>Tge -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ---xPTTQGAVQTPSRAPSRLQHGVEDSEDGPQDTSQDAPNGKSLLQVQH TGEDPATTPRSEQSGNQESQSSHRNNSGHHNHASNGLAASSRPGSALAIA NHHHRKSDTTEEDEEExxEDEDEEESRRARPVVATAVVVASSKEGGFWRA TASRPTSPGGGAAMADNASEASSTMLPPARPKSRAEHKAANSKYSNLSYW RARRVTFYRNGDPFFPGVEFRFKPGRDISNLEALLDKLSLRMDLPHGARY VFTMDGERRMRLEELEDGSSYVVSSYKTFKAASYGKKNGVWYGVPASTSS QGWSKPPLSRKASIVETEAPPPGGGNSTKPSSGRVIRIINNLDHSVQCRV LLNLRTSQPFEEVLEDLGQVLKMNGAKRMYTVNGQEVRSFSQLRNEFADV DTFYLSSNYGLSSPVRRSRSRAASHGPLVEDLTIRDVSRQRRARSKSRGR VLYADTDLVRGNDYTLVEVMKEEPVRVTIRGLRRTFYPPLHHPPYDNAPP EKRLQLNWLRVQRHRLATELVGPADRGATVLRGGGGRAVRQRRGVPETLH xxxxxxxx------------------------------------------ -------------------------------------------------- -------------------------------------------------- ---RAGRNRKTQAHIRIWSTETLLTLYVFGMGEFDLGVSAVAFSQLNGGS YVLAVDGGRERILSVWQWQWGHLLGKVATLHDDLTGASFHPLDDNLLITH GKGHLTFWTRRKDGFFERTDIIKPPSRTHVTSIQFEQDGDVVTADGDGFI TVYSVDSDGAYFVRMEFEAHNKGISSLVMLSEGTLLSGGEKDRKIVAWDS LQNYKKITETKLPESAGGVRSIYPQRPGRNDGNIYVGTTRNNIMEGSLQR RFNQVVFGHGRQLWGLAVHPDDELFATAGHDKNIALWNRQKLIWST---Q I------------------------------------------AYECVSL TFHPFGVALAAGSTEGHLVVLNAESGAPAATIRVCGSPLSCIGYNPAGDM IAIGSQNGSVYLFRVSRDGFSYKKSNKIRGTQALNHLDWSTDGNYLQTVT ADYDLAFWDVKSMTAEKSPISMKDVKWYTLNCTVGFLVAGIWNNRFYPMT SVITTVNRSMAHDMLICGDADGYIRLFKYPCLSAKAEYNEDKVYSLQVAC ARFLFNDKYVVTVGGTDAALMLWDVVED >Tbi -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ---xPTTQGAVQTPSRAPSRLQHGVEDSEDGPQDTSQDAPNGKSLLQVQH TGEDPATTPRSEQSGNQASQSSHRNNSGHHNHASNGLAASSRPGSALAIA NHHHRKSDTTEEDEEE--EDEDEEESRRARPAVATAVVVASSKEGGFWRA TASRPTSPGGGAAMADNASEASSTMLPPTRPKSRAEHKAANSKYSNLSYW RARRVTFYRNGDPFFPGVEFRFKPGRDISNLEALLDKLSLRMDLPHGARY VFTMDGERRMRLEELEDGSSYVVSSYKTFKAASYGKKNGVWYGVPASTSS QGWSKPPLSRKASIVETEAPPPGGGNSTKPSSGRVIRIINNLDHSVQCRV LLNLRTSQPFEEVLEDLGQVLKMNGAKRMYTVNGQEVRSFSQLRNEFADV DTFYLSSNYGLSSPVRRSRSRAASHGPLVEDLTIRDVSRQRRARSKSRGR VLYADTDLVRGNDYTLVEVMKEEPVRVTIRGLRRTFYPPLHHPxxxNxxx ExxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxGGRAVRQRRGVPETLH xxxxxxxx------------------------------------------ -------------------------------------------------- -------------------------------------------------- ---RAGRNRKTQAHIRIWSTETLLTLYVFGMGEFDLGVSAVAFSQLNGGS YVLAVDGGRERILSVWQWQWGHLLGKVATLHDDLTGASFHPLDDNLLITH GKGHLTFWTRRKDGFFERTDIIKPPSRTHVTSIQFEQDGDVVTADGDGFI TVYSVDSDGAYFVRMEFEAHNKGISSLVMLSEGTLLSGGEKDRKIVAWDS LQNYKKITETKLPESAGGVRSIYPQRPGRNDGNIYVGTTRNNIMEGSLQR