEKEKQGFFRAIKKK
KKKTQI----------------------------------------------------------------
----------------------------------------------------------------------
-----------VSGN-GQEHLS-LQRSSKSSSHHG------SRRKNRERSRDRDREREQS----------
RDDWPQDKPVDSHSQ--------TKTNPQH----------------------------------------
---------QSLRHPLN--------SQPLKSLRRLLHL-SPSSSNQG------------D----MRFQAP
LPNPPQPPSKA-GYSEGRGHAESRGHAGV----SSS----------------------AQAKSRKA-SYP
LP------------------------------------------------------G-------------
----------------------------------------------------------------------
----------------------------------------------------------------------
-----------------------------------------------QIESSWHVSALQR--AEGAQFTP
EQLGIKPGQNGPTFTRASRSRMPNLNDLKETAL-------------------------------------
-----------
>CDKL5_2_of_2_ORYLA PROTID=ENSORLP00000004483 TRANSID=ENSORLT00000004484 GENEID=ENSORLG00000003597 TAXID=8090
----------------------------------------------------------------------
-----LFKSDCFLVIFCIWLGQHSQSLSS------------------Q----------ETNELVAIKKFK
DSEENEEVKETTLRELKMLRTLKQDNIVELKEAFRRRGKLYLVFEYVERNMLELLEEFPNGALPDKVRSY
IYQLIKAINWCHKNEIVHRDIKPE-------NLLISSNDVLKLCDFG--FARNLSEGTDANYTEYVATRW
YRSPELLLGAPYGKAVDMWSVGCILGELSDGQPLFPGESEIDQLFTIQKVLGPLPAEQMKLFYNNPRFHG
IRFPSVTHPQTLERRYQGILSGLLLDLMKSLLLLNPTERYLTEQSLNHPVFQPLRQAERER-TSL-----
SSPNPPCSSKRKTHHH-GENTVPT-----R----SH-NKSS----SR-HSNSKECSSLP----RHGDLHH
LSNESFLNG-NKPAPSSLSPTLHPKAQYMSQTLNRSVSSSKDLANNNLPHLLSPKEAKNKTEFDFNLGPS
PKLSDPGHGG----------KYGHSKPSSSRPPLG-----------------------------------
------------RH-NFLE---NKTNTLQSGAEKQHGRHGHSMADSAHGSMS--SSSKSSASYLSLSKSH
NALSDAKSVGNLSDGRLHVDDPN--SNTVAGVGPSARFFPTSCLDLNSPSGPPGPPGSP-SARH--SE-R
AGH------SPAS-R----SSGNA-RMESSTLDSSSRHKS-RH-KSLAPDNAGGP-DLLDAGG--AGMPV
T--HTLPSPHESYHYGLGYTSPFSSQQRPQRHSMYVRRERHRPHGIESGMAGLPPPGQAIPTRASSLQLL
SPQLQHRTTLTGHSVSSSREDCTEDLTR-----------------------S-EQPPK-DMS----HPCA
PIKDSARDNTAAFHTQLSKNE--------------------------------VSMYHDPH-EDGGSSKE
NRMIFTESMPRRVGSFYR---------------------------------------VPSPRPDNSSSFH
EGVGQGRGQVMPVVPGDQVAMANHSKRQTAFD-W-----TTAEAMVM--NPPEPTKEKEKQGFFRSMKKK
KKKTQI----------------------------------------------------------------
----------------------------------------------------------------------
-----------VTGN-GQEHLS-LQRSSKSSSHHN------SRRKNRERSRDRD--REQS----------
RD---RDR--DRDSQRLGPREKKKQINLQQ----------------------------------------
-------------------------SQPLKSLRRLLHL-SPSSSNQGQN---PPPPPP-D----MRFQGP
LPNPPQPSSKT-GYLESRGHGESRGHSGV----SSS----------------------SQAKNRKA-SYP
LP------------------------------------------------------G-------------
----------------------------------------------------------------------
----------------------------------------------------------------------
-----------------------------------------------QIESSWHVSALQR--ADGAQFTA
EQLGIKPGQNGPTFTRASRTRMPNLNDLKETAL-------------------------------------
-----------
>CDKL5_2_of_2_TETNG PROTID=ENSTNIP00000012375 TRANSID=ENSTNIT00000012566 GENEID=ENSTNIG00000009502 TAXID=99883
----------------------------------------------------------------------
-----------------------------------------------Q----------ETNELVAIKKFK
DSEENEEVKETTLRELKMLRTLKQDNIVELKEAFRRRGKLYLVFEYVERNMLELLEEHPTGAPPDKVRSY
IYQLIKAINWCHKNEIVHRDIKPE-------NLLISSDDILKLCDFG--FARNLSEGTDANYTEYVATRW
YRSPELLLGAPYGKAVDMWSVGCILGELSDGQPLFPGESEIDQLFTIQKVLGPLPAEQMKLFYNNPRFHG
IRFPSVTHPQTLERRYQGILSGLMLDLMKNLLLLNPTERYLTEQSLNHPAFQPLRQAERERPPPP-----
ASPNPPRSSKRKTHHH-GENTVPT-----R----SH-SKST----SR-RSNNKECSSLP----RHGDLHH
LGSKSFING-NKPLPSSLSPTLHAKSQYMSQTLNRSPSSSKDLANNNLPHLLSPKEVKGKTEFDFNLGPS
PKLPDQGHMA----------KYGHSKPSSSR---SHQQPQ-----------------------------Q
QPPQPQQQQAV-RH-TFLE---NKNNTLQSGAEKPHGRHTHSMADSAHGSMS--SSSKSSASYLSLSKSH
SALSDAKSVGNLSDGRLHPDDLN--QN-IAGVGPGARFFPASCLDLNAPAGPPGPPGSP-SARH--SD-R
SGH------SPAS-R----SSGNI-RMESSTLDSSSRHKS-RH-KSLVPEEAGAP-ELLDPGG--AAMPS
T--HTLPSPHESYHYGLGYTSPFSSQQRPQRHSMYVRRERHRPHGAEGGMTGLSAPGQAIPTRASSLQLL
SPQLQHRTTLTGHSVSSSREDCTEDLTR-----------------------S-EQSPK-DMG----H---
PNKDSARDNTAAFHTQRSKNE--------------------------------AAMYHDPHGEDGASSKE
NRMIFTESMPRRVGSFYR---------------------------------------VPSPRPDN-SSFH
DAVGQGRGQVGPVGPVDPVAMAGHSKRQPAFD-W-----TAAEAMVM--NPPEPVKEKEKQGFFRAIKKK
KKKTQI----------------------------------------------------------------
----------------------------------------------------------------------
-----------VPGN-GQEQLS-LQRSTKSSSHHS------SRRKNRERSRDRHREREQS----------
RE---RER--DRERERERGRE------RERVSDW-PEK--------------------------------
--------P----------------SQPLKSLRRLLHL-SPSSSNQGQQSPAPPAPPP-D----LRFQAP
LPNPPQPPSKA-GYPEARGHADSRAHSGV----SSS----------------------SQAKSRKA-SYP
IP------------------------------------------------------G-------------
----------------------------------------------------------------------
----------------------------------------------------------------------
-----------------------------------------------QIESSWHVSALQR--AEGAQFTP
EQLGI-PGQNGPTFTRASRTRIPNLNDLKETAL-------------------------------------
-----------
>Q9W6R6_TAKRU PROTID=ENSTRUP00000043692 TRANSID=ENSTRUT00000043838 GENEID=ENSTRUG00000017053 TAXID=31033
----------------------------------------------------------------------
-----------------------------MFNSGSSLKSKIRQVYNEK----------ETNELVAIKKFK
DSEENEEVKETTLRELKMLRTLKQDNIVELKEAFRRRGKLYLVFEYVERNMLELLEEHPTGAPPDKVRSY
IYQLIKAINWCHKNEIVHRDIKPE-------NLLISSDDILKLCDFGNCFARNLSEGTDANYTEYVATRW
YRSPELLLGAPYGKAVDMWSVGCILGELSDGQPLFPGESEIDQLFTIQKVLGPLPAEQMKLFYNNPRFHG
IRFPSVTHPQTLERRYQGILSGLMLDLMKNLLLLNPTERYLTEQSLNHPAFQPLRQVERERPAPP-----
ASPNPPRSSKRKTHHH-GENTVPT-----R----SH-SKST----SR-RSNSKECSSLP----RHGDLHH
LGSKSFLNG-NKPPPSSLSPTLHPKSQYMSQTLNRSPSSSKDLVNNNLPHLLSPKEVKGKTEFDFNLGPS
PKLPDQGHGA----------KYSHSKPSSSR---SQQQQQQLQQQQQQQLQQQQLQLQQQQQQLQQQQLQ
QQQQQQQQQAI-RH-TFLE---NKNNTLQSGAEKQHSRHTHSMADSAHGSMS--SSSKSSASYLSLSKSH
SALSDAKSVGNLSDGRLHPDDPN--SN-TAGLGPGARFFPTSCLDLNAPTGPPGPPGSP-SARH--SD-R
SGH------SPAS-R----SSGNI-RMESSTLDSSSRHKS-RH-KSSAPEEAGAP-ELLDPGG--AAMPS
T--HTLPSPHESYHYGLGYTSPFSSQQRPQRHSMYVRRERHRPHGVEGGMAGLPAPGQGIPMRASSLQLL
SPQLQHRTTLTGHSVSSSREDCTDDMTR-----------------------S-EQSPK-DMG----HPCA
PIKDSARDNTAAFHTQRSKNE--------------------------------AGLYHDPHGEDGASSKE
NRMIFTESMPRRVGSFYR---------------------------------------VPSPRPDNSSSFH
DAVGQGRVPVGPVVPVDPVAMVGHSKRQTAFD-W-----TAAEAMVM--NPLEPVKEKEKQGFFRAIKKK
KKKTQL----------------------------------------------------------------
----------------------------------------------------------------------
-----------VPGN-GQEHLS-LQRSTKSSSHHS------SRRKNRERSRDRHREREQSRDRD--RERE
RE---RER--DRERERERGRE------LER----------------------------------------
-------------------------SQPLKSLRRLLHL-SPSSSNQRQQSPASPAPPP-D----LRFQAP
LPNPPQPPSKA-GYPETRGHADSRGHSGV----SSS----------------------SQPKSRKA-SYP
IP------------------------------------------------------G-------------
----------------------------------------------------------------------
----------------------------------------------------------------------
-----------------------------------------------QIESSWHVSALQR--AEGAQFTP
EQLGIKPGQNGPTFTRASRTRIPNLNDLKETAL-------------------------------------
-----------
>CDKL5_2_of_2_ORENI PROTID=ENSONIP00000004315 TRANSID=ENSONIT00000004317 GENEID=ENSONIG00000003427 TAXID=8128
---------MNKFEVLGIVGEGAYGV-----------------------------VLKCRH---------
-----------------------------------------------K----------ETNELVAIKKFK
DSEENEEVKETTLRELKMLRTLKQDNIVELKEAFRRRGKLYLVFEYVERNMLELLEEMPNGAPPDKVRSY
IYQLIKAINWCHKNEIVHRDIKPE-------NLLISSEDVLKLCDFG--FARNLSEGTDANYTEYVATRW
YRSPELLLGAPYGKAVDMWSVGCILGELSDGQPLFPGESEIDQLFTIQKVLGPLPAEQMKLFYNNPRFHG
IRFPSVTHPQTLERRYQGILSGLMLDLMKNLLLLNPTERYLTEQSLNHPAFQPLRQAERER-PPP-----
ASPNPPRSSKRKTHHH-GENTVPT-----R----SH-TKSS----SR-RSNSKECSSLP----RHGDLHH
LGNESFLNG-NKPAPSSLSPTLHPKGQYMSQTLNRSISSSKDLVNNNLPHLLSPKEPKSKTEFDFNLGPS
PKLPDQGHGV----------KYGHGKPSSSR---SQQQQQ-----------------------------Q
QQQQQQ----VSRH-TFLE---NKTNTLQSGAEKQHSRHAHSMADSAHGSMS--SSSKSSASYLSLSKSH
SGLSDAKSVGNLSDGRLHPDDPN--SNTTAGVGPSARFFPASCLDLNTPSGPSGPPGSP-STRH--SD-R
SGH------SPAS-R----SSGNA-RMESSTLDSSSRHKS-RH-KSLVPEDAGAP-ELLDPGG--PGMPS
T--HTLPSPHESYHYGLGYTSPFSSQQRPQRHSMYVRRERHRPHGVETAMAGLPPPGQAIPTRASSLQLL
SPQLQHRTTLTGHSVSSSREDCTDDMTR-----------------------S-EQSPK-DMS----HPCA
