>Tge x------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -----------------xxxxxxxx---------------xxxxxxxxxx xxxxxxxxxxxxxxx----------------------------------- xxxxxLE--S--QGQGRDKDHHLNGKQRHQLKHRELFLSRQMETLPATHI RGKCSVTLLNETESLLSYLNKDDTFFYCLVFDPTHKTLLADKGEIRVGSR YQADATALLKEDESDNRNLEELETLVWTPSHNLTDRQIDQFLVISRSVGT FARALDCSSSVKQPSLHMSAAAASRDITLNNQLGTKPDLSGQQSLPHTHM NLVVTNELCSVSWCRVEHTASECIPxFHAMDTLHKHDYNMAEAISSLVPS TGPVLCRDEMEEWSASEANLFEEALDKYGKDFNDIRQDF----------- -------------------------------LPWKTLKNIIEYYYMWKTT DRYVQQKRVKAVEAESKLKQVYIPNYNKANSSVINNNKGVVNGSSNGEAL IGGKACESCNATVSSQWYAWGPTHMQCKLCHNCWLYWKKYGGLKVPSRIG ENEIDLKKKSGSVSDE-----------xxxxxxxxxxxxxxxL---xxxx xxxxxxxxxxxxxxxxxxxxxxxxxxVxxxxxxxxxKGALDDVVYLVSVA FLFFFPPLLPLPLxxxxxxxxxxxxxxxxxxxxxx--------------- ------EFKLKAQLARHYATAHGLAIRSGSPRPIMKTRTAFYLCTTPLTR ISRRLCRHLIQPRHAARAPFWPINIPSVKQECTYYITY------------ ----SQLHMAGKSVLELRELLRYRKKERGSVTLIANRLGQPNLITPEWLI LTPKDMMPLPEHVSFPKPPKAPDGTLLYxRVxNKPEAEKAALNNIxPxxL xxxxYEExxxxx----------xxxxxxVGTSMxxYRLxxVF-------- ----------------------VTRVGxxxxGECVPSTLVAVEQKDVPAT LVAVEQKDVPATLVAVERKDVPATLVAVERKDVPATLVAVERKDVPATLV AVERKDVPATLVAVERKDVPATLVAVERKDVPATLVAVERKDVPATLVAV ERKDVPATLVAVERKDVPATLVALEHEEVPAILENMDCGAVQAVERVGGA xxxxxxxxxxxRLNSEAQQVDxxxLVVPQPGPPAKRAHKDPGPMRAPDSF xxxxxxxxxNHxxxxxxxATMTRSGSGRKQVISWMDAPxxxxFRSxxxxx xxRRQLTGTELRRAARKPWRKLNTKCMVDNLLVILD-------------- -------------------------------------------------- -------------------------------------------------- - >Tpa x------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -----------------xxxxxxxx---------------xxxxxxxxxx xxxxxxxxxxxxxxxxxxxxxxxxxxxxx--------------------x ALEEELE--S--QGQGRDKDHHLNGKQRHQLKHRELFLSRQMETLPATHI RGKCSVTLLNETESLLSYLNKDDTFFYCLVFDPTHKTLLADKGEIRVGSR YQADATALLKEDESDNRNLEELETLVWTPSHNLTDRQIDQFLVISRSVGT FARALDCSSSVKQPSLHMSAAAASRDITL--------------------- --------------------------FHAMDTLHKHDYNMAEAISSLVPS TGPVLCRDEMEEWSASEANLFEEALDKYGKDFNDIRQDF----------- -------------------------------LPWKTLKNIIEYYYMWKTT DRYVQQKRVKAVEAESKLKQV-----NKANSSVINNNKGVVNGSSNGEAL IGGKACESCNATVSSQWYAWGPTHMQCKLCHNCWLYWKKYGGLK------ -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ------EFKLKAQLARHYATAHGLAIRSGSPRPIMKTRTAFYLCTTPLTR ISRRLCRHLIQPRHAARAPFWPINIPSVKQECTYYIT------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- - >Tdi xxxxxxxxxxx--------------------------------------- -------------------------------------------------- ------------------------------------------------xx ---------------x---------x------------------------ -------------------------------------------------- ----------------xx-------------------------------- -------------------------------------------------- xxxxxLE--S--QGQGRDKDHHLNGKQRHQLKHRELFLSRQMETLPATHI RGKCSVTLLNETESLLSYLNKDDTFFYCLVFDPTHKTLLADKGEIRVGSR YQADATALLKEDESDNRNLEELETLVWTPSHNLTDRQIDQFLVISRSVGT FARALDCSSSVKQPSLHMSAAAASRDITLCNQLGTKLDLSGQQSILHTHI NLVVTNELCSVSWCRVEHTASECIPxFHAMDTLHKHDYNMAEAISSLVPS