>Tge -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ------------------------------------------------DD DDDD-----DDMSDGERVEQVGGNGSPSNGVVDEQSNPQTFEMYDSERD- ----GQNSSV---------------xxxxxxxxxSTLLVYSENKVKGELV VEQILVETQNVQAVVNKPIKPMIEEMEIAVTPN--------TEATMNLTS HVDKAENKREVKQINNKSDQACILDETMDSSKDIESESEMLVKSTKETFH YLTNDLLNNDKKTKVFDGPKTVKSKTSIEGNFI--------DIKDSDVKN SERMLRLVDITPQLTQQIGREDVEAKPGNAFEKEDSSETTKNLINVKHTN VRSGTSVESQEDLDNQTRSGLELESGKVEQEAGPQIEIETKTCENVPVEP TISNESDGPECMVAESRTEMISENSTSELEPCLVSERANSEPMEIDKVET ACTGKRLINVEEETEVKTENQNVGDDS-RQDVKx---------------- ------------DINLKDSQSQDVGASKDIQEQDVSTLPSDGSDCVTKEK EHSVSEESVEKLLVVSGEVDCQHVLDETEDKTETTYSTCNGPVVDMDIAG LGTSVDIGANQDAEDRVHAAGQSRKRRRVSTPLPEMDAKRWRMESVKLDF DPVQEH-------------------------------------------- -----------------RYWCIWGLPVDRGQEDSLIGWQRVLADLVRYTL QKSTIVSEEETTAEEKNIFEELVKYRDVLSTLVLKRGC------------ -------------------------------------------------- -------------------------------------------------- --------------------------------xCKDDSVCVCTKx----- -------------------------------------------------- -------------------------------- >Tbi -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ----------------------------------------EExxxEExDD DDDD-----DDMSDGERVEQVGGNGSPSNGVVDEQSNPQTFEMYDSERD- ----GQNSSVIRAKGENETTTNVVG---------STMLVYSENKVKGENV IEQILVETQNVQAVVNKPIKPMIEEMEIAVTPN--------TEVAMNHTS HVDKAENKREVKEINNKSDKACILDETMDSSKDIESESEMLVKSTKETFH YLTNDLLNNDKKTKVLDGPKTVKSKTSIEGDFI--------DIKDSDVKN SERMPRLVDITPQLTQQIRREDVEAKPGTAFEKEDSSETTKNLINVKHTN VRPGTSVESQEDLDNQTRSGLELESGKVEQEPGPPIEIETKTCENVPAEQ TISNESDGP-----ESRTEMISKNSTSELEPCLVSERANSEPMEIDKVET ACTGKRLINVEEEMEVKTENQNVGDDS-RQEMKx---------------- ------------DINLKDSQSQDVGGSKDIQEQDVSTLPSDGSDCVTKEK EHSVSEESVEKLLVVSGEVDCQHVLDETEDKTETTYSTCNGPVVDMDITG LGTSVDIGANQDAEDRVHAAGQSRKRRRVSTPLPEIDAKRWRMESVKLDF DPVQEH-------------------------------------------- -----------------RYWCIWGLPVDRGQEDSLIGWQRVLADLVRYTL QKSTIVSEEETTAEEKNIFEELVKYRDVLSTLxxxxGC------------ -------------------------------------------------- -------------------------------------------------- --------------------------------xCKGDSVCVCTKQ----- -------------------------------------------------- -------------------------------- >Tte --------------------------------------------MEFEDR IKRYKKLPFETLNGLESSDVSDDIKTAVNQDFDKFVERVATFGVLKWGAY PxxxxxxxxxxWQSEMKDYMIYCTxxxxxxxxxxYLKEPDDWTDxxxxxx xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxSLxKx-- ------------------IALEHGALQLIVKNILKVPLTEESLSALILSL