RFNQVVFGHGRQLWGLAVHPDDELFATAGHDKNIALWNRQKLIWST---Q I------------------------------------------AYECVSL TFHPFGVALAAGSTEGHLVVLNAESGAPAATIRVCGSPLSCIGYNPAGDM IAIGSQNGSVYLFRVSRDGFSYKKSNKIRGTQALNHLDWSTDGNYLQTVT ADYDLAFWDVKSMTAEKSPISMKDVKWYTLNCTVGFLVAGIWNNRFYPMT SVITTVNRSMAHDMLICGDADGYIRLFKYPCLSAKAEYNEDKVYSLQVAC ARFLFNDKYVVTVGGTDAALMLWDVVED >Tte -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ---xPTTQGAVQTPSRAPSRLQHGVEDSEDGPQDTSQDAPNGKSLLQVQH TGEDPATTPRSEQSGNQASQSSHRNNSGHHNHASNGLAASSRPGSALAIA NHHHRKSDTTEEDEEE--EDEDEEESRRARPAVATAVVVASSKEGGFWRA TASRPTSPGGGAAMADNASEASSTMLPPTRPKSRAEHKAANSKYSNLSYW RARRVTFYRNGDPFFPGVEFRFKPGRDISNLEALLDKLSLRMDLPHGARY VFTMDGERRMRLEELEDGSSYVVSSYKTFKAASYGKKNGVWYGVPASTSS QGWSKPPLSRKASIVETEAPPPGGGNSTKPSSGRVIRIINNLDHSVQCRV LLNLRTSQPFEEVLEDLGQVLKMNGAKRMYTVNGQEVRSFSQLRNEFADV DTFYLSSNYGLSSPVRRSRSRAASHGPLVEDLTIRDVSRQRRARSKSRGR VLYADTDLVRGNDYTLVEVMKEEPVRVTIRGLRRTFYPPLHHPPYDNAPP EKRLQLNWLRVQRHRLATELVGPADRGATVLRGGGGRAVRQRRGVPETLH xxxxxxxx------------------------------------------ -------------------------------------------------- -------------------------------------------------- ---RAGRNRKTQAHIRIWSTETLLTLYVFGMGEFDLGVSAVAFSQLNGGS YVLAVDGGRERILSVWQWQWGHLLGKVATLHDDLTGASFHPLDDNLLITH GKGHLTFWTRRKDGFFERTDIIKPPSRTHVTSIQFEQDGDVVTADGDGFI TVYSVDSDGAYFVRMEFEAHNKGISSLVMLSEGTLLSGGEKDRKIVAWDS LQNYKKITETKLPESAGGVRSIYPQRPGRNDGNIYVGTTRNNIMEGSLQR RFNQVVFGHGRQLWGLAVHPDDELFATAGHDKNIALWNRQKLIWST---Q I------------------------------------------AYECVSL TFHPFGVALAAGSTEGHLVVLNAESGAPAATIRVCGSPLSCIGYNPAGDM IAIGSQNGSVYLFRVSRDGFSYKKSNKIRGTQALNHLDWSTDGNYLQTVT ADYDLAFWDVKSMTAEKSPISMKDVKWYTLNCTVGFLVAGIWNNRFYPMT SVITTVNRSMAHDMLICGDADGYIRLFKYPCLSAKAEYNEDKVYSLQVAC ARFLFNDKYVVTVGGTDAALMLWDVVED >Tcm -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- --------GAVQTPSRAPSRLQHGADDSEDGPQDTSQDAPNGKSLLQVQH AGEDPATTPRSEQSGNQAGQSSQRNNSGHHNHASNGLAASSRPGSALAVA NHHHRKSDTTEEDEEE--EDEDEEERRRARPAVATAVVVASSKEGGFWRA TASRPTSPGGGAAMADNASEASSTMLPPARPKSRAEHKAANSKYSNLSYW RARRVTFYRNGDPFFPGVEFRFKPGRDISNLEALLDKLSLRMDLPHGARY VFTMDGERRMRLEELEDGSSYVVSSYKTFKAASYGKKNGVWYGVPASTSS QGWSKPPLSRKASIVETEAPPPGGGNSTKPSSGRVIRIINNLDHSVQCRV LLNLRTSQPFEEVLEDLGQVLKMNGAKRMYTVNGQEVRSFSQLRNEFADV DTFYLSSNYGLSSPVRRSRSRAASHGPLVEDLTIRDVSRQRRARSKSRGR VLYADTDLVRGNDYTLVEVMKEEPVRVTIRGLRRTFYPPLHHPPYDNTPP EKRLQLNWLRVQRHRLATELVGPADRGATVLRGGGGGALRQRRGVPETLH xxxxxxxx------------------------------------------ -------------------------------------------------- -------------------------------------------------- ---RAGRNRKTQAHIRIWSTETLLTLYVFGMGEFDLGVSAVAFSQLNGGS YVLAVDGGRERILSVWQWQWGHLLGKVATLHDDLTGASFHPLDDNLLITH GKGHLTFWTRRKDGFFERTDIIKPPSRTHVTSIQFEQDGDVVTADGDGFI TIYSVDSDGAYFVRMEFEAHNKGISSLVMLSEGSLLSGGEKDRKIVAWDS LQNYKKITETKLPESAGGVRSIYPQRPGRNDGNIYVGTTRNNIMEGSLQR RFNQVVFGHGRQLWGLAVHPDDELFATAGHDKNIALWNRQKLIWST---Q I------------------------------------------AYECVSL SFHPFGVALAAGSTEGHLVVLNAESGAPAATIRVCGSPLSCIGYNPAGDM IAIGSQNGSVYLFRVSRDGFSYKKSNKIRGTQALNHMDWSTDGNYLQTVT GDYDLAFYN-----------------------------SGIWNNRFYPTT SVITTVNRSMAHDMLICGDADGYIRLFKYPCLSAKAEYNEDKVYSLQVAC ARFLFNDKYVVTVGGTDAALMLWDVVED >Tdi -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- --------GAVQTPSRAPSRLQHGADDSEDGPQDTSQDAPNGKSLLQVQH AGEDPATTPRSEQSGNQAGQSSQRNNSGHHNHASNGLAASSRPGSALAVA NHHHRKSDTTEEDEEE--EDEDEEERRRARPAVATAVVVASSKEGGFWRA TASRPTSPGGGAAMADNASEASSTMLPPARPKSRAEHKAANSKYSNLSYW RARRVTFYRNGDPFFPGVEFRFKPGRDISNLEALLDKLSLRMDLPHGARY VFTMDGERRMRLEELEDGSSYVVSSYKTFKAASYGKKNGVWYGVPASTSS QGWSKPPLSRKASIVETEAPPPGGGNSTKPSSGRVIRIINNLDHSVQCRV LLNLRTSQPFEEVLEDLGQVLKMNGAKRMYTVNGQEVRSFSQLRNEFADV DTFYLSSNYGLSSPVRRSRSRAASHGPLVEDLTIRDVSRQRRARSKSRGR VLYADTDLVRGNDYTLVEVMKEEPVRVTIRGLRRTFYPPLHHPPYDNTPP EKRLQLNWLRVQRHRLATELVGPADRGATVLRGGGGGALRQRRGVPETLH xxxxxxxx------------------------------------------ -------------------------------------------------- -------------------------------------------------- ---RAGRNRKTQAHIRIWSTETLLTLYVFGMGEFDLGVSAVAFSQLNGGS YVLAVDGGSERILSVWQWQWGHLLGKVATLHDDLTGASFHPLDDNLLITH GKGHLTFWTRRKDGFFERTDIIKP-------------------------- ------------------AHNKGISSLVMLSEGTLLSGGEKDRKIVAWDS LQNYKKITETKLPESAGGVRSIYPQRPGRNDGNIYVGTTRNNIMEGSLQR RFNQVVFGHGRQLWGLAVHPDDELFATAGHDKNIALWNRQKLIWST---Q I------------------------------------------AYECVSL SFHPFGVALAAGSTEGHLVVLNAESGAPAATIRVCGSPLSCIGYNPAGDM IAIGSQNGSVYLFRVSRDGFSYKKSNKIRGTQALNHMDWSTDGNYLQTVT GDYDLAFC------------------------------------------ -------------------------------------------------- ---------------------------x >Tps -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ---------------------------------------xxxxxxxxxxx xxxRAGRNRKTQAHIRIWSTETLLTLYVFGMGEFDLGVSAVAFSQLNGGS YVLAVDGGRERILSVWQWQWGHLLGKVATLHDDLTGASFHPLDDNLLITH GKGHLTFWTRRKDGFFERTDIIKPPSRTHVTSIQFEQDGDVVTADGDGFI TIYSVDSDGAYFVRMEFEAHNKGISSLVMLSEGTLLSGGEKDRKIVAWDS