>Tge -------------------------------------------------- --------xx---------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------xxxxxxxxxxxxxxxxxxxxxxxxx----------VI EVVSSRGVIEISHPKDSSKDSKKMFTFDAVYDWNSRQEDLYEESIRPLVS SVLDGFNGTIFAYGQTGTGKTYTMEGPKNDPSQKGIIPKSFEQIFNYISR SSNMQYLVRASYLEIYQEDIR----------------------------- -------------------------------------------------- ----------DLLNKDPSKHLELREKPEIGVYVKDLSSFVCKSMNEIEHV MVVGNMNRSIGATNMNEHSSRSHAIFVVTIEMGATEASVKKLIRVGKLNL VDLAGSERQSKTGAS----------------------------------- xxxxxxxxxxxxxxxxxxxxxxxxxxx----------------------- --------------------DSLGGNSKTVMVANIGPASYNYDESLTTLR YANRAKNIKNKPRVNEDPKDALLRQYQQEIARLKVLLAEKHKIVEMRAQA QNQKKEKESKKTQPTPDIPSDITEEELRRKIMNGEIIISPE-------MN QKLIEEIERKKQEVIRERKETEKLQAQLMFMESKLLSGGKNIVDHTNEQQ RALELRKQEIAERKKREVEMRxxxxxQEANSMEFRETFTNLKQEAEVKTR KLKKLFSKLQATKLEMNDLTEEFNRDRRELELTQNDxxx----------- -------------------------------------------------- ELKKKYMIIENFIPSDEKIKLMSRFRYDDETDAWSLLPLEIEDAIPFKRP VNCDGDRRPISDFGRVAIKVGRSHRYHGENIVNLEMEAHARTTNDYLGPT VAPKIQAVLDEALKDEGDIDVDAAPLRLSQAxxxxxxxxxRDKDKHLxxS KIRGKKNMVIQTTQPVFPKARGLVPK------------------------ -------------------------------------------------- -------------------------------------------------- -------------------------------------- >Tbi -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ----------------------------------SRQEDLYEESIRPLVS SVLDGFNGTIFAYGQTGTGKTYTMEGPKNDPSQKGIIPKSFEQIFNYISR SSNMQYLVRASYLEIYQEDIR----------------------------- -------------------------------------------------- ----------DLLNKDPSKHLELREKPEIGVYVKDLSSFVCKSMNEIEHV MVVGNMNRSIGATNMNEHSSRSHAIFVVTIEMGATEASVKKLIRVGKLNL VDLAGSERQSKTGAS----------------------------------- -------------------------------------------------- ------------------------GNSKTVMVANIGPASYNYDESLTTLR YANRAKNIKNKPRVNEDPKDALLRQYQQEIARLKVLLAEKHKIVEMRAQA QNQKKEKESKKTQPTPDIPSDITEEELRRKIMNGEIIISPE-------MN QKLIEEIERKKQEVIRERKETEKLQAQLMFMESKLLSGGKNIVDHTNEQQ RALELRKQEIAERK------------------------------------ -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- --------------------------xxxxxxxxxxxx >Tte -------------------------------------------------- --------xxxxxxxxxxQxxHPGKYWHHAAQSTIEEWIPTGQxxxxxxx xxxxxxxxxxxxxxxxxxxxxxxxxxxxILALLWAVGLEQFDQLxxxxxG LxxxHDAG------------------------------------------ -------------------------------------------------- -------xVSDVAWxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx xxxxxxxxxxxxxx----------------------------------VI EVVSSRGVIEISHPKDSSKDSKKMFTFDAVYDWNSRQEDLYEESIRPLVS SVLDGFNGTIFAYGQTGTGKTYTMEGPKNDPSQKGIIPKSFEQIFNYISR SSNMQYLVRASYLEIYQEDIR----------------------------- -------------------------------------------------- ----------DLLNKDPSKHLELREKPEIGVYVKDLSSFVCKSMNEIEHV MVVGNMNRSIGATNMNEHSSRSHAIFVVTIEMGATEASVKKLIRVGKLNL VDLAGSERQSKTGASxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx x------------------------------------------------- -----------------------GGNSKTVMVANIGPASYNYDESLTTLR YANRAKNIKNKPRVNEDPKDALLRQYQQEIARLKVLLAEKHKIVEMRAQA QNQKKEKESKKTQPTPDIPSDITEEELRRKIMNGEIIISPE-------MN QKLIEEIERKKQEVIRERKETEKLQAQLMFMESKLLSGGKNIVDHTNEQQ RALELRKQEIAERKKREVEMRxxxxxQEANSMEFRETFTNLKQEAEVKTR KLKKLFSKLQATKLEMNDLTEEFNRDRRELELTQNDxxxLIGTRLIYDDY AYQHLISLRQVLSATETTRSANAAPFRLLPHPTNTTNVSFPPPPSSNFGT ELKKKYMIIENFIPSDEKIKLMSRFRYDDETDAWSLLPLEIEDAIPFKRP VNCDGDRRPISDFGRVAIKVGRSHRYHGENIVNLEMEAHARTTNDYLGPT VAPKIQAVLDEALKDEGDIDVDAAPLRLSQAxxxKxxxxxRDKDKHLxxS KIR----------------------xxxxxxxGxxxxxxxxxxxxxxxxM ITRxxxxxxxLQPQPEATLRLRTSIVLAQT----DRYWCLIYDLQVEPGH KVHQGYLGLHQGKTISCNQIQYNDNxxxxxxxxxxxxxxxxxxxxIPASV AWLxxxxxxxSSTAEDGEIDVRISxx------------ >Tms x------------------------------------xxxxxxxxxxxxx xxxxxxxxx----------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -----------------------------------------------xVI EVVSSRGVIEISHPKDSSKDSKKMFTFDAVYDWNSRQEDLYEESIRPLVS SVLDGFNGTIFAYGQTGTGKTYTMEGPKNDPSQKGIIPKSFEQIFNYISR SSNMQYLVRASYLEIYQEDIR----------------------------- -------------------------------------------------- ----------DLLNKDPSKHLELREKPEIGVYVKDLSSFVCKSMNEIEHV MVVGNMNRSIGATNMNEHSSRSHAIFVVTIEMGATEASVKKLIRVGKLNL VDLAGSERQSKTGAS----------------------------------- --------------------------GARLKEASKINLSLSALGNVISAL VDGKTTHIPYRDSKLTRILQDSLGGNSKTVMVANIGPASYNYDESLTTLR YANRAKNIKNKPRVNEDPKDALLRQYQQEIARLKVLLAEKHKIVEMRAQA QNQKKERESKKTQPTPDIPSDITEEELKRKIMNGEIIISPE-------MN QKLIEEIERKKQEVIRERKETEKLQAQLMFMESKLLSGGKNIVDHTNEQQ RALELRKQEIAERKKREVEMRxxxxxQEANSMEFRETFTNLKQEAEVKTR KLKKLFSKLQATKLEMNDLTEEFNRDRRELELTQNDxxx----------- -------------------------------------------------- ELKKKYMIIENFIPSDEKIKLMSRFRYDDETDAWSLLPLEIEDAIPLKRP VNCDGDRRPISDFGRVAIKVGRSHRYHGENIVNLEMEAHARTTNDYLGPT VAPKIQAVLDEALKDEGDIDVDAAPLRLSQAxxxKxxxxxRDKDKHLxxS KIRGKKNMVIQTTQPVFPKARGLVPK------------------------ -------------------------------------------------- -------------------------------------------------- -------------------------------------- >Tcm -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------MNEIEHV MVVGNMNRSIGATNMNEHSSRSHAIFVVTIEMGATEASVKKLIRVGKLNL VDLAGSERQSKTGAS----------------------------------- --------------------------GARLKEASKINLSLSALGNVISAL VDGKTTHIPYRDSKLTRILQDSLGGNSKTVMVANIGPASYNYDESLTTLR YANRAKNIKNKPRVNEDPKDALLRQYQQEIARLKVLLAEKHKIVEMRAQA QNQKKERESKKTQPTPDIPSDITEEELKRKIMNGEIIISPE-------MN QKLIEEIERKKQEVIRERKETEKLQAQLMFMESKLLSGGKNIVDHTNEQQ RALELRKQEIAERKKREVEMRxxxxxQEANSMEFRETFTNLKQEAEVKTR KLKKLFSKLQATKLEMNDLTEEFNRDRRELELTQNDxxx----------- -------------------------------------------------- ELKKKYMIIENFIPSDEKIKLMSRFRYDDETDAWSLLPLEIEDNIPFKRP VNCDGDRRPISDFGRVAIKVGRSHRYHGENIVNLEMEAHARTTNDYLGPT VAPKIQAVLDEALKDEGDIDVDAAPLRLSQAxxxxxxxxxRDKDKHLxxS KIRGKKNMVIQTTQPVFPKARGLVPK------------------------ -------------------------------------------------- -------------------------------------------------- -------------------------------------- >Tsi -------------------------------------------------- --------xx---------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------xxxxxxxxxxxVI EVVSSRGVIEISHPKDSSKDSKKMFTFDAVYDWNSRQEDLYEESIRPLVS SVLDGFNGTIFAYGQTGTGKTYTMEGPKNDPSQKGIIPKSFEQIFNYISR SSNMQYLVRASYLEIYQEDIR----------------------------- -------------------------------------------------- ----------DLLNKDPSKHLELREKPEIGVYVKDLSSFVCKSMNEIEHV MVVGNMNRSIGATNMNEHSSRSHAIFVVTIEMGATEASVKKLIRVGKLNL VDLAGSERQSKTGAS----------------------------------- --------------------------GARLKEASKINLSLSALGNVISAL VDGKTTHIPYRDSKLTRILQDSLGGNSKTVMVANIGPASYNYDESLTTLR YANRAKNIKNKPRVNEDPKDALLRQYQQEIARLKVLLAEKHKIVEMRAQA QNQKKERESKKTQPTPDIPSDITEEELKRKIMNGEIIISPEIILFIFQMN QKLIEEIERKKQEVIRERKETEKLQAQLMFMESKLLSGGKNIVDHTNEQQ RALELRKQEIAERKKREVEMRxxxxxQEANSMEFRETFTNLKQEAEVKTR KLKKLFSKLQATKLEMNDLTEEFNRDRRELELTQNDxxx----------- -------------------------------------------------- ELKKKYMIIENFIPSDEKIKLMSRFRYDDETDAWSLLPLEIEDNIPFKRP VNCDGDRRPISDFGRVAIKVGRSHRYHGENIVNLEMEAHARTTNDYLGPT VAPKIQAVLDEALKDEGDIDVDAAPLRLSQAxxxKxxxxxRDKDKHLxxS KIRGKKNMVIQTTQPVFPKARGLVPK------------------------ -------------------------------------------------- -------------------------------------------------- -------------------------------------- >Tps xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx------------ -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ------------------------------------------------VI EVVSSRGVIEISHPKDSSKDSKKMFTFDAVYDWNSRQEDLYEESIRPLVS SVLDGFNGTIFAYGQTGTGKTYTMEGPKNDPSQKGIIPKSFEQIFNYISR SSNMQYLVRASYLEIYQEDIR----------------------------- -------------------------------------------------- ----------DLLNKDPSKHLELREKPEIGVYVKDLSSFVCKSMNEIEHV MVVGNMNRSIGATNMNEHSSRSHAIFVVTIEMGATEASVKKLIRVGKLNL VDLAGSERQSKTGAS----------------------------------- --------------------------GARLKEASKINLSLSALGNVISAL VDGKTTHIPYRDSKLTRILQDSLGGNSKTVMVANIGPASYNYDESLTTLR YANRAKNIKNKPRVNEDPKDALLRQYQQEIARLKVLLAEKHKIVEMRAQA QNQKKERESKKTQPTPDIPSDITEEELKRKIMNGEIIISPE-------MN QKLIEEIERKKQEVIRERKETEKLQAQLMFMESKLLSGGKNIVDHTNEQQ RALELRKQEIAERKKREVEMRxxxxxQEANSMEFRETFTNLKQEAEVKTR KLKKLFSKLQATKLEMNDLTEEFNRDRRELELTQNDxxx----------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------- >Tdi xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx------------ -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ------------------------------------------------VI EVVSSRGVIEISHPKDSSKDSKKMFTFDAVYDWNSRQEDLYEESIRPLVS SVLDGFNGTIFAYGQTGTGKTYTMEGPKNDPSQKGIIPKSFEQIFNYISR SSNMQYLVRASYLEIYQEDIR----------------------------- -------------------------------------------------- ----------DLLNKDPSKHLELREKPEIGVYVKDLSSFVCKSMNEIEHV MVVGNMNRSIGATNMNEHSSRSHAIFVVTIEMGATEASVKKLIRVGKLNL