>Tge xxxxxxx------------------------------------------- --------------------------------LYPEDPLPKTVCIDCCAK LNQYFDFFESSSRAQLSLQLMFDPKENKNEMKKELDQEPTEQATARVEGE DSPSGETGNTVSAEERLFGVRKx--------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ------------------------LVVPRQGLVxxxxxxxxx-------x xxxxxxxxxxxxxxxxxxxxFPxx-----------xxxVPPRQGLVVPRQ GLL-----------VPRx------------------------xxVP---- -----------------------------------LKTRSSPLKxxxxxL Kxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx------ ----KLNSSASSRRKRRVPMKRAPPTRKERVTRQRADKKERKESEEEPLN ------AVKEEVKEEPMPASKADFEDNFLFGDDVGAGIEDSSEEDA-EEE EEE-EEDQSFDPKKKQVSGAANERKKKRKKGL------------------ ----------------------xxxxxxxxxxxxxxxxxxxxxxxxxxxx xxxxxxxxxxxxxxxxxxxxxxxxxVKHSQLPNFKCVQCAKVYTRYRSFA RHVKLHRNPKKF---------------RCEECGKCFSQKTVLQSHSTVHT DARPHVCPQCGKAFKQFSSLYLHSKCHLPDQTKPKFPCGVCQKEFATKHT LETHRKIHTGERNFICDVCGKSFIAKGSLDYHILTHSGEKPHHCQVCGK- ----------------------------GFKTARLLGKHATLHTGIKPHQ CDVCGKQFRERGALREHNRIHTGAMPYTCEFCGKNFRFKGILTVHRRQHT GERPYGCTD--------------------------SPTRSANTRTYHPPA ASIAANTAPVVYSNLTGGAGDNSNSSTLTQNSGMYSLQNNHSNLTSAVAK MAAANLYNQHLASNKMAAVFQHGAGANHASKMANVFHQQDSQDSLDRSNH SSTGGNVASNPLMGSYHVPSYVPAGLPMGSMGYYIPPIHHSDPSMDMLQH RMANNQ >Tms M-----------------------------------------xxxx---- --------------------------------LYPEDPLPKAVCIDCCAK LNQYFDFFESSSRAQLSLQLMFDPKDNKNEMKKELDQEQTDQATTRIEGE DSPS---------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ----ELNSSASSRRKRRVPMKRAPPTRKERVTRQRADKKERKECEEEPLN ------VVKEEVKEEPLPASKADFEDNFLFGDDVGAGIEDSSEEDAxEEE EEE-EEDRSFDPKKKQVSGATNERKKKQKKGLGKICSSKLPRTKSVLEGY PWQCTDCTSILPTLQELRTHHQ---------------------------- -------------------------VKHSQLPNFKCVQCAKVYTRYRSFA RHVKLHRNPKKF---------------RCEECGKCFSQKTVLQSHSTVHT DARPHVCPQCGKAFKQFSSLYLHSKCHLPDQTKPKFPCGVCQKE------ -------------------------------------------------- -----------------------------FKTARLLGKHATLHTGIKPHQ CDVCGKQFRERGALREHNRIHTGAMPYTCEFCGKNFRFKGILTVHRRQHT GERPYGCTDCRREFTNWANYNKHMKRRHRNDNDPSAPTRSANTRTYHPPA ASIAANAAPVVYSNLTGGAGDNSNSSTLTQNSGMYSLQNNHSNLTSAVAK MAAANLYNQHLASNKMAAVFQHGAGANHTSKMANVFHQQDSQDSLDRSNH SSTGGNVASNPLMGSYHVPSYVPAGLPMGSMGYYIPPIHHSDPSMDMLQH RMANNQ >Tce M--------------------------------------------x---- --------------------------------LYPEDPLPKAVCIDCCAK LNQYFDFFESSSRAQLSLQLMFDPKDNKNEMKKELDQEQTDQATTRIEGE