>Tge x------------------------------------------------- ----------------------------------------------xxxx xxxGQxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxIxxxxxxxxxxxxxL LKLKAAPGLVAxxxxxxxxxxxxxxxxxxx---------x---------- ---------------------------xxxxxxxxxxx------------ ---RLKKWGMDSYLYAPKDDYKHRAYWRELYTVEEAEHLTGLISSAVEHG ITFYYALSPGLDITYSSAKEVAALKRKLEQVSRFGCTAFALLFDDIEPEM SEADKEVFQSFAHAQVSVSNEVFQHLGQPRFMLCPTQYCAARATPNVQNS EYLNTLGAKLAPEIDIMWT------------------------------- -----------------------------------------------GPK VISRILTVESIEEITDVLRRPPVIWDNIHANDYDQKRVFLGPYSGRSPDL IPKLRGVLTNPNCEYGANFVAIHTLAQWSRCNVDGKRDPTINDTVSADIK LETETEDGGVGEDVPSTLSPNMYHPRQALRNAINEWLPEFFRPRAVWGPI AKPQQVVAAAVPIPIIPSVNTCMSLTTTTTSCSSATLPLINSNQLQALAE VCSSVTTSIS---------------------------------xxxxxxx xxxxx--------------------------------------------- ------------------------xCEKALTHEDLALLCDLFYLPFEHGG QGIQLLQEFNWLKSNAHLVTQANKKGKESPTEPEVTEWFERATRLEEISK AVNLLFQHLTFVPNRELLYDLYPYMWDMRGVISLLNSYIKWLG------- -----------------------------------------FSKGWKETF MSGEQEPWVFRGGLTADLQxxxxxxSGNDLFVYKPPDVPSSxxxTI---- ------------------------------------RPxLPMDESNVYDV -------------------------LVGGFLSLSGEFCFVVEDEVGLVGY ALAALDAKQFHKKLELAWLPDMCDKYPSPNKTADQGMSRPE--------- -------------------------------------------------- -------------ELMSWFHTFKGDVPESIHSQHPSVMCCSLLSTVLDQS VAKRMITCLLAALRANGQFP------------------------------ -------------------------------------------------- ----------------------------xxxxxxxxxxxxxxxxxxxxxx xxxxx >Tms -------------------------------------------------- -------------------------------------------------- -------------------------------------xxxxxxxxxxxxx xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx------------------- -------------------------------------------------- -------------------------------------xxxxxxxxxxxxx xxxKLKKWGMDSYLYAPKDDYKHRAYWRELYTVEEAEHLTGLISSAVEHG ITFYYALSPGLDITYSSAKEVAALKRKLEQVSRFGCTAFALLFDDIEPEM SEADKEVFQSFAHAQVSVSNEVFQHLGQPRFMLCPTQYCAARATPNVQNS EYLNTLGAKLAPEIDIMWT------------------------------- -----------------------------------------------GPK VISRILTVESIEEITDVLRRPPVIWDNIHANDYDQKRVFLGPYSGRSPDL IPKLRGVLTNPNCEYGANFVAIHTLAQWSRCNVDGKRDPSINDTVSADIK LETETEDGGVGEDVPSTLSPNMYHPRQALRNAINEWLPEFFRPRVVWGPI AKPQQVVAAAVPIPIIPSVNTCMSLTTTTTSCSSATLPLINSNQLQALAE VCSSVTTSISEATLLSVTAINxxxLQPVSGAxMNSLISETKVx------- -------------------------------------------------- -------------------------CEKALTHEDLALLCDLFYLPFEHGG QGIQLLQEFNWLKSNAHL----------------xTEWFERATRLEEISK AVNLLFQHLTFVPNRELLYDLYPYMWDMRGVISLLNSYIKWLG------- -----------------------------------------FSKGWKETF MSGEQEPWVFRGGLTADLQxxxxxxSGNDLFVYKPPDVPSSxxxTI---- ------------------------------------RP------------ -------------------------LVGGFLSLSGEFCFVVEDEVGLVGY ALAALDAKQFHKKLELDWLPDMCDKYPSPNKTADQGMSRP---------- -------------------------------------------------- -------------xLMSWFHTFKGDVPESIHSQHPSVMCCSLLSTVLDQS VAKRMITCLLAALRANG--------------------------------- -------------------------------------------------- -------------------------------------------------- ----- >Tbi xxxxxxxxxxxxxxxxxxxxxxxxx------------------------- ------------------------------------xxxxxxxxxxx--- -------------------------------------------------- ---------------------------------x---------------- -------------xxxxxxxxxxxxxxxxx---------x---------- ---------------------------xxxxxxxxxxx------------ ---RLKKWGMDSYLYAPKDDYKHRAYWRELYTVEEAEHLTGLISSAVEHG ITFYYALSPGLDITYSSAKEVAALKRKLEQVSRFGCTAFALLFDDIEPEM SEADKEVFQSFAHAQVSVSNEVFQHLGQPRFMLCPTQYCAARATPNVQNS EYLNTLGAKLAPEIDIMWT------------------------------- -----------------------------------------------GPK VISRILTVESIEEITDVLRRPPVIWDNIHANDYDQKRVFLGPYSGRSPDL IPKLRGVLTNPNCEYGANFVAIHTLAQWSRCNVDGKRDPTINDTVSADIK LETETEDGGVGEDVPSTLSPNMYHPRQALRNAINEWLPEFFRPRAVWGPI AKPQQVVAAAVPIPIIPSVNTCMSLTTTTTSCSSATLPLINSNQLQALAE VCSSVTxxxxxxxxx----------------------------------- -------------------------------------------------- -------------------------CEKALTHEDLALLCDLFYLPFEHGG QGIQLLQEFNWLKSNAHLVTQANKKGKESPTEPEVTEWFERATRLEEISK AVNLLFQHLTFVPNRELLYDLYPYMWDMRGVISLLNSYIKWLG------- -----------------------------------------FSKGWKETF MSGEQEPWVFRGGLTADLQxxxxxxxxxxxxxxxPPxxxxx--------- ---------------------------------------LPMDESNVYDV CRHTCMDGMDGTECFSDQPNLVGDKLVGGFLSLSGEFCFVVEDEVGLVGY ALAALDAKQFHKKLELDWLPDMCDKYPSPNKTADQGMSRPExCLLLYPRP YALSTMSFKSHLKHKMLVHFLIKEVDVCEAGFLSQIESRTKTNITHKFRI FIDSNHILVKYAKELMSWFHTFKGDVPESIHSQHPSVMCCSLLSTVLDQS VAKRMITCLLAALRANGQFL-xxxxxxxxxxxxxxxxxxx---------- --------------------------xx---------------------- -------------------------------------------------- ----- >Tte x------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ---------------------------------------xxxxxxxxxx- ----xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx------------ ---RLKKWGMDSYLYAPKDDYKHRAYWRELYTVEEAEHLTGLISSAVEHG ITFYYALSPGLDITYSSAKEVAALKRKLEQVSRFGCTAFALLFDDIEPEM SEADKEVFQSFAHAQVSVSNEVFQHLGQPRFMLCPTQYCAARATPNVQNS EYLNTLGAKLAPEIDIMWT------------------------------- -----------------------------------------------GPK VISRILTVESIEEITDVLRRPPVIWDNIHANDYDQKRVFLGPYSGRSPDL IPKLRGVLTNPNCEYGANFVAIHTLAQWSRCNVDGKRDPTINDTVSADIK LETETEDGGVGEDVPSTLSPNMYHPRQALRNAINEWLPEFFRPRAVWGPI AKPQQVVAAAVPIPIIPSVNTCMSLTTTTTSCSSATLPLINSNQLQALAE VCSSVTTSISEATLx----------------------------------- -------------------------------------------------- -------------------------CEKALTHEDLALLCDLFYLPFEHGG