>Tge x------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ----------------xxxxxxxxxxxxxxEVRYASVESVCQLSLDNPQF AHMSLDFLVDMFNDEIEEVRIKAIDSLTRISRHIVLREDQLETILGALK- -------------------------------------------------- ----------------------------DFSMDVREGLHKMLASCRLSSK NCLQMCVESLLENLKKYPM------------------------------- -------------------------------------------------- --------------------------------------------DRRSTW HCLQKIGQSHPELTLPLVPELLAIHPFFDTPEPDVEDPA----------- ------------------------------YVCILILVFNAAQQSPTMLQ LFEEHTLKHYSYLRDTMPTLVPALKVVxxxxxxxxxxxxxxxx------- -----LLGSSRPADPAPLSTGSAQYLSAILARIETAPSSCVRRELMEACR HDLSRLATIDRAIPGALQFSALYISSQLLMMDILSNKLWSNPSALASQQG NVVKNCISQLLSQCLKLQHLYVGLNTEDLSCVKQFKLKALALQLVYIVRG SNFSALALCEHFLETVEDTQRYLSEHEVQPEVFTSALFKELGLLEDTKPG PVARCLLPLLQVSTPAPLPHTNI--------------------------- -------------------------------------------------- ----------------------------------------EIRSSMAVIS EPTGDLETALKFTAGLVLGVHCDALLHNIQDISTLRIKVKYPDQQTHLLV PRPTDLRPLEPPDHRLLTTVLLSHHVWTEACIVEVSLALDVARAESGLAG RKVLSSGSVRSDDPWVLDLCRPVK-------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------VLVSPKP IKRGI >Tbi x------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ----------------xxxxxxxxxxxxxxEVRYASVESVCQLSLDNPQF AHMSLDFLVDMFNDEIEDVRIKAIDSLTRISRHIVLREDQLETILGALK- -------------------------------------------------- ----------------------------xxxxxxxxxxxxxxxxxxxxxx xxxxxxVESLLENLKKYPMxxxxxxxxxxxxxxxxxxxxKLVYSMACLGN WRFTSFxxxxxxxxSxxxxYxxxHSTLCALHDQLQFVALRVSLCMYTPLS YLxxxxxxLVAVLGCxxxxxxxxxxxxxxxxxxxxxxxxxxxxxDRRSTW HCLQKIGQSHPELTLPLVPELLAIHPFFDTPEPDVEDPACILHSHTL--- --ELELELFYNIQH---------------LYVCILILVFNAAQQSPTMLQ LFEEHTLKHYSYLRDTMPTLVPALKVVxxxxxxxx--------------- -----LLGSSRPADPAPLSTGSAQYLSAILARIETAPSSCVRRELMEACR HDLSRLATIDRAIPGALQFSALYISSQLLMMDILSNKLWSNPSALASQQG NVVKNCISQLLSQCLKLQHLYVGLNTEDLSCVKQFKLKALALQLVYIVRG SNFSALALCEHFLETVEDTQRYLSEHEVQPEVFTSALFKELGLLEDTKPG PVARCLLPLLQVSTPAPLPHTNI--------------------------- -------------------------------------------------- ----------------------------------------EIRSSMAVIS EPTGDLETALKFTAGLVLGVHCDALLHNIQDISTLRIKVKYPDQQTHLLV PRPTDLRPLEPPDHRLLTTVLLSHHVWTEACIVEVSLALDVARAESGLAG RKVLSSGSVRSDDPWVLDLCRPVK-------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------VLVSPKP IKRGI >Tte xxAVLKKRALAxYSQTIQ-----------------------EEPPKPAKK LRLVKKLTLGNSAIVYIGLLEKSKSSNDALQVLVRIADCLKFEEEDIPDV IKKxxxxFQYEVVSTVRAKILALFADISKEQGADIPSITEELISLLKKEE SHKVLAQGVSALLKIGRLQPDNQGLxxxxxQVAIQRLKDTSHLVKCTSLE LIGDLLPVGATVETSPGSIMRLVGDYTHSDEGRVRSAAFRAMMTLHGRGL TLDPSVYSEACLALKDDYEIVRQEALRLVWVLGRTYPxxxxVLPSSDEEV