>Tge M------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------GKFPGKPSKTLNRKRVKVENCPVSQ ENDSLKAAENIYLRLAVFNEIFGNDKQAGRQFNGFTSQEIELAISLVKKT YSKDLDVDCKLNENKNVRLWDSFSKELQNLPSDSKFRPNVSKSEKTNNSE ETDDESFDVGGKKNGIxTSKIPLKSSLHSDTSRSIQSSSKDTSKSSD-SI VCDDESCDSDELTEYDPSKKSLDPSLWSCSSGGKVILRKARLKLKSPVAK SIVDGPFSATTSRPSS---------------------------------- -------------------------------------------------- ---ASSSTPGTVICGVCGAVRFYRFVKQARKFKILCCESCRKFISKIMRR QMEAMPPVGCQRGDGKCTVPPILRSQQWRATNKKISCAYKARCPACWLKM CLQAFKMPENLHKKLTRMLPSYMRKPPFIYIKQEKTSTASAQEESAEITG SSPNHFIKLEPFHDEEMNDKRHKRKAALDSFIKITPNRQVEEKKKKKRVD AIGSHKQKRLTHIRTSKILKKAAKNLSKSKEDKFSSRSLKKKAKEKNKKV NGSKVRKKAGSLSGVLDDSRR----------------------------- -------------------------QCQELKGPRVKHVCRSASIVLGQSQ ATFPPKIIEKKPVKSVQRSVKVPKKNKGHSNHMIDKxxAKHETERIQNNH IKSEANTLGMESSQPVYEIASISSGVSTRETSPLPVARSKVVKQPAPVLP PL------------------------xxxxxxxxLPPSSSFIPxxxxxYS PFFSSCPHSLxxxxFLPPCSLMWPSAPILxxxDNLSLLNLxxxPxxxxxx xxxxxxxxxxxxxxxxxxLNLQVERITINLNLRLERYTLTCVLVL----- ------------------VRTLPISNISNVPEPQLQICI----------- -------------------------------------------------- --------------------DFWESYDPEEVSNTGFALIGSEPFSVRALC FLCGSAGHExxIHCxxxxEPYHPFCVEDGYCRSSLANCADEWRCDWVCRR CTMCHSCGQGLGQQVSCQRCHKIYHIECLGTDRITSRVHSPDRPWxCSAC LRCKSCGKADVTVFVGNLPLCNGCFKLRQKDRRLVSESGPKRIQIPVPQS NRTLEQGSRRFQNWKLPLKHSHVSINSTRLRQHTEMMECGQCKSWVHAKC EGLSDEKYQVLSYLPESVEFVCRLCCTLPPAPWWFAVEEELKAGFL---- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ---------------DHPHSxxVxxxDPGIxxxKDSSSDITETDGSVKNQ RQQFLLKDYAACVKNVYTKPVISSPISIQVEDQLSGLSPDSTFSDVYLKS PNKTLMVSMATPPSDSGIGSTDDELKLSTEEETEEVKDGLAEIDFISNVE CALPTKLTPTKQLEPVVVPDKSPLGLDASKTEGFAASRDCYCAEASSGKL TPTLLRIRKKISSNEYSSLLQFHQEMEHIINVTHHLDLVKTYHNALIEVF PWFDPKLAKVSSKNTGKSILIASPSKSGEHPSDKPLLEDSQENLCREVSK FNPPKGDLKYYYSDHIVEDMRTCMFCKGLGDGLPTREGRLLYCGQNGWTH ANCALWSAEVFEEIDGSLQNVHSAISRGRMIRCRLCGKKGASVGCCTRNC AETYHFYCALKNKCALMDDKTVFCPSHRKDASGKRLTEGSDFDLARPIYV ELDRKKKKYVEPNIVRFMIGSLIVENLGEFVARVSDNSEAIIPMEFCCTR LYWSSLEPWRIVRYNMKITMRTCKPQESQDLGKNITVDHTKEKNVVDQVL REISQWHHDLNNSKDQSDDVKVNCDLFISPSKKNNSCQTDTLNVKAKRNF KFTEERKVAREVLDHILDSVCREVDDSLTDPQNSADLLPPELKDAIFEDL PHDLLDGISMQDIFPKLMNVEEVSTAETCFATESLKEGKELGEEALLSSD IEAISVISNNQDISLKNIRSEAAIELASQTDLWFESNDCKDETSLLEDEC FITNIPKEYLHIGTTKDIKRSKSDGIPQQIRRKLSCGSLSQHRSCSLTWS CKLDGPHKRRKGSRLAGRGSEDDSSRLITTAEGAGDKAHRLQELRMPSIA STVAEGVRELKYCFEDDATSSEGAAGVRRRPTLPKEEGKENKCMSWNDRL LQKLPQLDGAIDSSSSSEEGSPPRDNYVSEFTPHRTLLYAPSVIEANEEE PVRCDRCHRTYRTRTSFERHLPTCSSDFILSTSESDSENARSSEEEGVKY QPTTISSSKSVFSPQKNVISSGQSCIIEESPTQLLNQPSECLNNVKPVFD SNIIPTTKSQTKQKPIPKPILINGRQRGRAVNKQKLSAIRQQNHSSMMNH SLSPHSQQVHPIIHCQPQSNPQQQSPTVIMQQMASPNMMAAYIDAFQQQT GQSLQYIATVDAHNNGYNKAQFITAAPNTLLSGTYQLPEGFVGLQNGGIS VIPSMQLAATPSTVLGTLIQPQPTLQCGVVSADQMVLGSTGGMFLTAQPM YYGLETIVSNTVMQSSQFVSASVPGVMAASSSFSTTTQVFQASKLEPIID VPSGFVIVNPHAPLADTTLGSxxxxxxxxxxxxxxxSPSVTV--xxxxSL PxP----xALPPPPPPQVHIPISQxPPPLPTPRPSVPLIQPNVQTSQAPW RYNYNSPQNVYMASPKDNDNYTSSASQHLRATFPVEKCSCRKSETLNFKP PVTLPIYVSSPHTASTTRTQSSITEQKSVSSASVQTSAPVTLARQPV-TP IQRQTRLIPELSPQSKKIPEKTNKVN------------------------ -------------------------------------------------- --GMQGFSIKSLKMKPLVCVSHEISKKEVTTIPVPKTQDSANN-ESKESP PNRSNGITPHQNVKIIVPLKDKKLPNDYLPNVTYEIHSQDGFVCKSSSIT EVWQKVFEAVQEARKAHKMPPLPRNPFDGTVNGLQMLGLKHNGLRYLVEQ LPGAARCFKYKPRFHKQPPIGVDKESRPCENLSGCARAERFKTRSPYDMF GWLASRHRKPPKLLTPTDNDSAISNRRATSTNLPMAMRFRYLKETSKEAV GVYRSHIHGRGLFCLRNIELGEMVIEYAGEVIRSTLTDKREKYYESKDIG CYMFRIDDHLVVDATMRGNAARFINHSCE--------------------- -------------------------------------------------- -----------------------------------------------xxx xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx xxxxxxxxxxxxxxxxxxxxxxxxxxxxxNYATEAG-------------- --------P----------------------------------------- --------------- >Tms -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -----------------------------------MMECGQCKSWVHAKC