>Tge x---------------------------------------------x--- ---------------------------------------------xRLxx xxxxxxxxxxxxxxxFGQIRRNIVSCVVGVSPDKNVxxxCRVxxxSxxxx xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx x--------------------------RLVTPPTSWPRSSATITMRPYLP WLYTIQAFTLLVNFASGVPTQQHWNSSSILDDYDDLWPASYKMQQYGVVT NMTALLNPANHSHKLPPVPTPQQMELDTNKQFELLKINYSRLLSDIDGNL REDLRSGRHLPRIVDKALRLFDLKQVMEEVETSVMSKVSCTACKA----- -------------------------------------------------- -------------------------------------------------- xxxxxxxxxxGDACGDVYNPTHEWKVVFPPVQKPDVTPQKAPSPGAPTFK VLHLSDTHFDPYYQEGTNADCKEPLCCRLTNGPALSTHTAAGRWGDYR-- -------------------------------------------------- --------------------------xFPPPFVKNDFGISWLYDELDAQW RQWLPTSVSHTVRRGAFYSVL----------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------xxxxxxxxxxxxxxxxxxx xxxx----------------------x >Tms -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- --------------------------------------------MRPYLP WLYTIQTFTLLVNFASGVPTQQHWNSSSILDDYDDLWPASYKMQQYGVVT NMTALLNPANHSHKLPPVPTPQQMELDTNKQFELLKINYSRLLSDIDGDL REDLRSGRHLPRIVDKALRLFDLKQVMEEVETSVMSKVSCTACKA----- -------------------------------------------------- -------------------------------------------------- -----------DACGDVYNPTHEWKVVFPPVQKPDVTPQKAPSPGAPTFK VLHLSDTHFDPYYQEGTNADCKEPLCCRLTNGPALSPHTAAGRWGDYRKC DTPKRTVDHMLQHISSTHPDIDYILWTGDLPPHDVWNQTREENLMVLKET TAQMMQTFPGIPIFPALGNHESAPVNSFPPPFVKNDFGISWLYDELDAQW RQWLPTSVSHTVRRGAFYSVLVRPGFRIISLNMNYCNNKNWWLLLNSTDP AKELQWFIYELQSAEFNGEKVHVIGHIPPGHSDCLKVWSRNYFKIINR-- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- --------------------------- >Tce -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -----------------xxxxxxxxxxRLVTPPTSWPRSSITITMRPYLP WLYTIQTFTLLVNFASGVPTQQHWNSSSILDDYDDLWPASYKMQQYGVVT NMTALLNPANHSHKLPPVPTPQQMELDTNKQFELLKINYSRLLSDIDGDL REDLRSGRHLPRIVDKALRLFDLKQVMEEVETSVMSKVSCTACKA----- -------------------------------------------xxxxxxx xxxG---------------------------------------------- -----------DACGDVYNPTHEWKVVFPPVQKPDVTPQKAPSPGAPTFK VLHLSDTHFDPYYQEGTNADCKEPLCCRLTNGPALSPHTAAGRWGDYRKC DTPKRTVDHMLQHISSTHPDIDYILWTGDLPPHDVWNQTREENLMVLKET TAQMMQTFPGIPIFPALGNHESAPVNSFPPPFVKNDFGISWLYDELDAQW RQWLPTSVSHTVRRGAFYSVLVRPGFRIISLNMNYCNNKNWWLLLNSTDP AKELQWFIYELQSAEFNGEKVHVIGHIPPGHSDCLKVWSRNYFKIINRxx xxxxxxxxxxxxDHVLVAxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx xxxxxxxxxxxxSxxxxxxxxxxxxxxxxxHVAGTFPPTFFLPLxxxxxx xxxxxxxxxxxxxxxxxKPVTPQAxxxxxxxxQNEKxxxxxxxxxxx--- -------------------------------------------------- ----------AVVDHETWIMNLKEANLYDYPIWYKLYSARSAYQMPSLLP QDWDNLLNKMITDNALFDIYYKNYWKNSPVRPTCDSECKKRMICDLRSGR SHDRKELCQELESRIDGNTRTSWRTWIYNGLALS-------------Y-- -------------------------------------------------- ------xxxxxxxxxxxxxVxxxxxxx >Tsi -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ------------------------------------------MQQYGVVT NMTALLNPANHSHKLPPVPTPQQMELDTNKQFELLKINYSRLLSDIDGDL REDLRSGRHLPRIVDKALRLFDLKQVMEEVETSVMSKVSCTACKAGAGLL QHYIR--------------------------------------------- -------------------------------------------------- -----------DACGDVYNPTHEWKVVFPPVQKPDVTPQKAPSPGAPTFK VLHLSDTHFDPYYQEGTNADCKEPLCCRLTNGPALSPHTAAGRWGDYRKC DTPKRTVDHMLQHISSTHPDIDYILWTGDLPPHDVWNQTREENLMVLKET TAQMLQTFPGIPIFPALGNHESAPVNSFPPPFVKNDFGISWLYDELDAQW RQWLPTSVSHTVRRGAFYSVLVRPGFRIISLNMNYCNNKNWWLLLNSTDP