>Tge -----------MAGSLPYPWLPIPREDCIGLxxxxxxxxxxxx------- --------L----------------------------------------- ----------------------DGNVTASKSLFKGSQIFIQITCEAEEPT AASITIRWILIQSVCWEDFLQFGDGTMEKSDRPTFAHSTDNRSHFIEYKD KEYQCAGHVVLEEYSDKQTISAPPAELKxGEKEAKNSNSVPASGDTNVSN QQPKTKRDGVGTENNTALKIQSVKNVLNPSKI--------------PGDH PVYTIPADGVYMLILFISSRGRYNASIQIEMQGKYGYLSAADWPLLPFYG GMCLVYVVLGLAWLVISFCQWRDLLRIQFWIGGVILLGMLEK-------- -------------------------------------------------A TFYAEYQSINATGMSVKGAVLLAEIVSCGKRTLARMLVIIVSLGFGIVKP RLGPMLHRVVGTGGLYFILASVESYLRVMHPKNDPSNQIFIASVPLAVLD SAICWWIFTSLVQTTRTLRL-------------------RR--------- ----------------------------------------NLVKLSLYRH FTNTLIFAVIASVVFMLYSIKYHKMVLCLTDWKELWVDEACWHILFSVLL LVIMILWRPTNNNQRYAFTPLLDAPEDDEDEEEQFVNDAFGVKMRGFRSN SPKPKSSNSVEEDLKWVEDNIPSSMGDT---------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ------------------------------------YLP----------- ----GMSSPGSGEGTQ---PYDVTQFYIGLGLAVSSSVFIGSSFIIKKKA LLRLNRTGSVRAGAGGFGYLKEWVWWAGLLTMGVGEAANFAAYAFAPASL VTPLGALSVLVAAVLSSKFLNEKLNLLGKMGCFLCVLGSTIIVIHSPKDE EIESLDILLQKLQDPGFESYIVLVLIISVVIAFYVGPKYGHKNVAVYIIL CSLIGSLTVMSCKGLGLALKDTISGQSNEMGNWLTWAFLLTVLVCITVQM NYLNKSLDLFNTGIVTPVYYVFFTTLVIVASAILFREWTSLSAQDMIGSI CGFLTVIVAIILLNAFRDMEISLAD------------------------- ------------------xxxxxx-------------------------- -------------x >Tpa -----------MAGSLPYPWLPIPREDFISLxxxxxxxxxxxx------- --------L----------------------------------------- ----------------------DGNVTASKSLFKGSQIFIQITCEAEEPT AASITIRWILIQSVCWEDFLQFGDG------------------------- -----------EEYSDKQTISAPPAELKxGEKEAKNSNSVPASGDTNVSN QQPKTKRDGVGTENNTALKIQSVKNVLNPSKI--------------PGDH PVYTIPADGVYMLILFISSRGRYNASIQIEMQGKYGYLSAADWPLLPFYG GMCLVYVVLGLAWLVISFCQWRDLLRIQFWIGGVILLGMLEK-------- -------------------------------------------------A TFYAEYQSINATGMSVKGAVLLAEIVSCGKRTLARMLVIIVSLGFGIVKP RLGPMLHRVVGTGGLYFILASVESYLRVMHPKNDPSNQIFIASVPLAVLD SAICWWIFTSLVQTTRTLRL-------------------R---------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------- >Tbi -----------MxxxxxxxxxxxxxxDxxxLxxxxxxxxxxxx------- --------L----------------------------------------- ----------------------DGNVTASKSLFKGSQIFIQITCEAEEPT AASITIRWILIQSVCWEDFLQFGDGTMEKSDRPTFAHATDNRSHFIEYKD KDYQCAGHVVLEEYSDKQTISAPPAELKxGEKEAKNSNSVPASSNSNVSN QQSKTKRDSVGTETNTALKTQSVKNVLNPSKI--------------PGDH PVYTIPADGVYMLILFISSRGRYNASIQIEMQGKYGYLSAADWPLLPFYG GMCLVYVVLGLAWLVISFCQWRDLLRIQFWIGGVILLGMLEK-------- -------------------------------------------------A TFYAEYQSINATGMSVKGAVLLAEIVSCGKRTLARMLVIIVSLGFGIVKP RLGPMLHRVVGTGGLYFILASVESYLRVMHPKNDPSNQIFIASVPLAVLD SAICWWIFTSLVQTTRTLRL-------------------RR--------- ----------------------------------------NLVKLSLYRH