EGLSDEKYQVLSYLPESVEFVCRLCCTLPPAPWWFAVEEELKAGFLGVLK AISKNRKACALLKWSPKKKCMCKSPIFSKTIDSQERSEHSDSSLEDLNSV NL------------------------------------------------ -------------------------------------------------- -------------------------------------------------- ---------------DHPHSFEVEGIDQGIIFSKDSSSDITETDGSVKNQ RQPFLLKDYAARVKNIYTKPVISSPISIQVEDQLSGLSPDSTLSDVCLKS PNKTLMVSMATPPSDSGIGSTDDELKLSTEEETEEGKDGLAEIDFISNVE CALPTKLTPTEQLDPVVVPDKSLLVLDANKTEGFAASRDCYCAEASSGKL TPTLLRIRKKISSNEYSSLLQFHQEMEHIINVTHHLDLVNTYHNALIEVF PWFDPKLAKVSSKNTGKSILIASPSKSGEHPSDKSRLEDSQENLCREVSK FNPPKGDLKYYYSDHIVEDMRTCMFCKGLGDGLPTREGRLLYCGQNGWTH ANCALWSAEVFEEIDGSLQNVHSAISRGRMIRCRLCGKKGASVGCCTRNC AETYHFNCALKNKCALMDDKTVFCPSHRKDAAGKRLTEGSDFDLARPIYV ELDRKKKKYVEPNIVRFMIGSLIVENLGEFVARVSDNSEAIIPMEFCCTR LYWSSLEPWRIVRYNMKITMRTCKPQESQDLGKNITVDHSKDKNVVDKVL REISQWHHYLSSSKDQSDDVKVNCDLFISPLKKNNSCQTDTLNVKAKRNF KFVEERKVAREVLGHILDNVCREVDDNLADPQNSADLLPPELKDAIFEDL PHDLLDGISMQDIFPKLMNVEEVSTVDTCFGTESLKEGKELGEEALLSSD IEAISVISNNQD-SLKNIRSEAAMELASQTDSWFESNDCKDETSLLEDEC FITNIPKEYLHIGTTKDLKRSKSDGIPQQIRRKPSCGSISQHRSCSLTWS CKLDGPHKRRKGSRVAGRGSEDDSSRLITTAEGAGDKAHRLQELRMPSIA STVAEGVRELKYCFEDDATSSEGAAGVRRRPILPKEEGKENKCMPWNDRL LQKLPQLDGAIDSSSSSEEGSPPRDNYVNEFTPHRTLLYAPSVIEANEEE PVRCDRCHRTYRTRTSFERHLPTCSSDFILSTSESDSENARSSEEEGVKY QPITTSSSKSVFSPQKNVISSGQSCIIEQSPTQLINKPSECLNTVKPVFD SNIIPITKSQTKQKPIPKPILINGRQRGRAVNKQKLSAIRQQNHSNMINQ SLSPHSQQVHPIIHCQPQSNPQQQSPTVIMQQMASPNMMAAYIDAFQQQT GQSLQYIATVDAHNNGYNKAQFITAAPNTLLSGTYQLPEGFVGLQNGGIS VIPSMQLAATPSTVLGTIIQPQPTLQC----------------------- -------------------------------------------------- -------------------xSSxxITCxxxxVTMNVSPSVTV-xxxxxxx xxx----PAPPPPPSPQVNIPISQ-PPPLPTPRLSVPLTQPNVQTSQAPW -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- --------------------SHEISKKEVTTLPVPIIQDNTNN-ESKESP PNRSNGITPHQNVKIIVPLKDKKLPNDYLPNVTYEIHSQDGFVCKSSSIT EVWQKVFEAVQEARKAHKMPPLPRNPFDGTVNGLQMLGLKHNGLRYLVEQ LPGAARCFKYKPRFHKQQPVGVDKESQPRENLSGCARAERFKSRSPYDMF GWLASRHRKPPKLLTPTDNDSAISNRRATSTNLPMAMRFRYLKETSKEAV GVYRSHIHGRGLFCLRNIELGEMVIEYAGEVIRSTLTDKREKYYESKDIG CYMFRIDDHLVVDATMRGNAARFINHSCE--------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- --------PNCYSRVVDILGMKHILIFALRRIHQGEELTYDYKFPFEDDK IPCTCGSRKCRKYLN >Tce -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -----------------------------------MMECGQCKSWVHAKC EGLSDEKYQVLSYLPESVEFVCRLCCTLPPAPWWFAVEEELKAGFLGVLK AISKNRKACALLKWSPKKKCMCKSPIFSKTIDSQERSEHSDSSLEDLNSV NL------------------------------------------------ -------------------------------------------------- -------------------------------------------------- ---------------DHPHSFEVEGIDQGIIFSKDSSSDIIETDGSVKNQ RQPFLLKDYAARVKNIYTKPVISSPISIQVEDQLSGLSPDSTLSDVCLKS PNKTLMVSMATPPSDSGIGSTDDELKLSTEEETEEGKDGLAEIDFISNVE CALPTKLTPTEQLNPVVVPDKSLLVLDANKTEGFAASRDCYCAEASSGKL TPTLLRIRKKISSNEYSSLLQFHQEMEHIINVTHHLDLVNTYHNALIEVF PWFDPKLAKVSSKNTGKSILIASPSKSGEHPSDKSRLEDSQENLCREVSK FNPPKGDLKYYYSDHIVEDMRTCMFCKGLGDGLPTREGRLLYCGQNGWTH ANCALWSAEVFEEIDGSLQNVHSAISRGRMIRCRLCGKKGASVGCCTRNC AETYHFNCALKNKCALMDDKTVFCPSHRKDAAGKRLTEGSDFDLARPIYV ELDRKKKKYVEPNIVRFMIGSLIVENLGEFVARVSDNSEAIIPMEFCCTR LYWSSLEPWRIVRYNMKITMRTCKPQESQDLGKNITVDHSKDKNVVDKVL REISQWHHDLSSSKDQSDDVKVNCDLFISPLKKNNSCQTDTLNVKAKRNF KFVEERKVAREVLGHILDNVCREVDDNLADPQNSADLLPPELKDAIFEDL PHDLLDGISMQDIFPKLMNAEEVSTVDTCFGTESLKEGKELGEEALLSSD IEAISVISNNQD-SLKNIRSEAAMELASQTDPWFESNDCKDETSLLEDEC FITNIPKEYLHIGTTKDLKRSKSDGIPQQIRRKPSCGSISQHRSCSLTWS CKLDGPHKRRKGSRLAGRGSEDDSSRLITTAEGAGDKAHRLQELRMPSIA STVAEGVRELKYCFEDDATSSEGAAGVRRRPILPKEEGKENKCMPWNDRL LQKLPQLDGAIDSSSSSEEGSPPRDNYVSEFTPHRTLLYAPSVIEANEEE PVRCDRCHRTYRTRTSFERHLPTCSSDFILSTSESDSENARSSEEEGVKY QPITTSSSKSVFSPQKNVISSGQSCIIEQSPTQLINKPSECLNTVKPVFD SNIIPITKSQTKQKPIPKPILINGRQRGRAVNKQKLSAIRQQNHSNMINQ SLSPHSQQVHPIIHCQPQSNPQQQSPTVIMQQMASPNMMAAYIDAFQQQT GQSLQYIATVDAHNNGYNKAQFITAAPNTLLSGTYQLPEGFVGLQNGGIS VIPSMQLAATPSTVLGTIIQPQPTLQCGVVSADQMVLGSTGGMFLTAQPM