>Tms -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -----------------------------------------------MAV SATMVYSSVASAVFYWFLWTTHKCGAFNLASQHAHVIVDPKGQVGSYFGF TVALRKQSDIGxENSWLQVVNxGPVEF----------------------- -----LHEPAVEKKANSLQIHSPTSQGQLVTFTC-------x-------- -----------------------------xxxxVYVEETRDVTFFSVTRN Vxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx------------------ -------------------------------------------------- -------------------------------------------------- LLVVGAPRANSTLQNHLNIYQPGVTYQCDLSQDNKCSQIVLDPTGNGKKL AANGFSYKHKKDNAWIGGAIDVVEGRENSPLVVCGPRWKNNINIDYYLMN GICYWSSPNSISRPDRKAEEWLPLLGxRMSKAEFKGAAPAFVWSESGKPF KKNCPQSTRPGLKTDLPDIGSLFYCK------------------------ ------SSTxxxxxxxxxxxx------------KQGYTIKPKHPDENSTE VFYYAYGEAGISVHLVxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx xxxxxxxxxxxxxxxxxxxxxxx--------------------------- -------------------------------------------------- ------------------------PSCLVRWGIFEENWASPAYDVAVFIF DFPWNNDMPLKILLELEGYQMGEYFGATLCVVDLNNDGLDDLVVGAPLHS LGIHNSGLPTGDEGRVYVYINQEEGRMTEVASEIMGSSVHGARFGSSIAN IGDINLDGYADIAVGAPYENSGRGVIYIYNGKPTGINPKHSQRIAASQID DAIFGFGISISKGLDIDGNHYNDVAVGAYDSGHAVVLKSRPVVSLHAEIT ADVRKISFNASHFRVAVCISFFGKFVRVIGVDLTMKVDPTYGRAQFYFDP GYSTNIYTYYVTLELGLPVCRNFTVKIKQGLQDFSKPIAVSLEYKLQDNL PIPVRRRRATEEFCKTCPILDPDMPPTVVLRVPYATGCGEEDTCRTDLKL TAELLNIKLPYIIGTLETVSLHVTVISLLEPAFLSRVIVEIPRETALVRM PPTCQQVSTTNTIKYLHLECDTGNPLIGDEKRVLELELDMKGVPAITKEL TFNVTAISVGDEQNNADNNVLIHVPLHTISDVRIVG-------------- -------------------------------------------------- KSSQDQLLYSKQNESKIEDLIVIHSYEVRNYGPSPVDSVQMEFQVPITLK AGGKTINFLKLYQPEVYLDNQPFNCKASKFPFYTDNISEGSGVSLDEPQS GALPDGSHRRRRSVNNQDGELSSLETLPINRTLFVNCSQPDTLCMTVTCA RVGPLLSSYTKAMVHLRMRANLRLL------------------------- -------DPIMDKKDVVLVSTNGVAIYQYLNNSLHPLSDNFNKTSVSTMF LGKIPAENIATWIIILAIIGGILIFMLLVLGLIK---------------- ----IEDEFQNDDEEL >Tte -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------MPLKILLELEGYQMGEYFGATLCVVDLNNDGLDDLVVGAPLHS LGIHNSGLPTGDEGRVYVYINQEEGRMTEVASEIMGSSVHGARFGSSIAN IGDINLDGYADIAVGAPYENSGRGVIYIYNGKPTGINPKHSQRIAASEID DAIFGFGISISKGLDIDGNHYNDVAVGAYDSGHAVVLKSRPVVSLHAEIT ADVRKISFNASHFRVAVCISFFGKFARVIGVDLTMKVDPTYGRAQFYFDP GYSTNIYTYYVTLELGLPVCRNFTVKIKQGLQDFSKPIAVSLEYKLQDNL PIPVRRRRATEEFCKTCPILDPDMPSTVVLRVPYATGCGEEDTCRTDLRL TAELLNIKLPYIIGTLETVSLHVTVISLLEPAFLSRVIVEIPRETALVRM PPTCQQVSTTNTIKYLRLECDTGNPLISDEKRVLELELDMKGVPANTKEL MFNITAISVGDEQNNADNNVLIHVPLHTISDVRIVG-------------- -------------------------------------------------- KSSQDQLLYSKQNESKIEDLIVIHTYEVRNYGPSPVDAVQMEFQVPITIK