PIKDSTRDNTAAFLTQRSKNE--------------------------------VGMYHDPHVEDGASSKE
NRMIFTESMPRRVGSFYR---------------------------------------VPSPRPDNSSSFH
DGVGQGRGPVVPVVPGDPVAMANHSKRQTAFD-W-----TTAEAMVM--NPPEPAKEKEKQGFFRAIKKK
KKKSQITDMEDGRNPSIKKSLFPLFSSKNSLKHNSAVKVLPVVASPM-----------------------
------------------------VQHQPAAPYPASP---------------------------------
-----------VPGN-GQDHLS-LQRSSKSSSHHS------SRRKNRERSRDRDRDREQSRDRDRERERE
RE---RER--ERERERERGRE------RERVNDW-PDKQVDSHS--------------------------
--------Q----------------SQPLKSLRRLLHL-SPSSSNQGQA---PPPPPPQD----LRFQAP
MPNPPQPSSKA-GYPEGRGHADSRGHTGV----SSS----------------------AQAKSRKA-SYP
LP------------------------------------------------------G-------------
----------------------------------------------------------------------
----------------------------------------------------------------------
-----------------------------------------------QIESSWHVSALQR--AEGAQFTP
EQLGIKPGQNGPTFTRASRTRMPNLNDLKETAL-------------------------------------
-----------
>cdkl5_DANRE PROTID=ENSDARP00000111280 TRANSID=ENSDART00000127502 GENEID=ENSDARG00000015240 TAXID=7955
MKIPDIGNVMNKFEVLGIVGEGAYGV-----------------------------VLKCRH---------
-----------------------------------------------K----------ETKELVAIKKFK
DSEENEEVKETTLRELKMLRTLKQDNIVELKEAFRRRGKLYLVFEYVEKNMLELLEELPNGALPDKVRSY
IFQLIKAIHWCHKNEIVHRDIKPE-------NLLISANDILKLCDFG--FARNLSEGSDANYTEYVATRW
YRSPELLLGAPYGKAVDMWSVGCILGELSDGQPLFPGESEIDQLFTIQKVLGPLPPEQMKLFYSNPRFAG
LRFPSVSHPQTLDRRYLGIINGLMLDLMKNLLCLNPTERFLTEQCLNHPVFQGLR--------GPEQPAV
PSPTPPRSSKRKP-YH-GDNTIPS-----R----SHGSKSS----SHRRANSKDCSSLP----RHEDL-H
RSTDSFLNGTNMPTSSTLSPTLHPKS-YQAQTLSRSASSNKDLANNNLPHLLSPKDAKGKTEFDFNLG--
PKV-----GVASVGMDTSTGKY--LK-S------SKQ---------------------------------
-----------GRHSSFLE---GKTSTLQSG-DK-HSRHNY-ME-SSHGSMPSTSSSKSSSSFLSLSKSH
GALNDAKSVSNLAETRLHLDDP------MAGSGSGSRYFPSSCLDLNA------APGSPRGERHAGTE-R
QGH------SPSG-RG---S---N-RLEGGTLD--SRRSSGRK-KT--PDEPKPT-DTLDPSR--A--AG
GHAHNLPSPHESYPYGLGYTSPFSSQQRPHRHSMYVRRERHRPHGQENNLV----VGQGVPTRASSLQLL
SPQLQHR-TLPRHNTSSSREELTPELSR-----------------------N-DQSPK-EKP----HSRP
LIKDSTRDNTATFHTQRPKNE--------------------------------AGMYHDAHMEDGTSSKE
NRIIYSDSMPRRVGSFYR---------------------------------------VPSPRPDN--TFL
ETTGQSR--VQAVAAENPT-MTNHSKRQTNFDPW-----NNSEAMVM--NPPEVPKQKEKQGFFRAIKKK
KKKSQPTDGNAGRNPSIKKSLFPLFNSKNSLKHNSSVKVLPVVPQPM-----------------------
----------------------------------------------------------------------
-----------VPSETQQDQL-VLQRPVKSSSHHS------SRH----RNRDRERERDMERDRE--RERD
RN---RDR--DRERDRD--------------NTWPPEKQPEVQP--------------------------
--------Q----------------NQPLKSLRKLLHLSSPATSNQP--------PPP-DRSAELRFQ-P
LPNP--P-SKA-NLNE------VRGHPAG----SVT----------------------PNTKSRKPHNYP
LP------------------------------------------------------G-------------
----------------------------------------------------------------------
----------------------------------------------------------------------
-----------------------------------------------QIESSWHVSALNR--AEGAPY-P
DQLANKGGQNGIGFTRAARTRMPNLNDLKETAL-------------------------------------
-----------
>CDKL5_SARHA PROTID=ENSSHAP00000007450 TRANSID=ENSSHAT00000007512 GENEID=ENSSHAG00000006474 TAXID=9305
---------MNKFEILGVVGEGAYGV-----------------------------VLKCRH---------
-----------------------------------------------K----------ETHEIVAIKKFK
DSEENEEVKETTLRELKMLRTLKQENIVELKEAFRRRGKLYLVFEYVEKNMLELLEEMPNGVPPEKVKSY
IYQLIKAIHWCHKNDIVHRDIKPE-------NLLISHSDILKLCDFG--FARNLSEGNNANYTEYVATRW
YRSPELLLGAPYGKSVDMWSVGCILGELSDGQPLFPGESEIDQLFTIQKVLGPLPSEQMKLFYSNPRFHG
LRFPAVNHPQSLERRYLGILSGVLLDLMKNLLKLDPADRYLTEQCLNHPSFQTQRLL--DR-CG------
--TSPSRSAKRKP-YHVESNTLSN-----R----NQASKNTALQ-AHHRSNSKDIQNLSVGLPRNEDV-L
PASESFLNG-NLS-GASHSP-MHTKP-YQ-TS-NPPGSANKDLTNNNIPHLLSPKESKAKTEFDFSID--
QKTSE-GPGT----------KY--LK-SNSR---SQQ---------------------------------
-----------NRH-SFMESSQSKTGTLQPG-EK-HGRHSY-ID-TI----P--QSS-KSPSYRAKAKSH
GVLTDSKSVSNLSEARVQISDPS-SS----------RYFPSSCLDLNSPT-------SPIPPRH--SDSR
TLL------SPSG-R----T---N-RSE-GTLD--SRRTTARHSKT--MEELKLP-DH---------MDG
SHSHSLSAPHESFSYGLGYTSPFSSQQRPHRHSMYVTRDKVRAKGSDGGLN----IGQGMAVRANSLQLL
SPQ------------------------------------------------PGEQIPT-ELS----VSRS
SAKETSREGTSSFHS-RQKSE--------------------------------GGAYHDPHSDDGGATKE
NRHLYNDPVPRRVGSFYR---------------------------------------VPSPRPDN--SFH
ENNVPSRV---ASLPSESSSGTNHSKRQTTFDPW-----KSPEN--I-SH-AEQLKEKEKQSFFRSMKKK
KKKSQT----------------------------------------------------------------
----------------------------------------------------------------------
-----------VPNTDSQDLL-ALQKAIHSTNHQS------SRP----------------------K---
--------------------------------EWRPEKISDLQV--------------------------
--------H----------------SQPLKSLRKLLHLSSA--SNHP--------TSS-D----PRFQ-V
-PSQ--Q-AKS-SFSE------VRIHPMSQASSSSS-NSNI--RAE------------ATPKAR--PTLQ
LP------------------------------------------------------G-------------
----------------------------------------------------------------------
----------------------------------------------------------------------
----------------------------------------------------------------------
----------------------------------------------------------QEEVVWFSSPAP
PRPPYLHLKKV
>CDKL5_MONDO PROTID=ENSMODP00000021387 TRANSID=ENSMODT00000021762 GENEID=ENSMODG00000017140 TAXID=13616
----------------------------------------------------------------------
----------------------------------------------------------------------
---ENEEVKETTLRELKMLRTLKQENIVELKEAFRRRGKLYLVFEYVEKNMLELLEEMPNGVPPDKVKSY
IYQLIKAIHWCHKNDIVHRDIKPE-------NLLISHSDILKLCDFG--FARNLSEGNNANYTEYVATRW
YRSPELLLGAPYGKSVDMWSVGCILGELSDGQPLFPGESEIDQLFTIQKVLGPLPSEQMKLFYSNPRFHG
LRFPAVNHPQSLERRYLGILSGVLLDLMKNLLKLDPADRYLTEQCLNHPSFQTQRLL--DR-CG------
--TSPSRSAKRKP-YHVESNTLSN-----R----NQASKNAALQ-AHHRSNSKDIQNLSVGLPRNEDV-L
PANESFLNG-NLS-AASHSP-MHTKP-YQ-TS-NPPGSANKDLTNNNIPHLLSPKETKSKTEFDFNID--
QKASE-GPGT----------KY--LK-SNSR---SQQ---------------------------------
-----------NRH-SFMESSQSKTGTLQPG-EK-HGRHSY-ID-TI----P--QSS-KSPSYRAKAKSH
GILTDSKSVSNLSEARVQISDPS-SG----------RYFPSSCLDLNSPT-------SPTPPRH--SDSR
TLL------SPSG-R----T---N-RSE-GTLD--SRRTATRHSKT--MEELKLP-DH---------MDG
SHSHSLSAPHESFSYGLGYTSPFSSQQRPHRHSMYVTRDKVRAKGSDGGLN----IGQGMAVRANSLQLL
SPQ------------------------------------------------PGEQIPT-ELS----VSRS
SAKETSRDGTSSFHS-RQKSE--------------------------------GGAYHDPHSDDGAATKE
NRHLYNDPVPRRVGSFYR---------------------------------------VPSPRPDN--SFH
ENNVPSRV---ASLPAESSSGTNHPKRQTTFDPW-----KSPEN--I-SQ-AEQLKEKEKQGFFRSMKKK
KKKAQT----------------------------------------------------------------
----------------------------------------------------------------------
-----------VPNSDSQDLL-ALQKAIHSTNHQS------SRP----------------------K---
--------------------------------EWRPEKISDLQV--------------------------
--------H----------------SQPLKSLRKLLHLSSA--SNHS--------TSS-D----PRFQ-A
LPSQ--Q-AKS-SFSE------VRIHPMSQASSSSSGGSNV--RAE------------ATPKAR--PTLQ
LP------------------------------------------------------G-------------
----------------------------------------------------------------------
----------------------------------------------------------------------
----------------------------------------------------------------------
----------------------------------------------------------------------
-----------
>CDKL5_BOVIN PROTID=ENSBTAP00000009766 TRANSID=ENSBTAT00000009766 GENEID=ENSBTAG00000007428 TAXID=9913
----------------------------------------------------------------------
----------------------------------------------------------------------
---ENEEVKETTLRELKMLRTLKQENIVELKEAFRRRGKLYLVFEYVEKNMLELLEEMPNGVPPEKVKSY
IYQLIKAIHWCHKNDIVHRDIKPE-------NLLISHNDVLKLCDFG--FARNLSEGNNANYTEYVATRW
YRSPELLLGAPYGKSVDMWSVGCILGELSDGQPLFPGESEIDQLFTIQKVLGPLPSEQMKLFYSNPRFHG
LRFPAVNHPQSLERRYLGILNSVLLDLMKNLLKLDPADRYLTEQCLNHPTFQTQRLL--DR---------
---SPSRSAKRKP-YHV------NNWFPMR----NQASKSAALQ-SHHRSNSKDIQNLGVGLPRADEG-L
PANESFLNG-NLA-GATLSP-MHTKT-YQ-AG-SQPGSTSKDLTNNNIPHLLSPKEAKSKTEFDFNID--
PKPSD-GPGT----------KY--LK-SSSR---SQQ---------------------------------
-----------NRH-SFMESSQSKAGTLQPG-EK-QSRHSY-ID-TI----P--QSS-RSPSYRTKAKSH
GALSDSKSVSNLSEARAQIAESS-TS----------RYFPSSCLDLNSPT-------SPTPTRH--GDTR
TLL------SPSG-R----N---N-RSE-GTLD--SRRTTTRHSKT--MEELKLP-EH---------MDS
