>Tge ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------MSVRFMCPTCGIQFFTADKLTEHLARLPKEGFVCETCNNKFCTLGMLNAHKR VHSRGKFAASICEVCGKHLPNKSSYNRHKQIHSGEKNFKCGYCGKAFVRKHALKVHMYSH PLKEDYTCMECSISYEDIEGLQRHVRIAHKDEDETLLCNICKEHVEVPLFIDHYKACHLL KEDEMLSRRLSVVTCQICSKVFSTPATLNRHSKLHNPLFSRASTCEICQETIVGRRNVIS HARTHYDESNMPEKYQRIIRSLVRDQKYRKTAAQKSYICEYCGREFNKAINLQIHIRRHT GEKPYMCQMCGMAFYTRQQLSIHIRTHTGERPYTCKAAGCGKTFSSPAAIYMHRKIHSDA QMYRCHICEKTFAKRLTYIGHVRAHTNERPFKCSQCPGAFTLRSKLNLHMNKHKQEAERE ALTCSDCNTTFATVEDLDAHCA-----DQCYIT--------------------------- ------------------------------------------------------------ ----------------------------------------------------VHTY---- ----------------------------EEGEELDID----------------------- ------------------------------------------------------------ --------------------GQAQVIVLNPED---------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -------FADIENSFIEEEDG------L >Tpa ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----MLSRRLSVVTCQICSKVFSTPATLNRHSKLHNPLFSRASTCEICQETIVGRRNVIS HARTHYDESNMPEKYQRIIRSLVRDQKYRKTAAQKSYICEYCGREFNKAINLQIHIRRHT GEKPYMCQMCGMAFYTRQQLSIHIRTHTGERPYTCKAAGCGKTFSSPAAIYMHRKIHSDA QMYRCHICEKTFAKRLTYIGHVRAHTNERPFKCSQCPGAFTLRSKLNLHMNKHKQEAERE ALTCSDCNTTFATVEDLDAHCA-----DQCYIT--------------------------- ------------------------------------------------------------ ----------------------------------------------------VHTY---- ----------------------------EEGEELDID----------------------- ------------------------------------------------------------ --------------------GQAQVIVLNPED---------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -------FADIENSFIEEEDG------L >Tbi ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------MSVRFMCPTCGIQFFTADKLTEHLARLPKEGFVCETCNNKFCTLGMLNAHKR VHSRGKFAASICE----------------------------------------------- ----------------------RHVRIAHKDEDETLLCNICKEHVEVPLFIDHYKACHLL KEDEMLSRRLSVVTCQICSKVFSTPATLNRHSKLHNPLFSRASTCEICQETIVGRRNVIS HARTHYDESNMPEKYQRIIRSLVRDQKYRKTAAQKSYICEYCGREFNKTINLQIHIRRHT GEKPYMCQMCGMAFYTRQQLSIHIRTHTGERPYTCKAAGCGKTFSSPAAIYMHRKIHNDA QMYRCHICEKTFAKRLTYIGHVRAHTNERPFKCSQCSGAFTLRSKLNLHMNKHKQEAERE ALTCSDCNTTFATVEDLDAHCA-----DQCYIT--------------------------- ------------------------------------------------------------ ----------------------------------------------------VHTY---- ----------------------------EEGEELDID----------------------- ------------------------------------------------------------ --------------------GQAQVIVLNPED---------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -------FADIENSFIEEEDG------L >Tcm ------------------------------------------------------------ -------------------------------------------------MAENRPVQTTA STAAEEVCRLCGKTKVDLVSIYSEEASAKNILQKMKDLLNINVTPQDKLSKRVCHPCVTQ LTLCDGMVEFFMKNQEVLKKKYPEDTQPGELSKDLSTDADSGEPSEACAVDGDEATLSPV EEPPNINTNASTD----------------------------------------------- ------------------------------------------------------------ ----------------------------------------GGAEQGPERTKMSIVVLDPE SLGVSINQDMLFALHGLDATLPVACDFCESEFDDLEKFDIHMASHKEVRFFSCQLCTNTY MSWSNLVAHRKACHGGSVLSCEECSERRYHPDLGPVNYAVGDFPVGCEECGAGFHSLNEL YRHFRDQANHNTVRRVKIAKGLQESKSLPSRTLQESKSLPFKGLQESKSL-PSKGLQKSL QETKRLPSNSRQENKRLPSKDLQKIKRLLSRSHRESKSLPFKG-----------LQETKS LLSKSLQESKSLPSKGRKENKSLP-------------------SKSKEEKVGQPRLAKPV KKKPTFRAMSVRFMCPTCGIQFFTADKLTEHLARLPKEGFVCETCNNKFCTLGMLNAHKR VHSRGKFAASICE----------------------------------------------- ----------------------RHVRIAHKDEDETLMCNICKEHVEVPLFIDHYKACHLL KEDEMLSRRLSAVTCQICSKVFSTPATLNRHSKLHNPLFSRANTCEICQEIIVGRRNIIS HARTHYDESNMPEKYQRISRSLVRDQKYRKTAAQKSYICEYCGREFNKTINLQIHIRRHT GEKPYMCQMCGMAFYTRQQLSIHIRTHTGERPYTCKAAGCGKTFSSPAAIYMHRKIHSDA QMYRCHICEKTFTKRLTYIGHVRAHTNERPFRCSQCPGAFTLRSKLNLHMNKHKQEAERE ALTCSDCNTTFATVEDLDVHCA-----DQCYIT--------------------------- ------------------------------------------------------------ ----------------------------------------------------VHTY---- ----------------------------EEGEELDID----------------------- ------------------------------------------------------------ --------------------GQAQVIVLNPED---------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -------FADIESSFIEEEDG------L >Tms ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------MSVRFMCPTCGIQFFTADKLTEHLARLPKEGFVCETCNNKFCTLGMLNAHKR VHSRGKFAASICEVCGKHLPNKSSYNRHKQIHSGEKNFKCGYCGKAFVRKHALKVHMYSH PLKEDYSCLECSISYEDIEGLQRHVRIAHKDEDETLMCNICKEHVEVPLFIDHYRACHLL KEDEMLSRRLSAVTCQICSKVFSTPATLNRHSKLHNPLFSRASTCEICEEIIVGRRNIIS HARTHYDESNMPEKYQRIIRSLVRDQKYRKTAAQKSYICEYCGREFNKTINLQIHIRRHT GEKPYMCQMCGMAFYTRQQLSIHIRTHTGERPYTCKAAGCGKTFSSPAAIYMHRKIHNDA QMYRCHICEKTFTKRLTYIGHVRAHTNERPFRCSQCPGAFTLRSKLNLHMNKHKQEAERE ALTCSDCNTTFATVEDLDVHCA-----DQCYIT--------------------------- ------------------------------------------------------------ ----------------------------------------------------VHTY---- ----------------------------EEGEELDID----------------------- ------------------------------------------------------------ --------------------GQAQVIVLNPED---------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -------FADIESSFNEEEDG------L >Tdi ------------------------------------------------------------ -------------------------------------------------MAENRPVQTTT STAAE------------------------------------EVTPQDKLSKRVCHPCVTQ LTLCDGMVEFFMKNQEVLKKKYPEDTQPGELSKDLSTDADSGEPSEACAVDGDEAALSPV EEPPNINTNVSTDG---------------------AARLFVPARTVMRGHGRLRGSGLEL --------------------------------------------------------VAVL SVLGLLRA----RRGHCDAITREHGDEVFLTYICVMELTKGGVEQGPERTKMSIVVLDPE SLGVSINQDMLFALHGLDATLPVACDFCESEFDDLEKFDIHMASHKEVRFFSCQLCTNTY MSWSNLVAHRKACHGGSVLSCEECSERRYHPDLGPVNYAVGDFPVGCEECGAGFHSLNEL YRHFRDQANHNTVRRVKIAK---------------------------------------- --TKKLPSKSCQENKRLPSKDLQKIKRLLSRSHRESKSLLFKG-----------LQETKS LSSKSLQESKSLPSKGRKENKSLPFK-----------VCDEPNSKSKEEKVGQPRLAKTV KKKPTFRAMSVRFMCPTCGIQFFTADKLTEHLARLPKEGFVCETCNNKFCTLGMLNAHKR VHSRGKFAASICEVCGKHLPNKSSYNRHKQIHSGEKNFKCGYCGKAFVRKHALKVHMYSH PLKEDYSCLECSISYEDIEGLQRHVRIAHKDEDETLMCNICKEHVEVPLFIDHYRACHLL KEDEMLSRRLSAVTCQICSKVFSTPATLNRHSKLHNPLFSRSSTCEICQEIIVGRRNIIS HARTHYDDSNMPEKYQRISRSLVRDQKYRKTAAQKSYICEYCGREFNKTINLQIHIRRHT GEKPYMCQMCGMAFYTRQQLSIHIRTHTGERPYTCKAAGCGKTFSSPAAIYMHRKIHSDA QMYRCHICEKTFTKRLTYIGHVRAHTNERPFRCSQCPGAFTLRSKLNLHMNKHKQEAERE ALTCSDCNTTFATVEDLDVHCA-----DQCYIT--------------------------- ------------------------------------------------------------ ----------------------------------------------------VHTY---- ----------------------------EEGEELDID----------------------- ------------------------------------------------------------ --------------------GQAQVIVLNPED---------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -------FADIETSFIEEEDG------L >Tce ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------MGXDADSGEPSEACAVDGDEATLSPV EEPPNINTNVSTD----------------------------------------------- ------------------------------------------------------------ ----------------------------------------GGAEQGPERTKMSIVVLDPE SLGVSINQDMLFALHGLDATLPVACDFCESEFDDLEKFDIHMASHKEVRFFSCQLCTNTY MSWSNLVAHRKACHGGSVLSCEECSERRYHPDLGPVNYAVGDFPVGCEECGAGFHSLNEL YRHFRDQANHNTVRRVKIAK---------------------------------------- ------------------------------------------------------------ -------------------------------------VCDEPNSKSKEEKVGQPRLAKTV KKKPTFRAMSVRFMCPTCGIQFFTADKLTEHLARLPKEGFVCETCNNKFCTLGMLNAHKR VHSR-------------------------------------------------------- ----------------DIEGLQRHVRIAHKDEDETLMCNICKEHVEVPLFIDHYRACHLL KEDEMLSRRLSAVTCQICSKVFSTPATLNRHSKLHNPLFSRASTCEICEEIIVGRRNIMS HARTHYDESNMPEKYQRIIRSLVRDQKYRKTAAQKSYICEYCGREFNKTINLQIHIRRHT GEKPYMCQMCGMAFYTRQQLSIHIRTHTGERPYTCKAAGCGKTFSSPAAIYMHRKIHNDA QMYRCHICEKTFTKRLTYIGHVRAHTNERPFRCSQCPDAFTLRSKLNLHMNKHKQEAERE ALTCSDCNTTFATVEDLDVHCA-----DQCYIT--------------------------- ------------------------------------------------------------ ----------------------------------------------------VHTY---- ----------------------------EEGEELDID----------------------- ------------------------------------------------------------ --------------------GQAQVIVLNPED---------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -------FADIESSFNEEEDG------L >Tte ---VKEGFGNQINLCRYRGLNPGPPAQKFDTLPLDHQIRTTVEAWHSTHSQFVIYTRLVR GEGRVWQSDKSVPGQRIEPRTLSTEVRHITPKPPEADEENSVGNNVKGKMAENRPVQTTA STAAEGVCRLCGKTKVDLISIYSEEASAKNILQKMKDLLNINVTLQDKLSKRVCHSCVTQ LTLCDGMVEFFMKNQEVLKKKYPEETEPGELSKDLSTDADSGEPNEACAVDGDEATLSPV EDPPNINTNVSTDG------------------------LNFPLRVHPHPNKKL------- -------------------------SSQKRNNMVQGNKAVCSLLLTRPSETITPQHIAAL SNIGLKRGPRFISRRQCRAAPTEQKE--------------EGAEQGVERTKMSI-VLDPE SLGVSINQDMLFALHGLDATLPVACDFCESEFDDLEKFDIHMASHKEVRFFSCQLCTNTY MSWSNLVAHRKACHGGSVLSCEECSERRYHPDLGPVNYAVGDFPVGCEECGAGFHSLNEL YRHFRDQANHNTVRRVKIAK---------------------------------------- ------------------------------------------------------------ -------------------------------------VCDEPNSKSKEEKVGQPRLAKTV KKKPTFRAMSVRFMCPTCGIQFFTADKLTEHLARLPKEGFVCETCNNKFCTLGMLNAHKR VHSRGKFAASICEVCGKHLPNKSSYNRHKQIHSGEKNFKCGYCGKAFVRKHALKVHMYSH PLKEDYSCLECSISYEDIEGLQRHVRIAHKDEDETLLCNICKEHVEVPLFIDHYKACHLL KEDEMLSRRLSVVTCQICSKVFSTPATLNRHSKLHNPLFSRASTCEICQETIVGRRNVIS HARTHYDESNMPEKYQRIIRSLVRDQKYRKTAAQKSYICEYCGREFNKTINLQIHIRRHT GEKPYMCQMCGMAFYTRQQLSIHIRTHTGERPYTCKAAGCGKTFSSPAAIYMHRKIHNDA QMYRCHICEKTFAKRLTYIGHVRAHTNEWPFKCSQCSGAFTLRSKLNLHMNKHKQEAERE ALTCSDCNTTFATTEELAKHTARLEDSSQCYVCWECKMKLCDFLSLLKHERMHLNAVKKL IKPSKHSFMCPNCDMQFLTGQQRKEHLKKLNDSDLCHACDECKKKFCNLSSLLLHESRHQ DVSTSNNYLCEICGKVIQTRSGYSRHLLTHSRDKTFACDWCDKSFIYKKSLDIHMYSHPL RVDYSCFDCSLAFTDFSGLKSHMKAAHTDETRQLSCNTCGKSWDVPAFLDHYKLCHLEFE SKIADKRRKNVTCPKCSKVFSQPAAVRRHLKLHNAGKKHHTCEVCGAVIVKRNEMIEHAK SHYGDTLPEKYINMMKMLEKSRAQALKYNRKDCICEYCGMKFNKNANLQMHLRRHTGDKA HKCELCGRGFHTKQRLKFHVELHSGERIYSCAKCPREFSNKQEYEQHNKLHTVKARDIQC PHCEQKLSKKQTFLAHLRLHTGERPYVCNLCPKRFISKTSLYTHNKLKHPPELVADNCTQ EMSSGFMYKDMQIVVIPEEEGNEMSGVL >Tsi -------FND-------------------------------------------------- --------------------------------PGPSREQ--------------------- -----------------------------------------EPTIQD------------- -------------------------------------------PSRE------------- QEP--------------------------------------------------------- --------------------------------TIQGS----------------------- ------------SR--------EQ----------------EPTVQGP------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------SKEAVKRTRLPSKGLQKIKSLPSKGLQ--------------- -ETKRLPSNSRQENKRLPSKDLQKIKRLLSRSHRESKSLPFKG-----------LQETKS LLSKSLQESKSLPSKGRKENKSLPSK---------------------------PRLAKPV