FTNTLIFAVIASVVFMLYSIKYHKMVLCLTDWKELWVDEACWHILFSVLL LVIMILWRPTNNNQRYAFTPLLDAPEDDEDEEEQFVNDAFGVKMRGFRSN SPKPKSSNSVEEDLKWVEDNIPSSMGDT---------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ------------------------------------YLP----------- ----GMSSPGSGEGTQ---xYDVTQFYIGLGLAVSSSVFIGSSFIIKxxA LLxxxxxxxxxxxxxxxxYLKEWVWWAGLLTMGVGEAANFAAYAFAPASL VTPLGALSVLVAAVLSSKFLNEKLNLLGKMGCFLCVLGSTIIVIHSPKDE EIESLDILLQKLQDPGFESYIVLVLIISVVIAFYVGPxYGxxxxxVYIIL CSLIGSLTVMSxKGLGLALKDTISGQSNEMGNWLTWAFLLTVLVxITVQM NYLNKSLDLFNTGIVTPVYYVFFTTLVIVASAILFREWTSLSAQDMIGSI CGFLTVIVAIILLNAFRDMEISLADVRGIMRPKRELLPISKHQEVYEDEE GLIGGQAPSYGSPGITRSx------------------------------- -------------- >Tte xxxxxxxxxxxx-------------------------------------- --------L----------------------------------------- ----------------------DGNVTASKSLFKGSQIFIQITCEAEEPT AASITIRWILIQSVCWEDFLQFGDGTMEKSDRPTFAHATDNRSHFIEYKD KDYQCAGHVVLEEYSDKQTISAPPAELKxGEKEAKNSNSVPASSNSNVSN QQSKTKRDSVGTETNTALKTQSVKNVLNPSKI--------------PGDH PVYTIPADGVYMLILFISSRGRYNASIQIEMQGKYGYLSAADWPLLPFYG GMCLVYVVLGLAWLVISFCQWRDLLRIQFWIGGVILLGMLEK-------- -------------------------------------------------A TFYAEYQSINATGMSVKGAVLLAEIVSCGKRTLARMLVIIVSLGFGIVKP RLGPMLHRVVGTGGLYFILASVESYLRVMHPKNDPSNQIFIASVPLAVLD SAICWWIFTSLVQTTRTLRL-------------------RR--------- ----------------------------------------NLVKLSLYRH FTNTLIFAVIASVVFMLYSIKYHKMVLCLTDWKELWVDEACWHILFSVLL LVIMILWRPTNNNQRYAFTPLLDAPEDDEDEEEQFVNDAFGVKMRGFRSN SPKPKSSNSVEEDLKWVEDNIPSSMGDT---------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ------------------------------------YLP----------- ----GMSSPGSGEGTQ---PYDVTQFYIGLGLAVSSSVFIGSSFIIKKKA LLRLNRTGSVRAGAGGFGYLKEWVWWAGLLTMGVGEAANFAAYAFAPASL VTPLGALSVLVAAVLSSKFLNEKLNLLGKMGCFLCVLGSTIIVIHSPKDE EIESLDILLQKLQDPGFESYIVLVLIISVVIAFYVGPKYGHKNVAVYIIL CSLIGSLTVMSCKGLGLALKDTISGQSNEMGNWLTWAFLLTVLVCITVQM NYLNKSLDLFNTGIVTPVYYVFFTTLVIVASAILFREWTSLSAQDMIGSI CGFLTVIVAIILLNAFRDMEISLADVRGIMRPKRELLPISKHQEVYEDEE GLIGGQAPSYGSPGITRSM------------------------------- -------------- >Tms -----------M-------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------xxxxxxxxxxxxxxxxxxxx----- -------------------------------------------------- ---------------------------------------xxxxxxxxxxx --xxGMSSPGSDGGTQGAxxYDVTQFYIGLGLAVSSSVFIGSSFIIKKKA LLRLNRTGSVRAGAGGFGYLKEWVWWAGLLTMGVGEAANFAAYAFAPASL VTPLGALSVLVAAVLASKFLNEKLNLLGKMGCFLCVLGSTIIVIHSPKDE EIESLDILLQKLQDPGFESYIVLVLIISVVIAFYVGPKYGHKNVAVYIIL CSLVGSLTVMSCKGLGLALKDTISGQSNEMGNWLTWVFLLTVLVCITVQM NYLNKSLDLFNTGIVTPVYYVFFTTLVIVASAILFREWTSLSAQDMIGSI CGFLTVIVAIILLNAFRDMEISLADVRGIMRPKRELLPISKHQEVYEDEE GLIGGHAPTYGSPGMTRSM------------------------------- -------------- >Tce -----------M-------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------xxxxxxxxxxxxxxxxxxxx----- -------------------------------------------------- ---------------------------------------xxxxxLTPYMY xxxxGMSSPGSDGGTQGxxxYDVTQFYIGLGLAVSSSVFIGSSFIIKKKA LLRLNRTGSVRAGAGGFGYLKEWVWWAGLLTMGVGEAANFAAYAFAPASL VTPLGALSVLVAAVLASKFLNEKLNLLGKMGCFLCVLGSTIIVIHSPKDE EIESLDILLQKLQDPGFESYIVLVLIISVVIAFYVGPKYGHKNVAVYIIL CSLVGSLTVMSCKGLGLALKDTISGQSNEMGNWLTWVFLLTVLVCITVQM NYLNKSLDLFNTGIVTPVYYVFFTTLVIVASAILFREWTSLSAQDMIGSI CGFLTVIVAIILLNAFRDMEISLADVRGIMRPKRELLPISKHQEVYEDEE GLIGGHAPTYGSPGMTRSM------------------------------- -------------- >Tsi -----------x-------------------------------------- -------------------------------------------------- -----------------------------------------ITCEAEEPT AASITIRWILIQSVCWEDFLQFDDGTMEKSDRPTFAHATDNRSHFIEYKD KVYQCAGHIVLEEYSDKQTISAPPAELK-----AKNSDSLPANDDTNVSN QQSKTKRDSVGTENNTTLKTQSVKNVLNPSKILHIFKGPIHRRMFQPGDH PVYTIPADGVYMLVLFISSRGRYNASVQIEMQGKYGYLSAADWPLLPFYG AMCLVYVVLGLAWLVISFCQWRDLLRIQFWIGGVILLGMLEKFTLYTAAT GQRANGCLLKKINCFSAQSPDLGFILSEPIREERETRNATSRKRKPKKAA TFYAEYQSINATGMSVKGAVLLAEIVSCGKRTLARMLVIIVSLGFGIVKP RLGPMLHRVVGTGGLYFVLASVESYLRVMHPKNDPSNQIFIASVPLAVLD SAICWWIFTSLVQTTRTLRL-------------------RRLVxxxxxxx xxTLTTELSRSCPExxVIxxxxxxxExxxxxxxxxxxxExNLVKLSLYRH FTNTLIFAVISSVVFMLYSIKYHKMVLCLTDWKELWVDEACWHILFSVLL LVIMILWRPTNNNQRYAFTPLLDAPEDDEDEEEQFVNDAFGVKMRGFRSN SPKPKSSNSVEEDLKWVEDNIPSSMGDT---------------------- -xxxxxxxxxxxxxxxSLLIERAPQVTPLPTCLSARPAFIPVLNRSTxRP VVSVVLASVRFDPDTWEPQVVDLRHPMVLEGAVALVIHNTDIMPVTRSIS RILRWPTTIAGISFKKMTPVEVRSTIIPGPASTAGRILQRITLANIRATA SCFVSIAEPGSWETHLFLHVQSFRGGGGFGADSWPISAFVQDLVELSDQE EQDPAEDQVHSRPKRNRKPPIWMSDYDVNTAANTMSSQRKKTRTATLHSL ILTLLLSGGEGELQGVVGGTGSCGxRRIYGLNVRDRRGITIPYRYxxxxx HRMCMIPYRYCLAPYVxxTIPLLSGTVRVxxxxxxxLAPYVYDTIPLLSW HRTCTILCWCARTSTRKRRDTCTCDDMC-------RYLP----------- ----GMSSPGSDGGAQxxxxYDVTQFYIGLGLAVSSSVFIGSSFIIKKKA LLRLNRAGSVRAGAGGFGYLKEWVWWAGLLTMGVGEAANFAAYAFAPASL VTPLGALSVLVAAVLASKFLNEKLNLLGKMGCFLCVLGSTIIVIHSPKDE EIESLDILLQKLQDPGFESYIVLVLIISVVIAFYVGPRYGHKNVAVYIIL CSLVGSLTVMSCKGLGLALKDTISGQSNEMGNWLTWVFLLTVLVCITVQM NYLNKSLDLFNTGIVTPVYYVFFTTLVIVASAILFREWTSLSAQDMIGSI CGFLTVIVAIILLNAFRDMEISLADVRGILRPKRELLPTSKHQEVYEDEE GLIGGHAPTYGSPGMTRSM------------------------------- -------------- >Tps -----------M-------------------------------------- --------xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx------ ----------------------DANVTASKSLFKGSQIFIQITCEAEEPT AASITIRWILIQSVCWEDFLQFDDGTMEKSDRPTFAHATDNRSHFIEYKD KVYQCAGHIVLEEYSDKQTISAPPAELK-----AKNSDSVPANSDTNVLN QQSKTKRDSVGTESNTTLKTQSVKNVLNPSKI--------------PGDH PVYTIPADGVYMLVLFISSRGRYNASVQIEMQGKYGYLSAADWPLLPFYG