>Tge -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ------------MSVRFMCPTCGIQFFTADKLTEHLARLPKEGFVCETCN NKFCTLGMLNAHKRVHSRGKFAASICEVCGKHLPNKSSYNRHKQIHSGEK NFKCGYCGKAFVRKHALKVHMYSHPLKEDYTCMECSISYEDIEGLxRHVR IAHKDEDETLLCNICKEHVEVPLFIDHYKACHLLKEDEMLSRRLSVVTCQ ICSKVFSTPATLNRHSKLHNPLFSRASTCEICQETIVGRRNVISHARTHY DESNMPEKYQRIIRSLVRDQKYRKTAAQKSYICEYCGREFNKAINLQIHI RRHTGEKPYMCQMCGMAFYTRQQLSIHIRTHTGERPYTCKAAGCGKTFSS PAAIYMHRKIHSDAQMYRCHICEKTFAKRLTYIGHVRAHTNERPFKCSQC PGAFTLRSKLNLHMNKHKQEAEREALTCSDCNTTFAT------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ------------------------------VEDLDAHCxxxxxxxxxxxx xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxL >Tpa -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- --------------------------------------MLSRRLSVVTCQ ICSKVFSTPATLNRHSKLHNPLFSRASTCEICQETIVGRRNVISHARTHY DESNMPEKYQRIIRSLVRDQKYRKTAAQKSYICEYCGREFNKAINLQIHI RRHTGEKPYMCQMCGMAFYTRQQLSIHIRTHTGERPYTCKAAGCGKTFSS PAAIYMHRKIHSDAQMYRCHICEKTFAKRLTYIGHVRAHTNERPFKCSQC PGAFTLRSKLNLHMNKHKQEAEREALTCSDCNTTFAT------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ------------------------------VEDLDAHCxxxxxxxxxxxx xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxL >Tbi -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ------------MSVRFMCPTCGIQFFTADKLTEHLARLPKEGFVCETCN NKFCTLGMLNAHKRVHSRGKFAASICE----------------------- ----------------------------------------------RHVR IAHKDEDETLLCNICKEHVEVPLFIDHYKACHLLKEDEMLSRRLSVVTCQ ICSKVFSTPATLNRHSKLHNPLFSRASTCEICQETIVGRRNVISHARTHY DESNMPEKYQRIIRSLVRDQKYRKTAAQKSYICEYCGREFNKTINLQIHI RRHTGEKPYMCQMCGMAFYTRQQLSIHIRTHTGERPYTCKAAGCGKTFSS PAAIYMHRKIHNDAQMYRCHICEKTFAKRLTYIGHVRAHTNERPFKCSQC SGAFTLRSKLNLHMNKHKQEAEREALTCSDCNTTFAT------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ------------------------------VEDLDAHCADQCYITxxxxx xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxL >Tms -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ------------MSVRFMCPTCGIQFFTADKLTEHLARLPKEGFVCETCN NKFCTLGMLNAHKRVHSRGKFAASICEVCGKHLPNKSSYNRHKQIHSGEK NFKCGYCGKAFVRKHALKVHMYSHPLKEDYSCLECSISYEDIEGLxRHVR IAHKDEDETLMCNICKEHVEVPLFIDHYRACHLLKEDEMLSRRLSAVTCQ ICSKVFSTPATLNRHSKLHNPLFSRASTCEICEEIIVGRRNIISHARTHY DESNMPEKYQRIIRSLVRDQKYRKTAAQKSYICEYCGREFNKTINLQIHI RRHTGEKPYMCQMCGMAFYTRQQLSIHIRTHTGERPYTCKAAGCGKTFSS PAAIYMHRKIHNDAQMYRCHICEKTFTKRLTYIGHVRAHTNERPFRCSQC