>Tge -----------------------MVTGVRMLDGAVNDAVEARALGLNPDY IDIYSASWGPEDDG------------------x----------------- ---------------------------TGRKGKGSIFVWASGNGGSHTDS CNCD---------------------------GYANSIYTLSISSATQGGR KPWYLEECSSTLATTYSSGTPGQDRSVATVDMDPKLRPDRLCTLDHTGTS ASAPLAAGMAALALQANPELTWRDVQYLVVLTSR---------------- ----------------xxxxxxxxxWTVxxxxxx---------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- xxxxxxxxxMDAGAMTSLAEVWTxxxxxHICxxxEVAxx----------- -------------------------------------------------- -------------------xxxIRxxIPESQxxxxxRELIPExxxxxxxx xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx xxxxxxxxxxxxxxxxxxxxxxKIEASAGSTLTVSLDVNGCEGTLNEVRH LEHVQCKVTLQFSPRGNLQIVLMSPMGTSSTLLFERPRDIISSTFKDWSF LSVHYWGEYPQGKWTLDIINSGDRIANESGILKKWQLVFFGTAANPIRIK SKEQKSEKQQTDFVEHFDSNIFNEQDFVNTQSISENDQNTLVSSMDDVNN ISIQKSEKYMDQKIQNNCDPECDFQGCYGEGPSLCVACRHHKLGK----- -------------------------------------------------- --------------GECVRRCPSGSFPGQTGVCLSCHESCGTCTGAGGGN CLTCAPAHLHVTDLAVCLQQCPEGYIH----------------------- -------------------------------------------------- ---------xxxxxxxxxxKPNCASCxDQPDHCDICENHLxxxxxxCYxx xxxxxYETEDYS-------------------------------------- ------------------------------CAPCHSSCETCSGPTSIQCI SCHHGHFSLNGGCLKVCPQGYYEHRKRKECLECPPGCSTCNSTYCITCEQ GWKLDKNGGCALCGSSHCDLGEYWEAGHCRPCHSTCETCTGPTEYxxISC ESPLLLxxTxxLTTCLTGLYLDQDTCVxxxxxxxxxTSRVNCTQCTPGLH LQGGECRAACxxxYYS---------------------------------- ------------------------------NHGVCAKCYLSCMTCSGPDK THCVSCPDEWQLAGGECSPMCPGGFFLSRFGCQRCHPYCQTCAGEGRLNC TSCAAPFMLERGLCIKCLDSQYYDPTTQLCRPCHESCLTCSGQGSFSCLS CLLPLHLDRLSHQCVQCCAEKKHWDCCHCDNVTGECLSSSPASKRRKAAS IQHAHDYHKDSGGTARLYSSFVNVTQLAVIASFTVTVMVLILAVLL---- -------------------------------------------------- ----------------------x >Tpa x---------xxxxxxxxxxxxx--------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- --------------------GEYWEAGHCRPCHSTCETCTGPTEYxxISC ESPLLLxxTxxLTTCLTGLYLDQDTCMxxxxxxxxxTSRVNCTx------ -------------YYS---------------------------------- ------------------------------NHGVCAKCYLSCMTCSGPDK THCVSCPDEWQLAGGECSPMCPGGFFLSRFGCQRCHPYCQTCAGEGRLNC TSCAAPFMLERGLCIKCLGSQYYDPTTQLCRPCHESCLTCSGQGSFSCLS CLLPLHLDRLSHQCVQCCAEKKHWDCCHCDNVTGECLSSSPASKRRKAAS IQHAHDYHKDSGGTARLYSSFVNVTQLAVIASFTVTVMVLILAVLL---- -------------------------------------------------- ----------------------x >Tsi xxxxxxxxxxx--------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ----------------------KIEASAGSTLTVSLDVNGCEGTLNEVRH LEHVQCKVTLQFSPRGNLQIVLMSPMGTSSTLLFERPRDIISSTFKDWSF