CGWGPTTSHNVLSCDFCKRQVGLWNFITIQDEPTLADDYLCILNSPGSCT DEPLSILESSPIQDVDMQLTDPQTTEGSELHEDATEKEESSFIDDQYD-- --YGHYDENQDSCDDENEGSVEQYTIENNDEENLDSDQRESAMKGYQDPN LMIDNINLVPDNFSEQDCEDFPGIEPEDGTTSVDTKVSTKPNLLEGExxx xxxLELTSGSEESDGSLEDEED---EEDYPS----xDEEAEDEEMYMEEG NIRFMTDEKGLIQKYRKDEESFEDxxx--------------------xxx xxxxxxDDPEGxxExxxxxxxxxxx-xxxxxxxxxxxxxxEEGTEEEDDD DDDD-----DDMSDGERVEQVGGNGSPSNGVVDEQSNPQTFEMYDSERD- ----GQNSSVIRAKGENETTTNVVG---------STMLVYSENKVKGENV IEQILVETQNVQAVVNKPIKLMIEEMEIAVTPN--------TEVAMNHTS HVDKAENKREVKEINNKSDKACILDETMVSSKDIESESEMLVKSTKETFH YLTNDLLNNDKKTKVFDGPKT----------------------------- -------------LTQQIRREDVEAKPGTAFEKEDSSETTKNLINVKHTN VRPGTSVESQEDLDNQTRSGLELESGKVEQEPGPPIEIETKTCENVPAEQ TISNESDGPECMEAESRTEMISKNSTSELEPCLVSERANSEPMEIDKVET ACTGKRLINVEEEMEVKTENQNVGDDS-RQDVKxxxxLKDSQSQAWEDEI NLKEGxxxxxxEDINLKDSQSQDVGGSKDIQEQDVSTLPSDGSDCVTKEK EHSVSEESVEKLLVVSGEVDCQHVLDETEDKTETTYSTCNGPVVDMDITG LGTSVDIGANQDAEDRVHAAGQSRKRRRVSTPLPEIDAKRWRMESVKLDF DPVQEH-------------------------------------------- -----------------RYWCIWGLPVDRGQEDSLIGWQRVLADLVRYTL QKSTIVSEEETTAEEKNIFEELVKYRDVLSTLVLKRGCxxxxxxxxNKxx xxxLITPWWSQASxxxxxxxxxxxxxxxxxxxxxxxxxxxxLLYKEPFES EVFHLEVLxxxxxATSTxPYSRSALEFPxxxxxxxxxxxxV--------- ------------------------------Exx----------------- -------------------------------------------------- -------------------------------- >Tpa -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -----------------------------------------------M-- ------------------IALEHGALQLIVKNILKVPLTEESLSALILSL CGWGPTTSHNVLSCDFCKRQVGLWNFITIQDEPTLADDYLCILNSPGSCT DEPLSILESSPIQDVDMQLTDPQTTEGSELHEDATEKEESSFIDDQYDYG HEYGHYDENQDSCDDENEGSVEQYTIENNDEENLDSDQRESEMKSYQDAN LMIDNITLVPDNFSEQDCEDFPGIEPEDGTTSVDVKVSTKPNLLEGExxx xxxxxLTSGSEESDGSLEDEED---EEDYPSDGxEDDEEAEDEEMYMEEG NIRFMTDEKGLIQKYRKDEESFEDxxxxxxxxxxxxxxxxxxExxxxx-- ---DEKDDPEGxxExxxxxxxxxxxxxxxxxxxxxxxxxxEExxEEExDD DDDx-----DDMSDGERVEQVGGNGSPSNGVVDEQSNPQTFEMYDSERD- ----GQNSSVLRTKSENETTTNVVD---------RTMLVYSENKVKGENV VEQILVETQNVQAVVNKPIKPMIEEMEIAVTPN--------TEVAMNHTS HVDKAENKREVEEINNKSDKACILDETMDSSKDIESESAMLVKSTKETFH YLTNDLLNNDKKTKVFDGPKTVKSKTSIEGNFI--------DTKDx---- -------------------------------------------------- ----TSVESQEDLDNQTRSGLELESGKVEQEADPQIEIETKTCENVPVEP TISNESDGPECMVAESRTEMISENSTSELEPCLVSERANSEPMEIDKVET ACTGKRLINVEEETEVKTENQNVGDDS-RQDVKxxxxFKDSQSQASEDEI NLKDSxxxxxxEDINLKDSQSQDVGASKDIQEKDVSTLPSDGSDCVTKEK EHSVSEESVEKLLVVSGEVDCQHVLDEMEDKTETTYSTCNGPVVDLDIAG LGTSVDIGANQDAEDRVHAAGQSRKRRRVSTPLPEMDAKRWRMESVKLDF