>Tge -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -xxxxxGRGINIHFRRKExxxxxxxxxxxxxxxxxxxxQPIVVRSPTVxx xEELPYSVMVxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx xxxxxxxxx-------------xKATEMVVTWSTVNDTSHMVEGSWVEYG LDVLNLTANSSYSGTTSFRNQYIHRVKLTDLEPGSVYVYHCGSELGWSPV FWFKTRPAGQSWSPMLAVYGDLGNSYAESLTLLQKEAQRGLYDAFIHAGD FA---------VGDEFLRQIESIAGYVPYMTCPGNHEQANNFSDYRNRFS MPGDTEGLWYSFDVGPIHFISISTEVYYFLEYGFEL-------------x xxxIATLAENR--------------------------------------- -ALRPWIIVYGHRPMYCSNENTDDCTTNQTQTRTGFMELLGKGLEDLLYD YGVDLEIWAHEHSYERLWPIYNYQVYNGSLNSPYSNPEAPVHVVTGSAGC SEFHDPFKSEQPYWSAFRSSNYGYNRLKVFNSTHLYME----YVSVEHHG VSI----------------------------------------------- -------------------------------------------------- -------------------------------------------------- ---------------------------------------AYHCGSEKGWS PVFWFKTRPPGQSWSPALAVYGDLGYHNARSLPLLQNEVQRGFYDAVIHA GDFAYDMNDEEGKVGDKFL------------------------RQIESMA GYIPYMTCPGNHEANNNFSDYRNRFSMPGDTEGLWYSFDVGPIHFISIST EVYYFLEYGFELLARQFNWLKEDLK------------------------- ------KATKPSNRALRPWIIVYGHRPMYCSNKNTDYCTMNQTRTRIGTP DIMKLVLSNLHQKGHFWQLG--------------------NDGLEDMFYK HGVDLEIWAHEHSYERLWPIYNYQIYNGSLMEPYRNPGAPVHVITGSAGC DEKHDPFKSEQPYWSAFRSNDYGYTRLKVFNSTHLYMEYVSVEHHG---- -------------------------------------------------- -------------------------------------------------K GK--------------------xxxxxxxxxxxxxxxxxxxxxxxxxxxx xxxxx--------------------------------------------- ---------------------------- >Tbi x------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -----------------------GxxxxSxxxxxxxxxxxxxxxxxxxxx x------------------------------------------------- -------------------------------------------------- -----------------------KATEMIVTWSTVNDTRHMVEGSWVEYG LDVLNLTANSSYSGTTSFRNQYIHRVKLTDLEPGSVYVYHCGSELGWSPV FWFKTRPAGQSWSPMLAVYGDLGNSYAESLTILQKEAQRGLYDAFIHAGD FA---------VGDEFLRQIESIAGYVPYMTCPGNHEQANNFSDYRNRFS MPGNTEGLWYSFDVGPIHFISISTEVYYFLEYGFELLTRQFNWLKDDLK- ---IATLAENR--------------------------------------- -ALRPWIVVYGHRPMYCSNENTDDCTTNQTQTRTGFMELLGKGLEDLLYD YGVDLEIWAHEHSYERLWPIYNYQVYNGSLDSPYSNPEAPVHVITGSAGC SEFHDPFKLEQPYWSAFRSADYGYTRLKVFNSTHLYME----YVSIEHHG VSI----------------------------------------------- -------------------------------------------------- -------------------------------------------------- ---------------------------------------AYHCGSEKGWS PVFWFKTRPPGQSWSPALAVYGDLGYHNARSLPHLQNEVQRGFYDAVIHA GDFAYDMNDEEGNVGDKFL------------------------RQIESMA GYIPYMTCPGNHEANNNFSDYRNRFSMPGNTEGLWYSFDVGPIHFISIST EVYYFLEYGFELLARQFNWLKDDLK------------------------- ------KATKPSNRALRPWIIVYGHRPMYCSNKNTDDCTMNQTRTRIGTP