>Tge M-----------------HTIMA------------------------------------- ----------------AIA----------------------------------------- ------------------------------------------------------------ ---------IFIIPNSVVR----------------------------------------- ------------------------------------------------------------ -------------------------KLHWSPYRHIGLPVSPKMTTVSS----PVHPLPTV PHQAVPPSRTQDYEPWHHGASFPPSWVVTFP-TPALPPLPPPPLSGPIF----------- ----------------------------------------------PPGPSARTVRCQQV SVIQRTPPIPPPVPDKPASVSSDEEDAVEEAVLMQEPEQEAPIDYHVPKKRPSTEERRET EDARERELRRCNSLKIVSRRPPLSLILGRQLTGGKPRVAAAGHGHTGRSGGGGPSGGGHQ SAGGGHNSSMNYSGGGGGGVSSGGGGGMLGGSTGGSGGSMNPGGGGRGTNYGPNSPPTGS LPPFYESLK-GGGGGLGIGGGAGGHPFNPGNGYGLLPAGLSMDCDTGQDSGMGYAGGGTA AAHHKQYSMLQNMCASYGLVTVKEDIDDDLSEYTSKLCDTRDPLPPVHLLGGSANNLLAN NYLGNNPYDVSDSMMVDLVSGGAVDPLQFTATLTFSSPSDHNALLESLSDDLFLQRMSSD DDLGDNNNNSVEADHALLNDGLSSSPRLQQEQNIPPPVEPSVDPFPEHCQNGVGGLTRSF DTSRNYAAPTHFNKSALFMSGGGGSHQEPYHSLPKERQELALHICSSSPAPSEESQLQVQ VQMHHHQNNHNHHQQPLLSPGLSFSGSGLDLDSPTTMSLPSPGGASCSLDENGSMSPPGS ISGRRDSSDISNISSLQVRVNILQQRLGLPGDVALEFVNGGHGIKNPLANHDIGPGHQRS HRSSGDVEKLPPMPAVSAGPDDPSRFSCRVCSKSFSLQRLLNRHMKCHSDVKRYLCTFCG KGFNDTFDLKRHTRTHTGVRPYKCNLCEKSFTQRCSLESHCLKVHGVQHQYAYKERRTKD LTVVQRVDEITANVCNKEKVAVPANENDYSPCEITMYVCEECGHTTNEPEVHYLHLKENH PYSPALLKFYDKRHFKFTNSNFANMLLQVRS- >Tms ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------MAD------------------------------ ---------------------------------------------KEAA----------- ---------------------------HAHVLSNARPPLAESDRLKTSYYVIGDRSC--- --GHRPPNKPQDDD---RLFPRPPTPDSSSPGSPTKPDTGPRALAPRRFISSILGGDVPY SGSTTPSPAPIARPHIPTRAERKEYLPIPPPPPAPSSSPPTPPPLPPPTPTP-AVRFQQV SVIQRTPPIPPPVPDKPALVSSDEDDAVEEAVLMQEPEQEAPIDYHVPKKRPSTEERRET EDARERELRRCNSLKIVSRRPPLSLILGRQLTGGKPRVAAAGHGHTGRSGGGGPSGGGHQ SAGGGHNSSMNYSGGGGGGVSSGGGGGMLGGSTGGGGGSMNPGGGGRGTNYGPNSPPTGS LPPFYESLKGGGGGGLGVGGGAGGHPFNPGNGYGLLPAGLSMDCDTGQDSGMGYAGGGTA AAHHKQYSMLQNMCASYGLVTVKEDIDDDLSEYTSKLCDTRDPLPPVHLLGGSANNLLAN NYLGNNPYDVSDSMMVDLVSGGAVDPLQFTATLTFSSPSDHNALLESLSDDLFLQRMSSD DDLGDNNNNSVETDHALLNDGLSSSPRLQQEQNIPPPVEPSVDPFPEHCQNGVGGLTRSF DTSRNYAAPTHFNKSALFMSGGGGNHQEPYHSLPKERQELALHICSSSPAPSEESQLQVQ VQMHHHQNNHNHHQQPLLSPGLSFSGSGLDLDSPTTMSLPSPGGASCSLDENGSMSPPGS ISGRRDSSDISNISSLQVRVNILQQRLGLPGDVALEFVNGGHGIKNPLANHDIGPGHQRS HRSSGDVEKLPPMPAVSAGPDDPSRFSCRVCSKSFSLQRLLNRHMKCHSDVKRYLCTFCG