>Tge Mx------------------------------------------------ -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ---------------------xxxxxxxxxxxxxxxxxxxxxxxxxxxx- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ------------xxx----------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ----------------------TGLVYVFNLIVGTGALTLPAVFNQVGWA LGVSLIMVLAVISFITVTFVIESMAAANAIVQWKRLQQMKRVSHILQAAL QASESQDEDSEDTPLFSP-------------------------------- VGCSLFFVCFAVYLYGDLTIYSAAVSKx---------------------- -------------------------------------------------- L-------AVFLCTLGPFVFFNVQKTKYLQMLTTLMRW------------ -----LAFSIMIVYAARKLIYDGPQGHPPAASLSGVPGLFGACVYSFMCH HSLPALVSPIADKTRFSRFLALDYVLIAAFYLLLALTGAFAFQHLDDLYT LDFGPRANGDCGTGAAWPVMAMEYFLALFPVFTLSTSFPIIAITLRNNLK SLFLTEGCHYHWCIRKMVFPLLAVIPPVLIATTTENLEILVRVTGSYAGA SIQYIIPALLVYYARQKTLQVIGMGVKNEFASPFHGCGWVWFVILWAIAC SILVT--------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- VNFVQRLIxSNESDNWGPHKRSxxxxxxxxxxxxxRSELTLEEVNPHKRG GRxENxxxxxxxxxPxxxxxxxxxxxxxxxxxxxxxxxxRHRGGIPNx-- -------------------------------------------------- -------------------------------------------------- --- >Tms Mxxx---------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- --------------------------------------xxxxxxxxxxxx xxxxxxxxxxxxxxx----------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ----------------------TGLVYVFNLIVGTGALTLPSVFNQAGWA LGVSLIMVLAVISFITVTFVIESMAAANAIVQWKRLQQMKRVSHIIQAAL QASESQDEDSEDTPLFSPELLEKFPSTPHRYYLIQERIEMGQMATLFFSR FGCSLFFLCFAVYLYGDLTIYSAAVSKSL-----xxxxxAYHCDVPTLHV TTCRYQRSPFFPPLNxTYHPSDLPCNSTVPENAFCWEGSRLTRLDAYRIF L-------AVFLCTLGPFVFFNVQKTKYLQMLTTLMRW------------ -----LAFSIMIVYAARKLIYDGPQGHPPAASLSGVPGLFGACVYSFMCH HSLPALVSPIADKTRLSRFLALDYVLIAAFYLLLALTGAFAFQHLDDLYT LDFGPRANGDCGTGAAWPVMAMEYFLALFPVFTLSTSFPIIAITLRNNLK SLFLTEGRHYHWCIRKMAFPLLAVIPPVLIATTTENLEILVRVTGSYAGA SIQYIIPALLVYYARQKTLQVIGMGVKNEFASPFHSCGWVWFVILWAIAC SILVT--------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ------------------------------------------------xx xxxxxxxxYGHACDLVTVxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx xxxxVAHTCVRVAACRENTGHVCVCLCHPPLSISxxxLANRSVFTAxxxx xxx >Tce MAEE---------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- --------------------------------------xxxxxxxxxxxx xxxxxxxxxxxxxxx----------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ----------------------TGLVYVFNLIVGTGALTLPSVFNQAGWA LGVSLIMVLAVISFITVTFVIESMAAANAIVQWKRLQQMKR-------AL QASESQDEDSEDTPLFSPELLEKFPSTPHRYYLIQERIEMGQMATLFFSR FGCSLFFLCFAVYLYGDLTIYSAAVSKSLVDVAx---------------- ----------------TYHPSDLPCNSTVPENAFCWEGSRLTRLDAYRIF L-------AVFLCTLGPFVFFNVQKTKYLQILTTLMRW------------ -----LAFSIMIVYAARKLIYDGPQGHPPAASLSGVPGLFGACVYSFMCH HSLPALVSPIADKTRLSRFLALDYVLIAAFYLLLALTGAFAFQHLDDLYT LDFGPRANGDCGTGAAWPVMTMEYFLALFPVFTLSTSFPIIAITLRNNLK SLFLTEGRHYHWCIRKMAFPLLAVIPPVLIATTTENLEILVRVTGSYAGA SIQYIIPALLVYYARQKTLQVIGMGVKNEFASPFHSCGWVWFVILWAIAC SILVT--------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- VNFIQRLI------------------------------------------ -----------------------------------------------V-- -------------------------------------------------- -------------------------------------------------- --- >Tps MCDEEVAALVVDNGSGMCKAGFAGDDAPRAVFPSIVGRPRH--------- ----------------------------QGVMVGMGQKDSYVGDEAQSKR GILTLKYPIEHGIVTNWDDMEKIWHHTFYNELRVAPEEHPVLLTEAPLNP KANREKMTQIMFETFNTPAMYVAIQAVLSLYAS----------------- -----GYALPHAILRLDLAGRDLTDYLMKILTERGYSFTTTAEREIVRDI KEKLCYVALDFEQEMATA-------------------------------- -------------------------------ASSSSLEKSYELPDGQVIT IGNERFRCPEALFQPSFLGMEACGIHETTYNSIMKCDVDIRKDLYANTVL SGGTTMYPGIADRMQKEITALAPSTMKIKIIAPPERKYSVWIGGSILASL STFQQMWISKQEYDESGPSI------------------------------ -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ----------------------TGLVYVFNLIVGTGALTLPSVFNQAGWA LGVSLIMVLAVISFITVTFVIESMAAANAIVQWKRLQQMKR-------AL QASESQDEDSEDTPLFSPELMEKFPSTPHRYYLIQERIEMGQMATLFFSR FGCSLFFLCFAVYLYGDLTIYSAAVSKSLVxxxx---------------- ----------------TYHPPDLPCNATVPENAFCWEGSRLTRLDAYRIF L-----------------------KTKYLQMLTTLMRW------------ -----LAFSIMIVYAARKLIYDGPQGHPPAASLSGVPGLFGACVYSFMCH HSLPALVSPIADKTRLSRFLALDYVLIAAFYLLLALTGAFAFQHLDDLYT LDFGPRANGDCGTGAAWPVMAMEYFLALFPVFTLSTSFPIIAITLRNNLK SLFLTEGCHYHWCIRKLAFPLLAVIPPVLIATTTENLEILVRVTGSYAGA SIQYIIPALLVYYARQKTLQVIGMGVKNEFASPFHSCGWVWFVILWAIAC SILVT--------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- VNFVQRLI------------------------------------------ -----------------------------------------------V-- -------------------------------------------------- -------------------------------------------------- --- >Tte -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- --------------AARKLIYDGPQGHPPAASLSGVPGLFGACVYSFMCH HSLPALVSPIADKTRLSRFLALDYVLIAAFYLLLALTGAFAFQHLDDLYT LDFGPRANGDCGTGAAWPVMAMEYFLALFPVFTLSTSFPIIAITLRNNLK SLFLTEGC------------------------------------------ -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- --- >Tbi xxxxEVAALVVDNGSGMCKAGFAGDDAPRAVFPSIVGRPRH--------- ----------------------------QGVMVGMGQKDSYVGDEAQSKR GILTLKxxIEHGIVTNWDDMEKIWHHTFYNELRVAPEEHPVLLTEAPLNP KANREKMTQIMFETFNTPAMYVAIQAVLSLYASGRTTGIVLDSGDGVSHT VPIYEGYALPHAILRLDLAGRDLTDYLMKILTERGYSFTTTAEREIVRDI KEKLCYVALDFEQEMATA-------------------------------- -------------------------------ASSSSLEKSYELPDGQVIT IGNERFRCPEALFQPSFLGMEASGIHETTYNSIMKCDVDIRKDLYANTVL SGGTTMYPGIADRMQKEITALAPSTMKIKIIAPPxxxxxxWxxxxxxxxx xxxxxxxxxKQEYDExxxxxLRLDLAGRDLTDYLMKILTERGYSFTTTAE REIVRDIKEKLCYVALDFEQEMATAxxxxxxxxxxxxxxxxxxxxxxxxx xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx----------- --------------xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx xxxxxxxxxxxxxxxxxxxxxxxx-------------------------- ----------------------xxxxxxxxxxxxxxxxxRK--------- --------------------------------------------RVDVPV xSxxxWxxxxxxxxxYxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx xxxxxxxxxxxxxxxxxxxxxxTGLVYVFNLIVGTGALTLPAVFTQAGWA LGVSLIMVLAVISFITVTFVIESMAAANAIVQWKRLQQMKRVSHILQAAL