>Tge -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -----------xxxxxxxxx------------------------------ -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ---------------------------YTDTSAEWLSLYESPEVQNIPKE VARLW--------------------------KQLRPLYLQLHAYVRRKLY LKYGVSVVDPRRGIPAHLLGNMWGQIWDNLLNISQPFPDTPSPNVTEALK QQVIILILRAxxxxxSSNFE------xxxxPGTDVYSPETLHVPDDSRLx xRFxGFTTRKMFQxxx-----------------xFFVSLNLSAMPPLFWR NSILEKPxxxxRMNCHxxxWDFMDRKDFRILQCSDVSLRSFLTAHHEMGH IENFVLYKDQPPTYREGANPGFDEAIGDVITLSVMTPKHLKKIGLLSDDE HVESYEANINHLYSVALRKLTLLPSAYVIDLWRWAVFQGSVTPRNYNCHW WYLREKYQGVVPPEKRSEEQFDPGSKFHVAANVPYIRYFISAILEFQMHR HMCEVTDEYDPHDTSKPLHSCDIYQKQQAGALLREVMSMGSSRPWPEALK VITGSRCMDASALREYLLPLEHWLTVENEKTGELIGWEHTG--------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ------------xxSATSGxxxMTVAFIIFAVATxLHLWESQCWQLLxxx xxxxRPNxxxxxxxRHLVHTVEVQMLDRLTGSNNCSH------------- -------------------------------------------------- --------------------------LVMN-------------------- ----------------------------------------------QDPN D---------------------------------------------- >Tpa -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ---------------------MWGQIWDNLLNISQPFPDTPSPNVTEALK QQ------------------------------------------------ ----GFTTRKMFQxxx-----------------xFFVSLNLSAMPPLFWR NSILEKPxxxxRMNCHxxxWDFMDRKDFRILQCSDVSLRSFLTAHHEMGH IENFVLYKDQPPTYREGANPGFDEAIGDVITLSVMTPKHLKKIGLLSDDE HVESYEANINHLYSVALRKLTLLPSAYVIDLWRWAVFQGSVTPRNYNCHW WYLREKYQGVVPPEKRSEEQFDPGSKFHVAANVPYIRYFISAILEFQMHR HMCEVTDEYDPHDTSKPLHSCDIYQKQQAGALLREVMSMGSSRPWPEALK VITGSRCMDASALREYL--------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ----------------------------------------------- >Tte x------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ------------------------------------AANARSSTYERLQH ERVNVFPRSIMSD--------------PDLRRKLKKMSSLGISALPDQQL LR------------------------------------------------ -------NPEELKHAWLEWRRVSGQRMRSLYAEYVELSNMASRLNxxxx- --------xxxxxxxxxxxx------------------------------ -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ---------------------------YTDTSAEWLSLYESPEVQDIPKE VARLW--------------------------KQLRPLYLQLHAYVRRKLY LKYGVSVVDPRRGIPAHLLGNMWGQIWDNLLNISQPFPDTPSPNVTEALK QQVIILILRAxxxxxSSNFExxRKMFx----------------------- ----GFTTRKMFQxxx-----------------xFFVSLNLSAMPPLFWR NSILEKPxxxxRMNCHxxxWDFMDRKDFRILQCSDVSLRSFLTAHHEMGH IENFVLYKDQPPTYREGANPGFDEAIGDVITLSVMTPKHLKKIGLLSDDE HVESYEANINHLYSVALRKLTLLPSAYVIDLWRWAVFQGSVTPRNYNCHW WYLREKYQGVVPPEKRSEEQFDPGSKFHVAANVPYIRYFISAILEFQMHR HMCEVTDEYDPHDTSKPLHSCDIYQKQQAGALLREVMSMGSSRPWPEALK VITGSRCMDASALREYLLPLEHWLTVENEKTGELIGWEHTG--------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ------------xxSATSGxxxMTVAFIIFAVATxLHLWESQCWQLLxxx xxxxRPNxxxxxxxKHLVHTVEVQMLDRLTGSNNCSH------------- -------------------------------------------------- --------------------------LVMD-------------------- ----------------------------------------------QDPN D---------------------------------------------- >Tce -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -----------x-------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ----xxxxxxxxxxxxxxxxxxxxxxxxxxxxx------QLHAYVRRKLY LKYGVSIVDPRRGIPAHLLGNMWGQIWDNLLNISQPFPDTPSPKVTEALK Qx------------------------------------------------ ----GFxxRKMFQxxx-----------------xxxxxxxLSAxxxLFxx