QGIQLLQEFNWLKSNAHLVTQANKKGKESPTEPEVTEWFERATRLEEISK AVNLLFQHLTFVPNRELLYDLYPYMWDMRGVISLLNSYIKWLG------- -----------------------------------------FSKGWKETF MSGEQEPWVFRGGLTADLQxxxxxxSGNDLFVYKPPDVPSSxxxTI---- ------------------------------------RPxLPMDESNVYDV -------------------------LVGGFLSLSGEFCFVVEDEVGLVGY ALAALDAKQFHKKLELDWLPDMCDKYPSPNKTADQGMSRPEVCLLLYPRP YALSTMSFKSHLKHKMLVHFLIKEVDVCEAGFLSQIESRTETNITHKFRI FIDSNHILVKYAKELMSWFHTFKGDVPESIHSQHPSVMCCSLLSTVLDQS VAKRMITCLLAALRANGQFS-xxxxxxxxxxxxxxxxxxx---------- --------------------------xx---------------------- -------------------------------------------------- ----- >Tdi x------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ---------------------------------xxxxxxxxxxxxxxxxx xxxxxxxxxxxx-xxxxxxxxxxxxxxxxxxxxxxxxxxx---------- -------------------------------------------------- ----LKKWGMDSYLYAPKDDYKHRAYWRELYTVEEAEHLTGLISSAVEHG ITFYYALSPGLDITYSSAKEVAALKRKLEQVSRFGCTAFALLFDDIEPEM SEADKEVFQSFAHAQVSVSNEVFQHLGQPRFMLCPTQYCAARATPNVQNS EYLNTLGAKLAPEIDIMWT------------------------------- -----------------------------------------------GAK VISRILTVESIEEITDVLRRPPVIWDNIHANDYDQKRVFLGPYSGRSPDL IPKLRGVLTNPNCEYGANFVAIHTLAQWSRCNVDGKRDPSINDTVSADIK LETETEDGGVGEDVPSTLSPNMYHPRQALRNAINEWLPEFFRPRAVWGPI AKPQQVVAAAVPIPIIPSVNTCMSLTTTTTSCSSATLPLINSNQLQALAE VCSSVTTSISEATxxx----------PVSGAVMNSLISETKxx------- -------------------------------------------------- -------------------------CEKALTHEDLALLCDLFYLPFEHGG QGIQLLQEFNWLKSNAHLVTQANKKGKESPTEPEVTEWFERATRLEEISK AVNLLFQHLTFVPNRELLYDLYPYMWDMRGVISLLNSYIKWLG------- -----------------------------------------FSKGWKETF MSGEQEPWVFRGGLTADLQxxxxxxSGNDLFVYKPPDVPSS-xxxx---- ------------------------------------RPxLPMDESNVYDV CRHTCMDGMDGTECFSDQPNLVGDKLVGGFLSLSGEFCFVVEDEVGLVGY ALAALDAKQFHKKLELDWLPDMCDKYPSPNKTADQGMSRPEVWLLLYPQP YALSTMSFKSLLRHKIx--------------------------------- --------------LMSWFHTFKGDVPESIHSQHPSVMCCSLLSTVLDQS VAKRMITCLLAALRANGQFPxxxxxxxxxxx------------------- ---------------------------xxxxxx----------------- ---------------xxxx------------------------------- ----x >Tpa x------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ----------------------------------------------xxxx xxxxxx-------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -----------------------------------------------GPK VISRILTVESIEEITDVLRRPPVIWDNIHANDYDQKRVFLGPYSGRSPDL IPKLRGVLTNPNCEYGANFVAIHTLAQWSRCNVDGKRDPTINDTVSADIK LETETEDGGVGEDVPSTLSPNMYHPRQALRNAINEWLPEFFRPRAVWGPI AKPQQVVAAAVPIPIIPSVNTCMSLTTTTTSCSSATLPLINSNQLQALAE VCSSVTTSISEATLx----------------------------------- -------------------------------------------------- -------------------------CEKALTHEDLALLCDLFYLPFEHGG