>Tge ---------MK--------------------------------------- -------------------------------------------------- -------------------------------------------------- ---------------------------KLEYSCGLGSVRPAWMQRFANTK CFMVVYSLLGTVQGMSYIYMxTxxxxxxKRxxxx---------------- -------------------------------------------------- --------------------SQTIGILMSGNEVSQVFLSLAMSYHGGRGN -------------------------------------------------- ----------------------------RPLWISWGVTFSAISCFILALP HLVYGPGKDAIALTEEFLDTTVLNSSIPKTNDRALLCSGNKTALAYCEED VSSGEHSLMPLILIFFSQFVLGIGTTLFHSLGQTYLDDHTKKTNAPLLL- -------------------------------------------------- -------------------------------------------------- --------------G----MVLSLRMLGPAAGFAFSSFCLSLYIDPTLTP VIKPTDPRWLGAWWLGWLVLGVLMLVFAFLISWFPRELPPKKKKLALNKV EKNKD--------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------xx----------------------- -----------xxx------xxxxxxxxxxxxx----------------- -------------------------------------------------- -------------------------------------------------- --------------------------------x-----xxxxxxxxxxxx xxxxLDVGNSCNMGCECDDLKYQPVCYREKDITFYSACHIG--------- -xxDTIHxKNGSTT------------------------------------ -------SFTNCTCLPxxxxxxxSSGLSSSLTTQHPLYAKDLSAVMTNGP CPVDCTRILYTYILVGFFIQALSSSGRIGNVLVNFRCVKQKDKVFAQGLS LLLVSxxxxxxxxxxxxxx------------------------------- ------------x------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ----------------xxxxxxxxxxxxx--------------------- -------------------------------------------------- --------------xxxxxxxxxxxxxxxxxxxxxxx------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ---------------------------------xx--------------- --------------------------x >Tpa ---------MK--------------------------------------- -------------------------------------------------- -------------------------------------------------- ---------------------------KLEYSCGLGSVRPSWMQRFANTK CFMVVYSLLGTVQGMSYIYMxTxLxxxxKRxxxx---------------- -------------------------------------------------- --------------------SQTIGILMSGNEVSQVFLSLAMSYHGGRGN -------------------------------------------------- ----------------------------RPLWISWGVTFSAISCFILALP HLVYGPGKDAIALTEEFLDTTVLNSSIPKTNDRALLCSGNKTALAYCEED VSSGEHSLMPLILIFFSQFVLGIGTTLFHSLGQTYLDDHTKKTNAPLLL- -------------------------------------------------- -------------------------------------------------- --------------Gxxxx------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- --------------------------- >Tce ---------MK--------------------------------------- -------------------------------------------------- -------------------------------------------------- ---------------------------KxxYSCGLGSVRPxxMQRFANxx CFMVVYSLxGTVxxxxxxYMSTTLxxxxKRxxxx---------------- -------------------------------------------------- --------------------SQxxGILMSGNEVSQVFLSLAMSYHGGRGN -------------------------------------------------- ----------------------------RPLWISWGVTFSAISCFILALP HLVYGPGKDAIALTEEFLDTTVLNSSIPKTNDRALLCSGNRTASAYCQED VSGGEHSLMPLILIFFSQFVLGIGTTLFHSLGQTYLDDHTKKTNAPLLL- -------------------------------------------------- -------------------------------------------------- --------------G----MVLSLRMLGPAAGFAFSSFCLSLYIDPTLTP VIKPTDPRWLGAWWLGWLVLGALMIVFAFLISWFPRELPPKKKKRSLNKI EKNKDTLIKTSNNTSNNKLSSESEPLNKGAVTESLNKIPIKIKKQEDDEx FMDSLKxLLQNKLLIYNIFAGVFYVxxxxxxxxxxxxxxxxQYHTSAAGA SMISGSASVFAMIFGFLGSGYFIGRFKPRPRLVLGW-------------- ------------------------------------------NVILGAVH xxxxxxxxYLGCxDKGVYGLDPVTGx------------------------ -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ----LDVGNSCNMGCDCDDLKYQPVCYREKDITFYSACHIG--------- -xxDTxxxxNGSTT------------------------------------ -------SFTNCTCLPxxxxxxxLSGLSSSLTTEHPLYAKDLSAVMTNGP