SHSHSLSAPHESFSYGLGYTSPFSSQQRPHRHSMYVTRDKVRAKGLDGSLS----IGQGMAARANSLQLL
SPQ-------------------------VRLRALTRCVGSSGEDGSDVEVEPGEQLPP-EMT----VARS
SVKESSREGTSSFHV-RQKSE--------------------------------GGAYHDPHSDDGAAPKE
NRHLYNDPVPRRVGSFYR---------------------------------------VPSPRPDN--SFH
ENNVSTRV---SSLPSESSSGTNHSKRQPAFDPC--NSGKSPEN--I-SH-SEQLKEKEKQGFFRSMKKK
KKKSQT----------------------------------------------------------------
----------------------------------------------------------------------
-----------VPNSDGPDLL-TLQKAIHSASTPS------SRP----------------------K---
--------------------------------EWRPEKISDLQTQFSPEGRERDHWDFAMPRERENRGDK
KKRGRTKAQ----------------SQPLKSLRKLLHLSSA--SNHP--------ASS-D----PRFQ-P
LTTQ--Q-AKN-SFSE------IRIHPLSQA---SGGSSNI--RQE------------PTPKGR--PALQ
LP------------------------------------------------------G-------------
----------------------------------------------------------------------
----------------------------------------------------------------------
-----------------------------------------------QMDPGWHVSSVTRSATEGPSY-S
EQLGAKSGPNGHPYNRTNRSRMPNLNDLKETAL-------------------------------------
-----------
>CDKL5_PIG PROTID=ENSSSCP00000012941 TRANSID=ENSSSCT00000013297 GENEID=ENSSSCG00000012156 TAXID=9823
----------------------------------------------------------------------
-----------------------------------------------Q----------ETHEIVAIKKFK
DSEENEEVKETTLRELKMLRTLKQENIVELKEAFRRRGKLYLVFEYVEKNMLELLEEMPNGVPPEKVKSY
IYQLIKAIHWCHKNDIVHRDIKPE-------NLLISHNDVLKLCDFG--FARNLSEGNNANYTEYVATRW
YRSPELLLGAPYGKSVDMWSVGCILGELSDGQPLFPGESEIDQLFTIQKVLGPLPSEQMKLFYSNPRFHG
LRFPAVNHPQSLERRYLGILNSVLLDLMKNLLKLDPADRYLTEQCLNHPTFQTQRLL--DR---------
---SPSRSAKRKP-YHVESSTLSN-----R----NQASKTAALQ-SHHRSNSKDIQNLGVGLPRADEG-L
PANESFLNG-NLA-GATLSP-MHTKT-YQ-AS-SQPGSASKDLTNNNIPHLLSPKEAKSKTEFDFNID--
PKPSE-GPGT----------KY--LK-SSSR---SQQ---------------------------------
-----------NRH-SFMESSQSKAGTLQPS-EK-QSRHSY-ID-TI----P--QSS-RSPSYRTKAKSH
GALSDSKSVSNLSEARAQMAESN-TS----------RYFPSSCLDLNSPT-------SPTPTRH--SDTR
TLL------SPSG-R----N---N-RSE-GTLD--SRRTTTRHSKT--MEELKLP-EH---------MDS
SHSHSLSAPHESFSYGLGYTSPFSSQQRPHRHSMYVTRDKVRAKGLDGSLS----VGQGMAARANSLQLL
SPQ------------------------------------------------PGEQLPP-EMT----VARS
SGKESSREGTSSFHA-RQKSE--------------------------------GGAYHDPHSDDGNAPKE
NRHLYNDPVPRRVGSFYR---------------------------------------VPSPRPDN--SFH
ENNVSTRV---SSLPSESSSGTNHSKRQPAFDPW-----KSPEN--I-SH-SEQLKEKEKQGFFRSMKKK
KKKSQT----------------------------------------------------------------
----------------------------------------------------------------------
-----------VPNSDGPDLL-TLQKAIHSASTPS------SRP----------------------K---
--------------------------------EWRPEKISDLQT--------------------------
--------Q----------------SQPLKSLRKLLHLSSA--SNHP--------ASS-D----PRFQ-P
LTTQ--Q-AKN-SFSE------IRIHPLSQA---SGGSSNI--RQE------------PTPKGR--PALQ
LP------------------------------------------------------G-------------
----------------------------------------------------------------------
----------------------------------------------------------------------
----------------------------------------------------------------------
----------------------------------------------------------------------
-----------
>CDKL5_MYOLU PROTID=ENSMLUP00000006227 TRANSID=ENSMLUT00000006819 GENEID=ENSMLUG00000006808 TAXID=59463
----------------------------------------------------------------------
----------------------------------------------------------------------
---ENEEVKETTLRELKMLRTLKQENIVELKEAFRRRGKLYLVFEYVEKNMLELLEEMPNGVPPEKVKSY
IYQLIKAIHWCHKNDIVHRDIKPE-------NLLISHNDVLKLCDFG--FARNLSEGNNANYTEYVATRW
YRSPELLLGAPYGKSVDMWSVGCILGELSDGQPLFPGESEIDQLFTIQKVLGPLPSEQMKLFYSNPRFHG
LRFPAVNHPQSLERRYLGILNSVLLDLMKNLLKLDPAERYLTEQCLNHPAFQTQRLL--DR---------
---SPSRSAKRKP-YHVESSTLSN-----R----NQASKSTALQ-SHHRSNSKDIQNLSVGLPRAEEG-L
PASESFLNG-NLA-GATLSP-MHTKT-YQ-AS-SQPGSTSKDLTNNNLTHLLSPKETKSKSEFDFNID--
PKPSE-GPGT----------KY--LK-SNTR---SQQ---------------------------------
-----------NRH-SFMESSQSKAGTLQPS-EK-QSRHSY-ID-TI----P--QSS-RSPSYRTKTKSH
GALSDSKSVSNLSESRAQIAESN-TN----------RYFPSSCLDLNSPT-------SPTPTRH--SDTR
TLL------SPSG-R----N---N-RSE-GTLD--SRRTTARHSKT--MDELKLP-DH---------VDS
SHSHSLSAPHESFSYGLGYTSPFSSQQRPHRHSMYVTRDKVRAKGLDGSLS----IGQGMAARANSLQLL
SPQ------------------------------------------------PGEQLPP-EMT----VARS
SVKEPSREGNSAFHT-RQKSE--------------------------------GGAYHDPHSDDGTAPKE
NRHLYNDPVPRRVGSFYR---------------------------------------VPSPRPDN--SFH
ENNVSSRV---SSLPSESSSGTNHSKRQPAFETW-----KGPEN--I-SH-SEQLKEKEKQGFFRSMKKK
KKKSQT----------------------------------------------------------------
----------------------------------------------------------------------
-----------LSNSEGPDLL-TLQKAIHS-NTTT------GRP----------------------K---
--------------------------------EWRPEKISDLQP--------------------------
--------Q----------------SQPLKSLRKLLHLSSA--SNHP--------ATG-D----PRFQ-P
LTPQ--Q-VKN-AFSE------IRIHSLAQA---SGASSNI--RQE------------PTPKGR--PALQ
LP----------------------------VSPLHFSCSAIPVKLGKARMCSGTARK-------------
----------------------------------------------------------------------
----------------------------------------------------------------------
----------------------------------------------------------------------
----------------------------------------------------------------------
-----------
>CDKL5_OTOGA PROTID=ENSOGAP00000002170 TRANSID=ENSOGAT00000002432 GENEID=ENSOGAG00000002429 TAXID=30611
----------------------------------------------------------------------
----------------------------------------------------------------------
---ENEEVKETTLRELKMLRTLKQENIVELKEAFRRRGKLYLVFEYVEKNMLELLEEMPNGVPPEKVKSY
IYQLIKAIHWCHKNDIVHRDIKPE-------NLLISHNDVLKLCDFG--FARNLSEGNNANYTEYVATRW
YRSPELLLGAPYGKSVDMWSVGCILGELSDGQPLFPGESEIDQLFTIQKVLGPLPSEQMKLFYSNPRFHG
LRFPAVNHPQSLERRYLGILNSILLDLMKNLLKLDPADRYLTEQCLNHPTFQTQRLL--DR---------
---SPSRSTKRKP-YHVESSTLSN-----R----NQASKGAALQ-SHHRSNSKDIQNLSVGLPRADEG-L
PANESFLNG-NLA-GATLSP-MHTKT-YQ-AG-TQPGPTSKDLTNNNLPHLLSPKEAKSKTEFDFNID--
TKPSE-GPGT----------KY--LK-SSSR---SQQ---------------------------------
-----------NRH-SFMESSQSKAGTLQPT-EK-QSRHSY-ID-TI----P--QSS-RSPSYRTKAKSH
GALSDSKSVSNLSEARAQITESN-TS----------RYFPSSCLDLNSPT-------SPTPTRH--SDTR
TLL------SPSG-R----N---N-RNE-GTLD--SRRTTTRHSKT--MEELKLP-EH---------IDS
SHSHSLSTPHESFSYGLGYTSPFSSQQRPHRHSMYVTRDKVRAKGLDGSLS----IGQGMAARANSLQLL
SPQ------------------------------------------------PGEQLPP-EMT----VARS
SVKESSRDGTSSFHT-RQKTE--------------------------------GGVYHDPHSDDGTAPKE
NRHLYNDPVPRRVGSFYR---------------------------------------VPSPRPDN--SFH
ENNVSSRV---SSLPSESSSGTNHSKRQPAFDPW-----KSPEN--I-SH-SEQLKEKEKQGFFRSMKKK
KKKSQT----------------------------------------------------------------
----------------------------------------------------------------------
-----------VPNSDGPDLL-TLQKAIHTASTPS------SRP----------------------K---
--------------------------------EWRPEKISDLQT--------------------------
--------Q----------------SQPLKSLRKLLHLPTA--SNHP--------TSS-D----PRFQ-P
LTAQ--Q-AKN-TFSE------IRIHPLSQA---SGGSTNI--RPE------------PAPKGR--PPLP
LP----------------------------VSPPY-----------------------------------
----------------------------------------------------------------------
----------------------------------------------------------------------
----------------------------------------------------------------------
----------------------------------------------------------------------
-----------
>CDKL5_HUMAN PROTID=ENSP00000369332 TRANSID=ENST00000379996 GENEID=ENSG00000008086 TAXID=9606
MKIPNIGNVMNKFEILGVVGEGAYGV-----------------------------VLKCRH---------
-----------------------------------------------K----------ETHEIVAIKKFK
DSEENEEVKETTLRELKMLRTLKQENIVELKEAFRRRGKLYLVFEYVEKNMLELLEEMPNGVPPEKVKSY
IYQLIKAIHWCHKNDIVHRDIKPE-------NLLISHNDVLKLCDFG--FARNLSEGNNANYTEYVATRW
YRSPELLLGAPYGKSVDMWSVGCILGELSDGQPLFPGESEIDQLFTIQKVLGPLPSEQMKLFYSNPRFHG
LRFPAVNHPQSLERRYLGILNSVLLDLMKNLLKLDPADRYLTEQCLNHPTFQTQRLL--DR---------
---SPSRSAKRKP-YHVESSTLSN-----R----NQAGKSTALQ-SHHRSNSKDIQNLSVGLPRADEG-L
PANESFLNG-NLA-GASLSP-LHTKT-YQ-AS-SQPGSTSKDLTNNNIPHLLSPKEAKSKTEFDFNID--
PKPSE-GPGT----------KY--LK-SNSR---SQQ---------------------------------
-----------NRH-SFMESSQSKAGTLQPN-EK-QSRHSY-ID-TI----P--QSS-RSPSYRTKAKSH