QASESQDEDSEDTPLFSPELLEKFPSTPHRYYLIQERIEMGQMATLFFSR FGCSLFFVCFAVYLYGDLTIYSAAVSKSLVxxx----------------- -------------------------------------------------- -------------------------------------xxxxxxxxxxxxx xxxxxPAFSIMIVYAARKLIYDGPQGHPPAASLSGVPGLFGACVYSFMCH HSLPALVSPIADKTRLSRFLALDYVLIAAFYLLLALTGAFAFQHLDDLYT LDFGPRANGDCGTGAAWPVMAMEYFLALFPVFTLSTSFPIIAITLRNNLK SLFLTEGCHYHWCIRKVVFPLLAVIPPVLIATTTENLEILVRVTGSYAGA SIQYIIPALLVYYARQKTLQVIGMGVKNEFASPFHSCGWVWFVILWAIAC TILVTxxxxxxxxxGNLHLDGGRLxxxxxxxTPCSADQDSNLDLLVLGRL AQHETSALANxxTxxxxxxxxxDNWxxxxxxxxxxxxxxxxxxxxxxxxx xxxxxxxxxxxxxxxxDNxxxxxxxxxAGxxxxxxxxxxxxxxxxxxxxE AQSKRGILTxKYPIEHGIVTNWDDMEKIWHHTFYNELRVAPEEHPVLLTE APLNPKANREKMTQIMFETFNTPAMYVAIQAVLSLYASGRTTGIVLDSGD GVSHTVPIYEGYALPHAILRLDLAGRDLTDYLMKILTERGYSFTTTAERE IVRDIKEKLCYVAxxxxxxMATAxxxxSLEKSYELPDGQVITIGNERFRC PEALFQPSFLGMEASGIHETTYNSIMKCDVDIRKDLYANTVLSGGTTMYP GIADRMQKEITALAPSTMKIKIIAPPERKYSVWIGGSILxSLSTFQQMWI SKQEYDESGPAILRLDLAGRDLTDYLMKILTERGYSFTTTAxxxxxRDIK EKLCYVALDFEQEMATAASSSSLEKSYELPxxxVITIGNERFRxxxxxxx xSFLGMEASGIHETTYxxxxxCDVDIRKDLYANTVLSGGTTMYPGIADRM QKEITALAxxxMKIxIIAxxxxKYSVWIGGSxxxxxxxxxxxxxxxxxxx xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx x------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- --- >Tdi x---EVAALVVDNGSGMCKAGFAGDDAPRAVFPSIVGRPRHxTMDPVCAK LVLLETMHPGLYSPPSLGDQGIxxxxxxQGVMVGMGQKDSYVGDEAQSKR GILTLKYPIEHGIVTNWDDMEKIWHHTFYNELRVAPEEHPVLLTEAPLNP KANREKMTQIMFETFNTPAMYVAIQAVLSLYASGRTTGIVLDSGDGVSHT VPIYEGYALPHAILRLDLAGRDLTDYLMKILTE---TFTTTAEREIVRDI KEKLCYVALDFEQEMATAxxxx--------------------------xx xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxASSSSLEKSYELPDGQVIT IGNERFRCPEALFQPSFLGMEACGIHETTYNSIMKCDVDIRKDLYANTVL SGGTTMYPGIADRMQKEITALAPSTMKIKIIAPPERKYSVWIGGSILASL STFQQMWISKQEYDESGPSI------------------------------ -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------VHRKKVTCQAxIx xxECxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx----- -------------------------------------------------- ----------------------TGLVYVFNLIVGTGALTLPSVFNQAGWA LGVSLIMVLAVISFITVTFVIESMAAANAIVQWKRLQQMKRVSHIIQAAL QASESQDEDSEDTPLFSPELMEKFPSTPHRYYLIQERIEMGQMATLFFSR FGCSLFFLCFAVYLYGDLTIYSAAVSN----------------------- ----------------TYHPPDLPCNATVPENAFCWEGSRLTRLDAYRIF L-------AVFLCTLGPFVFFNVQKTKYLQMLTTLMRW------------ -----LAFSIMIVYAARKLIYDGPQGHPPAASLSGVPGLFGACVYSFMCH HSLPALVSPIADKTRLSRFLALDYVLIAAFYLLLALTGAFAFQHLDDLYT LDFGPRANGDCGTGAAWPVMAMEYFLALFPVFTLSTSFPIIAITLRNNLK SLFLTEGRHYHWCIRKLAFPLLAVIPPVLIATTTENLEILVRVTGSYAGA SIQYIIPALLVYYARQKTLQVIGMGVKNEFASPFHSCGWVWFVILWAIAC SILVT--------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- VNFVQRLI------------------------------------------ -----------------------------------------------V-- -------------------------------------------------- -------------------------------------------------- --- >Tcm Mx--EVAALVVDNGSGMCKAGFAGDDAPRAVFPSIVGRPRH--------- ----------------------------QGVMVGMGQKDSYVGDEAQSKR GILTLKYPIEHGIVTNWDDMEKIWHHTFYNELRVAPEEHPVLLTEAPLNP