>Tge -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------VV----------------------- -------------------------------------------------- -------------------------------------------------- ----------GEVERRLYKGVDTGERLLRVKPNPGVDQLPPAVSLAGSKV KLRVLQPEEVAALGHAVPLWEQRCLWESSPRSLYQEAxxxxGxxxxxxxx xxxRAxx------------------------------------------- -------------------xGDLPLTTSPEPPTSSTQYGDDQRACSSSSD NSLNGDSRFKSHLNVRLKQPDTASTPNILPNTASLAPSQPPFFSTLPSTR KGPQWPTMDAEH-QVPRNPFSTDYQATLPSNARLSSSDSSALAGNANPFT Y-------xEYVLPSPGPNPSGGRIPHQTISGHVPPPVIAPGTPLTHRLA PNPSYPNPNAALISPTHKNLTAEKQLDALSPQSNSTPSSPINSRQQRLSK KAGGPPHARSFDETMPSSASPLLGRRVNISSPMTTHKKERMSRKTSGNSV SSQPNAEDEEVQPPSLAASTPTSQKKNSRKISVNVSEVHPQSNADASRCS SSSGQESPTKSDRRRRVSVYFNKKGGGRRDSNVMGNGTRSLSASRYGPGE GGEATTSDRERTNSVSSRTSSATGGGRRKLSKSSNRALDAGDNK------ ----xxxxxxxxxxxxHHHNPNLSESxxxxxxxxxxxxxxxQAPVL---- -------QxV >Tms -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- --------------------xx-------------xxxxxxxxxxxxxxx xxxxxxxxxxxxx-----------------xxxxxxxxxxxxxxxxxxxx xxxx---------------------------------------------- ---------------------------------NVKEVIDALETQLGDTG LRGGVRGVRAQSGECYICLSRQQEAQSLLRSGLGLRGHHLTLLDVSRDSL VVCLSGVPHHVTDTAVALLAASFGTVIDIIGSLFIILLETTLERKNTLDT VPTSADNKPFNATAGHYxxDYARASPEHSPGLGHPPQQGDGGHSKGQSVG LNQTGVxxxxxxxxxxxxxx-------xxxExxxxxxxxxxxxxxxxxxx xxxxxxxxxxGEVERRLYKGVDTGERLLRVKPNPGVDQLPPAVSLAGSKV KLRVLPPEEVAALGHA---------------------------------- -------------------------------------------------- --------------------GDLPLTTSPEPPTSSTQYGDDQRACSSSSD NSLNGDSRFKSHLNVRLKQPDTASTPNILPNTASLAPSQPPFFSTLPSTR KGPQWPTMDAEHQQVPRNPFSADYQATLPSNARLSSSDSSALAGNANPFT YPAHPNFDSEYVLPSPGPNPSGGRIPHQTISGHVPPPVIAPGTPLTHRPT PAPSYLNPNAVLISPTHKNLTAEKQLDALSPQSNSTPSSPINSRQQRLSK KAGGPPHARSFDETMPSSASPLLGRRVNISSPITIHKKERMSRKTSGNSV SSQPSADDGEALPPSLAASTPTSQKKNSRKISVNVSEVHPQSNADASRCS SSSGQDSPTKSDRRRRVSVYFNKKGGGRRDSNVVGNGTRSLSASRYGPGE GGEATTSDRERTNSVSSRTSSATGGGRRKLSKSSNRALDVGDNKVPWCGC WGNGC--------------------------------------------- ---------I >Tce xx------------------------------------------------ -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ----------xxxxxxxANQ------------------------------ -------------------------------------------------- -------------------------------------------------- ----------------------------------VKEVIDALETQLGDTG LRGGVRGVRAQSGECYICLSRQQEAQSLLRSGLGLRGHHLTLLDVSRDSL VVCLSGVPHHVTDTAVALLAASFGTVI----------------------- -------------------xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx xxxxGxxxxxxxxxxxxxxxxxxxxxx----------------------- -----------EVERRLYKGVDTGERLLRVKPNPGVDQLPPAVSLAGSQV KLRVLPPEEIAALGHA---------------------------------- -------------------------------------------------- --------------------GDLPLTTSPEPPTSSTQYGDDQRACSSSSD