LQNYKKITETKLPESAGGVRSIYPQRPGRNDGNIYVGTTRNNIMEGSLQR RFNQVVFGHGRQLWGLAVHPDDELFATAGHDKNIALWNRQKLIWST---Q I------------------------------------------AYECVSL SFHPFGVALAAGSTEGHLVVLNAESGAPAATIRVCGSPLSCIGYNPAGDM IAIGSQNGSVYLFRVSRDGFSYKKSNKIRGTQALNHMDWSTDGNYLQTVT GDYDLAFWDVKSMTAEKSPISMKDVKWYTLNCTVGFLVAGIWNNRFYPTT SVITTVNRSMAHDMLICGDADGYIRLFKYPCLSAKAEYNEDKVYSLQVAC ARFLFNDKYVVTVGGTDAALMLWDVVED >Tce xxxx---------xxx---------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ----------------------------------------xxxxxxxxxx xxxx---------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ------------------------------AASYGKKNGVWYGVPASTSS QGWSKPPLSRKASIVETEAPPPGGGNSTKPSSGRVIRIINNLDHSVQCRV LLNLRTSQPFEEVLEDLGQVLKMNGAKRMYTVNGQEVRSFSQLRNEFADV DTFYLSSNYGLSSPVRRSRSRAASHGPLVEDLTIRDVSRQRRARSKSRGR VLYADTDLVRGNDYTLVEVMKEEPVRVTIRGLRRT--------------- -------------------------------------------------- -------xx----------------------------------------- -----------------------------------------xxxxxxxxx xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx-xxxxxxxxxxx xxxRAGRNRKTQAHIRIWSTETLLTLYVFGMGEFDLGVSAVAFSQLNGGS YVLAVDGGRERILSVWQWQWGHLLGKVATLHDDLTGASFHPLDDNLLITH GKGHLTFWTRRKDGFFERTDIIKPPSRTHVTSIQFEQDGDVVTADGDGFI TIYSVDSDGAYFVRMEFEAHNKGISSLVMLSEGTLLSGGEKDRKIVAWDS LQNYKKITETKLPESAGGVRSIYPQRPGRNDGNIYVGTTRNNIMEGSLQR RFNQVVFGHGRQLWGLAVHPDDELFATAGHDKNIALWNRQKLIWST---Q I------------------------------------------AYECVSL SFHPFGVALAAGSTEGHLVVLNAESGAPAATIRVCGSPLSCIGYNPAGDM IAIGSQNGSVYLFRVSRDGFSYKKSNKIRGTQALNHLDWSTDGNYLQTVT ADYDLAFWDVKSMTAEKSPISMKDVKWYTLNCTVGFLVAGIWNNRFYPTT SVITTVNRSMAHDMLVCGDADGYIRLFKYPCLSAKAEYNEDKVYSLQVAC ARFLFNDKYVVTVGGTDAALMLWDVVED >Tsi ---xxxxxxxxxxx------------------------------------ -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -----------------------------QAASYGKKNGVWYGVPASTSS QGWSKPPLSRKASIVETEAPPPGGGNSTKPSSGRVIRIINNLDHSVQCRV LLNLRTSQPFEEVLEDLGQVLKMNGAKRMYTVNGQEVRSFSQLRNEFADV DTFYLSSNYGLSSPVRRSRSRAASHGPLVEDLTIRDVSRQRRARSKSRGR VLYADTDLVRGN-------------------------------------- -------------------------------------------------- --------xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx xxxRAGRNRKTQAHIRIWSTETLLTLYVFGMGEFDLGVSAVAFSQLNGGS YVLAVDGGRERILSVWQWQWGHLLGKVATLHDDLTGASFHPLDDNLLITH GKGHLTFWTRRKDGFFERTDIIKPPSRTHVTSIQFEQDGDVVTADGDGFI TIYSVDSDGAYFVRMEFEAHNKGISSLVMLSEGTLLSGGEKDRKIVAWDS LQNYKKITETKLPESAGGVRSIYPQRPGRNDGNIYVGTTRNNIMEGSLQR