>Tge -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- --------x-----------------------------xx----xxxxxx xxSVTSEKIRDIFGEKGIVTDVQLKYTKDGKFRRFGFVGFKTPEDANNAI NYFNNNFINASRIQVELCAGLGDPQKPKAWSKYAPDSSAFKKIHNPEEKK VNKKEQKKKKSDKNLNNGVKEVLEK----------------LSNALVVLS STAEDGEIEVRIxHKDDPLFAEFMEAHGKGAKAVWSNNADVSAEAVEIVE RTTSQSDKDSDYNTDDDGDAEQKEGSDSNEKSLAKANISDLDYLKTKIVD PLEISEASLDDETSSGAKKTPRKPKEKEPKAPVTLFTVKVRGLPYKAKKK DVKQFFHPLKSKTIRIPRKMKGFVYIGFRTEKEMKQALLKNMSFL----- -----xxxxxSEMRIFFLITxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx xxxxxxxxVLVSVxxxx-------------TGRRILVTQSVSKESSSISK NEPSVSKWKDQEENLKHEETIAESGRIFVRNLSFTVTEEELTELLR---P LAELIMPVDRLSRKAKGFALVTFVIPENASTAYTELDGSVFHGRMLHLLP GKAKQSIEELLEQ-EGLTYQQKQKLKQKSQAASSHNWNTLFLGQNAVADL IAENYNTTK----------------EQVLDSSGKASIAVRLALGETQIVS QMREFLEESGVRLDAFNQAPKQRSKTTILIKNLPAKTSASEIRELFAKHG ELGRVVLPTAGVTA------------------------------------ -------------------------------------------------- ------------------------------IVEFLEPSEARNAFTKLAYS RFKHLPLYLEWAPSETFAAPYSKEKPLKKEVSKLNEQSAAGDKATETEVD GEATDDDEDPEPDTTLFIKNLNFETREDSVKE------------------ ----HFKKCGPIHYVTVALKKDPKKPGELLSMGYGFIQFKKKASADKALK TLQQSVLEGFSVELKRSNRTLQ---------------------------- --------------SDVATARKTTKVGKQVGSKILVRNLPFQATRQEVID LFKTFGEIKAVRLPKKMVGTGPHRGFAFVDYLTKHDAKRAFKALCQSTHL YGRRLVLEWATSEEDVDEIRKRTAQHFLDEPPSIKNLRKSTIDPEDIGEG LD------------------------------------------------ -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- --------------------- >Tte M------------------------------------------------- -------------------------------------------------- ---------------------------------------------xxxxx xx----xx------------------------------------------ -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------GRRILVTQSVSKESSSISK NEPSVSKWKDQEENLKHEETIAESGRIFVRNLSFTVTEEELTELLSKYGP LAELIMPVDRLSRKAKGFALVTFVIPENASTAYTELDGSVFHGRMLHLLP GKAKQSIEELLEQ-EGLTYQQKQKLKQKSQAASSHNWNTLFLGQNAVADL IAENYNTTK----------------EQVLDSSGKASIAVRLALGETQIVS QMREFLEESGVRLDAFNQAPKQRSKTTILIKNLPAKTSASEIRELFAKHG ELGRVVLPTAGVTA------------------------------------ -------------------------------------------------- ------------------------------IVEFLEPSEARNAFTKLAYS RFKHLPLYLEWAPSETFAAPYSKEKPLKKEVSKLNEQSAAGDKATETEVN GEATDDDEDPEPDTTLFIKNLNFETREDSVKE------------------ ----HFKKCGPIHYVTVALKKDPKKPGELLSMGYGFIQFKKKASADKALK TLQQSVLEGFSVELKRSNRTLQ---------------------------- -------------------------------------------------- ---TFGEIKAVRLPKKMVGTGPHRGFAFVDYLTKHDAKRAFKALCQSTHL YGRRLVLEWATSEEDVDEIRKRTAQHFLDEPPSIKNLRKSTIDPEDTGEG LD------------------------------------------------ -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- --------------------- >Tms MxxxxxACHCSKPSSKDVHPxEIRTSISPSSAVELxxxxALANYATEADL