>Tge x------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- --------------------------xxxxxxxxxxxxxxxxxxxxxxxx xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx------------------- -------------------------------------------------- -------------------------------------------------- -----------------VRCQQVSVIQRTPPIPPPVPDKPASVSSDEEDA VEEAVLMQEPEQEAPIDYHVPKKRPSTEERRETEDARERELRRCNSLKIV SRRPPLSLILGRQLTGGKPRVAAAGHGHTGRSGGGGPSGGGHQSAGGGHN SSMNYSGGGGGGVSSGGGGGMLGGSTGGSGGSMNPGGGGRGTNYGPNSPP TGSLPPFYESLK-GGGGGLGIGGGAGGHPFNPGNGYGLLPAGLSMDCDTG QDSGMGYAGGGTAAAHHKQYSMLQNMCASYGLVTVKEDIDDDLSEYTSKL CDTRDPLPPVHLLGGSANNLLANNYLGNNPYDVSDSMMVDLVSGGAVDPL QFTATLTFSSPSDHNALLESLSDDLFLQRMSSDDDLGDNNNNSVEADHAL LNDGLSSSPRLQQEQNIPPPVEPSVDPFPEHCQNGVGGLTRSFDTSRNYA APTHFNKSALFMSGGGGSHQEPYHSLPKERQELALHICSSSPAPSEESQL QVQVQMHHHQNNHNHHQQPLLSPGLSFSGSGLDLDSPTTMSLPSPGGASC SLDENGSMSPPGSISGRRDSSDISNISSLQVRVNILQQRLGLPGDVALEF VNGGHGIKNPLANHDIGPGHQRSHRSSGDVEKLPPMPAVSAGPDDPSRFS CRVCSKSFSLQRLLNRHMKCHSDVKRYLCTFCGKGFNDTFDLKRHTRTHT GVRPYKCNLCEKSFTQRCSLESHCLKVHGVQHQYAYKERRTKDLTVVQRV DEITANVCNKEKVAVPANENDYSPCEIxMYVCEECGHTTNEPEVHYLHLK ENHPYSPALLKFYDKRHFKFTNSNFANMLLQ----VRS >Tdi x------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- --------------------------xxxxxxxxxxxxxxxxxxxxxxxx xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------SMNPGGGGRGTNYGPNSPP TGSLPPFYESLKGGGGGGLGVGGGAGGHPFNPGNGYGLLPAGLSMDCDTG QDSGMGYAGGGTAAAHHKQYSMLQNMCASYGLVTVKEDIDDDLSEYTSKL CDTRDPLPPVHLLGGSANNLLANNYLGNNPYDVNDSMMVDLVSGGAVDPL QFTATLTFSSPSDHNALLESLSDDLFLQRMSSDDDLGDNNNNSVETDHTL LNDGLSSSPRLQQEQNIPPPVEPSVDPFPEHCQNGVGGLTRSFDTSRNYA APTHFNKSALFMSGGGGSHQEPYHSLPKERQELALHICSSSPAPSEESQL QVQVQMHHHQNNHNHHQQPLLSPGLSFSGSGLDLDSPTTMSLPSPGGASC SLDENGSMSPPGSISGRRDSSDISNISSLQVRVNILQQRLGLPGDVALEF VNGGHGIKNPLANHDIGPGHQRSHRSSGDVEKLPPMPAVSAGPDDPSRFS CRVCSKSFSLQRLLNRHMKCHSDVKRYLCTFCGKGFNDTFDLKRHTRTHT GVRPYKCNLCEKSFTQRCSLESHCLKVHGVQHQYAYKERRTK-------- ----------------------------MYVCEECGHTTNEPEVHYLHLK ENHPYSPALLKFYDKRHFKFTNSNFANMLLQ----VRS >Tms -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ------------------------Mx------------------------ -------------------------------------------------- -------------------------------------------------- ---------------------xxxxxx----------------------- -------------------------------------------------- ------------------------------xxxxxxxxxxxxxxxxxxxx xxxxxxxxxxxRPPNKPQDDDRLFPRPPTPDSSSPGSPTKPDTGPRALAP