xxxxxxxxxxxxxxxxxxxxxxxxxxxFRILQCSDVSLRSFLTAHHEMGH IENFVLYKDQPPTYREGANPGFDEAIGDVITLSVMSPKHLKKIGLLSDDE HVGSYESNINHLFSVALRKLTLLPFAYVIDLWRWAVFQGSVTPRNYNCHW WYLREKYQGVVPPEKRSEEQFDPGSKFHVAANVPYIRYFISAILEFQMHR HMCEVVGEYDPNDTRKPLHSCDIYQKQQAGTLLRRVMSMGSSQPWPEALK VITGSRCMDASALREYLLPLEHWLTVENEKTGELIGWEHTG--------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ------------xxxxxxxxxxMTxxxxxxxxATFLHLWESQxxxxLxxx xxxxHPNxxxxxxxRHLVHTVEVQMLDRLTGSKNCSH------------- -------------------------------------------------- --------------------------LVMD-------------------- ----------------------------------------------QDKI N---------------------------------------------- >Tsi -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -----------xx-----xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx xxx----------------------------------------------- -------------------------------------------------- ----------xxxxxx---------------------------------- ----xxxxxxxxx------------xxYTDASAQWLSLYESPEVQDIPKE VARLW--------------------------NQLRPLYLQLHAYVRRKLY LKYGVSIVDQRRGIPAHLLGNMWGQSWDNLLNISQPFPDTPSPKVTEALK QQ------------------------------------------------ ----GFTSRKMFQxxx-----------------xFFVSLNLSAMPPLFWR NSILEKPxKRRRVNCHSSAWDFMDRKDFRILQCSDVSLRSFLTAHHEMGH IENFVLYKDQPPTYREGANPGFDEAIGDVITLSVMTPKHLKKIGLLSDDE HVESYEASINHLYSVALRKLTLLPFAYVIDLWRWAVFQGSVTPRNYNCHW WYLREKYQGVVPPEKRSEEQFDPGSKFHVAANVPYIRYFISAILEFQMHR HMCEVVGEYDPHDNRKPLHSCDIYQKQQAGTLLREVMSMGSSRPWPEALK VITGSRCMDASALREYLLPLEHWLTVENEKTGEFIGWEHTGxxxxxxxxx xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx xxxxxxxx----------xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx xxxxxxxGHCxxxxxxxxxxxxGSAxxxxxxGxx---------------- -------xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx xxxxxxxxLxxxxxxxxxxxxx---------------------------- -------------------------------------------------- -------------------------------------------------- ----------------x-----------xxxxxxxxxxSGRKFTVxxxxx xxxxxxGxxYxxDDSVTSGxxGMTVAFIIFAVATxLHLWESHCWQLLxxx xxxxRPNxxxxxxxRHLVHTVEVQMLDRLTGSKNCSH------------- -------------------------------------------------- --------------------------LVMN-------------------- ----------------------------------------------QDAI N---------------------------------------------- >Tps -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ------------------------------------------------xx xxxxxxxxxxxxxxxxxxxx------------------------------ -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ---------------------------YTDASAQWLSLYESPEVQDIPKE VARLW--------------------------KQLRPLYLQLHAYVRRKLY LKYGVSIVDPRRGIPAHLLGNMWGQIWDNLLNISQPFPDTPSPKVTEALK QQVIILILRAxxxxxSSNFExxRKMFx----------------------- ----GFTSRKMFQxxx-----------------xFFVSLNLSVMPPLFWR NSILEKPxKRRRVNCHSSAWDFMDRKDFRILQCSDVSLRSFLTAHHEMGH IENFVLYKDQPPTYREGANPGFDEAIGDVITLSVMTPKHLKKIGLLSDDE HVESYEASINHLYSVALRKLTLLPFAYVIDLWRWAVFQGSVTPRNYNCHW WYLREKYQGVVPPEKRSEEQFDPGSKFHVAANVPYIRYFISAILEFQMHR HMCEVVGEYDPHDTRIPLHSCDIYQKQQAGTLLREVMSMGSSRPWPEALK VITGSRCMDASALREYLLPLEHWLTVENEKTGEFIGWEHTGxxxxxxxxx x---------------------xxxxxxxxxxxxxxxxxxxxxxxxxxxx xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx------------------ ----xxxGHCxxxxxxxxxxxxGSAxxxxxxGxxxxxxxxxxxxxxxxxx xxxxxxxx------------------------------------------ -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ------------EDSATSGxxGMTVAFIIFAVATxLHLWESHCWQLLxxx xxxxRPNxxxxxxxRHLVHTVEVHMLDRLTGSKNCSH------------- -------------------------------------------------- --------------------------LVMD-------------------- ----------------------------------------------QDAI N---------------------------------------------- >Tms MIISNVYYxxxxxxVAT--------------------------LTFVEST SMRTKYLTDKPQSSSGDSQYDVEARFALEKMAQEFYFGARDNSSEEWQRG TGRFINKERLDIAEESKNLMPIVVWQEKADEKTKMDEEESNMAEDKPKIV KEKNKMVEDKPKMNExxPSMAERKSKIAxDKSKTAKEKMKMVKEKPKTVK GVNLKSPAxxxxxxMRFLAEEEPKMAEEKxxxxxxxxxxxxxMWQEEAMR FLAEEEPKMAEEANLKALAAWNYAARMTKKNKDKMDAANARSSTYERVQH ERVNLFPRSIMSD--------------PDLRRKLKKMSSLGISAIPDEQL LRFNDILVEMQDIYVSGKGCSYTEPTQY--------------------LN GVLASSQNPEELKHAWLEWHRVSGQRMRSLYAEYVELSNMGARxx----- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- --------------------------xYTDASAQWLSLYESPEVQDIPKE VARLW--------------------------KQLRPLYLQLHAYVRRKLY LKYGVSIVDPRRGIPAHLLGNMWGQIWDNLLNISQPFPDTPSPKVTEALK QQ------------------------------------------------ ----GFTSRKMFQxxx-----------------xFFVSLNLSAMPPLFWR NSILEKPxxxxRVNCHxxxWDFMDRKDFRILQCSDVSLRSFLTAHHEMGH IENFVLYKDQPPTYREGANPGFDEAIGDVITLSVMSPKHLKKIGLLSDDE HVESYESNINHLFSVALRKLTLLPFAYVIDLWRWAVFQGSVTPRNYNCHW WYLREKYQGVVPPEKRSEEQFDPGSKFHVAANVPYIRYFISAILEFQMHR HMCKVVGEYDPNDTRKPLHSCDIYQKQQAGTLLRRVMSMGSSQPWPEALK VITGSRCMDASALREYLLPLEHWLTVENEKTGELIGWEHTG--------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ------------xxxxxxxxxxMTxxxxxxxxATxxHLWESQxxxxLxxx xxxxRPNxxxxxxxRHxxxxxxxQxxDRLTGSKNCSH------------- -------------------------------------------------- --------------------------LVMD-------------------- ----------------------------------------------xDAI N---------------------------------------------- >Tcm MII-------------xLRYFxxxxxxFDRTVSLxxxxxxVTMLTFVEST STRTKYFTDKPQSSSGDSQYDVEARFALEKMAQEFYFGARDNSSEEWQRV TGRFINKERLDIAEES-NLMPIVMWQEEADENTKMDEEESNMAEDKPKIA EEKNKMVEDKPRMNDE-PSMAERNPKIAxDKSKTAKEKTKIAEEKPKTDK GASLKSPA----------------------------------MWQEEAMR FLAEEEPKMAEEANLKALAAWNYAARMTKKNKAKMDAANARSSTYERVQH ERVNVFPRSIMSD--------------PDLRRKLKKMSSLGISALPDEQL LR-------------------------xERxxxxxDxFDLVL-----DLD GVLASSQNPEELKHAWLEWHRVSGQRMRSLYAEYVELSNMAARLN----- -------------------------------------------------- --S----------------------------------------------- -------PGxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxRSxxxxxxx xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx xxxxx---------------------xYTDASAQWLSLYESPEVQDIPKE VARLW--------------------------KQLRPLYLQLHAYVRRKLY LKYGVSIVDPRRGIPAHLLGNMWAQSWDNLLNISQPFPDSPSPKVTEALK QQ------------------------------------------------ ----GFTSRKMFQxxx-----------------xFFVSLNLSAxPPLFWR NSILEKPxKRRRVNCHSSAWDFMDRKDFRILQCSDVSLRSFLTAHHEMGH IENFVLYKDQPPTYREGANPGFDEAIGDVITLSVMTPKHLKKIGLLSDDE HVESYEASINHLYSVALRKLTLLPFAYVIDLWRWAVFQGSVTPRNYNCHW WYLREKYQGVVPPEKRSEEQFDPGSKFHVAANVPYIRYFISAILEFQMHR HMCEVVGEYDPHDNRKSLHSCDIYQKQQAGTLLREVMSMGSSRPWPEALK VITGSRCMDASALREYLLPLEHWLTVENEKTGEFIGWEHTGxxxxxxxx- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ---------------------xxxxxxxxxxxxxxxxxxxxxxxxxxxxx xxxxxxxxxxxxxxxxxxxxxLxxxxxxxxxxxxxxxxxxxxxxxxxxxx xxxxxWEEVKPLYELMHAYGxxxLAMFRLAEDFYQSMNMSGMPPExxAxS