LSVHYWGEYPQGKWTLDIINSGDRIANESGILKKWQLVFFGTAANPIRIK SKKQKSEKQQTDFVEHFDSNIFNEQDFVNTQSISENDQNTLVSLMDDVNN ISIQKNDKYMDQKIQNNCDPECDFQGCYGEGPSLCVACRHHTLGK----- -------------------------------------------------- --------------GECVRRCPSGSFPGQTGMCISCHESCGTCTGAGGGN CITCAPAHLHVTDLAVCLQQCPEGYIHxxx-------------------- --------------------------------xxxxxxxxxxxxxxxxxx xxxxxxxxxx---------------------------------------- -------------------------------------------------- -------------------------------------------------- ---------------VCPQGYYEHRKRKECLECPPGCSTCNSTYCITCEE GWKLDKNGGCVLCGSSHCDLGEYWEAGHCRPCHSTCETCTGPTEYxxISC ESPLLLxxTxxLTTCLTGLYLDQDTCMxxxxxxxxxTSRVNCTQCTPGLH LQGGECRAACxxxYYS---------------------------------- ------------------------------DHGVCAKCYMSCRTCSGPDK SHCVSCPNEWQLAGGECSPVCPGGFFLSRFGCQRCHPYCQTCAGEGRLNC TSCTAPFMLERGLCIKCLGSQYYDPTTQLCRPCHESCLTCSGQGSFSCLS CLLPLHLDRLSHQCVQCCAEKKHWDCCHCDNVTGECQSSSPASKRRKAAS IQHAHDYHKDSGGTARLYSSFVNVTQLAVIASFTVTVMVLILAVLLAKSW LRQRLWRMDDGYKRLSTNICEAIDEKVETLKRDNSCQESY-NEEQLFV-- ---------------------KT >Tcm xxxxxxxxxxx--------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ----------------------KIEASAGSTLTVSLDVNGCEGTLNEVRH LEHVQCKVTLQFSPRGNLQIVLMSPMGTSSTLLFERPRDIISSTFKDWSF LSVHYWGEYPQGKWTLDIINSGDRIANESGILKKWQLVFFGTAANPIRIK SKKQKSEKQQTDFVEHFDSNIFNEQDFVNTQSISENDQNTLVSLMDDVNN ISIQKNDKYMDQKIQNNCDPECDFQGCYGEGPSLCVACRHHTLGK----- -------------------------------------------------- --------------GECVRRCPSGSFPGQTGMCISCHESCGTCTGAGGGN CITCAPAHLHVTDLAVCLQQCPEGYIHxxx-------------------- --------------------------------xxxxxxxxxxxxxxxxxx xxxxxxxxxx---------------------------------------- -------------------------------------------------- -------------------------------------------------- ---------------VCPQGYYEHRKRKECLECPPGCSTCNSTYCITCEE GWKLDKNGGCVLCGSSHCDLGEYWEAGHCRPCHSTCETCTGPTExxxISC ESPLLLxxTxxxTTCLTGLYLDQDTCxxxxxxxxxxxxxxxxxxxxPGLH xxGGECRAACxxxYYS---------------------------------- ------------------------------DHGVCAKCYMSCRTCSGPDK SHCVSCPDEWQLAGGECSPVCPGGFFLSRFGCQRCHPYCQTCAGEGRLNC TSCTAPFMLERGLCIKCLGSQYYDPTTQLCRPCHESCLTCSGQGSFSCLS CLLPLHLDRLSHQCVQCCAEKKHWDCCHCDNVTGECQSSSPASKRRKAAS IQHAHDYHKDSGGTARLYSSFVNVTQLAVIASFTVTVMVLILAVLLAKSW LRQRLWRMDDGYKRLSTNICEAIDEKVETLKRDNSCQESY-NEEQLFV-- ---------------------KT >Tps -----------------------MVAGVRMLDGAVNDAVEARALGLNPDY IDIYSASWGPEDDG------------------T------FSMxxNLVxxx xxxxxVWHEGGSSSILSVxKIxxxxxxQGRKGKGSIFVWASGNGGSHTDS CNCDxxxxYSxxxxxxxxxxxxxTNVxxxxxx-----------------R KPWYLEECSSTLATTYSSGTPGQDRSVATVDMDPKLRPDNLCTLDHTGTS