>Tge M------------------------------------------------- -------------------------------------------------- ----------------------------------------------xxxx xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx xxxxxxxxxxxxxxxxxxxxPELNESFLKSNENVDHEISKDSQVHLPYAT HQPAMVYPNMESTTKHSDCDIDMAEKPSMMSNLRVKYERGPLSWMADYEH FDDAQLFDVSESVQSNYGTPDKSIPVSSVPCGGCGALLHCQVRHTHGEDE INQNQEESQAEEDTIKSHTVDSDVILLNDESSYPITVTESSGEPNDDSAS NTTPHTAIANIGPPKPEYSCFKTSKSSFDPGIPGYLPSELYACYSKSELR SITC---------------------------------------------- ------------TSRPVVVVGNKVDLLPADCPGYLDHVKNCVKYSLESSG IDAANIKHIALVSASTGYGVEELITKLQNLWDYK---------------- ----xxxxxxxxxxxxxHSxxxxxxxxxxxxxxxxxxxxx---------- -----------------------xxxxxTCPGFHWCSxxSSP-------- ----------------------GYSYPGLHHLAVRSGLxDVYLIGCTNVG KSTLFNALLQSDYCKVKAVDLIQRATTSPWPGTTLNLLK----------- ---FPILRPEGWRLYQRTKRLLSNRSRVVEERKLRRLQTNDTNKPDNPTL IGHIGRTFLPKPPEEKADPFSVSQRASGGPMCMPGLDPHDKDFSLSRWCY DTPGTVQPDQ-----------------------------------ILDLL TTEELLLTLPRTTLVPRTFSIKEGCTLFIAGLARLDYLEGSL---FTVFA AGSLPITVCRITDADYLYSELLGSELLAVPSGGSARLQGWPGLSSV---- -------------------------------------------------- xxxxxx-----------xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx------ -------------------------------------------------- -------x >Tsi -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -----------------------------PCGGCGALLHCQ--------- -------------------------------------------------- ----------------------------DPGIPGYLPSELYTCYSKSELR SITCQRCHFMKHYNMALNVNVSPDEYPRLISMIQHHRALVILLVDLMDFP CSIWPQILNIIGTSRPVVVVGNKVDLLPADCPGYLDHVKNCVKYSLESTG IDAANIKHIALVSASTGYGVEELITKLQSLWDYK---------------- -------------------------------------------------- -------------------------------------------------- ----------------------G----------------DVYLIGCTNVG KSTLFNALLQSDYCKVKAVDLIQRATTSPWPGTTLNLLK----------- ---FPILRPEGWRLYQRAKRLVSNRSRVVAERKLRKLQTNDTNKPDNPTL IGHIDRTFLPKPPEEKADPFSVSQRAFGGPMFMPGLDPHDKDFSLSRWCY DTPGTVQPDQ-----------------------------------ILDLL TTEELLLTLPRTTLVPRTFSIKKGCTLFIAGLARLDYLEGSLSSKFTVFA AESLPITVCRITDADYLYSELLGSELLAVPSGDSARLQGWPGLSSVPHPL QVKGLSWTESCADIVLSSA------------------------------- G------------------------------------------------- -------------------------------------------------x xxxxxGPNxxxxLRAWTPDARGVYLRQPALLRYAVNMRGPRIRxxxxxxx xxxxxIKx >Tbi MLVRMVFNELGKCTVLYFRSHxxxxxxDFxxxxxLSSYSxxxxxxxxxxx xxxxxxxxxxxxxxHTxxTRKDKLNHMRSKSxxxxYYSxFLHLKPKILYN SVFEVAKMKFGFVKRKILDEINKRAKINALNNNLENNGCVALKYLEVP-- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- --------------------PELNESFLKSNENVDHDISKDSQVHLPYAT HQPTMMYPNMESTTNHSDRDIDIAEKPSMMSNLGVKYERGPLSWMADYEH FDDAQLFDVSESVQSNYGTPDKSIPVSSVPCGGCGALLHCQ--------- -------------------------------------------------- ----------------------------DPGIPGYLPSELYACYSKSELR SITCQRCHFMKHYNMALNVNVSPDEYERLISMIQHHRALVILLVDLMDFP CSIWPQILNIIGTSRPVVVVGNKVDLLPADCPGYLDHVKNCVKYSLESSG