AGGKTINFLKLYQPEVYLDNQPFNCKASKFPFYTDDISEGSGVSLDESQS GTLPDVSHRRRRSVNNQDGELSSLETLPINRTLFVNCSQPDTLCMTVTCV RVGPLLSSYTKAMVHLRMRANLRLL------------------------- -------DPIMDKKDVVLVSTNGVAIYQYLNNSLRPLSDNFNKTSVSTMF LGKIPAENIATWIIVLAIIGGILIFMLLVLGLIK---------------- ----IEDEFQNDDEEL >Tce -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -----------------------------------------------xx- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------TGNGKKL AANGFSYKHKKDNAWIGGAIDVVEGRENSPLVVCGPRWKNNINIDYYLMN GICYWSSPNSISRPDRKAEEWLPLLGxxMSKAEFKGAAPAFVWSESGKPF KKNCPQSTRPGLKTNLPDIGSLFYCK------------------------ ------SST-----------FDPSFKANLVPxDKQGYTIKPKHPDENSTE VFYYAYGEAGISVHLV---------------------------------- ----------------------K--xxxxxExLxxAPGVFDWK------- -----------------GYSLGSGQFFQNASQTLYVSGAPRAANYKGKPQ PYGNRTIELKAQQNNQCLKGIEKQPSCLVRWGIFEENWASPAYDVAVFIF DFPWNNDMPLKILLELEGYQMGEYFGATLCVVDLNNDGLDDLVVGAPLHS LGIHNSGLPTGDEGRVYVYINQEEGRMTEVASEIMGSSVHGARFGSSIAN IGDINLDGYAxxxxxxPYENSGRxxIYIYNGKPTGINPKHSQRIAASQID DAIFGFGISISKGLDIDGNHYNDVAVGAYDSGHAVVLKSRPVVSLHAEIT ADVRKISFNASHFRVAVCISFFGKFVRVIGADLTMKVDPTYGRAQFYFDP GYSTNIYTYYVTLELGLPVCRNFTVKIKQGLQDFSKPIAVSLEYKLQDNL PIPVRRRRANEGI--TCPILDPDMPSTVVLRVPYATGCGEEDTCRTDLKL TAELLNIKLPYIIGTLETVSLHVTVISLLEPAFLSRVIVEIPRETALVRM PPTCQQVSTTNTIKYLHLECDTGNPLISDEKRVLELELDMKGVPANTKEL TFNVTAISVGDEQNNADNN------------------------------- -------------------------------------------------- ---------------------------VRNYGPSPVDSVQMEFQVPITLK AGGKTINFLKLYQPEVYLDNQPFNCKASKFPFYTDNISEGSGVSLDEPQS GALPDGSHRRRRSVNNQDGELSSLETLPINRTLFVNCSQPDTLCMTVTCA RVGPLLSSYTKAMVHLRMRANLRLL------------------------- -------DPIMDKKDVVLVSTNGVAIYQYLNNSLHPHSDNFNKTSVSTMF LGKIPAENIATWIIILAIIGGILIFMLLVLGLIKxGFFRRDKKDELQLLK EKSLIEDEFQNDDEEL >Tdi -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -----------------------------------------x-------- -----------------------------xxxxVCDEETRHVTFFSLTWN Vxxxx-------------------------xxxxxxR------------- ---------xxxxxRLTIPSLDSTRPLPSLLLTASELLLQVTELELPTLQ AALRxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx WLVVGAPRANSTLQNHLSIFQPGVTYQCDLSQDNKCSQIVLDPTGNGKKL AANGFSYKHKKDNAWIGGAIDVVEGRENSPLVVCGPRWKNNINIDYYLMN GICYWSSPNSISRPDRKAEEWLPLLGx----------------------- -------------------------------------------------- --------------------------------NKQGYTIKPKHPDENSTE VFYYAYGEAGISVHLV---------------------------------- ----------------------K----x---------------xxxxxxx xxxxxxxxxxxxxxxxxGYSLGSGQFFQNASQTLYVSGAPRAANYKGK-- ------------------------PSCLIRWGIFEENWASPTYDVSVFIF DFPWNNDMPLKILLELEGYQMGEYFGATLCVVDLNNDGLDDLVVGAPLHS