KGFNDTFDLKRHTRTHTGVRPYKCNLCEKSFTQRCSLESHCLKVHGVQHQYAYKERRTK- -----------------------------------MYVCEECGHTTNEPEVHYLHLKENH PYSPALLKFYDKRHFKFTNSNFANMLLQVRS- >Tpa ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --MHHHQNNHNHHQQPLLSPGLSFSGSGLDLDSPTTMSLPSPGGASCSLDENGSMSPPGS ISGRRDSSDISNISSLQVRVNILQQRLGLPGDVALEFVNGGHGIKNPLANHDIGPGHQRS HRSSGDVEKLPPMPAVSAGPDDPSRFSCRVCSKSFSLQRLLNRHMKCHSDVKRYLCTFCG KGFNDTFDLKRHTRTHTGVRPYKCNLCEKSFTQRCSLESHCLKVHGVQHQYAYKERRTK- -----------------------------------MYVCEECGHTTNEPEVHYLHLKENH PYSPALLKFYDKRHFKFTNSNFANMLLQVRS- >Tte ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------MVDLCVPILFLL--------------------- ------------------------------------------------------------ -------------------------------------------------------CV--- --EDRPPSKPQDDD---RLFPRPPTPDSSSPGSPTKPDTGPRALAPRRFISSILGGDVPY SGSTTPSPAPTVRPHIPTRAERKEYLPIPPPPPAPPSTPPTPPPLPPPTPAP-ALRCQQV SVIQRTPLIPPPVPDKPASVSSDEDDAVEEA----------------------------- ------------------------------------------------------------ SAGGGHNSSMNYSGGGGGGVSSGGGGGMLGGSTGGSGGSMNPGGGGRGTNYGPNSPPTGS LPPFYESLK-GGGGGLGIGGGAGGHPFNPGNGYGLLPAGLSMDCDTGQDSGMGYAGGGTA AAHHKQYSMLQNMCASYGLVTVKEDIDDDLSEYTSKLCDTRDPLPPVHLLGGPANNLLAN NYLGNNPYDVSDSMMVDLVSGGAVDPLQFTATLTFSSPSDHNALLESLSDDLFLQRMSSD DDLGDNNNNSVETDHALLNDGLSSSPRLQQEQNIPPPVEPSVDPFPEHCQNGVGGLTRSF DTSRNYAAPTHFNKSALFMSGGGGSHQEPYHSLPKERQELALHICSSSPAPSEESQLQVQ VQMHHHQNNHNHHQQPLLSPGLSFSGSGLDLDSPTTMSLPSPGGASCSLDENGSMSPPGS ISGRRDSSDISNISSLQVRVNILQQRLGLPGDVALEFVNGGHGIKNPLANHDIGPGHQRS HRSSGDVEKLPPMPAVSAGPDDPSRFSCRVCSKSFSLQRLLNRHMKCHSDVKRYLCTFCG KGFNDTFDLKRHTRTHTGVRPYKCNLCEKSFTQRCSLESHCLKVHGVQHQYAYKERRTK- -----------------------------------MYVCEECGHTTNEPEVHYLHLKENH PYSPALLKFYDKRHFKFTNSNFANMLLQVRS- >Tce ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------MVDLCVPILFLL--------------------- ------------------------------------------------------------ -------------------------------------------------------CV--- --EDRPPNKPQDDD---RLFPRPPTPDSSSPGSPTKPDTGPRALAPRRFISSILGGDVPY SGSTTPSPAPIARPHIPTRAERKEYLPIPPPPPAPPSSPPTPPPLPPPTPTP-AVRCQQV SVIQRTPPIPPPVPDKPALVSSDEDDAVEEAVLMQEPEQEAPIDYHVPKKRPSTEERRET EDARERELRRCNSLKIVSRRPPLSLILGRQLTGGKPRVAAAGHGHTGRSGGGGPSGGGHQ SAGGGHNSSMNYSGGGGGGVSSGGGGGMLGGSTGGGGGSMNPGGGGRGTNYGPNSPPTGS LPPFYESLKSGGGGGLGVGGGAGGHPFNPGNGYGLLPAGLSMDCDTGQDSGMGYAGGGTA