RLVDDAFGKLCNMINDLSMNVRTLAAEKLGSMTLVSPKFLHQTLDKKLMS NMRKKRSAHERAWESITSGEWASGKNWSDDAPREVIDADSVSxMxxxxCG AFxxGLEDEFL-------------------EVRYASVESVCQLSLDNPQF AHMSLDFLVDMFNDEIEDVRIKAIDSLTRISRHIVLREDQLETILGALK- -------------------------------------------------- ----------------------------DFSMDVREGLHKMLASCRLSSK NCLQMCVESLLENLKKYPM------------------------------- -------------------------------------------------- --------------------------------------------DRRSTW HCLQKIGQSHPELTLPLVPELLAIHPFFDTPEPDVEDPA----------- ------------------------------YVCILILVFNAAQQSPTMLQ LFEEHTLKHYSYLRDTMPTLVPALK------------------------- -----LLGSSRPADPAPLSTGSAQYLSAILARIETAPSSCVRRELMEACR HDLSRLATIDRAIPGALQFSALYISSQLLMMDILSNKLWSNPSALASQQG NVVKNCISQLLSQCLKLQHLYVGLNTEDLSCVKQFKLKALALQLVYIVRG SNFSALALCEHFLETVEDTQRYLSEHEVQPEVFTSALFKELGLLEDTKPG PVARCLLPLLQVSTPAPLPHTNI--------------------------- -------------------------------------------------- ----------------------------------------EIRSSMAVIS EPTGDLETALKFTAGLVLGVHCDALLHNIQDISTLRIKVKYPDQQTHLLV PRPTDLRPLEPPDHRLLTTVLLSHHVWTEACIVEVSLALDVARAESGLAG RKVLSSGSVRSDDPWVLDLCRPVK-------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------VLVSPKP IKRGI >Tps xxAVLKKRALAxYSQTIQ-----------------------EEPPKPVKK LRLVKKLTLGNSAIVYIGLLEKSKSSNDALQVLVRIADCLKFE------- ---------YEVVSTVRAKILALFADISKEQGADIPSITEELISLLKKEE SHKVLAQGVSALLKIGRLQPDNQGLxxxxxQVAIQRLKDTSHLVKCTSLE LIGDLLPVGATVETSPGSIMRLVGDYTHSDEGRVRSAAFRAMMTLHGRGL TLDPSVYSEACLALKDDYEIVRQEALRLVWVLGRTYPxxxxVLPSSDEEV RLVDDAFGKLCNMINDLSMNVRTLAAEKLGSMTLVSPKFLHQTLDKKLMS NMRKKRSAHERAWESITSGEWASGKNWSDDAPREVIDAESVSxMxxxxCG AFxxGLEDEFL-------------------EVRYASVESVCQLSLDNPQF AHMSLDFLVDMFNDEIEEVRIKAIDSLTRISRHIVLREDQLETILGALK- -------------------------------------------------- ----------------------------DFSMDVREGLHKMLASCRLSSK NCLQMCVESLLENLKKYPM------------------------------- -------------------------------------------------- --------------------------------------------DRRSTW HCLQKIGQSHPELTLPLVPELLAIHPFFDTPEPDVEDPACILHSHTLWFN VCELELEQFYNIQH---------------LYVCILILVFNAAQQSPTMLQ LFEEHTLKHYSYLRDTMPTLVPALKSY---------------xxPxxLTR AVCxxLVGSSRPADPAPLSTGSAQYLSDILARIETAPSSCVRRELMEACR HDLSRLATIDRAIPGALQFSALYISSQLLMIDILSNKLWSNPSALASQQG NVVKNCISQLLSQCLKLQHLYVGLNTEDLSCVKQFKLKALALQLVYIVRG SNFSALALCEHFLETVEDTQRYLSEHEVQPEAFTSSLFKELGLLEDTKPG PVARCLLPLLQVSTPAPLPHTNIxxERKLKGVGESNSNAAVERSFSIIKE CLVENLHEDGLIAQYVTYDAVTAAGGLINMTISKKMIYAVRDAPGIRKEV LDKKKKIEIDLSQKRKTASEEIRKLEVKRRTVLQKAKEEEEIRSSMAVIS EPTGDLETALKFTAGLVLGVHCDALLHNIQDISTLRIKVKYPDQQTHLLV PRPTDLRPLEPPDHRLLTTILLSHHVWTEACIVEVSLALDVARAESGLAG RKVLSSGSMRSDDPWVLDLCRPVK-------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------VLVSPKP