CPVDCTRILYTYILVGFFIQALSSSGRIGNVLVNFRCVKQKDKVFAQGLS LLLVSxxxxxxxxxxxxxx------------------------------- ------------xxx----------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- xxxxxxxxxGExxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx xxxLYGDxxxxxxxxxRRSSAxxxxxx---------xxxxxSRQPSIADR SRQGSVSDRSRRPSFVDSxxxxSVQNSRQPSLGNTSxxxxATDSSSIxxx xxxxxxxxxxxxxxxQK--------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- --------------------------- >Tdi ---------MK--------------------------------------- -------------------------------------------------- -------------------------------------------------- ---------------------------KLEYSCGLGSVRPAWMQRFANTK CFMVVYSLLGTVQGMSYIYMxTxLxxxxKRxxxx---------------- -------------------------------------------------- --------------------SQTIGILMSGNEVSQVFLSLAMSYHGGRGN -------------------------------------------------- ----------------------------RPLWISWGVTFSAISCFILALP HLVYGPGKDAIALTEEFLDTTVLNSSIPKTNDRALLCSGNRTASAYCQED VSGGEHSLMPLILIFFSQFVLGIGTTLFHSLGQTYLDDHTKKTNAPLLL- -------------------------------------------------- -------------------------------------------------- --------------G----MVLSLRMLGPAAGFAFSSFCLSLYIDPTLTP VIKPTDPRWLGAWWLGWLVLGALMIVFAFLISWFPRELPPKKKKRSLNKI EKNKDTLIKTSNKTSNNKLSSESEPLNKGAVTESLNKIPIKIKKQEDDEx FMDSLKGLLQNKLLIYNIFAGVFYVMGEAGTMTFSMKYMEIQYHTSAAGA SMISGSASVFAMIFGFLGSGYFIGRFKPRPRLVLGW-------------- ------------------------------------------NVILGAVH xxxxxxxxYLGCQDKGVYGLDPVTGx------------------------ -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ----LDVGNSCNMGCECDDLKYQPVCYREKDITFYSACHIG--------- -xxDTIHxKNGSTT------------------------------------ -------SFTNCTCLPxxxxxxxLSGLSSSLATEHPLYAKDLSAVMTNGP CPVDCTRILYTYILVGFFIQALSSSGRIGNVLVNFR-------------- -------------------------------------------------- --------------xxxxxxxxxxxxxxxxxxxxxxxxxxxxTxxxxxxx xxxxxxxxxxxxxxxxx--------------------------------- -------------------------------------------------- -------------------------------------------------x xxxxxxxxCGExxxxxxxxKDKFRIYMNVTAAVLTSLGVILDIKVxxxxx TLxLYGDxxExxxxxxRRSSAYxxxxxxxxxxxRQPxxANRSRQPSIADR SRQGSVSDRSRRPSFVDSxxxxSVQNSRQPSLGNTSxKNSATDSSSIVDx xxNxxxxxxxxxxxxxx--------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- --------------------------- >Tte ---------MK--------------------------------------- -------------------------------------------------- -------------------------------------------------- ---------------------------KLEYSCGLGSVRPAWMQRFANTK CFMVVYSLLGTVQGMSYIYMxTxxxxxxKRxxxx---------------- -------------------------------------------------- --------------------SQTIGILMSGNEVSQVFLSLAMSYHGGRGN -------------------------------------------------- ----------------------------RPLWISWGVTFSAISCFILALP HLVYGPGKDAIALTEEFLDTTVLNSSIPKTNDRALLCSGNKTALAYCEED FSSGEHSLMPLILIFFSQFVLGIGTTLFHSLGQTYLDDHTKKTNAPLLL- -------------------------------------------------- -------------------------------------------------- --------------G----MVLSLRMLGPAAGFAFSSFCLSLYIDPTLTP VIKPTDPRWLGAWWLGWLVLGVLMLVFAFLISWFPGELPPKKKKRALNKV EKNKDRLIKTPNNTSNNKLSSESEPLNKGAITESLNKIPIKIKKQEDDE- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- --------------------------------xxxxxxxxxxxxxxxxxx xxxRLDVGNSCNMGCECDDLKYQPVCYREKDITFYSACHIG--------- -xxDTIHxKNGSTT------------------------------------ -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ----------------------------xxxxxxxxxxxxxxxxxxxxxx xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx xxxxxxxxxxxxxxx----------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- --------------------------- >Tms ---------MK--------------------------------------- -------------------------------------------------- -------------------------------------------------- ---------------------------KLEYSCGLGSVRPAWMQRFANTK