YYGLETIVSNTVMQSSQFVSASVPGVMAASSSFSTTTQVFQASKLEPIMD VPSGFVIVNPHAPLADTTLGSSxxITCxxxxVTMNxSPSVTVxxxxxxPL PxP----PAPxPPPSPQVNIPISQ-PPPLPTPRLSVPLTQPNVQTSQAPW RYSYNSPQNVYMASPKDNDYYTSSASQHLRATFPVEKCSCRKSETLNIKP PVTLPIYVSSPHTASPTRTQSSITEQKSVSSASVQTSAPVTLARQPV-TP IQRQTRLIPELSPQSKKIPEKTNKIN------------------------ -------------------------------------------------- --GMQGFSLKSLKMKPLVCVSHEISKKEVTTLPVPIIQDNTNN-ESKESP PNRSNGITPHQNVKIIVPLKDKKLPNDYLPNVTYEIHSQDGFVCKSSSIT EVWQKVFEAVQEARKAHKMPPLPRNPFDGTVNGLQMLGLKHNGLRYLVEQ LPGAARCFKYKPRFHKQQPVGVDKESQPRENLSGCARAERFKSRSPYDMF GWLASRHRKPPKLLTPTDNDSAISNRRATSTNLPMAMRFRYLKETSKEAV GVYRSHIHGRGLFCLRNIELGEMVIEYAGEVIRSTLTDKREKYYESKDIG CYMFRIDDHLVVDATMRGNAARFINHSCE--------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- --------PNCYSRVVDILGMKHILIFALRRIHQGEELTYDYKFPFEDDK IPCTCGSRKCRKYLx >Tps -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ------------------VRTLPISTISNVPKPQLQICI----------- -------------------------------------------------- --------------------DFWESYDPEEVSNTGFALIGSEPFSVRAMC FLCGSAGQExxIHCxxxxEPYHPFCVEDGYCRSSLANCADEWRCDWVCRR CTMCHSCGRGLGQQVSCQRCHKIYHIECLGTDRITSRVHSPDRPW----- -------------------------------------------------- -----------------------------------MMECGQCKSWVHAKC EGLSDEKYQVLSYLPESVEFVCRLCCTLPPAPWWFAVEEELKAGFLGVLK AISKNRKACALLKWSPKKKCMCKSPIFSKAIDSQERSEHSDSSLEDLNSV NLGNQEVIAAKSLKKSLFVGSEEIKKSCNLTPQIKVGQEEQSxxTxxxDN STxxxEEKSSSTKCFDDLINK----------------------------- -------------------------------------------------- -------------------------------------------------- -----------------------------VEDQLSGLSPDSTLSDVCLKS PNKTLMVSMATPPSDSGIGSTDDELKLSTEEETEEGKDGLAEINFISNVE CALSTKLTPTEQLEPVVVPDKSLLVLDANKTEGFAASRDCYCAEASSGKL TPTLLRIRKKISSNEYSSLLQFHQEMEHIINVTHHLDLVNTYHNALIEVF PWFDPKLAKVSSKNTGKSILIASPSKSGEHPSDKSRLEDSQENLCREVSK FNPPKGDLKYYYSDHIVEDMRTCMFCKGLGDGLPTREGRLLYCGQNGWTH ANCALWSAEVFEEIDGSLQNVHSAISRGRMIRCRLCGKKGASVGCCTRNC AETYHFNCALKNKCALMDDKTVFCPSHRKDAAGKRLTEGSDFDLARPIYV ELDRKKKKYVEPNIVRFMIGSLIVENLGEFVARVSDNSEAIIPMEFCCTR LYWSSLEPWRIVRYNMKITMRTCKPQESQDLGKNITVDHTKDKNVVDKVL REISQWHHDLSSSKDQSDDVKVNCDLFISPLKKNNSCQTDTLNVKAKRNF KFAEEKKVAREVLGHILDNICKEVDDNLADPQNSADLLPPELKDAIFEDL PHDLLDGISMQDIFPKLMNVEEVSTVETCFGTESLKEGKELGEEALLSSD IEAISVISNNQD-SLKNIRSEAAMEFASQTDPWFESNDCKDETSLLEDEC FITNIPKEYLHIGTTKDLKRSKSDGIPQQIRRKLSCGSISQHRSCSLTWS CKLDGPHKRRKGSRLAGRGSEDDLSRLITTAEGAGDKAHRLQELRMPSIA STVAEGVRELKYCFEDDATSSEGAAGVRRRPILPKEEGKENKCMPWNDRL LQKLPQLDGAIDSSSSSEEGSPPRDNYVSEFTPHRTLLYAPSVIEANEEE PVRCDRCHRTYRTRTSFERHLPTCSSDFILSTSESDSENARSSEEEGVKY QPITTSSSKSVFSPQKNVISSGQACIIEQSPTQMINKPSECLNTVKPVFD SNIIPITKSQTKQKPIPKPILINGRQRGRAVNKQKISAIRQQNHSSMINQ SLSPHSQQVHPIIHCQPQSNHQQQSPTVIMQQMASPNMMAAYIDAFQQQT GQSLQYIATVDAHNNGYNKAQFITAAPNTLLSGTYQLPEGFVGLQNGGIS VIPSMQLAATPSTVLGTIIQPQPTLQCGVVSADQMVLGSTGGMFLTAQPM YYGLETIVSNTVMQSSQFVSASVPGVMAASSSFSTTTQVFQASKLEPIMD VPSGFVIVNPHAPLADTTLGSSxxITCxxxxVTMNVSPSVTV--xxPPPL PPP----xAxPPPPSPQVNIPISQ-PPPLPTPRISVPLTQPNVQTSQAPW RYSYNSPQNVYMASPKDNDHYTSSASQHLRATFPVEKCSCRKSETLNVKP PVTLPIYVSSPHTASPTRTQSSITEQKSVSSASVQTSAPVTLARQPVxTP IQRQTRLIPELSPQSKKIPEKTNKIN------------------------ -------------------------------------------------- --GMQGFSLKSLKMKPLVCVSHEISKKEVTTLPVPITQDNTNNxTSKESP PNRSNGITPQQNVKIIVPLKDKKLPNDYLPNVTYEIHSQDGFVCKSSSIT EVWQKVFEAVQEARKAHKMPPLPRNPFDGTVNGLQMLGLKHNGLRYLVEQ LPGAARCFKYKPRFHKQQPVGVDKESQPRENLSGCARAERFKTRSPYDMF GWLASRHRKPPKLLTPTDNDSAISNRRATSTNLPMAMRFRYLKETSKEAV GVYRSHIHGRGLFCLRNIELGEMVIEYAGEVIRSTLTDKREKYYESKDIG CYMFRIDDHLVVDATMRGNAARFINHSCE--------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- --------PNCYSRVVDILGMKHILIFALRRIHQGEELTYDYKFPFEDDK IPCTCGSRKCRKYLN >Tdi xx---------------------------------xPKEISLEHEILLHP xYxxxxxxxxxxxKLYTEVEGTCTxxxGFVIAVTTIDNIGAGIIQxxQGF VVYPVKYKAIVxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxED DKPxxxxxxxxxxxxxxFDNTVEAHVPSPDGLGxxxxxxxxxDDxxxxxx xxxxxxxxxxxxxxxxxxxxxxxxxx------------------------ -----------------------------RQFNGFTSQEIESAISIVKKT YNKDLAVDCKSNENKNVRYWDSFSQELQNLPSDSKSRPNVSKSEKTNNSE ETDDQSFDVEGKKNGIxTSKIPLKSSLHSDTSRSIQSSSKDTTKSTDSSI VCDDESCDSDALTEYDPSKKPLDPSLWSCSSGGKVILRKARLKLKSPVAK SIVDGPFSATTSRPSS---------------------------------- -------------------------------------------------- ---ASSSTPGTVICGVCGAVRFYRFVKQARKFKILCCESCRKFISKIMRR QTEAMPPLGCQRGDGKCTVPPILRSQQWRATNKKISSGYKARCPACWLKM CLQAFQMPENLHKKLTRMLPSFMRKPPFTYIKQEKTSTASAQEEPGETTG SSPNHFIKSEPFHDEEMNDKRHKRKAALDSFIKITPNRQVEEKKKKKTVD AIGSHKQKRLTHIRTSKILKKAAKNLSKSKEDKFSSRSLKKKAKEKNKKM NGSKVRKKASSLSGVLDDSRR----------------------------- -------------------------QCQELKGPRVKHVCRSASIVLGQSQ ATFPPKIMEKKPVKSVQRPIKVPKKNKSHSNHVADKxxAKHETERTQNNH IKSEAHTLGMEASQPVCEIASISSCVSTRETSPLPVARSKVVKQPAPILP PMVxxxx-----------xx------------------------------ -------------------------------------------------- ------------------LNLQVERITLNLNLQ----------------- ------------------VRTLPISTISNVPKPQLQICI----------- -------------------------------------------------- --------------------DFWESYDPEEVSNTGFALIGSEPFSVRAMC FLCGSAGQExxIHCxxxxEPYHPFCVEDGYCRSSLANCADEWRCDWVCRR CTMCHSCGRGLGQQVSCQRCHKIYHIECLGTDRITSRVHSPDRPW----- -------------------------------------------------- -----------------------------------MMECGQCKSWVHAKC EGLSDEKYQVLSYLPESVEFVCRLCCTLPPAPWWFAVEEELKAGFLGVLK AISKNRKACALLKWSPKKKCMCKSPIFSKAIDSQERSEHSDSSLEDLNSV NLGNQEVIAAKSLKKSLFVGSEEIKKSCNLTPQIKVGQEEQSxxTxxxDN STxxxEEKSSSTKCFDDLINK----------------------------- -------------------------------------------------- -------------------------------------------------- -----------------------------VEDQLSGLSPDSTLSDVCLKS PNKTLMVSMATPPSDSGIGSTDDELKLSTEEETEEGKDGLAEINFISNVE CALSTKLTPTEQLEPVVVPDKSLLVLDANKTEGFAASRDCYCAEASSGKL TPTLLRIRKKISSNEYSSLLQFHQEMEHIINVTHHLDLVNTYHNALIEVF PWFDPKLAKVSSKNTGKSILIASPSKSGEHPSDKSRLEDSQENLCREVSK FNPPKGDLKYYYSDHIVEDMRTCMFCKGLGDGLPTREGRLLYCGQNGWTH ANCALWSAEVFEEIDGSLQNVHSAISRGRMIRCRLCGKKGASVGCCTRNC AETYHFNCALKNKCALMDDKTVFCPSHRKDAAGKRLTEGSDFDLARPIYV ELDRKKKKYVEPNIVRFMIGSLIVENLGEFVARVSDNSEAIIPMEFCCTR LYWSSLEPWRIVRYNMKITMRTCKPQESQDLGKNITVDHTKDKNVVDKVL REISQWHHDLSSSKDQSDDVKVNCDLFISPLKKNNSCQTDTLNVKAKRNF KFAEEKKVAREVLGHILDNICKEVDDNLADPQNSADLLPPELKDAIFEDL PHDLLDGISMQDIFPKLMNVEEVSTVETCFGTESLKEGKELGEEALLSSD IEAISVISNNQD-SLKNIRSEAAMEFASQTDPWFESNDCKDETSLLEDEC FITNIPKEYLHIGTTKDLKRSKSDGIPQQIRRKLSCGSISQHRSCSLTWS CKLDGPHKRRKGSRLAGRGSEDDLSRLITTAEGAGDKAHRLQELRMPSIA STVAEGVRELKYCFEDDATSSEGAAGVRRRPILPKEEGKENKCMPWNDRL LQKLPQLDGAIDSSSSSEEGSPPRDNYVSEFTPHRTLLYAPSVIEANEEE PVRCDRCHRTYRTRTSFERHLPTCSSDFILSTSESDSENARSSEEEGVKY QPITTSSSKSVFSPQKNVISSGQACIIEQSPTQMINKPSECLNTVKPVFD SNIIPITKSQTKQKPIPKPILINGRQRGRAVNKQKISAIRQQNHSSMINQ SLSPHSQQVHPIIHCQPQSNHQQQSPTVIMQQMASPNMMAAYIDAFQQQT GQSLQYIATVDAHNNGYNKAQFITAAPNTLLSGTYQLPEGFVGLQNGGIS VIPSMQLAATPSTVLGTIIQPQPTLQCGVVSADQMVLGSTGGMFLTAQPM YYGLETIVSNTVMQSSQFVSASVPGVMAASSSFSTTTQVFQASKLEPIMD VPSGFVIVNPHAPLADTTLGSSxxITCxxxxVTMNVSPSVTV--xxPPPL PPP----xAxPPPPSPQVNIPISQ-PPPLPTPRISVPLTQPNVQTSQAPW RYSYNSPQNVYMASPKDNDHYTSSASQHLRATFPVEKCSCRKSETLNVKP PVTLPIYVSSPHTASPTRTQSSITEQKSVSSASVQTSAPVTLARQPVxTP IQRQTRLIPELSPQSKKIPEKTNKIN------------------------ -------------------------------------------------- --GMQGFSLKSLKMKPLVCVSHEISKKEVTTLPVPITQDNTNNxTSKESP PNRSNGITPHQNVKIIVPLKDKKLPNDYLPNVTYEIHSQDGFVCKSSSIT EVWQKVFEAVQEARKAHKMPPLPRNPFDGTVNGLQMLGLKHNGLRYLVEQ LPGAARCFKYKPRFHKQQPVGVDKESQPRENLSGCARAERFKTRSPYDMF GWLASRHRKPPKLLTPTDNDSAISNRRATSTNLPMAMRFRYLKETSKEAV GVYRSHIHGRGLFCLRNIELGEMVIEYAGEVIRSTLTDKREKYYESKDIG CYMFRIDDHLVVDATMRGNAARFINHSCE--------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- --------PNCYSRVVDILGMKHILIFALRRIHQGEELTYDYKFPFEDDK IPCTCGSRKCRKYLN >Tcm M------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------GKFPGKPSKTLNRKRVKVENCPVSQ ENDSLKAAENIYLRLAVFNEIFGNDKQVGRQFNGFTSQEIDSAISLVNKT YNKDLAVDCKSNENKNVRYWDSFSQELQNLPSDSKSRLNVSKSEKTNNSE