DSPSGExGNTVSAE------------------------------------ -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -----------------xxxxxxxxxxxxxxxxxxxxxxxxxx------- -------------xxxxxxxxxxxxxxxxxxxxxxx-------------- -------------------------------------------xxxxxxx xxxxKLNSSASSRRKRRVPMKRAPPTRKERVTRQRADKKERKECEEEPLN ------VVKEEVKEEPLPASKTDFEDNFLFGDDVGAGIEDSSEEDA-EEE EEE-EEDRSFDPKKKQVSGATNERKKKRKKGLGKICSSKLPRTKSVLEGY PWQCTDCTSILPTLQELRTHHQ---------------------------- -------------------------VKHSQLPNFKCVQCAKVYTRYRSFA RHVKLHRNPKKF---------------RCEECGKCFSQKTVLQSHSTVHT DARPHVCPQCGKAFKQFSSLYLHSKCHLPDQTKPKFPCGVCQKE------ -------------------------------------------------- -----------------------------FKTARLLGKHATLHTGIKPHQ CDVCGKQFRERGALREHNRIHTGAMPYTCEFCGKNFRFKGILTVHRRQHT GERPYGCTDCRREFTNWANYNKHMKRRHRNDNDPSAPTRSANTRTYHPPA ASIAANAAPVVYSNLTGGAGDNSNSSTLTQNSGMYSLQNNHSNLTSAVAK MAAANLYNQHLASNKMAAVFQHGAGANHTSKMANVFHQQDSQDSLDRSNH SSTGGNVASNPLMGSYHVPSYVPAGLPMGSMGYYIPPIHHSDPSMDMLQH RMANNQ >Tsi MMTC---GxxxxxxxxxxxxxQxxFxxxxxxxKIFPPLIxxxxxxx---- --------------------------------LYPEDPLPKTVCIDCCAK LNQYFDFFESSSRAQLSLQLMFDPKDNKNEMKKELDQEPTEQATTRIEGE DSPSGETGNTVSAEEGLFGVWK---------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -----------------------xLxVPRQxxVxxxxxxxxx-------R xxx---------------xx---x-----------xxxxxxxxxxxxxxx xxx-----------VPxx-------------------------------- -------------------------------------------------- -------------------------------------------------- ----ELNSSASSRRKRRVPMKRAPPARKERVTRQRADKKDRKECEEEPVN ------VVKEEVKEEPLPAAKPDFEDTFLFGDDVGAGIEDSSEEEA-EEE EEE-EEDRSFDPKKKQVSGATNDRKKKRKKGLGKMCSSKLPRTKSVLEGY PWQCTDCTSILPTLQELRTHHQ---------------------------- -------------------------VKHSQLPNFKCVQCAKVYTRYRSFA RHVKLHRNPKKF---------------RCEECGKCFSQKTVLQSHSTVHT DARPHVCPQCGKAFKQFSSLYLHSKCHLPDQTKPKFPCGVCQKE------ -------------------------------------------------- -----------------------------FKTARLLGKHATLHTGIKPHQ CDVCGKQFRERGALREHNRIHTGAMPYTCEFCGKNFRFKGILTVHRRQHT GERPYGCTDCRREFTNWANYNKHMKRRHRNDNDPSAPTRSANTRTYHPPA ASIVANTAPVVYSNLTGGAGDNSNSSTLTQNSGMYSLQNNHSNLTSAVAK MAAANLYNQHLASNKMAAVFQHGAGANHTSKMANVFHQQDSQDSLDRSNH SSTGGNVASNPLMGSYHVPSYVPAGLPMGSMGYYIPPIHHSDPSMDMLQH RMANNQ >Tdi M-----------------------------------------xxxx---- --------------------------------LYPEDPLPKTVCIDCCAK LNQYFDFFESSSRAQLSLQLMFDPKDNKNEMKKELDQEPTEQAATRIEGE