NSLNGDSRFKSHLNVRLKQPDTASTPNILPNTASLAPSQPPFFSTLPSTR KGPQWPTMDAEHQQVPRNPFSADYQATLPSNARLSSSDSSALAGNANPFT YPAHPNFDSEYVLPSPGPNPSGGRIPHQTISGHVPPPVIAPGTPLTHRPT PAPSYLNPNAVLISPTHKNLTAEKQLDALSPQSNSTPSSPINSRQQRLSK KAGGPPHARSFDETMPSSASPLLGRRVNISSPITIHKKERMSRKTSGNSV SSQPSADDGEALPPSLAASTPTSQKKNSRKISVNVSEVHPQSNADASRCS SSSGQDSPTKSDRRRRVSVYFNKKGGGRRDSNVVGNGTRSLSTSRYGPGE GGEATTSDRERTNSVSSRTSSATGGGRRKLSKSSNRALDVGDNKVPWCGC WGNGC--------------------------------------------- ---------I >Tcm MxxxxxxxxxxxxxxRKDINVKPxxxxxxxxxxGMLYENEELRLxxxNIN AEVExGQSDIKKLxxxxxxxxxxxWGLRDEYDRLEGLLKKRRGQDSENEE EEYxxxxxEEDEDxEEEDADEEDxxxxxxxxxxxxxxxxxxxxxxxxxxx xxxxxxxxxxxxxxxxGLSVVDEEADETQTVSEQSPGYQQETDQDGGPYC GTITLPNGRQxVFFSDAMAAPRRKVNGAGPNISFSEYQALLASHNVDPGD MQFPPGDPPEGYTYPYYENTGAIGLGALDSTALPPPPDDSDYFHxIARAx xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx xxxxxxxxxxx------xxx------------------------------ -------------------------------------------------- -------------------------------------------------- ----------------------------------VKEVIDALETQLGDTG LRGSVRGVRAQSGECYICLSRQQEAQSLLRSGLGLRGHQLTLLDVSRDSL VVCLSGVPHHVTDTAVALLAASFGTVI----------------------- -------------------------------------------------- -------------------------------------------------- ----------GEVERRLYKGVDTGERLLRVKPNPGVDQLPPAVSLAGSKV KLRVLPPEEVAALGHA---------------------------------- -------------------------------------------------- --------------------GDLPLTTSPEPPTSSTQYGDDQRACSSSSD NSLNGDSRFKSHLNVRLKQPDTASTPNILPNTASLAPSQPPFFSTLPSTR KGPQWPTMDAEHQQVPRNPFSTDYQATLPSNARLSSSDSSALAGNVNPFT YPAHPNFDPEYVLPSPGLNPSGGRIPHQIISGQVPPPVIAPGTPLTHRPT PAPSYLNPNAVLISPTHKNLTAEKQLDALSPQSNSTPSSPINSRQQRLSK KAGGPPHTRSFDETMPSSASPLLGRRVNISSPITTHKKERMSRKTSGNSV SSQPNADDGEALSPSLAASTPTSQKKNSRKISVNVSEVHPQSNADASRCS SSSGQDSPTKSDRRRRVSVYFNKKGGGRRDSNVVGNGTRSLSASRYGPGE GGEATTSDRERTNSVSSRTSSATGGGRRKLSKSSNRALDVGDNKVPWCGC WGNGC--------------------------------------------- ---------I >Tte -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------ERRLYKGVDTGERLLRVKPNPGVDQLPPAVSLAGSKV KLRVLPPEEVAALGHA---------------------------------- -------------------------------------------------- --------------------GDLPLTTSPEPPTSSTQYGDDQRACSSSSD NSLNGDSRFKSHLNVRLKQPDTASTPNILPNTASLAPSQPPFFSTLPSTR KGPQWPTMDAEHQQVPRNPFSADYQATLPSNARLSSSDSSALAGNANPFT Y-------xEYVLPSPGPNPSGGRIPHQTISGHVPPPVIAPGTPLTHRLA PIPSYPNPNAALISPTHKNLTVEKQLDALSPQSNSTPSSPINSRQQRLSK KTGGPPHTRSFDETMPSSASPLLGRRVNISSPMTTHKKERMSRKTSGNSV SSQPNAEDEEAQPPSLAASTPTSQKKNSRKISVNVSEVHPQSNADASRCS SSSGQESPTKSDRRRRVSVYFNKKGGGRRDSNVMGNGTRSLSASRYVPGE GGEATTSDRERTNSVSSRTSSATGGGRRKLSKSSNRALDVGDNKVPWCGC WGNGC--------------------------------------------- ---------I >Tpa MxxxxxxxxxxxxxxRKDINVKPxxxxxxxxxxGMLYENEELRLxxxNIN AEVEKGQSDIKKLRRENEHLRREIWGLRDEYDRLEGLLKKRRGQDSENEE EEYDREDDEEDEDDEEEDADEEExxxxxxxxxxxxxxxxxxxxx-xxxxx xxxxxxxxxxxxVEFDGLSVVDEEADETQTVSEQSPGYQQETDQDGGPYC GTITLPNGRQGVFFSDAMAAPRRKVNGAGPNMSFPEYQALLASHNVDPGD MQCPPGDPPEGYTYPYYENTGAIGSGALVSTAPPPPPDDSDYFHSIARAG PDLFITGAYPVSKSPPEAMFPTGGNLDQLLRExxxxxxxxxxxxxxGDxx xxxxxxxxxxx------xxx------------------------------ -------------------------------------------------- -------------------------------------------------- ----------------------------------VKEVIDALETQLGDAG LRGGVRGVRAQSGECYICLSRQQEAQSLLRSGLGLRGHHLTLLDVSRDSL VVCLSGVPHHVTDTAVALLAASFGTVI----------------------- -------------------------------------------------- -------------------------------------------------- ----------GEVERRLYKGVDTGERLLRVKPNPGVDQLPPAVSLAGSKV KLRVLQPEEVAALGHA---------------------------------- -------------------------------------------------- --------------------GDLPLTTSPEPPTSSTQYGDDQRACSSSSD NSLNGDSRFKSHLNVRLKQPDTASTPNILPNTASLAPSQPPFFSTLPSTR KGPQWPTMDAEH-QVPRNPFSTDYQVTLPSNARLSSSDSSALAGNANPFT Y-------xEYVLPSPGPNPSGGRIPHQTISGHVPPPVIAPGTPLTHRLA PNPSYPNPNAALISPTHKNLTAEKQLDALSPQSNSTPSSPINSRQQRLSK KAGGPPHARSFDETMPSSASPLLGRRVNISSPMTTHKKERMSRKTSGNSV SSQPNAEDEEVQPPSLAASTPTSQKKNSRKISVNVSEVHPQSNADASRCS SSSGQESPTKSDRRRRVSVYFNKKGGGRRDSNVMGNGTRSLSASRYGPGE GGEATTSDRERTNSVSSRTSSATGGGRRKLSKSSNRALDVGDNKVPWCGC WGNGC--------------------------------------------- ---------I >Tsi -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ---xxxxxxxxxxTQSVVASLxxxxxxxxxxxxxxxxxxxxxxxxxxxxx xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxTVKEVIDALETQLGDTG LRGSVRGVRAQSGECYICLSRQQEAQSLLRSGLGLRGHQLTLLDVSRDSL VVCLSGVPHHVTDTAVALLAASFGTVI----------------------- -------------------------------------------------- -------------------------------------------------- ----------GEVERRLYKGVDTGERLLRVKPNPGVDQLPPAVSLAGSKV KLRVLPPEEVAALGHA---------------------------------- -------------------------------------------------- --------------------GDLPLTTSPEPPTSSTQYGDDQRACSSSSD NSLNGDSRFKSHLNVRLKQPDTASTPNILPNTASLAPSQPPFFSTLPSTR KGPQWPTMDAEHQQVPRNPFSTDYQATLPSNARLSSSDSSALAGNVNPFT YPAHPNFDPEYVLPSPGLNPSGGRIPHQIISGQVPPPVIAPGTPLTHRPT PAPSYLNPNAVLISPTHKNLTAEKQLDALSPQSNSTPSSPINSRQQRLSK KAGGPLHTRSFDETMPSSASPLLGRRVNISSPITTHKKERMSRKTSGNSV SSQPNADDGEALSPSLAASTPTSQKKNSRKISVNVSEVHPQSNADASRCS SSSGQDSPTKSDRRRRVSVYFNKKGGGRRDSNVVGNGTRSLSASRYGPGE GGEATTSDRERTNSVSSRTSSATGGGRRKLSKSSNRALDVGDNKVPWCGC WGNGC--------------------------------------------- ---------I >Tdi -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- --------xxxxxTQSVVASLxxxxxxxxxxxxxxxxxxxxxxxxxxxxx xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxTVKEVIDALETQLGDAG LRGSVRGVRAQSGECYICLSRQQEAQSLLRSGLGLRGHQLTLLDVSRDSL VVCLSGVPHHVTDTAVALLAASFGTVI----------------------- -------------------------------------------------- -------------------------------------------------- ----------GEVERRLYKGVDTGERLLRVKPNPGVDQLPPAVSLAGSKV KLRVLPPEEVAALGHA---------------------------------- -------------------------------------------------- --------------------GDLPLTTSPEPPTSSTQYGDDQRACSSSSD NSLNGDSRFKSHLNVRLKQPDTASTPNILPNTASLAPSQPPFFSTLPSTR KGPQWPTMDAEHQQVPRNPFSADYQATLPSNARLSSSDSSALAGNVNPFT YPAHPNFDPEYVLPSPGLNPSGGRIPHQIISGQVPPPVIAPGTPLTHRPT PAPSYLNPNAVLISPTHKNLTAEKQLDALSPQSNSTPSSPINSRQQRLSK KAGGPPHTRSFDETMPSSASPLLGRRVNISSPITTHKKERMSRKTSGNSV SSQPSADDGEALPPSLTASTPTSQKKNSRKISVNVSEVHPQSNADASRCS SSSGQESPTKSDRRRRVSVYFNKKGGGRRDSNVVGNGTRSLSASRYGPGE GGEATTSDRERTNSVSSRTSSATGGGRRKLSKSSNRALDVGDNKVPWCGC WGNGC--------------------------------------------- ---------I >Tbi M------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ------------xxxxxxxxxxxxxxxxxxx------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ----------SEVERRLYKGVDTGERLLRVKPNPGVDQLPPAVSLAGSKV KLRVLPPEEVAALGHA---------------------------------- -------------------------------------------------- --------------------GDLPLTTSPEPPTSSTKYGDDQRACSSSSD NSLNGDSRFKSHLNVRLKQPDTASTPNILPNTASLAPSQPPFFSTLPSTR KGPQWPTMDAEHQQVPRNPFSADYQATLPSNARLSSSDSSALA------- ---------------PGPNPSGGRIPHQTISGHVPPPVIAPGTPLTHRLA PIPSYPNPNAALISPTHKNLTVEKQLDALSPQSNSTPSSPINSRQQRLSK KTGGPPHTKSFDETMPSSASPLLGRRVNISSPMTTHKKERMSRKISGNSV SSQPNAEDEEAQPPSLAASTPTSQKKNSRKISVNVSEVHPQSNADASRCS SSSGQESPTKSDRRRRVSVYFNKKGGGRRDSNVMGNGTRSLSAS------ -------------------------------------------------- ---------------------------------------------xxxxx xxxxxxxx-- >Tps x------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ---------------------xxxxxxxxxxxxxxx-------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -----------------xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx xxxx---------------------------------------------- ----------GEVERRLYKGVDTGERLLRVKPNPGVDQLPPAVSLAGSKV KLRVLPPEEVAALGHA---------------------------------- ------xxxxxxxDTxxxxKFDxxxWNYALWQTGFKQDxxxxHxxxxxxx xxxxxxxxxxxxxxxxxxxxxxx--------------------------D NSLNGDSRFKSHLNVRLKQPDTASTPNILPNTASLAPSQPPFFSTLPSTR KGPQWPTMDAEHQQVPRNPFSADYQATLPSNARLSSSDSSALAGNVNPFT YPAHPNFDPEYVLPSPGLNPSGGRIPHQIISGQVPPPVIAPGTPLTHRPT PAPSYLNPNAVLISPTHKNLTAEKQLDALSPQSNSTPSSPINSRQQRLSK KAGGPPHTRSFDETMPSSASPLLGRRVNISSPITTHKKERMSRKTSGNSV SSQPSADDGEALPSSLNASTPTSQKKNSRKISVNVSEVHPQSNADASRCS SSSGQESPTKSDRRRRVSVYFNKKGGGRRDSNAVGNGTRSLSASRYGPGE GGEATTSDRERTNSVSSRTSSATGGGRRKLSKSSNRALDVGDNKVPWCGC WGNGC--------------------------------------------- ---------I