PGAFTLRSKLNLHMNKHKQEAEREALTCSDCNTTFAT------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ------------------------------VEDLDVHCxxxxxxxxxxxx xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxL >Tdi -------------------------------------------------- -------------------------------------------------- ----------------------------------------MAENRPVQTT TSTAAEE------------------------------------VTPQDKL SKRVCHPCVTQLTLCDGMVEFFMKNQEVLKKKYPEDTQPGELSKDLSTDA DSGEPSEACAVDGDEAALSPVEEPPNINTNVSTDx--------------- ------AARxxxxxxxxxxGHGRLRGSGLELVAVLSVLGLLRARRGHCDA ITRxxGxx--xxxxxxxxxELTKG-------------------------- -------------------------------------------------- -------------GVEQGPERTKMSIVVLDPESLGVSINQDMLFALHGLD ATLPVACDFCESEFDDLEKFDIHMASHKEVRFFSCQLCTNTYMSWSNLVA HRKACHGGSVLSCEECSERRYHPDLGPVNYAVGDFPVGCEECGAGFHSLN ELYRHFRDQANHNTVRRVKIAK---------------------------- -------------------------------------------------- ------------------------------------TKKLPSKSCQENKR LPSKDLQKIKRLLSRSHRESKSLLFKG-----------LQETKSLSSKSL QESKSLPSKGRKENKSLP-----------xxVCDEPNSKSKEEKVGQPRL AKTVKKKPTFRAMSVRFMCPTCGIQFFTADKLTEHLARLPKEGFVCETCN NKFCTLGMLNAHKRVHSRGKFAASICEVCGKHLPNKSSYNRHKQIHSGEK NFKCGYCGKAFVRKHALKVHMYSHPLKEDYSCLECSISYEDIEGLxRHVR IAHKDEDETLMCNICKEHVEVPLFIDHYRACHLLKEDEMLSRRLSAVTCQ ICSKVFSTPATLNRHSKLHNPLFSRSSTCEICQEIIVGRRNIISHARTHY DDSNMPEKYQRISRSLVRDQKYRKTAAQKSYICEYCGREFNKTINLQIHI RRHTGEKPYMCQMCGMAFYTRQQLSIHIRTHTGERPYTCKAAGCGKTFSS PAAIYMHRKIHSDAQMYRCHICEKTFTKRLTYIGHVRAHTNERPFRCSQC PGAFTLRSKLNLHMNKHKQEAEREALTCSDCNTTFAT------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ------------------------------VEDLDVHCxxxxxxxxxxxx xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxL >Tcm -------------------------------------------------- -------------------------------------------------- ----------------------------------------MAENRPVQTT ASTAAEEVCRLCGKTKVDLVSIYSEEASAKNILQKMKDLLNINVTPQDKL SKRVCHPCVTQLTLCDGMVEFFMKNQEVLKKKYPEDTQPGELSKDLSTDA DSGEPSEACAVDGDEATLSPVEEPPNINTNASTD---------------- -------------------------------------------------- -----------------------G-------------------------- -------------------------------------------------- -------------GAEQGPERTKMSIVVLDPESLGVSINQDMLFALHGLD ATLPVACDFCESEFDDLEKFDIHMASHKEVRFFSCQLCTNTYMSWSNLVA HRKACHGGSVLSCEECSERRYHPDLGPVNYAVGDFPVGCEECGAGFHSLN