>Tge x------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- --------------------------------------xxxxxxxxxxxx xxxxxxxx------------------------------------------ ---------------------------------------xNAAGxI---- -------------------------------------------------- ----------------AYNxxxxxxxxxxxIVGLTSPQTMKLLPNQGSKL NQK----------------------------------------------- -------------------------------------------------- -------------------------------------------------- --------------------VAVxxxDGVLQVFSxxxxxxQLSFKTLPGP GISRLELGGAIGTVQDKIFVSSGNEVRGYTKKGKLFLAFDTNLTEPIKSM --------------------------------NVSGSNLLICGKHVYNQY HDCKDANSYLCGDEINDVISFPYEK-----------------TNRLVPVL ACEDSSLRVLDRSKVMHTVEIDSSPTVLHLYRNDGGDTGDQVLYGTVDGR VGVLQVG------RWLVNNELHRGGILCMDCYDITGDGMMDLLIGRQDGS IEVYSIEDDGEDEDGKETRKFGFxxxxxxxxxxxxxxxxxxxxx------ -------------------------------------------------- -------------------------------------------------- ------------------------------xxxxxxxxxxxxxxxxSKSL QSQTxNESVTSIQGGIFGSSGCDEILATTYTx------------------ -------------------------------------------------- ------------------------------------------xxxxxxxx xxxxxxxxxxxxxxxxxxxRTEIEEIEQKVIKERERYQDATQDKSDGLSA IPYISIND------------------------------------------ -------------------------------------------------- ----------------------------------------------xMxx xxxxxxYSLMLxxxxxxDNVLIQSDVPLDLLDVERNSAVxxxxxxxxxVS YYSIPLPYMSFKPHYIVKIIVYSFIARSLSHSIVSFQxxxYxxxxxxxxx xxxxxxxxxRTxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx xxxx------------xxxxxxxxxxxxxxxxxxKPTTGEKATFIFVSTF LGxMLxCTYWx-----------------------------xxxA------ -----------------------------RYKPFAAIRQLxGFPTNTKGx xxLVGTKxxxxxxxxxxxxxxxxxDILTKEATKKKIKLEILCAVNDDSIP HTLKLLHPKLEAQLELAKKITLLEALKxxEAHEGGSSCLIxEYRDILEKE KLLQAEYKKQPAHLDRLY----------------------------xMIT DMYIDKHKFKGANVKGKVPQLLEVLDKYELNKLLNFFDQx >Tps -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------xxxxxxxxxxxIVGLTAPQTMKLLPNQGSKL NQK----------------------------------------------- -------------------------------------------------- -------------------------------------------------- --------------------VAVxxxDGVLQVFSxxxxxxQLSFKTLPGP GISRLELGGAIGTVQDKIFVSSGNEVRGYTKKGKLFLAFDTNLTEPIKSM --------------------------------NVSGSNLLICGKHAYNQY HDCKDANSYLCGDEINDVISFPYEK-----------------TNRLVPVL ACEDSSLRVLDRSKVMHTVEIDSSPTVLHLYRNDGGDTGDQVLYGTVDGR VGVLQVGRTGVRNRWLVNNELHRGGILCMDCYDITGDGMMDLLIGRQDGS IEVYSIEDDGEDEDGKETRKFGF--------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ---TxNESVTSIQGGIFGSSGCDEILATTYTx------------------ -------------------------------------------------- ------------------------------------------xxxxxxxx xxxxxxxxxxxxxxxxxxxRTEIEEIEQKVIKERERYQDATQDKSDGLSA IPYISIND------------------------------------------ -------------------------------------------------- ----------------------------------------------Kxxx xxxxxxYSLMLxxxxxxDNVLIQSDVPLDLLDVERNSAVxxxxxxxxx-- -------------------------------------xxxYxxxxxxxxx xxxxxxxxxRTxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx xxxxRPYNILGLKGAFxxxxxxxxxxxxxxxxxxKPTTGEKATFIFVSTF LGxMLxCNYW---------------------------------------- -------------------------------------------------- ------KxxxxxxxxxxxxxxxxxDILTKEATKKKIKLEILCAVNDDSIA HTLKLLHPKLEAQLELAKKITLLEALKxxEAHEGDSSCLIxEYRDILEKE KLLQAEYKKQPAHLDRLYxxxxxxxxxxxxxxxxxxxxxxxxxxxx---- ---------------------------------------- >Tdi -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------xxxxxxxxxxxIVGLTAPQTMKLLPNQGSKL NQKFVMTVLIDKGKD----------------------------------- -------------------------------------------------- -------------------------------------------------- -SRLVPTLPVRHQAVLINTDVAVxxxDGVLQVFSxxxxxxQLSFKTLPGP GISRLELGGAIGTVQDKIFVSSGNEVRGYTKKGKLFLAFDTNLTEPIKSM --------------------------------NVSGSNLLICGKHAYNQY HDCKDANSYLCGDEINDVISFPYEK-----------------TNRLVPVL ACEDSSLRVLDRSKVMHTVEIDSSPTVLHLYRNDGGDTGDQVLYGTVDGR VGVLQVGRTGVRNRWLVNNELHRGGILCMDCYDITGDGMMDLLIGRQDGS