DSPSGETGNTVSAEEGLFGVWK---------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -----------------------xLxVPRQxxVxxxxxxxxx-------R Qxx---------------xx---xxxxxxxxxxxxx-------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ----ELNSSASSRRKRRVPMKRAPPARKERVTRQRADKKDRKECEEEPVN xVNVVKVVKEEVKEEPLPAAKPDFEDTFLFGDDVGAGIEDSSEEEA---E EEE-EEDRSFDPKKKQVSGATNDRKKKRKKGLGKMCSSKLPRTKSVLEGY PWQCTDCTSILPTLQELRTHHQ---------------------------- -------------------------VKHSQLPNFKCVQCAKVYTRYRSFA RHVKLHRNPKKF---------------RCEECGKCFSQKTVLQSHSTVHT DARPHVCPQCGKAFKQFSSLYLHSKCHLPDQTKPKFPCGVCQKE------ -------------------------------------------------- -----------------------------FKTARLLGKHATLHTGIKPHQ CDVCGKQFRERGALREHNRIHTGAMPYTCEFCGKNFRFKGILTVHRRQHT GERPYGCTDCRREFTNWANYNKHMKRRHRNDNDPSAPTRSANTRTYHPPA ASIAANTAPVVYSNLTGGAGDNSNSSTLTQNSGMYSLQNNHSNLTSAVAK MAAANLYNQHLASNKMAAVFQHGAGANHTSKMANVFHQQDSQDSLDRSNH SSTGGNVASNPLMGSYHVPSYVPAGLPMGSMGYYIPPIHHSDPSMDMLQH RMANNQ >Tbi -------x----------------------------------xxxxxxxx xxxxxxxxxKIxxExxxxxxLATKIxxxxxxxLYPEDPLPKTVCIDCCAK LNQYFDFFESSSRAQLSLQLMFDPKENKNEMKKELDQEPTEQATARVEGE DSPS---------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -----------------------xxxVPRQGLVxxxxxxxxxxxxxxx-- ----------------------------------------xxxxxxxxxx xxx-----------VPxx-------------------------------- -------------------------------------------------- -------------------------------------------------- ----ELNSSASSRRKRRVPMKRAPPTRKERATRQRADKKERKECEEEPLN ------VVKEEVKEEPTPASKADFEDNFLFGDDVGAGIEDSSEEDA-EEE EEE-EEDQSFDPKKKQVSGAANERKKKRKKGLGKMCSSKLPRTKSVLEGY PWQCTDCTSILPTLQELRTHHQ---------------------------- -------------------------VKHSQLPNFKCVQCAKVYTRYRSFA RHVKLHRNPKKF---------------RCEECGKCFSQKTVLQSHSTVHT DARPHVCPQCGKAFKQFSSLYLHSKCHLPDQTKPKFPCGVCQKEFATKHT LETHRKIHTGERNFICDVCGKSFIAKGSLDYHILTHSGEKPHHCPVCGK- ----------------------------GFKTARLLGKHATLHTGIKPHQ CDVCGKQFRERGALREHNRIHTGAMPYTCEFCGKNFRFKGILTVHRRQHT GERPYGCTDCRREFTNWANYNKHMKRRHRNDNDPSAPTRSANTRTYHPPA ASIAANTAPVVYSNLTGGAGDNSNSSTLTQNSGMYSLQNNHSNLTSAVAK MAAANLYNQHLASNKMAAVFQHGAGANHASKMANVFHQQDSQDSLDRSNH SSTGGNVASNPLMGSYHVPSYVPAGLPMGSMGYYIPPIHHSDPSMDMLQH RMANNQ >Tte Mxxxxxx------------------------------------------- --------------------------------LYPEDPLPKTVCIDCCAK LNQYFDFFESSSRAQLSLQLMFDPKENKNEMKKELDQEPTEQATARVEGE