LGIHNSGLPTGDEGRVYVYINQEEGRMTEVAGEIMGSSVHGARFGSSIAN IGDINLDGYA---------------------------------------- ----------------------xxxxxxYDSGHAVVLKSRPVVSLHAEIT ADVRKISFNASNFRVAVCISFFGKFARVIGADLTMKVDPTYGRAQFYFDP DYSTNIYTYYVTLELGLPVCRNFTVKIREGLQDFSKPIAVSLEYKLQDNL PIPVRRRRATEEFCKTCPILDPDMPSTVVLRVPYATGCGEEDTCRTDLKL TAELLNIKLPYIIGTLETVSLHITVISLLEPAFLSRVIVEIPKETALVRM PPTCQQVSTTNTIKYLHLECDTGNPLISDEKRVLELELDMKGVPANTKEL TFNVTAISVGDEQNNADNNVLIHVPLHTISDVRIVG-------------- -------------------------------------------------- KSSQDQLLYSKQNESKIEDLIVIHSYEVRNYGPSPVDAVQMEFQVPITLK AGGKTINFLKLYQPEVYLDNQPFNCKASKFPFYTDNISEGSGVSLDEPQS GALPDGSHRRRRSVNNQDGELSSLETLPINRTLFVNCSQPDTLCMTVTCA RVGPLLSSYTKAMVHLRMRANLRLL------------------------- -------DPIMDKKDVVLVSTNGVAIYQYLNNSLRPLSDNFNKTSVSTMF LGKIPAENIATWIIILAIIGGILIFMLLVLGLIK---------------- ----IEDEFQNDDEEL >Tbi -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -----------------------------------------------xx- -------------------------------------------------- -------------------------------------------------- ---------------------------------xxxxxxxx--------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- WLVVGAPRANSTLQNHRSIFQPGVTYQCDLSQDNKCSQIVLDPTGNGKKL AANGFSYKHKKDNAWIGGAIDVAEGRENSPLVVCGPRWKNNINVDYYLMN GICYWSSPSSISRPDRKAEEWLPLLGx----------------------- -------------------------------------------------- --------------------------------NKQGYTIKPKHPDENSTE VFYYAYGEAGISVHLV---------------------------------- ----------------------K----xxxELLIGAPGVFDWK------- -----------------GYSLGSGQFFQNASQTLYVSGAPRAADYKGK-- ----------------------------------------------VFIF DFPWNNDMPLKILLELEGYQMGEYFGATLCVVDLNNDGLDDLVVGAPLHS LGIHNSGLPTGDEGRVYVYINQEEGRMTEVASEIMGSSVHGARFGSSIAN IGDINLDGYA---------------------------------------- ----------------------DVAVGAYDSGHAVVLKSRPVVSLHAEIT ADVRKISFNASHFRVAVCISFFGKFARVIGVDLTLKVDPTYGRAQFYFDP GYSTNVYTYYVTLELGLPVCRNFTVKIKQGLQDFSKPIAVSLEYKLQDNI PIPVRRRRATE-----------DMPSTVVLRVPYATGCGEEDTCRTDLRL TAELLNIKLPYIIGTLETVSLHVTVISLLEPAFLSRVIVEIPRETALVRM PPTCQQVSTTNTIKYLRLECDTGNPLISDEKRVLELELDMKGVPANTKEL MFNITAISVGDEQNNADNNVLIHVPLHTISDVRIVGTNLLLPVLHPxxLC KVTQSEPLEExxxxAKTGEDSSGDKTxxDSSxxxxxxDSRxxxxxxxSRN ---------------------------VRNYGPSPVDAVQMEFQVPITIK AGGKTINFLKLYQPEVYLDNQPFNCKASKFPFYTDDISEGSGVSLDESQS GTLPDVSHRRRRSVNNQDGELSSLETLPINRTLFVNCSQPDTLCMTVTCV RVGPLLSSYTKAMVHLRMRANLRLL------------------------- -------DPIMDKKDVVLVSTNGVAIYQYLNNSLRPLSDNFNKTSVSTMF LGKIPAENIATWIIVLAIIGGILIFMLLVLGLIK---------------- ----IEDEFQNDDEEL >Tsi xxxxxxxxxxGxLxxxVQxPLSLDLATLGGIVRPLIDGCLCNNGIFVCCE