>Tge -------------------------------------------------- -------------------------MxxRKGSSELLNSEVPRSKHA-SSD SLASDSKSSSLNSKLGQE-------------------------------- ------------SVSSGKASPPKSYTSAxSTSTENxxSALxxKVKGKI-- -------------------------------------------------- -------------------------------------------------- --------------xxxxx------------------------------- -------------------------------------------------- ----------------xxxxxxxxxxxxxxxxxxxDSSxxxxxxxxxATS xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxRNAVGKHNH xxxxxxxxxxxxxxxxxxxx-------------xxxxxxxxxxxxxxxx- -----xxTPCSQANVSEPGPPSRPDDPPLLPGEKVQGVAREVTYLCPYSG PARGVLSVTNYKLHFRSMDRDTPYVVDVPLGVVSRIEKVGGASSRGENSY GIEVFCKDMRNLRFAHKQENHSRRNVFEKLQQYAFPLSHKLPLFAFEYTE SFSENGWTVHEPMAELKRMGVPNDMWKISKLNEDYEVCDTYPMVWAVPAQ ASDDDLRAVAAFRSRGRIPVLSWIHPESQATITRCSQPLVGVSGKRCRED ERYIQLIMDANAQSHKLFIMDARPSANAIANKAKGGGYESEDAYQNAELV FLDIHNIHVMRESLRKLKELCFPNIEETRWLSGVESTYWLKHIKCILAAA VRIVDKVENHKTSVLVHCSDGWDRTAQMTALPMLMLDPYYRTIKGFEVLI EKEWLSYGHKFQHRIGHGDEHHSDADRSPVFLQFIDCVWQITTQFPNAFE FNDYFLITILDHLYSCRFGTFLCNS------------------------- --------------------------------------------DRERAL EGVKQQTVSLWSYINTNMDEYRNPLYWSGIGQQHVLVPVASMRHITLWKG HYCRWNPSMRPQ-------------------------------------- -------------------------------------------------- ------DPVFQRARELLVLKEQLERQVEECRREQQVRAARNMATPPRLAS PIHS---- >Tms -------------------------------------------------- -------------------------MxxRKGSSELLNSEVPRSKHA-SSD SLASDSKSSSLNSKLGQE-------------------------------- ------------SVSSGKASPPKSYTSAxSTSTENxxSALxxKVKGK--- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ------------ANVSEPGPPSRPDDPPLLPGEKVQGVAREVTYLCPYSG PARGVLSVTNYKLHFRSMDRDTPYVVDVPLGVVSRIEKVGGASSRGENSY GIEVFCKDMRNLRFAHKQENHSRRNVFEKLQQYAFPLSHKLPLFAFEYTE SFSENGWTVHEPMAELKRMGVPNDMWKISKLNEDYEVCDTYPTVWAVPAQ ASDDDLRAVAAFRSRGRIPVLSWIHPESQATITRCSQPLVGVSGKRCRED ERYIQLIMDANAQSHKLFIMDARPSANAIANKAKGGGYESEDAYQNAELV FLDIHNIHVMRESLRKLKELCFPNIEETRWLSGVESTYWLKHIKCILAAA VRIVDKVENHKTSVLVHCSDGWDRTAQMTALPMLMLDPYYRTIKGFEVLI EKEWLSYGHKFQHRIGHGDEHHSDADRSPVFLQFIDCVWQITTQFPNAFE FNDYFLITILDHLYSCRFGTFLCNS------------------------- --------------------------------------------DRERVL EGVKQQTVSLWSYINTNMDEYRNPLYWSGIGQQHVLVPVASMRHITLWKG HYCRWNPSMRPQ-------------------------------------- -------------------------------------------------- ------DPVFQRARELLVLKEQLERQVEECRREQQARAARNMATPPRLAS PIHS---- >Tsi -------------------------------------------------- -------------------------MxxRKGSSELLNSEVPRSKHAxSSD SLASDSKSSSLNSKLGQE-------------------------------- ------------SVSSGKASPPKSYTSAxSTSTENxxSALxxKVKGKVGI QxxxxxxxxxxxxxxxxxxxLxxSLSLxxxxxxxxxxxxxxxxxxxxxxx xxxxxxxxxxxxx------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------x xxxxxxxTPCSQANVSEPGPPSRPDDPPLLPGEKVQGVAREVTYLCPYSG