IDAANIKHIALVSASTGYGVEELITKLQNLWDYK---------------- -------------------------------------------------- -------------------------------------------------- ----------------------G----------------DVYLIGCTNVG KSTLFNALLQSDYCKVKAVDLIQRATTSPWPGTTLNLLK----------- ---FPILRPEGWRLYQRTKRLLSNRSRVVVERKLRRLQTNDTNKPDNPTL IGHIDRTFLPKPPEEKADPFSVSQRASGGPMCMPGLDPHDKDFSLSRWCY DTPGTVQPDQ-----------------------------------ILDLL TTEELLLTLPRTTLVPRTFSIKEGCTLFIAGLARLDYLEGSLSSKFTVFA AGSLPITVCRITDADYLYSELLGSELLAVPSGGSARLQGWPGLSSVPHTL QVNGLSxxxxxADxxxxxx------------------------------- x------------------------------------------------- -------------------------------------------------x xxxxxxxxxxxxxxxxxxNxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx xxxxxxxx >Tps MLVKMVFNDLSKCTVLYFRSHIFPKTCDLQFDKFCCSYSKFFKKEHILYH PQNSNLHFQKFNFIHTVCTRKDKLSHKQSKSD-LEYDSKFLHLKPKILFN SVFEVAKMKYGFVKRKILADINKRSKINALNSNLDNNGCVALKYLKVL-- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- --------------------PELNESFLKSSEIVNHEISKDNQVHLPYAT DQPTMVWPNMESTTNHSDR--DIMEKLSIMSNLGVKDERGPMSWMADYEH FDDAQLFDVSESVQSNYGTPNRSIPVSSVPCGGCGALLHCQ--------- -------------------------------------------------- ----------------------------DPGIPGYLPSELYTCYSKSELR SITCQRCHFMKHYNMALNVNVSPDEYPRLISMIQHHRALVILLVDLMDFP CSIWPQILNIIGTSRPVVVVGNKVDLLPADCPGYLDHVKNCVKYSLESTG IDAANIKHIALVSASTGYGVEELITKLQSLWDYK---------------- -------------------------------------------------- --x--------------------------------------xxxxxxxxx xxxxxxxxxxxxxxxxxxxxLGG----------------DVYLIGCTNVG KSTLFNALLQSDYCKVKAVDLIQRATTSPWPGTTLNLLK----------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -----xxxxxxxxxxxxx-------------------------------- ------------------------------------------xxxxxxxx x------------------------------------------------- -------x >Tdi MLVKMVFNDLSKCTVLYFRSHIFPKTCDLQFDKFCCSYSKFFKKEHILYH PQNSNLHFQKFNFIHTVCTRKDKLSHKQSKSD-LEYDSKFLHLKPKILFN SVFEVAKMKYGFVKRKILADINKRSKINALNSNLDNNGCVALKYLKVL-- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- --------------------PELNESFLKSSEIVNHEISKDNQVHLPYAT DQPTMVWPNMESTTNHSDR--DIMEKLSIMSNLGVKDERGPMSWMADYEH FDDAQLFDVSESVQSNYGTPNRSIPVSSVPCGGCGALLHCQ--------- -------------------------------------------------- ----------------------------DPGIPGYLPSELYTCYSKSELR SITCQRCHFMKHYNMALNVNVSPDEYPRLISMIQHHRALVILLVDLMDFP CSIWPQILNIIGTSRPVVVVGNKVDLLPADCPGYLDHVKNCVKYSLESTG IDAANIKHIALVSASTGYGVEELITKLQSLWDYKxxxxxxxx-------- xxxxx----------------------------------xxxxxxxxxxx xxx--------------------------------------xxxxxxxxx xxxxxxxxxxxxxxxxxxxxLGG----------------DVYLIGCTNVG KSTLFNALLQSDYCKVKAVDLIQRATTSPWPGTTLNLLK----------- ---FPILRPEGWRLYQRAKRLVSNRSRVVAERKLRKLQTNDTNKPDNPTL IGHIDRTFLPKPPEEKADPFSVSQRAFGGPMFMPGLDPHDKDFSLSRWCY DTPGTVQPDQ-----------------------------------ILDLL TTEELLLTLPRTTLVPRTFSIKKGCTLFIAGLARLDYLEGSLSSKFTVFA AESLPITVCRITDADYLYSELLGSELLAVPSGGSARLQGWPGLSSVPHPL