>Tge x----------------xxxxxxxDVKCEDCSYTPPHHPTxxxxxxxxxx xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx-------- -------------------------------------------------- ---------------------------------------xxxxxxxxxxx xxxxxxxxxxxxxxxxxxxxxxxxxxxxxx-------------------- -------------------------------------------------- -------------------------------------------------- ------------xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx------ -------------------------------------------------- ---x---------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -MIPKMNSSAAPCEDMWNYACGNWLKRHLVPVTQSKWGTTQELQAKY--- REQLRSLIVTLPHPVKLSSVTWKLKHFYESCMALDNLETDKDQPLHRIIN EL---------------GGWNVLREFSHFSWDYRVNLVKLHSQYGVSPFF KISVVPDPDNPERGVIKVSPAGLGLPDRSYYYRRPDSQVEASYKRYLKDA VQKLGATSTEAATFSEEIYHFEKRIAEVTPEWSALQNPLTSYTKISIGEF ENKAS--------------------------------------------- ----------------SIPLHDIIMAKYPTAKIDDTTEVLIPSDNYLTHI SSIITTSDRGNLNNYMMWNFAMAYLPYLSQDYRDIVNLYRKELTGIQEPP QRWEICVDTTQKYLGFSLAALHERGVPFDTRQEDQAVVNSMFENIKDAAK NSIQKSGWLDSKLQQYTLEKRLVCESGQLGTTIWARPTGRQTNWAPDQLG ARPTGRQANWAPGQLGAKTPSCLGAQLSLRPVRARPVGRARLAAPRWRRP VVLDRLLNSLALQVGYPPSIQAELYLDSYYKEMYVQKNNFFQNILYGVAF LQATEMSKLLAPAEEHRWIAVMAGVDAVSYIPEANKVVVPYRLLMSPFFH RHYPLSILYGTLGMQVASAVVSSILPWNVLLNPSGRLLSQDNPIVNQSLR AARWPRRFIAERIVKNQATEHVANQTALQTVIDISALKQAY--------- -----------------------NxxxAPVVLSQTxxxxxxxxxxx---- ---------------------------ALVQAVNRLPHTHQPALEQLEND ALFFLSYAQ--xxxxxxxxxxxxxxxxxxxxxxxxxxxx----------- -------------------------------------------------- ----------- >Tms x------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ---------------x---------------------------------- -------------------------------------------------- ---xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx xxxxxxxxxxxxxx------------------------------------ -MIPKMNSSAAPCEDMWNYACGNWLKRHPLPVTHSKWGSTQELQAKY--- REQLRSLIVTLPHPVKVSSVTWKLKHFYESCMALDNLETDKDQPLHRIIN EL---------------GGWNVLREFSHLSWDYRVNLVKLHSQYGVSPFF KISVVPDPDSPERAVIKVSPAGLGLPDRSYYYRRPDSQVEASYKRYLKDA VQKLGATSTEAATFSEEMYHFEKRIAEVTPEWSALQNPFTSYTKISIGEF ENKAS--------------------------------------------- ----------------SIPLHDIIMAKYPTAKIDDTTEVLIPSDNYLTHI SSIITTSDRGNLNNYMMWNFAMAYLPYLSQDYRDIVNLYRKELTGIQEPP QRWEMCVDTTQKYLGFSLAALHERGVPFDTRQEDQTVVNSMFENIKDAAK YSIRKSGWLDSKLQQYTLEK------------------------------ -------------------------------------------------- ------LNSLALQVGYPPSIQAELYLDSYYKEMYVQKNNFFQNILYGVTF LQATEMSKLLAPAEEHRWMAVMAGVDAVSYIPEANKVVVPYRLLMSPYFH RHYPLSILYGTLGMQVASAVVSSILPWNVLLNPSGRLLSQDNPIVNQSLR