VLEELPDRIVICQPSAWDFCNRRDYRIKM--------------------- -------------------------------------------------- ----------------------------------CTxxxxxxxxxxxxxx xxIQYFLHYRHLPKAFRDGANPGxxxxVGEAIALxxxxxxxxxxxxxxQx xADxxxxDINYxxxxxxDKLAFLxxxxxxxxxxxxxxxxxVGKEQYNCHx xxxxxxYxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx------------- -xxxxTKYYIxxxxxxxxxxxxxxxxxxxxQTKRExxxxxxNIxxxx >Tdi x------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ------------xxxxxxxxxxxxxxxxx--------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ---------------------------YTDASAQWLSLYESPEVQDIPKE VARLW--------------------------KQLRPLYLQLHAYVRRKLY LKYGVSIVDPRRGIPAHLLGNMWGQIWDNLLNISQPFPDTPSPKVTEALK QQ------------------------------------------------ ----GFTSRKMFQxxx-----------------xFFVSLNLSVxPPLFWR NSILEKPxKRRRVNCHSSAWDFMDRKDFRILQCSDVSLRSFLTAHHEMGH IENFVLYKDQPPTYREGANPG----------------------------- -------------------------------------------------- ---QEKYQGVVPPEKRSEEQFDPGSKFHVAANVPYIRYFISAILEFQMHR HMCEVVGEYDPHDTRIPLHSCDIYQKQQAGTLLREVMSMGSSRPWPEALK VITGSRCMDASALREYLLPLEHWLTVENEKTGEFIGWEHTGxxxxxxxxx x---------------------xxxxxLxxxxxxxxxxxxxx-------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ---------------------------------xxxxxxxxxxxxxxxxx xxxxxxxxxQxxxxxxxxxxxLxxxxxxxxxxxxxxxxxxxxxxxxxxxx xxxxxWEEVKxxxELMHAYGxxxLxxxRLAEDFYQSMNMSGMPPEFWAGS VLEELPDRIVICQPSAWDFCNRRDYRIKM--------------------- -------------------------------------------------- ----------------------------------CTxxxxxxxxxxxxxx xxIQYFLHYRHLPKAFRDGANPGFHxxVGEAIALxxxxxxxxxxxxxxQN SADxxxxDINYxxxxxxxxxxxxxxxxxxxxxxxxxxxxxVGKEQYxxxx xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxVKxxxxKNx x---------------------------------------------- >Tbi xxISNVYYNVLIFGVTT--------------------------LTFVEST SMRTKYFTDKPQSSSGDSQYDVEARSALEKMAQEFYFGARDNSSEEWQRG TGRFINKERLDIAEEA-NLKPIVVWQMEAEENTKIDEEELNMAEDRPKIA EEKTKMIEGKPRMDE--------------DKSKTAKEITKIAEGKPKTVK GVNLKTPA----------------------------------MWQEEAMR FLAEEEPRMAEEANLKALAAWNYAARMTKKNKAKMDAANARSSTYERLQH ERVNVFPRSIMSD--------------PDLRRKLKKMSSLGISALPDQQL LRFNDILVEMQEIYVSGKGCSYTEPTQ--------------CNQSLADLD GVLASSQNPEELKHAWLEWHRVSGQRMRSLYAEYVELSNMASRLx----- -------------------------------------------------- --SQSxxxxxxxxxxxxxxxxxxxxxxxxxxxxxSGRVDKMDMxxxxxxx xxxxxxxx------------------------------------------ -------------------------------------------------- ---xx-------xxxxRxxxxxxxxAYYTDTSAEWLSLYESPEVQDIPKE VARLW--------------------------KQLRPLYLQLHAYVRRKLY LKYGVSVVDPRRGIPAHLLGNMWGQIWDNLLNISQPFPDTPSPNVTEALK QQVIILILRAxxxxxSSNFExx---------------------------- --------xxxxxxxxxxxxxxxxxxxxxxxxxxxxI------------- ----------------------------RILQCSDVSLRSFLTAHHEMGH IENFVLYKDQPPTYREGANPGFDEAIGDVITLSVMTPKHLKKIGLLSDDE HVESYEANINHLYSVALRKLTLLPSAYVIDLWRWAVFQGSVTPRNYNCHW WYLREKYQGVVPPEKRSEEQFDPGSKFHVAANVPYIRYFISAILEFQMHR HMCEVTDEYDPHDTSKPLHSCDIYQKQQAGALLREVMSMGSSRPWPEALK VITGSRCMDASALREYLLPLEHWLTVENEKTGELIGWEHTG--------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ------------xxxxxxxxxxxxxxxxxxxxATxxxxxxxxxxxxLxxx xxxxxxxxxxxxxxxHLVHTVEVQMLDRLTGSNNCSH------------- -------------------------------------------------- --------------------------xVMD-------------------- ----------------------------------------------xDPN x----------------------------------------------