>Tge -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- --------------------------------xxxxxxxxxxxxxxxxxx xxSATLSGGPEIYGRSGLNYLFSGTENMVEEVLGEDLDDSAPSDWQLFDK VRSQDIRLLKTLNVGTIVDFMVEKKKVKFGMNVTSSEKVDKENRYSEFTI ISLPYPGCEFFKEYRDNDYIAQGLVFNWAQAHVDANIGIPDDPISSQLRI DWANYKMWDLVKLTQNYMKLLLRYLQENSTGLLIHCISGWDRTPLFVSLL RLSLWADGAIHQSLNAFQILYFTIAYDWLLFGHNLEDRLSKGEEIFFFCF YFLKHLVGDEYSVTPRKNKHPVIRNDSDLHLDGLLLDGEGPISSRGSNIS LNSSCSSVSSKSQDNPPLVFHTVPDTLEEQANGNLVSWPLHLQSTMLETS LYSTFGSRSQHTSRTSPVAVPATSRLKQRNDSNSSLNVGSWQLISGTGSL RGSASTSTSTSTFDSATPSSAASQNGSHI--------------------- -------------------------------------------------- -------------------------------------------------- ---------------------xxKMVYQYxxxxxxxxxxxxxxxxxxxxx xxxxxxxxxxRHPNPRTFxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx xxxxxxxxxxxxxx >Tte -----------xxxxxxPTxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx------------------- -------------------------------------------------- -----------------------------------------------xxx xxxVxSILYWMDxNxxLATxxxxxLKSRLFKSAYPTYS------------ ----------------------------------DMADIKSHHIQELLEY FSKNLYRAKETDQNxLLWEWWLSGTRYLGLCIELLELSSDGSLKHRCLHD LALPIAKRACTFWAMHDIT------------------------------- -------------------------------------------------- -------------------------------------------------- ---------------------------xGQDVMQHCLSLVSLDYSHIVIN NSSGELSAHYPSQLIILEYERPCNGINGCIKGAGDGPRTTSTIYESMHDV LKLRELFGKARFARCRARFPLPVILYKGKNICR----------------- --SATLSGGPEIYGRSGLNYLFSGTENMVEEVLGEDLDDSAPSDWQLFDK VRSQDIRLLKTLNVGTIVDFMVEKKKVKFGMNVTSSEKVDKENRYSEFTI ISLPYPGCEFFKEYRDNDYIAQGLVFNWAQAHVDANIGIPDDPISSQLRI DWANYKMWDLVKLTQNYMKLLLRYLQENSTGLLIHCISGWDRTPLFVSLL RLSLWADGAIHQSLNAFQILYFTIAYDWLLFGHNLEDRLSKGEEIFFFCF YFLKHLVGDEYSVTPRKNKHPVIRNDSDLHLDGLLLDGEGPISSRGSNIS LNSSCSSVSSKSQDNPPLVFHTVPDTLEEQANGNLVSWPLHLQSTMLETS LYSTFGSRSQHTSRTSPVAVPATSRLKQRNDSNSSLNVGSWQLISGTGSL RGSASTSTSTSTFDSATPSSAASQNGSRI--------------------- -------------------------------------------------- -------------------------------------------------- ---------------------xxxxxxxxxxxxxxxxxxxxxxxxxxxxx xxxxxxxxxxRHPNPRTFxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx xxxxxxxxxxxxxx >Tpa -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ------MWDLVKLTQNYMKLLLRYLQENSTGLLIHCISGWDRTPLFVSLL RLSLWADGAIHQSLNAFQILYFTIAYDWLLFGHNLEDRLSKGEEIFFFCF YFLKHLVGDEYSVTPRKNKHPVIRNDSDLHLDGLLLDGEGPISSRGSNIS LNSSCSSVSSKSQDNPPLVFHTVPDTLEEQANGNLVSWPLHLQSTMLETS LYSTFGSRSQHTSRTSPVAVPATSRLKQRNDSNSSLNVGSWQLISGTGSL RGSASTSTSTSTFDSATPSSAASQNGSRI--------------------- -------------------------------------------------- -------------------------------------------------- ---------------------xxKIVYQYxxxxxxxxxxxxxxxxxxxxx