>Tms ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------MLANYTATRTPDSGRPYSFQVLRKGAAGLHLAADGEESA TRWLAVVSHSIERNA--------------------------------------QMDEWLD ISKRNLKLSPSAVQQPDCFGYLMKLGEKWKSWKRRYCVLKDACLFFYKDGTSDSAL---- ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------GMVCLHGYRIQNSTAG GKRFAFEILPPEPRQRHFYFHTDTEMDKKR---WLAALEY----------------SIDR WIK----------------------------VG >Tps MR---------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------SY---- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------INEKVAAPFLK------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------TEI--------------------------------- ----------------------------------NGTAHCD------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------------------D--- ---------------HMIPSICR------------------------------------- ------------------------------------------------------------ -----------------------------------------------------KCDKTVV VRRESGEFGFRIHGSRPVVVSAIEPDTPA--ETSGLEVGDIVISVNSVNVLEASHSEVVK LAHAGSDTLQLEVARTCNVLTPVVREPGAGSPLYSGYLWKLRTCDSGNNNRKWIERWFCL KRDNCLYYYKNDNESQPLGALMLANYTATRTPDSGRPYSFQVLRKGAAGLHLAADGEESA TRWLAVVSHSIERNA--------------------------------------QMDEWLD ISKRNLKLSPSAVQQPDCFGYLMKLGEKWKSWKRRYCVLKDACLFFYKDGTSDSALV--- ------------------------------------------------------------ -------------------------------------IQFMYSSPMASLVLSDCSQLTAD GFEKLP------------------DQLMYPYTKPYDLQKHVFSNWMVCLHGYRIQNSTAG GKRFAFEILPPEPRQRHFYFHTDTEMDKKRSGDRAVAIDFLQEAAITSLSSGS---NVKW EM------------------------------- >Tce ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------ECDKTVV VRRESGEFGFRIHGSRPVVVSAIEPDTPA--ETSGLEVGDIVISVNSVNVLEASHSEVVK LAHAGSDTLQLEVARTCNVLTPVVREPGAGSPLYSGYLWKLRTCDSGNNNRKWIERWFCL KRDNCLYYYKNDNESQPLGALMLANYTATRTPDSGRPYSFQVLRKGAAGLHLAADGEESA TRWLAVVSHSIERNA--------------------------------------QMDEWLD ISKRNLKLSPSAVQQPDCFGYLMKLGEKWKSWKRRYCVLKDACLFFYKDGTSDSAL---- ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------GMVCLHGYRIQNSTAG GKRFAFEILPPEPRQRHFYFHTDTEMDKKR-----------------------------W --------------------------------- >Tsi SA-VPI------------------HEPPLL--------ALLALTRRHCKKPFLTKD---- --------------------------TEISLLCLSRSHLGKLCNTI-------------- ------------------------------------------------------------ ---------LLRRLERVVTKPPKDVVMSPSQSRRALRRRRSPAGYRTPDSSTEQHSLESI DSLTRNNGSTADLLLGRTDSGKTGTDISETSTTEDYVTANDNNSGTDTSSRRSVSYHLPK DRGGGQGAAGVGGGSVGAGDCSSFESASSMYSLARGELNSDELAQVCCSPPPIMEENSSD VPSTPQLESEDNQASTTPRVSIDMTAVQKKGSGHEGTSPSGDSSSSSGSYSVEGSSNDLD KLPPSTVSPAPSADRNRHQAKGGSVSDEEHSGHYSSSGYYESPADEEEEAEGYELGRYRT PVLFHFD--------------------------ISVSGGERREWTEEEKRKKKNAFKLDF SPITDKEEIILQPTVHHHKHKDSSSETWSRRSSAKSDRSSGKSDRSSGKSERSGRSEAIR TPTRSPPDSEGSRKTTPSRRGKSRSRSPVQHHRRVPSTLPGVAQAIAKKAHRDKSDKEPI