GALSDSKSVSNLSEARAQIAEPS-TS----------RYFPSSCLDLNSPT-------SPTPTRH--SDTR
TLL------SPSG-R----N---N-RNE-GTLD--SRRTTTRHSKT--MEELKLP-EH---------MDS
SHSHSLSAPHESFSYGLGYTSPFSSQQRPHRHSMYVTRDKVRAKGLDGSLS----IGQGMAARANSLQLL
SPQ------------------------------------------------PGEQLPP-EMT----VARS
SVKETSREGTSSFHT-RQKSE--------------------------------GGVYHDPHSDDGTAPKE
NRHLYNDPVPRRVGSFYR---------------------------------------VPSPRPDN--SFH
ENNVSTRV---SSLPSESSSGTNHSKRQPAFDPW-----KSPEN--I-SH-SEQLKEKEKQGFFRSMKKK
KKKSQT----------------------------------------------------------------
----------------------------------------------------------------------
-----------VPNSDSPDLL-TLQKSIHSASTPS------SRP----------------------K---
--------------------------------EWRPEKISDLQT--------------------------
--------Q----------------SQPLKSLRKLLHLSSA--SNHP--------ASS-D----PRFQ-P
LTAQ--Q-TKN-SFSE------IRIHPLSQA---SGGSSNI--RQE------------PAPKGR--PALQ
LPDGGCDGRRQRHHSGPQDRRFMLRTTEQQ--------------------------G-------------
-------------------------------------------EYFCCGDPKKPHT--------------
---------------------------------PCVPNRALHRPISSPAPYPVLQVRGTSMCPTLQVRGT
DAFSCPTQQSGFSFFVRHVMREALIHRAQVNQAALLTYHENAALTGK-----------------------
----------------------------------------------------------------------
-----------
>CDKL5_Ggor PROTID=ENSGGOP00000010529 TRANSID=ENSGGOT00000010838 GENEID=ENSGGOG00000010796 TAXID=9593
MKIPNIGNVMNKFEILGVVGEGAYGV-----------------------------VLKCRH---------
-----------------------------------------------K----------ETHEIVAIKKFK
DSEENEEVKETTLRELKMLRTLKQENIVELKEAFRRRGKLYLVFEYVEKNMLELLEEMPNGVPPEKVKSY
IYQLIKAIHWCHKNDIVHRDIKPE-------NLLISHNDVLKLCDFG--FARNLSEGNNANYTEYVATRW
YRSPELLLGAPYGKSVDMWSVGCILGELSDGQPLFPGESEIDQLFTIQKVLGPLPSEQMKLFYSNPRFHG
LRFPAVNHPQSLERRYLGILNSVLLDLMKNLLKLDPADRYLTEQCLNHPTFQTQRLL--DR---------
---SPSRSAKRKP-YHVESSTLSN-----R----NQAGKSTALQ-SHHRSNSKDIQNLSVGLPRADEG-L
PANESFLNG-NLA-GASLSP-LHTKT-YQ-AS-SQPGSTSKDLTNNNIPHLLSPKEAKSKTEFDFNID--
PKPSE-GPGT----------KY--LK-SNSR---SQQ---------------------------------
-----------NRH-SFMESSQSKAGTLQPN-EK-QSRHSY-ID-TI----P--QSS-RSPSYRTKAKSH
GALSDSKSVSNLSEARAQIAEPS-TS----------RYFPSSCLDLNSPT-------SPTPARH--SDTR
TLL------SPSG-R----N---N-RNE-GTLD--SRRTTTRHSKT--MEELKLP-EH---------MDS
SHSHSLSAPHESFSYGLGYTSPFSSQQRPHRHSMYVTRDKVRAKGLDGSLS----IGQGMAARANSLQLL
SPQ------------------------------------------------PGEQLPP-EMT----VARS
SVKETSREGTSSFHT-RQKSE--------------------------------GGVYHDPHSDDGTAPKE
NRHLYNDPVPRRVGSFYR---------------------------------------VPSPRPDN--SFH
ENNVSTRV---SSLPSESSSGTNHSKRQPAFDPW-----KSPEN--I-SH-SEQLKEKEKQGFFRSMKKK
KKKSQT----------------------------------------------------------------
----------------------------------------------------------------------
-----------VPNSDSPDLL-TLQKSIHSASTPS------SRP----------------------K---
--------------------------------EWRPEKISDLQT--------------------------
--------Q----------------SQPLKSLRKLLHLSSA--SNHP--------ASS-D----PRFQ-P
LTAQ--Q-TKN-SFSE------IRIHPLSQA---SGGSSNI--RQE------------PTPKGR--PALQ
LPEGGCDGRRQRHHSGPQDRRFMLRTTE-Q--------------------------G-------------
-------------------------------------------EYFRCGDPKKPHT--------------
---------------------------------PCVPNRALHRPTSSPAPYPVLQVRGTSMCPTLQVRGT
DAFSCPTQQSGFSFFVRHVMREALIHRAQVNQAALLTYHENVALTGK-----------------------
----------------------------------------------------------------------
-----------
>CDKL5_NOMLE PROTID=ENSNLEP00000011782 TRANSID=ENSNLET00000012362 GENEID=ENSNLEG00000009674 TAXID=61853
---------MNKFEILGVVGEGAYGV-----------------------------VLKCRH---------
-----------------------------------------------K----------ETHEIVAIKKFK
DSEENEEVKETTLRELKMLRTLKQENIVELKEAFRRRGKLYLVFEYVEKNMLELLEEMPNGVPPEKVKSY
IYQLIKAIHWCHKNDIVHRDIKPE-------NLLISHNDVLKLCDFG--FARNLSEGNNANYTEYVATRW
YRSPELLLGAPYGKSVDMWSVGCILGELSDGQPLFPGESEIDQLFTIQKVLGPLPSEQMKLFYSNPRFHG
LRFPAVNHPQSLERRYLGILNSVLLDLMKNLLKLDPADRYLTEQCLNHPTFQTQRLL--DR---------
---SPSRSAKRKP-YHVESSTLSN-----R----NQAGKSTALQ-SHHRSNSKDIQNLSVGLPRADEG-I
PANESFLNG-NLA-GASLSP-LHTKT-YQ-AS-SQPGSTSKDLTNNNIPHLLSPKEAKSKTEFDFNID--
PKPSE-GPGT----------KY--LK-SNSR---SQQ---------------------------------
-----------NRH-SFMESSQSKAGTLQPN-EK-QSRHSY-ID-TI----P--QSS-RSPSYRTKAKSH
GALSDSKSVSNLSEARAQIAEPS-TS----------RYFPSSCLDLNSPT-------SPTPTRH--GDTR
TLL------SPSG-R----N---N-RNE-GTLD--SRRTTTRHSKT--MEELKLP-EH---------MDS
SHSHSLSAPHESFSYGLGYTSPFSSQQRPHRHSMYVTRDKVRAKGLDGSLS----IGQGMAARANSLQLL
SPQ------------------------------------------------PGEQLPP-EMT----VARS
SVKETSREGTSSFHT-RQKSE--------------------------------GGVYHDPHSDDGTAPKE
NRHLYNDPVPRRVGSFYR---------------------------------------VPSPRPDN--SFH
ENNVSTRV---SSLPSESSSGTNHSKRQPAFDPW-----KSPEN--I-SH-SEQLKEKEKQGFFRSMKKK
KKKSQT----------------------------------------------------------------
----------------------------------------------------------------------
-----------VPNSDSPDLL-TLQKSIHSTSTPS------SRP----------------------K---
--------------------------------EWRPEKISDLQT--------------------------
--------Q----------------SQPLKSLRKLLHLSSA--SNHP--------ASS-D----PRFQ-P
LTAQ--Q-TKN-SFSE------IRIHPLSQA---SGGSSNI--RQE------------PAPKGR--PALQ
LPECGCDGRRWRHHSGPQDRRFMLRTTEQQ--------------------------G-------------
-------------------------------------------EYFRCGDSKKPHTSVSEIAPLHSSLGD
RARLPRLHLKKKKTKGILIRHTQNMTFPSFPPR-------------------------------------
-----------FSFFV------------------------------------------------------
----------------------------------------------------------------------
-----------
>LOC693974_MACMU PROTID=ENSMMUP00000006707 TRANSID=ENSMMUT00000007138 GENEID=ENSMMUG00000005063 TAXID=9544
MKIPNIGNVMNKFEILGVVGEGAYGV-----------------------------VLKCRH---------
-----------------------------------------------K-AR-------ETHEIVAIKKFK
DSEENEEVKETTLRELKMLRTLKQENIVELKEAFRRRGKLYLVFEYVEKNMLELLEEMPNGVPPEKVKSY
IYQLIKAIHWCHKNDIVHRDIKPE-------NLLISHNDVLKLCDFG--FARNLSEGNNANYTEYVATRW
YRSPELLLGAPYGKSVDMWSVGCILGELSDGQPLFPGESEIDQLFTIQKVLGPLPSEQMKLFYSNPRFHG
LRFPAVNHPQSLERRYLGILNSVLLDLMKNLLKLDPADRYLTEQCLNHPTFQTQRLL--DR---------
---SPSRSAKRKP-YHVESSTLSN-----R----NQAGKSTALQ-SHHRSNSKDIQNLSVGLPRADEG-L
PANESFLNG-NLA-GASLSP-LHTKT-YQ-AS-SQPGSTSKDLTNNNIPHLLSPKEAKSKTEFDFNID--
PKPSE-GPGT----------KY--LK-SNSR---SQQ---------------------------------
-----------NRH-SFMESSQSKAGTLQPN-EK-QSRHSY-ID-TI----P--QSS-RSPSYRTKAKSH
GALSDSKSVSNLSEARAQIAEPS-TS----------RYFPSSCLDLNSPT-------SPTPTRH--SDTR
TLL------SPSG-R----N---N-RNE-GTLD--SRRTTTRHSKT--MEELKLP-EH---------MDS
SHSHSLSAPHESFSYGLGYTSPFSSQQRPHRHSMYVTRDKVRAKGLDGSLS----IGQGMAARANSLQLL
SPQ------------------------------------------------PGEQLPP-EMT----VARS
SVKETTREGSSSFHT-RQKSE--------------------------------GGVYHDPHSDDGTAPKE
NRHLYNDPVPRRVGSFYR---------------------------------------VPSPRPDN--SFH
ENNVSTRV---SSLPSESSSGTNHSKRQPAFDPW-----KSPEN--I-SH-SEQLKEKEKQGFFRSMKKK
KKKSQT----------------------------------------------------------------
----------------------------------------------------------------------
-----------VPNSDSPDLL-TLQKSIHSASTPS------SRP----------------------K---
--------------------------------EWRPEKISDLQT--------------------------
--------Q----------------SQPLKSLRKLLHLSSA--SNHP--------ASS-D----PRFQ-P
LTAQ--Q-TKN-SFSE------IRIHPLSQA---SGGSSNI--RQE------------PAPKGR--PALQ
LPECGCDGRTERHHSGPQDRRFMLRTTKQQ--------------------------G-------------
----------------------------------------------------------------------
----------------------------------------------------------------------
----------------------------------------------------------------------
----------------------------------------------------------------------
-----------
>CDKL5_CALJA PROTID=ENSCJAP00000010773 TRANSID=ENSCJAT00000011379 GENEID=ENSCJAG00000005834 TAXID=9483
MKIPNIGNVMNKFEILGVVGEGAYGV-----------------------------VLKCRH---------
-----------------------------------------------K-AS-------ETHEIVAIKKFK
DSEENEEVKETTLRELKMLRTLKQENIVELKEAFRRRGKLYLVFEYVEKNMLELLEEMPNGVPPEKVKSY
IYQLIKAIHWCHKNDIVHRDIKPE-------NLLISHNDVLKLCDFG--FARNLSEGNNANYTEYVATRW
YRSPELLLGAPYGKSVDMWSVGCILGELSDGQPLFPGESEIDQLFTIQKVLGPLPSEQMKLFYSNPRFHG
LRFPAVNHPQSLERRYLGILNSVLLDLMKNLLKLDPADRYLTEQCLNHPTFQTQRLL--DR---------
---SPSRSAKRKP-YHVESSTLSN-----R----NQAGKSTALQ-SHHRSNSKDIQNLSVGLPRADEG-L
PANESFLNG-NLA-GASLSP-MHTKT-YQ-AS-SQPGSTSKDLTNNNIPHLLSPKEAKSKTEFDFNID--