QVKGLSWTESCADIVLSSA------------------------------- Gxxxxx-------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------- >Tcm MLVKMVFNDLSKCTVLYFRSHIFPRTCDLQFDKFCCSYSKFFKKEHILYH PQNSNLHFQKFHFIHTACTRKDKLSHKQSKSD-LEYDSKFLHLKPKILFN SVFEVAKMKYGFVKRKILADINKRSKINALNSNLDNNGCVALKYLKVL-- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- --------------------PELNESFLKSSEIVNHEISKDNQVHLPYAT HQPTMVWPNMESTTNHSDR--DIAEKLSIMSNLGVKDERGPMSWMADYEH FDDAQLFDVSESVQSNYGTPNRSIPVSSVPCGGCGALLHCQ--------- -------------------------------------------------- ----------------------------DPGIPGYLPSELYTCYSKSELR SITCQRCHFMKHYNMALNVNVSPDEYPRLISMIQHHRALVILLVDLMDFP CSIWPQILNIIGTSRPVVVVGNKVDLLPADCPGYLDHVKNCVKYSLESTG IDAANIKHIALVSASTGYGVEELITKLQSLWDYK---------------- -------------------------------------------------- --xxxxxxxxxxxxxxxxxxxxxxxxxxxxxGFRWxxTQSxx-------- ----------------------G----------------DVYLIGCTNVG KSTLFNALLQSDYCKVKAVDLIQRATTSPWPGTTLNLLKGxVQKGKGVRG KDxFPILRPEGWRLYQRAKRLVSNRSRVVAERKLRKLQTNDTNKPDNPTL IGHIDRTFLPKPPEEKADPFSVSQRAFGGPMFMPGLDPHDKDFSLSRWCY DTPGTVQPDQSQQRLYNLVSLSLSERLLRLRTGWLAITVECIQTVILDLL TTEELLLTLPRTTLVPRTFSIKKGCTLFIAGLARLDYLEGSLSSKFTVFA AESLPITVCRITDADYLYSELLGSELLAVPSGDSARLQGWPGLSSVPHPL QVKGLSWTESCADIVLSSAxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx x------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------- >Tte x------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ----------------------------------------T--------- -------------------------------------------------- ----------------------------DPGIPGYLPSELYACYSKSELR SITCQRCHFMKHYNMALNVNVSPDEYERLISMIQHHRALVILLVDLMDFP CSIWPQILNIIGTSRPVVVVGNKVDLLPADCPGYLDHVKNCVKYSLESSG IDAANIKHIALVSASTGYGVEELITKLQNLWDYKxxxxxxxxxxxxxxxx x------------------------------------------------- --xxxxxxxxxxxxxxxxxxxx-------------------x-xxRxxxx xxxxxxxxxxxxxxxxxxxxLGG----------------DVYLIGCTNVG KSTLFNALLQSDYCKVKAVDLIQRATTSPWPGTTLNLLK----------- ---FPILRPEGWRLYQRTKRLLSNRSRVVVERKLRRLQTNDTNKPDNPTL IGHIDRTFLPKPPEEKADPFSVSQRASGGPMCMPGLDPHDKDFSLSRWCY DTPGTVQPDQ-----------------------------------ILDLL TTEELLLTLPRTTLVPRTFSIKEGCTLFIAGLARLDYLEGSLSSKFTVFA AGSLPITVCRITDADYLYSELLGSELLAVPSGGSARLQGWPGLSSVPHTL QVNGLSWTESCADIVLSSA------------------------------- Gxxxxx-----xxxx----------------------------------- -------------------------------------------------- -------------------------------------------------- -------- >Tpa -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ----------------------------DPGIPGYLPSELYACYSKSELR SITCQRCHFMKHYNMALNVNVSPDEYERLISMIQHHRALT---------- ----------LSTSRPVVVVGNKVDLLPADCPGYLDHVKNCVKYSLESSG IDAANIKHIALVSAITGYGVEELITKLQNLWDYK---------------- ----xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx---------- -----------------------xxxxxxxxxxxxxxTHPxx-------- ----------------------G----------------DVYLIGCTNVG KSTLFNALLQSDYCKVKAVDLIQRATTSPWPGTTLNLLK----------- ---V---------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------x