TPGMVRSPAMHEGFRTEDWGTLQRTTPVHTPEEVAPVSANNIGTRQL------------- ----EHRTSPVKVWNALQLNNSHLRGDIAGYETVLAENKAPGVGEEVQQPPRKEYNLPTG MLQRIGSCAVGVWGMGIDNWAPPSGRDTHTVYSKPISDNRTRRRSGSTEEKSAGSAATLA RRR-----------SSIPAKSPGSGLGEGTGGEDPSAQTLVPKGSRLSPHRYSRSPASSP SRRLKSKGSPKMIADSSSKGTISPDSTRLKALSAESLRSVSPGSDSVFYSESADHSSNAA NLTDNQGVLCHHCGREVDKSTLSGVE---------------------------------- ----------------------------------DGEGPCESVETEQPDIVQPPAGFADS PEGPRSMKPSSGRLYKKLEKRFRSEDRGGHGERRHHSRFRCEGVRAKSEERGKEDRVKVS -------------------------------------PGKGASRIVSRSGEFLWRVCKQS E------RKETIDECVKD------------------------------------------ ------------------------------------------------------------ ---------------------------WPLARSTDANDKSGDNAESTSIGVVRRGSSEST GSEKDFRRKYQAITHRMVHRKSSVEMYKRLQSKSFA------------------------ --------------------------------------------------------DTSR CVHTSLHQALENILHQMLMVWCKQTLAIKVVSGEKDGCLPSGEIKENFGISR-------- -----------------------------------------------------EFEVVRG KNRNKQTNNNY---DIALAFWPPLC----------------------------------- ------SLVVRVSGHRSSILGFDLWCFQAYCEAVGLKQDQLNLNVTRLSSCEENQER--- -----SDTLQLEVARTCNVLTPVVREPGAGSPLYSGYLWKLRTCDSGNNNRKWIERWFCL KRDNCLYYYKNDNESQPLGALMLANYTATRTPDSGRPYSFQVLRKGAAGLHLAADGEESA TRWLAVVSHSIERNA--------------------------------------QMDEWLD ISKRNLKLSPSAVQQPDCFGYLMKLGEKWKSWKRRYCVLKDACLFFYKDGTSDSALA--- ------------------------------------------------------------ -------------------------------------IQFMYSSAMASLVLSDCSQLTAD GFEKLP------------------DQIMYPYTKPYDLKK-----RMVCLHGYRIQNSTTG GKRFAFEILPPEPRQRHFYFHTDTEMDKKRSGDWAVAIDFLQEAAITSLSSVS---NVKR EM------------------------------- >Tcm ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------MEVLKTA DSSPNMARDNSVSDLLTDDEEDQDT----------------------------------- ------------------------------------------------------------ --GIYTDSYKNSTWIYIGDSEEIHVWQKPDTRADDKDDKSGDNAESTSIGVARRGSSEST GSEKDFRRKYQAITHRMVHRKSSVEMYKRLQSKSFA------------------------ --------------------------------------------------------DMSR CVHTSLHQALENILHQMLMVWCKQTLAIKVVSGEKD------------------------ ------------------------------------------------------------ -----------------------------------------------------ECDKTVV VRRESGEFGFRIHGSRPVVVSAIEPDTPA--ETSGLEVGDIVISVNSVNVLEASHSEVVK LAHAGK------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------- >Tdi ------------------------------------------------------------ --------------------------------------MEKLCNTI-------------- ------------------------------------------------------------ ---------LLHRLERVVTKPPKDVVMSPSQSRRALRRRRSPAGYRTPESSTEQHSLESI DSLTRNNGSTADLLLGRTDSG-------XTSTTEDYVTANDNNSGTDTSSRRSVSYHLPK DRGGGQGAAGVGGGSAGAGDCSSFESASSMYSLARGELNSDELAQVCCSPPPIMEENSSD VPSTPQLESEDNQASTTPRVSIDMTAVQKKGSGHEGTSPSGDSSSSSGSYSVEGSSNDLD KLPPSTVSPAPSADRNRHQAKGGSVSDEEHSGHYSSSGYYESPADEEEEAEGYDLGRYRT PVLVHFD--------------------------IGVSGGERREWTEEEKRKKKNAFKLDF