TGPVLCRDEMEEWSASEANLFEEALDKYGKDFNDIRQDF----------- -------------------------------LPWKTLKNIIEYYYMWKTT DRYVQQKRVKAVEAESKLKQVYIPNYNKANSSVINNNKGVVNGSSNGEAL IGGKACESCNATVSSQWYAWGPTHMQCKLCHNCWLYWKKYGGLKVPSRIG ENEIDLKKKSGSVSDE---------------------------------- -------------------------------------------------- ----------------------------------xxxxxxxxxxxxxxxx xxxxxKEFKLKAQLARHYATAHGLAIRSGSPRPIMKTRTAFYLCTTPLTR ISRRLCRHLIQPRHAARAPFWPINIPSVKQECTYYINY------------ ----SQLHMAGKSVLELRELLRYRKKERGSVTHIANRLGQPNLITPEWLI LTPKDMMPLPEHVSFPKPPKAPDGTLLYxRVxNKPEAEKAALNNIxPxxL xxxxYEExxxxx----------x--------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ------------------------xVVPQPGPPAKRAHKDPGPMRAPDSF xxxxxxxxxNHxxxxxxxATMTRSGSGRKQVISWMDAPxxxxFRSxxxxx xxRRQLTGTELRRAARKPWRKLNAKCMVDNLLVILD-------------- -------------------------------------------------- -------------------------------------------------- - >Tsi x------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -----------------x------xxxxxxxxxxxxxxxxxxxxxxxxxx xxxxxxxxxxxxxxx----------------------------------- xxxxxLE--xxxQGQGRDKDHHLNGKQRHQLKHRELFLSRQMETLPATHI RGKCSVTLLNETESLLSYLNKDDTFFYCLVFDPTHKTLLADKGEIRVGSR YQADATALLKEDESDNRNLEELETLVWTPSHNLTDRQIDQFLVISRSVGT FARALDCSSSVKQPSLHMSAAAASRDITL--------------------- --------------------------FHAMDTLHKHDYNMAEAISSLVPS TGPVLCRDEMEEWSASEANLFEEALDKYGKDFNDIRQDF----------- -------------------------------LPWKTLKNIIEYYYMWKTT DRYVQQKRVKAVEAESKLKQVYIPNYNKANSSVINNNKGVVNGSSNGEAL IGGKACESCNATVSSQWYAWGPTHMQCKLCHNCWLYWKKYGGLKVPSRIG E-----------------------------------------xxxxxx-- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- - >Tms M------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------xxxxxxxxxYVxxxQSxTSPYxxRx xxxxxKTPxxxxxxKVMxxxxxxxxxxxxxxxxxxxxxxSSDESPVAMKL KKMWxxxxxxxxxxxxxx-------------------------------- -------------------------------------------------- ALEEELE--S--QGQGRDKDHHLNGKQRHQLKHRELFLSRQMETLPATHI RGKCSVTLLNETESLLSYLNKDDTFFYCLVFDPTHKTLLADKGEIRVGSR YQADATALLKEDESDNRNLEELETLVWTPSHNLTDRQIDQFLVISRSVGT FARALDCSSSVKQPSLHMSAAAASRDITL--------------------- --------------------------FHAMDTLHKHDYNMAEAISSLVPS TGPVLCRDEMEEWSASEANLFEEALDKYGKDFNDIRQDF----------- -------------------------------LPWKTLKNIIEYYYMWKTT DRYVQQKRVKAVEAESKLKQVYIPNYNKANSSVINNNKGVVNGSSNGEAL IGGKACESCNATVSSQWYAWGPTHMQCKLCHNCWLYWKKYGGLKVPSRIG ENEIDLKKKSGSVSDE---------------------------------- -------------------------------------------------- ----------------------------------ERxxxxxxxxxxxRCS LVNCGKEFKLKAQLARHYATAHGLAIRSGSPRPIMKTRTAFYLCTTPLTR ISRRLCRHLIQPRHAARAPFWPINIPSVKQEC------------------ -----QLHMAGKSVLELRELLRYRKKERGSVTHIANRLGQPNLITPEWLI LTPKDMMPLPEHVSFPKPPKAPDGTLLYxRVxNKPEAEKAALNNIxPxxL xxxxYEExxxxxxxNSDLDWDEx--------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ------------------------LVVPQPGPPAKRAHKDPGPMRAPDSF xxxxxxxxxNHxxxxxxxATMTRSGSGRKQVISWMDAPxxxxFRSxxxxx ------------------------------------xxxxxxxxxxxxxx xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx------------------- ---------------------------------------------xxxxx x >Tce M------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------xxxxxxxxxxxxxxxxxxxxYxxRx xxxxxxxPxxxxxxKVMxxxxxxxxxxxxxxxxxxxxxxSSDESPVAMKL KKMWxxxxxxxxxxxxxx-------------------------------- -------------------------------------------------- ALEEELE--S--QGQGRDKDHHLNGKQRHQLKHRELFLSRQMETLPATHI RGKCSVTLLNETESLLSYLNKDDTFFYCLVFDPTHKTLLADKGEIRVGSR YQADATALLKEDESDNRNLEELETLVWTPSHNLTDRQIDQFLVISRSVGT FARALDCSSSVKQPSLHMSAAAASRDITL--------------------- --------------------------FHAMDTLHKHDYNMAEAISSLVPS TGPVLCRDEMEEWSASEANLFEEALDKYGKDFNDIRQDF----------- -------------------------------LPWKTLKNIIEYYYMWKTT DRYVQQKRVKAVEAESKLKQVYIPNYNKANSSVINNNKGVVNGSSNGEAL IGGKACESCNATVSSQWYAWGPTHMQCKLCHNCWLYWKKYGGLKVPSRIG ENEIDLKKKSGSVSDE---------------------------------- -------------------------------------------------- ----------------------------------xxxxxxxxxxxxxxxS LVNCGKEFKLKAQLARHYATAHGLAIRSGSPRPIMKTRTAFYLCTTPLTR ISRRLCRHLIQPRHAARAPFWPINIPSVKQEC------------------ -----QLHMAGKSVLELRELLRYRKKERGSVTHIANRLGQPNLITPEWLI LTPKDMMPLPEHVSFPKPPKAPDGTLLYxRVxNKPEAEKxxxxxxxPxxL xxxxYEExxxxxxxNSDLDWDEx--------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ------------------------LVVPQPGPPAKRAHKDPGPMRAPDSF xxxxxxxxxNxxxxxxxxATMTRSGSGRKQVISWMDAPxxxxFRSxxxxx xxRRQLTGTELRRAARKPWRKLNAKCMVDNLLVILD-------------- -------------------------------------------------- -------------------------------------------------- - >Tps x------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ---------------xxxxxxxxxxx------------------------ -------------------------------------------------- -----------------x-------------------------------- -------------------------------------------------- ALEEELE--S--QGQGRDKDHHLNGKQRHQLKHRELFLSRQMETLPATHI RGKCSVTLLNETESLLSYLNKDDTFFYCLVFDPTHKTLLADKGEIRVGSR YQADATALLKEDESDNRNLEELETLVWTPSHNLTDRQIDQFLVISRSVGT FARALDCSSSVKQPSLHMSAAAASRDITL--------------------- --------------------------FHAMDTLHKHDYNMAEAISSLVPS TGPVLCRDEMEEWSASEANLFEEALDKYGKDFNDIRQDFVELKQRKVRRL KASLRMSRGVGHIGTTLKTEIKEKAKGEQPQLPWKTLKNIIEYYYMWKTT DRYVQQKRVKAVEAESKLKQVYIPNYNKANSSVINNNKGVVNGSSNGEAL IGGKA-----STVSSQWYAWGPTHMQCKLCHNCWLYWKKYGGLKVPSRIG ENEIDLKKKSGSVSDExxxxxxxxxxxx---------------------- -------------------------------------------------- -------------------------------------------------- -----KEFKLKAQLARHYATAHGLAIRSGSPRPIMKTRTAFYLCTTPLTR ISRRLCRHLIQPRHAARAPFWPINIPSVKQEC------------------ -----QLHMAGKSVLELRELLRYRKKERGSVTHIANRLGQPNLITPEWLI LTPKDMMPLPEHVSFPKPPKAPDGTLLYxRVxNKPEAEKAALNNIxPxxL xxxxYEExxxxx----------x--------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ------------------------LVVPQPGPPAKRAHKDPGPMRAPDSF xxxxxxxxxNHxxxxxxxATMTRSGSGRKQVISWMDAPxxxxFRSxxxxx xxRRQLTGTELRRAARKPWRKLNAKCMVDNLLVILD-------------- -------------------------------------------------- -------------------------------------------------- - >Tbi