CCVLLxxxxDTQVRGFQLGVSTRPHVVINVSLPLGGHQQGSRAERSPDGI AETRCTLRYKxxxxxxLFxxxxLRLEILFKCRDTAEPLIxxxxxxxxxxx xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx- -------------------------------------------------- --------------------------xxxxxxxxxxxxxTKAQNCDxxPx RSLVGLQEPAVEKKANSLQINSPTSQGQLVTFTC-------x-------- -----------------------------xxxxVYGEETRDVTFFSVTRN Vxxxx-------------------------xxxxxxRxxxxxPTPLPSSI PRTVFVVCDKVSSTRLTIPSLDSTRPLPSLLLRASDFLLQVTELELPTLx xxxxxxxxx----------------------------------------- PLVVGAPRANSTLQNHLSIFQPGVTYQCDLSQDNKCSQIVLDPTGNGKKL AANGFSYKHKKDNAWIGGAIDVVEGRENSPLVVCGPRWKNNINIDYYLMN GICYWSSPNSISRPDRKAEEWLPLLG------------------------ -------------------------------------------------- ------xSN-----------FDPSFKANLVPxDKQGYTIKPKHPDENSTE VFYYAYGEAGISVHLV---------------------------------- ----------------------K--xxxGSELLIGAPGVFDWK------- -----------------GYSLGSGQFFQNASQILYVSGAPRAANYKGK-- ----------------------------------------------VFIF DFPWNNDMPLKILLELEGYQMGEYFGATLCVVDLNNDGLDDLVVGAPLHS LGIHNSGLPTGDEGRVYVYINQEEGRMTEVASEIMGSSVHGARFGSSIAN IGDINLDGYADIAVGAPYENSGR--------------------------- ----------------------DVAVGAYDSGHAVVLKSRPVVSLHAEIT ADVRKISFNASHFRVAVCISFFGKFARVIGADLTMKVDPTYGRAQFYFDP GYSTNIYTYYVTLELGLPVCRNFTVKIKQGLQDFSKPIAVSLEYKLQDNL PIPVRRRRATEEFCKTCPILDPDMPSTVVLRVPYATGCGEEDTCRTDLKL TAELLNIKLPYIIGTLETVSLHITVISLLEPAFLSRVIVEIPKETALVRM PPTCQQVSTTNIIKYLHLECDTGNPLISDEKRVLELELDMKGVPANTKEL TFNVTAISVGDEQNNADNN------------------------------- -------------------------------------------------- ---------------------------VRNYGPSPIDAVQMEFQVPITLK AGGKTINFLKLYQPEVYLDNQPFNCKASKFPFYTDNISEGSGVSLDEPQS GALPDGSHRRRRSVNNQDGELSSLETLPINRTLFVNCSQPDTLCMTVTCA RVGPLLSSYTKAMVHLRMRANLRLL------------------------- -------DPIMDKKDVVLVSTNGVAIYQYLNNSLRPLTDNFNKTSVSTMF LGKIPAENIATWIIILAIIGGMLIFMLLVLGLIKxGFFRRDKKDELQLLK EKSLIEDEFQNDDEEL >Tcm -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -----------------------------------------x-------- -----------------------------xxxxVYGEETRDVTFFSVTRN Vxxxx-------------------------xxxxxxRxxxxxPTPLPSSI PRTVFVVCDxxxxxRLTIPSLDSTRPLPSLLLRASDLLLQVTELELPTLx xxxxxxxxx----------------------------------------- PLVVGAPRANSTLQNHLSIFQPGVTYQCDLSQDNKCSQIVLDPTGNGKKL AANGFSYKHKKDNAWIGGAIDVVEGRENSPLVVCGPRWKNNINIDYYLMN GICYWSSPNSISRPDRKAEEWLPLLGxRLS-------------------- ------------------------VRKGAGLNFAQIKTSSxSSSSSSSSS SSSSxSSSS-----------FDPSFKANLVPxDKQGYTIKPKHPDENSTE