ETDDQSFDVEGKKNGI---------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ---ASSSTPGTVICGVCGAVRFYRFVKQARKFKILCCESCRKFISKIMRR QTEAMPPLGCQRGDGKCTVPPILRSQQWRATNKKISCGYKARCPACWLKM CLQAFQMPENLHKKLTRMLPSFMRKPPFTYIKQEKTSTASAQEEPGETTG SSPNHFIKLEPFHDEEMNDKRHKRKAALDSFIKITPNRQVEEKKKNKRVD AIGSHKQKRLTHIRTSKILKKAAKNLSKSKEDKFSSRSLKKKAKEKNKKM NGSKVRKKASSLSGVLDDSRR----------------------------- -------------------------QCQELKGPRVKHVCRSASIVLGQSQ ATFPPKIMEKKPVKSVQRSIKVPKKNKSHSNHVADKxxAKHETERNQNSH IKSEVHTLGMEASQPVCEIASISSCVSTRETSPLPVARSKVVKQPAPILP PMVxxxx-----------xx------------------------------ -------------------------------------------------- ------------------LNLQIERITLNLNLQLER--------xxxxxx xxxxxLRDKHIPQKVSKxVRTLPISTISNVPKPQLQICI----------- -------------------------------------------------- --------------------DFWESYDPEEVSNTGFALIGSEPFSVRAMC FLCGSAGQExxIHCxxxxEPYHPFCVEDGYCRSSLANCADEWRCDWVCRR CTMCHSCGQGLGQQVSCQRCHKIYHIECLGTDRITSRVHSPDRPW----- -------------------------------------------------- -----------------------------------MMECGQCKSWVHAKC EGLSDEKYQVLSYLPESVEFVCRLCCTLPPAPWWLAVEEELKAGFLGVLK AISKNRKACALLKWSPKKKCMCKSPIFSKTIDSQERSEHSDSSLEDLNSV NLSNQEVxAAKSLKKxxxxxSEEIKKSCNLTPQIKLxQEEQSxxTxxxDN ATxxxEEKSSSTKCFDDLIxx----------------------------- -------------------------------------------------- ---------------DHPHSFEVEGIDQAIICSKDSSRDITETDGSVKNQ RQPFLLKDYAARVKNIYTKPVISSPISIQVEDQLSGLSPDSTLSDVCLKS PNKTLMVSMATPPSDSGIGSTDDELKLSTEEETEEGKDGLAEIDFISNVE CALSTKLTPTEQLEPVVVPDKSLLVLDANKTEGFAASRDCYCAEASSGKL TPTLLRIRKKISSNEYSSLLQFHQEMEHIINVTHHLDLVNTYHNALIEVF PWFDPKLAKVSSKNTGKSILIASPSKSGEHPSDKSRLEDSQENLCREVSK FNPPKGDLKYYYSDHIVEDMRTCMFCKGLGDGLPTREGRLLYCGQNGWTH ANCALWSAEVFEEIDGSLQNVHSAISRGRMIRCRLCGKKGASVGCCTRNC AETYHFNCAIKNKCALMDDKTVFCPSHRKDAAGKRLTEGSDFDLARPIYV ELDRKKKKYVEPNIVRFMIGSLIVENLGEFVARVSDNSEAIIPMEFCCTR LYWSSLEPWRIVRYNMKITMRACKPQESQDLGKNITVDHTKDKNVVDQVL REISQWHHDLSSSKDQPDDVKVNCDLFISPLKKNNSCQTDTLNVKAKRNF KFAEEKKVAREVLGHILDNICKEVDDNLADPQNSADLLPPELKDAIFEDL PHDLLDGISMQDIFPKLMNVEEVSTVETCFGTESLKEGKELSEEALLSSD IEAISVISNNQD-SLKNIRSEAAMEFASQTDPWFETNDCKDETSLLEDEC FITNIPKEYLHIGTTKDLKRSKSDGIPQQIRRKLSCGSISQHRSCSLTWS CKLDGPHKRRKGSRLAGRGSEDDSSRLITTAEGAGDKAHRLQELRMPSIA STVAEGVRELKYCFEDDATSSEGAAGVRRRPILPKEEGKENKCMPWNDRL LQKLPQLDGAIDSSSSSEEGSPPRDNYVSEFTPHRTLLYAPSVIEANEEE PVRCDRCHRTYRTRTSFERHLPTCSSDFILSTSESDSENARSSEEEGAKY QPITTSSSKSVFSPQKNVISSGQACIIEQSPTRMINKPSECLNTVKPVFD SNIIPITKSQTKQKPIPKPILINGRQRGRAVNKQKISAIRQQNHSSMINQ SLSPHSQQVHPIIHCQPQSNPQQQSPTVIMQQMASPNMMAAYIDAFQQQT GQSLQYIATVDAHNNGYNKAQFITAAPNTLLSGTYQLPEGFVGLQNGGIS VIPSMQLAATPSTVLGTIIQPQPTLQCGVVSADQMVLGSTGGMFLTAQPM YYGLETIVSNTVMQSSQFVSASVPGVMAASSSFSTTTQVFQASKLEPIMD VPSGFVIVNPHAPLADTTLGSSxxITCxxxxVTMNVSPSVTV--xxPPPL PPP----xAxPPPPSPQVNIPISQ-PPPLPTPRLSVPLTQPNVQTSQAPW RYSYNSPQNVYMASPKDSDHYTSSASQHLRATFPVEKCSCRKSETLNVKP PVTLPIYVSSPHTASPTRTQSSITEQKSVSSASVQTSAPVTPARQPVxx- IQRQTRLIPELSPQSKKIPEKTNKIN------------------------ -------------------------------------------------- --GMQGFSLKSLKMKPLICVSHEISKKEVTTLPVPIAQNNTNN-ESKESP PNRSNGITPHQNVKIIVPLKDKKLPNDYLPNVTYEIHSQDGFVCKSSSIT EVWQKVFEAVQEARKAHKMPPLPRNPFDGTVNGLQMLGLKHNGLRYLVEQ LPGAARCFKYKPRFHKQQPVGVDKESQPRENLSGCARAERFKTRSPYDMF GWLASRHRKPPKLLTPTDNDS-ISNRRATSTNLPMAMRFRYLKETSKEAV GVYRSHIHGRGLFCLRNIELGEMVIEYAGEVIRSTLTDKREKYYESKDIG CYMFRIDDHLVVDATMRGNAARFINHSCE--------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- --------PNCYSRVVDILGMKHILIFALRRIHQGEELTYDYKFPFEDDK IPCTCGSRKCRKYLN >Tte -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ---------------------------AGRQFNGFTSQEIELAISLVKKT YSKDLDVDCKLNENKYVRLWDSFSKELQNLPSDSKFRPNVSKSEKTNNSE ETDDESFDVGGKKNGIxTSKIPLKSSLHSDTSRSIQSSSKDTSKSTD-SI VCDDESCDSDELTEYDPSKKSLDPSLWSCSSGGKVILRKARLKLKSPVAK SIVDGPFSATTSRPSSxWPRLATSDSDRFQNAFVSVFRSQRQIRSPLFLM EVATLAFGSQPVARTMDPCVASVAGNNKKHSPRPGRSVLVAASWSRRPGR KPGPSSSTPGTVICGVCGAVRFYRFVKQARKFKILCCESCRKFISKIMRR QMEAMPPVGCQRGDGKCTVPPILRSQQWRATNKKISCAYKARCPACWLKM