AARWPRRFIAEKIVKNHATEHVANQTALQTVIDISALKQAY--------- -----------------------N-------------------------- ---------------------------ALVQAVNRLPHTHQPALEQLEND ALFFLSYAQ----------------------------------------- --SLCSVSTIQQQDIDTSLSSKLEGSKLLRISLQQVPGFSDAYGCPADSS YLQSQLCEEIW >Tbi x------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ---------------xx--------------------------xxxxxxx xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx xxxx---------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx xMIPKMNSSAAPCEDMWNYACGNWLKRHLVPVTQSKWGTTQELQAKCEFD REQLRSLIVTLPHPVKLSSVTWKLKHFYESCMALDNLETDKDQPLHRIIN EL---------------GGWNVLREFSHFSWDYRVNLVKLHSQYGVSPFF KISVVPDPDNPERGVIKVSPAGLGLPDRSYYYRRPDSQVEASYKRYLKDA VQKLGATSTEAATFSEEIYHFEKRIAEVTPEWSALQNPLTSYTKISIGEF ENKAS--------------------------------------------- ----------------SIPLHDIIMAKYPTAKIDDTTEVLIPSDNYLTHI SSIITTSDRGNLNNYMMWNFAMAYLPYLSQDYRDIVNLYRKELTGIQEPP QRWEMCVDTTQKYLGFSLAALHERGVPFDTRQEDQAVVNSMFENIKDAAK NSIQKSGWLDSKLQQYTLEK------------------------------ -------------------------------------------------- ------LNSLALQVGYPPSIQAELYLDSYYKEMYVQKNNFFQNILYGVAF LQATEMSKLLAPAEEHRWMAVMAGVDAVSYIPEANKVVVPYRLLMSPYFH RHYPLSILYGTLGMQVASAVVSSILPWNVLLNPSGRLLSQDNPIVNQSLR AAQWPRRFIAERIVKNQATEHVANQTALQTVIDISALKQAY--------- -----------------------N-------------------------- -------------------------------AVNRLPHTHQPALEQLEND ALFFLSYTQ----------------------------------------- --SLCSVSTVQQQDIDTSLSSKLEGSKLLRISLQQVPAFSDAYGCSADSS YLHSQLCEEIW >Tpa -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ------------------GWNVLREFSHFSWDYRVNLVKLHSQYGVSPFF KISVVPDPDNPERGVIKV----WVLPDRSYYYRRPDSQVEASYKRYLKDA VQKLGATSTEAATFSEEIYHFEKRIAEVTPEWSALQNPLTSYTKISIGEF ENKAS--------------------------------------------- ----------------SIPLHDIIMAKYPTAKIDDTTEVLIPSDNYLTHI SSIITTSDRGNLNNYMMWNFAMAYLPYLSQDYRDIVNLYRKELTGIQEPP QRWEICVDTTQKYLGFSLAALHERGVPFDTRQEDQAVVNSMFENIKDAAK NSIQKSGWLDSKLQQYTLEK------------------------------ -------------------------------------------------- ------LNSLALQVGYPPSIQAELYLDSYYKEMYVQKNNFFQNILYGVAF LQATEMSKLLAPAEEHRWMAVMAGVDAVSYIPEANKVVVPYRLLMSPFFH RHYPLSILYGTLGMQVASAVVSSILPWNVLLNPSGRLLSQDNPIVNQSLR AARWPRRFITERIVKNQATEHVANQTALQTVIDISALKQAY--------- -----------------------N-------------------------- ---------------------------ALVQAVNRLPHTHQPALEQLEND ALFFLSYAQ----------------------------------------- --SLCSVSTVQQQDIDTSLSSKLEGSKLLRISLQQVPAFSDAYGCSADSS YLHSQLCEEIW >Tte xx------------------------------------------------ -------------------------------------------------- -------------------------------------------------- ---------------------------x-----------xxxxxxxxxxx