RRFISSILGGDVPYSGSTTPSPAPIARPHIPTRAERKExxxIPPPPPAPS SSPPTPPPLPPPTPTPAVRFQQVSVIQRTPPIPPPVPDKPALVSSDEDDA VEEAVLMQEPEQEAPIDYHVPKKRPSTEERRETEDARERELRRCNSLKIV SRRPPLSLILGRQLTGGKPRVAAAGHGHTGRSGGGGPSGGGHQSAGGGHN SSMNYSGGGGGGVSSGGGGGMLGGSTGGGGGSMNPGGGGRGTNYGPNSPP TGSLPPFYESLKGGGGGGLGVGGGAGGHPFNPGNGYGLLPAGLSMDCDTG QDSGMGYAGGGTAAAHHKQYSMLQNMCASYGLVTVKEDIDDDLSEYTSKL CDTRDPLPPVHLLGGSANNLLANNYLGNNPYDVSDSMMVDLVSGGAVDPL QFTATLTFSSPSDHNALLESLSDDLFLQRMSSDDDLGDNNNNSVETDHAL LNDGLSSSPRLQQEQNIPPPVEPSVDPFPEHCQNGVGGLTRSFDTSRNYA APTHFNKSALFMSGGGGNHQEPYHSLPKERQELALHICSSSPAPSEESQL QVQVQMHHHQNNHNHHQQPLLSPGLSFSGSGLDLDSPTTMSLPSPGGASC SLDENGSMSPPGSISGRRDSSDISNISSLQVRVNILQQRLGLPGDVALEF VNGGHGIKNPLANHDIGPGHQRSHRSSGDVEKLPPMPAVSAGPDDPSRFS CRVCSKSFSLQRLLNRHMKCHSDVKRYLCTFCGKGFNDTFDLKRHTRTHT GVRPYKCNLCEKSFTQRCSLESHCLKVHGVQHQYAYKERRTK-------- ----------------------------MYVCEECGHTTNEPEVHYLHLK ENHPYSPALLKFYDKRHFKFTNSNFANMLLQ----VRS >Tpa -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -----MHHHQNNHNHHQQPLLSPGLSFSGSGLDLDSPTTMSLPSPGGASC SLDENGSMSPPGSISGRRDSSDISNISSLQVRVNILQQRLGLPGDVALEF VNGGHGIKNPLANHDIGPGHQRSHRSSGDVEKLPPMPAVSAGPDDPSRFS CRVCSKSFSLQRLLNRHMKCHSDVKRYLCTFCGKGFNDTFDLKRHTRTHT GVRPYKCNLCEKSFTQRCSLESHCLKVHGVQHQYAYKERRTK-------- ----------------------------MYVCEECGHTTNEPEVHYLHLK ENHPYSPALLKFYDKRHFKFTNSNFANMLLQ----VRS >Tte -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ------------------------MVDLCVPILFxxxxx----------- -------------------------------------------------- -------------------------------------------------- ---------------------D---------------------------- -------------------------------------------------- -------------------------------------------------- -----------RPPSKPQDDDRLFPRPPTPDSSSPGSPTKPDTGPRALAP RRFISSILGGDVPYSGSTTPSPAPTVRPHIPTRAERKExxxIPPPPPAPP STPPTPPPLPPPTPAPALRCQQVSVIQRTPLIPPPVPDKPASVSSDEDDA VEEA---------------------------------------------- -------------------------------------------SAGGGHN SSMNYSGGGGGGVSSGGGGGMLGGSTGGSGGSMNPGGGGRGTNYGPNSPP TGSLPPFYESLK-GGGGGLGIGGGAGGHPFNPGNGYGLLPAGLSMDCDTG QDSGMGYAGGGTAAAHHKQYSMLQNMCASYGLVTVKEDIDDDLSEYTSKL CDTRDPLPPVHLLGGPANNLLANNYLGNNPYDVSDSMMVDLVSGGAVDPL QFTATLTFSSPSDHNALLESLSDDLFLQRMSSDDDLGDNNNNSVETDHAL LNDGLSSSPRLQQEQNIPPPVEPSVDPFPEHCQNGVGGLTRSFDTSRNYA APTHFNKSALFMSGGGGSHQEPYHSLPKERQELALHICSSSPAPSEESQL QVQVQMHHHQNNHNHHQQPLLSPGLSFSGSGLDLDSPTTMSLPSPGGASC SLDENGSMSPPGSISGRRDSSDISNISSLQVRVNILQQRLGLPGDVALEF