SPITDKEEIILQPTVHHHRHKDSSSETWSRRSSAKSDRSSGKSDRSSGKSERSGRSEAIR TPTRSPPDSEGSRKTTPSRRGKSRSRSPVQHHRRVPSTLPGVAQAIAKKAHRDKSDKEPI TPGMVRSPAMHEGFRTEDWGTLQRTTPVHTPEEAAPVSANNIGTSDESSQSVECTAAQQQ SSPRRHR----RVRDSPRRKQGSGSGGRSPTATTQRTRRRSGSTEE-------------- --------------------------------------------------KSAGSAATLA RRR-----------SSIPAKSPGSGLGEGTGGEDPSAQSLVPKGSRLSPHRYSRSPAGSP SRRLKSKGSPKMIADSSSKGTISPDSTRLKALSAESLRSVSPGSDSVFYSESADHSSNAA NLTDNQGVLCHHCGREVDKSTLSGVELLICPHEAELASFQTHCFTENSEAPRIEPKTSGS VTINFDHYLDHKEGLCFHYGTAYMISGYTEISQDDGEGPCESVETEQPDIVQPPAGFADS PEGPRSMKPSSGRLYKKLEKRFRSEDRGGHGERRHHSRFRCEGVRAKSEERGKEDRVKVS SFGEFESQVQGKGQAGLCQGQVSSSGEFASQVGERGKRDCVKVRPLARSTDASMEVLKTA DSSPNMARDNSVSDLLTDDEEDQDT----------------------------------- ------------------------------------------------------------ --GIYTDSYKNSTWIYIGDSEEIHVWQKPDTRADDKDDKSGDNAESTSIGVARRGSSEST GSEKDFRRKYQAITHRMVHRKSSVEMYKRLQSKSFA------------------------ --------------------------------------------------------DTSR CVHTSLHQSLENILHHMLMVWCKQTLAIKVVSGEND------------------------ ------------------------------------------------------------ -----------------------------------------------------ECDKTVV VRRESGEFGFRIHGSRPVVVSAIEPDTPA--ETSGLEVGDIVISVNSVNVLEASHSEVVK LAHAGSDTLQLEVARTCNVLTPVVREPGAGSPLYSGYLWKLRTCDSGNNNRKWIERWFCL KRDNCLYYYKNDNESQPLGALMLANYTATRTPDSGRPYSFQVLRKGAAGLHLAADGEESA TRWLAVVSHSIERNA--------------------------------------QMDEWLD ISKRNLKLSPSAVQQPDCFGYLMKLGEKWKSWKRRYCVLKDACLFFYKDGTSDSALVIQF MYSSPMASLVLSDCSQLTADGFEKLPDQLMYPYTKPYDLQKHVFSNCHFDIPLKRTQCHQ TAIKLYRQNEPLSFVKDSANFFGERVSCGQPNKPYGLMIPMINILVTIMFHSQGWCASMD TEYKTPPLAGKGLPLKFFHPNLDNDISTSTLTQRWTRNDGSLPSNTLLTVGLKSADASAS DVQ-----LPNTKKAKKL-----TKKQLCLSLNANTGPPHLEEERKLSLENDTEDMHWQW DLKVWVLPAHTLRNTVVACGMLPVEVRLHRTVL >Tte ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------MSPVKVWNAQQPNNSHLPGDIAGYETVLAENKAPGVVEEVQQPPLK------- --------------------------------------------------EPADVVAALK KRALPRLRLWLAGVPPSPPSSPGSGLGEGTGGEDASAQSLVPKGSRLSPHRYSRSPASSP SRRLKSKGSPKMIADSSSKGTISPDSTRLKALSAESLRSVSPGSDSVFYSESADHSSNAA NLTDNQGVLCHHCGREVDKSTLSGVE---------------------------------- ----------------------------------DGEGPCEKVETEQPDIVQPPAGFADS PEGPRGMKPSSGRLYKKLEKRFRSEDRGGHGERRHHSRFRCEGVRAKSEERGKEDRVKVS LRAKSE---------------------------ERGKEDRVKVRPLARSTDASMEVLKTA DSSPNMARDNSVSDLLTDDEEDQDTVFLPLQSHVLQHPHYLPILSQSSFLLLSHVLQHPH YLPILSQSSFLYYLMYSTYPHSFPDDFLVTANMLLTNFIPMSSTFLVSLIFNIHVSAACE TMGIYTDSYKNSTWIYIGDSEEIHVWQKPDTRADDKDDKSGDNAESTSIGVTRRGSSEST GSEKDFRRKYQAITHRMVHRKSSVEMYKRLQSKSFA------------------------ --------------------------------------------------------DTSC CVHTSLHQALENILHQMLMVWCKQTLANKVVSGEND------------------------ ------------------------------------------------------------ -----------------------------------------------------ECDKTVV VRRESGEFGFRIHGSRPVVVSAIEPDTPA--ETSGLEVGDIVISVNSVNVLEASHSEVVK