QGIQLLQEFNWLKSNAHLVTQANKKGKESPTEPEVTEWFERATRLEEISK AVNLLFQHLTFVPNRELLYDLYPYMWDMRGVISLLNSYIKWLGE------ ----------------------xxxxxxxxxxxxxxxxxxxFSKGWKETF MSGEQEPWVFRGGLTADLQ------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ------------------xxxxxxxxxxx--------------------- ----x >Tps x-----------------------xxxxxxxxxxxxxxxxxxxxxxxxxx xxxxxxxxxxxxxxxx-xxxxxxxxxxxxxxxxxxxx------------- -------------------------------------------------- ---------------------------------xxxxxxxxxxxxxxxxx xxxxxxxxxxx--------------------------------------- -------------------------------------------------- ---KLKKWGMDSYLYAPKDDYKHRAYWRELYTVEEAEHLTGLISSAVEHG ITFYYALSPGLDITYSSAKEVAALKRKLEQVSRFGCTAFALLFDDIEPEM SEADKEVFQSFAHAQVSVSNEVFQHLGQPRFMLCPTQYCAARATPNVQNS EYLNTLGAKLAPEIDIMWT------------------------------- -----------------------------------------------GAK VISRILTVESIEEITDVLRRPPVIWDNIHANDYDQKRVFLGPYSGRSPDL IPKLRGVLTNPNCEYGANFVAIHTLAQWSRCNVDGKRDPSINDTVSADIK LETETEDGGVGEDVPSTLSPNMYHPRQALRNAINEWLPEFFRPRAVWGPI AKPQQVVAAAVPIPIIPSVNTCMSLTTTTTSCSSATLPLINSNQLQALAE VCSSVTTSISEATx------------------------------------ -------------------------------------------------- -------------------------CEKALTHEDLALLCDLFYLPFEHGG QGIQLLQEFNWLKSNAHLVTQANKKGKESPTEPEVTEWFERATRLEEISK AVNLLFQHLTFVPNRELLYDLYPYMWDMRGVISLLNSYIKWLG------- -----------------------------------------FSKGWKETF MSGEQEPWVFRGGLTADLQxxxxxxSGNDLFVYKPPDVPSSxxxTI---- ------------------------------------RPxLPMDESNVYDV -------------------------LVGGFLSLSGEFCFVVEDEVGLVGY ALAALDAKQFHKKLELDWLPDMCDKYPSPNKTADQGMSRPE--------- -------------------------------------------------- -------------ELMSWFHTFKGDVPESIHSQHPSVMCCSLLPTVLDQS VAKRMITCLLAALRANGSFG-------------------xxxxxxxxxxx xxxxxxxxxxxxxxxxLSPxxxxxxxTx---------------------- -------------------------------------------------- ----- >Tsi x------------------------------------------------- --------------xxxxxxxxxxxxxxxxxxxxxxxx------------ -------------------------------------------------- ------------------------------x------------------- -------------------------------------------------- -------------------------------------xxxxxxxxxxxxx xxxKLKKWGMDSYLYAPKDDYKHRAYWRELYTVEEAEHLTGLISSAVEHG ITFYYALSPGLDITYSSAKEVAALKRKLEQVSRFGCTAFALLFDDIEPEM SEADKEVFQSFAHAQVSVSNEVFQHLGQPRFMLCPTQYCAARATPNVQNS EYLNTLGAKLAPEIDIMWTVVDVLQCSLPSHVLLFVLRFLQYYHHFIKKL LSIQSLVCQNNALIETMPVAETKHTFIIFIVIVIFIMFYVLPILLFPGPK VISRILTVESIEEITDVLRRPPVIWDNIHANDYDQKRVFLGPYSGRSPDL IPKLRGVLTNPNCEYGANFVAIHTLAQWSRCNVDGKRDPSINDTVSADIK LETETEDGGVGEDVPSTLSPNMYHPRQALRNAINEWLPEFFRPRVVWGPI AKPQQVVAAAVPIPIIPSVNTCMSLTTTTTSCSSATLPLINSNQLQALAE