VNGGHGIKNPLANHDIGPGHQRSHRSSGDVEKLPPMPAVSAGPDDPSRFS CRVCSKSFSLQRLLNRHMKCHSDVKRYLCTFCGKGFNDTFDLKRHTRTHT GVRPYKCNLCEKSFTQRCSLESHCLKVHGVQHQYAYKERRTK-------- ----------------------------MYVCEECGHTTNEPEVHYLHLK ENHPYSPALLKFYDKRHFKFTNSNFANMLLQ----VRS >Tce -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ------------------------MVDLCVPILFxxxxx----------- -------------------------------------------------- -------------------------------------------------- ---------------------D---------------------------- -------------------------------------------------- -------------------------------------------------- -----------RPPNKPQDDDRLFPRPPTPDSSSPGSPTKPDTGPRALAP RRFISSILGGDVPYSGSTTPSPAPIARPHIPTRAERKExxxIPPPPPAPP SSPPTPPPLPPPTPTPAVRCQQVSVIQRTPPIPPPVPDKPALVSSDEDDA VEEAVLMQEPEQEAPIDYHVPKKRPSTEERRETEDARERELRRCNSLKIV SRRPPLSLILGRQLTGGKPRVAAAGHGHTGRSGGGGPSGGGHQSAGGGHN SSMNYSGGGGGGVSSGGGGGMLGGSTGGGGGSMNPGGGGRGTNYGPNSPP TGSLPPFYESLKSGGGGGLGVGGGAGGHPFNPGNGYGLLPAGLSMDCDTG QDSGMGYAGGGTAAAHHKQYSMLQNMCASYGLVTVKEDIDDDLSEYTSKL CDTRDPLPPVHLLGGSANNLLANNYLGNNPYDVSDSMMVDLVSGGAVDPL QFTATLTFSSPSDHNALLESLSDDLFLQRMSSDDDLGDNNNNSVETDHAL LNDGLSSSPRLQQEQNIPPPVEPSVDPFPEHCQNGVGGLTRSFDTSRNYA APTHFNKSALFMSGGGGNHQEPYHSLPKERQELALHICSSSPAPSEESQL QVQVQMHHHQNNHNHHQQPLLSPGLSFSGSGLDLDSPTTMSLPSPGGASC SLDENGSMSPPGSISGRRDSSDISNISSLQVRVNILQQRLGLPGDVALEF VNGGHGIKNPLANHDIGPGHQRSHRSSGDMEKLPPMPAVSAGPDDPSRFS CRVCSKSFSLQRLLNRHMKCHSDVKRYLCTFCGKGFNDTFDLKRHTRTHT GVRPYKCNLCEKSFTQRCSLESHCLKVHGVQHQYAYKERRTK-------- ----------------------------MYVCEECGHTTNEPEVHYLHLK ENHPYSPALLKFYDKRHFKFTNSNFANMLLQ----VRS >Tsi x------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ------------------------------------x------------x EGxxxVVxxxxxxxxxxxRVNISKMVDLCVPILFLLCVxVIGKVENWLKK TWKSRVNSYRERTIPIIVIAGQLNRPIHAERIQARLYLERPQQTKNIQSA RDKPSAPEIAHNSHQLTHPRDTFIILRLMGHLQNARHHGGRxxxHYSQxx xxxxxxxxxxxxxxxxxxxxxD---------------------------- -------------------------------------------------- -------------------------------------------------- -----------RPPSKPQDDDRLFPRPPTPDSSSPGSPTKPDTGPRALAP RRFISSILGGDVPYSGSTTPSPAPIARPHILTRAERKEYxxIPPPPTAPP SSPPTPPPLPPPTPTPAVRCQQVSVIQRTPPIPPPVPDKPTSVSSDEDDA VEEAVLMQEPEQEAPIDYHVPKKRPSTEERRETEDARERELRRCNSLKIV SRRPPLSLILGRQLTGGKPRVAAAGHGHTGRSGGGGPSGGGHQSAGGGHN SSMNYSGGGGGGVSSGGGGGMLGGSTGGGGGSMNPGGGGRGTNYGPNSPP TGSLPPFYESLKGGGGGGLGVGGGAGGHPFNPGNGYGLLPAGLSMDCDTG QDSGMGYAGGGTAAAHHKQYSMLQNMCASYGLVTVKEDIDDDLSEYTSKL