>Tge -------------------------------------------------- ---------------------------------------xxKSQVEMQRR LEKDRQRSEHSGISxxVTTETPVNADGEQDGEEETTEKRIVIQILEDGTx YAPDHKMTLQMEGLEKPRRKRGRPPKRPPDPEEDRAKELEEPLENPPEEE MEEDADGRKRRRIKxPQR----------------------------FKEA VQxKELDRIFKEEGLINEDEDEEGVEEEEVQEKTPPLEVIxxxA------ ---------EVIGHLETQEGQDLGELVIVNRGRKRGRPRGGKRRKVRFEC EICGRGFLHKGRYKIHKTYHKGVKFECSSCNKRFVNRELFESHQKTTGHI GE---------GIIEGLADGGDGGEMPGCRVKCWQCDKTFQTKQSFEVHQ KAIHEGVKPFVCEVCDRTFAYQNSLKCHMLASHCE--------------- -------------------------------------------------- -------------------------------------------------- ---------------------DAKGLDKDKGYPCDMCDKKFNHPSSVVYH KEAEHNNGRVFVCNKCGKGFRHRQLLQRHQLVHSEDR------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- --xxVCKSCGASFKTKANLLNHQPTHTGEKKYFCELCGQQFAHKTSLTLH YRWH---------------------------------------------- ---x-------xxxxxxxxxxxxxxxx-----------------xFKLHV KRHTGERPWKCDFCGKSFLHKDTWKCHTRRHKGERPFQCHYCARGFTEQW ALKKHLRLHTGE-------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- --------------KPYTCNTCGKCFADCSNLAKHKKFLV---------- -------------------------------------------------- -----------------FLSTNRCR------------------------- ---------------------xxxxxxxxxxxxxxxMRPCxxxVHKGSCE NESTAPGDSLVDRTTVWNIIQSHLAKDVSEQDGADSQGEDAGQQIIYVTY QDPDDPEGKTLH-------------------------------------- -------------------------------------------------- -------------------------------------------------I VDSQQNP-------------------------QHSELEQSQEQHQVALRE TEEVGELEGSKDSLGSLPHSLQVMDEEGNPIHFTMQDGRELQITTTDGQS LHVTTLDGQTIPLQLTTPDGQPLTAGGPEVRVHPSNDNLMMGQPSDDLMI QESHTNPNGMLKSVKGSEGPAGEPLTEGEQAIEFTTPDGQKVRLVTSYGV DPITEYLSTNT >Tpa xxxxxxxx------------------------------------------ -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------VHKGSCE NESTAPGDSLVDRTTVWNIIQSHLAKDVSEQDGADSQGEDAGQQIIYVTY QDPDDPEGKTLH-------------------------------------- -------------------------------------------------- -------------------------------------------------I VDSQQNP-------------------------QHSELEQSQEQHQVALRE TEEVGELEGSKDSLGSLPHSLQVMDEEGNPIHFTMQDGRELQITTTDGQS LHVTTLDGQTIPLQLTTPDGQPLTAGGPEVRVHPSNDNLMMGQPSDDLII QESHTNPNGMLKSVK----------------------------------- ----------x >Tsi -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- --------xxxx--------------------------------xFKLHV KRHTGERPWKCDFCGKSFLHKDTWKCHTRRHKGERPFQCHYCARGFTEQW ALKKHLRLHTGE-------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- --------------KPYTCNTCGKCFADCSNLAKHKK------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------VHKGSCE NESTAPGDSLVDRTTVWNIIQSHLAKDVSEQDGADSQGEDAGQQIIYVTY QDPDDPEGKTLH-------------------------------------- -------------------------------------------------- -------------------------------------------------I