AKELQWFIYELQSAEFNGEKVHVIGHIPPGHSDCLKVWSRNYYKIINR-- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- --------------------------- >Tcm -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ------------------------------------------MQQYGVVT NMTALLNPANHSHKLPPVPTPQQMELDTNKQFELLKINYSRLLSDIDGDL REDLRSGRHLPRIVDKALRLFDLKQVMEEVETSVMSKVSCTACKAGAGLL QHYIRVxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxDKxxx xxxG---------------------------------------------- -----------DACGDVYNPTHEWKVVFPPVQKPDVTPQKAPSPGAPTFK VLHLSDTHFDPYYQEGTNADCKEPLCCRLTNGPALSPHTAAGRWGDYRKC DTPKRTVDHMLQHISSTHPDIDYILWTGDLPPHDVWNQTREENLMVLKET TAQMLQTFPGIPIFPALGNHESAPVNSFPPPFVKNDFGISWLYDELDAQW RQWLPTSVSHTVRRGAFYSVLVRPGFRIISLNMNYCNNKNWWLLLNSTDP AKELQWFIYELQSAEFNGEKVHVIGHIPPGHSDCLKVWSRNYYKIINR-- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- --------------------------- >Tps -------------------------------------------------- ----------------------------------xxxxxxxxxxxx---- -------------------------------------------------- -------------------------------------------------- xxxxxxxxxxxxxxxxxx----------LVTPPTSWPRSSATITMRPYLP WLYTIQVFTLLVNFASGVPTQQHWNSSSILDDYDDLWPASYKMQQYGVVT NMTALLNPANHSHKLPPVPTPQQMELDTNKQFELLKINYSRLLSDIDGDL REDLRSGRHLPRIVDKALRLFDLKQVMEEVETSVMSKVSCTACKAGAGLL QHYIRVxxxxxxxxxxxxxxxxxSWSxxxxxxxxxxxxxxxxxGxDKxxx xxxG---------------------------------------------- -----------DACGDVYNPTHEWKVVFPPVQKPDVTPQKAPSPGAPTFK VLHLSDTHFDPYYQEGTNADCKEPLCCRLTNGPALSPHTAAGRWGDYRKC DTPKRTVDHMLQHISSTHPDIDYILWTGDLPPHDVWNQTREENLMVLKET TAQMLQTFPGIPIFPALGNHESAPVNSFPPPFVKNDFGISWLYDELDAQW RQWLPTSVSHTVRRGAFYSVLVRPGFRIISLNMNYCNNKNWWLLLNSTDP AKELQWFIYELQSAEFNGEKVHVIGHIPPGHSDCLKVWSRNYYKIINR-- -------------------------------------------------- -------------------------------------------------- ----------------------------------------------YEST IIAQFFGHTHFDEFELFYDTTDVGRVTSIAYVGPSVTPxNDLxxGYRIxx xxGDHKESTRAVVDHETWIMNLKEANLYDYPIWYKLYSARSAYQMPSLLP QDWDNLLNKMITDNTLFDIYYKNYWKNSPVRPTCDSECKKRMICDLRSGR SHDRKELCQELESRIDGNTRTSWRTWIYNGLALS---------------- ---------------xxxxxxxxxxxxxxxxx------------------ ---xxxx-------------------x >Tdi ----------------------------------------------x--- ---------------------------------xxxxxxxxxxxxx---- -------------------------------------------------- -------------------------------------------------- xxxxxxxxxxxxxxxxxYxxxxxxxxxRLVTPPTSWPRSSATITMRPYLP WLYTIQVFTLLVNFASGVPTQQHWNSSSILDDYDDLWPASYKMQQYGVVT NMTALLNPANHSHKLPPVPTPQQMELDTNKQFELLKINYSRLLSDIDGDL REDLRSGRHLPRIVDKALRLFDLKQVMEEVETSVMSKVSCTACKAGAGLL QHYIRVxxxxxxxxxxxxxxxxxSWSxxxxxxxxxxxxxxxxxGxDKIxx xxxG---------------------------------------------- -----------DACGDVYNPTHEWKVVFPPVQKPDVTPQKAPSPGAPTFK VLHLSDTHFDPYYQEGTNADCKEPLCCRLTNGPALSPHTAAGRWGDYRKC DTPKRTVDHMLQHISSTHPDIDYILWTGDLPPHDVWNQTREENLMVLKET TAQMLQTFPGIPIFPALGNHESAPVNSFPPPFVKNDFGISWLYDELDAQW RQWLPTSVSHTVRRGAFYSVLVRPGFRIISLNMNYCNNKNWWLLLNSTDP AKELQWFIYELQSAEFNGEKVHVIGHIPPGHSDCLKVWSRNYYKIINR-- -------------------------------------------------- -------------------------------------------------- ----------------------------------------------YEST IIAQFFGHTHFDEFELFYDTTDVGRVTSIAYVGPSVTPxNDLxxGYRIxx xxGDHKESTRAVVDHETWIMNLKEANLYDYPIWYKLYSARSAYQMPSLLP QDWDNLLNKMITDNTLFDIYYKNYWKNSPVRPTCDSECKKRMICDLRSGR SHDRKELCQELESRIDGNTRTSWRTWIYNGLALS-------------Yxx