PKPSE-GPGT----------KY--LK-SNSR---SQQ---------------------------------
-----------NRH-SFMESSQSKAGTLQPN-EK-QSRHSY-ID-TI----P--QSS-RSPSYRTKAKSH
GALSDSKSVSNLSEARAQITEPS-SS----------RYFPSSCLDLNSPT-------SPTPTRH--SDTR
TLL------SPSG-R----N---N-RNE-GTLD--SRRTTTRHSKT--MEELKLP-EH---------MDS
SHSHSLSAPHESFSYGLGYTSPFSSQQRPHRHSMYVTRDKVRAKGLDGSLS----IGQGMAARANSLQLL
SPQ------------------------------------------------PGEQLPP-EMT----VARS
SVKETSREGTSSFHT-RQKSE--------------------------------GGVYHDPHSDDGTAPKE
NRHLYNDPMPRRVGSFYRGKPTPSIHQALLASELASLSSLLTGTHQYSDWSEGFLPK-------------
---------------------------------------KSPEN--I-SH-SEQLKEKEKQGFFRSMKKK
KKKSQT----------------------------------------------------------------
----------------------------------------------------------------------
-----------VPNSDSPDLL-TLQKSIHSTSTPS------SRP----------------------K---
--------------------------------EWRPEKISDLQT--------------------------
--------Q----------------SQPLKSLRKLLHLSST--SNHP--------ASS-D----PRFQ-P
LTAQ--Q-TKN-SFSE------IRIHPLSQA---SGGSSNI--RQE------------PAPKGR--PALQ
LP--------------------------------------------------------------------
----------------------------------------------------------------------
----------------------------------------------------------------------
----------------------------------------------------------------------
----------------------------------------------------------------------
-----------
>CDKL5_CAVPO PROTID=ENSCPOP00000006709 TRANSID=ENSCPOT00000007510 GENEID=ENSCPOG00000007438 TAXID=10141
MKIPNIGNVMNKFEILGVVGEGAYGV-----------------------------VLKCRH---------
-----------------------------------------------K----------ETHEIVAIKKFK
DSEENEEVKETTLRELKMLRTLKQENIVELKEAFRRRGKLYLVFEYVEKNMLELLEEMPNGVPPEKVKSY
IYQLIKAIHWCHKNDIVHRDIKPE-------NLLISHNDVLKLCDFG--FARNLSEGNNANYTEYVATRW
YRSPELLLGAPYGKSVDMWSVGCILGELSDGQPLFPGESEIDQLFTIQKVLGPLPAEQMKLFYSNPRFHG
LRFPAVNHPQSLERRYLGILNSVLLDLMKNLLKLDPADRYLTEQCLNHPTFQTQRLL--DR---------
---SPSRSAKRKP-YHVESSTLSN-----R----SQASKGAALQ-SHHRSNSKDIQNLSVGLPRADEG-L
PANESFLNG-NLA-GATLSP-MHTKT-YQ-AS-TQPGSASKDLTNNNMPHLLSPKEAKSKTEFDFNID--
PKPSE-GPGT----------KY--LK-SSTR---SQQ---------------------------------
-----------NRH-SFMESSQSKAGTLQPS-EK-QSRHSY-ID-TI----P--QSS-RSPSYRTKAKSH
GALSDSKSVSNLSEARAQITETN-TS----------RYFPSSCLDLNSPT-------SPTPTRH--SDSR
TLL------SPSG-R----N---N-RNE-GTLD--SRRTTARHSKT--MEELKLP-EH---------MDN
SHSHSLSAPHESFSYGLGYTSPFSSQQRPHRHSMYVTRDKVRAKGLDGSLS----IGQGMAARANSLQLL
SPQ------------------------------------------------PGEQLPP-EMT----VARP
SVKESSREGTSSFHT-RQKSE--------------------------------GGVYHDPHSDDGTGPKE
NRHLYNDPIPRRVGSFYR---------------------------------------VPSPRPDN--SFH
ENNVSTRV---SSLPSESSSGTNHSKRQPAFDPW-----KSPEN--I-SH-SDQLKEKEKQGFFRSMKKK
KKKSQT----------------------------------------------------------------
----------------------------------------------------------------------
-----------YPNSDGPDLL-TLQK-LHSASASS------SRP----------------------K---
--------------------------------EWRPEKLSDLQT--------------------------
--------Q----------------SQPLKSLRKLLHLSSA--SNHP--------APS-D----PRFQ-P
LTAQ--P-TKN-SFSE------IRIHPLSQA---SGGSSNI--RQE------------PTPKGR--PALQ
LP------------------------------------------------------G-------------
----------------------------------------------------------------------
----------------------------------------------------------------------
----------------------------------------------------------------------
----------------------------------------------------------------------
-----------
>CDKL5_CANFA PROTID=ENSCAFP00000018871 TRANSID=ENSCAFT00000020338 GENEID=ENSCAFG00000012819 TAXID=9615
MKIPNIGNVMNKFEILGVVGEGAYGV-----------------------------VLKCRH---------
-----------------------------------------------K----------ETHEIVAIKKFK
DSEENEEVKETTLRELKMLRTLKQENIVELKEAFRRRGKLYLVFEYVEKNMLELLEEMPNGVPPEKVKSY
IYQLIKAIHWCHKNDIVHRDIKPE-------NLLISHNDVLKLCDFG--FARNLSEGNNANYTEYVATRW
YRSPELLLGAPYGKSVDMWSVGCILGELSDGQPLFPGESEIDQLFTIQKVLGPLPSEQMKLFYSNPRFHG
LRFPAVNHPQTLERRYLGILNSVLLDLMKNLLKLDPADRYLTEQCLNHPTFQTQRLL--DR---------
---SPSRSAKRKP-YHVESSTLSN-----R----NQASKSTALQ-SHHRSNSKDIQNLSVGLPRADEG-L
PANESFLNG-NLA-GATLSP-MHTKT-YQ-AS-SQPGSTSKDLTNNNIPHLLSPKEAKSKTEFDFNID--
PKPSE-GPGT----------KY--LK-SSSR---SQQ---------------------------------
-----------NRH-SFMESSQSKAGTLQPT-EK-QSRHSY-ID-TI----P--QSS-RSPSYRTKAKSH
GALSDSKSVSNLSEARAQIAESN-TS----------RYFPSSCLDLNSPT-------SPTPTRH--SDTR
TLL------SPSG-R----N---N-RSE-GTLD--SRRTTTRHSKT--MEELKLP-EH---------MDS
SHSHSLSAPHESFSYGLGYTSPFSSQQRPHRHSMYVTRDKVRAKGLDGSLS----VGQGMAARANSLQLL
SPQ------------------------------------------------PGEQLPP-EMT----VARS
SVKESSREGTSSFHA-RQKSE--------------------------------GGAYHDPHSDDGAAPKE
NRHLYNDPVPRRVGSFYR---------------------------------------VPSPRPDN--SFH
ENNVSTRV---SSLPSESSSGTNHSKRQPAFDPW-----KSPEN--I-SH-SEQLKEKEKQGFFRSMKKK
KKKSQT----------------------------------------------------------------
----------------------------------------------------------------------
-----------VPNSDGPDLL-TLQKAIHSASTPS------SRP----------------------K---
--------------------------------EWRPEKISDLQT--------------------------
--------Q----------------SQPLKSLRKLLHLSSA--SNHP--------ASS-D----PRFQ-P
LTTQ--Q-AKN-SFSE------IRIHPLSQA---SGGSSNI--RQE------------PTPKGR--PALQ
L-------------------------------------------------------P-------------
--------------------AVFPACVRVPVIEDLTSGYCRFL---------------------------
----------------------------------------------------------------------
----------------------------------------------------------------------
----------------------------------------------------------------------
-----------
>CDKL5_AILME PROTID=ENSAMEP00000017786 TRANSID=ENSAMET00000018510 GENEID=ENSAMEG00000016835 TAXID=9646
MKIPNIGNVMNKFEILGVVGEGAYGV-----------------------------VLKCRH---------
-----------------------------------------------K----------ETHEIVAIKKFK
DSEENEEVKETTLRELKMLRTLKQENIVELKEAFRRRGKLYLVFEYVEKNMLELLEEMPNGVPPEKVKSY
IYQLIKAIHWCHKNDIVHRDIKPE-------NLLISHNDVLKLCDFG--FARNLSEGNNANYTEYVATRW
YRSPELLLGAPYGKSVDMWSVGCILGELSDGQPLFPGESEIDQLFTIQKVLGPLPSEQMKLFYSNPRFHG
LRFPAVNHPQTLERRYLGILNSVLLDLMKNLLKLDPADRYLTEQCLNHPTFQTQRLL--DR---------
---SPSRSAKRKP-YHVESSTLSN-----R----NQASKSAALQ-SHHRSNSKDIQNLGVGLPRADEG-L
PANESFLNG-NLA-GATLSP-MHTKT-YQ-AS-SQPGPTSKDLTNNNIPHLLSPKEAKSKTEFDFNID--
PKPSE-GPGT----------KY--LK-SSTR---SQQ---------------------------------
-----------NRH-SFMESSQSKAGTLQPT-EK-QSRHSY-ID-TI----P--QSS-RSPSYRTKAKSH
GALSDSKSVSNLSEARAQITESN-TS----------RYFPSSCLDLNSPT-------SPTPTRH--SDTR
TLL------SPSG-R----N---N-RSE-GTLD--SRRTTTRHSKT--MEELKLP-EH---------MDS
SHSHSLSAPHESFSYGLGYTSPFSSQQRPHRHSMYVTRDKVRAKGLDGSLS----VGQGMAARANSLQLL
SPQ------------------------------------------------PGEQLPP-EMT----VARS
SVKESSREGTSSFHS-RQKSE--------------------------------GGAYHDPHSDDGTAPKE
NRHLYNDPVPRRVGSFYR---------------------------------------VPSPRPDN--SFH
ENNVSTRV---SSLPSESSSGTNHSKRQPAFDPW-----KSPEN--I-SH-SEQLKEKEKQGFFRSMKKK
KKKSQT----------------------------------------------------------------
----------------------------------------------------------------------
-----------VPNSDGPDLL-TLQKAIHSASTPS------SRP----------------------K---
--------------------------------EWRPEKISDLQT--------------------------
--------Q----------------SQPLKSLRKLLHLSSA--SNHP--------ASS-D----PRFQ-P
LTTQ--Q-AKN-SFSE------IRIHPLSQA---SGGSSNI--RQE------------PTPKGR--PALQ
L-------------------------------------------------------P-------------
----------------------------------------------------------------------
----------------------------------------------------------------------
----------------------------------------------------------------------
----------------------------------------------------------------------
-----------
>CDKL5_HORSE PROTID=ENSECAP00000005338 TRANSID=ENSECAT00000007338 GENEID=ENSECAG00000007008 TAXID=9796
MKIPNIGNVMNKFEILGVVGEGAYGV-----------------------------VLKCRH---------
-----------------------------------------------K----------ETHEIVAIKKFK
DSEENEEVKETTLRELKMLRTLKQENIVELKEAFRRRGKLYLVFEYVEKNMLELLEEMPNGVPPEKVKSY
IYQLIKAIHWCHKNDIVHRDIKPE-------NLLISHNDVLKLCDFG--FARNLSEGNNANYTEYVATRW
YRSPELLLGAPYGKSVDMWSVGCILGELSDGQPLFPGESEIDQLFTIQKVLGPLPSEQMKLFYSNPRFHG