DSPS---------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -----------------------xxxVPRQGLVxxxxGLVVxxxxxxx-- ----------------------------------------xxxxxxxxxx xxx-----------xxxx-------------------------------- -------------------------------------------------- -------------------------------------------------- ----ELNSSASSRRKRRVPMKRAPPTRKERATRQRADKKERKECEEEPLN ------VVKEEVKEEPTPASKADFEDNFLFGDDVGAGIEDSSEEDA-EEE EEE-EEDQSFDPKKKQVSGAANERKKKRKKGLGKMCSSKLPRTKSVLEGY PWQCTDCTSILPTLQELRTHHQ---------------------------- -------------------------VKHSQLPNFKCVQCAKVYTRYRSFA RHVKLHRNPKKF---------------RCEECGKCFSQKTVLQSHSTVHT DARPHVCPQCGKAFKQFSSLYLHSKCHLPDQTKPKFPCGVCQKEFATKHT LETHRKIHTGERNFICDVCGKSFIAKGSLDYHILTHSGEKPHHCPVCGK- ----------------------------GFKTARLLGKHATLHTGIKPHQ CDVCGKQFRERGALREHNRIHTGAMPYTCEFCGKNFRFKGILTVHRRQHT GERPYGCTDCRREFTNWANYNKHMKRRHRNDNDPSAPTRSANTRTYHPPA ASIAANTAPVVYSNLTGGAGDNSNSSTLTQNSGMYSLQNNHSNLTSAVAK MAAANLYNQHLASNKMAAVFQHGAGANHASKMANVFHQQDSQDSLDRSNH SSTGGNVASNPLMGSYHVPSYVPAGLPMGSMGYYIPPIHHSDPSMDMLQH RMANNQ >Tpa Mxxxxxx------------------------------------------- --------------------------------LYPEDPLPKTVCIDCCAK LNQYFDFFESSSRAQLSLQLMFDPKENKNEMKKELDQEPTEQATARVEGE DSPSGETGNTVSAEERLFGVRKxxxxxxxxxxxxxxxxxxxxxxxxxxxx xxxxxxxxxxVPRQGLVVPRQGLxxxxxxxxxxxxxxxxPRQGLVVPRQG LVVPRQGLVVPRQGLVVPRQGLVVPRQGLVVPRQGLVVxRQGLVVPxxxL VVPRQGxxVPRQGLVVPRQGLVVPRQGLVVPRQGLVVPRQGLVVPRQGLV VPRQGLVVPRQGLVVPRQGLVVPRQGLVVPRQGLVVPRQGLxxxRQGLVV PRQGLVVPRQGLVVPRQGLVVxxxxxVVPRQGLVVPRQGLVVPRQGLVVP RQGLVVxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxR QGLxxxRQxxxxxxxxxxxx---x-----------xxxxxPRQxxVVPRQ GLV-----------VPxx-------------------------------- -------------------------------------------------- -------------------------------------------------- ----ELNSSASSRRKRRVPMKRAPPTRKERVTRQRADKKERKESEEEPLN ------AVKEEVKEEPMPASKADFEDNFLFGDDVGAGIEDSSEEDA-EEE EEE-EEDQSFDPKKKQVSGAANERKKKRKKGLGKMCSSKLPRTKSVLEGY PWQCTDCTSILPTLQELRTHHQ---------------------------- -------------------------VKHSQLPNFKCVQCAKVYTRYRSFA RHVKLHRNPKKF---------------RCEECGKCFSQKTVLQSHSTVHT DARPHVCPQCGKAFKQFSSLYLHSKCHLPDQTKPKFPCGVCQKEFATKHT LETHRKIHTGERNFICDVCGKSFIAKGSLDYHILTHSGEKPHHCPVCGKx SVLVILRRYSLAQVNVTKHWEISARILVGFKTARLLGKHATLHTGIKPHQ CDVCGKQFRERGALREHNRIHTGAMPYTCEFCGKNFRFKGILTVHRRQHT GERPYGCTDCRREFTNWANYNKHMKRRHRNDNDPSAPTRSANTRTYHPPA