DPV----------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ---------------------------------------xxxxxxxxxxx xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx----------------- -------------------------------------------------- -------------------------------- >Tms -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -----------------------------------------SHVDINHTS HVDKAENKLEV-----KPDK------TMDSSKDIERESEMLVKSTKETFH YLTNDLVNNDEKTKVFDGPKTVKSKTSIEGNFIDxxxSTLLDIKESDINN SERMPRLVNTTPQLTQQIRREEVEAKLGTVFEKEESSETNKSLIHVKHTK VGLRTSVESQEDLDTQTRSELELESLKVEQEANPQIEIETKSCENVPVEP TISNESDDTKCMEAESRTETVSENCTSELEPCLVSERAKSEPMEIDNVEI TCTNKRIITVEEETEVKTENQNVGDDSxGQDLK----------------- -----------EDNSLKDSKGQDV-------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------xx----- -------------------------------------------------- -------------------------------- >Tce -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- --------------------xxxxxxxxx-----------xxxxxxxxxx xxxxx---xxxMSDGERIEQVGGNGSPSNGVVDEQSNPQTFEMYDSERDx QTSLGQNSSVLRTESENETIKNVVD---------STMLVYSENK-----G VEQTLVETQNVPAVVKKPIKPMIEEMEIAVTPNxxxxxxxxxxxxxxHTS HVDKAENKLEV-----KPDK------TMDSSKDIERESEMLVKSTKETFH YLTNDLVNNDEKTKVFDGPKTVKSKTSIEGNFIxxxxxxxxDIKESDINN SERMPRLVNTTPQLTQQIRREEVEAKLGTVFEKEESSETNKSLIHVKHTK VGLRTSVESQEDLDTQTRSELELESLKVEQETNPQIEIETKSCENVPVEP TISNESDDTKCMEAESRTETVSENCTSELEPCLVSERAKSEPMEIDNVEI TCTNKRIITVEEETEVKTENQNVGDDSxGQDLK----------------- -----------EDNSLK--------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------- >Tsi -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -----------------------------------------------xxx xxxxxxxxxxxxxxxxQxIALEHGALQLIVKNILKVPLTEESMSALVLAL CGWGPTTSHNVLSCDFCKRQVGLWNFITIQDEPTLADDYLCILNSPGSCS DEPLSVLESSPIQDVDMQLDGSQVAEGSEPHEDASEKEESSFIGEQYDYD HEYGHYDENQDSCDDANEGSVEQYAIENNDEENLDSDQHESASKGYQDAN LLIDNITLVPDNFSEQDCEGFPGIEPEDGATSVDVKVSKEPNLLEGGNGx xxxLELTSGSEESDGSLEDEEDxxxEEDYPSDG-EEDEEVEDEEIYMEEG HIRYMTDEKRLIHKYGKDEESFxxxxxx---------------------- -------------------------------------------------- -----------------------------------------xMYDSERDx QTSLGQNSSVLGTERENETVKNVVD---------GTMLVYSENKGKGEIG VEQTLVETQNDQAVVNKPIKPMMEEMEVAVTPH--------TEVAINHTS LVDKTENKREVKEINNKPDK------TTDSSKDIESESETLVKSTKETFH YLTNDSVNNDEKTKVFDGPKTVKSKTSTEGIFIDxxxATLLDIKESDIKN SERTPRLVNTTPQLTQPIRREEVEAKLGTAFEKEDSSETSKSLTHVEHTK VGLRTSVESREDLDTQTRSESELEGVKVEQEANPQIEMETKTCENVPVEP TISNGSDDTKCTEAESRTEIVSENSTSELEPCLVTERAKSEPMEIDNVET