>Tge -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- --------------------------------MVHSAVVWPGAEPQAITI LYNSYMSIxFSTCTVLVCM------------------------------- ----------------------------------------DYVSAIRNKQ DVRELLLGTKSGDELVTARGSSKVLHQSSKTHTTRDTEDSQK-------- -------------------------------------------------- ----------------------------------VSAVEPDGKIITETRT TKEHEEVHDEQLPDDVDGVDEEETKKESSHRFQKTKNEELVEYLADGVKI GEEMRYQAENMEGDRQGNPEMGNWDSLSTRIRKMRRQGGRTTTRGIRSPG DGTMPVTPLDRKDALTKKPLDFDQEEETRKVETSKWLENHFGSDSRSSKD SLDDEEDSATPIAGGKTSFINVTMKSRPITGILNRTPSPAVNGNVVTPPK GYVANSSRVFVSSPESEEHLASAGSNGFFQGVSEWSERRNDTVLQTKEVK NTFSVPPPSVVTPHRPERVQVLPTGPNHVFRTKTEGVRFSSGSNNSLDRA TPPYNSRVVTEHLAGASPVSKTEHSMSYHKMNSGTNQEYDRRSPYQQNHT QDNFPIHARDTQPHWSARQRSPTRGAYQNSSSELSREFQEEESNHRLLGS Q-----KSFSPVKGYDEENDVYPASRGQSPPSRMRGA--EEEDSLPSRRG HLPTQRRNYVERFELEDGYRLAPRRWPDNATPTGDRSHDSEPEDPEPPPD YSPPPEPSPSPPPGNKKVYQRTRFAADIPPLQRHAATPSPPHKPPSTTSI IGQSFRRFVDRFRSSSSERRKNGKRRSGGGGKKKGESSRSPSPRQGSSTY QQYHVIDNNIPCV-EPGEEGESPHPVPPPRSARAGPQQQSLARNRAAHTH GRTYS--------------------------------QDEEQEMMDRGGI HHENRVVQKFYLGEDPFGGSIYGREREYDGVVPVKSRRHRHQPRGTAIHD EEVDVSS------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ------------------------------------------------Rx xxxxxxxxx----------xxxxxxxxxxxxxxxxxxxxxxxxxxxx--- -------------------------------------------------- -------------------------------------------------- -- >Tbi x------------------------xxxxxLTRRLGLEFLSSVLRASxxx xxAVHQTEIRxxxxPSSAVGLNTTSALANYATENRLDPLPCLPCFEAHRY QRSPSxxxxxxKCFLAPLSxxQLHTGRSCQPCAxxLxxxxxxxxxxxxxx xxxxxxxxTSISPSSxxxxxxxxxxxxxxxxxxxxxxxxxxx-------- -------------------------------------------------- ---------------------xxxxxxLxxxxxxxxxxxxLxxxxxxITI LPNSYxxI-xSTCTVLVCM------------------------------- ----------------------------------------DYVSAIRNKQ DVRELLLETKSGDELVTARGSSKVLHQSSKTHTTRDTEDSQKx------- -------------------------------------------------- -----------------xxxxxxxxxxxxxxxxxVSAVEPDGKIITETRT TKEHEEVHDEQLPDDVDGVDEEETKKESSHRFQKTKNEELVEYLADGVKI GEEMRYQAENMEGDRQGNPEMGNWDSLSTRIRKMRRQGGRTTTRGIRSPG DGTTPVTPLDRKDALTKKPLDFDQEEETRKVETSKWLENHFGSDSRSSKD SLDDEEDSATPIAGGKTSFINVTMKSRPITGILNRTPSPAVNGNVVTPPK GYVANSSRVFVSSPESEEHLASAGSNGFFQGVSEWSERRNDAVLQTKEVK NTFSVPPPSVVTPHRPERVQVLPTGPNHVFRTKTEGVRFSSGSNNSLDRA TPPYNSRVVTEHLAGASPVSKTEHSMSYHKMNSGTNQEYDRRSPYQQNHT QDNFPIYARDTQPHWSARQRSPTRGAYQNSSSELSREFQEEESNHRLLGS Q-----KSFSPVKGYDEENDVYPASRGQSPPSRMRGA--EEEDSLPSRRG