KVARTNSTAPATSNDCVTSSFMTLSLSE---------------------- --------HIAFSSSAPFSSGLALIPFQIRCFTEExxKHRGxxxxH---- --------LGSVD---RNSDQYTTxxxxxxxxxxxxxxx----------- ------EKIRDIFGEKGIVTDVQLKYTKDGKFRRFGFVGFKTPEDANNAI NYFNNNFINASKIQVELCAGLGDPQKPKAWSKYAPDSSAFKKIHELAEKK VNKKEQKKKKLDKNLNNGVKEVLEKVKNFHDHKFRPASVAYLADALVVLS STSEDGEI----xHKDDPLFAEFMEAHGKGAKAVWSNNAVVGAEAVEIIE RTTSQPDKDSDYNTDDDGDAEEREELDSNDKSLAKANISDLDYLKTKIVD PLESSESSPDDETSSDAKKTPKKPKEKEPKAPVTLFTVKVRGLPYKAKKK DVKQFFHPLKSKTIRFPRKIKGFVYIGFRTEKEMKQALLKNMSFLESTDS YPNTSG-------------------------------------------- ----------------AxGTIAxxNCxxVFTGKRILVTQSVSKESSSKSK NEPSVSKWKDQEETLKHEETIAESGRIFVRNLSFTVTEEELTELLSKYGP LAELIMPVDRLSRKAKGFALVTFVIPENASTAYTELDGSVFHGRMLHLLP GKAKQSIEELLEQ-EGLTYQQKQKLKQKSQAASSHNWNTLFLGQNAVADL IAENYNTTK----------------EQVLDSSGKASVAVRLALGETQIVS QMREFLEESGVRLDAFNQAPKQRSKTTILIKNLPAKTSASEIRELFAKHG ELGRVVLPTAGVTA------------------------------------ -------------------------------------------------- ------------------------------IVEFLEPSEAKNAFTKLAYS KFKHLPLYLEWAPSETFAVPFSKEKPLKKEVSKLNEQAAAGEKAAETEVD GEATDDDEDPEPDTTLFIKNLNFETREDSVKE------------------ ----HFKKCGPIHYVTVALKKDPKKPGELLSMGYGFIQFKKKASADKALK TLQQSVLEGFSVELKRSNRTLHGSIVKSVVLFSSGSIVKSVVLFLKWQHC KECVNSLPSRSSVKSDVATAKKTTKVGKQVGSKILVRNIPFQATRQEVFD LFKTFGEIKAVRLPKKMVGTGPHRGFAF----------RAFKALCQSTHL YGRRLVLEWATAEEDVDEIRKRTAQHFLDEPPGVKNLRKSTIDPEDIEEG LD------------------------------------------------ -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- --------------------- >Tce x------------------------------------------------- -------------------------------------------------- -------------------------------------------------- --------------------------------------xxxxxxx----- --QVTSEKIRDIFGEKGIVTDVQLKYTKDGKFRRFGFVGFKTPEDANNAI NYFNNNFINASKIQVELCAGLGDPQKPKAWSKYAPDSSAFKKIHEPAEKK VNKKEQKKKKLDKNLNNGVKEVLEK------------------------- -------------HKDDPLFAEFMEAHGKGAKAVWSNNAVVGAEAVEIIE RTTSQPDKDSDYNTDDDGDAEEREELDSNDKSLAKANISDLDYLKTKIVD PLERSESSLDDETSSDAKKTPKKPKEKEPKAPVTLFTVKVRGLPYKAKKK DVKQFFHPLKSKTIRFPRKIKGFVYIGFRTEKEMKQALLKNMSFL----- -------------------------------------------------- ------------------------------AGKRILVTQSVSKESSSKSK NEPSVSKWKDQEETLKHEETIAESGRIFVRNLSFTVTEEELTELLSKYGP LAELIMPVDRLSRKAKGFALVTFVIPENASTAYTELDGSVFHGRMLHLLP GKAKQSIEELLEQ-EGLTYQQKQKLKQKSQAASSHNWNTLFLGQNAVADL IAENYNTTK----------------EQVLDSSGKASVAVRLALGETQIVS QMREFLEESGVRLDAFNQAPKQRSKTTILIKNLPAKTSASEIRELFAKHG ELGRVVLPTAGVTA------------------------------------ -------------------------------------------------- ------------------------------IVEFLEPSEAKNAFTKLAYS KFKHLPLYLEWAPSETFAVPFSKEKPLKKEVSKLNEQAAAGEKTVETEVD GEATDDDEDPEPDTTLFIKNLNFETREDSVKE------------------ --------------------KDPKKPGELLSMGYGFIQFKKKASADKALK TLQQSVLEGFSVELKRSNRTLQ---------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- --------------------- >Tbi