xxxxxxxxxxxxxxxxxxxxxxxxxxxx---------------------- -------------------------------------------------- -------------------------------------------------- ----------xxxxxx---------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -MIPKMNSSAAPCEDMWNYACGNWLKRHLVPVTQSKWGTTQELQAKCEFD REQLRSLIVTLPHPVKLSSVTWKLKHFYESCMALDNLETDKDQPLHRIIN EL---------------GGWNVLREFSHFSWDYRVNLVKLHSQYGVSPFF KISVVPDPDNPERGVIKVSPAGLGLPDRSYYYRRPDSQVEASYKRYLKDA VQKLGATSTEAATFSEEIYHFEKRIAEVTPEWSALQNPLTSYTKISIGEF ENKAS--------------------------------------------- ----------------SIPLHDIIMAKYPTAKIDDTTEVLIPSDNYLTHI SSIITTSDRGNLNNYMMWNFAMAYLPYLSQDYRDIVNLYRKELTGIQEPP QRWEMCVDTTQKYLGFSLAALHERGVPFDTRQEDQAVVNSMFENIKDAAK NSIQKSGWLDSKLQQYTLEK------------------------------ -------------------------------------------------- ------LNSLALQVGYPPSIQAELYLDSYYKEMYVQKNNFFQNILYGVAF LQATEMSKLLAPAEEHRWMAVMAGVDAVSYIPEANKVVVPYRLLMSPYFH RHYPLSILYGTLGMQVASAVVSSILPWNVLLNPSGRLLSQDNPIVNQSLR AAQWPRRFIAERIVKNQATEHVANQTALQTVIDISALKQAYxxxxVQLMA RRPxAAxxxxxxxxxxxxxxxxxx-------------------------- -------------------------------AVNRLPHTHQPALEQLEND ALFFLSYAQ----------------------------------------- --SLCSVSTVQQQDIDTSLSSKLEGSKLLRISLQQVPAFSDAYGCSADSS YLHSQLCEEIW >Tce xx------------------------------------------------ -------------------------------------------------- -------------------------------------------------- ---------------------------xxxxxxxxxxxxx---------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -MIPKMNSSAAPCEDMWNYACGNWLKRHPLPVTHSKWGSTQELQAKCEFD REQLRSLIVTLPHPVKVSSVTWKLKHFYESCMALDNLETDKDQPLHRIIN EL---------------GGWNVLREFSHLSWDYRVNLVKLHSQYGVSPFF KISVVPDPDSPERAVIKVSPAGLGLPDRSYYYRRPDSQVEASYKRYLKDA VQKLGATSTEAATFSEEMYHFEKRIAEVTPEWSALQNPFTSYTKISIGEF ENKAS--------------------------------------------- ----------------SIPLHDIIMAKYPTAKIDDTTEVLIPSDNYLTHI SSIITTSDRGNLNNYMMWNFAMAYLPYLSQDYRDIVNLYRKELTGIQEPP QRWEMCVDTTQKYLGFSLAALHERGVPFDTRQEDQTVVNSMFENIKDAAK YSIRKSGWLDSKLQQYTLEK------------------------------ -------------------------------------------------- ------LNSLALQVGYPPSIQAELYLDSYYKEMYVQKNNFFQNILYGVTF LQATEMSKLLAPAEEHRWMAVMAGVDAVSYIPEANKVVVPYRLLMSPYFH RHYPLSILYGTLGMQVASAVVSSILPWNVLLNPSGRLLSQENPIVNQSLR AARWPRRFIAEKIVKNHATEHVANQTALQTVIDISALKQAY--------- -----------------------N-------------------------- ---------------------------ALVQAVNRLPHTHQPALEQLEND ALFFLSYAQxxx--------------------------xxxxxxxxxWVD KLSLCSVSTIQQQDIDTSLSSKLEGSKLLRISLQQVPGFSDAYGCPADSS YLQSQLCEEIW >Tps -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ---------------------------------------------xxxxx xxxxxxWxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx xxCFAxxxxRPQTx---------------------------xxxxxxxxx xxxxxxxxxxx--------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -MIPKMNSSAAPCEDMWNYACGNWLKRHPLPVTHSKWGSTQELQAKY--- REQLRSLIVTLPHPVKVSSVTWKLKHFYESCMALDNLETDKDQPLHRIIN EL---------------GGWNVLREFSHFSWDYRVNLVKLHSQYGVSPFF KISVVPDPDSPERGVIKVSPAGLGLPDRSYYYRRPDSQVEASYKRYLKDA VQKLGATSTEAATFSEEMYHFEKRIAEVTPEWSALQNPLTSYTKISIGEF ENKAS--------------------------------------------- ----------------SIPLHDIIMAKYPTAKIDDTTDVLIPSDNYLTHI SSIITTSDRGNLNNYMMWNFAMAYLPYLSQDYRDIVNLYRKELTGIQESP QRWEMCVDTTQKYFGFSLAALHERGVPFDTRQEDQTVVNSMFENIKDAAK YSIHKSGWLDSKLQQYTLEK------------------------------ -------------------------------------------------- ------LNSLALQVGYPPSIQAELYLDSYYKEMYVQKNNFFQNILYGVTF LQATEMSKLLAPAEEHRWMAVMAGVDAVSYIPEANKVVVPYRLLMSPYFH RYYPLSILYGTLGMQVASAVVSSILPWNVLLNPSGRLLSQDNPVVNQSLR AARWPRRFIAERIVKNHATEHVANQTALQTVIDISALKQAY--------- -----------------------N-------------------------- ---------------------------ALVQAVNRLPHTHQPALEQLEND ALFFLSYAQ----------------------------------------- --SLCSVSTIQQQDIDTSLSSKLEGSKLLRISLQQVPGFSDAYGCPADSS YLQSQLCEEIW >Tdi xx------------------------------------------------ -------------------------------------------------- -------------------------------------------------- ---------------------------x-----------xxxxxxxxxxx xxxxxxxxxxxxxxxSKVxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx xxxxxxxxxxxxxxxxxxxxxx-xxxxxxxxxxxxxxxxxxxxxxxxxxx xxCFxxxxxxxQTxIFVLxxxxxxxxxxxxxxxxxxxxxxx--------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -MIPKMNSSAAPCEDMWNYACGNWLKRHPLPVTHSKWGSTQELQAKY--- REQLRSLIVTLPHPVKVSSVTWKLKHFYESCMALDNLETDKDQPLHRIIN EL---------------GGWNVLREFSHFSWDYRVNLVKLHSQYGVSPFF KISVVPDPDSPERGVIKVSPAGLGLPDRSYYYRRPDSQVEASYKRYLKDA VQKLGATSTEAATFSEEMYHFEKRIAEVTPEWSALQNPLTSYTKISIGEF ENKAS--------------------------------------------- ----------------SIPLHDIIMAKYPTAKIDDTTDVLIPSDNYLTHI SSIITTSDRGNLNNYMMWNFAMAYLPYLSQDYRDIVNLYRKELTGIQESP QRWEMCVDTTQKYFGFSLAALHERGVPFDTRQEDQTVVNSMFENIKDAAK YSIHKSGWLDSKLQQYTLEK------------------------------ -------------------------------------------------- ------LNSLALQVGYPPSIQAELYLDSYYKEMYVQKNNFFQNILYGVTF LQATEMSKLLAPAEEHRWMAVMAGVDAVSYIPEANKVVVPYRLLMSPYFH RYYPLSILYGTLGMQVASAVVSSILPWNVLLNPSGRLLSQDNPVVNQSLR AARWPRRFIAERIVKNHATEHVANQTALQTVIDISALKQAY--------- -----------------------N-------------------------- ---------------------------ALVQAVNRLPHTHQPALEQLEND ALFFLSYAQ----------------------------------------- --SLCSVSTIQQQDIDTSLSSKLEGSKLLRISLQQVPGFSDAYGCPADSS