>Tge -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -----MTNRLYASDEVRAMFMLIQNPVFAAQSSYTILAHLLRQMVNLPST DHQLLVAWFKILEVEKLRMMVRHLQQFITIRQFPPADKSLPPLxxxRWWI PMATKTxxxxxKSxxxMDNSLQPxxxxxxxxRWWIPISTKFLALIxxxxx xxxxxxxxxxxxxxxxxxAxxxxALIN----------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------AANNASNPPLLDYSEFYNS ALDHVDLMQDYFNWQSPQRPGQFAYCQYPFILSIVAKRIILTKDSEQQMI LTARRSLVAKVARHQAPQIDIFFLNIHIRRSHLVSDSLNE-----IASKQ KDLKKKLKVSFVGEPGLDMGGLTKEWFLLLIRQIFHPDYGMFVYHPNSRC YWFSTDQEGNLREYNLIACKSYDDSLPSILVSSGVLMGLAVYNSIILDLH FPSICYRKLLSPPVVPPSDSARVGVVKSPTMEDLAEIMPDVSRGLAELLA YEGNVEEDMCLTF------------QVSLEEYGQVKTYKLREEGENVPVT NESREEYVNLYLDWILNAAIYEQFRAFYLGFHSVCASNALI--------- --MLRPEEVEMLVCGSPTLDLNELRKVTEYDGYKADDVIIIDFWEVLQSL SDELKKKFLLFATGSDRVPVGGMGEMTFKITRVTNKPDNLPEAHTCFNQL VLPNYSTQEMLRQKLIIAISNAEGFGLE >Tpa -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ------------------------------------------QDSEQQMI LTARRSLVAKVARHQAPQIDIFFLNIHIRRSHLVSDSLNE-----IASKQ KDLKKKLKVSFVGEPGLDMGGLTKEWFLLLIRQIFHPDYGMFVYHPNSRC YWFSTDQEGNLREYNLIACKSYDDSLPSVLVSSGVLMGLAVYNSIILDLH FPSVCYRKLLSPPVVPPSDSARVGVVKSPTMEDLAEIMPDVSRGLAELLA YEGNVEEDMCLTF------------QVSLEEYGQVKTYKLREEGENVPVT NESREEYVDLYLDWILNAAIYEQFRAFYLGFHSVCASNALI--------- --MLRPEEVEMLVCGSPTLDLNELRKVTEYDGYKADDVIIIDFWEVLQSL SDELKKKFLLFATGSDRVPVGGMGEMTFKITRVTNKPDNLPEAHTCFNQL VLPNYSTQEMLRQKLIIAISNAEGFGLE >Tce -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ------------------------------------------QDSEQQMI LTARRSLVAKVARHQAPQIDIFFLNIHIRRSHLVSDSLNE-----IASKQ KDLKKKLKVSFVGEPGLDMGGLTKEWFLLLIRQIFHPDYGMFVYHPNSRC YWFSTDQEGNLREYNLI----------------GVLMGLAVYNSIILDLH FPSVCYRKLLSPPVVPPSDSARVGVVKSPTMEDLAEIMPDVSRGLAELLA YEGNVEEDMCLTF------------QVSLEEYGQVKTYKLREEGENVPVT NESREEYVDLYLNWILNAAIYEQFRAFYLGFHSVCASNALIxxxxxxxxx xx------------------------------------------------ -------------------------------------------------- ---------------------------- >Tms -------------------------------------------------- ---------------------------------------RPSQSTKVTLC VVFVETQPVHRGDTRPSQSTERPSQSTEVTLLSGSKLGDEDVTTCSACRV TIHHQHGAGPNLRAACPFCGQPYTSTPATPTGQNDQPLGVGVGAGRVRGQ RSSSDPVVPCFRLPSI----------------------QEPPQENQPARY GRIGSFMVNRLGGVNITSLGNFLLRPGSEASLPPI--------------- -------------------------------------------------- ----------xxxxYLPSISGVRYLPSxxxxxxxxxxxxxxxxxxxxxxx xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx----------- --------------------------------------------DVDGKF LSVAASPTSTPESGFRSALSVENLACSDLEENLPVLVPQYPIRTKTREDF LISYYQQRQIIICIQAxPVPTPKVVPPPExxxxxxxxxxxxxxxxxxxxx