M------------------------------------------------- -------------------------------------------------- -------------------------------------------------- --------------------------------------xx----xxxxxx xxSVTSEKIRDIFGEKGIVTDVQLKYTKDGKFRRFGFVGFKTPEDANNAI NYFNNNFINASRIQVELCAGLGDPQKPKAWSKYAPDSSAFKKIHNTEEKK VNKKEQKKKKSDKNLNNGVKEVLEK------------------------- -------------HKDDPLFAEFMEAHGKGAKAVWSNNAVVGAEAVEIVE RTTSQSDKDSDYNTDDDGDAEEKEGSDSNDKSLAKANISDLDYLKTKIVD PLESSEASLDDETSSGAKKTPRKPKEKEPKAPVTLFTVKVRGLPYKAKKK DVKQFFHPLKSKTIRIPRKMKGFVYIGFRTEKEMKQALLKNMSFL----- -------------------------------------------------- ------------------------------AGRRILVTQSVSKESSSISK NEPSVSKWKDQEENLKHEETIAESGRIFVRNLSFTVTEEELTELLSKYGP LAELIMPVDRLSRKAKGFALVTFVIPENASTAYTELDGSVFHGRMLHLLP GKAKQSIEELLEQAEGLTYQQKQKLKQKSQAASSHNWNTLFLGQNAVADL IAENYNTTKxQVGPHTCISFVCAADEQVLDSSGKASVAVRLALGETQIVS QMREFLEESGVRLDAFNQAPKQRSKTTILIKNLPAKTSASEIRELFAKHG ELGRVVLPTAGVTA------------------------------------ -------------------------------------------------- ------------------------------IVEFLEPSEARNAFTKLAYS RFKHLPLYLEWAPSETFAAPYSKEKPLKKEVSKLNEQSAAGDKATETEVN GEATDDDEDPEPDTTLFIKNLNFETREDSVKE------------------ ----HFKKCGPIHYVTVALKKDPKKPGELLSMGYGFIQFKKKASADKALK TLQQSVLEGFSVELKRSNRTLQ---------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- --------------------- >Tsi M------------------------------------------------- -------------------------------------------------- -------------------------------------------------- --------------------------------------xx----xxxxxx xxSVTSEKIRDIFGEKGIVTDVQLKYTKDGKFRRFGFVGFKTPEDANNAI NYFNNNFINASKIQVELCAGLGDPQKPKAWSKYAADSSAFKKIHDPGEKK VNKKEKKKKKSDKILNNGVKEVLEK------------------------- -------------HKDDPLFAEFLEAHGKGAKAVWSNNAVVSAEAVDIVE RTTSQPDKDSDYNTDDDGEAEEKEGLDSNDKSLARANISDLDYLKTKIVD PLESSEASLDDEPSSGAKKTPKKPKEKEPKAPVTLFTVKVRGLPYKAKKK DVKQFFHPLKSKTIRFPRKMKGFVYIGFRTEKEMKQALLKNMSFLESTDS YPNTSG-------------------------------------------- ----------------ALDIFAxxSCxxAFTGKRILVTQSISKESSSKSK NEPTVSKWKDQEENLKHEESIAESGRIFVRNLSFTVTEEELTELLSKYGP LAELIMPVDRLSRKAKGFALVTFVIPENASTAYTELDGSVFHGRMLHLLP GKAKQSIEELLEQAEGLTYQQKQKLKQKSQAASSHNWNTLFLGQNAVADL IAENYNTTK----------------EQVLDSSGKASVAVRLALGETQIVS QMREFLEESGVRLDAFNQAPKLRSKTTILIKNLPTKTSASEIRELFAKHG ELGRVVLPTAGVTA------------------------------------ -------------------------------------------------- ------------------------------IVEFLEPSEAKNAFTKLAYS KFKHLPLYLEWAPSETFTAPFSKEKPLKKEVSKLNEQPAAGEKAAETEAD DEATDDDEDPEPDTTLFIKNLNFETREDSVKE------------------ ----HFKKCGPIHYVTVALKKDPKKPGELLSMGYGFIQFKKKASADKALK TLQQSVLEGFSVELKRSNRTLQ---------------------------- --------------SDVATAKKTSKVGKQVGSKILVRNIPFQATRQEVFD LFKTFGEIKAVRLPKKMVGTGPHRGFAFVDYLTKHDAKRAFKALCQSTHL YGRRLVLEWATSEEDVDEIRKRTAQHFLDEPPGVKNLRKSTIDPEDIEEA