KKKPTFRAMSVRFMCPTCGIQFFTADKLTEHLARLPKEGFVCETCNNKFCTLGMLNAHKR VHSRGKFAASICE----------------------------------------------- ------------------------------------------------------------ --------------------VFSTPATLNRHSKLHNPLFSRASTCEICQEIIVGRRNIIS HARTHYDESNMPEKYQRISRSLVRDQKYRKTAAQKSYICEYCGREFNKTINLQIHIRRHT GEKPYMCQMCGMAFYTRQQLSIHIRTHTGERPYTCKAAGCGKTFSSPAAIYMHRKIHSDA QMYRCHICEKTFTKRLTYIGHVRAHTNERPFRCSQCPGAFTLRSKLNLHMNKHKQEAERE ALTCSDCNTTFATVEDLDD--S-----SQCYVCWECKMKLCDFLSLLKHERMHLNAVKKL IKPSKHSFMCPNCGMQFLTGQQRKEHLKKLNDSDLCHACDECKKKFCNLSSLLLHESSHQ DVSTSNNYLCEICGKVIQTRSGYSRHLLTHSRDKTFACDWCDKSFIYKKSLDIHMYSHPL RVDYSCFDCSLAFTDFSGLKSHMKAAHTDETKQLTCNTCGKSWVVPAFLDHYKLCHLEFE SKIADKRRKNVTCPKCSKVFSQPAAVRRHLKLHNAGKKHHTCEVCGAVIVKRNEMIEHAK SHYGDTLPEKYINMMKMLEKSRAQALKYNRKDCICEYCGMKFNKNANLQMHLRRHTGDKA HKCELCGRGFHTKQRLKFHVELHSGERIYSCAKCPREFSNKQEYEQHNKLHTVKARDIQC PHCEQKLSKKQTFLAHLRLHTGERPYVCNLCPKRFISKTSLYTHNKLKHPPERVAVNCTQ EMSSGFMYKDMQIVVIPEEEGNEMSGVL >Tps QTLVFEKHDDR----RTRGV---------------------------------------- -----------------------TLLSSLCVAPAQSEDQLSY------KMAENRPVQTTA STAAE------------------------------------EVTPQDKLSKRVCHPCVTQ LTLCDGMVEFFMKNQEVLKKKYPEDTQPGELSKDLSTDADSGEPSEACAVDGDEATLSPV EEPPNINTNVSTDGPREKISVELCRVSSTVLCVFSAARLFIPARTIMRGHGRLRGSGLEL VAVLFVLGLLRARRGHCDAITREHGDEQNCNNTVQGNKAVCSLLV--------------- ----------FLSRIMALQLVLQR----------------KGVEQGPERTKMSIVVLDPE SLGVSINQDMLFALHGLDATLPVACDFCESEFDDLEKFDIHMASHKEVRFFSCQLCTNTY MSWSNLVAHRKACHGGSVLSCEECSERRYHPDLGPVNYAVGDFPVGCEECGAGFHSLNEL YRHFRDQANHNTVRRVKIAKGLQESKSLPSKGLQESKSLLSKGLQKIESIKPS------- -KTKKLPSKSCQENKRLPSKDLQKIKRLLSRSHRESKSLLFKGLQETKSLSSKSLQETKS LSSKSLQESKSLPSKGRKENKSLPSKGRKENKSLPFKVCDEPNSKSKEEKVGQPRLAKTV KKKPTFRAMSVRFMCPTCGIQFFTADKLTEHLARLPKEGFVCETCNNKFCTLGMLNAHKR VHSRGKFAASICE----------------------------------------------- ------------------------------------------------------------ --------------------VFSTPATLNRHSKLHNPLFSRSSTCEICQEIIVGRRNIIS HARTHYDDSNMPEKYQRISRSLVRDQKYRKTAAQKSYICEYCGREFNKTINLQIHIRRHT GEKPYMCQMCGMAFYTRQQLSIHIRTHTGERPYTCKAAGCGKTFSSPAAIYMHRKIHSDA QMYRCHICEKTFTKRLTYIGHVRAHTNERPFRCSQCPGAFTLRSKLNLHLNKHKQEAERE ALTCSDCNTTFATVEDLDD--S-----SQCYVCWECKMKLCDFLSLLKHERMHLNAVKKL IKPSKHSFMCPNCGMQFLTGQQRKEHLKKLNDSDLCHACDECKKKFCNLSSLLLHESSHQ DVSTSNNYLCEICGKVIQTRSGYSRHLLTHSRDKTFACDWCDKSFIYKKSLDIHMYSHPL RVDYSCFDCSLAFTDFSGLKSHMKAAHTDETRQLTCNTCGKSWDVPAFLDHYKLCHLEFE SKIADKRRKNVTCPKCSKVFSQPAAVRRHLKLHNAGKKHHTCEVCGAVIVKRNEMIEHAK SHYGDTLPEKYINMMKMLEKSRAQALKYNRKDCICEYCGMKFNKNANLQMHLRRHTGDKA HKCELCGRGFHTKQRLKFHVELHSGERIYSCAKCPREFSNKQEYEQHNKLHTVKARDIQC PHCEQKLSKKQTFLAHLRLHTGERPYVCNLCPKRFISKTSLYTHNKLKHPPERVAVNCTQ EMSSGFMYKDMQIVVIPEEEGNEMSGVL