IKRGI >Tdi xxAVLKKRALAxYSQTIQ-----------------------EEPPKPVKK LRLVKKLTLGNSAIVYIGLLEKSKSSNDALQVLVRIADCLKFEEEDIPDV IKKxxxxFQYEVVSTVRAKILALFADISKEQGADIPSITEELISLLKKEE SHKVLAQGVSALLKIGRLQPDNQGLxxxxxQVAIQRLKDTSHLVKCTSLE LIGDLLPVGATVETSPGSIMRLVGDYTHSDEGRVRSAAFRAMMTLHGRGL TLDPSVYSEACLALKDDYEIVRQEALRLVWVLGRTYPxxxxVLPSSDEEV RLVDDAFGKLCNMINDLSMNVRTLAAEKLGSMTLVSPKFLHQTLDKKLMS NMRKKRSAHERAWESITSGEWASGKNWSDDAPREVIDAESVSxMxxxxCG AFxxGLEDEFL-------------------EVRYASVESVCQLSLDNPQF AHMSLDFLVDMFNDEIEEVRIKAIDSLTRISRHIVLREDQLETILGALK- -------------------------------------------------- ----------------------------DFSMDVREGLHKMLASCRLSSK NCLQMCVESLLENLKKYPM------------------------------- -------------------------------------------------- --------------------------------------------DRRSTW HCLQKIGQSHPELTLPLVPELLAIHPFFDTPEPDVEDPACILHSHTLWFN VCELELEQFYNIQH---------------LYVCILILVFNAAQQSPTMLQ LFEEHTLKHYSYLRDTMPTLVPALKSY---------------xxPxxLTR AVCxQLVGSSRPADPAPLSTGSAQYLSDILARIETAPSSCVRRELMEACR HDLSRLATIDRAIPGALQFSALYISSQLLMIDILSNKLWSNPSALASQQG NVVKNCISQLLSQCLKLQHLYVGLNTEDLSCVKQFKLKALALQLVYIVRG SNFSALALCEHFLETVEDTQRYLSEHEVQPEAFTSSLFKELGLLEDTKPG PVARCLLPLLQVSTPAPLPHTNIxxERKLKGVGESNSNAAVERSFSIIKE CLVENLHEDGLIAQYVTYDAVTAAGGLINMTISKKMIYAVRDAPGIRKEV LEKKKKIEIDLSQKRKTASEEIRKLEVKRRTVLQKAKEEEEIRSSMAVIS EPTGDLETALKFTAGLVLGVHCDALLHNIQDISTLRIKVKYPDQQTHLLV PRPTDLRPLEPPDHRLLTTILLSHHVWTEACIVEVSLALDVARAESGLAG RKVLSSGSMRSDDPWVLDLCRPVK-------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------VLVSPKP IKRGI >Tpa -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -----------------------------------------------MLQ LFEEHTLKHYSYLRDTMPTLVPALK------------------------- -----LLGSSRPADPAPLSTGSAQYLSAILARIETAPSSCVRRELMEACR HDLSRLATIDRAIPGALQFSALYISSQLLMMDILSNKLWSNPSALASQQG NVVKNCISQLLSQCLKLQHLYVGLNTEDLSCVKQFKLKALALQLVYIVRG SNFSALALCEHFLETVEDTQR----------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ----- >Tcm MxAVLKKRALAxYSQTIQ-----------------------EEPPKPVKK LRLVKKLTLGNSAIVYIGLLEKSKSSNDALQVLVRIADCLKFEEEDIPDV IKKxxxxFQYEVVSTVRAKILALFADISKEQGADIPSITEELISLLKKEE SHKVLAQGVSALLKIGRLQPDNQGLxxxxxxxxIQRLKDTSHLVKCTSLE LIGDLLPVGATVETSPGSIMRLVGDYTHSDEGRVRSAAFRAMMTLHGRGL TLDPSVYSEACLALKDDYEIVRQEALRLVWVLGRTYPxxxxVLPSSDEEV RLVDDAFGKLCNMINDLSMNVRTLAAEKLGSMTLVSPKFLHQTLDKKLMS NMRKKRSAHERAWESITSGEWASGKNWSDDAPREVIDAESVSxMxxxxCG AFxxGLEDEFLEDPLEx-------xxxxxxEVRYASVESVCQLSLDNPQF AHMSLDFLVDMFNDEIEEVRIKAIDSLTRISRHIVLREDQLETILGALK- -------------------------------------------------- ----------------------------DFSMDVREGLHKMLASCRLSSK