LD------------------------------------------------ -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- --------------------- >Tcm x------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ------------xxxxx---------------------x----------- -------------------------------------------------- ----------------------DPQKPKAWSKYAADSSAFKKIHDPGEKK VNKKEKKKKNSDKILNNGVKEVLEK------------------------- -------------HKDDPLFAEFLEAHGKGAKAVWSNNAVVSAEAVDIVE RTTSQPDKDSDYNTDDDGEAEEKEGLDSNDKSLARANISDLDYLKTKIVD PLESSEASLDDEPSSGAKKTPKKPKEKEPKAPVTLFTVKVRGLPYKAKKK DVKQFFHPLKSKTIRFPRKMKGFVYIGFRTEKEMKQALLKNMSFLESTDS YPNTSG-------------------------------------------- ----------------ALDIFASLSCLHAFTGKRILVTQSVSKESSSKSK NEPTVSKWKDQEESLKHEESIAESGRIFVRNLSFTVTEEELSELLR---P LAELIMPVDRLSRKAKGFALVTFVIPENASTAYTELDGSVFHGRMLHLLP GKAKQSIEELLEQ-EGLTYQQKQKLKQKSQAASSHNWNTLFLGQNAVADL IAENYNTTK----------------EQVLDSSGKASVAVRLALGETQIVS QMREFLEESGVRLDAFNQAPKQRSKTTILIKNLPAKTSASEIRELFAKHG ELGRVVLPTAGVTA------------------------------------ -------------------------------------------------- ------------------------------IVEFLEPSEAKNAFTKLAYS KFKHLPLYLEWAPSETFTAPFSKEKPLKKEVSKLNEQPAAGEKAAETEAD DEATDDDEDPEPDTTLFIKNLNFETREDSVKELANALVVLSLTAEDREIE VPIxHFKKCGPIHYVTVALKKDPKKPGELLSMGYGFIQFKKKASADKALK TLQQSVLEGFSVELKRSNRTLQ---------------------------- --------------SDVATAKKTSKVGKQVGSKILVRNIPFQATRQEVFD LFKTFGEIKAVRLPKKMVGTGPHRGFAFVDYLTKHDAKRAFKALCQSTHL YGRRLVLEWATSEEDVDEIRKRTAQHFLDEPPGVKNLRKSTIDPEDIEEA LD------------------------------------------------ -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- --------------------- >Tdi x------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ------------xxxxx---------------------x----------- -------------------------------------------------- ----------------------DPQKPKAWSKYAADSSAFKKIHDPGEKK VNKKEQKKKKSDKNLNNGVKEVLEK------------------------- -------------HKDDPLFAEFLEAHGKGAKAVWSNNAVVSAEAVDIVE RTTSQPDKDSDYNTDDDGDTEEKEGLDSNDKSLAKANISDLDYLKTKIVD PLESSEASLDDEPSSGAKKTPKKPREKEPKAPVTLFTVKVRGLPHKAKKK DVKQFFHPLKSKTIRFPRKIKGFVYIGFRTEKEMKQALLKNMSFL----- -------------------------------------------------- ------------------------------AGKRILVTQSVSKKSSSKSK NEPTISKWKDQEDNLKHEETIAESGRIFVRNLSFTVTEEELTELLSKYGP LAELIMPVDRLSRKAKGFALVTFVIPENASTAYTELDGSVFHGRMLHLLP GKAKQSIEELLEQ-EGLTYQQKQKLKQKSQAASSHNWNTLFLGQNAVADL IAENYNTTK----------------EQVLDSSGKASVAVRLALGETQIVS QMREFLEESGVRLDAFNQAPKQRSKTTILIKNLPAKTSDSEIRELFAKHG ELGRVVLPTAGVTA------------------------------------ -------------------------------------------------- ------------------------------IVEFLEPSEAKNAFTKLAYS KFKHLPLYLEWAPSETFAAPFSKEKLLKKKVSKLNEQTAAGEKATETEAD EEATDDDEDPEPDTTLFIKNLNFETREDSVKE------------------ ----HFKKCGPIHYVTVALKKDPKKPGELLSMG----------------- -------------------------------------------------- --------------SDVATAKKTSKVGKQVGSKILVRNIPFQATRQEVFD