AAHHKQYSMLQNMCASYGLVTVKEDIDDDLSEYTSKLCDTRDPLPPVHLLGGSANNLLAN NYLGNNPYDVSDSMMVDLVSGGAVDPLQFTATLTFSSPSDHNALLESLSDDLFLQRMSSD DDLGDNNNNSVETDHALLNDGLSSSPRLQQEQNIPPPVEPSVDPFPEHCQNGVGGLTRSF DTSRNYAAPTHFNKSALFMSGGGGNHQEPYHSLPKERQELALHICSSSPAPSEESQLQVQ VQMHHHQNNHNHHQQPLLSPGLSFSGSGLDLDSPTTMSLPSPGGASCSLDENGSMSPPGS ISGRRDSSDISNISSLQVRVNILQQRLGLPGDVALEFVNGGHGIKNPLANHDIGPGHQRS HRSSGDMEKLPPMPAVSAGPDDPSRFSCRVCSKSFSLQRLLNRHMKCHSDVKRYLCTFCG KGFNDTFDLKRHTRTHTGVRPYKCNLCEKSFTQRCSLESHCLKVHGVQHQYAYKERRTK- -----------------------------------MYVCEECGHTTNEPEVHYLHLKENH PYSPALLKFYDKRHFKFTNSNFANMLLQVRS- >Tsi M----------------------------------------------------------- ------------------------------------------------------------ -------------------------------------------------G---------- --GEGRVSVVFVIFGTEVHLVRVNISKMVDLCVPILFLLCVEVIGKVENWLKKTWKSRVN SYRERTIPIIVIAGQLNRPIHAERIQARLYLERPQQTKNIQSARDKPSAPEIAHNSHQLT HPRDTFIILRLMGHLQNARHHGGRCHLHYSQFSRAQTPLEPVSPCLNS----PSKKL--- --KDRPPSKPQDDD---RLFPRPPTPDSSSPGSPTKPDTGPRALAPRRFISSILGGDVPY SGSTTPSPAPIARPHILTRAERKEYLPIPPPPTAPPSSPPTPPPLPPPTPTP-AVRCQQV SVIQRTPPIPPPVPDKPTSVSSDEDDAVEEAVLMQEPEQEAPIDYHVPKKRPSTEERRET EDARERELRRCNSLKIVSRRPPLSLILGRQLTGGKPRVAAAGHGHTGRSGGGGPSGGGHQ SAGGGHNSSMNYSGGGGGGVSSGGGGGMLGGSTGGGGGSMNPGGGGRGTNYGPNSPPTGS LPPFYESLKGGGGGGLGVGGGAGGHPFNPGNGYGLLPAGLSMDCDTGQDSGMGYAGGGTA AAHHKQYSMLQNMCASYGLVTVKEDIDDDLSEYTSKLCDTRDPLPPVHLLGGSANNLLAN NYLGNNPYDVNDSMMVDLVSGGAVDPLQFTATLTFSSPSDHNALLESLSDDLFLQRMSSD DDLGDNNNNSVETDHALLNDGLSSSPRLQQEQNIPPPVEPSVDPFPEHCQNGVGGLTRSF DTSRNYAAPTHFNKSALFMSGGGGSHQEPYHSLPKERQELALHICSSSPAPSEESQLQVQ VQMHHHQNNHNHHQQPLLSPGLSFSGSGLDLDSPTTMSLPSPGGASCSLDENGSMSPPGS ISGRRDSSDISNISSLQVRVNILQQRLGLPGDVALEFVNGGHGIKNPLANHDIGPGHQRS HRSSGDVEKLPPMPAVSSGPDDPSRFSCRVCSKSFSLQRLLNRHMKCHSDVKRYLCTFCG KGFNDTFDLKRHTRTHTGVRPYKCNLCEKSFTQRCSLESHCLKVHGVQHQYAYKERRTK- -----------------------------------MYVCEECGHTTNEPEVHYLHLKENH PYSPALLKFYDKRHFKFTNSNFANMLLQVRS- >Tcm M----------------------------------------------------------- ------------------------------------------------------------ -------------------------------------------------GEKFFDCLCLS WKGEGRVSVVFVIFGTEVHLVRVNISKMVDLCVPILFLLCVEVIGKVENWLKKTWKSRVN SYRERTIPIIVIAGQLNRPIHAERIQARLYLERPQQTKNIQSARDKPSAPEIAHNSHQLT HPRDTFIILRLMGHLQNARHHGGRCHLHYSQFSRAQTPLEPVSPCLNS----PSKKL--- --KDRPPSKPQDDD---RLFPRPPTPDSSSPGSPTKPDTGPRALAPRRFISSILGGDVPY