DIMKLVLSNLHQKGLFWQLGxLLDLLSRINxYV-------SDGLEDMFYK HGVDLEIWAHEHSYERLWPIYNYQIYNGSLMEPYRNPGAPVHVITGSAGC DEKHDPFKSEQPYWSAFRSNDYGYTRLKVLNSTHLYMEYVSVEHHG---- -------------------------------------------------- -------------------------------------------------K GKxxxxxxxxxxxxxxxxxxxx---------------------------- -------------------------------------------------- ---------------------------- >Tms x------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------xxxxxxxxxxxxxxxxxxxxxxx-------------------- ---------------------------------------AYHCGSEKGWS PVFWFKTRPPGQSWSPALAVYGDLGYHNARSLPHLQNEVQRGFYDAVIHA GDFAYDMNDEEGNVGDKFL------------------------RQIESMA GYVPYMTCPGNHEANNNFSDYRNRFSMPGNTEGLWYSFDVGPIHFISIST EVYYFLEYGFELLTRQFNWLKEDLK------------------------- ------KATKSSNRALRPWIIVYGHRPMYCSNKNTDDCTMNQTRTRIGTP DIM-------------------------------------NDGLEDMFYN HGVDLEIWAHEHSYERLWPIYNYQIYNGSLMEPYRNPGAPVHVITGSAGC DEKHDPFKSKQPYWSAFRSADYGYSRLKVFNSTHLYMEYVSVEHHGxxxx xxxxTNSQxxxxxxxxTR-------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ---------------------------- >Tce xx------------------------------------------------ -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ---------------xxxxxxxxxxxxxSGRRGVARxxxxxxxxxxxxxx -------------------------------------------------- -------------------------------------------------- --------xxxxxxxxxxxxxxDKATEMVVTWSTVNDTRHIVEGSWVEYG LDVLNLTANSSYSGTTSFRDQYIHRVKLTDLEPGSVYVYHCGSEPGWSTV FWFKTQPAGQSWSPML---------------------------------- -x-----xxxxVGDEFLRQIESIAGYVPYMTCPGNHEQANNFSDYRNRFS MPGNTEGLWYSFDVGPIHFISISTEVYYFLEYGFELLTRQFNWLKEDLK- ---IAVLAENR--------------------------------------- -ALRPWIIVYGHRPMYCSNENTDDCTTNQTQTRTGFMELLGKGLEDMFYN HGVDLEIWAHEHSYERLWPIYNYQIYNGSLMEPYRNPGAPVHVITGSAGC SEFHDPFKSEQPYWSAFRSADYGYNRLKVFNSTHLYME----YVSVEHHG VSIGRSQCTNSQYRSVIRTFTSSSTTIKNYLLITRSLVLQSGNGSRSVAS TPVSLATGVAQSLARLSFRPRESLSHSHACQSGHRSRSVTHTLVSLPEMK ILIVNVLQFLFFRHACSDSFQPDQIHISYxDKATEMVITWSTGRRTEFSC VEYGLGNLELIESAFKMTPFRKQYIHRVKLTNLKPNxxxAYHCGSEKGWS PVFWFKTRPPGQSWSPALAVYGDLGYHNARSLPHLQNEVQRGFYDAVIHA GDFAYDMNDEEGNVGDKFL------------------------RQIESMA GYVPYMTCPGNHEANNNFSDYRNRFSMPGNTEGLWYSFDVGPIHFISIST EVYYFLEYGFELLTRQFNWLKEDLKVCYLLIYIDVMTPQTLKLLRCNNFT SKTLPQKATKSSNRALRPWIIVYGHRPMYCSNKNTDDCTMNQTRTRIGTP DIMKLLI-------------------------xxxxxxxxSDGLEDMFYN HGVDLEIWAHEHSYERLWPIYNYQIYNGSLMEPYRNPGAPVHVITGSAGC DEKHDPFKSKQPYWSAFRSADYGYSRLKVFNSTHLYMEYVSVEHHGxxxx xxxxTxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxPNTPPSVHSCRRNG LVQVSVSGPPVSKHSLRSTLQPISKRLALLRSTAEDGxxxxxxxxxxxxx -------------------------------------------------- ----xxxxxxxxxxxxxxxxxxxxxPTPLGKTEDVTQVGFPHCRLKENSL