LRFPAVNHPQSLERRYLGILNSVLLDLMKNLLKLDPADRYLTEQCLNHPTFQTQRLL--DR---------
---SPSRSAKRKP-YHVESSTLSN-----R----NQASKSAALQ-SHHRSNSKDIQNLSVGLPRADEG-L
PANESFLNG-NLA-GATLSP-MHTKT-YQ-AS-SQPGSTSKDLTNNNMPHLLSPKEAKSKTEFDFNID--
PKPSE-GPGT----------KY--LK-SSSR---SQQ---------------------------------
-----------NRH-SFMESSQSKAGTLQPS-EK-QSRHSY-ID-TI----P--QSS-RSPSYRTKAKSH
GALSDSKSVSNLSEARAQITESN-TS----------RYFPSSCLDLNSPT-------SPTPTRH--SDTR
TLL------SPSG-R----N---N-RSE-GTLD--SRRTTTRHSKT--MEELKLP-EH---------MDS
SHSHSLSAPHESFSYGLGYTSPFSSQQRPHRHSMYVTRDKVRAKGLDGSLS----VGQGMAARANSLQLL
SPQ------------------------------------------------PGEQLPP-EMT----VARS
SVKESSREGPSSFHT-RQKSE--------------------------------GGSYHDPHSDDGTAPKE
NRHLYNDPVPRRVGSFYR---------------------------------------VPSPRPDN--SFH
ENNVSTRV---SSLPSESGSGTNHSKRQPAFDPW-----KSPEN--I-SH-SEQLKEKEKQGFFRSMKKK
KKKSQT----------------------------------------------------------------
----------------------------------------------------------------------
-----------VPNSDGPDLL-TLQKAIHSASTPS------SRP----------------------K---
--------------------------------EWRPEKISDLQT--------------------------
--------Q----------------SQPLKSLRKLLHLSSA--SNHP--------ASS-D----PRFQ-P
LAAQ--Q-TKN-SFSE------IRIHPLSQA---SGGSSNI--RQE------------PTPKGR--PALQ
LP------------------------------------------------------G-------------
----------------------------------------------------------------------
----------------------------------------------------------------------
----------------------------------------------------------------------
----------------------------------------------------------------------
-----------
>Cdkl5_MOUSE PROTID=ENSMUSP00000084342 TRANSID=ENSMUST00000087104 GENEID=ENSMUSG00000031292 TAXID=10090
MKIPNIGNVMNKFEILGVVGEGAYGV-----------------------------VLKCRH---------
-----------------------------------------------K----------ETHEIVAIKKFK
DSEENEEVKETTLRELKMLRTLKQENIVELKEAFRRRGKLYLVFEYVEKNMLELLEEMPNGVPPEKVKSY
IYQLIKAIHWCHKNDIVHRDIKPE-------NLLISHNDVLKLCDFG--FARNLSEGNNANYTEYVATRW
YRSPELLLGAPYGKSVDMWSVGCILGELSDGQPLFPGESEIDQLFTIQKVLGPLPSEQMKLFYSNPRFHG
LRFPAVNHPQSLERRYLGILNSVLLDLMKNLLKLDPADRYLTEQCLNHPTFQTQRLL--DR---------
---SPSRSTKRKP-YHVESSTLSN-----R----NQSTKGAALQ-THHRSNSKDIQNLSVGLPRAEEG-L
PANESFLNG-NLA-GATLSP-MHTKT-YQ-AS-TQPGSSSKDLTNNNIPHLLSPKEAKSKTEFDFNID--
TKPSE-GPGT----------KY--LK-SSTR---SQQ---------------------------------
-----------NRH-SFMESSQSKAGTLQPS-EK-QSRHSY-ID-TI----P--QSS-RSPSYRTKAKSH
GALSDSKSVSNLSEARAQITETN-TS----------RYFPSSCLDLNSPT-------SPTPTRH--TDTR
TLL------SPSG-R----N---N-RNE-GTLD--SRRTTTRHSKT--MEELKLP-EH---------MDS
SHSHSLSAPHESFSYGLGYTSPFSSQQRPHRHSMYVTRDKVRAKGLDGSLS----IGQGMAARANSLQLL
SPQ------------------------------------------------PGEQLPP-EMT----VARP
SVKESSREGASSFHT-RQKSE--------------------------------GGVYHDPHSDDGTAPKE
NRHLYNDPVPRRVGSFYR---------------------------------------VPSPRPDN--SFH
ENNVSTRV---SSLPSDSSSGTNHSKRQPGFDPW-----KSPEN--I-SH-ADQLKEKEKQGFFRSMKKK
KKKTQT----------------------------------------------------------------
----------------------------------------------------------------------
-----------VPNTDGPDLL-TLQKAIHSSSTAS------SRP----------------------K---
--------------------------------EWRPEKLSDLQT--------------------------
--------Q----------------SQPLKSLRKLLHLSSS--TNHP--------ASS-D----PRFQ-P
LTAQ--Q-AKN-SFSE------IRIHPLSQA---TGGSSNI--RQE------------PTPKGR--PALQ
LP------------------------------------------------------GSSLLRYNGWKHSR
SRSSQPDEVIFLASHEKWKQ--------------------------------------------------
----------------------------------------------------------------------
----------------------------------------------------------------------
----------------------------------------------------------------------
-----------
>LOC100364794_RAT PROTID=ENSRNOP00000005061 TRANSID=ENSRNOT00000005061 GENEID=ENSRNOG00000003742 TAXID=10116
---------MNKFEILGVVGEGAYGV-----------------------------VLKCRH---------
-----------------------------------------------K----------ETHEIVAIKKFK
DSEENEEVKETTLRELKMLRTLKQENIVELKEAFRRRGKLYLVFEYVEKNMLELLEEMPNGVPPEKVKSY
IYQLIKAIHWCHKNDIVHRDIKPE-------NLLISHNDVLKLCDFG--FARNLSEGNNANYTEYVATRW
YRSPELLLGAPYGKSVDMWSVGCILGELSDGQPLFPGESEIDQLFTIQKVLGPLPSEQMKLFYSNPRFHG
LRFPAVNHPQSLERRYLGILNSVLLDLMKNLLKLDPADRYLTEQCLNHPTFQTQRLL--DR---------
---SPSRSTKRKP-YHVESSTLSN-----R----SQSTKGGALQ-THHRSNSKDIQNLSVGLPRAEEG-L
PANESFLNG-NLA-GATLSP-MHTKT-YQ-AS-TQPGSSSKDLTNNNIPHLLSPKEAKSKTEFDFNID--
PKPSE-GPGT----------KY--LK-SSTR---SQQ---------------------------------
-----------NRH-SFMESSQSKAGTLQPS-EK-QSRHSY-ID-TI----P--QSS-RSPSYRTKAKSH
GALSDSKSVSNLSEARAQITETN-TS----------RYFPSSCLDLNSPT-------SPTPTRH--TDTR
TLL------SPSG-R----N---N-RNE-GTLD--SRRTTTRHSKT--MEELKLP-EH---------MDS
SHSHSLSAPHESFSYGLGYTSPFSSQQRPHRHSMYVTRDKVRAKGIDGSLS----IGQGMAARANSLQLL
SPQ------------------------------------------------PGEQLPP-EMT----VARP
SVKESSREGTSSFHT-RQKSE--------------------------------GGVYHDPHSDDGTAPKE
NRHLYNDPVPRRVGSFYR---------------------------------------VPSPRPDN--SFH
ENNVSTRV---SSLPSDSSSGTNHSKRQPGFDPW-----KSPEN--I-SH-SDQLKEKEKQGFFRSMKKK
KKKTQT----------------------------------------------------------------
----------------------------------------------------------------------
-----------VPNTDGPDLL-TLQKAIHSSSTAS------SRP----------------------K---
--------------------------------EWRPEKLSDLQT--------------------------
--------Q----------------SQPLKSLRKLLHLSSS--TNHP--------ASS-D----PRFQ-P
LTAQ--Q-AKN-SFSE------IRIHPLSQA---SGGSSNI--RQE------------PTPKGR--PALQ
LP------------------------------------------------------G-------------
----------------------------------------------------------------------
----------------------------------------------------------------------
----------------------------------------------------------------------
----------------------------------------------------------------------
-----------
>CDKL5_RABIT PROTID=ENSOCUP00000009278 TRANSID=ENSOCUT00000010781 GENEID=ENSOCUG00000010775 TAXID=9986
MKIPNIGNVMNKFEILGVVGEGAYGV-----------------------------VLKCRH---------
-----------------------------------------------K----------ETHEIVAIKKFK
DSEENEEVKETTLRELKMLRTLKQENIVELKEAFRRRGKLYLVFEYVEKNMLELLEEMPNGVPPEKVKSY
IYQLIKAIHWCHKNDIVHRDIKPE-------NLLISHNDVLKLCDFG--FARNLSEGNNANYTEYVATRW
YRSPELLLGAPYGKSVDMWSVGCILGELSDGQPLFPGESEIDQLFTIQKVLGPLPSEQMKLFYSNPRFHG
LRFPAVNHPQSLERRYLGILNSVLLDLMKNLLQLDPADRYLTEQCLNHPTFQTQRLL--DR---------
---SPSRSAKRKP-YHVESSTLSN-----R----NQASKSTALQ-SHHRSNSKDIQNLSVVLPRADEG-L
PANESFLNG-NLA-GATLSP-MHTKS-YQ-AG-TQPGSASKDLTNNNIPHLLSPKDAKSKTEFDFNID--
PKPSE-GPGT----------KY--LK-SSSR---SQQ---------------------------------
-----------NRH-SFMESSQSKAGTLQPS-EK-QSRHSY-ID-TI----P--QSS-RSPSYRTKAKSH
GALSDSKSVSNLSETRAQVAESN-TS----------RYFPSSCLDLNSPT-------SPTPTRH--SDTR
TLL------SPSG-R----N---N-RSE-GTLD--SRRTTTRHSKT--MEELKLP-EH---------MDS
SHSHSLSAPHESFSYGLGYTSPFSSQQRPHRHSMYVTRDKVRAKGLDGSLS----IGQGMAARANSLQLL
SPQ------------------------------------------------PGEQLPP-EMT----VASP
SVKESSREGTASFHP-GQKSE--------------------------------GGVYHDPHSDDGTAPKE
NRHLYNDPVPRRVGSFYR---------------------------------------VPSPRPDN--SFH
ENNVSTRV---SSLPSESSSGTNHSKRQTAFDPW-----KSPEN--I-SH-SEQLKEKEKQGFFRSMKKK
KKKSQA----------------------------------------------------------------
----------------------------------------------------------------------
-----------VPNSDGPDLL-TLQKAIHSASTTS------SRP----------------------K---
--------------------------------EWRPEKISDLQT--------------------------
--------Q----------------SQPLKSLRKLLHLSSA--SNHP--------ASS-D----PRFQ-P
LTTQ--Q-AKN-SFSE------IRIHPLSQA---SGGSSNI--RQE------------PTPKGR--PTLQ
LP------------------------------------------------------G-------------
----------------------------------------------------------------------
----------------------------------------------------------------------
----------------------------------------------------------------------
----------------------------------------------------------------------
-----------
>CDKL5_LOXAF PROTID=ENSLAFP00000007897 TRANSID=ENSLAFT00000009421 GENEID=ENSLAFG00000009417 TAXID=9785
MKIPNIGNVMNKFEILGVVGEGAYGV-----------------------------VLKCRH---------
-----------------------------------------------K----------ETHEIVAIKKFK
DSEENEEVKETTLRELKMLRTLKQENIVELKEAFRRRGKLYLVFEYVEKNMLELLEEMPNGVPPEKVKSY