xxxxxxxxxxxxGRxxxxxxxPV--------------------------- -------------------------------------------------- --------NPRPSIETYFRRQALNCLVAW--------------------Q DVRRAQQTENFSSLQRFYMRTFETFLEMCALFKINRDEDGSSPDDPTLNM ELLYAVHDALKSL---------------------YRTIQKLLVRLLYQVI TSLVVMTNRLYASDEVRAMFMLIQNPVFAAQSSYTIFAHLLRQMVNLPST DHQLLVTWFKILEVEKLRMMVRHLQQFITIRQFPPADKSLPPLxxxRWWI PMATKT-------------------------------------------- ----------------------LALINR---------------------- -------------------------------------------------- --------------------------------IxxxExxxxxxxxxxxxx xxxxxxxxxxx----------------xxxxAANNASSPPLLDYSEFYNS ALDHVDLMQDYFNWQSPQRPGQFAYCQYPFILSIVAKRIILTKDSEQQMI LTARRSLVAKVARHQAPQIDIFFLNIHIRRSHLVSDSLNE-----IASKQ KDLKKKLKVSFVGEPGLDMGGLTKEWFLLLIRQIFHPDYGMFVYHPNSRC YWFSTDQEGNLREYNLI----------------GVLMGLAVYNSIILDLH FPSVCYRKLLSPPVVPPSDSARVGVVKSPTMEDLAEIMPDVSRGLAELLA YEGNVEEDMCLTF------------QVSLEEYGQVKTYKLREEGENVPVT NESREEYVDLYLNWILNAAIYEQFRAFYLGFHSVCASNALI--------- --MLRPEEVEMLVCGSPTLDLNELRKVTEYDGYKADDVIIIDFWEVLQSL SDELKKKFLLFATGSDRVPVGGMGEMTFKITRVTNKPDNLPEAHTCFNQL VLPNYSTQEILRQKLIIAISNAEGFGLE >Tps -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ----------------------------------YRTIQKLLVRLLYQVI TSLVAMTNRLYASDEVRAMFMLIQNPVFAAQSSYTIFAHLLRQMVNLPST DHQLLVTWFKILEVEKLRMMVRHLQQFITIRQFPPADKSLPPLxxxRWWI PMATKT-------------------------------------------- ----------------------LALIN----------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------AANNASSPPLLDYSEFYNS ALDHVDLMQDYFNWQSPQRPGQFAYCQYPFILSIVAKRIILTKDSEQQMI LTARRSLVAKVARHQAPQIDIFFLNIHIRRSHLVSDSLNE-----IASKQ KDLKKKLKVSFVGEPGLDMGGLTKEWFLLLIRQIFHPDYGMFVYHPNSRC YWFSTDQEGNLREYNLI----------------GVLMGLAVYNSIILDLH FPSICYRKLLSPPVVPPSDSAHVGVVKSPTMEDLAEIMPDVSRGLAELLA YEGNVEEDMCLTF------------QVSLEEYGQVKTYKLREEGENVPVT NESREEYVDLYLNWILNAAIYEQFRAFYLGFHSVCASNALI--------- --MLRPEEVEMLVCGSPTLDLNELRKVTEYDGYKADDVIIIDFWEVLQSL SDELKKKFLLFATGSDRVPVGGMGEMTFKITRVTNKPDNLPEAHTCFNQL VLPNYSTQEILRQKLIIAISNAEGFGLE >Tdi xNEELSLLSWGGGRVRTSTQLLSVTGETELPCPxxHPEQVGQELSVGRWR VRASPNLGGSVPMSWVWERFRNxxRSxxDDDADDLDLEQRPSQST----- ---------------------------EVTLLSGSKLGDEDVTTCSACRV TIHHQHGAGPNLRAACPFCGQPYTSTPATPTGQNDQPLGVGVGAGRVRGQ RSSSDPVVPCFRLPSIVSPSPQQGLVLVVGSATNAEYPQEPPQENQPARY GRIGSFMVNRLGGVNITSLGNFLLRPGSEASLPP---------------- -------------------------------------------------- ---------------------------Ixxxxxxxxxxxxxxxxxxxxxx xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx----------- ----------------xxxxxxxxxxxxxLPTKTVPGYPLFLFQDVDGKF LSVAASPASSPESGFRSALSVENLTCSDLEENPPVLVPQYPIRAKTREDF L------------------------------------------------- ----------------------QFQLSSATSDYNTYSSxTSPHPQSRPSP