>Tge xxxxx--------------------------------------------- -------------------------------------------------- -------------------------------------------------- ---------------------------------------------R---- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ----------------------------------------NFPSHRVQEV WTQMVQKGVKGEYLRDILMFYLQHILFPPLDQQSYNALLLTFSAKGVNKK MKNVIFQILEEISLYVQNSITETVRFSSNSFATVELLSVIQVGGLVPLVD VSTVNKLVRLLEDNDLGHGEKGKVLFFLCQAAGLFPDVIYMDHVVRLNRL LSSWLWTPLTPISAGSQLFGRSESAATEVDGSPAADIFTVLTI------- ----------------------VNIFNNSQMMNVHTFSVIREWLDHMPES SSDQTVEHALLLDAVKEYCDIVVEQCFRKAQKEDVGLQKAVMCEVLNIIH RVVQLDRSRAPKTLILVKRIYTHISDRFKSDHRDISILVRVFRFLLEFGD STGYTPQHLYELFLGETLYRCYSSGLAAWDIALFLCEQHNKLELLLSRFF PNILKLVACHPAALVEEFLHLLPAMISSANTIELFSSLLDLPLLSATLLL HQAPAVVQLDVASPLWVRLLESVSNPAHQLHYTYLLRKESGKMDPPG--- ------------------RLSSYLGVLADLRVHPLVITCSEVTPLLIDVF LSAVEHQGNPHSLAEVLITMLRKVNKLYNVDGYPAAVYKILSKHLRQIVH LCPDGLLTNENEVSTYLSILDNCDTALDFYTHLVWAVGELASSTKSAHCN NYDVMTRLYETVESALYEILGQLSSKCVSLKLINIMAATLAKLASRCEDL IPRVMLCFHKASTGISNTGLPTVDKQIVLSRMDELACILRNPSTAASVLT SSREEDPALSAV-------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------xxxx--- -------------------------------------------------- xxxx---------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -----------------------------xx >Tbi x------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ---------------------------------------------x---- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ----------------------------------------xxPSHRVQEV WTQMVQKGVKGEYLRDILMFYLQHNLFPPLDQQSYNALLLTFSAKGVNKK MKNVIFQILEEISLYVQNSITETVRFSSNTFATVELLSVIQVGGLVPLVD VSTVNKLLRLLEDNDLQHGEKGKVLFFLCQAAGLFPDVISVDHVVRLNRL LSSWLWTPLAPISAGSQLFGRSESAATEVDGSPAADIFTVLTI------- ----------------------VNIFNNSQMMNVHTFSVIREWLDHMPES SSDQTVEHALLLDAVKEYCDIVVEQCFRKAQKEDVGLQKAVMCEVLNIIH RVVQLDRSRAPKTLILVKRIYTHISDRFKSDHRDISILVRVFRFLLEFGD STGYTPQHLYELFLGETLYRCYSSGLAAWDIALFLCEQHNKLELLLSRFF PNILKLVACHPAALVEEFLHLLPAMISSANTIELFSSLLDLPLLSATLLL HQAPAVVQLDVASPLWVRLLESVSNPAHQLHYTYLLRKESGKMDPPG--- ------------------R------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ------------------------------- >Tpa x------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ---------------------------------------------xxxxx -------------------------------------------------- -------------------------------------------------- ----xxxxxxxxxxxxxxxxxxxxxxx-------------------xxxx xxxxxxxxxxxxxxx--------------------xxxxxNFPSHRVQEV WTQMVQKGVKGEYLRDILMFYLQHNLFPPLDQQSYNALLLTFSAKGVNKK MKNVIFQILEEISLYVQNSITETVRFSSNSFATVELLSVIQVGGLVPLVD VSTVNKLVRLLEDNDLGHGEKGKVLFFLCQAAGLFPDVISVDHVVRLNRL LSSWLWTPLAPISAGSQLFGRSESAATEVDGSPAADIFTVLTI------- ----------------------VNIFNNSQMMNVHTFSVIREWLDHMPES SSDQTVEHALLLDAVKEYCDIVVEQCFRKAQKEDVGLQKAVMCEVLNIIH RVVQLDRSRAPKTLILVKRIYTHISDRFKSDHRDISILVRVFRFLLEFGD