CFMVVYSLLGTVQGMSYIYMxxxxxxxxKRxxxx---------------- -------------------------------------------------- --------------------SQTIGILMSGNEVSQVFLSLAMSYHGGRGN -------------------------------------------------- ----------------------------RPLWISWGVTFSAISCFILALP HLVYGPGKDAIALTEEFLDTTVLNSSIPKTNDRALLCSGNRTASAYCQED VSGGEHSLMPLILIFFSQFVLGIGTTLFHSLGQTYLDDHTKKTNAPLLL- -------------------------------------------------- -------------------------------------------------- --------------G----MVLSLRMLGPAAGFAFSSFCLSLYIDPTLTP VIKPTDPRWLGAWWLA---------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ----------------------xxxxxxxxxxxxxxxxxxxxxxxxxxxx xxxxxxxxxxxx-------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -xxxLDVGNSCNMGCDCDDLKYQPVCYREKDITFYSACHIG--------- -xxDTxHxKNGSTT------------------------------------ -------SFTNCTCLPxxxxxxxLSGLSSSLTTEHPLYAKDLSAVMTNGP CPVDCTRILYTYILVGFFIQALSSSGRIGNVLVNFRCVKQKDKVFAQGLS LLL----------------------------------------------- -------------------------------------------------- ----------------xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx--- --xxxxxxSLRxxxxxxRGxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx xxxxxxxxxxxxxx-----------------------xxxxxxxxxxxxx xxxxxxxxCGExxxxxxxxKDKFRIYMNVTAAVLTSLGVILDIKVxxxxx TLxLYGDxxxxxxxxxRRSSAYxxxxxxxxxxxRQPxxxxxSRQPSIADR SRQGSVSDRSRRPSFVDSxxxxSVQNSRQPSLGNTSxKNSATDSSSIVxx xxNxxxxxxxxxxxx----------------------------------- -------------------------------------------------- ------------------------------------xxLLISDEMTLTTT LEVALLLVIPHQYMGLPENTFTGxxVNTVDESNWRSNIDSLSPYKISETA RSGRFFNPFLKLGLINSFLAGSLLGSTIASGVGTLTANNVYNPYGGSLNS AFTWSFGNGGIYPPISVAPQLPVYPQGGIQRPGGLVYPQANPFLPQGPVL PQHTFLPQQPFLPAGTFLPSGPGTDLSDYQTLPSPLTRHLVNVGNAKKKN LRGPGTDLSDYQTLPSPLTRHxxNxGNARPPPWC---------------- --------------------------- >Tsi ---------MK--------------------------------------- -------------------------------------------------- -------------------------------------------------- ---------------------------KLEYSCGLGSVRPAWMQRFANTK CFMVVYSLLDST---------------------xxxxxxxxxxxxxxxxx xALGMAxxVVIADAPDDxxxxxxxxxxxxxxxxxxxxWLQGAHSPTREHN SLRLGGLDGEGPGxxxxxxxPQxxGILMSGNEVSQVFLSLAMSYHGGRGN -------------------------------------------------- ----------------------------RPLWISWGVTFSAISCFILALP HLVYGPGKDAIALTEEFLDTTVLNSSIPKTNDRALLCSGNRTASAYCQED VSGGEHSLMPLILIFFSQFVLGIGTTLFHSLGQTYLDDHTKKTNAPLLL- -------------------------------------------------- -------------------------------------------------- --------------G----MVLSLRMLGPAAGFAFSSFCLSLYIDPTLTP VIKPTDPRWLGA-----xxxxx---------------------------- -------------------------------------------------- -------------------------------------------------- -----------------------------------xxxxxxxxxxxxxxx xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx------- ----------------------xxxxxxxxxxxxxxxxxxxxxxxxxx-- -------------xxxxxxxx----------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------xxx---------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -----------xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx xxxxxxxxxxxxx------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ----------------xxx------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------xxxxxxxxxxxxxxxxxxx xxxxxxxxxxxxxxxxxxxxxxxxxxx >Tbi ---------M---------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ------------------YVxxxxxxxx---------------------- -------------------------------------------------- ------------------------GILMSGNEVSQVFLSLAMSYHGGRGN -------------------------------------------------- ----------------------------RPLWISWGVTFSAISCFILALP HLVYGPGKDAIALTEEFLDTTVLNSSIPKTNDRALLCSGNKTALAYCEED