ASIAANTAPVVYSNLTGGAGDNSNSSTLTQNSGMYSLQNNHSNLTSAVAK MAAANLYNQHLASNKMAAVFQHGAGANHASKMANVFHQQDSQDSLDRSNH SSTSGNVASNPLMGSYHVPSYVPAGLPMGSMGYYIPPIHHSDPSMDMLQH RMANNQ >Tcm M------RAxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx-- ---------------xx--------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -----------------------xLVVPRQGLVxxxxxxxxx-------x xxxxx-xxxxxxxxxxxxxx---x-----------xxxxxxxxxxxxxxx xxx-----------VPxx-------------------------------- -------------------------------------------------- -------------------------------------------------- ----ELNSSASSRRKRRVPMKRAPPARKERVTRQRADKKDRKECEEEPVN ------VVKEEVKEEPLPAAKPDFEDTFLFGDDVGAGIEDSSEEEA-EEE EEE-EEDRSFDPKKKQVSGATNDRKKKRKKGLGKMCSSKLPRTKSVLEGY PWQCTDCTSILPTLQELRTHHQ---------------------------- -------------------------VKHSQLPNFKCVQCAKVYTRYRSFA RHVKLHRNPKKF---------------RCEECGKCFSQKTVLQSHSTVHT DARPHVCPQCGKAFKQFSSLYLHSKCHLPDQTKPKFPCGVCQKE------ -------------------------------------------------- -----------------------------FKTARLLGKHATLHTGIKPHQ CDVCGKQFRERGALREHNRIHTGAMPYTCEFCGKNFRFKGILTVHRRQHT GERPYGCTDCRREFTNWANYNKHMKRRHRNDNDPSAPTRSANTRTYHPPA ASIAANTAPVVYSNLTGGAGDNSNSSTLTQNSGMYSLQNNHSNLTSAVAK MAAANLYNQHLASNKMAAVFQHGAGANHTSKMANVFHQQDSQDSLDRSNH SSTGGNVASNPLMGSYHVPSYVPAGLPMGSMGYYIPPIHHSDPSMDMLQH RMANNQ >Tps x------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ---------------------------------------xxx-------x xxxxx-xxxxx-xxxxx----------------------xxxxxxxxxxx xxxxxxxxxxxxxxxxxx------------------------xxxxxxxx xxxxxxxxxxxxxxx----------------------------------- -------------------------------------------------- ----ELNSSASSRRKRRVPMKRAPPARKERVTRQRADKKDRKECEEEPVN xxx---VVKEEVKEEPLPAAKPDFEDTFLFGDDVGAGIEDSSEEEA-ExE xxxxEEDRSFDPKKKQVSGATNDRKKKRKKGLGKMCSSKLPRTKSVLEGY PWQCTDCTSILPTLQELRTHHQ---------------------------- -------------------------VKHSQLPNFKCVQCAKVYTRYRSFA RHVKLHRNPKKFSMGPIYLSCTVCRCYRCEECGKCFSQKTVLQSHSTVHT DARPHVCPQCGKAFKQFSSLYLHSKCHLPDQTKPKFPCGVCQKE------ -------------------------------------------------- -----------------------------FKTARLLGKHATLHTGIKPHQ CDVCGKQFRERGALREHNRIHTGAMPYTCEFCGKNFRFKGILTVHRRQHT GERPYGCTDCRREFTNWANYNKHMKRRHRNDNDPSAPTRSANTRTYHPPA ASIAANTAPVVYSNLTGGAGDNSNSSTLTQNSGMYSLQNNHSNLTSAVAK MAAANLYNQHLASNKMAAVFQHGAGANHTSKMANVFHQQDSQDSLDRSNH SSTGGNVASNPLMGSYHVPSYVPAGLPMGSMGYYIPPIHHSDPSMDMLQH RMANNQ