NCLQMCVESLLENLKKYPM------------------------------- -------------------------------------------------- --------------------------------------------DRRSTW HCLQKIGQSHPELTLPLVPELLAIHPFFDTPEPDVEDPA----------- ------------------------------YVCILILVFNAAQQSPTMLQ LFEEHTLKHYSYLRDTMPTLVPALKV------------------------ -----LVGSSRPADPAPLSTGSAQYLSDILARIETAPSSCVRRELMEACR HDLSRLATIDRAIPGALQFSALYISSQLLMIDILSNKLWSNPSALASQQG NVVKNCISQLLSQCLKLQHLYVGLNTEDLSCVKQFKLKALALQLVYIVRG SNFSALALCEHFLETVEDTQRYLSEHEVQPEAFTSSLFKELGLLEDTKPG PVARCLLPLLQVSTPAPLPHTNI--------------------------- -------------------------------------------------- ----------------------------------------KIRSSMAVIS EPTGDLETALKFTAGLVLGVHCDALLHNIQDISTLRIKVKYPDQQTHLLV PRPTDLRPLEPPDHRLLTTILLSHHVWTEACIVEVSLALDVARAESGLAG RKVLSSGSMRSDDPWVLDLCRPVKxxxxxxxxxxVxxxxDGLKPENDATT PVQQSNSIFKDEPGIILENLMNAYDASVSTVNHCLGWEKQLxxxxxxxxE LELKVPEKSEWERMIPPTRNQTKPEEPMCLQHLEVHKxxSFEDILNAQQD EECRKIQKLWKTLRGGQSTNMKDVNFWNTHPVKDRQFLRRTDKE------ ----- >Tms MxAVLKKRALAxYSQTIQ-----------------------EEPPKPVKK LRLVKKLNLGNSAIVYIGLLEKSKSSNDALQVLVRIADCLKFEEEDIPDV IKKxxxxFQYEVVSTVRAKILALFADISKEQGADIPSITEELISLLKKEE SHKVLAQGVSALLKIGRLQPDNQGLxxxxxxxxIQRLKDTSHLVKCTSLE LIGDLLPVGATVETSPGSIMRLVGDYTHSDEGRVRSAAFRAMMTLHDRGL TLDPSVYSEACLALKDDYEIVRQEALRLVWVLGRTYPxxxxVLPSSDEEV RLVDDAFGKLCNMINDLSMNVRTLAAEKLGSMTLVSPKFLHQTLDKKLMS NMRKKRSAHERAWESITSGEWASGKNWSDDAPREVIDAESVSxxxxxxCG AFxxGLEDEFL-------------------EVRYASVESVCQLSLDNPQF AHMSLDFLVDMFNDEIEEVRIKAIDSLTRISRHIVLREDQLETILGALKx xxxx--------------------xxxxxxxxxxxxxxxxxxxxxxxxxx xxxxxxxxxxxxxxxxxxxxxxxxxxxxx--------------------- ------VESLLEKLKKYPM------------------------------- -------------------------------------------------- --------------------------------------------DRRSTW HCLQKIGQSHPELTLPLVPELLAIHPFFDTPEPDVEDPA----------- ------------------------------YVCILILVFNAAQQSPTMLQ LFEEHTLKHYSYLRDTMPTLVPALK------------------------- -----LVGSSRPADPASLSTGSAQYLSAILARIETAPSSCVRRELMEACR HDLSRLATIDRAIPGALQFSALYISSQLLMIDILSNKLWSNPSALASQQG NVVKNCISQLLSQCLKLQHLYVGLNTEDLSCVKQFKLKALALQLVYIVRG SNFSALALCEHFLETVEDTQRYLSEHEVQPEAFTSSLFKELGLLEDTKPG PVARCLLPLLQVSTPAPLPHTNI--------------------------- -------------------------------------------------- ----------------------------------------EIRSSMAVIS EPTGDLETALKFTAGLVLGVHCDALLHNIQDISTLRIKVKYPDQQTHLLV PRPTDLRPLEPLNHRLLTTILLSHHVWTEACIVEVSLALDVARAESGLAG RKVLSSGSMRSDDPWVLDLCRPVK-------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------VLVSPKP IKRGI >Tce -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------MRLVGDYTHSDEGRVRSAAFRAMMTLHDRGL TLDPSVYSEACLALKDDYEIVRQEALRLVWVLGRTYPxxxxVLPSSDEEV RLVDDAFGKLCNMINDLSMNVRTLAAEKLGSMTLVSPKFLHQTLDKKLMS