>Tge -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- --AECRRK-----NRRTNSLLHGTTASSDSDGEDSDCLVGSLWITKGPPA KLDAPPRKLRFLRMFGLTTLSRRNELELRKLERRRCPLVVAVEEAHSEGA TPSPLDLPLPRYNPDQLSRTPDYKAKVRFLRSLGLECVARRDREDHELIW Q------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ---------------------------- >Tsi MxxxxSMDDSAPPSHRVCVxxxxxxxGxxxxxxxxxxxxxxxxxxxxxxx xxxxx--------------------------------------------F SSFPGDVNRTSPKPxxxQTTKxxxxxxxxxxxxxxxxxxxxxxxxxxxxx xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx--- -------------------------------------------------- -------------------------------------------------- ----------------------------L-----------KRESNESEPA PTRQVSPKTRGPPPLVRGSSPPPQDSQRKDRGLPHDGSRGSVSRPEDSHL YGARERAGVNVAVTEPQLLARSGFQPYRPEESRLGHPPAPPPPPTFTLDP AAAYNPYHPAAAAGLYPPHLQHAYRxPPEKFHKNKSGIELVVIDFLLRSN HYLFVGQSLGLGRLITDTPRMSIQNTAYRSSLARNKNEVAKRHVTPVRLL EEQLYLERCGMLRPPLFPALPPSYHPLYGLRYSPDMLHSPLGLISPGLHE RMKLEEEHRQRETQRMREEEKEREREQEREREKERRDKSRRSPRASPSHH QEAPARKAPIAGGRERAADPRKEPSPYPPPHLIVPGSIPNPTSVTLPPPL HPINSSLEAGHAVTRLPYPSTSPHHTSPGHAIVSSHNTHTPPIMPSH-TH TPPIMPSHTTHTSSILTSHNTHTSPIISPHNPHTHASPIHSMVPHTVTSH TLHPLAPPQGNPPQLQQSSHRTSNPSGRVAVKDPPPAFVRPFEDNYSQQR RSPAVAFSPVKDRT--SVSVVDQQVDSSVSSAVPKQPNTHHQHHHGAPTL EPPSPSVTRKDSIFPHTRGLAVSLSKDLSARVTVSENGPVKLSSCPRVSE GHTQESPLVSNDSHSHHHQPQQKLTVAVAPSYHAAPLSVNSQPPSQTFPP QPYHLSSQQQQHQQPMFPFSVSSQLNHSQPSPTLINSSLPTSASQPPSEH GVANLINHQPSSTTTIPVVSSHQTTRQTTVVQAIQPVPAVVTFHQPPAVL NVPDAAKVAAVSAKEAAVPMSVWDYHYLSRSINSQRSTVGDCHSLAVSKL DLAECRRK-----NRRTNSLLNGTTASSDSDGEDSDCLVGSLWITKGPPA KLDAPPRKLRFLRMFGLTTLSRRNELELRKLERRRCPLVVAVEEAHSEGA TPSPLDLPLPRYNPDQLSRTPDYKAKVRFLRSLGLECVARRDREDHELIW QTVIAERLRRNAVSSLVEYCRKVQLCTRGDPN-RDSPDRSERPRRVRLAF GIKRPASPDTLVVPGMNGLLRPSWLLSNGVKRLAVMEEDKGGEEEGPLRW PGLEAVMEAYHRYQQERSLEHRVLQDQCECLRNQLSARRREADTLDRRLR DLVATKSTQDYERHQTQRAIDHLNASLRQL-------------------- ---R---------------------------------------------- -------------------------------------------------- -------------------------------------------------- ---------------------------- >Tpa MxxxxSMDDSAPPSHRVCV------------------------------- -------------------------------------------------- -------------------------------------------------- ----------------------------------------------xxxx xxxGLLNYPAGCNPVEYPVxAGGSIAPxxxxxxxxxxxxxxxxx------ ---------------------LPPGSKAPPSHGLPSVAPQSKHHRSPASL PAGHTVPGPGPGPGGPPQQASSGSFAARL-----------QRESNESEPA PTRQVSPKTRGPPPLVRGSSPPPQDSQRKDRGLPHDGSRGSVSRPEDSQL YGARERAGVNVAVTEPQLLARSGFQPYRPEEARLGHPPAPPPPPTFTLDP AAAYNPYHPAAAAGLYPPHLQHAYR------------------------- -------------------------------------------------L EEQLYLERCGMLRPPLFPALPPSYHPLYGLRYSPDMLHSPLGLISPGLHE RMKLEEEHRQRETQRMREEEKEREREQEREREKERRDKSRRSPRASPSHH QEAPARKAPIAGGRERAADPRKEPSPYPPPHLIVPGSIPNPTSVTLPPPL HPINSSLEAGHAVTRLPYPSTSPHHTSPGHAIVPSHNTHTPPIMPSHNTH TPPIMPSHTTHTPSILTSHNTHTSPIISPHNPHTHASPIHSLVPHTVTSH TLHPLVPPQGNPPQLQQSSHRISNPSGRGAVKDPPPAFVRPFEDNYSQQR RSPAVAFSPVKDRTSASVSVVDQQVDSSVSSAVPKQPNNHHQHHHGAPTL EPPSPSVTRKDSIFPQTRGPAVSLSKDISARATVSENGPVKLSLCPRVSE GHTQESPLVSNDSHSHHHQPQQKLTVAVAPSYHAATLPVNSQPPSQTFPP QPYHLSSQQQQHQQPMFPFSVSSQLNHRQPSPTLINSSLPTSASQTPSEH GVANLINHQPSSTTTIPVVSSHQTTRQTTVVQAIQPVPAVVTFHQPPAVL NVPDAAKVAAVSAKEAAVPMSVWDYHYLSRSINSQRSTVGDCHSLAVSKL DLAECRRK-----NRRTNSLLNGTTASSDSDGEDSDCLVGSLWITKGPPA KLDAPPRKLRFLRMFGLTTLSRRNELELRKLERRRCPLVVAVEEAHSEGA TPSPLDLPLPRYNPDQLSRTPDYKAKVRFLRSLGLECVARRDREDHELIW QTVIAERLRRNAVSSLVEYCRKVQLCTRGDPNTRDSPDLSERPRRVRLAF GIKRPASPDTLVVPGMNGLLRPSWLLSNGVKRLAVMEEDRGGEEEGPLRW PGLEAVMEAYHRYQQERSLEHRVLQDQCECLRNQLSARRREADTLDRRLR DLVATKSTQDYERHQTQRAIDHLNASLRQL-------------------- ---RANFIVRLNMPQVRRYTNYxxTxxxxxIExASFA------------- -------------------------------------------------- -------------------------------------------------- ---------------------------- >Tbi M------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ----------------------------------------------xxx- --xGLLNYxxGCNPVEYPxxxGGSIAP----------------xxxxxxx xxxPxxxxxxxxxxxxxxxxCLPPGSKAPPSHGLPSVAPQSKHHRSPASL PAGHTVPGPGPGPGGPPQQASSGSFAARL-----------QRESNESEPA PTRQVSPKTRGPPPLVRGSSPPPQDSQRKDRGLPHDGSRGSVSRPEDSQL YGARERAGVNVAVTEPQLLARSGFQPYRPEEARLGHPPAPPPPPTFTLDP AAAYNPYHPAAAAGLYPPHLQHAYR------------------------- -------------------------------------------------L EEQLYLERCGMLRPPLFPALPPSYHPLYGLRYSPDMLHSPLGLISPGLHE RMKLEEEHRQRETQRMREEEKEREREQEREREKERRDKSRRSPRASPSHH QEAPARKAPIAGGRERAADPRKEPSPYPPPHLIVPGSIPNPTSVTLPPPL HPINSSLESGHAVTRLPYPSTSPHHTSPGHAIVPSHNTHTPPIMPSHNTH TPPIMPSHTTHTPSILTSHNTHTSPIISPHNPHTHASPIHSLVPHTVTSH TLHPLVPPQGNPPQLQQSSHRTSNPSGRGAVKDPPPAFVRPFEDNYSQQR RSPAVAFSPVKDRTSASVSVVDQQVDSSVSSAVPKQPNNHHQHHHGAPTL