VDSQQNP-------------------------QHSELEQSQEQRQVALGE TEEVGELEESKGSLGPLPHSLQVMDEEGNPIHFTMQDGRELQITTTDGQS LHVTTLDGQTIPLQLTTPDGQPLTAGGPEVRVHPSDDNLMMGQPSDDLIV QEPHTHPNGMLKSVKGSERLSGEPLAEGEQAIEFTTPDGQKVRLVTSYGV DPITEYLSTNT >Tcm x------xxxxYDSTICRLCGEENDSGVFLYTNEELEPDLSVLVNKYLPC KIQDDGKLPRTICPGCNIQLQATVQFFDLLVEGQKKIREMWKNQVELNRR LEKERQRSEHTGISxxVTTETPVNADGEQDGEEETTEKRIVIQILEDGSx YAPDHKMTLQMEGLEKPRRKRGRPPKRPPDPEEDKPKELEEPLENQPEEE MEEDADGRKRRRIKxPQRLALFTITLGDGHYLEVKGSGI------VFKEA VQxKELDRIFKEEGLINEDEEEEGVEEEEVQEKTPPLEVIxxxA------ ---------EVIGHLETQEGQDLGELVIVNRGRKRGRPRGGKRRKVRFEC EICGRGFLHKGRYKIHKTYHKGVKFECSSCNKRFVNRELFETHQKTTGHI GE---------GIIEGLADGGDGGEMPGCRVKCWQCDKTFQTKQSFEVHQ KAIHEGAKPFVCEVCDRTFAYQNSLKCHMLASHCE--------------- -------------------------------------------------- -------------------------------------------------- ---------------------DTKGLDKDKGYPCDMCDKKFNHPSSVIYH KEAEHNNGRVFVCNKCGKGFRHRQLLQRHQLVHSEDRxxTRRTGExxxHx Axxxxxxxxxxxxxxxxxxxxxx--------------------------- --------------GEYSLHTASWYxxxxxEYSxxTASWYTRRTGxxxxx xxxxxxxxxxxxxxxxxxxxxxxxxGYSLHTAxxxxxxxxxxxxxxAxxY TRxxGxYxxxxxxxxxxxxxxxxxHxxxxxxxxxxxxxxxxxxxxxxxxx xxxxxxx------------------------------------------- xxxxVCKSCGASFKTKANLLNHQPTHTGEKKYFCELCGQQFAHKTSLTLH YRWH---------------------------------------------- ---xGKxx-------------------------------------FKLHV KRHTGERPWKCDFCGKSFLHKDTWKCHTRRHKGERPFQCHYCARGFTEQW ALKKHLRLHTGE-------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- --------------KPYTCNTCGKCFADCSNLAKHKK------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------VHKGSCE NESTAPGDSLVDRTTVWNIIQSHLAKDVSEQDGADSQGEDAGQQIIYVTY QDPDDPEGKTLH-------------------------------------- -------------------------------------------------- -------------------------------------------------I VDSQQNP-------------------------QHSELEQSQEQRQVALGE TEEVGELEESKGSLGSLPHSxxVMDEEGNPIHFTMQDGRELQITTTDGQS LHVTTLDGQTIPLQLTTPDGQPLTAGGPEVRVHPSDDNLMMGQPSDDLIV QEPHTHPNGMLKSVKGSERLSGEPLAEGEQAIEFTTPDGQKVRLVTSYGV DPITEYLSTNT >Tps x------xxxxYDSTICRLCGEENDSGVFLYTNEELEPDLSVLVNKYLPC KIQDDGKLPRTICPGCNIQLQATVQFFDLLVEGQKKIREMWKNQVELNRR LEKERQRSEHTGISxxVTTETPVNADGEQDGEEETTEKRIVIQILEDGSx YAPDHKMTLQMEGLEKPRRKRGRPPKRPPDPEEDRPKELEEPLENQPEEE MEEDADGRKRRRIKxPQR----------------------------FKEA VQxKELDRIFKEEGLINEDEEEEGVEEEEVQEKTPPLEVIxxxGWxxxxx xxxxxxxxxKVIGHLETQEGQDLGELVIVNRGRKRGRPRGGKRRKVRFEC EICGRGFLHKGRYKIHKTYHKGVKFECSSCNKRFVNRELFESHQKTTGHV GE---------GIIEGLADGGDGGEMPGCRVKCWQCDKTFQTKQSFEVHQ KAIHEGAKPFVCEVCDRTFAYQNSLKCHMLASHCEVELxEVNPxLRGGxx xxxxEKTTPxxxDRDSNLxx------------------------------ -------------------xxxxxxxxxxTRVSQLRHRGGGPLLLTPSTH TIESFPLIxDSNQTWYYLFVQDTKGLDKDKGYPCDMCDKKFNHPSSVIYH