ELYRHFRDQANHNTVRRVKIAKxxxxxKSLPSRTLQESKS---------- -------------------------------------------------- -------------LPFKGLxESKSLxxKGLQKSLQETKRLPSNSRQENKR LPSKDLQKIKRLLSRSHRESKSLPFKG-----------LQETKSLLSKSL QESKSLPSKGRKENKSLP-------------------SKSKEEKVGQPRL AKPVKKKPTFRAMSVRFMCPTCGIQFFTADKLTEHLARLPKEGFVCETCN NKFCTLGMLNAHKRVHSRGKFAASICx----------------------- ----------------------------------------------RHVR IAHKDEDETLMCNICKEHVEVPLFIDHYKACHLLKEDEMLSRRLSAVTCQ ICSKVFSTPATLNRHSKLHNPLFSRANTCEICQEIIVGRRNIISHARTHY DESNMPEKYQRISRSLVRDQKYRKTAAQKSYICEYCGREFNKTINLQIHI RRHTGEKPYMCQMCGMAFYTRQQLSIHIRTHTGERPYTCKAAGCGKTFSS PAAIYMHRKIHSDAQMYRCHICEKTFTKRLTYIGHVRAHTNERPFRCSQC PGAFTLRSKLNLHMNKHKQEAEREALTCSDCNTTFAT------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ------------------------------VEDLDVHCxxxxxxxxxxxx xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxL >Tce -------------------------------------------------- -------------------------------------------------- ----------------------------------------xxx------- -------------------------------------------------- ------------------------------------------------DA DSGEPSEACAVDGDEATLSPVEEPPNINTNVSTD---------------- -------------------------------------------------- -----------------------G-------------------------- -------------------------------------------------- -------------GAEQGPERTKMSIVVLDPESLGVSINQDMLFALHGLD ATLPVACDFCESEFDDLEKFDIHMASHKEVRFFSCQLCTNTYMSWSNLVA HRKACHGGSVLSCEECSERRYHPDLGPVNYAVGDFPVGCEECGAGFHSLN ELYRHFRDQANHNTVRRVKIAK---------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------VCDEPNSKSKEEKVGQPRL AKTVKKKPTFRAMSVRFMCPTCGIQFFTADKLTEHLARLPKEGFVCETCN NKFCTLGMLNAHKRVHSR-------------------------------- ----------------------------------------DIEGLxRHVR IAHKDEDETLMCNICKEHVEVPLFIDHYRACHLLKEDEMLSRRLSAVTCQ ICSKVFSTPATLNRHSKLHNPLFSRASTCEICEEIIVGRRNIMSHARTHY DESNMPEKYQRIIRSLVRDQKYRKTAAQKSYICEYCGREFNKTINLQIHI RRHTGEKPYMCQMCGMAFYTRQQLSIHIRTHTGERPYTCKAAGCGKTFSS PAAIYMHRKIHNDAQMYRCHICEKTFTKRLTYIGHVRAHTNERPFRCSQC PDAFTLRSKLNLHMNKHKQEAEREALTCSDCNTTFAT------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ------------------------------VEDLDVHCxxxxxxxxxxxx xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxL >Tte xxxxxxxxIxxxxxxGLxPGPPAQKFDTLPLDHQIRTTVEAWHSTHSQFx xxxxxVRGEGRVWQxxxxxxxxxxxxxxxxxxxxxxxxKPPEADExNSVG NNVKG----------------------------------KMAENRPVQTT ASTAAEGVCRLCGKTKVDLISIYSEEASAKNILQKMKDLLNINVTLQDKL