CDTRDPLPPVHLLGGSANNLLANNYLGNNPYDVNDSMMVDLVSGGAVDPL QFTATLTFSSPSDHNALLESLSDDLFLQRMSSDDDLGDNNNNSVETDHAL LNDGLSSSPRLQQEQNIPPPVEPSVDPFPEHCQNGVGGLTRSFDTSRNYA APTHFNKSALFMSGGGGSHQEPYHSLPKERQELALHICSSSPAPSEESQL QVQVQMHHHQNNHNHHQQPLLSPGLSFSGSGLDLDSPTTMSLPSPGGASC SLDENGSMSPPGSISGRRDSSDISNISSLQVRVNILQQRLGLPGDVALEF VNGGHGIKNPLANHDIGPGHQRSHRSSGDVEKLPPMPAVSSGPDDPSRFS CRVCSKSFSLQRLLNRHMKCHSDVKRYLCTFCGKGFNDTFDLKRHTRTHT GVRPYKCNLCEKSFTQRCSLESHCLKVHGVQHQYAYKERRTK-------- ----------------------------MYVCEECGHTTNEPEVHYLHLK ENHPYSPALLKFYDKRHFKFTNSNFANMLLQ----VRS >Tcm x------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ------------------------------------xxxxFDCLCLSxxx ExxxxVVxxxxxxxxxxxRVNISKMVDLCVPILFLLCVEVIGKVENWLKK TWKSRVNSYRERTIPIIVIAGQLNRPIHAERIQARLYLERPQQTKNIQSA RDKPSAPEIAHNSHQLTHPRDTFIILRLMGHLQNARHHGxxxxxHYSQxx xxxxxxxxxxxxxxxxxxxxxD---------------------------- -------------------------------------------------- -------------------------------------------------- -----------RPPSKPQDDDRLFPRPPTPDSSSPGSPTKPDTGPRALAP RRFISSILGGDVPYSGSTTPSPAPIARPHIPTRAERKExxxIPPPPPAPP SSPPTPPPLPPPTPTPAVRCQQVSVIQRTPPIPPPVPDKPTSVSSDEDDA VEEAVLMQEPEQEAPIDYHVPKKRPSTEERRETEDARERELRRCNSLKIV SRRPPLSLILGRQLTGGKPRVAAAGHGHTGRSGGGGPSGGGHQSAGGGHN SSMNYSGGGGGGVSSGGGGGMLGGSTGGGGGSMNPGGGGRGTNYGPNSPP TGSLPPFYESLKGGGGGGLGVGGGAGGHPFNPGNGYGLLPAGLSMDCDTG QDSGMGYAGGGTAAAHHKQYSMLQNMCASYGLVTVKEDIDDDLSEYTSKL CDTRDPLPPVHLLGGSANNLLANNYLGNNPYDVNDSMMVDLVSGGAVDPL QFTATLTFSSPSDHNALLESLSDDLFLQRMSSDDDLGDNNNNSVETDHAL LNDGLSSSPRLQQEQNIPPPVEPSVDPFPEHCQNGVGGLTRSFDTSRNYA APTHFNKSALFMSGGGGSHQEPYHSLPKERQELALHICSSSPAPSEESQL QVQVQMHHHQNNHNHHQQPLLSPGLSFSGSGLDLDSPTTMSLPSPGGASC SLDENGSMSPPGSISGRRDSSDISNISSLQVRVNILQQRLGLPGDVALEF VNGGHGIKNPLANHDIGPGHQRSHRSSGDVEKLPPMPAVSSGPDDPSRFS CRVCSKSFSLQRLLNRHMKCHSDVKRYLCTFCGKGFNDTFDLKRHTRTHT GVRPYKCNLCEKSFTQRCSLESHCLKVHGVQHQYAYKERRTK-------- ----------------------------MYVCEECGHTTNEPEVHYLHLK ENHPYSPALLKFYDKRHFKFTNSNFANMLLQxxxM--- >Tps -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ------------------------MVDLCVPILFLLCVx----------- -----------------------------ERIQGRLYLERPQQTKNSQSA RDKPSAPEIAHNSHQLTHPRDTFIILRLMGHLQNARHHGGRxxxHYSQxx xxxxxxxxxxxxxxxxxxxxxD---------------------------- -------------------------------------------------- -------------------------------------------------- -----------RPPSKPQDDDRLFPRPPTPDSSSPGSPTKPDTGPRALAP