RFNQVVFGHGRQLWGLAVHPDDELFATAGHDKNIALWNRQKLIWST---Q Vxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx------- ----------------------------------------------AGDM IAIGSQNGSVYLFRVSRDGFSYKKSNKIRGTQALNHMDWSTDGNYLQTVT GDYDLAFWDVKSMTAEKSPISMKDVKWYTLNCTVGFLVAGIWNNRFYPTT SVITTVNRSMAHDMLICGDADGYIRLFKYPCLSAKAEYNEDKVYSLQVAC ARFLFNDKYVVTVGGTDAALMLWDVVED >Tms ---x-----------xxPVERPGQPLEEDSHFQRCVREVTISSAPSGVEY SLHGDRSFGVFPASVLLLSHLNLSPFHLRHPRPSYRRWPYPNDDPYFVHG FQISSSGVSYESVYxxxxxxxxxxxLLPELFCEAVGLERDQTRRYFNKDV AASVSHASSDQPRVCxxxxxxxxxxxxxILSSANYGAEAHEHLSIAFIRD IKNNNKEAKxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx--------- ---------------------------SEDGPQDTSQDAPNGKSLLQVQH AGEDPATTPRSEQSGNQASQSSQRNNSGHHNHASNGLAASSRPGSALAVA NHHHRKSDTTEEDEED--EDEDEEERRRARPAVATTVVVASSKEGGFWRA TASRPTSPGGGAAMADNASEASSTMLPPARPKSRAEHKAANSKYSNLSYW RARRVTFYRNGDPFFPGVEFRFKPGRDISNLEALLDKLSLRMDLPHGARY VFTMDGERRMRLEELEDGSSYVVSSYKTFKAASYGKKNGVWYGVPASTSS QGWSKPPLSRKASIVETEAPPPGGGNSTKPSSGRVIRIINNLDHSVQCRV LLNLRTSQPFEEVLEDLGQVLKMNGAKRMYTVNGQEVRSFSQLRNEFADV DTFYLSSNYGLSSPVRRSRSRAASHGPLVEDLTIRDVSRQRRARSKSRGR VLYADTDLVRGNDYTLVEVMKEEPVRVTIRGLRRTFYPPLHHPxYDNAPP EKRLQxNxx----------------------------------------- -------------------------------------------------- ---------------------------------------xxxxxxxxxxx xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx-xxxxxxxxxxx xxxRAGRNRKTQAHIRIWSTETLLTLYVFGMGEFDLGVSAVAFSQLNGGS YVLAVDGGRERILSVWQWQWGHLLGKVATLHDDLTGASFHPLDDNLLITH GKGHLTFWTRRKDGFFERTDIIKPPSRTHVTSIQFEQDGDVVTADGDGFI TIYSVDSDGAYFVRMEFEAHNKGISSLVMLSEGTLLSGGEKDRKIVAWDS LQNYKKITETKLPESAGGVRSIYPQRPGRNDGNIYVGTTRNNIMEGSLQR RFNQVVFGHGRQLWGLAVHPDDELFATAGHDKNIALWNRQKLIWST---Q I------------------------------------------AYECVSL SFHPFGVALAAGSTEGHLVVLNAESGAPAATIRVCGSPLSCIGYNPAGDM IAIGSQNGSVYLFRVSRDGFSYKKSNKIRGTQALNHLDWSTDGNYLQTxx -------------------------------------------------- -------------------------------------------------- ---------------------------- >Tpa ---x---------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ----------------------------------xxx------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------xxxxxxQ I------------------------------------------AYECVSL TFHPFGVALAAGSTEGHLVVLNAESGAPAATIRVCGSPLSCIGYNPAGDM IAIGSQNGSVYLFRVSRDGFSYKKSNKIRGTQALNHLDWSTDGNYLQTVT ADYDLAFCE------------------xxxxxxxxx-------------- -------------------------------------------------- ----------------------------