SKRVCHSCVTQLTLCDGMVEFFMKNQEVLKKKYPEETEPGELSKDLSTDA DSGEPNEACAVDGDEATLSPVEDPPNINTNVSTD---------------- -------------------------------------------------- -----------------------xxxxxxxxxxxxxxKLSSQKRNxxxxx xxxxCSLL------------xxxxxxxxTPQHIAALSNIGLKRGxxxxxx xxxxxxxxxxxxxGAEQGVERTKMSI-VLDPESLGVSINQDMLFALHGLD ATLPVACDFCESEFDDLEKFDIHMASHKEVRFFSCQLCTNTYMSWSNLVA HRKACHGGSVLSCEECSERRYHPDLGPVNYAVGDFPVGCEECGAGFHSLN ELYRHFRDQANHNTVRRVKIAK---------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------VCDEPNSKSKEEKVGQPRL AKTVKKKPTFRAMSVRFMCPTCGIQFFTADKLTEHLARLPKEGFVCETCN NKFCTLGMLNAHKRVHSRGKFAASICEVCGKHLPNKSSYNRHKQIHSGEK NFKCGYCGKAFVRKHALKVHMYSHPLKEDYSCLECSISYEDIEGLxRHVR IAHKDEDETLLCNICKEHVEVPLFIDHYKACHLLKEDEMLSRRLSVVTCQ ICSKVFSTPATLNRHSKLHNPLFSRASTCEICQETIVGRRNVISHARTHY DESNMPEKYQRIIRSLVRDQKYRKTAAQKSYICEYCGREFNKTINLQIHI RRHTGEKPYMCQMCGMAFYTRQQLSIHIRTHTGERPYTCKAAGCGKTFSS PAAIYMHRKIHNDAQMYRCHICEKTFAKRLTYIGHVRAHTNEWPFKCSQC SGAFTLRSKLNLHMNKHKQEAEREALTCSDCNTTFATxxxxxxxxxRxxD SxxxxxxxxxxxKLCDFLSLLxxxxxxxxxxxxxxxxxxxxxxCPxxxxx xxxxxxxKEHxKKLNDSDLxxxxxxxKKKFCNLSSLLLHESRHQDVSTSN NYLCEICGKVIQTRSGYSRHLLTHSRDKTFACDWCDKSFIYKKxxxxxxx xxxxxVDYSCFDCSLAFTDFSGLKSHMKAAHTDETRQxxCNTCxxxxxxP AFLDHYKLCHLEFESKIADKRRKNVTCPKCSKVFSQPAAVRRHLKLHNAG KKHHTCEVCGAVIVKRNEMIEHAKSHYGDTLPEKYINMMKMLxxxxxxxx xxxxxxCICEYCGMKFNKNANLQMHLRRHTGDKAHKCELCGRGFHTKQRL KFHVELHSGERIYSCAKCPREFSNKQEYEQHNKLHTVKARDIQCPHCEQK LSKKQTFLAHLRLHTGERPYVCNLCPKRFISKTSLYTHNKLKHPPELVAD NCTQEMSSGFMxxxxxxxxxxxxxxNEMSGV------------------- ----------------------------------L >Tsi -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ---------------xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx xxxxxxxxxxxxxxxxxxxxxxKxxxxxx----xxxTKRLPSNSRQENKR LPSKDLQKIKRLLSRSHRESKSLPFKG-----------LQETKSLLSKSL QESKSLPSKGRKENKSLPxx---------------------------PRL AKPVKKKPTFRAMSVRFMCPTCGIQFFTADKLTEHLARLPKEGFVCETCN NKFCTLGMLNAHKRVHSRGKFAASxxx----------------------- -------------------------------------------------- -------------------------------------------------- ----VFSTPATLNRHSKLHNPLFSRASTCEICQEIIVGRRNIISHARTHY DESNMPEKYQRISRSLVRDQKYRKTAAQKSYICEYCGREFNKTINLQIHI RRHTGEKPYMCQMCGMAFYTRQQLSIHIRTHTGERPYTCKAAGCGKTFSS PAAIYMHRKIHSDAQMYRCHICEKTFTKRLTYIGHVRAHTNERPFRCSQC PGAFTLRSKLNLHMNKHKQEAEREALTCSDCNTTFATxxx-------xxx xxxxxxxxxxxxKLCDFLSLLxxxxxxxxxxxxxxxxxxxxxxCPxxxxx