ISSGEHSLMPLILIFFSQFVLGIGTTLFHSLGQTYLDDHTKKTNAPLLL- -------------------------------------------------- -------------------------------------------------- --------------G----MVLSLRMLGPAAGFAFSSFCLSLYIDPTLTP VIKPTDPRWLGAWWLGWLVLGVLMLVFAFLISWFPRELPPKKKKRALNKV EKNKDRLIKTPNNTSNNKLSSESEPLNKGAVTESLNKIPIKIKKQEDDE- -------------------------------------------------- ----GSASVFAMIFGFLGSGYFIGRFKPRPRLVLGW-------------- ------------------------------------------NVILGAVH -------------DKGVYGLDQVTGx------------------------ ----------xxxx------xxxxxxxxxxxxx----------------- -------------------------------------------------- -------------------------------------------------- --------------------------------x-----xxxxxxxxxxxx xxxxxxxxxxxNMGCECDDLxxxPxxxREKxxxxxxxxxxxxxxxxxxxx xxxx----HxxxxxxxxxxxxxNLNLPVxxxxxxxxxxxxxHAVTKGGKK YNxxxxxSFTNCTCLPxxxxxxxxxxxxxxxxxxxxxxAxxLSAVxxxxx CxxxxxxxxYTYIxxxxxxxxxxxxxRIGNVxxxxxxxxxxxxxxAxxxx xxxxxxxxxxxxxxxxxxxxxxxxxx--------------------xxxx xxxxx------------------------------------------x-- -------------------------------------------xxxxxxx xxxxx------------------------xxxxxxxxxxxxxxxxxxxxx xxxxx--------xxxxxxxxxxxxxxxxxxxxxxxxxxxxxx------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ---------------------------------xxxxxxxxxxxxxxx-- --------------------------- >Tps xxxSSLSQDMKIKCHNEEVGIQLWFGFCSSSMDAEVxxxxxxx------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ------------------------xxxxxxxEVSQVFLxxxxxxxxxxxx xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx xxxxxxxxxxxxxxxxxxxxxxxxxxxxRPLWISWGVTFSAISCFILALP HLVYGPGKDAIALTEEFLDTTVLNSSIPKTNDRALLCSGNRTASAYCQED VSGGEHSLMPLILIFFSQFVLGIGTTLFHSLGQTYLDDHTKKTNAPLLLE Q---------------------------------------------HALS KKKLPYTIPPEPALREQQCSLFLAVTPFSPPPSxARMxxxxxxxxTxxLF NNNNDDAKLFx---G----MVLSLRMLGPAAGFAFSSFCLSLYIDPTLTP VIKPTDPRWLGAWWLGWLVLGALMIVFAFLISWFPRELPPKKKKRSLNKI EKNKDTLIKTSNKTSNNKLSSESEPLNKGAVTESLNKIPIKIKKQEDDE- ------xLLQNKLLIYNIFAGVFYVMGEAGTMTFSMKYMEIQYHTSAAGA SMISGSASVFAMIFGFLGSGYFIGRFKPRPRLVLGW-------------- ------------------------------------------NVILGAVH -------------DKGVYGLDPVTGx------------------------ ----------xxxx------xxxxxxxxxxxxx----------------- -------------------------------------------------- -------------------------------------------------- --------------------------------x-----xxxxxxxxxxxx xxx----------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- --------------------------- >Tcm ---------MKxKCHNEEVGIQLWFGFCSSSMDAKVxxxxxxxxxxxxxx YSARNVVHLYVxxINHIGKEIQDTxxxxxxxxxxxxxxxxxxxxxxxxxx xxxxxxxxxxxxxxxxxxxAxxxxxxxxxxxxxxxxxxxxxxxEVTCRRR RRGSLRRPLFGExxxxxxxxDRGTLxxx---------------------- -------------------------------------------------- -------------------------------------WLQGAHSPTREHD SLRLGGLDGEGPGxxxxxxxxxxxGILMSGNEVSQVFLSLAMSYHGGRGN -------------------------------------------------- ----------------------------RPLWISWGVTFSAISCFILALP HLVYGPGKDAIALTEEFLDTTVLNSSIPKTNDRALLCSGNRTASAYCQED VSGGEHSLMPLILIFFSQFVLGIGTTLFHSLGQTYLDDHTKKTNAPLLLE KVSPHLRRRRVEINFRKNPLSTTDHDYNLDLPVIGSIVYCENNALDHA-- -------------------------------------------------- ----------AKExG----MVLSLRMLGPAAGFAFSSFCLSLYIDPTLTP VIKPTDPRWLGAWWLGWLVLGALMIVFAFLISWFPRELPPKKKKRSLNKI EKNKDTLIKSSNKTSNNKLSSESEPLNKGAVTESLNKIPIKIKKQEDDE- -------------------------------------------------- ----GSASVFAMIFGFLGSGYFIGRFKPRPRLVLGW-------------- ------------------------------------------NVILGAVH -------------DKGVYGLDPVTGx------------------------ ----------xxxx------xxxxxxxxxxxxxxxxxxxxxxxxxxxxxx xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx----------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- 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