SGSTTPSPAPIARPHIPTRAERKEYLPIPPPPPAPPSSPPTPPPLPPPTPTP-AVRCQQV SVIQRTPPIPPPVPDKPTSVSSDEDDAVEEAVLMQEPEQEAPIDYHVPKKRPSTEERRET EDARERELRRCNSLKIVSRRPPLSLILGRQLTGGKPRVAAAGHGHTGRSGGGGPSGGGHQ SAGGGHNSSMNYSGGGGGGVSSGGGGGMLGGSTGGGGGSMNPGGGGRGTNYGPNSPPTGS LPPFYESLKGGGGGGLGVGGGAGGHPFNPGNGYGLLPAGLSMDCDTGQDSGMGYAGGGTA AAHHKQYSMLQNMCASYGLVTVKEDIDDDLSEYTSKLCDTRDPLPPVHLLGGSANNLLAN NYLGNNPYDVNDSMMVDLVSGGAVDPLQFTATLTFSSPSDHNALLESLSDDLFLQRMSSD DDLGDNNNNSVETDHALLNDGLSSSPRLQQEQNIPPPVEPSVDPFPEHCQNGVGGLTRSF DTSRNYAAPTHFNKSALFMSGGGGSHQEPYHSLPKERQELALHICSSSPAPSEESQLQVQ VQMHHHQNNHNHHQQPLLSPGLSFSGSGLDLDSPTTMSLPSPGGASCSLDENGSMSPPGS ISGRRDSSDISNISSLQVRVNILQQRLGLPGDVALEFVNGGHGIKNPLANHDIGPGHQRS HRSSGDVEKLPPMPAVSSGPDDPSRFSCRVCSKSFSLQRLLNRHMKCHSDVKRYLCTFCG KGFNDTFDLKRHTRTHTGVRPYKCNLCEKSFTQRCSLESHCLKVHGVQHQYAYKERRTK- -----------------------------------MYVCEECGHTTNEPEVHYLHLKENH PYSPALLKFYDKRHFKFTNSNFANMLLQNNDM >Tbi MRHTLLYPGKQGCFGGLVHTEMAESHVATAMCDRESPNHLKRNYASRQLEKPPPVHPTEI RTSISPSSAVELNTTSALANYATEAGLNLIDSLCKATPRSQGQEAVVSKLEGVTRRSGGG KRTLIEKFHHLHHQHPPTSVLPHPVAGKASDNNKVKVVGQPQRIVGFSLGERVQVFLNPS NDVSIEGQIVFVIFGTKVHLVRVNISKMVDLCVPILFLLCVE------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---DRPPSKPQDDD---RLFPRPPTPDSSSPGSPTKPDTGPRALAPRRFISSILGGDVPY SGSTTPSPAPIVRPHIPTRAERKE------------------------------------ -----TPLIPPPVPDKPASVSSDEDDAVEEAVLMQEPEQEAPIDYHVPKKRPSTEERRET EDARERELRRCNSLKIVSRRPPLSLILGRQLTGGKPRVAAAGHGHTGRSGGGGPSGGGHQ SAGGGHNSSMNYSGGGGGGVSSGGGGGMLGGSTGGSGGSMNPGGGGRGTNYGPNSPPTGS LPPFYESLK-GGGGGLGIGGGAGGHPFNPGNGYGLLPAGLSMDCDTGQDSGMGYAGGGTA AAHHKQYSMLQNMCASYGLVTVKEDIDDDLSEYTSKLCDTRDPLPPVHLLGGSANNLLAN NYLGNNPYDVSDSMMVDLVSGGAVDPLQFTATLTFSSPSDHNALLESLSDDLFLQRMSSD DDLGDNNNNSVETDHALLNDGLSSSPRLQQEQNIPPPVEPSVDPFPEHCQNGVGGLTRSF DTSRNYAAPTHFNKSALFMSGGGGSHQEPYHSLPKERQELALHICSSSPAPSEESQLQVQ VQMHHHQNNHNHHQQPLLSPGLSFSGSGLDLDSPTTMSLPSPGGASCSLDENGSMSPPGS ISGRRDSSDISNISSLQVRVNILQQRLGLPGDVALEFVNGGHGIKNPLANHDIGPGHQRS HRSSGDVEKLPPMPAVSAGPDDPSRFSCRVCSKSFSLQRLLNRHMKCHSDVKRYLCTFCG KGFNDTFDLKRHTRTHTGVRPYKCNLCEKSFTQRCSLESHCLKVHGVQHQYAYKERRTK- -----------------------------------MYVCEECGHTTNEPEVHYLHLKENH PYSPALLKFYDKRHFKFTNSNFANMLLQVRS- >Tps ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------MVDLCVPILFLLCVE------------------ ----------------------ERIQGRLYLERPQQTKNSQSARDKPSAPEIAHNSHQLT