GVRSVILSSPAPGGGIDRATRVVRQCFVCHGCH----------------- ---VSSRSNPRPSIGSYFRRQALNGLVAWxECRSGQMTDCVVYLQASRLQ DVRRAQQTENFSSLQRFYMRTFETFLEMCALFKMNRDEDGSSPDDPTLNM ELLYAVHDALKTL---------------------YRTIQKLLVRLPNQVI TSLVDMTNRLYASDEVRAMFMLIQNPVFAAQSSYTIFAHLLRQMVNLPST DHQLLVTWFKILEVEKLRMMVRHLQQFITIRQFPPADKSLPPLxxxRWWI PMATKT-------------------------------------------- ----------------------LALIN----------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------AANNASSPPLLDYSEFYNS ALDHVDLMQDYFNWQSPQRPGQFAYCQYPFILSIVAKRIILTKDSEQQMI LTARRSLVAKVARHQAPQIDIFFLNIHIRRSHLVSDSLNE-----IASKQ KDLKKKLKVSFVGEPGLDMGGLTKEWFLLLIRQIFHPDYGMFVYHPNSRC YWFSTDQEGNLREYNLI----------------GVLMGLAVYNSIILDLH FPSICYRKLLSPPVVPPSDSARVGVVKSPTMEDLAEIMPDVSRGLAELLA YEGNVEEDMCLTF------------QVSLEEYGQVKTYKLREEGENVPVT NESREEYVDLYLNWILNAAIYEQFRAFYLGFHSVCASNALI--------- --MLRPEEVEMLVCGSPTLDLNELRKVTEYDGYKADDVIIIDFWEVLQSL SDELKKKFLLFATGSDRVPVGGMGEMTFKITRVTNKPDNLPEAHTCFNQL VLPNYSTQEILRQKLIIAISNAEGFGLE >Tsi MSG----------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------Q DVRRAQQTENFSSLQRFYMRTFETFLEMCALFKMNRDEDGSSPDDPTLNM ELLYAVHDALKTL---------------------YRTIQKLIVRLLDQVI TSLDAxTNRLYASDEVRAMFMLIQNPVFAAQSSYTIFAHLLRQMVNLPST DHQLLVTWFKILEVEKLRMMVRHLQQFITIRQFPPADKSLPPLxxxRWWI PMATKT-------------------------------------------- ----------------------LALIN----------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------AANNASNPPLLDYSEFYNS ALDHVDLMQDYFNWQSPQRPGQFAYCQYPFILSIVAKRIILTKDSEQQMI LTARRSLVAKVARHQAPQIDIFFLNIHIRRSHLVSDSLNEDLLSxIASKQ KDLKKKLKVSFVGEPGLDMGGLTKEWFLLLIRQIFHPDYGMFVYHPNSRC YWFSTDQEGNLREYNLI----------------GVLMGLAVYNSIILDLH FPSVCYRKLLSPPVVPPSDSTRVGVVKSPTMEDLAEIMPDVSRGLAELLA YEGNVEEDMCLTFxCA----KCCVPQVSLEEYGQVKTYKLREEGENVTVT NESREEYVDLYLNWILNAAIYEQFRAFYLGFHSVCASNALI--------- --MLRPEEVEMLVCGSPTLDLNELRKVTEYDGYKADDVIIIDFWEVLQSL SDELKKKFLLFATGSDRVPVGGMGEMTFKITRVTNKPDNLPEAHTCFNQL VLPNYSTQEILRQKLIIAISNAEGFGLE >Tte xGQK---------------------------------------------- ------------TAW----------------------------------- -------------------------------------------------- -------------------------------------------------- --------------------------------------QEPSQENQPARY GRIGSFMVNRLGGVNITSLGNFLLRPGSEASLPPIxxxxxxxxxLxxxxx xxILVDSKDLLILVDSKDIxxLLESKxxxxxLESKDLLILVDSKDLMILL ESKxxMILxxx-------------------xxxxxxxxxxxxxxxxxxxx xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx xxxxxxxxDxxDLMILVDSKDILI------------------FVDVDGKF LSVAGSPASTPESGFRSALSVENLTCSDLEENLPVLVPQYPTRAKTREDF L------------------------------------------------- --------------------------------------xTSPHPQGRPSP