xxxxxxxKEHxKKLNDSDLxxxxxxxKKKFCNLSSLLLHESSHQDVSTSN NYLCEICGKVIQTRSGYSRHLLTHSRDKTFACDWCDKSFIYKKxxxxxxx xxxxxVDYSCFDCSLAFTDFSGLKSHMKAAHTDETKQxxCNTCxxxxxxP AFLDHYKLCHLEFESKIADKRRKNVTCPKCSKVFSQPAAVRRHLKLHNAG KKHHTCEVCGAVIVKRNEMIEHAKSHYGDTLPEKYINMMKMLxxxxxxxx xxxxxxCICEYCGMKFNKNANLQMHLRRHTGDKAHKCELCGRGFHTKQRL KFHVELHSGERIYSCAKCPREFSNKQEYEQHNKLHTVKARDIQCPHCEQK LSKKQTFLAHLRLHTGERPYVCNLCPKRFISKTSLYTHNKLKHPPERVAV NCTQEMSSGFMxxxxxxxxxxxxxxNEMSGV------------------- ----------------------------------L >Tps -------------------------------------------------- -------------------------------------------------- ----QTLVFEKHDDRRTRGVTLLSSLCVAxxxxEDQLSYKMAENRPVQTT ASTAAEE------------------------------------VTPQDKL SKRVCHPCVTQLTLCDGMVEFFMKNQEVLKKKYPEDTQPGELSKDLSTDA DSGEPSEACAVDGDEATLSPVEEPPNINTNVSTDxxxxxxxxxxCRVSST VLCVFSxxxxxxxxxxxxxGxxxxxxxGLELVAVLFVLGLLRAxxGHCDA ITREHGxxxxx---------------------------------xxxxQG NKAVCSLLxxxxxxxxxxxxxxxx-------------------------- -------------GVEQGPERTKMSIVVLDPESLGVSINQDMLFALHGLD ATLPVACDFCESEFDDLEKFDIHMASHKEVRFFSCQLCTNTYMSWSNLVA HRKACHGGSVLSCEECSERRYHPDLGPVNYAVGDFPVGCEECGAGFHSLN ELYRHFRDQANHNTVRRVKIAKxxxxxKSLPSKGLQESKxLLSKGxxKIE SIKxSKxxxxxxxxx----------------------------------- ---------------------------------------------QENKR LPSKDLQKIKRLLSRSHRESKSLLFKGxxxxxxxxxxxLQETKSLSSKSL QESKSLPSKGRKENKSLxxxxxxxxxxxxxxVCDEPNSKSKEEKVGQPRL AKTVKKKPTFRAMSVRFMCPTCGIQFFTADKLTEHLARLPKEGFVCETCN NKFCTLGMLNAHKRVHSRGKFAASICx----------------------- -------------------------------------------------- -------------------------------------------------- ----VFSTPATLNRHSKLHNPLFSRSSTCEICQEIIVGRRNIISHARTHY DDSNMPEKYQRISRSLVRDQKYRKTAAQKSYICEYCGREFNKTINLQIHI RRHTGEKPYMCQMCGMAFYTRQQLSIHIRTHTGERPYTCKAAGCGKTFSS PAAIYMHRKIHSDAQMYRCHICEKTFTKRLTYIGHVRAHTNERPFRCSQC PGAFTLRSKLNLHLNKHKQEAEREALTCSDCNTTFATxxx-------xxx xxxxxxxxxxxxKLCDFLSLLxxxxxxxxxxxxxxxxxxxxxxCPxxxxx xxxxxxxKEHxKKLNDSDLxxxxxxxKKKFCNLSSLLLHESSHQDVSTSN NYLCEICGKVIQTRSGYSRHLLTHSRDKTFACDWCDKSFIYKKxxxxxxx xxxxxVDYSCFDCSLAFTDFSGLKSHMKAAHTDETRQxxCNTCxxxxxxP AFLDHYKLCHLEFESKIADKRRKNVTCPKCSKVFSQPAAVRRHLKLHNAG KKHHTCEVCGAVIVKRNEMIEHAKSHYGDTLPEKYINMMKMLxxxxxxxx xxxxxxCICEYCGMKFNKNANLQMHLRRHTGDKAHKCELCGRGFHTKQRL KFHVELHSGERIYSCAKCPREFSNKQEYEQHNKLHTVKARDIQCPHCEQK LSKKQTFLAHLRLHTGERPYVCNLCPKRFISKTSLYTHNKLKHPPERVAV NCTQEMSSGFMxxxxxxxxxxxxxxNEMSGV------------------- ----------------------------------L