AMCLVYVVLGLAWLIISFCQWRDLLRIQFWIGGVILLGMLEK-------- -------------------------------------------------A TFYAEYQSINATGMSVKGAVLLAEIVSCGKRTLARMLVIIVSLGFGIVKP RLGPMLHRVVGTGGLYFVLASVESYLRVMHPKNDPSNQIFIASVPLAVLD SAICWWIFTSLVQTTRTLRLxxAIPSRCKQLNHEVFVISRR--------- ----------------------------------------NLVKLSLYRH FTNTLIFAVISSVVFMLYSIKYHKMVLCLTDWKELWVDEACWHILFSVLL LVIMILWRPTNNNQRYAFTPLLDAPEDDEDEEEQFVNDAFGVKMRGFRSN SPKPKSSNSVEEDLKWVEDNIPSSMGDT---------------------- -x------------------------------------------------ -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------xx----------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -----------------------xxxxxxxxxxxxxxxxxxxxxxxxxxx xxxxxxxxxxxxxx >Tdi -----------x-------------------------------------- -------------------------------------------xxxxxxx xxxxxxxxxxxxxxxxxxxxxxDANVTASKSLFKGSQIFIQITCEAEEPT AASITIRWILIQSVCWEDFLQFDDGTMEKSDRPTFAHATDNRSHFIEYKD KVYQCAGHIVLEEYSDKQTISAPPAELK-----AKNSDSVPANGDTNVLN QQSKTKRDSVGTENNTTLKTQSVKNVLNPSKI--------------PGDH PVYTIPADGVYMLVLFISSRGRYNASVQIEMQGKYGYLSAADWPLLPFYG AMCLVYVVLGLAWLIISFCQWRDLLRIQFWIGGVILLGMLEK-------- -------------------------------------------------A TFYAEYQSINATGMSVKGAVLLAEIVSCGKRTLARMLVIIVSLGFGIVKP RLGPMLHRVVGTGGLYFVLASVESYLRVMHPKNDPSNQIFIASVPLAVLD SAICWWIFTSLVQTTRTLRLxxAIPSRCKQLNHEVFVISRR--------- ----------------------------------------NLVKLSLYRH FTNTLIFAVISSVVFMLYSIKYHKMVLCLTDWKELWVDEACWHILFSVLL LVIMILWRPTNNNQRYAFTPLLDAPEDDEDEEEQFVNDAFGVKMRGFRSN SPKPKSSNSVEEDLKWVEDNIPSSMGDTxxxxxxxxxxxxxxxxxxxxxx x------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -----------------------------xxxxxxxxxxxxxxxxxxxxx xxxxxxxxxxxxxx >Tcm -----------Mx-----------------------------xxxxxxxx xxxxxxxxL----------------------------------------- ----------------------DANVTASKSLFKGSQIFIQITCEAEEPT AASITIRWILIQSVCWEDFLQFDDGTMEKSDRPTFAHATDNRSHFIEYKD KVYQCAGHIVLEEYSDKQTISAPPAELK-----AKNSDSLPANDDTNVSN QQSKTKRDSVGTENNTTLKTQSVKNVLNPSKI--------------PGDH PVYTIPADGVYMLVLFISSRGRYNASVQIEMQGKYGYLSAADWPLLPFYG AMCLVYVVLGLAWLVISFCQWRDLLRIQFWIGGVILLGMLEK-------- -------------------------------------------------A TFYAEYQSINATGMSVKGAVLLAEIVSCGKRTLARMLVIIVSLGFGIVKP RLGPMLHRVVGTGGLYFVLASVESYLRVMHPKNDPSNQIFIASVPLAVLD SAICWWIFTSLVQTTRTLRL-------------------RR--------- ----------------------------------------NLVKLSLYRH FTNTLIFAVISSVVFMLYSIKYHKMVLCLTDWKELWVDEACWHILFSVLL LVIMILWRPTNNNQRYAFTPLLDAPEDDEDEEEQFVNDAFGVKMRGFRSN SPKPKSSNSVEEDLKWVEDNIPSSMGDT---------------------- -x---------------------------------------------xxx xxxxxxxxxxxxxxxxxxxxxxx--------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ---------------------------xxxxxxxxxxx------------ -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- --------------