ACTDKRIITAEEETEVKTENQDVGDDG-GQDVK----------------- -----------EDISLKDSQSQDVGGRKDVQEQAVSAPPSDRSDSVTKEK EHSVSEECVEKLLVISGEVDCQHVLDEGEDKTETTYSTCNGPVVDMDIAG L------GADQGAEDRGQTTGQSRKRRRVSTPLPEIDTKRWRME------ -------------------------------------------------- ------------------YWCIWGLPVDQGQEDSLMGWQRVLADLVRYTL QKSTVVSDEETTAQEK---------------------------------- -------------------------------------------------- -------------------------------------------------- ---------------------------------------------xxxxx xxxxxxxxxxxxxxxxxxxxLIKTITVILAFExxxxxxxxxxxxNKDGRG KDSKxxxxxxxxxxSPMASLxxxxxxxxxxxx >Tps EVALRVSLLSLMSSDRMKPRSGxxxxxxxxxxxxxxxxxxxxxSx----- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ------------------IALEHGALQLIVKNILKVPLTEESMSALVLAL CGWGPTTSHNVLSCDFCKRQVGLWNFITIQDEPTLADDYLCILNSPGSCS DEPLSVLESSPIQDVDMQLDGSQVAEGSEPHEDASEKEESSFIGEQYDYD HEYGHYDENQDSCDDANEGSVEQYAIENNDEENLDSDQHESASKGYQDAN LLIDNITLVPDNFSEQDCEGFPGIEPEDGATSVDVKVSKEPNLLEGGNGx xxxLELTSGSEESDGSLEDEEDxxxEEDYPSDG-EEDEEAEDEEIYMEEG NIRYMTDEKRLIRKYGKDEESFEDxxxxxxxxxxxxxxxxxxxx------ -------------------------------------------------- ------------------------------------------------Dx QTSLGQNSSVLGTESENETVKNVVD---------GTMLVYSENKGKGEIG VEQTLVETQNDQAVVNKPIKPMMEEMEIAVTPN--------TEVAINHTS HVDKAENKREVKEINNKPDK------TVDSSKDIESESETLVKSTKETFH YLTNDLVNNDEKTKVFDGPKTVKSKTSTEGNFIDxxxATLLDIKESDIKN SERTPRLVNTTPQLTQPIRREEVEAKLGTAFEKEDSSETSKSLTHVEHTK VGLGTSVESREDLDTQTRSESELEGVKVEQEANPQIEMETKTCENVPVEP TISNGSDDTKCTEAESRTEIVSENSTSELEPCLVTERAKSEPMEIDNVET ACTDKRIITAEEETEVKTENQDV---x-GQDVK----------------- -----------E-----DSQSQDVGDSKDVQEQVDSTLPSDGSDSVTKEK EHSVSEESVEKLLVISGEVDCQHVLDEGEDKTETTYSTCNGPVVDMDIAG L------GADQGAEDRGQTTGQSRKRRRVSTPLPEIDTKRWRME------ -------------------------------------------------- ------------------YWCIWGLPVDQGQEDSLMGWQRVLADLVRYTL QKSTVVSDEETTAQEKNIFEELVKYRDVLSTLVxxxxx------------ -------------------------------------------------- -------------------------------------------------- --------------------------------xxEADSVCVCTxx----- -------------------------------------------------- -------------------------------- >Tdi -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ------------------------------------------MSALVLAL CGWGPTTSHNVLSCDFCKRQVGLWNFITIQDEPTLADDYLCILNSPGSCS DEPLSVLESSPVQDVDMQLDGSQVAEGSEPHQDASEKEESSFIGEQYDYD HEYGHYDENQDSCDDANEGSVEQYAIENNDEENLDSDQHESASKGYQDAN LLIDNITLVPDNFSEQDCEGFPGIEPEDGATSVDVKVSKEPNLLEGGxxx xxxxxLTSGSEESDGSLEDEEDxxxEEDYPSDG-EEDEEVEDEEIYMEEG