RRFISSILGGD--------------------------------------- -------------------------------------------------- ----------------------KRPSTEERRETEDARERELRRCNSLKIV SRRPPLSLILGRQLTGGKPRVAAAGHGHTGRSGGGGPSGGGHQSAGGGHN SSMNYSGGGGGGVSSGGGGGMLGGSTGGGGGSMNPGGGGRGTNYGPNSPP TGSLPPFYESLKGGGGGGLGVGGGAGGHPFNPGNGYGLLPAGLSMDCDTG QDSGMGYAGGGTAAAHHKQYSMLQNMCASYGLVTVKEDIDDDLSEYTSKL CDTRDPLPPVHLLGGSANNLLANNYLGNNPYDVNDSMMVDLVSGGAVDPL QFTATLTFSSPSDHNALLESLSDDLFLQRMSSDDDLGDNNNNNVETDHAL LNDGLSSSPRLQQEQNIPPPVEPSVDPFPEHCQNGVGGLTRSFDTSRNYA APTHFNKSALFMSGGGGSHQEPYHSLPKERQELALHICSSSPAPSEESQL QVQVQMHHHQNNHNHHQQPLLSPGLSFSGSGLDLDSPTTMSLPSPGGASC SLDENGSMSPPGSISGRRDSSDISNISSLQVRVNILQQRLGLPGDVALEF VNGGHGIKNPLANHDIGPGHQRSHRSSGDVEKLPPMPVVSSGPDDPSRFS CRVCSKSFSLQRLLNRHMKCHSDVKRYLCTFCGKGFNDTFDLKRHTRTHT GVRPYKCNLCEKSFTQRCSLESHCLKVHGVQHQYAYKERRTK-------- ----------------------------MYVCEECGHTTNEPEVHYLHLK ENHPYSPALLKFYDKRHFKFTNSNFANMLLQ----VRS >Tbi xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxRESPNHLKRNYASRQLE KPPPVHPTEIRTSISPSSAVELNTTSALANYATExxxxLIDSxxxxxPxx xxxxxxVSKLEGxxxxxxxxxxxxxxxxxxxxxxHPPxxxxxxxxxxxxx xxxxVKxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx------------ -----IxxxxxxxxxxxxxVNISKMVDLCVPILFLLCxE----------- -------------------------------------------------- -------------------------------------------------- ---------------------D---------------------------- -------------------------------------------------- -------------------------------------------------- -----------RPPSKPQDDDRLFPRPPTPDSSSPGSPTKPDTGPRALAP RRFISSILGGDVPYSGSTTPSPAPIVRPHIPTRAERKE------------ ----------------------------TPLIPPPVPDKPASVSSDEDDA VEEAVLMQEPEQEAPIDYHVPKKRPSTEERRETEDARERELRRCNSLKIV SRRPPLSLILGRQLTGGKPRVAAAGHGHTGRSGGGGPSGGGHQSAGGGHN SSMNYSGGGGGGVSSGGGGGMLGGSTGGSGGSMNPGGGGRGTNYGPNSPP TGSLPPFYESLK-xGGGGLGIGGGAGGHPFNPGNGYGLLPAGLSMDCDTG QDSGMGYAGGGTAAAHHKQYSMLQNMCASYGLVTVKEDIDDDLSEYTSKL CDTRDPLPPVHLLGGSANNLLANNYLGNNPYDVSDSMMVDLVSGGAVDPL QFTATLTFSSPSDHNALLESLSDDLFLQRMSSDDDLGDNNNNSVETDHAL LNDGLSSSPRLQQEQNIPPPVEPSVDPFPEHCQNGVGGLTRSFDTSRNYA APTHFNKSALFMSGGGGSHQEPYHSLPKERQELALHICSSSPAPSEESQL QVQVQMHHHQNNHNHHQQPLLSPGLSFSGSGLDLDSPTTMSLPSPGGASC SLDENGSMSPPGSISGRRDSSDISNISSLQVRVNILQQRLGLPGDVALEF VNGGHGIKNPLANHDIGPGHQRSHRSSGDVEKLPPMPAVSAGPDDPSRFS CRVCSKSFSLQRLLNRHMKCHSDVKRYLCTFCGKGFNDTFDLKRHTRTHT GVRPYKCNLCEKSFTQRCSLESHCLKVHGVQHQYAYKERRTK-------- ----------------------------MYVCEECGHTTNEPEVHYLHLK ENHPYSPALLKFYDKRHFKFTNSNFANMLLQ----VRS