xxxxxxxxxxRHPNPRTFxxxx---------------------------- ------------xx >Tms -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -----------------------------------MADIKSHQIQELLEY FSKNLYRAKETDQN-------------------LLELSSDGALKHRCLHD LARSIAKRTCTFWDMHGITRVLSYVCLGA--------------------- --RPGLCSSAVIIARWIVQNRMEKCEGxx--------------------- -------------------------------------------------- ----------------------------GQDIMQHCLSLVSLDYSHIVIN NSSGELSAHYPSQLIILEYERPCNGINGCIKGAGDGPRTTSTIYESMHDV LKLRELFGKARFARCRARFPLPVILYKGKNICR----------------- --SATLSGGPEIYGRSGLNYLFSGTENMVEEVLGEDLDDSAPSDWQLFDK VRSQDIRLLKTLNVGTIVDFMVEKKKVKFGMNVTSSEKVDKENRYSEFTI ISLPYPGCEFFKEYRDNDYIAQGLVFNWAQAHVDANIGIPDDPISSQLRI DWANYKMWDLVKLTQNYMKLLLRYLQENSTGLLIHCISGWDRTPLFVSLL RLSLWADGAIHQSLNAFQILYFTIAYDWLLFGHNLEDRLSKGEEIFFFCF YFLKHLVGDEYSVTPRKNKHPVIRNDSDLHLDGLLLDGDGPISSRGSNIS LNSSCSSVSSKSQDNPPLVFHTVPDTLEEQANGNLVSWPLHLQSTMLETS LYSTFGSRSQHTSRTSPVAVPATSRLKQRNDSNSSLNVGSWQLISGTGSL RGSASTSTSTSTFDSATPSSAVSQNGSRIxxxxxxxxxxxxxxVxxxDGC FIHNSTxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxQDSGLGSLLG NFAE---------------------------------------------- -----------KVGIISTQRTxx--------------------------- -------------------------------------------------- -------------- >Tsi xxxxxxxxxxxx-------------------------------------- ------------------------------xxxxxxxxxxxxxxxxxxxx xxxxxxxxxxxxxxxxxx-------------------------------- -------------------------------------------------- -------------------------------------xxxxxxxxxxxxx xxxxDxxxxMRxxINxxxxxxxxxxxxxSxxxxxDMADIKSHQIQELLEY FSKNLYRAKETDQN-------------------LLELSSYSALKHRCLHD LARSIAKRACTFWDMHDITRVLSYICLGA--------------------- --RPGLSSSAVTIARWIVRSGMEKCEExxVQNKSKIIPSELRKYVTKLQL AHQSAICGQTSNLIGIEKVELEEVNPHLRGGRVENHLGKTTLSSPDRDSN LDLPVLSSRAPHDKRISQLRHRGGYHDxGQDIMQHCLSLVSLDYSHIVIN NSSGELSAHYPSQLIILEYERPCNGINGCIKGAGDGPRTTSTIYESMHDV LKLRELFGKARFARCRARFPLPVILYKGKNICR----------------- --SATLSGGPEIYGRSGLNYLFSGTENMVEEVLGEDLDDSAPSDWQLFDK VRSQDIRLLKTLNVGTIVDFMVEKKKVKFGMNVTSSEKVDKENRYSEFTI ISLPYPGCEFFKEYRDNDYIAQGLVFNWAQAHVDANIGIPDDPISSQLRI DWANYKMWDLVKLTQNYMKLLLRYLQENSTGLLIHCISGWDRTPLFVSLL RLSLWADGAIHQSLNAFQILYFTIAYDWLLFGHNLEDRLSKGEEIFFFCF YFLKHLVGDEYSVTPRKNKHPVIRNDSDLHLDGLLLDGDGPISSRGSNIS LNSSCSSVSSKSQDNPPLVFHTVPDTLEEQANGNLVSWPLHLQSTMLETS LYSTFGSRSQHTSRTSPVAVPATSRLKQRNDSNSSLNVGSWQLISGTGSL RGSASTSTSTSTFDSATPSSAVSQNGSRIxxxxxxxxxxxxxxVxxxDGC FIHNSTxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxQDSGLSSLLG NFAE---------------------------------------------- -----------KVGIISTQRTxx--------------------------- -------------------------------------------------- -------------- >Tcm -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ---------xxxxxxxxxxxxxxxxxxxxxxxxx---------------- ---------------------------------LLELSSYSALKHRCLHD LARSIAKRACTFWDMHDITRVLSYICLGA--------------------- --RPGLSSSAVTIARWIVRSGMEKCEEVRVQNKSKIIPSELRKYVTKLQL AHQSAICGQTSNLIGIEKVELEEVNPHLRGGRVENHLGKTTLSSPDRDSN LDLPVLSSRAPHDKR-------------GQDIMQHCLSLVSLDYSHIVIN NSSGELSAHYPSQLIILEYERPCNGINGCIKGAGDGPRTTSTIYESMHDV LKLRELFGKARFARCRARFPLPVILYKGKNICR----------------- --SATLSGGPEIYGRSGLNYLFSGTENMVEEVLGEDLDDSAPSDWQLFDK VRSQDIRLLKTLNVGTIVDFMVEKKKVKFGMNVTSSEKVDKENRYSEFTI ISLPYPGCEFFKEYRDNDYIAQGLVFNWAQAHVDANIGIPDDPISSQLRI DWANYKMWDLVKLTQNYMKLLLRYLQENSTGLLIHCISGWDRTPLFVSLL RLSLWADGAIHQSLNAFQILYFTIAYDWLLFGHNLEDRLSKGEEIFFFCF YFLKHLVGDEYSVTPRKNKHPVIRNDSDLHLDGLLLDGDGPISSRGSNIS LNSSCSSVSSKSQDNPPLVFHTVPDTLEEQANGNLVSWPLHLQSTMLETS LYSTFGSRSQHTSRTSPVAVPATSRLKQRNDSNSSLNVGSWQLISGTGSL RGSASTSTSTSTFDSATPSSAVSQNGSRIxxxxxxxxxxxxxxxxxxxxx xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx xxxx---------------------------------------------- -----------xxxxxxxxxxxx--------------------------- -------------------------------------------------- -------------- >Tdi -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -----------------------------------MADIKSHQIQELLEY FSKNLYRAKETDQN-------------------LLELSSYSALKHRCLHD LARSIVKRACTFWDMHDITRVLSYICLGAxxxxxxxxxxxxxxxxxxxxx xxx----------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- --------------------------------R----------------- --SATLSGGPEIYGRSGLNYLFSGTENMVEEVLGEDLDDSAPSDWQLFDK VRSQDIRLLKTLNVGTIVDFMVEKKKVKFGMNVTSSEKVDKENRYSEFTI ISLPYPGCEFFKEYRDNDYIAQGLVFNWAQAHVDANIGIPDDPISSQLRI DWANYKMWDLVKLTQNYMKLLLRYLQENSTGLLIHCISGWDRTPLFVSLL RLSLWADGAIHQSLNAFQILYFTIAYDWLLFGHNLEDRLSKGEEIFFFCF YFLKHLVGDEYSVTPRKNKHPVIRNDSDLHLDGLLLDGDGPISSRGSNIS LNSSCSSVSSKSQDNPPLVFHTVPDTLEEQANGNLVSWPLHLQSTMLETS LYSTFGSRSQHTSRTSPVAVPATSRLKQRNDSNSSLNVGSWQLISGTGSL RGSASTSTSTSTFDSATPSSAVSQNGSRI--------------------- -------------------------------------------------- -------------------------------------------------- ---------------------xx--------------------------- -------------------------------------------------- -------------- >Tps -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -----------------------------------MADIKSHQIQELLEY FSKNLYRAKETDQN-------------------LLELSSYSALKHRCLHD LARSIVKRACTFWDMHDITRVLSYICLGAxxxxxxxxxxxxxxxxxxxxx x------------------------------------------------- -------------------------------------------------- ----------------------------GQDIMQHCLSLVSLDYSHIVIN NSSGELSAHYPSQLIILEYERPCNGINGCIKGAGDGPRTTSTIYESMHDV LKLRELFGKARFARCRARFPLPVILYKGKNICR----------------- --SATLSGGPEIYGRSGLNYLFSGTENMVEEVLGEDLDDSAPSDWQLFDK VRSQDIRLLKTLNVGTIVDFMVEKKKVKFGMNVTSSEKVDKENRYSEFTI