>Tge -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------QKSDERT KELLGFVQKSDERINDLLEFVQRSDERTNKLLEFVPKSDERIVKTSEFIN RYDTIAETWKSSANLASKAFNNPALFKYLENGRETCVKTLGQTHSTEINT SQENVKSVIGENSVPFQDNMTINKPNKDSNIVP--------------TNI Vxxxxx---------------RESGDQT-DPSK----NVTKARIVNNEQS KETGPLRANKTNVNEYFDKINKQVDSNEDLGEDESPKQSSWLERVSNLVL ALTPDENGSVTPLMELAESFEQSLNNLKKSIASGKPSELLEKMKISAKKA QETASNLIYEVNVV------------------------------------ -------------------------------------------------- -------------------------------------------------- ---------KNKTLSKMLTKLTKFKNKLHDKWCYLKRQDNDYHILNWLES KIFEDCNEESNKSYKGSNAQNLENKRSLSNKMDPSQDNLSVFLKNTMKSH NSYENKRHFKKYNELSAEDKRKNFKYSKNNNLPDSNTRKIYKDRPAGEKH FGSHKNSNSQKHSKGSDQRSDDRKHSKV---------------------- ----xxxxxxxxxxxxxxxxxxxxxxxxxxRxxYTKESCRKVEYSKEPNx IGKLSTQDKCSNENLKNGWTINDKGEKSCNISGEWVIKLSKGRETSRKNN ERSDWLFERAKARKVRRETDADQSEWYFDRARKREHCRQHPDTDWCLSAK YSDLGANKYDKYHEDDDDDDDDDVEYWKTTQWSYQ--------------- ---------------------- >Tbi -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------LEFVQKSDERTKELLEFVQKSDERT KELLEFVQKTDERINDLLESVQRSDERTHKLLEFVPKSDERIVKTSEFIN RYDTIAETWKSSANLASKAFNNPALFKYLENGRETYVKTLGQTHSTEINT SQENVKSVIGENSVPFQDTMTINKPNKDSNIVPxxxxxxxxxxxxxxxxx xxxxxx---------------RESGxxx-xPSK----NVTKAKIVNNEQS KETGPLKANKTNVNEYFDKINKQVDSNKDLGEDESPKQSSWLERVSNLVL ALTPDENGSVTPLMELAESFEQSLNNLKKSIASGKPSELLEKMKISAKKA QETATNLIHEVNVV------------------------------------ -------------------------------------------------- -------------------------------------------------- ---------KxxxxxxMxxxxxxFKxxxxxxxxxxxxxxxxxxxxxxxxS KIFEDCNEESNxxxxxxxxxxxxxKRSVSNxMDPSQDNxxxxxxxxxKSH NSYENKRHFKKYNELSxxDKRKNFKYSKNxNxPxxxxxxxxxDxPAGEKH FGSHKNPxxxxxxxxxxxxxxxxxxxxxx-------------xxxxxxxx xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx--xxxxxCRKVEYSKExxx IxKLSTQDKCSNENLKNGWTINDKGEKSCNISGEWVIKLSKGRETSRKNN ERSDWLFERAKARKVRRETDADQSEWYFDRARKREHCRQHPDTDWCLSAK YSDLGANKYDKYHE--DDDDEDDVEYWKTTQWSYQTPLRPLASAGKWFKN TFSEFKEKMNYYQNNQHKFNYx >Tms ------------------SVIEKQAELDGEPGKQVLVGINIENIEDIASN SSDGESLEVIEEDVTTHVEY---------------------------MSD EETDGFSVISDSDCPVDRTFSDEIEWAPWSPNKRKIYVHCCNPVLNSWLN FILIMVLATVAGLGLGHFIGSQENQFYPSELSKLQKMKSYNSPRDKVNLE LQAQTLEVDKLTQSDKSPLELL-DVLHKSEKEALESAQLSDTRTNELLEI MQKFSERTNHLLELVEQYDGRTNQLLEFVQKS--------------xxxx xxxLEFVQRSDERTNKxxxxxx--------------NSDERAVKTSEYIN RHDTIPETWKASANLASKAYNNPTLFKFLENGQETYVKTLGQTHSIEINT PQENVKSVIGESSVPFQETMTINKPNKDSKIVP--------------TNN V---------------xxxxxRESDDxxAxxxx----NVTKAQIVNNEQP KETGPLRANETNVNEYFDKINKQVESNENLSEDESPKQSSWLERVSNLIL ALTPNENGRVTPLMELAESFEQSLNNLKKAISSGEPSKLLEKMKISAKKA