GxxxVILNRPAPGGGIDRVTxxVRQCFVCxxxxxNTQHNSRPTIHSAVVI LxxVxxRSNPRPSIKSYFRRRALNCPVAW--------------------Q DVRRAQQTENFSSLQRFYMRTFETFLEMCALFKMNRDEDGSSPDDPTLNM ELLYAVHDALKGLxxxxxxTVLKSIINALLEENRYRTRQQLLMRLLYQVI TSLVAMTNRLYASDEVRAMFMLIQNPVFAAQSSYTIFAHLLRQMVNLPST DHQLLVAWFKILEVEKLRMMVRHLQQFITIRQFPPADKSLPPLxxxRWWI PMATKT-------------------------------------------- ----------------------LALISKSxxxAxESADPWLxxxxxxxxx xTLxxxxQCxxxxxxxxxxxxxxxxxxxQGxDxKTYLIGYxxxxxxxxxx xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx----------------- -------------------------------AANNASNPPLLDYSEFYNS ALDHVDLMQDYFNWQSPQRPGQFAYCQYPFILSIVAKRIILTKDSEQQMI LTARRSLVAKVARHQAPQIDIFFLNIHIRRSHLVSDSLNE-----IASKQ KDLKKKLKVSFVGEPGLDMGGLTKEWFLLLIRQIFHPDYGMFVYHPNSRC YWFSTDQEGNLREYNLI----------------GVLMGLAVYNSIILDLH FPSVCYRKLLSPPVVPPSDSARVGVVKSPTMEDLAEIMPDVSRGLAELLA YEGNVEEDMCLTF------------QVSLEEYGQVKTYKLREEGENVPVT NESREEYVDLYLEWILNAAIYEQFRAFYLGFHSVCASNALI--------- --MLRPEEVEMLVCGSPTLDLNELRKVTEYDGYKADDVIIIDFWEVLQSL SDELKKKFLLFATGSDRVPVGGMGEMTFKITRVTNKPDNLPEAHTCFNQL VLPNYSTQEILRQKLIIAISNAEGFGLE >Tcm -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ---------------------------------MNRDEDGSSPDDPTLNM ELLYAVHDALKTLxxxxxxxxxxxxxxxxxxxxxx--------------- ---------LYASDEVRAMFMLIQNPVFAAQSSYTIFAHLLRQMVNLPST DHQLLVTWFKILEVEKLRMMVRHLQQFITIRQFPPADKSLPPLxxxRWWI PMATKT-------------------------------------------- ----------------------LALIN----------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------AANNASNPPLLDYSEFYNS ALDHVDLMQDYFNWQSPQRPGQFAYCQYPFILSIVAKRIILTKDSEQQMI LTARRSLVAKVARHQAPQIDIFFLNIHIRRSHLVSDSLNE-----IASKQ KDLKKKLKVSFVGEPGLDMGGLTKEWFLLLIRQIFHPDYGMFVYHPNSRC YWFSTDQEGNLREYNLI----------------GVLMGLAVYNSIILDLH FPSVCYRKLLSPPVVPPSDSARVGVVKSPTMEDLAEIMP----------- ---------------xxxxxx----------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ---------------------------- >Tbi x------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -----------------------------------------------xxx xxxxxxxxxxxxxx------------------------------------ ----------xxxxxxxxxxxxxxxxxxxxxAANNASNPPLLDYSEFYNS ALDHVDLMQDYFNWQSPQRPGQFAYCQYPFILSIVAKRIILTKDSEQQMI LTARRSLVAKVARHQAPQIDIFFLNIHIRRSHLVSDSLNEDLMSxIASKQ KDLKKKLKVSFVGEPGLDMGGLTKEWFLLLIRQIFHPDYGMFVYHPNSRC YWFSTDQEGNLREYNLI----------------GVLMGLAVYNSIILDLH FPSVCYRKLLSPPVVPPSDSAHVGVVKSPTMEDLAEIMPDVSRGLAELLA YEGNVEEDMCLTF------------QVSLEEYGQVKTYKLREEGENVPVT NESREEYVDLYLEWILNAAIYEQFRAFYLGFHSVCASNALI--------- --MLRPEEVEMLVCGSPTLDLNELRKVTEYDGYKADDVIIIDFWEVLQSL SDELKKKFLLFATGSDRVPVGGMGEMTFKITRVTNKPDNLPEAHTCFNQL VLPNYSTQEILRQKLIIAISNAEGFGLE