CLQAFKMPENLHKKLTRMLPSFMRKPPFIYIKQEKTSTASAQEESAEITG SSPNHFIKLEPFHDEEMNDKRHKRKAALDSFIKITPNRQVEEKKKKKRVD AIGSHKQKRLTHIRTSKILKKAAKNLSKSKEDKFSSRSLKKKAKEKNKKV NGSKVRKKAGSLSGVLDDSRR----------------------------- -------------------------QCQELKGPRVKHVCRSASIVLGQSQ ATFPPKIIEKKPVKSVQRSVKVPKKNKSHSNHMIDKxxAKHETERIQNNH IKSEANTLGMEASQPVYEIASISSGVSTRETSPLPVVRSKVVKQPAPVLP PLI----------------------------------------------- -------------------------------------------------- -------------------------------------------------- ------------------------------------xxxxxxxSRAATTY ASMYxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx xxxxxxxxxxxxxxxxxxxxDFWESYDPEEVSNTGFALIGSEPFSVRALC FLCGSAGHExxIHCxxxxEPYHPFCVEDGYCRSSLANCADEWRCDWVCRR CTMCHSCGQGLGQQVSCQRCHKIYHIECLGTDRITSRVHSPDRPW----- -------------------------------------------------- -----------------------------------MMECGQCKSWVHAKC EGLSDEKYQVLSYLPESVEFVCRLCCTLPPAPWWFAVEEELKAGFLGVLK AISKNRKACALLKWSPKKKCMCKSPIFSKTIDSQERSEHSDSSLEDLNSV NL------------------------------------------------ -------------------------------------------------- -------------------------------------------------- ---------------DHPHSFEVEGIDPGIIFSKDSSSDITETDGSVKNQ RQQFLLKDYAVCVKNVYTKPVISSPISIQVEDQLSGLSPDSTFSDVCLKS PNKTLMVSMATPPSDSGIGSTDDELKLSTEEETEEVKDGLAEIDFISNVE CALPTKLTPTKQLEPVVVPDKSPLGLDTSKTEGFAASRDCYCAEASSGKL TPTLLRIRKKISSNEYSSLLQFHQEMEHIINVTHHLDLVKTYHNALIEVF PWFDPKLAKVSSKNTGKSILIASPSKSGEHPSDKPLLEDSQENLCREVSK FNPPKGDLKYYYSDHIVEDMRTCMFCKGLGDGLPTREGRLLYCGQNGWTH ANCALWSAEVFEEIDGSLQNVHSAISRGRMIRCRLCGKKGASVGCCTRNC AETYHFYCALKNKCALMDDKTVFCPSHRKDASGKRLTEGSDFDLARPIYV ELDRKKKKYVEPNIVRFMIGSLIVENLGEFVARVSDNSEAIIPMEFCCTR LYWSSLEPWRIVRYNMKITMRTCKPQESQDLGKNITVDHTKEKNVVDQVL REISQWHHDLNSSKGQSDDVKVNCDLLISPSKKNNSCQTDTLNVKAKRNF KFTEERKVAREVLDHILDSVCREVDDSLTDPQNSADLLPPELKDAIFEDL PHDLLDGISMQDIFPKLMNVEEVSTVETCFGTESLKEGKELSEEALLSSD IEAISVISNNQDISLKNIRSEAAIELASQTDLWFESNDCKDETSLLEDDC FITNIPKEYLHIGATKDLKRSKSDGIPQQIRRKLSCGSISQHRSCSLTWS CKLDGPHKRRKGSRLAGRGSEDDSSRLITTAESAGDKAHRLQELRMPSIA STVAEGVRELKYCFEDDATSSEGAAGVRRRPILPKEEGKENKCMSWNDRI LQKLPQLDGAIDSSSSSEEGSPPRDNYVSEFTPHRTLLYAPSVIEANEEE PVRCDRCHRTYRTRTSFERHLPTCSSDFILSTSESDSENARSSEEEGVKY QPTTVSSSKSVFSPQKNVISSGQSCIIEESPTQLLNQPSECLNNVKPVFD SNIIPITKSQTKQKPIPKPILINGRQRGRAVNKQKLSAVRQQNHSSMMNH SLSPHSQQVHPIIHCQPQSNPQQQSPTVIMQQMASPNMMAAYIDAFQQQT GQSLQYIATVDAHNNGYNKAQFITAAPNTLLSGTYQLPEGFVGLQNGGIS VIPSMQLAATPSTVLGTLIQPQPTLQCGVVSADQMVLGSTGGMFLTAQPM YYGLETIVSNTVMQSSQFVSASVPGVMAASSSFSTTTQVFQASKLEPIMD VPSGFVIVNPHAPLADTTLGSSxxITCxxxxVSMNVSPSVTV--xxPPPL PPPxx--PHPPPPPPPQVHIPISQ-PPPLPTPRLSVPLTQPNVQTSQAPW RYSYNNPQNVYMASPKDNDHYTSSASQHLRATFPVEKCSCRKSETLNIKP PVTLPIYVSSPHTASTTRTQSSITEQKSVSSASVQTSAPVTLARQPV-TP VQRQTRLIPELSPQSKKIPEKTNKVN------------------------ -------------------------------------------------- --GMQGFSIKSLKMKPLVCVSHEISKKEVTTIPVPITQESANN-ESKESP PNRSNGITPHQNVKIIVPLKDKKLPNDYLPNVTYEIHSQDGFVCKSSSIT EVWQKVFEAVQEARKAHKMPPLPRNPFDGTVNGLQMLGLKHNGLRYLVEQ LPGAARCFKYKPRFHKQPPVGVDKESRPCENLSGCARAERFKTRSPYDMF GWLASRHRKPPKLLTPTDNDSAISNRRATSTNLPMAMRFRYLKETSKEAV GVYRSHIHGRGLFCLRNIELGEMVIEYAGEVIRSTLTDKREKYYESKDIG CYMFRIDDHLVVDATMRGNAARFINHSCE--------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- --------PNCYSRVVDILGMKHILIFALRRIHQGEELTYDYKFPFEDDK IPCTCGSRKCRKYLN >Tpa M------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------GKFPGKPSKTLNRKRVKVENCPVSQ ENDSLKAAENIYLRLAVFNEIFGNDKQAGRQFNGFTSQEIELAISLVKKT YSKDLDVDCKLNENKNVRLWDSFSKELQNLPSDSKFRPNVSKSEKTNNSE ETDDESFDVGGKKNGIxTSKIPLKSSLHSDTSRSIQSSSKDTSKSSD-SI VCDDESCDSDELTEYDPSKKSLDPSLWSCSSGGKVILRKARLKLKSPVAK SIVDGPFSATTSRPSS---------------------------------- -------------------------------------------------- ---ASSSTPGTVICGVCGAVRFYRFVKQARKFKILCCESCRKFISKIMRR QMEAMPPVGCQRGDGKCTVPPILRSQQWRATNKKISCAYKARCPACWLKM CLQAFQMPQNLHKKLTRMLPSFMRKPPFIYIKQEKTSTASAQEESAEITG SSLNHFIKLEPFHDEEMNDKRHKRKAALDSFIKITPNRQVEEKKKKKRVD AIGSHKQKRLTHIRTSKILKKAAKNLSKSKEDKFSSRSLKKKAKEKNKKV