ASAPLAAGMAALALQANPELSWRxxQYLVVLTSR---------------- ----------------xxxxxxxxxxxVxxxxxxxxxxxxxxxCSIWWYS PPDLDLWRGRLAGQSxxSTGRYLVV-------------LTSR-------- -----------SRPLEGETGWTVNGVNRKGEYQLGVTTCSIWWYSPPGLD LWRVRLAGQSMVSxGRVxxxxxGDWLDSQWCQQEGSRPLEGETGWTVNGV NxxxxxxxxxTTCIWWSSPPGLDLWRxxxxxxxxxxxxxxxxxxxxxxxx xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxS xWWYSPxxxYLWRGRLAGQSMVSIGRYLVVLTSRxxxxxxxxxxxxxxxx xxxxFGxGLMDAGAMTSLAEVWTNVxxxxxCxxxEVAxx----------- -------------------------------------------------- -------------------R------------------------------ -------------------------------------------------- ----------------------KIEASAGSTLTVSLDVNGCEGTLNEVRH LEHVQCKVTLQFSPRGNLQIVLMSPMGTSSTLLFERPRDIISSTFKDWSF LSVHYWGEYPQGKWTLDIINSGDRIANES-------------AANPIRIK SKKQKSEKQQTDFVEHFDSNIFNEQDFVNTQSISENDQNTLVSLMDDVNN ISIQKNDKYMDQKIQNNCDPECDFQGCYGEGPSLCVACRHHKLGK----- -------------------------------------------------- --------------GECVRRCSSGSFPGQTGVCISCHESCGTCTGAGGGN CITCAPAHLHVTDLAVCLQQCPEGYIH----------------------- -------------------------------------------------- -------------------------------------------------- -----------GxxxxxxxxQxKISVSxxxxxxxxxxxxxxxxxxxxxxx xxxxxVxxASQIVPLAxxxxxxxxxxxxxxCAPCHSSCKTCGGPTSIHCI SCHHGHFSLNGGCLKVCPQGYYEHRKRKECLECPPGCSTCNSTYCITCEE GWKLDKNGGCVLCGSSHCDLGEYWEAGHCRPCHSTCETCTGPTEYxxISC ESPLLLxxTxxLTTCLTGLYLDQDTCMxxxxxCQxxTSRVNCTKCTPGLH LQGGECRAACxxxxxx---------------------------------- ------------------------------DHGVCAKCYMSCRTCSGPNK SHCVSCPDEWQLAGGECSPVCPGGFFLSRFGCQRCHPYCQTCAGEGRLNC TSCTAPFMLERGLCIKCLGSQYYDPTTQLCRPCHESCLTCSGQGSFSCLS CLLPLHLDRLSHQCVQCCAEKKHWDCCHCDNVTGECLSSSPASKRRKAAS IQHAHDYHKDSGGTARLYSSFVNVTQLAVIASFTVTVMVLILSVLLAKSW LRQRLWRMDDGYKRLSTNICEAIDEKVETLKRDNSCQESYNNEEQLFV-- ---------------------KT >Tms -----------------------MVAGVRMLDGAVNDAVEARALGLNPDY IDIYSASWGPEDDGKTVDGPGPLARRAFIHGVT----------------- ---------------------------KGRKGKGSIFVWASGNGGSHTDS CNCD---------------------------GYANSIYTLSISSATQGGR KPWYLEECSSTLATTYSSGTPGQDRSVATVDMDPKLHPDNLCTLDHTGTS ASAPLAAGMAALALQANPELTWRDVQYLVVLTSR---------------- ----------------xxxxxxxxxWTVxxxxxx---------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- xxxxFGxxLMDxGAMTSLAEVWTNVxxxxxxxxxEVAxx----------- -------------------------------------------------- -------------------R------------------------------ -------------------------------------------------- ----------------------KIEASAGSTLTVSLDVNGCEGTLNEVRH LEHVQCKVTLQFSPRGNLQIVLMSPMGTSSTLLFERPRDIISSTFKDWSF LSVHYWGEYPQGKWTLDIINSGDRIANESGILKKWQLVFFGTAANPIRIK