VCSSVx------------xxxxxxxxPVSGAxMNSLISETKVV------- ----CNDVVPPTGEPMDCNSTPNGSPAHATKSSEDTPMSDSVTVSPVPSS VNMQVDSSCSNTMIVESTNYSTIxxCEKALTHEDLALLCDLFYLPFEHGG QGIQLLQEFNWLKSNAHLVTQANKKGKESPTEPEVTEWFERATRLEEISK AVNLLFQHLTFVPNRELLYDLYPYMWDMRGVISLLNSYIKWLANGQFPQM VASFTLGSYTW------------------------------FSKGWKETF MSGEQEPWVFRGGLTADLQ------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- --------------------------------xxxxxxxxxxxxxxxxxx xxxxxxxxxxxxxxxx---------------------------------- ----- >Tcm x------------------------------------------------- --------------xxxxxxxxxxxxxxxxxxxxxxxx------------ -------------------------------------------------- ------------------------------x------------------- -------------------------------------------------- -------------------------------------xxxxxxxxxxxxx xxxKLKKWGMDSYLYAPKDDYKHRAYWRELYTVEEAEHLTGLISSAVEHG ITFYYALSPGLDITYSSAKEVAALKRKLEQVSRFGCTAFALLFDDIEPEM SEADKEVFQSFAHAQVSVSNEVFQHLGQPRFMLCPTQYCAARATPNVQNS EYLNTLGAKLAPEIDIMWT------------------------------- -----------------------------------------------GPK VISRILTVESIEEITDVLRRPPVIWDNIHANDYDQKRVFLGPYSGRSPDL IPKLRGVLTNPNCEYGANFVAIHTLAQWSRCNVDGKRDPSINDTVSADIK LETETEDGGVGEDVPSTLSPNMYHPRQALRNAINEWLPEFFRPRVVWGPI AKPQQVVAAAVPIPIIPSVNTCMSLTTTTTSCSSATLPLINSNQLQALAE VCSSVx------------xxxxxxxxPVSGAxMNSLISETKVV------- ----CNDVVPPTGEPMDCNSTPNGSPAHATKSSEDTPMSDSATVSPVPSS VNMQVDSSCSNTMIVESTNYSTIxxCEKALTHEDLALLCDLFYLPFEHGG QGIQLLQEFNWLKSNAHLVTQANKKGKESPTEPEVTEWFERATRLEEISK AVNLLFQHLTFVPNRELLYDLYPYMWDMRGVISLLNSYIKWLANGQFPQM VASFTLGSYTCMRxxxxxxxxxx------------------FSKGWKETF MSGEQEPWVFRGGLTADLQ------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- --------------------------------xxxxxxxxxxxxxxxxxx xxxxxxxxxxxxxxxx---------------------------------- ----- >Tce -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ---------------------MYHPRQALRNAINEWLPEFFRPRVVWGPI AKPQQVVAAAVPIPIIPSVNTCMSLTTTTTSCSSATLPLINSNQLQALAE VCSSVTTSISEATLLSVTxxxxxxxxPVSGAxMNSLISETKVV------- ----CNDVVPPTGEPMDCNSTPNGSPAHATKSSEDMPMSDSATVSPVSLS VNMQVDSSCSNTMIVESTNYSTIxxCEKALTHEDLALLCDLFYLPFEHGG QGIQLLQEFNWLKSNAHLVTQANKKGKESPTEPEVTEWFERATRLEEISK AVNLLFQHLTFVPNRELLYDLYPYMWDMRGVISLLNSYIKWLANGQFPQM VASFTLGSYTW------------------------------FSKGWKETF MSGEQEPWVFRGGLTADLQ--------------------------xxxxx xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxRPxLPMDESNVYDV CRHTCMDGMDGTECFSDQPNLVGDKLVGGFLSLSGEFCFVVEDEVGLVGY ALAALDAKQFHKKLELDWLPDMCDKYPSPNKTADQGMSRPE--------- -------------------------------------------------- -------------ELMSWFHTFKGDVPESIHSQHPSVMCCSLLSTVLDQS VAKRMITCLLAALRANGSFG-------------------xxxxxxxxxxx xxxxxxxxxxxxxxxxLSPxxxxxxxTx---------------------- -------------------------------------------------- -----