HLPTQRRNYVERFELEDGYRLAPRRWPDNTTPTGDRSHDSEPEDPEPPPD YSPPPEPSPSPPPGNKKVYQRTRFAADIPPLQRHAATPSPPHKPPSTTSI IGQSFRRFVDRFRSSSSERRKNGKRRSGGGGKKKGESSRSPSPRQGSSTY QQYHVIDNNIPCV-EPGEEGESPHPVPPPRSARAGPQQQSLARNRAAHTH GRTYS--------------------------------QDEEQEMMDRGGI HHENRVVQKFYLGEDPFGGSIYGREREYDGVVPVKSRRHRHQPRGTAIHD EEVDVSS------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ------------------------------------------------xx xxxxxxxxx-------------------------------------xxxx xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx-- -------------------------------------------------- -- >Tpa xxxxxxxxxxxxxxxxxxxxxxxxxx------------------------ -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ----------------------------------VSAVEPDGKIITETRT TKEHEEVHDEQLPDDVDGVDEEETKKESSHRFQKTKNEELVEYLADGVKI GEEMRYQAENMEGDRQGNPEMGNWDSLSTRIRKMRRQGGRTTTRGIRSPG DGTTPVTPLDRKDALTKKPLDFDQEEETRKVETSKWLENHFGSDSRSSKD SLDDEEDSATPIAGGKTSFINVTMKSRPITGILNRTPSPAVNGNVVTPPK GYVANSSRVFVSSPESEEHLASAGSNGFFQGVSEWSERRNDTVLQTKEVK NTFSVPPPSVVTPHRPERVQVLPTGPNHVFRTKTEGVRFSSGSNNSLDRA TPPYNSRVVTEHLAGASPVSKTEHSMSYHKMNSGTNQDYDRRSPYQQNHT QDNFPIHARDTQPHWSARQRSPTRGAYQNSSSELSREFQEEESNHRLLGS QxxxSPKSFSPVKGYDEENDVYPVSRGQSPPSRMRGA--EEEDSLPSRRG HLPTQRRNYVERFELEDGYRLAPRRWPDNATPTGDRSHDSEPEDPEPPPD YSPPPEPSPSPPPGNKKVYQRTRFAADIPPLQRHAATPSPPHKPPSTTSI IGQSFRRFVDRFRSSSSERRKNGKRRSGGGGKKKGESSRSPSPRQGSSTY QQYHVIDNNIPCV-EPGEEGESPHPVPPPRSARAGPQQQSLARNRAAHTH GRTYS--------------------------------QDEEQEMMDRGGI HHENRVVQKFYLGEDPFGGSIYGREREYDGVVPVKSRRHRHQPRGTAIHD EEVDVSS------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ------------------------------------------------Rx xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx--- -------------------------------------------------- -------------------------------------------------- -- >Tte M------------------------------------------------- -------------------------------------------------- --------PR---------------------------------------- -----------------------------------------LDSHPDQAS VTDRYARGDSHSEPIKMxRNGELFVCLxxxxxxxxxxxxxxxxxxLQVLP TVxxxxxxxxxxxxxxxxxxxHELTGDLLAGYMVHSAVVWLGAEPQGITI LPNSYMNI-FSTCTVLVCM------------------------------- ----------------------------------------DYVSAIRNKQ DVRELLLETKSGDELVTARGSSKVLHQSSKTHTTRDTEDSQK-------- -------------------------------------------------- ----------------------------------VSAVEPDGKIITETRT TKEHEEVHDEQLPDDVDGVDEEETKKESSHRFQKTKNEELVEYLADGVKI GEEMRYQAENMEGDRQGNPEMGNWDSLSTRIRKMRRQGGRTTTRGIRSPG