>Tms -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- 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-------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ---------------------------------------------MLANY TATRTPDSGRPYSFQVLRKGAAGLHLAADGEESATRWLAVVSHSIERNA- -------------------------------------QMDEWLDISKRNL KLSPSAVQQPDCFGYLMKLGEKWKSWKRRYCVLKDACLFFYKDGTSDSAL -------------------------------------------------- xxxxxxGxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx---- ------------------------xxxxxxxxxxxxxxxx---------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- --------------- >Tps x------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- 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-------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ----------------xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxK CDKTVVVRRESGEFGFRIHGSRPVVVSAIEPDTPAETSGLEVGDIVISVN SVNVLEASHSEVVKLAHAGSDTLQLEVARTCNVLTPVVREPGAGSPLYSG YLWKLRTCDSGNNNRKWIERWFCLKRDNCLYYYKNDNESQPLGALMLANY TATRTPDSGRPYSFQVLRKGAAGLHLAADGEESATRWLAVVSHSIERNA- -------------------------------------QMDEWLDISKRNL KLSPSAVQQPDCFGYLMKLGEKWKSWKRRYCVLKDACLFFYKDGTSDSAL VxxxxYxxxxxxxxxSDCSQLTxxxxxxxxDQLMYPYTKPYDLQKHVFSN WMVCLHGxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx xxxxxxxxxxxxxxxxxxxxxxxxx------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- --------------- >Tce -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------E CDKTVVVRRESGEFGFRIHGSRPVVVSAIEPDTPAETSGLEVGDIVISVN SVNVLEASHSEVVKLAHAGSDTLQLEVARTCNVLTPVVREPGAGSPLYSG YLWKLRTCDSGNNNRKWIERWFCLKRDNCLYYYKNDNESQPLGALMLANY TATRTPDSGRPYSFQVLRKGAAGLHLAADGEESATRWLAVVSHSIERNA- -------------------------------------QMDEWLDISKRNL KLSPSAVQQPDCFGYLMKLGEKWKSWKRRYCVLKDACLFFYKDGTSDSAL -------------------------------------------------- xxxxxHGxxxxxxxAGGKRFAFExxxxxxxxxxxxxxxxxxxxxxx---- ------------------------x------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- --------------- >Tsi SAVPIH-------------------------------------------- -------------------------------------------------- -------------------------------------------------- ----------------------------------------EPPLLALLAL TRRHCKKPFLTKDTEISLLCLSRSHxxKLCNTILLRRLERVVTKPPKDVV MSPSQSRRALRRRRSPAGYRTPDSSTEQHSLESIDSLTRNNGSTADLLLG RTDSGKTGTDISETSTTEDYVTANDNNSGTDTSSRRSVSYHLPKDRGGGQ GAAGVGGGSVGAGDCSSFESASSMYSLARGELNSDELAQVCCSPPPIMEE NSSDVPSTPQLESEDNQASTTPRVSIDMTAVQKKGSGHEGTSPSGDSSSS SGSYSVEGSSNDLDKLPPSTVSPAPSADRNRHQAKGGSVSDEEHSGHYSS SGYYESPADEEEEAEGYELGRYRTPVLFHFDIS----------------- ----------------VSGGERREWTEEEKRKKKNAFKLDFSPITDKEEI ILQPTVHHHKHKDSSSETWSRRSSAKSDRSSGKSDRSSGKSERSGRSEAI RTPTRSPPDSEGSRKTTPSRRGKSRSRSPVQHHRRVPSTLPGVAQAIAKK AHRDKSDKEPITPGMVRSPAMHEGFRTEDWGTLQRTTPVHTPEEVAPVSA NNIGTRQL-----------------EHRTS-------------------- -------------------------------------------------- ---PVKVWNALQLNNSHLRGDIAGYExVLAENKAPGVGEEVQQPPRKExx LPTGMLQRIGSCAVGVWGMGIDNWAPPSGRDTHTxxxKPISDNRTRRRSG