STGYTPQHLYELFLGETLYRCYSSGLAAWDIALFLCEQHNKLELLLSRFF PNILKLVACHPAALVEEFLHLLPAMISSANTIELFSSLLDLPLLSATLLL HQAPAVVQLDVASPLWVRLLESVSNPAHQLHYTYLLRKESGKMDPPG--- ------------------RLSSYLGVLADLRVHPLVITCSEVTPLLIDVF LSAVEHQGNPHSLAEVLITMLKKVNKLYNVDGYPAAVYK----------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -----------------------------xx >Tdi MLIHxxxxxxxxxxxxLExxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx xxxxxxxxxxxxFxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx---- -------------------------------------------------- ----------------xxxxxxxxxxxxxxxxxxxxxxxxxxxxxM---- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ----------------------------------------NFPNHRVQEL WTQMVQKGVKGEYLRDILMFYLQHNLFPPLDQQSYNALLLTFSAKGVNKK MKNVIFQILEEISLYLQNSIAETVRFSSNTFATAELLSVIQVGGLVPLLD VSTVDKLVRLLEDNDLRHGEKGKVLFFLCQATGHFPDVISMDHVVKLNRL LSSWLWTPLTPISAGSQLFGRFESAATEVDGSPAADIFTVLTI------- ----------------------VNIFNNSQMMNVHTFSVIREWLNHVPES SSNQTVEHALLLDAVKEYCNIVVEQCFRKAQKEDVGLQKAVMCEVLNIIH RVVQLDRSRAPKTLILVKRIYTHISDRFKSDHRDISILVRVFRFLLEFGD STGYTPQHLYELFLGETLYRCYSSGLAAWDIAVFLCEQHNKLELLLSRFF PNILKLVACHPAALVEEFLHLLPAMISSANTMELFSSLLDLPLLSATLLL HQAPAVVQLDVSSPLWGKLLESVSNPAHQLHYTYLLRKESGKMDPPG--- ------------------RLSSYLEVLADLRVHPLVMTCSEVTPLLIDVF LSAVEHQGNPHSLAEVLITMLRKVNKLYNVDGYPAAVYKILSKHLRQIVQ LCPDGLLTNENEVSTYLSILDNCDTALDFYTHLVWAVGELASSTK----- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ------------------------------x >Tsi x------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ---------------------------------------------x---- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ----------------------------------------NFPNHRVQEV WTQMVQKGVKGEYLRDILMFYLQHNLFPPLDQQSYNALLLTFSAKGVNKK MKN----ILEEISLYLQNSIAETVRFSSNTFATAELLSVIQVGGLVPLLD VSTVDKLVRLLEDNDLRHGEKGKVLFFLCQATGHFTDVISMDHVVRLNRL LSSWLWTPLTPISAGSQLFGRFESVATEVDGSPAADIFTVLTI------- ----------------------VNIFNNSQMMNVHTFSVIREWLNHVPES SSNQTVEHALLLDAVNEYCSIVVEQCFRKAQKEDVGLQKAVMCEVLNIIH RVVQLDRSRAPKTLILVKRIYTHISDRFKSDHRDISILVRVFRFLLEFGD STGYTPQHLYELFLGETLYRCYSSGLAAWDIAVFLCEQHNKLELLLSRFF PNILKLVACHPAALVEEFLHLLPAMISSANTMELFSSLLDLPLLSATLLL HQAPAVVQLDVASPLWGKLLESVSNPAHQLHYTYLLRKESGKMDPPG--- ------------------RLSSYLEVLADLRVHPLVMTCSEVTPLLIDVF LSAVEHQGNPHSLAEVLITMLRKVNKLYNVDGYPAAVYKILSKHLHQIVQ LCPDGLLTNENAVSTYLSILDNCDTALDFYTHLVWAVGELASSTKSAHCN NYDVMTRLYETVESALYEILGKLSSKCVSLKLINIMAATLAKLASRCEDL IPRVMLCFHKVSTGISNTGLPTVDKQIVLSRVDELACILRNPTIAASVLT SSREEDPALSAV-----xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxV xxxExxxxxxxxxxxxxxxxxxxxxxMALMVxxxxxxxxxxARRIYSxxx PRxxxxxxxxxxxPFTELSDDxxxxSSxxxxxxxxxxxxxxxxxxxxxxx xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx xxxxxLxxxxxxxxxxxxxxxxxxxNxxxxxxxxxxxxxPxxxxGAAQFV ACFGLISILEFLxxxxxxxSCSIPDIYTRANxxFISSSVAPLWKIKAASL