YLQSQLCEEIW >Tcm xx------------------------------------------------ -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -MIPKMNSSAAPCEDMWNYACGNWLKRHPLPVTHSKWGSSQELQAKCEFD REQLRSLIVTLPHPVKVSSVTWKLKHFYESCMALDNLETDKDQPLHRIIN ELDEHMEMAELYAHIFSGGWNVLREFSHFSWDYRVNLVKLHSQYGVSPFF KISVVPDPDSPERGVIKVSPAGLGLPDRSYYYRRPDSQVEASYKRYLKDA VQKLGATSTEAATFSEEMYHFEKRIAEVTPEWSALQNPLTSYTKISIGEF ENKAS--------------------------------------------- ----------------SIPLHDIIMAKYPTAKIDDTTDVLIPSDNYLTHI SSIITTSDRGNLNNYMMWNFAMAYLPYLSQDYRDIVNLYRKELTGIQEPP QRWEMCVDTTQKYFGFSLAALHERG------------VNSMFENIKDAAK YSIHKSGWLDSKLQQYTLEK------------------------------ -------------------------------------------------- ------LNSLALQVGYPPSIQAELYLDSYYKEMYVQKNNFFQNILYGVTF LQATEMSKLLAPAEEHRWMAVMAGVDAVSYIPEANKVVVPYRLLMSPYFH RHYPLSILYSTLGMQVASAVVSSILPWNVLLNPSGRLLSQDNPIVNQSLR AARWPRRFIAERIVKNHATEHVANQTALQTVIDISALKQAY--------- -----------------------N-------------------------- ---------------------------ALVQAVNRLPHTHQPALEQLEND ALFFLSYAQ----------------------------------------- --SLCSISTIQQQDIDTSLSSKLEGSKLLRISLQQVPGFSDAYGCPADSS YLQSQLCEEIW >Tsi MTRxxxNDYLSTPILxxxxxxxxxDVKCE--------------------- -----------------------------------------GVMLQLRVH LDxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxFL Fxxxxxxxxxxxxxxxxxxxxxxxxxxx-----------xxxxxxxxxxx xxxxxxxxxxxxxxxSKVxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx xxxxxxWxxxxxxxxxxxxxxxxxxx--------xxxxxxxxxxx----- -----------------xxxxxxxxxxxxxxxxxxxxxxx---------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- xMIPKMNSSAAPCEDMWNYACGNWLKRHPLPVTHSKWGSTQELQAKCEFD REQLRSLIVTLPHPVKVSSVTWKLKHFYESCMALDNLETDKDQPLHRIIN EL---------------GGWNVLREFSHFSWDYRVNLVKLHSQYGVSPFF KISVVPDPDSPERGVIKVSPAGLGLPDRSYYYRRPDSQVEASYKRYLKDA VQKLGATSTEAATFSEEMYHFEKRIAEVTPEWSALQNPLASYTKISIGEF ENKASxVTWRSRGKVSDFCAGGQGSIPGPGTDLSDYQPLPSPLTRHLVNV GNARPLHLTITLPLHISIPLHDIIMAKYPTAKIDDTTDVLIPSDNYLTHI SSIITTSDRGNLNNYMMWNFAMAYLPYLSQDYRDIVNLYRKELTGIQEPP QRWEMCVDTTQKYFGFSLAALHERGVPFDTRQEDQTVVNSMFENIKDAAK YSIHKSGWLDSKLQQYTLEK------------------------------ -------------------------------------------------- ------LNSLALQVGYPPSIQAELYLDSYYKEMYVQKNNFFQNILYGVTF LQATEMSKLLAPAEEHRWMAVMAGVDTVSYIPEANKVVVPYRLLMSPYFH RHYPLSILYGTLGMQVASAVVSSILPWNVLLNPSGRLLSQDNPIVNQSLR AARWPRRFIAERIVKNHATEHVANQTALQTVIDISALKQAY--------- -----------------------Nx-------------------xxSVYY TERFxLFxDILxxxxxxxxxxxxxxxxALVQAVNRLPHTHQPALEQLEND ALFFLSYAQ----------------------------------------- --SLCSVSTIQQQDIDTSLSSKLEGSKLLRISLQQVPGFSDAYGCPADSS YLQSQLCEEIW