EPPSPSVTRKDSIFPQTRGPAVSLSKDINVRVTVSENGPVKLSLCPRVSE GHTQESPLVSNDSHSHHHQPQQKLTVAVAPSYHAAPLPVNSQPPSQTFPP QPYHLSSQQQQHQQPMFPFSVSSQLNHRQPSPTLINSSLPTSASQTPSEH GVANLINHQPSSTTTIPVVSSHQTTRQTTVVQAIQPVPAVVTFHQPPAVL NVPDAAKVAAVSAKEAAVPMSVWDYHYLSRSINSQRSTVGDCHSLAVSKL DLAECRRK-----NRRTNSLLNGTTASSDSDGEDSDCLVGSLWITKGPPA KLDAPPRKLRFLRMFGLTTLSRRNELELRKLERRRCPLVVAVEEAHSEGA TPSPLDLPLPRYNPDQLSRTPDYKAKVRFLRSLGLECVARRDREDHELIW QTVIAERLRRNAVSSLVEYCRKVQLCTRGDPNTRDSPDLSERPRRVRLAF GIKRPASPDTLVVPGMNGLLRPSWLLSNGVKRLAVMEEDRGGEEEGPLRW PGLEAVMEAYHRYQQERSLEHRVLQDQCECLRNQLSARRREADTLDRRLR DLVATKSTQDYERHQTQRAIDHLNASLRQL-------------------- ---RANFIVRLNMPQVRRYTNYxxxxxxxxIExxxxxxxxxxxxxxxxxx NEL----------------------------------------------- -------------------------RATVHxxxxxxxxxxxxxxLAETSQ xxxxxxxxxxxGTIGxxxxxxxxxxxxx >Tte M------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ----------------------------------------------xxx- --xx---------------------------------------------- ---------------------LPPGSKAPPSHGLPSVAPQSKHHRSPASL PAGHTVPGPGPGPGGPPQQASSGSFAARL-----------QRESNESEPA PTRQVSPKTRGPPPLVRGSSPPPQDSQRKDRGLPHDGSRGSVSRPEDSQL YGARERAGVNVAVTEPQLLARSGFQPYRPEEARLGHPPAPPPPPTFTLDP AAAYNPYHPAAAAGLYPPHLQHAYR------------------------- -------------------------------------------------L EEQLYLERCGMLRPPLFPALPPSYHPLYGLRYSPDMLHSPLGLISPGLHE RMKLEEEHRQRETQRMREEEKEREREQEREREKERRDKSRRSPRASPSHH QEAPARKAPIAGGRERAADPRKEPSPYTPPHLIVPGSIPNPTSVTLPPPL HPINSSLESGHAVTRLPYPSTSPHHTSPGHAIVPSHNTHTPPIMPSHNTH TPPIMPSHTTHTPSILTSHNTHTSPIISPHNPHTHASPIHSLVPHTVTSH TLHPLVPPQGNPPQLQQSSHRTSNPSGRGAVKDPPPAFVRPFEDNYSQQR RSPAVAFSPVKDRTSASVSVVDQQVDSSVSSAVPKQPNNHHQHHHGAPTL EPPSPSVTRKDSIFPQTRGPAVSLSKDINVRVTVSENGPVKLSLCPRVSE GHTQESPLVSNDSHSHHHQPQQKLTVAVAPSYHAAPLPVNSQPPSQTFPP QPYHLSSQQQQHQQPMFPFSVSSQLNHRQPSPTLINSSLPTSASQTPSEH GVANLINHQPSSTTTIPVVSSHQTTRQTTVVQAIQPVPAVVTFHQPPAVL NVPDAAKVAAVSAKEAAVPMSVWDYHYLSRSINSQRSTVGDCHSLAVSKL DLAECRRK-----NRRTNSLLNGTTASSDSDGEDSDCLVGSLWITKGPPA KLDAPPRKLRFLRMFGLTTLSRRNELELRKLERRRCPLVVAVEEAHSEGA TPSPLDLPLPRYNPDQLSRTPDYKAKVRFLRSLGLECVARRDREDHELIW QTVIAERLRRNAVSSLVEYCRKVQLCTRGDPNTRDSPDLSERPRRVRLAF GIKRPASPDTLVVPGMNGLLRPSWLLSNGVKRLAVMEEDRGGEEEGPLRW PGLEAVMEAYHRYQQERSLEHRVLQDQCECLRNQLSARRREADTLDRRLR