NNITFQSVNCDxxxxAELPPFDxMKTEFGKxSLCAFxxxxxxxxxxxxFL WAVLFTxxxxxxxxxxxxxxxxxIVYPALIFNFLYLIISTTSSVLLEQGH DAFCDSFMVNMNETSCSNMDKYCVSSWTLSQITYxxVRHxQGVVISPGPR LKTSSWFNMLAWLLATVLLLxxxxxxxDFEVIKITIHTPEPDHDEEAPxx xIxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx------ -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ------------------------------- >Tps x------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- --------------------------xxxxxxxxxxxxxxxxxxxxx--- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ----------------------VNIFNNSQMMNVHTFSVIREWLNHVPES SSNQTVEHALLLDAVKEYCNIVVEQCFRKAQKEDVGLQKAVMCEVLNIIH RVVQLDRSRAPKTLILVKRIYTHISDRFKSDHRDISILVRVFRFLLEFGD STGYTPQHLYELFLGETLYRCYSSGLAAWDIAVFLCEQHNKLELLLSRFF PNILKLVACHPAALVEEFLHLLPAMISSANTMELFSSLLDLPLLSATLLL HQAPAVVQLDVASPLWGKLLESVSNPAHQLHYTYLLRKESGKMDPPG--- ------------------R------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ------------------------------- >Tcm MLIxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ------QILEEISLYLQNSIAETVRFSSNTFATAELLSVIQVGGLVPLLD VSTVDKLVRLLEDNDLRHGEKGKVLFFLCQATGHFPDVISMDHVVRLNRL LSSWLWTPLTPISAGSQLFGRFESAATEVDGSPAADIFTVLTI------- ----------------------VNIFNNSQMMNVHTFSVIREWLNHVPES SSNQTVEHALLLDAVNEYCSIVVEQCFRKAQKEDVGLQKAVMCEVLNIIH RVVQLDRSRAPKTLILVKRIYTHISDRFKSDHRDISILVRVFRFLLEFGD STGYTPQHLYELFLGETLYRCYSSGLAAWDIAVFLCEQHNKLELLLSRFF PNILKLVACHPAALVEEFLHLLPAMISSANTMELFSSLLDLPLLSATLLL HQAPAVVQLDVASPLWGKLLESVSNPAHQLHYTYLLRKESGKMDPPG--- ------------------RLSSYLEVLADLRVHPLVMTCSEVTPLLIDVF LSAVEHQGNPHSLAEVLITMLRKVNKLYNVDGYPAAVYKILSKHLHQIVQ LCPDGLLTNENAVSTYLSILDNCDTALDFYTHLVWAVGELASSTKSAHCN NYDVMTRLYETVESALYEILGKLSSKCVSLKLINIMAATLAKLASRCEDL IPRVMLCFHKVSTGISNTGLPTVDKQIVLSRVDELACILRNPTIAASVLT SSREEDPALSAVxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxV xxxxxxxxxxxxxx------------------------------------ -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ------------------------------x >Tms x------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ------------------------xxx-------------------xxxx xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx----NFPSHRVQEV WTQMVQKGVKGEYLRDILMFYLQHNLFPPLDQQSYNALLLTFSAKGVNKK TKN----ILEEISLYLQNSIVETVRFSSNTFATAELLSVVQVGGLLPLLD VSTVDKLVRLLEDNDLRHGEKGKVLFFLCQAAGLFPDLISMDHVVRLNRL LSSWLWTPLTPMSTGSQLFGRFESAATEVDGSPAADIFTVLTI------- ----------------------VNIFNNSQMMNVHTFSVIKEWLNNVPES SSDQTVEHALLLDAVKEYCNIVVEQCFRKAQKEDVGLQKAVMCEVLNIIH RVVQLDRSRASKTLILVKRIYTHISDRFKSDNRDISILVRVFRFLLEFGD STGYTPQHLYELFLGDTLYRCYSSGLAAWDIAVFLCEQHNKLELLLSRFF PNILKLVACHPAALVEEFLHLLPAMISSANAMELFSSLLDLPLLSATLLL HQAPAVVQLDVASPLWSRLLESVSNPAHQLHYTYLLRKESGKMDTPG--- ------------------RFSSYLEVLADLRVHPLVMTCSEVTPLLIDVF LSAVEHQGNPLSLAEVLITMLRKVNKLYNVDGYPAAVYKILSKHLRQIVQ LCPEGLLTNENEVSTYLSILDNCDTALDFYTHLVWAVGELASSTKSAHCN NYDVMTRLYETVESALYEILGQLSSKCVSLKLINIMAATLAKLASRCEDL