QETASNLIHDVNIV------------------------------------ -------------------------------------------------- -------------------------------------------------- ---------KNKTLSKMLTKLTKFKNKLHDKWCYLKRQDYNSHILNWLES KIFEDCNEESNKQYKGSKAQNFEKKRSVSNKMNFNQDNLSVSLKNTMKSH NNYENKKNSKKYNELSAEDKRKNFKHSKDNNSPDSNTRKIYKDKPAGEKH FGAHKNPNSQKYSKEFDQRSDDRKHSKEFDQRSxxxxxxxxxxxx----- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ---------------------- >Tsi MESDNTD-SSESGMSDSWSVIEKQAELGGEPRKQDRVERNIENIEDIASN SSDGESLEVIEEDITAHVEY---------------------------MSD EESDGFSVISDSDCPVDRTFSDEIEWAPWATNKRKIYVHCCNPVLNSWLN FILIMVLATVAGLGLGHFIGSQENQFYPNELSKLQKMKSYNSPRDKVNLE LQAQTLEVDKLTQSDKSPLELL-DVLHKSEKDALESAQMSDTRTNELLEI MRKFSERTNYLLELVEQYDGRTNELLEFVQKSDERTNDLLKSVQISDERT KELLEFVQRSDERTNKLLEFVQKSEERTKELLEFVHKSDERGVKTSEFID RYDTIAETWK-STNLASKALNNPTLFKFLENGQETYVKTLGQTHSIKINT PQENVKSAIGENSVPFQETMTINRPNKDSKIVP--------------ANN V---------------xxxxxRESDDxxAxxxxxxxxNVTKAQIINNEQP NETGPLRANETNANEYLDKINKQVESNENLSEDESPKQSSWLESVSNLVL ALTPNENCRVTPLMELAESFEQSLNNLKKSIASGEPSKLLEKMKISAKKA QETASNLIHDVNMV------------------------------------ -------------------------------------------------- -------------------------------------------------- ---------KNKTLSKMLTKLTKFKNKLHDKWCYLKRQDNNYHILNWLES KIFEDCNEESNKHYKGGKAQNLENKRSLSNKMNPNQDSLSVSLKNTMKSH NNYENKKDLKKYNELSSEDKRKIFKHSKNHYSPDSNTRKINKDRPAGEKH FGDHKNPNSQKYLKEFDQRSDDGKHSKESDQRSxxxxxxxxxxxx----- -----------------xxxx-----------xxxxxx------------ -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ---------------------x >Tcm MESDNTD-SSESGMSDSWSVIEKQAELGGEPGKQDLVERNIENIEDIASN SSDGESLEVIEEDITAHVEY---------------------------MSD EETDGFSVISDSDCPVDRTFSDEIEWAPWARNKRKIYVHCCNPVLNSWLN FILIMVLATVAGLGLGHFIGSQENQFYPNELSKLQKMKSYNSPRDKVNLE LQAQTLEVDKLTQSDKSPLELL-DVLHKSEKDALESAQMSDTRTNELLEI MRKFSERTNYLLELVEQYDGRTNELLEFVQKSDERTNDLLKYVQISDERT KELLEFVQRSDERTNKLLEFVQKSEERTEELLEFVHKSDERGVKTLEFID RYDTIAETWK-STNLASKALNNPTLFKFLENGQETYVKTLGQTHSIKINT PQENVKSAIGENSVPFQETMTINRPNKDSKIVP--------------ANN V---------------xxxxxRESDDxxAxxxxxxxxNVTKAQIVNNEQP NETGPLRANETNANEYLDKINKQVESNENLSEDESPKQSSWLESVSNLVL ALTPNENCRVTPLMELAESFEQSLNNLKKSIASGEPSKLLEKMKISAKKA QETASNLIHDVNMV------------------------------------ -------------------------------------------------- -------------------------------------------------- ---------KNKTLSKMLTKLTKFKNKLHDKWCYLKRQDNNYHILNWLES KIFEDCNEESNKHYKGGKAQNLENKRSVSNKMNPNQDSLSVSLKNTMKSH NNYENKKDLKKYNELSSEDKRKIFKHSKNHYSPDSNTRKINKDRPAGEKH FGGHKNPNSQKYLKEFDQRSDDGKHSKESDQRSxxxxxxxxxxxxxxxxx