VDLAGSERQSKTGAS----------------------------------- --------------------------GARLKEASKINLSLSALGNVISAL VDGKTTHIPYRDSKLTRILQDSLGGNSKTVMVANIGPASYNYDESLTTLR YANRAKNIKNKPRVNEDPKDALLRQYQQEIARLKVLLAEKHKIVEMRAQA QNQKKERESKKTQPTPDIPSDITEEELKRKIMNGEIIISPE-------MN QKLIEEIERKKQEVIRERKETEKLQAQLMFMESKLLSGGKNIVDHTNEQQ RALELRKQEIAERKKREVEMRxxxxxQEANSMEFRETFTNLKQEAEVKTR KLKKLFSKLQATKLEMNDLTEEFNRDRRELELTQNDxxx----------- -------------------------------------------------- ELKKKYMIIENFIPSDEKIKLMSRFRYDDETDAWSLLPLEIEDAIPFKRP VNCDGDRRPISDFGRVAIKVGRSHRYHGENIVNLEMEAHARTTNDYLGPT VAPKIQAVLDEALKDEGDIDVDAAPLRLSQAxxxKxxxxxRDKDKHLxxS KIRGKKNMVIQTTQPVFPKARGLVPK------------------------ -------------------------------------------------- -------------------------------------------------- -------------------------------------- >Tpa -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ----------------------------------VLLAEKHKIVEMRAQA QNQKKEKESKKTQPTPDIPSDITEEELRRKIMNGEIIISPE-------MN QKLIEEIERKKQEVIRERKETEKLQAQLMFMESKLLSGGKNIVDHTNEQQ RALELRKQEIAERKKREVEMRxxxxxQEANSMEFRETFTNLKQEAEVKTR KLKKLFSKLQATKLEMNDLTEEFNRDRRELELTQNDxxx----------- -------------------------------------------------- ELKKKYMIIENFI------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -----------------------------xxxxxx--------------- -------------------------------------------------- -------------------------------------- >Tce -------------------------------------------------- --------xx---------------------------------------- -------------------------------------------------- -------xxxxxxxxxxxxxxxxxGKDHNSSPSGQARWFENDxxxxxxxx xVIVxxxxxxxxxxxxxxxxxxxxxxxxPLLTLVPPSGTADGGxxxxxxG xxxLKAGxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx------------ -----------------------------------------------xVI EVVSSRGVIEISHPKDSSKDSKKMFTFDAVYDWNSRQEDLYEESIRPLVS SVLDGFNGTIFAYGQTGTGKTYTMEGPKNDPSQKGIIPKSFEQIFNYISR SSNMQYLVRASYLEIYQEDIRSIQSTEDGLKYYNYQCNTGSFLKNFIKKV CGAQKLDLVGLEEEKRIESERKKQEQEDKEKIKIKEAKEALLRENLLEKQ ESEAIEDVLTNLLNKDPSKHLELREKPEIGVYVKDLSSFVCKSMNEIEHV MVVGNMNRSIGATNMNEHSSRSHAIFVVTIEMGATEASVKKLIRVGKLNL VDLAGSERQSKTGAS----------------------------------- --------------------------GARLKEASKINLSLSALGNVISAL VDGKTTHIPYRDSKLTRILQDSLGGNSKTVMVANIGPASYNYDESLTTLR YANRAKNIKNKPRVNEDPKDALLRQYQQEIARLKVLLAEKHKIVEMRAQA QNQKKERESKKTQPTPDIPSDITEEELKRKIMNGEIIISPE-------MN QKLIEEIERKKQEVIRERKETEKLQAQLMFMESKLLSGGKNIVDHTNEQQ RALELRKQEIAERKKRExxxxxxxxxQEANSMEFRETFTNLKQEAEVKTR KLKKLFSKLQATKLEMNDLTEEFNRDRRELELTQNDxxx----------- -------------------------------------------------- ELKKKYMIIENFIPSDEKIKLMSRFRYDDETDAWSLLPLEIEDAIPLKRP VNCDGDRRPISDFGRVAIKVGRSHRYHGENIVNLEMEAHARTTNDYLGPT VAPKIQAVLDEALKDEGDIDVDAAPLRLSQVxx----------------- --xGKKNMVIQTTQPVFPKARGLVPK------------------------ -------------------------------------------------- -------------------------------------------------- --------------------------------------