DGTTPVTPLDRKDALTKKPLDFDQEEETRKVETSKWLENHFGSDSRSSKD SLDDEEDSATPIAGGKTSFINVTMKSRPITGILNRTPSPAVNGNVVTPPK GYVANSSRVFVSSPESEEHLASAGSNGFFQGVSEWSERRNDAVLQTKEVK NTFSVPPPSVVTPHRPERVQVLPTGPNHVFRTKTEGVRFSSGSNNSLDRA TPPYNSRVVTEHLAGASPVSKTEHSMSYHKMNSGTNQEYDRRSPYQQNHT QDNFPIYARDTQPHWSARQRSPTRGAYQNSSSELSREFQEEESNHRLLGS Q-----KSFSPVKGYNEENDVYPASRGQSPPSRMRGA--EEEDSLPSRRG HLPTQRRNYVERFELEDGYRLAPRRWPDNATPTGDRSHDSEPEDPEPPPD YSPPPEPSPSPPPGNKKVYQRTRFAADIPPLQRHAATPSPPHKPPSTTSI IGQSFRRFVDRFRSSSSERRKNGKRRSGGGGKKKGESSRSPSPRQGSSTY QQYHVIDNNIPCV-EPGEEGESPHPVPPPRSARAGPQQQSLARNRAAHTH GRTYS--------------------------------QDEEQEMMDRGGI HHENRVVQKFYLGEDPFGGSIYGREREYDGVVPVKSRRHRHQPRGTAIHD EEVDVS-------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -----------------------------------------------xxx xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx xx >Tcm -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ----VPPPSVVTPHRPERVQVLPTGPNHVFRTKTEGVRFSSGSNNSLERA TPPYNGRVVTERLASASPVGKTEHSVSHHKTNSGTNQDYDRRSPYQQNHT QDNFPIHARDPHPHWSARQRSPTRAAYQNSSSELSREFQEEESNHRLLGS Q-----KSFSPVKGYDEENDVYPASRGQSPPSRTRGAxxEEEESLPSRRG HLPTQKRNYVERFELEDGYRLTPRRWPDNATPTGERSHDSEPEDPEPPPD YSPPPEPSPSPPSGNKKVYQRTRFAADIPPLQRHAATPSPPHKPPSTTSI -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -- >Tms -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ------------------xxxLxxxxxxxxxxxxxxxxxxxxxxxxxxxx xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxDYVTAIRNKQ DVRELLLGTKSGDELVTARGSSKVLHQSSKTHTTRDTEDSQK-------- ------------------------xxxxxxxxxxxxxxxxxxxxxxxxxx xxxxxxxxxxxxxxxxxx----------------VSAVEPDGKIITETRT TKEHEEVHDEQLPDDVDGVDEEETKKESSHHFQKTKNEELVEYLADGVKI GEEMRYQAENTEGDRQGNPEMGNWDSLSTRIRKMRRQGGRTTTRGIRSPG DGTTPVTPLDRKDALTKKPLDFDQEEETRKVETSKWLENHFGSDSRSSKD SLDDEEDSATPIAGGKTSFINVTMKSRPITGILNRTPSPAVNGNIVTPPK GYVTNSSRVFVSSPESEEHLASAGSNGFFQGVSEWSERRNDAVLQTKEVK NTFSVPPPSVVTPHRPERVQVLPTGPNHVFRTKTEGVRFSSGSNNSLERV TPPYNSRVVTEHLASASPVSKTEHSMSYHKMDSGTNQDYDRRSPYQQNHT QDNFPIYARDSQPHWSARQRSPTRGVYQNSSSELSREFQEEESNHRLLGS Q-----KSL-PVKGYDEENNVYPASRGQSSPSRMRGA--TEEESLPSRRG HLPTQKRNYVERFELEDGYRLTPRRWPDNATPTGEHSHDSEPEDPEPPPD YSPPPEPSPSPPTGNKKVYQRTRFAADIPPLQRHAATPSPPHKPPSTTSI IGQSFRRFVDRFRSSSSERRKNGKRRSGGGGKKKGESSRSPSPRQGSSTY QQYHVIDNNIPCL-EPGEGGESSHPVPPPRSARAGPQQQSLARNRDAHTH GRTYSxERVLTYCDRLSRRDRQTDECRERAYKRELPFQDEEQEMMDRGGI HHENRVVQKFYLGEDPFGGSIYGREREYDGVVPVKSRRHRHPPRGTAIHD EEVDVSSxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx xxxxxQHxxAAPPLGNxxxHSSxxxxxxxxNHVTPPSGPAKxxxxxxxxx xxxxxxxVHASSEPPLPSSVYKSNPQLHRLDESPPPLKSPGILASISRSQ RDLTREEIHDNRHSRVIGNGTPQGTKKRMFMxxxxxxxxxxxxxxxGDxx IVDxxxESRSPSGRLITSTPLKNSRVxxxxNSFRSSSTNANPSEDPYKRS SPYRFSKINGVDGLSSPVGNHxxxxGSSLSHSSSFRDNNGTTTSVVRKGS PGKNDYSETVRITSKSDDPIRPSVTNTIQSFTKKTIPTKGGKSxxxxxxx xxxxxxxxxxRFRGExEHINGMRYLDSPSSKYTMGNGGGGVVIExRPTxx -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -- >Tce x------------------------xxxxx-------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ----------------------------------------DYVTAIRNKQ DVRELLLGAKSGDELVTARGSSKVLHQSSKTHTTRDTEDSQKExxxxxxx xxxxxxxxxxxxxxxxxxxxxxxxx------------------------- -----------------------------------SAVEPDGKIITETRT TKEHEEVHDEQLPDDVDGVDEEETKKESSHHFQKTKNEELVEYLADGVKI GEEMRYQAENTEGDRQGNPEMGNWDSLSTRIRKMRRQGGRTTTRGIRSPG DGTTPVTPLDRKDALTKKPLDFDQEEETRKVETSKWLENHFGSDSRSSKD SLDDEEDSATPIAGGKTSFINVTMKSRPITGILNRTPSPAVNGNVVTPPK GYVTNSSRVFVSSPESEEHLASAGSNGFFQGVSEWSERRNDAVLQTKEVK NTFSVPPPSVVTPHRPERVQVLPTGPNHVFRTKTEGVRFSSGSNNSLERV TPPYNSRVVTEHLASASPVSKTEHSMSYHKMDSGTNQDYDKRSPYQQNHT QDNFPIYARDSQPHWSARQRSPTRGVYQNSSSELSREFQEEESNHRLLGS Q-----KSL-PVKGYDEENNVYPASRGQSPPSRMRGA--AEEESLPSRRG HLPTQKRNYVERFELEDGYRLTPRRWPDNATPTGEHSHDSEPEDPEPPPD YSPPPEPSPSPPTGNKKVYQRTRFAADIPPLQRHAATPSPPHKPPSTTSI IGQSFRRFVDRFRSSSSERRKNGKRRSGGGGKKKGESSRSPSPRQGSSTY QQYHVIDNNIPCL-EPGEGGESSQPVPPPRSARAGPQQQSLARNRDAHTH GRTYSxKR---------QTDRQTDECRERAYKRELTFQDEEQEMMDRGGI HHENRVVQKFYLGEDPFGGSIYGREREYDGVVPVKSRRHRHPSRGTAIHD EEVDVSSxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx xxxxxQHxxAAPPLGNxxxHSSxxxxxxxxNHVTPPSGPAKxxxxxxxxx xxxxxxxVHASSEPPLPSSVYKSNPQLHRLDESPPPLKSPGILASISRSQ RDLTREEIHDNRHSRVIGNGTPQGTKKRMFMxxxxxxxxxxxxxxxGDxx xxxxxxxxxxxxxxLITSTPLKNSRVxxxxNSFRSSSTNANPSEDPYKRS SPYRFSKINGVDGLSSPVGNHxxxxGSSLSHSSSFRDNNGTTTSVVRKGS PGKNDYSETVRITSKSDxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx xxxxxxxxxxRFRGExxHINGMRYLDSPSSKYTMGNGxxxVVIExRPTxx -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -- >Tsi -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------QRHAATPSPPHKPPSTTSI IGQSFRRFVDRFRSSSSERRKNGKRRS--GGKKKGGSSRSPSPCQGSSTY QQYHVIDNNIPCAEEPGEEGESPHPVPPPRSARAGPPQQSLVRNRAAHTH VRTYS--------------------------------QDEEQEMMDRGGV HHENRVVQRFYLGEDPFGGSIYGREREYDGVVPTKSRRHRHQPRGTATHD EVADVS-------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -----------------------------------------------xxx xxxxx--------------------------------------------- -x