DLVATKSTQDYERHQTQRAIDHLNASLRQL-------------------- ---RxxxxxRLNMPQVRRYTNYxxTPTxASIEWASxxYxxxxxxxxx--- -------------------------------------------------- -------------------------------GIRQCWELLQSCGLAETSQ xRPxxxxxxDKGTIGxxxxxxxxxxxxx >Tdi Mx------------------------------------------------ ----xxxxxxxxxxxLxxxxxxxxxxxxxxxxxxxxxxxxLHLFPSPxxP SSFPGDVNRTSPKPxxxQx------------------------------- -------------------------------------------------- -------------------------------------------------- ------------------AxxLPPGSKAPPSHGLPSVAPQSKHHRSPASL PAGHTVPGPGPGPGGPPQQASSGSFAARLxNLAKQAGPPxERESNESEPA PTRQVSPKTRGPPPL--------------DRGLPHDGSRGSVSRPEDSHL YGARERAGVNVAVTEPQLLARSGFQPYRPEESRLGHPPAPPPPPTFTLDP AAAYNPYHPAAAAGLYPPHLQHAYR------------------------- -------------------------------------------------L EEQLYLERCGMLRPPLFPALPPSYHPLYGLRYSPDMLHSPLGLISPGLHE RMKLEEEHRQRETQRMREEEKEREREQEREREKERRDKSRRSPRASPSHH QEAPARKAPIAGGRERAADPRKEPSPYPPPHLIVPGSIPNPTSVTLPPPL HPINSSLEAGHAVTRLPYPSTSPHHTSPGHAIVSSHNTHTPPIMPSHNTH TPPIMPSHTTHTSSILTSHNTHTSPIISPHNPHTHASPIHSMVPHTVTSH TLHPLAPPQGNPPQLQQSSHRTSNPSGRGAVKDPPPAFVRPFEDNYSQQR RSPAVAFSPVKDRTSASVSVVDQQVDSSVSSAVPKQPNTHHQHHHGAPTL EPPSPSVTRKDSIFPHTRGLAVSLSKDMSARVTVSENGPVKLSSCPRVSE GHTQESPLVSNDSHSHHHQPQQKLTVAVAPSYHAAPLSVNSQPPSQTFPP QPYHLSSQQQQHQQPMFPFSVSSQLNHRQPSPTLINSSLPTSASQPPSEH GVANLINHQPSSTTTIPVVSSHQTTRQTTVVQAIQPVPAVVTFHQPPAVL NVPDAAKVAAVSAKEVAVPMSVWDYHYLSRSINSQRSTVGDCHSLAVSKL DLAECRRK-----NRRTNSLLNGTTASSDSDGEDSDCLVGSLWITKGPPA KLDAPPRKLRFLRMFGLTTLSRRNELELRKLERRRCPLVVAVEEAHSEGA TPSPLDLPLPRYNPDQLSRTPDYKAKVRFLRSLGLECVARRDREDHELIW QTVIAERLRRNAVSSLVEYCRKVQMCTRGDPN-RDSPDRSERPRRVRLAF GIKRPASPDTLVVPGMNGLLRPSWLLSNGVKRLAVMEEDKGGEEEGPLRW PGLEAVMEAYHRYQQERSLEHRVLQDQCECLRNQLSARRREADTLDRRLR DLVATKSTQDYERHQTQRAIDHLNASLRQL-------------------- ---R---------------------------------------------- --xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxMxxxxxxxxx ---------------xxxxxxxxxxx------------------------ ---------------------------- >Tcm M------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------xxLPPGSKAPPSHGLPSVAPQSKHHRSPASL PAGHTVPGPGPGPGGPPQQASSGSFAARLxNLAKQAGPPxERESNESEPA PTRQVSPKTRGPPPLVRGSSPPPQDSQRKDRGLPHDGSRGSVSRPEDSHL YGARERAGVNVAVTEPQLLARSGFQPYRPEESRLGHPPAPPPPPTFTLDP AAAYNPYHPAAAAGLYPPHLQHAYR------------------------- -------------------------------------------------L EEQLYLERCGMLRPPLFPALPPSYHPLYGLRYSPDMLHSPLGLISPGLHE