PARGVLSVTNYKLHFRSMDRDTPYVVDVPLGVVSRIEKVGGASSRGENSY GIEVFCKDMRNLRFAHKQENHSRRNVFEKLQQYAFPLSHKLPLFAFEYTE SFSENGWTVHEPMAELKRMGVPNDMWKISKLNEDYEVCDTYPTVWAVPAQ ASDDDLRAVAAFRSRGRIPVLSWIHPESQATITRCSQPLVGVSGKRCRED ERYIQLIMDANAQSHKLFIMDARPSANAIANKAKGGGYESEDAYQNAELV FLDIHNIHVMRESLRKLKELCFPNIEETRWLSGVESTYWLKHIKCILAAA VRIVYKVENHKTSVLVHCSDGWDRTAQMTALPMLMLDPYYRTIKGFEVLI EKEWLSYGHKFQHRIGHGDEHHSDADRSPVFLQFIDCVWQITTQFPNAFE FNDYFLITILDHLYSCRFGTFLCNS------------------------- --------------------------------------------DRERVL EGVKQQTVSLWSYINTNMDEYRNPLYWSGNGQQHVLVPVASMRHITLWKG HYCRWNPSMRPQ-------------------------------------- -------------------------------------------------- ------DPVFQRARELLALKEQLERKVEECRREQQARAARNMATPPRLAS PIHN---- >Tcm -------------------------------------------------- -------------------------MxxRKGSSELLNSEVPRSKHAxSSD SLASDSKSSSLNSKLGQExASPAHAQVTQPHIIRDPNIYTGISAHAQATH SAAQDREIEVRISVSSGKASPPKSYTSAxSTSTENxxSALxxKVKGKxGx xxxxxxxxxxxxxxxxxxxxLxxSLSLxxxxxxxxxxxxxxxxxxxxxxx xxxxxxxxxxxxxx------------------------------------ --------VLxxxxx----------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ---------------------------------------------xxxx- -----xxTPCSQANVSEPGPPSRPDDPPLLPGEKVQGVAREVTYLCPYSG PARGVLSVTNYKLHFRSMDRDTPYVVDVPLGVVSRIEKVGGASSRGENSY GIEVFCKDMRNLRFAHKQENHSRRNVFEKLQQYAFPLSHKLPLFAFEYTE SFSENGWTVHEPMAELKRMGVPNDMWKISKLNEDYEVCDTYPTVWAVPAQ ASDDDLRAVAAFRSRGRIPVLSWIHPESQATITRCSQPLVGVSGKRCRED ERYIQLIMDANAQSHKLFIMDARPSANAIANKAKGGGYESEDAYQNAELV FLDIHNIHVMRESLRKLKELCFPNIEETRWLSGVESTYWLKHIKCILAAA VRIVYKVENHKTSVLVHCSDGWDRTAQMTALPMLMLDPYYRTIKGFEVLI EKEWLSYGHKFQHRIGHGDEHHSDADRSPVFLQFIDCVWQITTQFPNAFE FNDYFLITILDHLYSCRFGTFLCNS------------------------- --------------------------------------------DRERVL EGVKQQTVSLWSYINTNMDEYRNPLYWSGNGQQHVLVPVASMRHITLWKG HYCRWNPSMRPQ-------------------------------------- -------------------------------------------------- ------DPVFQRARELLALKEQLERKVEECRREQQARAARNMATPPRLAS PIHN---- >Tce -------------------------------------------------- -------------------------MxxRKGSSELLNSEVPRSKHA-SSD SLASDSKSSSLNSKLGQE-------------------------------- ------------SVSSGKASPPKSYTSxxSTSTEN--------------- -------------------------------------------------- -------------xxxxxxxxVTVLHVSEPDKTTRHTITLYxLIIVLMKI LLELNKGCVLxxxxx----------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ---------------------------------------------xxxx- -----xxxxxSQANVSEPGPPSRPDDPPLLPGEKVQGVAREVTYLCPYSG PARGVLSVTNYKLHFRSMDRDTPYVVDVPLGVVSRIEKVGGASSRGENSY GIEVFCKDMRNLRFAHKQENHSRRNVFEKLQQYAFPLSHKLPLFAFEYTE SFSENGWTVHEPMAELKRMGVPNDMWKISKLNEDYEVCDTYPTVWAVPAQ ASDDDLRAVAAFRSRGRIPVLSWIHPESQATITRCSQPLVGVSGKRCRED ERYIQLIMDANAQSHKLFIMDARPSANAIANKAKGGGYESEDAYQNAELV FLDIHNIHVMRESLRKLKELCFPNIEETRWLSGVESTYWLKHIKCILAAA VRIVDKVENHKTSVLVHCSDGWDRTAQMTALPMLMLDPYYRTIKGFEVLI EKEWLSYGHKFQHRIGHGDEHHSDADRSPVFLQFIDCVWQITTQFPNAFE