NMRKKRSAHERAWESITSGEWASGKNWSDDAPREVIDAESVSxxxxxxCG AFxxGLEDEFL-------------------EVRYASVESVCQLSLDNPQF AHMSLDFLVDMFNDEIEEVRIKAIDSLTRISRHIVLREDQLETILGALKx xxxxxxxxxxxx--------xxxxxxxxxxxxxxxxxxxxxxxxxxxxxx xxxxxxxxxxxxxxxxxxxxxxxxxxxxx--------------------- ------VESLLEKLKKYPM------------------------------- -------------------------------------------------- --------------------------------------------DRRSTW HCLQKIGQSHPELTLPLVPELLAIHPFFDTPEPDVEDPA----------- ------------------------------YVCILILVFNAAQQSPTMLQ LFEEHTLKHYSYLRDTMPTLVPALK------------------------- -----LVGSSRPADPASLSTGSAQYLSAILARIETAPSSCVRRELMEACR HDLSRLATIDRAIPGALQFSALYISSQLLMIDILSNKLWSNPSALASQQG NVVKNCISQLLSQCLKLQHLYVGLNTEDLSCVKQFKLKALALQLVYIVRG SNFSALALCEHFLETVEDTQRYLSEHEVQPEAFTSSLFKELGLLEDTKPG PVARCLLPLLQVSTPAPLPHTNI--------------------------- -------------------------------------------------- ----------------------------------------EIRSSMAVIS EPTGDLETALKFTAGLVLGVHCDALLHNIQDISTLRIKVKYPDQQTHLLV PRPTDLRPLEPLNHRLLTTILLSHHVWTEACIVEVSLALDVARAESGLAG RKVLSSGSMRSDDPWVLDLCRPVK-------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------VLVSPKP IKRGI >Tsi x----------------xxxxxxxxxxxxxxxxxxxxxxxxEEPPKPVKK LRLVKKLTLGNSAIVYIGLLEKSKSSNDALQVLVRIADCLKFEEEDIPDV IKKxxxxFQYEVVSTVRAKILALFADISKEQGADIPSITEELISLLKKEE SHKVLAQGVSALLKIGRLQPDNQGLxxxxxQVAIQRLKDTSHLVKCTSLE LIGDLLPVGATVETSPGSIMRLVGDYTHSDEGRVRSAAFRAMMTLHGRGL TLDPSVYSEACLALKDDYEIVRQEALRLVWVLGRTYPxxxxVLPSSDEEV RLVDDAFGKLCNMINDLSMNVRTLAAEKLGSMTLVSPKFLHQTLDKKLMS NMRKKRSAHERAWESITSGEWASGKNWSDDAPREVIDAESVSxMxxxxCG AFxxGLEDEFL-------------------EVRYASVESVCQLSLDNPQF AHMSLDFLVDMFNDEIEEVRIKAIDSLTRISRHIVLREDQLETILGALK- -----------xxxxxxxxxxxx--------------------------- ----------------------------DFSMDVREGLHKMLASCRLSSK NCLQMCVESLLENLKKYPM------------------------------- -------------------------------------------------- --------------------------------------------DRRSTW HCLQKIGQSHPELTLPLVPELLAIHPFFDTPEPDVEDPACILHSHTLWFN VCELELEQFYNIQHxxLNSLFxxxxxxxxLDVCILILVFNAAQQSPTMLQ LFEEHTLKHYSYLRDTMPTLVPALKSY---------------xxPxxLTR AVCxQLVGSSRPADPAPLSTGSAQYLSDILARIETAPSSCVRRELMEACR HDLSRLATIDRAIPGALQFSALYISSQLLMIDILSNKLWSNPSALASQQG NVVKNCISQLLSQCLKLQHLYVGLNTEDLSCVKQFKLKALALQLVYIVRG SNFSALALCEHFLETVEDTQRYLSEHEVQPEAFTSSLFKELGLLEDTKPG PVARCLLPLLQVSTPAPLPHTNIxxGRKLKGVRESNSNAAVERSFSMNKE CLVENLHEDGLIAQx----------------------------------- -----------------------------------------IRSSMAVIS EPTGDLETALKFTAGLVLGVHCDALLHNIQDISTLRIKVKYPDQQTHLLV PRPTDLRPLEPPDHRLLTTILLSHHVWTEACIVEVSLALDVARAESGLAG RKVLSSGSMRSDDPWVLDLCRPVK-------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------VLVSPKP IKRGI