LFKTFGEIKAVRLPKKMVGTGPHRGFAFVDYLTKHDAKRAFKALCQSTHL YGRRLVLEWATSEEDVDEIRKRTAQHFLDEPPGVKNLRKSTIDPEDIEEG LD------------------------------------------------ -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- --------------------- >Tps M------------------------------------------------- ---------------------------xxxxxxxxxSLPDRDSNLDLxxx xxxxxxxxx----------------------------------------- -------------------------------------------------- ---VTSEKIRDIFGEKGIVTDVQLKYTKDGKFRRFGFVGFKTPEDANNAI NYFNNNFINASKIQVELCAGLGDPQKSKAWSKYAADSSAFKKIHDPGEKK VNKKEQKKKKSDKNLNNGVEEVLEK------------------------- -------------HKDDPLFAEFLEAHGKGAKAVWSNNAVVSAEAVDIVE RNTSQPDKDSDYNTDDDGDAEEKEGLDSDDKSLAKANISDLDYLKTKIVE PLESSEASLDDEPSSGAKKTPKKPKEKEPKAPVTLFTVKVRGLPYKAKKK DVKQFFHPLKSKTIRFPRKMKGFVYIGFRTEKEMKQALLKNMSFL----- -------------------------------------------------- ------------------------------AGKRILVTQSVSKESSSKSK NEPTVSKWKDQEENLKHEESIAESGRIFVRNLSFTVTEEELTELLR---P LAELIMPVDRLSRKAKGFALVTFVIPENASTAYTELDGSVFHGRMLHLLP GKAKQSIEELLEQ-EGLTYQQKQKLKQKSQAASSHNWNTLFLGQNAVADL IAENYNTTK----------------EQVLDSSGKASVAVRLALGETQIVS QMREFLEESGVRLDAFNQAPKLRSKTTILIKNLPAKTSASEIRELFAKHG ELGRVVLPTAGVTAxxxxxxxxxxxxxxxxxxxxxxxxxxxxLEWAPSET FTAPFSKEKPLKKEAKVNSGLMIVEFLEPSEAKNAFTKLAYSKFKHLPLY LEWAPSETFTAPFSKEKPLKKEAKVNSGLMIVEFLEPSEAKNAFTKLAYS KFKHLPLYLEWAPSETFTAPFSKEKPLKKEVSKLNEQPAAGEKATETEAD EEATDDDEDPEPDTTLFIKNLNFETREDSVKE------------------ ----HFKKCGPIHYVTVALKKDPKKPGELLSMGYGFIQFKKKASADKALK TLQQSVLEGFSVELKRSNRTLQ---------------------------- -------------------------------------------------- ---TFGEIKAVRLPKKMVGTGPHRGFAFVDYLTKHDAKRAFKALCQSTHL YGRRLVLEWATSEEDVDEIRKRTAQHFLDEPPGVKNLRKSTIDPEDIEE- -xxxEEASTMLGSPGLACHPRRVQLTDQQLEAVTKEDLVKHWKELESYVD FLESNTSVQEGELTSIRELEERARQQHLESVHREKVLVRRLATKEQEMQE YVSQITELKASQAPGATALRSALLDPAVNLLLQRLRQELNSTRARLEETQ NELSAWKFTPDSNTGKRLMAKCRLLYQENEDLGRMISSGRLAKLEGELAL QKSFSEEVKKSQSELDEFLQELDEDVEGMQSTIYYLQQELRKSKDTVTAL QQENILLKTGGEGGNSSAAPDALAPTEDMSEEITASSEVLAPLEDLATSK VPAPSEVSAPSEVLAPSEELAPSELLAPSEIFVPSEVLAPRELSTPTQAP TGAKMWQKEMESEESQKKVLASPTPPEQYAGEDSSDSGELILKLEEEEEL EGEADSESAADKDTPLTGEAEPQLSIKHVEDPRVTLSYAEELRMSIKPAE EPQQANSKKEEVSRKRSFPKEEDSSGDDSDNVPLIKKVRRDSEISLHYED DDEAELITGEPAGSRLSDEQx >Tpa V------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -xxxxxx------------------------------------------- --QVTSEKIRDIFGEKGIVTDVQLKYTKDGKFRRFGFVGFKTPEDANNAI NYFNNNFINASRIQVELCAGLGDPQKPKAWSKYAPDSSAFKKIHNPEEKK INKKEQKKKKSDKNLNNGVKEVLEK------------------------- -------------HKDDPLFAEFMEAHGKGAKAVWSNNADVSAEAVEIVE RTTSQSDKDSDYNTDDDGDVEEKEGSDSNDKSLAKANISD---------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- xx------------------------------------------------ -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ---------------------