LAHAGSDTLQLEVARTCNVLTPIVREPGAGSPLYSGYLWKLRTCDSGNNNRKWIERWFCL KRDNCLYYYKNDNESQPLGALMLANYTATRTPDSGRPYSFQVLRKGAAGLHLAADGEESA TRWLAVVSHSIERNA--------------------------------------QMDEWLD ISKRNLKLSPSAVQQPDCFGYLMKLGEKWKSWKRRYCVLKDACLFFYKDGTSDSALV--- ------------------------------------------------------------ -------------------------------------MIPMINILVTIMIRSQGWCASMD TEYKTPPLAGKGLSLKFFHPNLDNDISTSTLTQRWTRNDGSLPSNTLSTVGLKSADASAS DVQ-----LPNTKKAKKL-----TKKQLRLSFDANAGPPHLEEERKLSLENG----HHSY QLL----------------------------AT >Tbi MEHLPVPSDMGICDEEEEEDGVCEREQEMLEKNGDISSTIVSLAQR--SSPFASSDSLAN DVKDHSDSIWNESQATVLHADSDNNGTGIS--CSDLSSLSALCPAVLSLTPSSRRKQLLL LQHQQRSSMDTEALDEEFDASQVPQGPPSPRLRVEGPQYPRPTFSVTTPSQDEPTEPDDA VVPNKRPSPLAEKLERVVTKPPRDVVMSPSQSRRALRRRRSPAGYRTPDSSTEQHSLESI DSLTRNNGSTADLLLGRTDSGKTGTDISETSTTEDYVTANDNNSGTDTSSRRSVSYHLPK DRGGGQGAAGVGGGSAGAGDCSSFESASSMYSLTRGELNSDELAQVCCSPPPIMEENSSD VPTTPQLESEDNQASTTPRVSIDMTTAQKKGSGHEGTSPSGDSSSSSGSYSVEGSSNDLD KLPPSTISPAPSADKNRHRAKGGSVSDEEHSGHYSSSGYYESPADGEEEAEGYNLGRSRT PALPEHRWKDNIRMNLKERGCKEVDWIELAQDMVRVSGGERREWTEEEKRKKKNAFKLDF SPNMDKEEIILQPTAHHHKHKDSSSETWSRRSSAKSDRSSGKSDRSSGKSERSGRSEAIR TPTRSPPDSEGSRKTTPSRRGKSRSRSPVQHHRRVPSTLPGVAQAIAKKAHRDKSDKEPI TPGMVRSPAMHEGFRTEDWGTLQRTTPVHTPEEAAPVSANNIGTCQLVLQLYEQQHVDHI RGCVEHRMSPVKVWNALQPNNSHLPGDIAGYETVLAENKAPGVGEEVQQPPLK------- ------------------------------VYSKPISDNRTRRRSGSTEEKSAGSAATLA RRR-----------SSIPAKSPGSGLGEGTGGEDASAQSLVPKGSRLSPHRYSRSPASSP SRRLKSKGSPKMIADSSSKGTISPDSTRLKALSAESLRSVSPGSDSVFYSESADHSSNAA NLTDNQGVLCHHCGREVDKSTLSGVE---------------------------------- ----------------------------------DGEGPCERVETEQPDIVQPPAGFADS PEGPRGMKPSSGRLYKKLEKRFRSEDRGGHGERRHHSRFRCEGVRAKSEERGKEDRVKV- -------------------------------------------RPLARSTDASMEVLKTA DSSPNMARDNSVSDLLTDDEEDQDT----------------------------------- ------------------------------------------------------------ --GIIII----IIIIIIINSLQ----PKPDTRADDKDDKSGDNAESTSIGVTRRGSSEST GSEKDFRRKYQAITHRMVHRKSSVEMYKRLQSKSFGPPRAALSRQGALSRHCWRSPQLSA LTLHNMMKLNYLLQYLHGFKFLLLQQTGLLKTGILGFESQLCLVKVASHPPSRYKTDTSC CVHTSLHQALENILHQMLMVWCKQTLAIKVVSGEND-----AKIKIKVGSHRVKCTTHDL IVCVLTQWELMVKNPSIVHNFYRWCSYIIHLGVELTTPSDVYSHLNKSGSGPDAFVVTRR NPRRQLSDNPYKNDDISSALLPPLCGLMFRVSGYRSRSPGFDLGCFQPYFEAVECDKTVV VRRESGEFGFRIHGSRPVVVSAIEPDTPA--ETSGLEVGDIVISVNSVNVLEASHSEVVK LAHAGSDTLQLEVARTCNVLTPIVREPGAGSPLYSGYLWKLRTCDSGNNNRKWIERWFCL KRDNCLYYYKNDNESQPLGALMLANYTATRTPDSGRPYSFQVLRKGAAGLHLAADGEESA TRWLAVVSHSIERNAQVSEWTNRNEGGGIAEIISNTSVCDLYVGLSSRNLQCMQMDEWLD ISKRNLKLSPSAVQQPDCFGYLMKLGEKWKSWKRRYCVLKDACLFFYKDGTSDSALV--- ------------------------------------------------------------ -------------------------------------MIPMINILVTIMIHSQGWCASMD TEFKTPPLAGKGLSLKFFHPNLDNDISTSTLTQRWTRNDGSLPSNTLSTVGLKSADASAS DVQ-----LPNTKKAKKL-----TKKQLRLSFDANAGPPHLEEERKLSLENG----HHSY QLL----------------------------AT