FNDYFLITILDHLYSCRFGTFLCNS------------------------- --------------------------------------------DRERVL EGVKQQTVSLWSYINTNMDEYRNPLYWSGIGQQHVLVPVASMRHITLWKG HYCRWNPSMRPQ-------------------------------------- -------------------------------------------------- ------DPVFQRARELLVLKEQLERQVEECRREQQARAARNMATPPRLAS PIHS---- >Tbi -------------------------------------------------- -------------------------M------------------------ -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------xxxxxxxxxxxxxxx---------------- ------------ANVSEPGPPSRPDDPPLLPGEKVQGVAREVTYLCPYSG PARGVLSVTNYKLHFRSMDRDTPYVVDVPLGVVSRIEKVGGASSRGENSY GIEVFCKDMRNLRFAHKQENHSRRNVFEKLQQYAFPLSHKLPLFAFEYTE SFSENGWTVHEPMAELKRMGVPNDMWKISKLNEDYEVCDTYPTVWAVPAQ ASDDDLRAVAAFRSRGRIPVLSWIHPESQATITRCSQPLVGVSGKRCRED ERYIQLIMDANAQSHKLFIMDARPSANAIANKAKGGGYESEDAYQNAELV FLDIHNIHVMRESLRKLKELCFPNIEETRWLSGVESTYWLKHIKCILAAA VRIVDKVENHKTSVLVHCSDGWDRTAQMTALPMLMLDPYYRTIKGFEVLI EKEWLSYGHKFQHRIGHGDEHHSDADRSPVFLQFIDCVWQITTQFPNAFE FNDYFLITILDHLYSCRFGTFLCNRCYTHYTDAINNIYLFNIHYCLQPVA W------------------------------------VIPPTGxDRERAL EGVKQQTVSLWSYINTNMDEYRNPLYWSGIGQQHVLVPVASMRHITLWKG HYCRWNPSMRPQ-------------------------------------- -------------------------------------------------- ------xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx PIHS---- >Tte -------------------------------------------------- -------------------------x------------------------ -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------xxxxxxxxxxx-------------------- ------------ANVSEPGPPSRPDDPPLLPGEKVQGVAREVTYLCPYSG PARGVLSVTNYKLHFRSMDRDTPYVVDVPLGVVSRIEKVGGASSRGENSY GIEVFCKDMRNLRFAHKQENHSRRNVFEKLQQYAFPLSHKLPLFAFEYTE SFSENGWTVHEPMAELKRMGVPNDMWKISKLNEDYEVCDTYPTVWAVPAQ ASDDDLRAVAAFRSRGRIPVLSWIHPESQATITRCSQPLVGVSGKRCRED ERYIQLIMDANAQSHKLFIMDARPSANAIANKAKGGGYESEDAYQNAELV FLDIHNIHVMRESLRKLKELCFPNIEETRWLSGVESTYWLKHIKCILAAA VRIVDKVENHKTSVLVHCSDGWDRTAQMTALPMLMLDPYYRTIKGFEVLI EKEWLSYGHKFQHRIGHGDEHHSDADRSPVFLQFIDCVWQITTQFPNAFE FNDYFLITILDHLYSCRFGTFLCNRCYTHYTDAINNIYLFNIHYCLQPVA WEVALRVSHSSLMSSDRMKPRSGDWAVTIDLCPVAAx-------DRERAL EGVKQQTVSLWSYINTNMDEYRNPLYWSGIGQQHVLVPVASMRHITLWKG HYCRWNPSMRPQ-------------------------------------- -------------------------------------------------- ------DPVFQRARELLVLKEQLERQVEECRREQQVRAARNMATPPRLAS PIHS---- >Tps -------------------------------------------------- -------------------------MxxRKGSSELLNSEVPRSKHAxSSD SLASDSKSSSLNSKLGQE-------------------------------- ------------SVSSGKASPPKSYTSAxSTSTENxxSALxxKVKGK--- -------------------xLxxSLSP----------------------- ---------------------xxxxxxxxxxxxxxxxxxxxxxxxxxxxx xxxxxxxxVLxxxxx----------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ---------------------------------------------xxxx- -----xxTPCSQANVSEPGPPSRPDDPPLLPGEKVQGVAREVTYLCPYSG