NGSK---------------------------------------------- --------------------------CQELKGPRVKHVCRSASIVLGQSQ ATFPPKIIEKKPVKSMQRSVKVPKKNKSHSNHVADKxxAKHETERIQNNH IKSEANTLGMESSQPVYEIASISSGVSTRETSPLPVVRSKVVKQPAPVLP PLL----------------xxxxxxxx----------------------- -------------------------------------------xxxxAVV APQLTLACTATxxxxxxxLNLQVERITINLNLRLERYTLTCVLVL----- ------------------VRTLPISNISNVPEPQLQICI----------- -------------------------------------------------- --------------------DFWESYDPEEVSNTGFALIGSEPFSVRALC FLCGSAGHExxIHCxxxxEPYHPFCVEDGYCRSSLANCADEWRCDWVCRR CTMCHSCGQGLGQQVSCQRCHKIYHIECLGTDRITSRVHSPDRPW----- -------------------------------------------------- -----------------------------------MMECGQCKSWVHAKC EGLSDEKYQVLSYLPESVEFVCRLCCTLPPAPWWFAVEEELKAGFLGVLK AISKNRKACALLKWSPKKKCMCKSPIFNKTIDSQERSEHSDSSLEDLNSV NLGNQEVxSAKGLKKxxxxxSEEIKNSCNLTPQVKVxQEDQSxxSxxxDN STxxxEEKSSSTKCFDDLVNRGIKNSISSDSHNNTNKESKNITDGNLLGD SLSYTENNISSETVLKDDKNFDYPGTHGSLIVKFKKMYPEEIYVTRxxxx xxxxxxxxxxxxxxxDHPHSFEVEGIDPGIIFSKYSSSDITETDGSVKNQ RQQFLLKDYAACVKNVYTKPVISSPISIQVEDQLSGLSPDSTFSDVCLKS PNKTLMVSMATPPSDSGIGSTDDELKLSTEEETEEVKDGLAEIDFISNVE CALPTKLTPTKQLEPVVVPDKSPLGLDASKTEGFAASRDCYCVEASSGKL TPTLLRIRKKISSNEYSSLLQFHQEMEHIINVTHHLDLVKTYHSALIEVF PWFDPKLAKVSSKNTGKSILIASPSKSGEHPSDKPLLEDSQENLCREVSK FNPPKGDLKYYYSDHIVEDMRTCMFCKGLGDGLPTREGRLLYCGQNGWTH ANCALWSAEVFEEIDGSLQNVHSAISRGRMIRCRLCGKKGASVGCCTRNC AETYHFYCALKNKCALMDDKTVFCPSHRKDASGKRLTEGSDFDLARPIYV ELDRKKKKYVEPNIVRFMIGSLIVENLGEFVARVSDNSEAIIPMEFCCTR LYWSSLEPWRIVRYNMKITMRTCKPQESQDLGKNITVDHTKEKNVVDQVL REISQWHHDLNNSKDQSDDVKVNCDLFISPSKKNNSCQTDTLNVKAKRNF KFTEERKVAREVLDHILDSVCREVDDSLTDPQNSADLLPPELKDAIFEDL PHDLLDGISMQDIFPKLMNVEEVSTAETCFGTESLKEGKELGEEALLSSD IEAISVISNNQDISLKNIRSEAAIELASQTDLWFESNDCKDETSLLEDEC FITNIPKEYLHIGTTKDIKRSKSDGIPQQIRRKLSCGSLSQHRSCSLTWS CKLDGPHKRRKGSRLAGRGSEDDSSRLITTAESAGDKAHRLQELRMPSIA STVAEGVRELKYCFEDDATSSEGAAGVRRRPTLPKEEGKENKCMSWNDRL LQKLPQLDGAIDSSSSSEEGSPPRDNYVSEFTPHRTLLYAPSVIEANEEE PVRCDRCHRTYRTRTSFERHLPTCSSDFILSTSESDSENARSSEEEGVKY QPTTISSSKSVFSPQKNVISSGQSCIIEESPTQLLNQPSECLNNVKPVFD SNIIPTTKSQTKQKPIPKPILINGRQRGRAVNKQKLSAIRQQNHSSMMNH SLSPHSQQVHPIIHCQPQSNPQQQSPTVIMQQMASPNMMAAYIDAFQQQT GQSLQYIATVDAHNNGYNKAQFITAAPNTLLSGTYQLPEGFVGLQNGGIS VIPSMQLAATPSTVLGTLIQPQPTLQCGVVSADQMVLGSTGGMFLTAQPM YYGLETIVSNTVMQSSQFVSASVPGVMAASSSFSTTTQVFQASKLEPIID VPSGFVIVNPHAPLADTTLGSSxxITCxxxxVSMNVSPSVTV--xxPPPL PPPxxxxxxxPPPPPPQVHIPISQ-PPPLPTPRPSVPLIQPNVQTSQAPW RYNYNSPQNVYMASPKDNDHYTSSASQHLRATFPVEKCSCRKSETLNFKP PVTLPIYVSSPHTASTTRTQSSITEQKSVSSASVQTSAPVTLARQPV-TP IQRQTRLIPELSPQSKKIPEKTNKVNGTFNNSNNMMVLSQAKNNTNKSNP LRFVLHKQTQDGVYKVDNLNPCKLENNKVIPTTSSNNINNININGNKTII NTGMQGFSIKSLKMKPLVCVSHEISKKEVTTIPVPKIQDSANN-ESKESP PNRSNGITPHQNVKIIVPLKDKKLPNDYLPNVTYEIHSQDGFVCKSSSIT EVWQKVFEAVQEARKAHKMPPLPRNPFDGTVNGLQMLGLKHNGLRYLVEQ LPGAARCFKYKPRFHKQPPIGVDKESRPCENLSGCARAERFKTRSPYDMF GWLASRHRKPPKLLTPTDNDSAISNRRATSTNLPMAMRFRYLKETSKEAV GVYRSHIHGRGLFCLRNIELGEMVIEYAGEVIRSTLTDKREKYYESKDIG CYMFRIDDHLVVDATMRGNAARFINHSCE--------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- --------PNCYSRVVDILGMKHILIFALRRIHQGEELTYDYKFPFEDDK IPCTCGSRKCRKYLN >Tsi M------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------GxFPGKPSKTLNRKRVKVENCPVSQ ENDSLKAAENIYLRLAVFNEIFGNDKQVGRQFNGFTSQEIDSAISLVNKT YNKDLAVDCKSNENKNVRYWDSFSQELQNLPSDSKSRPNVSKSEKTNNSE ETDDQSFDVEGKKNGI---------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ---xSSSTPGTVICGVCGAVRFYRFVKQARKFKILCCESCRKFISKIMRR QTEAMPPLGCQRGDGKCTVPPILRSQQWRATNKKISCGYKARCPACWLKM CLQAFQMPENLHKKLTRMLPSFMRKPPFTYIKQEKTSTASAQEEPGETTG SSPNHFIKLEPFHDEEMNDKRHKRKAALDSFIKITPNRQVEEKKKNKRVD AIGSHKQK------------------------------------------ --------------------xxxxxxxxxxxxxxxxxxxxxxxxxxxxxx xxxxxxxxxxxxxxxxxxxxxxxxxQCQELKGPRVKHVCRSASIVLGQSQ ATFPPKIMEKKPVKSVQRSIKVPKKNKSHSNHVADKxxAKHETERNQNSH IKSEVHTLGMEASQPVCEIASISSCVSTRETSPLPVARSKVVKQPAPILP PMVxxxxxxxxxxxxxxxxx------------------------------ -------------------------------------------------- ------------------LNLQVERITLNLNLQLERITLTCNPEL----- ------------------VRTLPISTISNVPKPQLQICI----------- -------------------------------------------------- --------------------DFWESYDPEEVSNTGFALIGSEPFSVRAMC FLCGSAGQExxIHCxxxxEPYHPFCVEDGYCRSSLANCADEWRCDWVCRR CTMCHSCGQGLGQQVSCQRCHKIYHIECLGTDRITSRVHSPDRPW----- -------------------------------------------------- -----------------------------------MMECGQCKSWVHAKC EGLSDEKYQVLSYLPESVEFVCRLCCTLPPAPWWLAVEEELKAGFLGVLK AISKNRKACALLKWSPKKKCMCKSPIFSKTIDSQERSEHSDSSLEDLNSV NLSNQEVIAAKSLKKSLFVGSEEIKKSCNLTPQIKLGQEEQSxxTxxxDN ATxxxEEKSSSTKCFDDLINK----------------------------- -------------------------------------------------- ---------------DHPHSFEVEGIDQAIICSKDSSRDITETDGSVKNQ RQPFLLKDYAARVKNIYTKPVISSPISIQVEDQLSGLSPDSTLSDVCLKS PNKTLMVSMATPPSDSGIGSTDDELKLSTEEETEEGKDGLAEIDFISNVE CALSTKLTPTDQLEPVVVPDKSLLVLDANKTEGFAASRDCYCAEASSGKL TPTLLRIRKKISSNEYSSLLQFHQEMEHIINVTHHLDLVNTYHNALIEVF PWFDPKLAKVSSKNTGKSILIASPSKSGEHPSDKSRLEDSQENLCREVSK FNPPKGDLKYYYSDHIVEDMRTCMFCKGLGDGLPTREGRLLYCGQNGWTH ANCALWSAEVFEEIDGSLQNVHSAISRGRMIRCRLCGKKGASVGCCTRNC AETYHFNCAIKNKCALMDDKTVFCPSHRKDAAGKRLTEGSDFDLARPIYV ELDRKKKKYVEPNIVRFMIGSLIVENLGEFVARVSDNSEAIIPMEFCCTR LYWSSLEPWRIVRYNMKITMRACKPQESQDLGKNITVDHTKDKNVVDQVL REISQWHHDLSSSKDQPDDVKVNCDLFISPLKKNNSCQTDTLNVKAKRNF KFAEEKKVAREVLGHILDNICKEVDDNLADPQNSADLLPPELKDAIFEDL PHDLLDGISMQDIFPKLMNVEEVSTVETCFGTESLKEGKELSEEALLSSD IEAISVISNNQD-SLKNIRSEAAMEFASQTDPWFETNDCKDETSLLEDEC FITNIPKEYLHIGTTKDLKRSKSDGIPQQIRRKLSCGSISQHRSCSLTWS CKLDGPHKRRKGSRLAGRGSEDDSSRLITTAEGAGEKAHRLQELRMPSIA STVAEGVRELKYCFEDDATSSEGAAGVRRRPILPKEEGKENKCMPWNDRL LQKLPQLDGAIDSSSSSEEGSPPRDNYVSEFTPHRTLLYAPSVIEANEEE PVRCDRCHRTYRTRTSFERHLPTCSSDFILSTSESDSENARSSEEEGVKY QPITTSSSKSVFSPQKNVISSGQACIIEQSPTRMINKPSECLNTVKPVFD SNIIPITKSQTKQKPIPKPILINGRQRGRAVNKQKISAIRQQNHSSMINQ SLSPHSQQVHPIIHCQPQSNPQQQSPTVIMQQMASPNMMAAYIDAFQQQT GQSLQYIATVDAHNNGYNKAQFITAAPNTLLSGTYQLPEGFVGLQNGGIS VIPSMQLAATPSTVLGTIIQPQPTLQCGVVSADQMVLGSTGGMFLTAQPM YYGLETIVSNTVMQSSQFVSASVPGVMAASSSFSTTTQVFQASKLEPIMD VPSGFVIVNPHAPLADTTLGSSxxITCxxxxVTMNVSPSVTV--xxPPPL PPP----xAPPPPPSPQVNIPISQ-PPPLPTPRLSVPLTQPNVQTSQAPW RYSYNSPQNVYMASPKDNDHYTSSASQHLRATFPVEKCSCRKSETLNVKP PVTLPIYVSSPHTASPTRTQSSITEQKSVSSASVQTSAPVTPARQPV-T- IQRQTRLIPELSPQSKKIPEKTNKIN------------------------ -------------------------------------------------- --GMQGFSLKSLKMKPLICVSHEISKKEVTTLPVPIAQNNTNN-ESKESP PNRSNGITPHQNVKIIVPLKDKKLPNDYLPNVTYEIHSQDGFVCKSSSIT EVWQKVFEAVQEARKAHKMPPLPRNPFDGTVNGLQMLGLKHNGLRYLVEQ LPGAARCFKYKHRFHKQQPVGVDKESQPRENLSGCARAERFKTRSPYDMF GWLASRHRKPPKLLTPTDNDS-ISNRRATSTNLPMAMRFRYLKETSKEAV GVYRSHIHGRGLFCLRNIELGEMVIEYAGEVIRSTLTDKREKYYESKDIG CYMFRIDDHLVVDATMRGNAARFINHSCExxxxxxxxxxxxxxxxxxxxx xxxxxxxxxxxxxxxxxxxxxxxxxVxxxxxxxxxxxxxExxLVTGVVxx xxxxxxGASVTxxxCVPYMRxxxxxxxxxxxxxxxxxxxxxxxxxxxx-- -------------------------------------------------- -----------------------------------xxxxxxxxxxxxxxx xxxxxxxS------------------------------------------ --------------- >Tbi xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ---------------------------------------xx--------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ---------------PQVHIPISQ-PPPLPTPRLSVPLTQPNVQTSQAPW RYSYNNPQNVYMASPKDNDHYTSSASQHLRATFPVEKCSCRKSETLNIKP PVTLPIYVSSPHTASTTRTQSSITEQKSVSSASVQTSAPVTLARQPV-TP VQRQTRLIPELSPQSKKIPEKTNKVNGTFNNSNNMMVLSQAKNNTNKSNP LRFVLHKQTQDGVYKVDNLNPCKLENNKVIPTTSSNNINNININGNKTII NTGMQGFSIKSLKMKPLVCVSHEISKKEVTTIPVPITQESANN-ESKESP PNRSNGITPHQNVKIIVPLKDKKLPNDYLPNVTYEIHSQDGFVCKSSSIT EVWQKVFEAVQEARKAHKMPPLPRNPFDGTVNGLQMLGLKHNGLRYLVEQ LPGAARCFKYKPRFHKQPPVGVDKESRPCENLSGCARAERFKTRSPYDMF GWLASRHRKPPKLLTPTDNDSAISNRRATSTNLPMAMRFRYLKETSKEAV GVYRSHIHGRGLFCLRNIELGEMVIEYAGEVIRSTLTDKREKYYESKDIG CYMFRIDDHLVVDATMRGNAARFINHSCE--------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- --------PNCYSRVVDILGMKHILIFALRRIHQGEELTYDYKFxxEDDK xxxxxxxRKCRKYLx