RMKLEEEHRQRETQRMREEEKEREREQEREREKERRDKSRRSPRASPSHH QEAPARKAPIAGGRERAADPRKEPSPYPPPHLIVPGSIPNPTSVTLPPPL HPINSSLEAGHAVTRLPYPSTSPHHTSPGHAIVSSHNTHTPPIMPSH-TH TPPIMPSHTTHTSSILTSHNTHTSPIISPHNPHTHASPIHSMVPHTVTSH TLHPLAPPQGNPPQLQQSSHRTSNPSGRVAVKDPPPAFVRPFEDNYSQQR RSPAVAFSPVKDRTSASVSVVDQQVDSSVSSAVPKQPNTHHQHHHGAPTL EPPSPSVTRKDSIFPHTRGLAVSLSKDLSARVTVSENGPVKLSSCPRVSE GHTQESPLVSNDSHSHHHQPQQKLTVAVAPSYHAAPLSVNSQPPSQTFPP QPYHLSSQQQQHQQPMFPFSVSSQLNHRQPSPTLINSSLPTSASQPPSEH GVANLINHQPSSTTTIPVVSSHQTTRQTTVVQAIQPVPAVVTFHQPPAVL NVPDAAKVAAVSAKEAAVPMSVWDYHYLSRSINSQRSTVGDCHSLAVSKL DLAECRRKxxxxx------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ---------------------------- >Tps Mx------------------------------------------------ ----x--------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- --------------------xLPPGSKAPPSHGLPSVAPQSKHHRSPASL PAGHTVPGPGPGPGGPPQQASSGSFAARLxNLAKQAGPPxERESNESEPA PTRQVSPKTRGPPPL--------------DRGLPHDGSRGSVSRPEDSHL YGARERAGVNVAVTEPQLLARSGFQPYRPEESRLGHPPAPPPPPTFTLDP AAAYNPYHPAAAAGLYPPHLQHAYR------------------------- -------------------------------------------------L EEQLYLERCGMLRPPLFPALPPSYHPLYGLRYSPDMLHSPLGLISPGLHE RMKLEEEHRQRETQRMREEEKEREREQEREREKERRDKSRRSPRASPSHH QEAPARKAPIAGGRERAADPRKEPSPYPPPHLIVPGSIPNPTSVTLPPPL HPINSALEAGHAVTRLPYPSTSPHHTSPGHAIVSSHNTHTPPIMPSHNTH TPPIMPSHTTHTSSILTSHNTHTSPIISPHNPHTHASPIHSMVPHTVTSH TLHPLAPPQGNPPQLQQSSHRTSNPSGRGAVKDPPPAFVRPFEDNYSQQR RSPAVAFSPVKDRTSASVSVVDQQVDSSVSSAVPKQPNTHHQHHHGAPTL EPPSPSVTRKDSIFPHTRGLAVSLSKDMSARVTVSENGPVKLSSCPRVSE GHTQESPLVSNDSHSHHHQPQQKLTVAVAPSYHAAPLSVNSQPPSQTFPP QPYHLSSQQQQHQQPMFPFSVSSQLNHRQPSPTLINSSLPTSASQPPSEH GVANLINHQPSSTTTIPVVSSHQTTRQTTVVQAIQPVPAVVTFHQPPAVL NVPDAAKVAAVSAKEVAVPMSVWDYHYLSRSINSQRSTVGDCHSLAVSKL DLAECRRK-----NRRTNSLLNGTTASSDSDGEDSDY------------- -------------------------------------------------- ---------------------------------------------HELIW QTVIAERLRRNAVSSLVEYCRKVQMCTRGDPN-RDSPDRSERPRRVRLAF GIKRPASPDTLVVPGMNGLLRPSWLLSNGVKRLAVMEEDKGGEEEGPLRW PGLEAVMEAYHRYQQERSLEHRVLQDQCECLRNQLSARRREADTLDRRLR DLVATKSTQDYERHQTQRAIDHLNASLRQLxxxxxxxxxxxxxxxxxxxx xxxx---------------------------------------------- -------------------xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx xxxxxxxxxxxxxxxx---------------------------------- ----------------------------