PARGVLSVTNYKLHFRSMDRDTPYVVDVPLGVVSRIEKVGGASSRGENSY GIEVFCKDMRNLRFAHKQENHSRRNVFEKLQQYAFPLSHKLPLFAFEYTE SFSENGWTVHEPMAELKRMGVPNDMWKISKLNEDYEVCDTYPTVWAVPAQ ASDDDLRAVAAFRSRGRIPVLSWIHPESQATITRCSQPLVGVSGKRCRED ERYIQLIMDANAQSHKLFIMDARPSANAIANKAKGGGYESEDAYQNAELV FLDIHNIHVMRESLRKLKELCFPNIEETRWLSGVESTYWLKHIKCILAAA VRIVYKVENHKTSVLVHCSDGWDRTAQMTALPMLMLDPYYRTIKGFEVLI EKEWLSYGHKFQHRIGHGDEHHSDADRSPVFLQFIDCVWQITTQFPNAFE FNDYFLITILDHLYSCRFGTFLCNS------------------------- --------------------------------------------DRERVL EGVKQQTVSLWSYINTNMDEYRNPLYWSGNGQQHVLVPVASMRHITLWKG HYCRWNPSMRPQxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxSAGTA GExxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx- -------------------------------------------------- -------- >Tdi RGTADHLSNERSRRVAHYIVARRTVSAVVVRSLVSRVRHQLGGNDLQMTL PRSVKDTLLLSSISVCSCIxxxxxx------SSELLNSEVPRSKHAxSSD SLASDSKSSSLNSKLGQE-------------------------------- ------------SVSSGKASPPKSYTSxxSTSTENxxSALxxKVKGK--- -------------------xLxxxxxx----------------------- ---------------------VTVLHVFEPDKTTGHTIMLDALIMVLMEI LLELNERCVLxxxxx----------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ---------------------------------------------xxxx- -----xxxxxSQANVSEPGPPSRPDDPPLLPGEKVQGVAREVTYLCPYSG PARGVLSVTNYKLHFRSMDRDTPYVVDVPLGVVSRIEKVGGASSRGENSY GIEVFCKDMRNLRFAHKQENHSRRNVFEKLQQYAFPLSHKLPLFAFEYTE SFSENGWTVHEPMAELKRMGVPNDMWKISKLNEDYEVCDTYPTVWAVPAQ ASDDDLRAVAAFRSRGRIPVLSWIHPESQATITRCSQPLVGVSGKRCRED ERYIQLIMDANAQSHKLFIMDARPSANAIANKAKGGGYESEDAYQNAELV FLDIHNIHVMRESLRKLKELCFPNIEETRWLSGVESTYWLKHIKCILAAA VRIVYKVENHKTSVLVHCSDGWDRTAQMTALPMLMLDPYYRTIKGFEVLI EKEWLSYGHKFQHRIGHGDEHHSDADRSPVFLQFIDCVWQITTQFPNAFE FNDYFLITILDHLYSCRFGTFLCNS------------------------- --------------------------------------------DRERVL EGVKQQTVSLWSYINTNMDEYRNPLYWSGNGQQHVLVPVASMRHITLWKG HYCRWNPSMRPQxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxSAGTA GExxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx AENKRQDP------------------------------------------ ---SKSLG >Tpa -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------VSSGKASPPKSYTSASSTSTENxxSALxxKVKGK--- -------------------------------------------------- -------------------------------------------------- -----------------xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx xxxxxxxxxxxxxxxxxxxx------------------------------ -------------------------------------------------- -------------------------------------------------- ------------------GPPSRPDDPPLLPGEKVQGVAREVTYLCPYSG PARGVLSVTNYKLHFRSMDRDTPYVVDVPLGVVSRIEKVGGASSRGENSY GIEVFCKDMRNLRFAHKQENHSRRNVFEKLQQYAFPLSHKLPLFAFEYTE SFSENGWTVHEPMAELKRMGVPNDMWKISKLNEDYEVCDTYPTVWAVPAQ ASDDDLRAVAAFRSRGRIPVLSWIHPESQK-------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------xxxPxxPMAAM-------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- --------