HIRYMTDEKRLIHKYGKDEESFEDxxxx--xxxxxxxxxxxxExGHPD-- ---DDKDEPEG-xxxxxxxxxxxxxxxxxx----------xxxxxxxxxx xxxxxxxxxDDMSDGERIEQVGGNGSPSNGVVDEQSNPQTFEMYDSERDx QTSLGQNSSVLGTESENETVKNVVD---------GTMLVYSENKGKGEIG VEQTLVETQNDQAVVNKPIKPMMEEMEIAVTPH--------TEVAINHTS HVDKTENKREVKEINNKPDK------TTDSSKDIESESETLVKSTKETFH YLTNDLVNNDEKTKVFDGPKTVKSKTSTEGNFIDxxxATLLDIKESDIKN SERTPRLVNTTPQLTQPIRREEVEAKLGTAFEKEDSSETSKSLTHVEHTK VGLGTSVESREDLDTQTRSESELEGVKVEQEANPQIEMDTKTCENVPVEP TISNGSDDTKCTEAESRTEIVSENSTSELEPCLVTERAKSEPMEIDNVET ACTDKRIITAEEETEVKTENQDVGDDG-GQDVK----------------- -----------E-----DSQSQDVGGSKDVQEQVDSTLPSDGSDSVTKEK EHSVSEECVEKLLVISGEVDCQHVLDEGEDKTETTYSTCNGPVVDMDIAG L------GADQGAEDRGQTTGQSRKRRRVSTPLPEIDTKRWRME------ -------------------------------------------------- ------------------YWCIWGLPVDQGQEDSLMGWQRVLADLVRYTL QKSTVVSDEETTAQEK---------------------------------- -------------------------------------------------- -------------------------------------------------- ---------------------------------------------xxxxx xxxxxxxxxxxxxxxxxxx------------------------------- -------------------------------- >Tcm -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ------------------------------------------MSALVLAL CGWGPTTSHNVLSCDFCKRQVGLWNFITIQDEPILADDYLCILNSPGSCS DEPLSVLESSPIQDVDMQLDDSQVAEGSEPHEDASEKEESSFIGEQYDYD HEYGHYDENQDSCDDANEGSVEQYAIENNDEENLDSDQHESASKGYQDAN LLIDNITLVPDNFSEQDCEGFPGIEPEDGATSVD---------------- -----LTSGSEESDGSLEDEEDxxxEEDYPSDG-EEDEEVEDEEIYMEEG HIRYMTDEKRLIHKYGKDEESFxxxxxx--xxxxxxxxxxxxxx------ -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ------------------------------------------EVAINHTS LVDKTENKREVKEINNKPDK------TTDSSKDIESESETLVKSTKETFH YLTNDSVNNDEKTKVFDGPKTVKSKTSTEGNFIDxxxATLLDIKESDIKN SERTPRLVNTTPQLTQPIRREEVEAKLGTAFEKEDSSETSKSLTHVEHTK VGLGTSVESRQDLDTQTRSESELEGVKVEQEANPQIEMETKTCENVPVEP TISNGSDDTKCTEAESRTEIVSENSTSELEPCLVTERAKSEPMEIDNVET ACTDKRIITAEEETEVKTENQDVGDDG-GQDVK----------------- -----------EDISLKDSQSQDVGGSKDVQEQAVSAPPSDGSDSVTKEK EHSVSEECVEKLLVISGEVDCQHVLDEGEDKTETTYSTCNGPVVDMDIAG L------GADQGAEDRGQTTGQSRKRRRVSTPLLEIDTKRWRMESVKLDF DPVQEHxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx xxxxxxxxxLVCLHxxxxxxCIWGLPxxxxxxxxLxxWQRVLADLVRYTL QKSTVVSDEETTAQEKNIFEELVKYRDVLSTLVLKRGC------------ -------------------------------------------------- -------------------------------------------------- --------------------------------xCKADSVCVCTKx----- -------------------------------------------------- --------------------------------