ISLPYPGCEFFKEYRDNDYIAQGLVFNWAQAHVDANIGIPDDPISSQLRI DWANYKMWDLVKLTQNYMKLLLRYLQENSTGLLIHCISGWDRTPLFVSLL RLSLWADGAIHQSLNAFQILYFTIAYDWLLFGHNLEDRLSKGEEIFFFCF YFLKHLVGDEYSVTPRKNKHPVIRNDSDLHLDGLLLDGDGPISSRGSNIS LNSSCSSVSSKSQDNPPLVFHTVPDTLEEQANG----------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------- >Tbi -------------------------------------------------- -------------------------------------------------- -----------------xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxFxQPPKRVLTQLFL LGAVISILYxMDxxxxxxxxxxxxxxxxxxKSAYPTYS------------ ----------------------------------DMADIKSHHIQELLEY FSKNLYRAKETDQNxLLWEWWLSGTRYLGLCIELLELSSDGSLKHRCLHD LALPIAKRACTFWAMHDIT------------------------------- -------------------------------------------------- -------------------------------------------------- ----------------------------------------------xVIN NSSGELSAHYPSQLIILEYERPCNGINGCIKGAGDGPRTTSTIYESMHDV LKLRELFGKARFARCRARFPLPVILYKGKNICR----------------- --SATLSGGPEIYGRSGLNYLFSGTENMVEEVLGEDLDDSAPSDWQLFDK VRSQDIRLLKTLNVGTIVDFMVEKKKVKFGMNVTSSEKVDKENRYSEFTI ISLPYPGCEFFKEYRDNDYIAQGLVFNWAQAHVDANIGIPDDPISSQLRI DWANYKMWDLVKLTQNYMKLLLRYLQENSTGLLIHCISGWDRTPLFVSLL RLSLWADGAIHQSLNAFQILYFTIAYDWLLFGHNLEDRLSKGEEIFFFCF YFLKHLVGDEYSVTPRKNKHPVIRNDSDLHLDGLLLDGEGPISSRGSNIS LNSSCSSVSSKSQDNPPLVFHTVPDTLEEQANGNLVSWPLHLQSTMLETS LYSTFGSRSQHTSRTSPVAVPATSRLKQRNDSNSSLNxGSWQLISGTGSL RGSASTSTSTSTFDSATPSSAASQNGSRI--------------------- -------------------------------------------------- -------------------------------------------------- ---------------------xx--------------------------- -------------------------------------------------- -------------- >Tce -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -----------------------------------MADIKSHQIQELLEY FSKNLYRAKETDQN-------------------LLDLSSDGALKHRCLHD LAWSIAKRACTFWDMHGITxVLSYVCLGA--------------------- --RPGLCSSAVTISRWIVQNRMVKCEGxx--------------------- -------------------------------------------------- -----------------------------------------------VIN NSSGELSAHYPSQLIILEYERPCNGINGCIKGAGDGPRTTSTIYESMHDV LKLRELFGKARFARCRARFPLPVILYKGKNICR----------------- --SATLSGGPEIYGRSGLNYLFSGTENMVEEVLGEDLDDSAPSDWQLFDK VRSQDIRLLKTLNVGTIVDFMVEKKKVKFGMNVTSSEKVDKENRYSEFTI ISLPYPGCEFFKEYRDNDYIAQGLVFNWAQAHVDANIGIPDDPISSQLRI DWGNYKMWDLVKLTQNYMKLLLRYLQENSTGLLIHCISGWDRTPLFVSLL RLSLWADGAIHQSLNAFQILYFTIAYDWLLFGHNLEDRLSKGEEIFFFCF YFLKHLVGDEYSVTPRKNKHPVIRNDSDLHLDGLLLDGDGPISSRGSNIS LNSSCSSVSSKSQDNPPLVFHTV--------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ---xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx xxxxxxxxxxxxx------------------------------------- -------------------------------------------------- --------------