x------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ----------------------------xxxxxxxxxxxxxxxxxxxxxx ALExxLE--S--QGQGRDKDHHLNGKQRHQLKHRELFLSRQMETLPATHI RGKCSVTLLNETESLLSYLNKDDTFFYCLVFDPTHKTLLADKGEIRVGSR YQADATALLKEDESDNRNLEELETLVWTPSHNLTDRQIDQFLVISRSVGT FARALDCSSSVKQPSLHMSAAAASRDITL--------------------- --------------------------FHAMDTLHKHDYNMAEAISSLVPS TGPVLCRDEMEEWSASEANLFEEALDKYGKDFNDIRQDF----------- -------------------------------LPWKTLKNIIEYYYMWKTT DRYVQQKRVKAVEAESKLKQV-----NKANSSVINNNKGVVNGSSNGEAL IGGKACESCNATVSSQWYAWGPTHMQCKLCHNCWLYWKKYGGL------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -----xEFKLKAQxxRHYATAHGLAIRSGSPRPIMKTRTxFYLCxxxxTR ISRRLCRHLIQPRHAARAPFWPINIPSVKQECTYYINYSRIKIKMITIKM QLTISQLHMAGKSVLELRELLRYRKKERGSVTLIANRLGQPNLITPEWLI LTPKDMMPLPEHVSFPKPPKAP---------------------------- ----------------------------------------xxxxxxxxxx xxxxxxxxxxxxxxxxxxxxxxx--------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- - >Tcm M------------------------------------xxxxP-------- -------------------------------------------------- ----------------------TxxVLxxxxxxxxxxxGxxxERSCxQxx xxxxxPPxxxxxxxxx-----------------xxxxxxxxxTSxxxxxx xxxxxxxxxxxxxxKVMxxxxxxxxxxxxxxxxxxx-------------- -------------------------------------------------- ------------------------------------------------xx ALEEELExxS--QGQGRDKDHHLNGKQRHQLKHRELFLSRQMETLPATHI RGKCSVTLLNETESLLSYLNKDDTFFYCLVFDPTHKTLLADKGEIRVGSR YQADATALLKEDESDNRNLEELETLVWTPSHNLTDRQIDQFLVISRSVGT FARALDCSSSVKQPSLHMSAAAASRDITL--------------------- --------------------------FHAMDTLHKHDYNMAEAISSLVPS TGPVLCRDEMEEWSASEANLFEEALDKYGKDFNDIRQDF----------- -------------------------------LPWKTLKNIIEYYYMWKTT DRYVQQKRVKAVEAESKLKQVYIPNYNKANSSVINNNKGVVNGSSNGEAL IGGKACESCNATVSSQWYAWGPTHMQCKLCHNCWLYWKKYGGLKVPSRIG -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ------------------------------xxxxxxxxxxxxxxxxxxxx xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx---- - >Tte x--------xxxxxxxxCCPxxxxxGPEYNSCNGDVTIxPHPxxxPRSxx xxxxxxxxKPAARxxPxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx xxxxxxxxxFxxxxxxxxxxxxx--------------------------- -------------------------------------------------- ------xxxxxxxxKVMxxxxxxxxxxxxxxxxxxx-------------- -------------------------------------------------- ------------------------------------------------xx ALEEELE--S--QGQGRDKDHHLNGKQRHQLKHRELFLSRQMETLPATHI RGKCSVTLLNETESLLSYLNKDDTFFYCLVFDPTHKTLLADKGEIRVGSR YQADATALLKEDELDNRNLEELETLVWTPSHNLTDRQIDQFLVISRSVGT FARALDCSSSVKQPSLHMSAAAASRDITL--------------------- --------------------------FHAMDTLHKHDYNMAEAISSLVPS TGPVLCRDEMEEWSASEANLFEEALDKYGKDFNDIRQDF----------- -------------------------------LPWKTLKNIIEYYYMWKTT DRYVQQKRVKAVEAESKLKQVYIPNYNKANSSVINNNKGVVNGSSNGEAL IGGKACESCNATVSSQWYAWGPTHMQCKLCHNCWLYWKKYGGLKVPSRIG -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ------------------------------xxxxxxxxxxxxxxxxxxxx xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx---- -