CYSSPMASLVLTDSSQLTTVDIFKKLPD >Tcm x------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ----------------xxxxxxxGGxxxSGRRGVARxxxRYDVPxxxxxx x------------------------------------------------- -------------------------------------------------x xxxxxxxxx-------------DKATEMVVTWSTVNDTRPMVEGSWVEYG LDVLNLTANSSYSGTTSFRNQFIHRVKLTDLEPGSVYVYHCGSELGWSSV FWFKTRPEGQSWSPMLAVYGDLGNSYAESLTLLQKEAHIGLYDAFIHAGD FA---------VGDEFLRQIESIAGYVPYMTCPGNHEQANNFSDYRNRFS MPGNTEGLWYSFDVGPIHFISISTEVYYFLEYGFELLTRQFNWLKEDLK- ---IAILAENRxxxxxxxxxxxxxxxxxxxxxDDCTTNQTQTRTGFMELL GALRPWIIVYGHRPMYCSNENTDDCTTNQTQTRTGFMELLGKGLEDLFYD YGVDLEIWAHEHSYERLWPIYDYQIYNGSLDSPYSNLEAPVHVITGSAGC SEFHDPFKSEQPYWSAFRSADYGYNRLKVFNSSHLYMExxx-xxx----- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ---------------------------------------AYHCGSEKGWS PVFWFKTRPPGHSWSPALAVYGDLGYHNARSLPHLQNEVQRGFYDAVIHA GDFAYDMNDEEGNVGDKFL------------------------RQIESMA GYIPYMTCPGNHEANNNFSDYRNRFSMPGNTEGLWYSFDVGPIHFISIST EVYYFLEYGFELLTRQFNWLKEDLK------------------------- ------KATKPSNRALRPWIIVYGHRPMYCSNKNIDDCTMNQTRTRIGTP DIM-------------------------------------NDGLEDMFYN HGVDLEIWAHEHSYERLWPIYNYQIYNGSFREPYRNPGAPVHVITGSAGC DEKHDPFKSKQPYWSAFRSVDYGYNRLKVFNSSHLYMEYVSVEHHGxxxx xxxxTNSQxxxxxxxxTRS------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ---------------------------- >Tsi MxxxVxxxKVLKPPxxxxVRNLAxxxxxKHLKDExxxxxxxGISxxASLV LRDSSQLxxFKxYxTKxxxxxxxxxICKNMCxxxxTSESQNLASDN---- -------------------------------------------------- -----------------------Qxxxxxxxxxxxxxxxxxxxxxxxxxx xxxxIPxxxxxxxxxxxxxxxxxGGxxxSSRRGVARxxxRYAVPxxxxxx x------------------------------------------------- -------------------------------------------------- -----------------------KATEMVVTWSTVNDTRPMVEGSWVEYG LDVLNLTANSSYSGTTSFRDQYIHRVKLTDLEPGSVYVYHCGSELGWSTV FWFKTRPEGQSWSPMLAVYGDLGNSYAESLTLLQKEAQRGLYDAFIHAGD FAYDLDSEEGRVGDEFLGQIESIAGYVPYMTCPGNHEQANNFSDYRNRFS MPGNTEGLWYSFDVGPIHFISISTEVYYFLEYGFELLTRQFSWLKEDLK- ---IAILAENR--------------------------------------- -ALRPWIIVYGHRPMYCSNENTDDCTSNQTQTRTGFMELLGKGLEDLFYD YGVDLEIWAHEHSYERLWPIYNYQIYNGSLDSPYSNPEAPVHVITGSAGC SEFHDPFKSKQPYWSAFRSADYGYNRLKVFNSTHLYMExxxxxxx----- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ---------------------------------------AYHCGSEKGWS PVFWFKTRPPGHSWSPALAVYGDLGYHNARSLPHLQNEVQRGFYDAVIHA GDFAYDMNDEEGNVGDKFL------------------------RQIESMA GYIPYMTCPGNHEANNNFSDYRNRFSMPGNTEGLWYSFDVGPIHFISIST EVYYFLEYGFELLTRQFNWLKEDLK------------------------- ------KATKPSNRALRPWIIVYGHRPMYCSNKNIDDCTMNQTRTRIGTP DIM-------------------------------------NDGLEDMFYN HGVDLEIWAHEHSYERLWPIYNYQIYNGSLREPYRNPGAPVHVITGSAGC