IYQLIKAIHWCHKNDIVHRDIKPE-------NLLISHNDVLKLCDFG--FARNLSEGNNANYTEYVATRW
YRSPELLLGAPYGKSVDMWSVGCILGELSDGQPLFPGESEIDQLFTIQKVLGPLPSEQMKLFYSNPRFHG
LRFPAVNHPQSLERRYLGILNSVLLDLMKNLLKLDPADRYLTEQCLNHPTFQTQRLL--DR---------
---SPSRSTKRKP-YHVESSTLSN-----R----NQASKSTALQ-SHHRSNSKDIQNLSVGLSRADEG-L
PTNESFLNG-NLA-GATLSP-MHSKT-YQ-AS-NQPGSASKDLTNNNIPHLLSPKEAKSKTEFDFNID--
PKPSE-GPGT----------KY--LK-SSSR---SQQ---------------------------------
-----------NRH-SFMESSQSKAGTLQPS-EK-QSRHSY-ID-TI----P--QSS-RSPSYRTKAKSH
GALSDSKSVSNLSEARAQIAESN-TS----------RYFPSSCLDLNSPT-------SPTLTRH--SDTR
TLL------SPSG-R----N---N-RSE-GTLD--SRRTTTRHSKT--MEELKLP-EH---------MDS
GHSHSLSAPHESFSYGLGYTSPFSSQQRPHRHSMYVTRDKVRAKGLDGSLS----IGQGMAARANSLQLL
SPQ------------------------------------------------PGEQHPP-EMT----AARS
SVKESSREGTSSFHS-RQKSE--------------------------------GGVYHDPHSDDGTAPKE
NRHLYNDPVPRRVGSFYR---------------------------------------VPSPRPDN--SFH
ENNVSTRV---SSLPSESGSGTNHSKRQTAFDPW-----KSPET--I-SH-SEQLKEKEKQGFFRSMKKK
KKKSQT----------------------------------------------------------------
----------------------------------------------------------------------
-----------VPNSDGPDLL-TLQKAIHSASTPS------SRP----------------------K---
--------------------------------EWRPEKIPDLQS--------------------------
--------Q----------------SQPLKSLRKLLHLSSA--SNHP--------ASS-D----PRFQ-P
LTTQ--Q-AKN-SFSE------IRIHPMGQA---SSGSSNI--RQE------------STPKGR--PALQ
LP------------------------------------------------------G-------------
----------------------------------------------------------------------
----------------------------------------------------------------------
----------------------------------------------------------------------
----------------------------------------------------------------------
-----------
>CDKL5_ECHTE PROTID=ENSETEP00000007574 TRANSID=ENSETET00000009320 GENEID=ENSETEG00000009318 TAXID=9371
MKIPNIGNVMNKFEILGVVGEGAYGV-----------------------------VLKCRH---------
-----------------------------------------------KA---------ETHEIVAIKKFK
DSEXXXXXXGTTLRELKMLRTLKQENIVELKEAFRRRGKLYLVFEYVEKNMLELLEEMPNGVPPDKVKSY
IYHLIKAIHWCHKNDIVHRDIKPE-------NLLISHNDVLKLCDF---FARNLSE-NNANYTEY-ATRW
YRSPELLLGAPYGKSVDMWSVGCILGELSDGQPLFPGESEIDQLFTIQKVLGPLPSEQMKLFYSNPRFHG
LRFPAVNHPQSLERRYLGILNSVLLDLMKNLLKLDPADRYLTEQCLNHPTFQTQRLL--DR---------
---SPSRSTKRKP-YHVESNTLSN-----R----NQASKSSALQ-SHHRSNSKDIQNLSVGLSRADEG-L
PANESFLNG-NLA-GATLSP-MHTKT-YQ-AS-NQPGSTSKDLTNNNIPHLLSPKEAKSKTEFDFNID--
PKPTE-GPGT----------KY--LK-SSSR---SQQ---------------------------------
-----------NRH-SFMESSQSKAGTLQPS-EK-QSRHSY-ID-TI----P--QSS-RSPSYRTKAKSH
GALSDSKSVSNLSEARAQIAEPN-TS----------RYFPSSCLDLNSPT-------SPTPTRH--SDTR
TLL------SPSG-R----N---T-RNE-GTLD--SRRTSTRHSKT--MEELKLP-EH---------MDS
SHSHSLSAPHESFSYGLGYTSPFSSQQRPHRHSMYVTRDKVRAKGLDGSMS----IGQGMAARANSLQLL
SPQ------------------------------------------------XXXQHPP-EMTVDTY----
-VKESSREGTSAHRA-RQKSE--------------------------------AGVYHDPHSDDGTAPKE
NRHLYNDPVPRRVGSFYR---------------------------------------VPSPRPDN--SFH
ENNVSTRV---SSLPSESSSGTNHSKRQTAFDPW-----KSPET--I-SH-SEQLKEKEKQGFFRSMKKK
KKKSQT----------------------------------------------------------------
----------------------------------------------------------------------
-----------VPNSDGPDLL-TLQKAIHTSSTPS------SRP----------------------K---
--------------------------------EWRPEKIPDLQT--------------------------
--------P----------------SQPLKSLRKLLHLSSA--SNHP--------APS-D----PRFQ-P
LTTQ--Q-AKN-SFSE------MRIHPMGQA---SSGSSNI--RQEPTPKGRSALQLPXXXXXX--XXXX
XX------------------------------------------------------X-------------
----------------------------------------------------------------------
----------------------------------------------------------------------
-----------------------------------------------XXXXXXX----------------
---------------------XXXXXXXXXSALLEGLNLRIQRIASFLIFKDEALVAN------------
-----------
>CDKL5_ORNAN PROTID=ENSOANP00000006401 TRANSID=ENSOANT00000006403 GENEID=ENSOANG00000004037 TAXID=9258
----------------------------------------------------------------------
-----------------------------------------------Q----------ETHEIVAIKKFK
DSEENEEVKETTLRELKMLRTLKQENIVELKEAFRRRGKLYLVFEYVEKNMLELLEEMPNGVPPEKVKSY
IYQLIKAIHWCHKNDIVHRDIKPE-------NLLISHTDILKLCDFG--FARNLSEGNNANYTEYVATRW
YRSPELLLGAPYGKSVDMWSVGCILGELSDGQPLFPGESEIDQLFTIQKVLGPLPPEQMKLFYSNPRFHG
LRFPAVNHPQSLERRYLGILSGVLLDLMKNLLKLDPADRFLTEQCLNHPSFQTQRLL--DR-CG------
--SSPSRSAKRKP-YHVESNTLSN-----R----NQAGKSGGLQ-AHHRSNSKDIQNLSVGPPRGEDG-L
QANESFLNG-NLP-GAAHSP-MHAK--------------NKDLANNNIPHLLSPKEAKPKSEFDFGVE--
QKASD-GPGS----------KY--LK-STGR---AQQ---------------------------------
-----------NRH-SLMEGSQGKTGTLQLG-EK-HGRHGY-ID-TI----P--QSS-KSPSYRTKPKSH
GSLSDSKSVSNLAEARAQIPEGNGGG----------RYFPSSCLDLNSPT-------SPTPPRP--GDNR
TLL------SPSG-R----T---N-RSD-GTLD--SRRPTPRHSKT--MEELKLP-DP---------VDG
SHSHSLSAPHESFSYGLGYTSPFSSQQRPHRHSMYVTRDKVRAKGSEGGLS----VGQGMAARANSLQLL
SPQ------------------------------------------------PGEQIPP-DMN----LTRP
PMKDPSRDGTSAFHS-RQKSE--------------------------------GGAYHDPHSDDGAASKE
NRHLYNDPVPRRVGSFYR---------------------------------------VPSPRPDN--SFH
ENNVSSRV---SSLPSDSSSATNHSKRQTTFDPW-----KSPEN--V-SH-SEQLKDKEKQGFFRSMKKK
KKKSQT----------------------------------------------------------------
----------------------------------------------------------------------
-----------VPNTDGQDLL-AFQKAMHPSNHQS------SRP----------------------K---
--------------------------------EWRPEKMTDLQA--------------------------
--------H----------------TQPLKSLRKLLHLSST--SNHP--------PSS-D----ARFQ-P
IPSQ--P-AKG-SFSE------VRIHPLSQASSSSSGSGNV--RQE------------GAPKGR--PTLQ
LP------------------------------------------------------G-------------
----------------------------------------------------------------------
----------------------------------------------------------------------
----------------------------------------------------------------------
----------------------------------------------------------------------
-----------
>CDKL5_CHICK PROTID=ENSGALP00000026624 TRANSID=ENSGALT00000026675 GENEID=ENSGALG00000016529 TAXID=9031
MKIPNIGNVMNKFEILGVVGEGAYGV-----------------------------VLKCRH---------
-----------------------------------------------K----------ETHEIVAIKKFK
DSEENEEVKETTLRELKMLRTLKQENIVELKEAFRRRGKLYLVFEYVEKNMLELLEEMPNGVPPEKVKSY
IYQLIKAIHWCHKNDIVHRDIKPE-------NLLISHNDVLKLCDFG--FARNLSEGSNANYTEYVATRW
YRSPELLLGAPYGKAVDMWSVGCILGELSDGQPLFPGESEIDQLFTIQKVLGPLPAEQMKLFYSNPRFHG
LRFPAVNHPQSLERRYLGILSGVLLDLMKNLLKLDPADRYLTEQCLNHPSFQTQRLL--DR-CG------
--SSPSRSAKRKP-YHVDSNTLSN-----R----NQASKSSALQ-SHHRSNSKDIQTLGIGGPR-EEG-L
PANESFLNG-NLS-GAAHSP-MHAK---K-SS-NQPGSGNKDLANNNMPHLLSPKETKAKTEFDFNVD--
PKSSD-GPGT----------KY--LK-SNTR---SQQ---------------------------------
-----------NRH-SFMETSQSKTGTLQPG-DK-HSRHSY-ID-TI----P--QSS-KSPSYRTKSKSH
GVLTDSKSVGNLSEARAQAAEPN-SS----------RYFPSSCMDLNSPT-------SPTAPRH--SDNR
TLL------SPSG-R----N---N-RSE-GTLD--TRRPSTRHSKT--MEELKLP-DH---------MDG
SHSHSLSAPHESFSYGLGYTSPFSSQQRPHRHSMYVSRDRVRSKGSEGGLS----VGQGMAARANSLQLL
SPQ------------------------------------------------QSDQIPS-ETN----LTRP
PVKDSSRDVTAAFHS-RRKSE--------------------------------GGAYHDPHTEDGASTKE
NRILYNEAVPRRVGSFYR---------------------------------------VPSPRPDS--TYI
ENNVSNRA---SVLPADSSTVANHSKRQTTFDTW-----KSPEN--LNSH-SEQLKEKEKQGFFRAIKKK
KKKSQT----------------------------------------------------------------
----------------------------------------------------------------------
-----------MPGTDGQDLL-ALQKAIHSSNHQS------SRQ----------------------K---
--------------------------------DWHPEKMTEIQP--------------------------
--------H----------------SQPLKSLRKLLHLS----SNHP--------IPA-E----PRFQ-P
LPSQ--P-AKP-AFSE------VRIHPMSQ--SSSSGSSNA--RQE------------PQPKSR--PTLQ
IP--------------------------------------------------------------------
----------------------------------------------------------------------
----------------------------------------------------------------------
----------------------------------------------------------------------
----------------------------------------------------------------------
-----------
>CDKL5_MELGA PROTID=ENSMGAP00000015547 TRANSID=ENSMGAT00000016504 GENEID=ENSMGAG00000014674 TAXID=9103
----------------------------------------------------------------------