IEVYSIEDDGEDEDGKETRKFGF--------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ---TxNESVTSIQGGIFGSSGCDEILATTYTxxxxxxxxxxxxxxxxxxx xxxxxxxxxxxxxxxxx-------xPLSEPIxxxxxxxxxxxxxxxxxxx xxxxxxxxxxxxx------x-----------------xxxxx-------- -------------------RTEIEEIEQKVIKERERYQDATQDKSDGLSA IPYISIND----------------------------------------x- ----xxxx---------------xxxxxxxxxxxxxxxTxxTSETFENHT xxxxxxKKxxxxxxxxxxxxxxxxxxxxxxxxxxSSSMNMAKMSVPKxxx xxxxxxYSLMLxxxxxxDNVLIQSDVPLDLLDVERNSAVxxxxxxxxxVS YYSIPLPYMSFKPHRIVKIIVYLFNARSLSHSIVLFQxxxYxxxxxxxxx xxxxxxxxxxTxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx xxxx------SLKGAFxxxxxxxxxxxxxxxxxxKPTTGEKATFIFVSTx xxxMLxxxxxxx---------------------xxGPLRLR--------- -------------------------------------------------- ------KxxxxxxxxxxxxxxxxxDILTKEATKKKIKLEILCAVNDDSIA HTLKLLHPKLEAQLELAKKITLLEALKxxEAHEGDSSCLIxEYRDILEKE KLLQAEYKKQPAHLDRLY----------------------------xMIT DMYIDKHKFKGANVKGKVPQLLEVLDKYELNKLLNFFDQ- >Tsi xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxHTK RYCL-----------------------------------------VWTGQ NSEDVHYQVLENSFMSGVLFEGNKSVQHDxxYIIxxxxxxxxxxxxxxxx xxxxxxxxxxxxxxxxxxxxxxxxTxxxxxxxxxxxxxxxxxxxxxxxxx xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxKHHEEx----------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ----------------AYNxxxxxxxxxxxIVGLTAPQTMKLLPNQGSKL NQK----------------------------------------------- -------------------------------------------------- -------------------------------------------------- --------------------VAVxxxDGVLQVFSxxxxxxQLSFKTLPGL GISRLELGGAIGTVQDKIFVSSGNEVRGYTKKGKLFLAFDTNLTEPIKSM --------------------------------NVSGSNLLICGKHAYNQY HDCKDANSYLCGDEINDVISFPYEK-----------------TNRLVPVL ACEDSSLRVLDRSKVMHTVEIDSSPTVLHLYRNDGGDTGDQVLYGTVDGR VGVLQVGRTGVHNRWLVNNELHRGGILCMDCYDITGDGMMDLLIGRQDGS IEVYSIEDDGEDEDSKETRKFGF--------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ---TxNESVTSIQGGIFGSSGCDEILATTYTxxxxxxxxxxxxxxxxxxx xxxxxxxxxxxxxxxxxxxxxxxxxPLSEPIxxxxxxxxxxxxxxxxxxx xxxxxxxxxxxxxxxxxxxx-----------------xxxxx-------- -------------------RTEIEEIEQKVIKERERYQDATQDKSDGLSA IPYISIND----------------------------------------x- ----xxxx---------------xxxxxxxxxxxxxxxTxxTGETFENHT xxxxxxRKxxxxxxxxxxxxxxxxxxxxxxxxxx-------------xxx xxxxxxYSLMLxxxxxxDNVLIQSDVPLDLLDVERNSAVxxxxxxxxx-- -------------------------------------xxxYxxxxxxxxx xxxxxxxxxRTxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx xxxx------------xxxxxxxxxxxxxxxxxxKPTTGEKATFIFVSTF LGxMLxCNYWxxxxCFFFSISFTLMIxINLLPCR---------------- -------------------------------------------------- ------KxxxxxxxxxxxxxxxxxDILTKEATKKKIKLELLCAVNDDSIA HTLKLLHPKLEAQLELAKKITLLEALKxxEAHEGDSSCLIxEYRDILEKE KLLQAEYKKQPAHLDRLY----------------------------xMIT DMYIDKHKFKGANVKGKVPQLLEVLDKYELNKLLNFFDQx >Tce xx------------------------------------------------ -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ----------------------------------------------TNQY HDCKDANSYLCGDEINDVISFPYEK-----------------TNRLVPVL ACEDSSLRVLDRSKVMHTVEIDSSPTVLHLYRNDGGDTGDRVLYGTVDGR VGVLQVGRTGVRNRWLVNNELHRGGILCMDCYDITGDGMMDLLIGRQDGS IEVYSIEDDGEDEDGKETRKFGF--------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ---TxNESVTSIQGGIFGSSGCDEIxxTTYTx------------------ -------------------------------------------------- ------------------------------------------xxxxxxxx xxxxxxxxxxxxxxxxxxxR------------------------------ -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------xxxxxxx xxxxxxxxxxxxxxxxxxxxxxxxxxxxxx-------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ---------------------------------------- >Tcm x------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ---------------------------------------------xxxxx xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx xxxxxxxSVANVSETVAYNxxxxxxxxxxxIVGLTAPQTMKLLPNQGSKL NQK----------------------------------------------- -------------------------------------------------- -------------------------------------------------- --------------------VAVxxxDGVLQVFSxxxxxxQLSFKTLPGP GISRLELGGAIGTVQDKIFVSSGNEVRGYTKKGKLFLAFDTNLTEPIKSx --------------------------------NVSGSNLLICGKxAYNQY HDCKDANSYLCGDEINDVxxxPYEK-----------------TNRLVPVL ACEDSSLRVLDRSKVMHTVEIDSSPTVLHLYRNDGGDTGDQVLFGTVDGR VGVLQVGRTGVHNRWLVNNELHRGGILCMDCYDITGDGMMDLLIGRQDGS IEVYSIEDDGEDEDGKETRKFGF--------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ---xxNESVTSIQGGIFGxxxxxEIxxxxxxx------------------ -------------------------------------------------- ------------------------------------------xxxxxxxx xxxxxxxxxxxxxxxxxxxRxEIEEIEQKVIKERERYQDATQDKSDGLSA IPYISINDKxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx- -------------------------------------------------- --------------------xxxxxxxxxxxxxxxxxxxxxxxxxxx--- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ---------------------------------------- >Tpa xxx----------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------xxxxxxx------------------------------ -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -----------GTVQDKIFVSSGNEVRGYTKKGKLFLAFDTNLTEPIKSM xxRVVGDSISLAPSPLLGYGLVIREKNTSFFRNVSGSNLLICGKHVYNQY HDCKDANSYLCGDEINDVISFPYEK-----------------TNRLVPVL ACEDSSLRVLDRSKVMHIVEIDSSPTVLHLYRNDGGDTGDQVLYGTVDGR VGVLQVG------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ---------------------------------------- >Tms xx------------------------------------------------ ---xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxVLTLIQQVWTGQ DSEDVHYQVLEDSFMGGVLFEGN--------------------------- -------------------------------------------------- -------------------NRFTL------------------------P- LYCRSxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxRIAG------ -------------------------------------------------- --------------xxAYNxxxxxxxxxxxIVGLTAPQTMKLLPNQGSKL NQK-----------ExxxxxxxxxxxxxxPRAGGVVSDLRSRKGGRIEGR EGWRTLQTRGEERFETHIEHVAPSRSSAKTETELFYPSSLLAEHVVEPRC RQARTRLQSVRSxWRERxxxxxxxPRVxPVGCxxxxxxxQCKSLHRCPSW LSEL----------------VAVxxxDGVLQVFSxxxxxxQLSFKTLPGP GISRLELGGAIGTVQDKIFVSSGNEVRGYTKKGKLFLAFDTNLTEPIKSM --------------------------------NVSGSNLLICGKHAYNQY HDCKDANSYLCGDEINDVISFPYEK-----------------TNRLVPVL ACEDSSLRVLDRSKVMHTVEIDSSPTVLHLYRNDGGDTGDRVLYGTVDGR VGVLQVGRTGVHNRWLVNNELHRGGILCMDCYDITGDGMMDLLIGRQDGS IEVYSLEDDGEDEDSKETRKFGF--------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ---TxNESVTSIQGGIFGSSGCDEILATTYT------------------- -----------------------------------------xxxxxxxxx xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx-xx-------- -------------------LTEIEEIEQKVIKERERYQDATQDKSDGLSA IPYISIND----------------------------------------xx xxxxxxxxxxxxxxxxxxxxxxxxxx------------------------ -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ------------------------------------xxxx >Tbi xx------------------------------------------------ -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------xxxxxxxxxxxxxxxxxTNRLVPVL ACEDSSLRVLDRSKVMHTIEIDSSPTVLHLYRNDGGDTGDQVLYGTVDGR VGVLQVGRTGVRNRWLVNNELHRGGILCMDCYDITGDGMMDLLIGRQDGS IEVYSIEDDGEDEDGKETRKFGFx-----------xxxxxxxxxxxxxxx xxxxxxxxx---------------------------------xxxxxxxx xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx xxxxxxxxxxxxxxxxxxxxxxx--------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ---------------------------------------- >Tte xx------------------------------------------------ -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- --------------------------xxxxxxxKHREE------------ -------------------------------------------------- ---------------------------------------------I---- -------------------------------------------------- ----------------AYNxxxxxxxxxxxIVGLTSPQTMKLLPNQGSKL NQK----------------------------------------------- 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xxxxxxYSLMLxxxxxxDNVLIQSDVPLDLLDVERNSAVxxxxxxxxxVS YYSIPLPYMSFKPHYIVKIIVYSFVARSLSHSIVLFQxxxYxxxxxxxxx xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx xxxx------------xxxxxxxxxxxxxxxxxxKPTTGEKATFIFVSTx xxxMLxxxxxx-----------------------------x--------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ----------------------------------------