xxxxxxxxxxxxxxxx---------------------------------- --------------------------- >Tbi ----------------------------------------------xxxx xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx--------------- -------------------------------------------------- -------------------------------------------------- ----------------------------LVTPPTSWPRSSATITMRPYLP WLYSIQAFTLLVNFASGVPTQQHWNSSSILDDYDDLWPASYKMQQYGVVT NMTALLNPANHSHKLPPVPTPQQMELDTNKQFELLKINYSRLLSDIDGNL REDLRSGRHLPRIVDKALRLFDLKQVMEEVETSVMSKVSCTACKAGAGLL QHYIR--------------------------------------------- ---xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx------------ ----------VNACGDVYNPTHEWKVVFPPVQKPDVTPQKAPSPGAPTFK VLHLSDTHFDPYYQEGTNADCKEPLCCRLTNGPALSTHTAAGRWGDYRKC DTPKRTVDHMLQHISSTHPDIDYILWTGDLPPHDVWNQTREENLMVLKET TAQMLQTFPGIPIFPALGNHESAPVNSFPPPFVKNDFGISWLYDELDAQW RQWLPTSVSHTVRRGAFYSVL----------------------------- ------------SAEFNGEKVHVIGHIPPGHSDCLKVWSRNYYKIINR-- -------------------------------------------------- -------------------------------------------------- ----------------------------------------------YEST IIAQFFGHTHYDEFELFYDTTDMGRVTSIAYVGPSVTPYYDLNPGYRIYY IDGDHKESTRAVVDHETWVMNLKEANLYDYPIWYKLYSTRSAYQMPSLLP QDWDNLLNKMVTDNALFDIYYKNYWKNSPVRPTCDSECKKRMICDLRSGR SHDRKELCQELESRIDGNTRTSWRTWIYNGLALS---------Ixxxx-- -------------------------------------------------- --------------------------x >Tte xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx--- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ----------------------------LVTPPTSWPRSSATITMRPYLP WLYSIQAFTLLVNFASGVPTQQHWNSSSILDDYDDLWPASYKMQQYGVVT NMTALLNPANHSHKLPPVPTPQQMELDTNKQFELLKINYSRLLSDIDGNL REDLRSGRHLPRIVDKALRLFDLKQVMEEVETSVMSKVSCTACKA----- -------------------------------------------------- -------------------------------------------------- -----------DACGDVYNPTHEWKVVFPPVQKPDVTPQKAPSPGAPTFK VLHLSDTHFDPYYQEGTNADCKEPLCCRLTNGPALSTHTAAGRWGDYRKC DTPKRTVDHMLQHISSTHPDIDYILWTGDLPPHDVWNQTREENLMVLKET TAQMLQTFPGIPIFPALGNHESAPVNSFPPPFVKNDFGISWLYDELDAQW RQWLPTSVSHTVRRGAFYSVL----------------------------- ------------SAEFNGEKVHVIGHIPPGHSDCLKVWSRNYYKIINR-- -------------------------------------------------- -------------------------------------------------- ----------------------------------------------YEST IIAQFFGHTHYDEFELFYDTTDMGRVTSIAYVGPSVTPxxxxxxGYRIxx xxGDHKESTRAVVDHETWVMNLKEANLYDYPIWYKLYSTRSAYQMPSLLP QDWDNLLNKMVTDNALFDIYYKNYWKNSPVRPTCDSECKKRMICDLRSGR SHDRKELCQELESRIDGNTRTSWRTWIYNGLALSxxxxxxxxx------- -------------------------------------------------- --------------------------- >Tpa -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- --------------------------------------------MRPYLP WLYTIQAFTLLVNFASGVPTQQHWNSSSILDDYDDLWPASYKMQQYGVVT NMTALLNPANHSHKLPPIPTPQQMELDTNKQFELLKINYSRLLSDIDGNL REDLRSGRHLPRIVDKALRLFDLKQVMEEVETSVMSKVSCTACKAGAGLL QHYIR--------------------------------------------- ---xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx xxxxxxxxxxxDACGDVYNPTHEWKVVFPPVQKPDVTPQKAPSPGAPTFK VLHLSDTHFDPYYQEGTNADCKEPLCCRLTNGPALSTHTAAGRWGDYRKC DTPKRTVDHMLQHISSTHP------------------------------- -------------------------------------------------- -------------------------------------------------- --------------------------------xCL--------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ---------------------------