KEAEHNNGRVFVCNKCGKGFRHRQLLQRHQLVHSEDR------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- --xxVCKSCGASFKTKANLLNHQPTHTGEKKYFCELCGQQFAHKTSLTLH YRWHxxxxxxxxxxxxxIxxxxxxxxxxxYLFKAVSCELxxxxxxxxxxx xxxx-----------------------------------------FKLHV KRHTGERPWKCDFCGKSFLHKDTWKCHTRRHKGERPFQCHYCARGFTEQW ALKKHLRLHTGE-------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- --------------KPYTCNTCGKCFADCSNLAKHKK------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------VHKGSCE NESTAPGDSLVDRTTVWNIIQSHLAKDVSEQDGADSQGEDAGQQIIYVTY QDPDDPEGKTLH-------------------------------------- -------------------------------------------------- -------------------------------------------------I VDSQQNP-------------------------QHSELEQSQEQRQVALAE TEEVGELEESKGSLGSLPHSLQVMDEEGNPIHFTMQDGRELQITTTDGQS LHVTTLDGQTIPLQLTTPDGQPLTAGGPEVRVHPSDDNLMMGQPSDDLIV QEPHTHPNGMLKSVKGSERLSGEPLAEGEQAIEFTTPDGQKVRLVTSYGV DPITEYLSTNT >Tms x------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ---------xxxxxxxxxxEQDTKGLDKDKGYPCDLCDKKFNHPSSVVYH KEAEHNNGRVFVCNKCGKGFRHRQLLQRHQLVHSEDR------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ------xxTLFIPPAGxxxGLxxxxxxxPxxxxxxxxxxxxxxxxxxxxx x------SCGASFKTKANLLNHQPTHTGEKKYFCELCGQQFAHKTSLTLH YRWH---------------------------------------------- ---xxxxx-------------------------------------FKLHV KRHTGERPWKCDFCGKSFLHKDTWKCHTRRHKGERPFQCHYCARGFTEQW ALKKHLRLHTGE-------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- --------------KPYTCNTCGKCFADCSNLAKHKK------------- -------------------------------------------------- ------------------------KQNLGTPDR--------------DSx xxxxxxxxxxxxExxxFDHAxxx--------------------VHRGSCE NESTAPGDSLVDRTTVWNIIQSHLAKDVSEQDGADSQGEDAGQQIIYVTY QDPDDPEGKTLH-------------------------------------- -------------------------------------------------- -------------------------------------------------I VDSQQNP-------------------------QHSELEQSQEQHQVALRE TEEVGELERSKDPLGSLPHSLQVMDEEGNPIHFTMQDGRELQITTTDGQS LHVTTLDGQTIPLQLTTPDGQPLTAGGPEVRVHPSNDNLMMGQPSDDLII QESHTHPNGMLKSVKGT-----EPLAEGEQAIEFTTPDGQKVRLVTSYGV DPITEYLSTNT >Tce x------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- --------------------------------------xxxxxxxxFKEA VQ-----------------------------------------A------ ---------EVIGHLETQEGQDLGELVIVNRGRKRGRPRGGKRRKVRFEC EICGRGFLHKGRYKIHKTYHKGVKFECSSCNKRFVNRELFESHQKTTGHI GE---------GIIEGLADGGDGGEMPGCRVKCWQCDKTFQTKQSFEVHQ KAIHEGAKPFVCEVCDRTFAYQNSLKCHMLASHCR--------------- -------------------LxxxxxxxxVSPNxxxxxxSSVPSFSFHSCQ SLPTPPSxTCLQSPPxxxxx------------------------------ ---------------------DTKGLDKDKGYPCDLCDKKFNHPSSVVYH KEAEHNNGRVFVCNKCGKGFRHRQLLQRHQLVHSEDR------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- --xxVCKSCGASFKTKANLLNHQPTHTGEKKYFCELCGQQFAHKTSLTLH