SKEQKSEKQQTDFVEHFDSSIFNEQDFVNTQSISENDQNTLVSLMDDVNN ISIQKSEKYMNRKIQNNCDPECDFQGCYGEGPSLCVACRHHKLGKVKPTN HICTMLTPGGKPWQPSPSNRRFQRLSRVINFKYSCFAAMRRLTANQRPGR KKRLMYDDVMPVVTGECVRRCPSGSFPGQTGVCIPCHESCGTCTGAGGGN CITCAPAHLHVTDLAVCLQQCPEGYIH----------------------- -------------------------------------------------- ---------xxxxxxxxxxKPNCASCxDQPDHCDICENHLxxxxxxxxxx xxxxxYETEDYS-------------------------------------- ------------------------------CAPCHSSCETCRGPTSIHCI SCHHGHFSLNGGCLKVCPQGYYEHRKRKECLECPPGCSTCNSTYCITCEE GWKLDKNGGCALCGSSHCDLGEYWEAGHCRPCHSTCETCTGPTEYxxISC ESPLLLxxTxxLTTCLTGLYLDQDTCMxxxxxxxxxTSRVNCTQCTPGLH LQGGECRAACxxxYYS---------------------------------- ------------------------------DHGVCAKCYMSCRTCSGPDK SHCVSCPNEWQLAGGECSPVCPGGFFLSRFGCQRC---------EGRLNC TSCTAPFMLERGLCIKCLGSQYYDPTTQLCRPCHESCLTCSGQGSFSCLS CLLPLHLDRLSHQCVQCCAEKKHWDCCHCDNVTGECLSSSPASKRRKAAS IQHAHDYHKDSGGTARLHSSFVNVTQLAVIASFTVTMMVLILAVLLAKSW LRQRLWRMDDGYKRLSTNICEAIDEKAETLKRDNSCQESYNNEEQLFV-- ---------------------KT >Tdi -----------------------MVAGVRMLDGAVNDAVEARALGLNPDY IDIYSASWGPEDDGKTVDGPGPLARRAFIHGVTxCGQGTFGMKVALVxxx xWPRYVWHEGGSSSILSVx--------KGRKGKGSIFVWASGNGGSHTDS CNCD---------------------------GYANSIYTLSISSATQGGR KPWYLEECSSTLATTYSSGTPGQDRSVATVDMDPKLRPDNLCTLDHTGTS ASAPLAAGMAALALQANPxxxxxxxQYLVVLTSRxxxxxxxxxxxxxxxx xxxxCHHMYLVVLTSRSRPLEGETGWTVNGVNRKGEYQLGVTTC-IWWYS PPDLDLWRGRLAGQSMVSxG---------------------RIxxxxxGD WLDSQWCQQEGSRPLEGETGWTVNGVNxxxxxxxxxTTC-IWWYSPPDLD LWRxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx xxxxxxxxxxxxxxWWYSPxxxDLWRGRLAGQSMVSTGRVSTFGGGDWLD SQWCQQEG-------------xxxxxxxxxxxxxxxxxx----------- -------------------------------------------------- xxxxFGxGLMDAGAMTSLAEVWTNVxxxxxCxxxEVxxx----------- -------------------------------------------------- -------------------R------------------------------ -------------------------------------------------- ----------------------KIEASAGSTLTVSLDVNGCEGTLNEVRH LEHVQCKVTLQFSPRGNLQIVLMSPMGTSSTLLFERPRDIISSTFKDWSF LSVHYWGEYPQGKWTLDIINSGDRIANES-------------AANPIRIK SKKQKSEKQQTDFVEHFDSNIFNEQDFVNTQSISENDQNTLVSLMDDVNN ISIQKNDKYMDQKIQNNCDPECDFQGCYGEGPSLCVACRHHKLGK----- -------------------------------------------------- --------------GECVRRCPSGSFPGQTGVCISCHESCGTCTGAGGGN CITCAPAHLHVTDLAVCLQQCPEGYIH----------------------- -------------------------------------------------- -------------------------------------------------- -----------GxxxxxxxxQxKISVSxxxxxxxxxxxxxxxxxxxxxx- ---------------------------------------TCGGPTSIHCI SCHHGHFSLNGGCLKVCPQGYYEHRKRKECLECPPGCSTCNSTYCITCEE