VFYYAYGEAGISVHLV---------------------------------- ----------------------KxxxxxGSELLIGAPGVFDWK------- -----------------GYSLGSGQFFQNASQTLYVSGAPRAANYKGK-- ----------------------------------------------VFIF DFPWNNDMPLKILLELEGYQMGEYFGATLCVVDLNNDGLDDLVVGAPLHS LGIHNSGLPTGDEGRVYVYINQEEGRMTEVASEIMGSSVHGARFGSSIAN IGDINLDGYADIAVGAPYENSGR--------------------------- ----------------------DVAVGAYDSGHAVVLKSRPVVSLHAEIT ADVRKISFNASHFRVAVCISFFGKFARVIGADLTMKVDPTYGRAQFYFDP GYSTNIYTYYVTLELGLPVCRNFTVKIKQGLQDFSKPIAVSLEYKLQDNL PIPVRRRRATEEFCKTCPILDPDMPSTVVLRVPYATGCGEEDTCRTDLKL TAELLNIKLPYIIGTLETVSLHITVISLLEPAFLSRVIVEIPKETALVRM PPTCQQVSTTNIIKYLHLECDTGNPLISDEKRVLELELDMKGVPANTKEL TFNVTAISVGDEQNNADNN------------------------------- -------------------------------------------------- ---------------------------VRNYGPSPIDAVQMEFQVPITLK AGGKTINFLKLYQPEVYLDNQPFNCKASKFPFYTDNISEGSGVSLDEPQS GALPDGSHRRRRSVNNQDGELSSLETLPINRTLFVNCSQPDTLCMTVTCA RVGPLLSSYTKAMVHLRMRANLRLL------------------------- -------DPIMDKKDVVLVSTNGVAIYQYLNNSLRPLTDNFNKTSVSTMF LGKIPAENIATWIIILAIIGGMLIFMLLVLGLIKxGFFRRDKKDELQLLK EKSLIEDEFQNDDEEL >Tps -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -----------------------------------------xxxxxxxxx xxxxxxxxxxxxxxxxxxxxxxxxxxxxxx-------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -LVVGAPRANSTLQNHLSIFQPGVTYQCDLSQDNKCSQIVLDPTGNGKKL AANGFSYKHKKDNAWIGGAIDVVEGRENSPLVVCGPRWKNNINIDYYLMN GICYWSSPNSISRPDRKAEEWLPLLG------------------------ -------------------------------------------------- ------SSN-----------FDPSFKANLVPxDKQGYTIKPKHPDENSTE VFYYAYGEAGISVHLV---------------------------------- ----------------------K--xxxGSELLIGAPGVFDWK------- -----------------GYSLGSGQFFQNASQTLYVSGAPRAANYKGK-- ------------------------PSCLIRWGIFEENWASPAYDVSVFIF DFPWNNDMPLKILLELEGYQMGEYFGATLCVVDLNNDGLDDLVVGAPLHS LGIHNSGLPTGDEGR---------GRMTEVAGEIMGSSVHGARFGSSIAN IGDINLDGYADIAVGAPYENSGR--------------------------- ----------------------DVAVGAYDSGHAVVLKSRPVVSLHAEIT ADVRKISFNASNFRVAVCISFFGKFARVIGADLTMKVDPTYGRAQFYFDP DYSTNIYTYYVTLELGLPVCRNFTVKIRQGLQDFSKPIAVSLEYKLQDNL PIPVRRRRATEEFCKTCPILDPDMPSTVVLRVPYATGCGEEDTCRTDLKL TAELLNIKLPYIIGTLETVSLHVTVISLLEPAFLSRVIVEIPKETALVRM PPTCQQVSTTNTIKYLHLECDTGNPLISDEKRVLELELDMKGVPANTKEL TFNVTAISVGDEQNNADNN------------------------------- -------------------------------------------------- ---------------------------VRNYGPSPVDAVQMEFQVPITLK AGGKTINFLKLYQPEVYLDNQPFNCKASKFSFYTDNISEGSGVSLDEPQS GTLPDGSHRRRRSVNNQDGELSCLETLPINRTLFVNCSQPDTLCMTVTCA RVGPLLSSYTKAMVHLRMRANLRLLVHPTEIRTSISPSSAVEQLNRTSAF ANYAIEADPIMDKKDVVLVSTNGVSIYQYLNNSLRPLSDNFNKTSVSTMF LGKIPAENIATWIIILAIIGGILIFMLLVLGLIKxGFFRRDKKDELQLLK EKSLIEDEFQNDDEEL