-----------------------------------------------Q----------ETHEIVAIKKFK
DSEENEEVKETTLRELKMLRTLKQENIVELKEAFRRRGKLYLVFEYVEKNMLELLEEMPNGVPPEKVKSY
IYQLIKAIHWCHKNDIVHRDIKPE-------NLLISHNDVLKLCDFG--FARNLSEGSNANYTEYVATRW
YRSPELLLGAPYGKAVDMWSVGCILGELSDGQPLFPGESEIDQLFTIQKVLGPLPAEQMKLFYSNPRFHG
LRFPAVNHPQSLERRYLGILSGVLLDLMKNLLKLDPADRYLTEQCLNHPSFQTQRLL--DR-CG------
--SSPSRSAKRKP-YHVDSNTLSN-----R----NQASKSSALQ-SHHRSNSKDIQTLGVGGSR-EEG-L
PANESFLNG-NLS-AAAHSP-MHAK---K-SS-NQPGSGNKDLANNNMPHLLSPKETKAKTEFDFNVD--
PKSSD-GPGT----------KY--LK-SNTR---SQQ---------------------------------
-----------NRH-SFMETSQSKTGTLQPG-DK-HSRHSY-ID-TI----P--QSS-KSPSYRTKSKSH
GVLTDSKSVGNLSEARAQAAEPN-SS----------RYFPSSCMDLNSPT-------SPTAPRH--SDNR
TLL------SPSG-R----N---N-RSE-GTLD--TRRPSTRHSKT--MEELKLP-DH---------MDG
SHSHSLSAPHESFSYGLGYTSPFSSQQRPHRHSMYVSRDRVRSKGSEGGLS----VGQGMAARANSLQLL
SPQVQHK-SLTR-SVGSSREDCTEDTNR-----------------------QSDQIPS-ETN----LTRP
PVKDSSRDVTAAFHS-RRKSE--------------------------------GGAYHDPHTEDGASTKE
NRILYNEAVPRRVGSFYR---------------------------------------VPSPRPDS--TYI
ENNVSNRA---SVLPADSSTVANHSKRQTTFDTWFR---KSPEN--LNSH-SEQLKEKEKQGFFRAIKKK
KKKSQT-----------------------------------------VNTSSSNLDQILLQHTPFRLGGR
EHFKSLANMSRQRKKEIGRDRGFT----------------------------------------------
------------------------QKAIHSSNHQS------NRQ----------------------K---
--------------------------------DWHPEKMTEIQP--------------------------
--------H----------------SQPLKSLRKLLHLS----S---------------E----PRFQ-P
LPSQ--P-AKP-AFSE------VRIHPMSQ--SSSSSSSNA--RQE------------PQPKSR--PTLQ
IP------------------------------------------------------S-------------
----------------------------------------------------------------------
----------------------------------------------------------------------
-----------------------------------------------QLEPTWHVSPVNRSASDGPPY-S
EQP-SKSGQNGHTYNRTNRSRMPNLNDLKETAL-------------------------------------
-----------
>CDKL5_TAEGU PROTID=ENSTGUP00000008001 TRANSID=ENSTGUT00000008086 GENEID=ENSTGUG00000007769 TAXID=59729
MKIPNIGNVMNKFEILGVVGEGAYGV-----------------------------VLKCRH---------
-----------------------------------------------K----------ETHEIVAIKKFK
DSEENEEVKETTLRELKMLRTLKQENIVELKEAFRRRGKLYLVFEYVEKNMLELLEEMPNGVPPEKVKSY
IYQLIKAIHWCHKNDIVHRDIKPE-------NLLISHNDVLKLCDFG--FARNLSEGSNANYTEYVATRW
YRSPELLLGAPYGKAVDMWSVGCILGELSDGQPLFPGESEIDQLFTIQKVLGPLPAEQMKLFYSNPRFHG
LRFPAVNHPQSLERRYLGILSGVLLDLMKNLLKLDPADRYLTEQCLNHPSFQTQRLL--DR-SG------
--SSPSRSAKRKP-YHADSNTLSN-----R----NQASKSSALQ-SHHRSNSKDLQTLGAGGPR-EEG-L
PANESFLNG-NLP-GPAPSP-MHAK---K-PS-NTPGSGNKDIANNNMPHLLSPKEPKGKTEFDFNVD--
TKSSD-GSGT----------KY--MK-SNTR---SQQ---------------------------------
-----------NRH-SFMETSQSKTGTLQPG-DK-HSRHSY-ID-TI----P--QSS-KSPSYRTKSKSH
GVLTDSKSVGNLSEARAQAAEPN-TS----------RYFPSSCMDLNSPT-------SPSAPRH--GDNR
TML------SPSA-R----N---N-RSE-GTLD--TRRPPTRHSKT--MEELKLP-DH---------VDG
SHSHSLSAPHESFSYGLGYTSPFSSQQRPHRHSMYVSRDRVRSKGSEGGLS----VGQGMAARANSLQLL
SPQ------------------------------------------------------------------P
P-------------------EMLQRKCVVIWSASFVCSRRPQKYLHEIKQQNQGGAYHDPHTEDGASTKE
NRILYNDPVPRRVGSFYR---------------------------------------VPSPRPES--TYI
ENNVSNRA---SVLPADSSTVTNHPKRQTTFDTW-----KTPEN--LNSH-SEQLKEKEKQGFFRAIKKK
KKKSQN----------------------------------------------------------------
----------------------------------------------------------------------
-----------MPNTEGQDLL-ALQKAIHSSNHQS------SRQ----------------------K---
--------------------------------DWHPEKMTEIQP--------------------------
--------H----------------SQPLKSLRKLLHLS----SNHP--------VAA-E----PRFQ-P
LPSQ--P-AKA-SFPE------VRIHPMSQ--SSSSGSSNV--RPE------------PQPKSR--PTLQ
IP--------------------------------------------------------------------
----------------------------------------------------------------------
----------------------------------------------------------------------
----------------------------------------------------------------------
----------------------------------------------------------------------
-----------
>cdkl5_XENTR PROTID=ENSXETP00000047159 TRANSID=ENSXETT00000047159 GENEID=ENSXETG00000021807 TAXID=8364
----------------------------------------------------------------------
----------------------------------------------------------------------
---ENEEVKETTLRELKMLRTLKQENIVELKEAFRRRGKLYLVFEYVEKNMLELLEEMPNGVPPEKVTNY
IYQLIKAIHWCHKNDIVHRVIKQEEYITLSASLL--QAAI-----FG--FARNLSEGSNANYTEYVATRW
YRSPELLLGAPYGKAVDMWSVGCILGELSDGQPLFPGESEIDQLFTIQKVLGPLPAEQMKLFYSNPRFHG
MRFPAVNHPQSLERRYLGIISSVLLDLMKNLLKLNPSDRFLTEQSLNHPAFQTQRLL--DR-GG------
--TSPSRSSKRKT-HHSESN-LAS-----R----KQSSKSSSVQ-PHHRSNSKDTQTLSVGPKRNEET-H
PPNETFING-AHP-AGSHSPTVHQK---K-NS--QSGSGNKDPASNNLPHLLSPKDAKSKNEFDFSPE--
QKTSD-VPGA----------KY--TK-SNSR---SQH---------------------------------
-----------NRH-SFME---GKTGSWQPS-EK-HTRHSY-ID-TI----P--QSSKKSSSYMNYSKNH
GVLTDSKSVGNLSEARGQILEPN--S----------RYFPSSCHDLNSPT-------SPAAPRH--GDSR
GML------SPSG-R----T---N-RKE-GTLE--SRRPTTKHSRT--MEELKLP-DQ---------MDS
SHSHSLSAPHESFSYGLGYTSPFSSQQRPHRHSMYVSRDRVRVKGTDAALN----VGQGMASRASSLQLL
SPQ------------------------------------------------QGDQVPS-EVT----HSRT
LAKDPNRDGAASFHT-RQKTE--------------------------------GGPYHDSHPDDGAASKE
NRHIYSDTVPRRVGSFYR---------------------------------------VPSPRPEG--TFH
DNTVSSRG---SSHPVDSSGVTNHSKRQTTFDHW-----TGAEK----SH-SEQMKEKEKQGFFRVIKKK
KKKSQT----------------------------------------------------------------
----------------------------------------------------------------------
-----------MPSADGQDHL-PVQKGVHSSSHKS------SRQ----------------------K---
--------------------------------EWRPDKMAEIHS--------------------------
--------H----------------SQPLKSLWKLLHPSSS--SNHP--------MPP-D----PRFQ-P
LPNQ--P-PKTPSFPE------ARIHPVGQ--TSSSG--GVVHRQD------------PQPKSR--QGLQ
IP------------------------------------------------------G-------------
----------------------------------------------------------------------
----------------------------------------------------------------------
-----------------------------------------------QA---------------------
----------------------------------------------------------------------
-----------
>CDKL5_LATCH PROTID=ENSLACP00000009601 TRANSID=ENSLACT00000009675 GENEID=ENSLACG00000008468 TAXID=7897
MKIPDIGNVMNKFEVLGIVGEGAYGV-----------------------------VLKCRH---------
-----------------------------------------------K----------ETNEIVAIKKFK
DSEENEEVKETTLRELKMLRTLKQENIVELKEAFRRRGKLYLVFEYVEKNMLELLEEMPNGVPPEKVRNY
IYQLIKAIHWCHKNDIVHRDIKPE-------NLLISHNDILKLCDFG--FARNLSEGSNANYTEYVATRW
YRSPELLLGAPYGKAVDMWSVGCILGELSDGQPLFPGESEIDQLFTIQRVLGPLSPEQMKLFYSNPRFHG
LRFPAVSHPQTLERRYLGIISGVLLDLMKNLLKLNPSERYLTDQSLNHPAFQTQRLL--DR-SG------
-SSSPARSTKRKP-YHVENSTLSN-----R----NPASKGAGMQ-SHHRSNSKDMQTLGVGLQRGEDV-L
-PTDNFLNG-NVV-VNALSPTLHTKN-YQ-QT-NRTPSGNRDL-GGNLPHLLSPKEAKAKTEFDFNLD--
QKGSD-GPGA----------KY--LK-STSR---SQQ---------------------------------
-----------SRH-TFLDVSQNRTGTLQPS-DK-HNRHSY-ID-AVQGNMS--QSSKNVMSYLTLSKSH
GVLTDSKSVGNLIDARGQLEEAN--S----------RYFPSSCLDLNSST-------SPTPPRH--TDNR
TSL------SPSG-R----N---NARMD-GTLD--SRRPPNRHPKT--IEEIKLPAEH---------IEG
GHSHSLSAPHESFPYGLGYTSPFSSQQRPHRHSMYVTRDRPRVQGSEGGLN----IGQGMPSRASSLQLL
SPQLQHR-TLARHSVGSSREDCADDISR-----------------------N-DQ-PSVEMS----HSRP
SIKDSNRDNAALFQ--RQKSE--------------------------------VGGYHENHPEDGSSTKE
NRHMYTDAVPRRVGSFYR---------------------------------------VPSPRPEG--TFL
DNPVSTRA---PVLPPEGNSMSNHSKRQTTFDSW-----KTSEDVVL-SNPPEPGKGKEKQGFFRAIKKK
KKKSQTTEHDDGENPSIKKCLFPLFSSKSHLKHSSSLKKLPVVTLPM-----------------------
----------------------------------------------------------------------
-----------MPSSDGQDRL-ALQKAIRSSSHQS------SRQ----------------------K---
--------------------------------DWRSEKAADVQT--------------------------
--------Q----------------SQPLKSLRKLLHLSTP--SNHS--------APS-E----LRFQ-P
LPSQ--P-TKA-SFTE------GRIHPAVQ--TPST---NV--RQD------------TQSKSR--QTFQ
LP------------------------------------------------------G-------------
----------------------------------------------------------------------
----------------------------------------------------------------------
-----------------------------------------------QLEPTWHIPPVNRTGSDGTSF-S
DQMASKTGQNGHSFNRTGRLRMPNLNDLKETAL-------------------------------------
-----------