STEEKSAGSAATLARRRSSIPA--------------------------KS PGSGLGEGTGGEDPSAQTLVPKGSRLSPHRYSRSPASSPSRRLKSKGSPK MIADSSSKGTISPDSTRLKALSAESLRSVSPGSDSVFYSESADHSSNAAN LTDNQGVLCHHCGREVDKSTLSGVE------------------------- -------------------------------------------DGEGPCE SVETEQPDIVQPPAGFADSPEGPRSMKPSSGRLYKKLEKRFRSEDRGGHG ERRHHSRFRCEGVRAKSEERGKEDRxxxx--------------xxxxxxx xxxxxxxxxxxxxxxxxxxxxxxxxxxxx--------------------- ---------xxxxxxxx--------------------------------- -------------------------------------------------- -------------------------------------------------- --------------------------------------------NDKSGD NAESTSIGVVRRGSSESTGSEKDFRRKYQAITHRMVHRKSSVEMYKRLQS KSF----------------------------------------------- ---------------------------------ADTSRCVHTSLHQALEN ILHQMLMVWCKQTLAIKVVSGEKDxxxxxxxxxxxFGISREFEVVRGKNR NKQTNNxxxxxxx------------------------------------- -------------------------------------------------- ----------xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx xxxxxxxxxxxxxxxxx--------------------------------- -------------------------------------------------- -------------------SDTLQLEVARTCNVLTPVVREPGAGSPLYSG YLWKLRTCDSGNNNRKWIERWFCLKRDNCLYYYKNDNESQPLGALMLANY TATRTPDSGRPYSFQVLRKGAAGLHLAADGEESATRWLAVVSHSIERNA- -------------------------------------QMDEWLDISKRNL KLSPSAVQQPDCFGYLMKLGEKWKSWKRRYCVLKDACLFFYKDGTSDSAL AxxxxYxxxxxxxxxSDCSQLTxxxxxxxxDQIMYPYTKPYDLKKR---- -xxxxxxxxxxxxxxGGKRFAFExxxxxxxxxxxxxxxxxxxxxxxxxxx xxxxxxxxxxxxxxxxxxxxxxxxx------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- --------------- >Tcm -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ------------------MEVLKTADSSPNMARDNSVSDLLTDDEEDQDT -------------------------------------------------- -------------------------------------------------- ----------GIYTDSYKxxxxxxxxxxxxxxxxQKPDTRADDKDDKSGD NAESTSIGVARRGSSESTGSEKDFRRKYQAITHRMVHRKSSVEMYKRLQS KSF----------------------------------------------- ---------------------------------ADMSRCVHTSLHQALEN ILHQMLMVWCKQTLAIKVVSGEKD-------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------E CDKTVVVRRESGEFGFRIHGSRPVVVSAIEPDTPAETSGLEVGDIVISVN SVNVLEASHSEVVKLAHAGK------------------------------ -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- --------------- >Tdi xx------------------------------------------------ -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ---------------------------KLCNTILLHRLERVVTKPPKDVV MSPSQSRRALRRRRSPAGYRTPESSTEQHSLESIDSLTRNNGSTADLLLG RTDSGXT-------STTEDYVTANDNNSGTDTSSRRSVSYHLPKDRGGGQ GAAGVGGGSAGAGDCSSFESASSMYSLARGELNSDELAQVCCSPPPIMEE NSSDVPSTPQLESEDNQASTTPRVSIDMTAVQKKGSGHEGTSPSGDSSSS SGSYSVEGSSNDLDKLPPSTVSPAPSADRNRHQAKGGSVSDEEHSGHYSS SGYYESPADEEEEAEGYDLGRYRTPVLVHFDIG----------------- ----------------VSGGERREWTEEEKRKKKNAFKLDFSPITDKEEI ILQPTVHHHRHKDSSSETWSRRSSAKSDRSSGKSDRSSGKSERSGRSEAI RTPTRSPPDSEGSRKTTPSRRGKSRSRSPVQHHRRVPSTLPGVAQAIAKK AHRDKSDKEPITPGMVRSPAMHEGFRTEDWGTLQRTTPVHTPEEAAPVSA NNIGT------------------------SxESSQSVxxxxAQQQSSPxx xxxxxxxxxxxxxSGSGxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx xxxxxx-------------------------------------------- -------------------------------------------------- -------------------------------------------------S PGSGLGEGTGGEDPSAQSLVPKGSRLSPHRYSRSPAGSPSRRLKSKGSPK MIADSSSKGTISPDSTRLKALSAESLRSVSPGSDSVFYSESADHSSNAAN LTDNQGVLCHHCGREVDKSTLSGVELLICPHEAELASFQTHCFTENSEAP RIEPKTSGSVTINFDHYLDHKEGLCFHYGTAYMISGYTEISQxDGEGPCE SVETEQPDIVQPPAGFADSPEGPRSMKPSSGRLYKKLEKRFRSEDRGGHG ERRHHSRFRCEGVRAKSEERGKEDRxxxx-----xxxxxxxxVQxxx--- ----------------------------xxGLCQxxxxxxxxxxxxxxxx xxxxxxxVRPLARSTDASMEVLKTADSSPNMARDNSVSDLLTDDEEDQDT -------------------------------------------------- -------------------------------------------------- ----------GIYTDSYKxxxxxxxxxxxxxHVWQKPDTRADDKDDKSGD NAESTSIGVARRGSSESTGSEKDFRRKYQAITHRMVHRKSSVEMYKRLQS KSF----------------------------------------------- ---------------------------------ADTSRCVHTSLHQSLEN ILHHMLMVWCKQTLAIKVVSGEND-------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------E CDKTVVVRRESGEFGFRIHGSRPVVVSAIEPDTPAETSGLEVGDIVISVN SVNVLEASHSEVVKLAHAGSDTLQLEVARTCNVLTPVVREPGAGSPLYSG YLWKLRTCDSGNNNRKWIERWFCLKRDNCLYYYKNDNESQPLGALMLANY TATRTPDSGRPYSFQVLRKGAAGLHLAADGEESATRWLAVVSHSIERNA- -------------------------------------QMDEWLDISKRNL KLSPSAVQQPDCFGYLMKLGEKWKSWKRRYCVLKDACLFFYKDGTSDSAL VxxxxYxxxxxxxxxSDCSQLTxxGFEKLPDQLMYPYTKPYDLQKHVFS- -------------------------------------------------- ---------------------------------------Nxxxxxxxxxx xxxxxxxxxxxxNEPLSFVKDSANFFGERVSCGQPNKPYxxxxxxxxxxx xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx RNDGSLPSNTLLTVGLKSADASAxxxxxxxxxKAKKLTKxQxCLSLNANT GPPHLEEERKxSLEND--------xxxxxxxxxxxxxVLPAHTLRNTVVA CGMLPVEVRLHRxxx >Tte xx------------------------------------------------ -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ---PVKVWNAQQPNNSHLPGDIAGYETxLAENKAPGVVEEVQQPPLKx-- -------------------------------------------------- --------------------xxxxxxxxxxxxxxxxxxxxxxxxxxxxSS PGSGLGEGTGGEDASAQSLVPKGSRLSPHRYSRSPASSPSRRLKSKGSPK MIADSSSKGTISPDSTRLKALSAESLRSVSPGSDSVFYSESADHSSNAAN LTDNQGVLCHHCGREVDKSTLSGVE------------------------- -------------------------------------------DGEGPCE KVETEQPDIVQPPAGFADSPEGPRGMKPSSGRLYKKLEKRFRSEDRGGHG ERRHHSRFRCEGVRAKSEERGKEDRVKVSxRAKSE--------------- ------------------------------------------------ER GKExxxxVRPLARSTDASMEVLKTADSSPNMARDNSVSDLLTDDEEDQDT xxx-------------xxxxxxxQHPHYLPILSQSSFLLxxxVLQHPHYL PILSQSSFLYYLMYSTYPHSFPDDFLVTANMLLTNFIPMSSTFLVSLIFN IHVSAACETxGIYTDSYKxxxxxxxxxxxxxHVWQKPDTRADDKDDKSGD NAESTSIGVTRRGSSESTGSEKDFRRKYQAITHRMVHRKSSVEMYKRLQS KSF----------------------------------------------- ---------------------------------ADTSCCVHTSLHQALEN ILHQMLMVWCKQTLANKVVSGEND-------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------E CDKTVVVRRESGEFGFRIHGSRPVVVSAIEPDTPAETSGLEVGDIVISVN SVNVLEASHSEVVKLAHAGSDTLQLEVARTCNVLTPIVREPGAGSPLYSG YLWKLRTCDSGNNNRKWIERWFCLKRDNCLYYYKNDNESQPLGALMLANY TATRTPDSGRPYSFQVLRKGAAGLHLAADGEESATRWLAVVSHSIERNA- -------------------------------------QMDEWLDISKRNL