DEKHDPFKSKQPYWSAFRSVDYGYNRLKVFNSTHLYMEYVSVEHHRxxxx xxxxTNTQxxxxxxxxTRS------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ---------------------------- >Tpa x------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------x xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxAYHCGSEKGWS PVFWFKTRPPGQSWSPALAVYGDLGYHNARSLPLLQNEVQRGFYDAVIHA GDFAYDMNDEEGKVGDKFL------------------------RQIESMA GYIPYMTCPGNHEANNNFSDYRNRFSMPGDTEGLWYSFDVGPIHFISIST EVYYFLEYGFELLARQFNWLKEDLK------------------------- ------KATKPSNRALRPWIIVYGHRPMYCSNKNTDDCTMNQTRTRIGTP DIM-------------------------------------NDGLEDMFYK HGVDLEIWAHEHSYERLWPIYNYQIYNGSLMEPYRNPGAPVHVITGSAGC DEKHDPFKSEQPYWSAFRSNDYGYTRLKVFNSTHLYMEYVSVEHHG---- -------------------------------------------------- -------------------------------------------------x xx--------------------xxxxxxxxxxxxxxxxxxxxxxxxxxxx xxxxx--------------------------------------------- ---------------------------- >Tte M------------------------------------------------- ---------------------------------------------xxxxx xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx xxxxxxxxxxxxxxxxxxxxxxxx-------------------------- -------------------------------------------------- --xx---------------------------------------------- -------------------------------------------------- ----------------------DKATEMIVTWSTVNDTRHMVEGSWVEYG LDVLNLTANSSYSGTTSFRNQYIHRVKLTDLEPGSVYVYHCGSELGWSPV FWFKTRPAGQSWSPMLAVYGDLGNSYAESLTILQKEAQRGLYDAFIHAGD FA---------VGDEFLRQIESIAGYVPYMTCPGNHEQANNFSDYRNRFS MPGNTEGLWYSFDVGPIHFISISTEVYYFLEYGFELLTRQFNWLKDDLK- ---IATLAENR--------------------------------------- -ALRPWIIVYGHRPMYCSNENTDDCTTNQTQTRTGFMELLGKGLEDLLYD YGVDLEIWAHEHSYERLWPIYNYQVYNGSLDSPYSNPEAPVHVITGSAGC SEFYDPFKSEQPYWSAFRSADYGYTRLKVFNSTHLYME----YVSVEHHG VSI----------------------------------------------- -------------------------------------------------- -------------------------------------------------- ---------------------------------------AYHCGSEKGWS PVFWFKTRPPGQSWSPALAVYGDLGYHNARSLPHLQNEVQRGFYDAVIHA GDFAYDMNDEEGNVGDKFLxxxxxxxxxxxxxxxxxxxxxxxx------- ---------------------------------------IGPIHFISIST EVYYFLEYGFELLARQFNWLKDDLK------------------------- ------KATKPSNRALRPWIIVYGHRPMYCSNKNTDDCTMNQTRTRIGTP DIMKLVLSNLHQKGLFWQLGKLLDLLSRINx----------DGLEDMFYK HGVDLEIWAHEHSYERLWPIYNYQIYNGSLMEPYRNPGAPVHVITGSAGC DEKHDPFKSEQPYWSAFRSNDYGYTRLKVLNSTHLYMEYVSVEHHG---- -------------------------------------------------- -------------------------------------------------x xx------------------------------------------------ -------------------------------------------------- ----------------------------