xxxxxxxxxxxxxxxxxx-------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ---------------------- >Tdi MESDNTD-SSESGMSDSWSVIETQAELDGEPGKQDLVERNIENIEDIASN SSDGESLEVIEEDIMAHVEY---------------------------MSD EETDGFSVISDSDSPVDRTFSDEIEWAPWATNKRKIYVHCCNPVLNSWLN FILIMVLATVAGLGLGHFIGSQENQFYPNELSKLQKMKSYNSPRDKVNLE LQAQTLEVDKLTQSDKSPLELLxDVLHKSEKDALESAQMSDTRTNELLEI MQKFSERTNYLLELVEQYDGRTNELLEFVQKSDERTNDLLKSVQIPDERT KELLEFVQRSDERTNKLLEFVQKSEERTEELLELVHKSDERAVKTSEFIN RYDTIAETWKASANLASKALNNPTLFKFLENGQETYVKTLGQTHSIEINT PQENVKSAIGENSVPFQETMTINKPNKDSKIVP--------------ANN V---------------xxxxxRESDDxxAxxxxxxxxNVTKAQIVNNEQP KETGPFRANETNANEYLDEINKQVESNENLSEDESPKQSSWLERVSNLVL ALTPNENCRVTPLMELAESFEQSLNNLKKSIASGEPSKLLEKMKISAKKA QETASNLIHDVNMV------------------------------------ -------------------------------------------------- -------------------------------------------------- ---------KNKTLSKMLTKLTKFKNKLHDKWCYLKGQDNNYHILNWLES KIFEDCDEESNKHYKGSKSQNLENKRSVSNKMNPNQDNLNVSLKNTMKSH NNYEKKKNLKKYNELSSEDKRKIFKHSKNHYSPDSNTRKIYKDRPAGEKH FGGHKNPNSQKYSKEFGQRSDDGKHSKESDPRN-------------xxxx x------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ---------------------- >Tps MESDNTD-SSESGMSDSWSVIETQAELDGEPGKQDLVERDIENIEDIASN SSDGESLEVIEEDITAHxxx---------------------------MSD EETDGFSVISDSDCPVDRTFSDEIEWAPWATNKRKIYVHCCNPVLNSWLN FILIMVLATVAGLGLGHFIGSQENQFYPNELSKLQKMKSYNSPRDKVKLE LQAQTLEVDKLTQSDKSPLELL-DVLHKSEKDALESAQMSDTRTNELLDI MQKFSERTNYLLELVEQYDGRTKELLEFVQKPDERTNDLLKSVQRSDERT KELLEFVQRSDERTNKLLEFVQKSEERREELLEFVHKSDERAVKTSEFIN RYDTIAETWKASANLASKALNNPTLFKFLENGRETYVKTLGQTHSIEINT PQENVKSVIGENSVPFQETMTINKPNKDSKIVP--------------ANN V---------------xxxxxRESDDxxADPSKxxxxNVTKAQIVDNEQP KETGPLRANETNANEYIDKINKQVESNENLSEDESPKQSSWLERVSNLVL ALTPNENCRVTPLMELAESFEQSLNNLKKSIASGEPSKLLEKMKISAKKA QETASNLIHDVNMIxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx xxxxxxxxxxxx-------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- --------x----------------------------------------- -------------------------------------------------- ---------------------x >Tte MEFDNTDxSSESGMSDSWSVIEKQAELDDEPVKQYLVERNTEDIEDIASN SSDGESLEVVEEDITAHVEY---------------------------MSD EETDGFSVISDSDCPVD----DEI---xWALNKRRIYVHCRNPVLNSWLN FILITVLATVIGLGLGHFIGSQENQFYPSELSKLQKTNSYNSPRD--NLE LEAQTLEVDKLTQSDKNPLELL-DVLHKSEREALEFAQMSDTRTNELLDI MQTFNERTNYLLEHVEQYDGRTNELLEFVQKSDERTKELLEFVQKSDERT KELLEFVQKTDERINDLLESVQRSDERTHKLLEFVPKSDERIVKTSEFIN RYDTIAETWKSNANLASKAFNNPALFKYLENGRETYVKTLGQTHSTEINT SQENVKSVIGENSVPFQDTMTINKPNKDSNIVP--------------TNN Vxxxxxxxxxxxxxxxx--------------------NVTKAKIVNNEQS KETGPLKANKTNVNEYFDKINKQVDSNKDLGEDESPKQSSWLERVSNLVL