IPRVMLCFHKVSTGISNTGLPTVDKQIVLSRVDELACILRNPTIAASVLT TSREEDPALSAVx------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ---xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx xxxxxxxxxxxxxxxxxxxxxRxxxxxxxxxSTHGTLNDTxxKxxxxxxx xxxxFHTWxxxxxxxNQxxxANSERTNQKIDVKLEKINNELGETRQEIID AIxxxxAKLNKFNDQLGARxxxxxxxxxxxxxTTIQxxxxxxTTIRSVxx xxxxxxxxxxxxxxxEIEPETTTRSVIEPELRSNPxSKQKKRSxxxxNKR xxSSPRLNQRLGDSTYFHHVDQMRPVxxxxx >Tce M------------------------------------------------- ---------------------------------------------xxxxx xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx xxxxxxxxxxxxxxxxx----------------------------R---- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ----------------------------------------NFPSHRVQEV WTQMVQKGVKGEYLRDILMFYLQHNLFPPLDQQSYNALLLTFSAKGVNKK MKN----ILEEISLYLQNSIAETVRFSSNTFATAELLSVIQVGGLLPLLD VSTVDKLVRLLEDNDLWHGEKGKVLFFLCQAAGLFPDLISMDHVVRLNRL LSSWLWTPLTPMSTGSQLFGRFESAATEVDGSPAADIFTVLTIEMATFPF LRAKRVSPLRRLPSTCHLNEESVNIFNNSQMMNVHTFSVIKEWLNNVPES SSDQTVEHALLLDAVKEYCNIVVEQCFRKAQKEDVGLQKAVMCEVLNIIH RVVQLDRSRASKTLILVKRIYTHISDRFKSDNRDISILVRVFRFLLEFGD STGYTPQHLYELFLGDTLYRCYSSGLAAWDIAVFLCEQHNKLELLLSRFF PNILKLVACHPAALVEEFLHLLPAMISSANAMELFSSLLDLPLLSATLLL HQAPAVVQLDVASPLWSRLLESVSNPAHQLHYTYLLRKESGKMDTPGxHN IQPSGSKGGTHISPVINCRFSSYLEVLADLRVHPLVMTCSEVTPLLIDVF LSAVEHQGNPHSLAEVLITMLRKVNKLYNVDGYPAAVYKILSKHLRQIVQ LCPEGLLTNENEVSTYLSILDNCDTALDFYTHLVWAVGELASSTKSAHCN NYDVMTRLYETVESALYEILGQLSSKCVSLKLINIIAATLAKLASRCEDL IPRVMLCFHKVSTGISNTGLPTVDKQIVQSRVDELACILRNPTIAASVLT SSREEDPALSAV-------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ----------------------------------------------xxxx xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxLQxxNK x------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ------------------------------- >Tte x------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------x xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx xxxxx--------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------ILEEISLYVQNSITETVRFSSNTFATVELLSVIQVGGLVPLVD VSTVNKLLRLLEDNDLQHGEKGKVLFFLCQAAGLFPDVISVDHVVRLNRL LSSWLWTPLAPISAGSQLFGRSESAATEVDGSPAADIFTVLTI------- ----------------------VNIFNNSQMMNVHTFSVIREWLDHMPES SSDQTVEHALLLDAVKEYCDIVVEQCFRKAQKEDVGLQKAVMCEVLNIIH RVVQLDRSRAPKTLILVKRIYTHISDRFKSDHRDISILVRVFRFLLEFGD STGYTPQHLYELFLGETLYRCYSSGLAAWDIALFLCEQHNKLELLLSRFF PNILKLVACHPAALVEEFLHLLPAMISSANTIELFSSLLDLPLLSATLLL HQAPAVVQLDVASPLWVRLLESVSNPAHQLHYTYLLRKESGKMDPPG--- ------------------RLSSYLGVLADMRVHPLVITCSEVTPLLIDVF LSAVEHQGNPHSLAEVLITMLKKVNKLYNVDGYPAAVYKILSKHLRQIVH LCPDGLLTNENEVSTYLSILDNCDTALDFYTHLVWAVGELASSTKSAHCN NYDVMTRLYETVESALYEILGQLSSKCVSLKLINIMAATLAKLASRCEDL IPRVMLCFHKASTGISNTGLPTVDKQIVLSRMDELACILRNPSTAASVLT SSREEDPALSAV-------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- 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