KLSPSAVQQPDCFGYLMKLGEKWKSWKRRYCVLKDACLFFYKDGTSDSAL x------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -----------------------------------------xxxxxxxxx xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx RNDGSLPSNTLSTVGLKSADASAxxxxxxxxxKAKKLTKxxxRLSFDANA GPPHLEEERKxSLENGxxxxQxxxx------------------------- --------------- >Tbi Mx---xxxxPSDMGICDEEEEExxxxxREQEMLEKNGDISSTIVSLAQRS SPFASSDxxxNDVKDHSDSIWNESQATVLHADSDNNGxxxxCSDLSSxxx xxxxxLSLTPSSRRKQLLLLQHQQRSSMDTEALDEEFDAxxxxxGPPxxR xxxxxxQYPRxxxxxxxxxxxEPTEPDDAVxxxxxxxxLAE--------- ------------------------------------KLERVVTKPPRDVV MSPSQSRRALRRRRSPAGYRTPDSSTEQHSLESIDSLTRNNGSTADLLLG RTDSGKTGTDISETSTTEDYVTANDNNSGTDTSSRRSVSYHLPKDRGGGQ GAAGVGGGSAGAGDCSSFESASSMYSLTRGELNSDELAQVCCSPPPIMEE NSSDVPTTPQLESEDNQASTTPRVSIDMTTAQKKGSGHEGTSPSGDSSSS SGSYSVEGSSNDLDKLPPSTISPAPSADKNRHRAKGGSVSDEEHSGHYSS SGYYESPADGEEEAEGYNLGRSRTP-------ALPExxWKDNIRMNLKER GCKEVDWIELAQxxVRVSGGERREWTEEEKRKKKNAFKLDFSPNMDKEEI ILQPTAHHHKHKDSSSETWSRRSSAKSDRSSGKSDRSSGKSERSGRSEAI RTPTRSPPDSEGSRKTTPSRRGKSRSRSPVQHHRRVPSTLPGVAQAIAKK AHRDKSDKEPITPGMVRSPAMHEGFRTEDWGTLQRTTPVHTPEEAAPVSA NNIGTCQLVLQLYxxQHVDHIRGCVxHRMS-------------------- -------------------------------------------------- ---PVKVWNALQPNNSHLPGDIAGYExVLAENKAPGVGEEVQQPPLK--- ----------------------------------VxxxxxxxxRTRRRSG STEEKSAGSAATLARRRSSIPA--------------------------KS PGSGLGEGTGGEDASAQSLVPKGSRLSPHRYSRSPASSPSRRLKSKGSPK MIADSSSKGTISPDSTRLKALSAESLRSVSPGSDSVFYSESADHSSNAAN LTDNQGVLCHHCGREVDKSTLSGVE------------------------- -------------------------------------------DGEGPCE RVETEQPDIVQPPAGFADSPEGPRGMKPSSGRLYKKLEKRFRSEDRGGHG ERRHHSRFRCEGVRAKSEERGKEDRVK----------------------- -------------------------------------------------- -------VRxLARSTDASMEVLxxxxxxxxxxxDNSVSDLLTDDEEDQDT xxxxxxxxxxxxxxxxx--------------------------------- -------------------------------------------------- -----------------------------------KPDTRADDKDDKSGD NAESTSIGVTRRGSSESTGSEKDFRRKYQAITHRMVHRKSSVEMYKRLQS KSFxPPRAALSRQGALSRHCWRSPQLSALTLHNMMKLNYLLQYLHGFKFL LLQQTGLLKTGILGFESQLCLVKVASHPPSRYKTDTSCCVHTSLHQALEN ILHQMLMVWCKQTLAIKVVSGEND-------------------------- ------------AKIKIxxxxxxxxxTTHDLIVCVLTQWELMVKNPSIVH NxxRWCSYIIHLGVELTTPSDVYSHLNKSGSGPDAFVVTRRNPRRQLSDx xxKxxxxxxxxxxxxxxLMFRVSGYRxxSPGFDLGCFQPYxxxx------ -------------------------------------------------E CDKTVVVRRESGEFGFRIHGSRPVVVSAIEPDTPAETSGLEVGDIVISVN SVNVLEASHSEVVKLAHAGSDTLQLEVARTCNVLTPIVREPGAGSPLYSG YLWKLRTCDSGNNNRKWIERWFCLKRDNCLYYYKNDNESQPLGALMLANY TATRTPDSGRPYSFQVLRKGAAGLHLAADGEESATRWLAVVSHSIERNAQ VSEWTNRNEGGGIAEIISNTSVCDLYVGLSSRNLQCMQMDEWLDISKRNL KLSPSAVQQPDCFGYLMKLGEKWKSWKRRYCVLKDACLFFYKDGTSDSAL V------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -----------------------------------------xxxxxxxxx xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx xxxxxxxxxxxxxxxxxxxDxxxxxxxxxxxxKAKxxxxxxxxxxxxxNA GPPHLEEERKxSLENGHHSYQLLAx------------------------- ---------------