HPRDTFIILRLMGHLQNARHHGGRCHLHYSQFSRAQTPLEPVSPCLNS----PSKKL--- --KDRPPSKPQDDD---RLFPRPPTPDSSSPGSPTKPDTGPRALAPRRFISSILGGD--- ------------------------------------------------------------ -------------------------------------------------KRPSTEERRET EDARERELRRCNSLKIVSRRPPLSLILGRQLTGGKPRVAAAGHGHTGRSGGGGPSGGGHQ SAGGGHNSSMNYSGGGGGGVSSGGGGGMLGGSTGGGGGSMNPGGGGRGTNYGPNSPPTGS LPPFYESLKGGGGGGLGVGGGAGGHPFNPGNGYGLLPAGLSMDCDTGQDSGMGYAGGGTA AAHHKQYSMLQNMCASYGLVTVKEDIDDDLSEYTSKLCDTRDPLPPVHLLGGSANNLLAN NYLGNNPYDVNDSMMVDLVSGGAVDPLQFTATLTFSSPSDHNALLESLSDDLFLQRMSSD DDLGDNNNNNVETDHALLNDGLSSSPRLQQEQNIPPPVEPSVDPFPEHCQNGVGGLTRSF DTSRNYAAPTHFNKSALFMSGGGGSHQEPYHSLPKERQELALHICSSSPAPSEESQLQVQ VQMHHHQNNHNHHQQPLLSPGLSFSGSGLDLDSPTTMSLPSPGGASCSLDENGSMSPPGS ISGRRDSSDISNISSLQVRVNILQQRLGLPGDVALEFVNGGHGIKNPLANHDIGPGHQRS HRSSGDVEKLPPMPVVSSGPDDPSRFSCRVCSKSFSLQRLLNRHMKCHSDVKRYLCTFCG KGFNDTFDLKRHTRTHTGVRPYKCNLCEKSFTQRCSLESHCLKVHGVQHQYAYKERRTK- -----------------------------------MYVCEECGHTTNEPEVHYLHLKENH PYSPALLKFYDKRHFKFTNSNFANMLLQVRS- >Tdi M-----------------HAIMA------------------------------------- ----------------AVA----------------------------------------- ------------------------------------------------------------ ---------IFIIPNSVVR----------------------------------------- ------------------------------------------------------------ -------------------------RLHWSPYRHIGPPVSPKMTTVSS----PVHPLPTV PHQAVPPSQTQDHEPWHRGASFPPSWVVTFP-TPALPLLPPPPLPDPIF----------- ------------------------------------------------------------ ------------------------------------------------------------ --------------------PP------------------------------GPS----- -----------------------------------ARSSMNPGGGGRGTNYGPNSPPTGS LPPFYESLKGGGGGGLGVGGGAGGHPFNPGNGYGLLPAGLSMDCDTGQDSGMGYAGGGTA AAHHKQYSMLQNMCASYGLVTVKEDIDDDLSEYTSKLCDTRDPLPPVHLLGGSANNLLAN NYLGNNPYDVNDSMMVDLVSGGAVDPLQFTATLTFSSPSDHNALLESLSDDLFLQRMSSD DDLGDNNNNSVETDHTLLNDGLSSSPRLQQEQNIPPPVEPSVDPFPEHCQNGVGGLTRSF DTSRNYAAPTHFNKSALFMSGGGGSHQEPYHSLPKERQELALHICSSSPAPSEESQLQVQ VQMHHHQNNHNHHQQPLLSPGLSFSGSGLDLDSPTTMSLPSPGGASCSLDENGSMSPPGS ISGRRDSSDISNISSLQVRVNILQQRLGLPGDVALEFVNGGHGIKNPLANHDIGPGHQRS HRSSGDVEKLPPMPAVSAGPDDPSRFSCRVCSKSFSLQRLLNRHMKCHSDVKRYLCTFCG KGFNDTFDLKRHTRTHTGVRPYKCNLCEKSFTQRCSLESHCLKVHGVQHQYAYKERRTK- -----------------------------------MYVCEECGHTTNEPEVHYLHLKENH PYSPALLKFYDKRHFKFTNSNFANMLLQVRS-