KANREKMTQIMFETFNTPAMYVAIQAVLSLYASGRTTGIVLDSGDGVSHT VPIYEGYALPHAILRLDLAGRDLTDYLMKILTERGYSFTTTAEREIVRDI KEKLCYVALDFEQEMATA-------------------------------- -------------------------------ASSSSLEKSYELPDGQVIT IGNERFRCPEALFQPSFLGMEASGIHETTYNSIMKCDVDIRKDLYANTVL SGGTTMYPGIADRMQKEITALAPSTMKIKIIAPPERKYSVWIGGSILASL STFQQMWISKQEYDESGPSI------------------------------ -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ----------------------TGLVYVFNLIVGTGALTLPSVFNQAGWA LGVSLIMVLAVISFITVTFVIESMAAANAIVQWKRLQQMKRVSHIIQAAL QASESQDEDSEDTPLFSPELLEKFPSTPHRYYLIQERIEMGQMATLFFSR FGCSLFFLCFAVYLYGDLTIYSAAVSN----------------------- ----------------TYHPSDLPCNSTVPENAFCWEGSRLTRLDAYRIF -------------------------------------------------- -----xAFSIMIVYAARKLIYDGPQGHPPAASLSGVPGLFGACVYSFMCH HSLPALVSPIADKTRLSRFLALDYVLIAAFYLLLALTGAFAFQHLDDLYT LDFGPRANGDCGTGAAWPVMAMEYFLALFPVFTLSTSFPIIAITLQNNLK SLFLTEGRHYHWCIRKMAFPLLAVIPPVLIATTTENLEILVRVTGSYAGA SIQYIIPALLVYYARQKTLRVIGMGVKNEFASPFHNCGWVWFVILWAIAC SILVT--------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- VNFVQRLI------------------------------------------ -----------------------------------------------V-- -------------------------------------------------- -------------------------------------------------- --- >Tpa x------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- xxxxxxxxAVFLCTLGPFVFFNVQKTKYLQMLTTLMRW------------ -----LAFSIMIVYAARKLIHDGPQGHPPAASLSGVPGLFGACVYSFMCH HSLPALVSPIADKTRLSRFLALDYVLIAAFYLLLALTGAFAFQHLDDLYT LDFGPRANGDCGTGAAWPVMAMEYFLALFPVFTLSTSFPIIAITLRNNLK SLFLTEGCHYHWCIRKMVFPLLAVIPPVLIATTTENLEILVRVTGSYAGA SIQYIIPALLVYYARQKTLQVIGMGVKNEFASPFHSCGWVWFVILWAIAC SILVT--------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- VNFVQRLI------------------------------------------ -----------------------------------------------V-- -------------------------------------------------- -------------------------------------------------- --- >Tsi x------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -----------------------xxxxxxxxxxxxxxxxxxxxxxxxxxx xxxxxxxxxxxxxxxxxxxxxxxxxx------------------------ -------------------------------------------------- -------------------------------------------------- ----------------------TGLVYVFNLIVGTGALTLPSVFNQAGWA LGVSLIMVLAVISFITVTFVIESMAAANAIVQWKRLQQMKR-------AL QASESQDEDSEDTPLFSP-------------------------------- VGCSLFFLCFAVYLYGDLTIYSAAVSKSLVDVAx---------------- ----------------TYHPSDLPCNSTVPENAFCWEGSRLTRLDAYRIF L-------AVFLCTLGPFVFFNVQKTKYLQMLTTLMRW------------ -----LAFSIMIVYAARKLIYDGPQGHPPAASLSGVPGLFGACVYSFMCH HSLPALVSPIADKTRLSRFLALDYVLIAAFYLLLALTGAFAFQHLDDLYT LDFGPRANGDCGTGAAWPMMAMEYFLALFPVFTLSTSFPIIAITLQNNLK SLFLTEGRHYHWCIRKMAFPLLAVIPPVLIATTTENLEILVRVTGSYAGA SIQYIIPALLVYYARQKTLRVIGMGVKNEFASPFHNCGWVWFVILWAIAC SILVT--------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- VNFVQRLI------------------------------------------ -----------------------------------------------x-- -------------------------------------------------- -------------------------------------------------- ---