ALTPDENGSVTPLMELAESFEQSLNNLKKSIASGKPSELLEKMKISAKKA QETASNLIHEVNVIxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx xxxxxxxxxxxx---------------------xxxxxxxxxxxxxxxxx xxxxxxxxxxxxxxxxxxxxxxxxxxxx---------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ---------------------- >Tpa -------------------------------------------------- -----------------------------------------------MSD EETDGFSVISDSDCPVD----DEI---xWTPNKRRIYVHCRNPVLNSWLN FILIMVLATAAGLGLGHFIGSQENQFYPSELSKLQKMNSYNSPRD--NLE LEAQTLEVDKLTQSDKNPLELL-NVLHKSEREALELAQMSDTRTNELLDI MQTFSERTNYLLEHVEQYDGRTNELLEFVQKSDERTKELLEFVxxxxxxx xxxxxxxxxxxxxxxxxxxxxxx--------------SDERTIKTSEFIN RYDTIAATLKSSANLASKALNNPALFKYLENGQETYVKTLGQTHSTEINT PQENVKSVIDEKSVPFQDTMTINKPDKDSNIVP--------------TNN Vxxxxxxxxxxxxxxxx--------------------NVTKAKIVNNEQS KETGPLRVNKTNVNEYFDKINKQVDSNKDLGEDESPKQSSWLERVSNLVL ALTPDENGSVTPLMELAESFEQSLNNLKKSIASGKPSELLEKMKISAKKA QETASNLIHEVNMIxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx xxxxxxxxx----------------------------------------- -------------------------------------------------- ----------xx-------------------------------------- -------------------------------------------------- -------------------------------------------------- ------------------xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxTKESxxxxxxxxx--- -------------------------------------------------- -----xxxx----------------------------------------- -------------------------------------------------- ---------------------x >Tce MESDNTD-SSESGMSDSWSVIEKQAELDGEPGKQVLLGRNIENIEDIASN SSDGESLEVIEEDCST--xxMKISQVPTLTLTGQRRGRSPYSLxxxxMSD EETDGFSVISDSDCPVDRTFSDEIEWAPWSPNKRKIYVHCCNPVLNSWLN FILIMVLATVAGLGLGHFIGSQENQFYPSELSKLQKMKSYNSPRDKVNLE LQAQTLEVDKLTQSDKSPLELL-DVLHKSEKEALESAQL----------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ----------------------xSDDxxAxxxx----NVTKAQIVDNEQP --TGPLRANETNVNEYFDKINKQVESNENLSEDESPKQSSWLERVSNLVL ALTPNENCRVTPLMELAESFEQSLNNLKKAISSGEPSKLLEKMKISAKKA QETASNLIHDVNIV------------------------------------ -------------------------------------------------- -------------------------------------------------- ---------KNKTLSKx--------------------------------- -------------------------------------------------- ----------------AEDKRKNFKHSKDNNSPDSNTRKIYKDRPAGEKH FGAHKNPNSQKYSKDFDQRNDDRKHSKEFDQRSxxxxxxxxxxxxxxxxx xxxxxxxxxxxxxxxxxSxQRNDDTNYIRDR--YTKESCHEGEYNKEPNx IGKLSTQDKCSNEKLENGWTINDKGEKSCNISGEWVIKLSKGRETSRKNN ERSDWLFERAKARKARRETDADQS-------------------------- -------------------------------------------------- ---------------------E