YRW----------------------------------------------- -------------------------------------------------- -------------------------------------------------- --------HTGE-------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- --------------KPYTCNTCGKCFADCSNLAKHKK------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------VHRGSCE NESTAPGDSLVDRTTVWNIIQSHLAKDVSEQDGADSQGEDAGQQIIYVTY QDPDDPEGKTLH-------------------------------------- -------------------------------------------------- -------------------------------------------------I VDSQQNP-------------------------QHSELEQSQEQHQVALGE TEEVGELERSKDPLGSLPHS--------------------xxITTTDGQS LHVTTLDGQTIPLQLTTPDGQPLTAGGPEVRVHPSNDNLMMGQPSDDLII QESHTHPNGMLKSVKGT-----EPLAEGEQAIEFTTPDGQKVRLVTSYGV DPITEYLSTNx >Tdi x------------------------------------------------- ---------------------------------------------ELNRR LEKERQRSEHTGISxxVTTETPVNADGEQDGEEETTEKRIVIQILEDGSx YAPDHKMTLQMEGLEKPRRKRGRPPKRPPDPEEDRPKELEEPLENQPEEE MEEDADGRKRRRIKxPQR----------------------------FKEA VQxKELDRIFKEEGLINEDEEEEGVEEEEVQEKTPPLEVIxxxGWxxxxx xxxxxxxxxKVIGHLETQEGQDLGELVIVNRGRKRGRPRGGKRRKVRFEC EICGRGFLHKGRYKIHKTYHKGVKFECSSCNKRFVNRELFESHQKTTGHV GEVQLATVLFSGIIEGLADGGDGGEMPGCRVKCWQCDKTFQTKQSFEVHQ KAIHEGAKPFVCEVCDRTFAYQNSLKCHMLASHCEVELxEVNPxLRGGxx xxxxEKTTPxxxDRDSNLxx------------------------------ -------------------xxxxxxxxxxTRVSQLRHRGGGPLLLTPSTH TIESFPLIxDSNQTWYxxFVQDTKGLDKDKGYPCDMCDKKFNHPSSVIYH KEAEHNNGRVFVCNKCGKGFRHRQLLQRHQLVHSEDRxxTRRxxxxxxH- --------------TASWYTRRTxxRIExxxIIxxxxxxDxxxxSKNRxx WxxxxxxxxxxxxxG----------------------------------- -------------------------------------------------- -------------------------------------------------- ----xxx---------------------------------------xxxx x------SCGASFKTKANLLNHQPTHTGEKKYFCELCGQQFAHKTSLTLH YRWH---------------------------------------------- ---xGxPR----------------VSxSLEKKMIPGHRNLIWxxxFKLHV KRHTGERPWKCDFCGKSFLHKDTWKCHTRRHKGERPFQCHYCARGFTEQW ALKKHLRLHTGQTWDHIKNHILTHSVHxxxxxxxxxxxxxxxxxxxxxxx THSxxxxxxxxxxxxxxxxxxxxxxxxxxxxxHKPLxxxxxxxxxxxxxx xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx xxxxxxxxxxxxxxxxxxxxVCGxxxxxxxxxxxx---xxxxxxxxxxxx DVxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx xxxxxxxxxxxxxxxxGILK----AHxxxxxxxxxxxxxVCxxxxxxxxx xxxxxx-------------------------------------------- -------------------------------------------------- ----------xxxxxxxxxCSLCGKCFKAKSILKAHxxxxxxxxxHKCDF CGKGFKxxxxxxxHLVSHGEHRPHKCDVCGKCxxxxxxxxxxxxxxxxxx xxxxxxxxxxxxxNSNLKSHxxxxxxxxPYICSLCGKCxxxxxxxxxxxx xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx-------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ----------M