GWKLDKNGGCVLCGSSHCDLGEYWEAGHCRPCHSTCETCTGPTEYxxISC ESPLLLxxTxxLTTCLTGLYLDQDTCMxxxxxCQxxTSRVNCTQCTPGLH xxxxxx-------------------------------------------- -------------------------------------------------- --------------------------------------------EGRLNC TSCTAPFMLERGLCIKCLGSQYYDPTTQLCRPCHESCLTCSGQGSFSCLS CLLPLHLDRLSHQCVQCCAEKKHWDCCHCDNVTGECLSSSPASKRRKAAS IQHAHDYHKDSGGTARLYSSFVNVTQLAVIASFTVTVMVLILAVLL---- -----------------------------------------------xxx xxxxxxxxxxxxxxxxxxxxxxx >Tce -----------------------MVAGVRMLDGAVNDAVEARALGLNPDY IDIYSASWGPEDDGKTVDGPGPLARRAFIHGVT----------------- ---------------------------KGRKGKGSIFVWASGNGGSHTDS CNCD---------------------------GYANSIYTLSISSATQGGR KPWYLEECSSTLATTYSSGTPGQDRSVATVDMDPKLHPDNLCTLDHTGTS ASAPLAAGMAALALQANP-------------------------------- -------------------------------------------------- ------------------------xxxxxxxAVSGSTHLQ---------- -------------------------------------------------- -------------------------------------------------- ---------------------------------------xxxxxx----- -------------------------------------xx----------- -------------------------------------------------- xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxEVAxxxxxxxxxxxxx xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxT YLxxxxxxxxxxxxxxxxxx------------------------------ -------------------------------------------------- ----------------------KIEASAGSTLTVSLDVNGCEGTLNEVRH LEHVQCKVTLQFSPRGNLQIVLLSPMGTSSTLLFERPRDIISSTFKDWSF LSVHYWGEYPQGKWTLDIINSGDRIANESGILKKWQLVFFGTAANPIRIK SKEQKSEKQQTDFVEHFDSSIFNEQDFVNTQSISENDQNTLVSLMDDVNN ISIQKSEKYMNRKIQNNCDPECDFQGCYGEGPSLCVACRHHKLGK----- -------------------------------------------------- --------------GECVRRCPSGSFPGQTGVCIPCHESCGTCTGAGGGN CITCAPAHLHVTDLAVCLQQCPEGYIHGxxxxxxxSSGFFLHLSLYNPTG LQVCISFHALEMSSREVITAAIVILRCQKKRKR----------------- ---------xxxxxxxVPCKPNCASCQDQPDHCDICENHLxxxNxxCYxx xPVYTYETEDYS-------------------------------------- ------------------------------CAPCHSSCETCRGPTSIHCI SCHHGHFSLNGGCLKVCPQGYYEHRKRKECLECPPGCSTCNSTYCITCEE GWKLDKNGGCALCGSSHCDL------------------------------ -------------------------------------------------- --------------VSATTARYSVLDHVSHRLVPGPRHxxxxSTHVSELY VTLSTVxxxxxxxxxxxxxxxxxxxxxxxxDHGVCAKCYMSCRTCSGPDK SHCVSCPNEWQLAGGECSPVCPGGFFLSRFGCQRC---------EGRLNC TSCTAPFMLERGLCIKCLGSQYYDPTTQLCRPCHESCLTCSGQGSFSCLS CLLPLHLDRLSHQCVQCCAEKKHWDCCHCDNVTGECLSSSPASKRRKAAS IQHAHDYHKDSGGTARLHSSFVNVTQLAVIASFTVTVMVLILAVLLAKSW LRQRLWRMDDGYKRLSTNICEAIDEKAETLKRDNSCQESYNNEEQLFE-- ---------------------KT