>Tge x------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ------------------------------------------------xx xxxxxxxxxxxxxxxxxxxxxxxxGHVLKGLHKSGFKKPSPIQLKAIPLG RCG----------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ----------------------LDLVMQAKSGTGKTCVFTILALEMLINT PSLQVLILAPTREIAVQITHVIRDIGQCIKGMKVESFIGGLPYHEDVKKV EGCQIAVGAPGRIKHLIEAGCMKTDLVRLFVMDEADKLMDDTFVKDINYI FWK----------------------------------------------- -------LPDNKQMIAASATYPNSLEKAVSCYMRTPTHVSPNYDGPVLLG LRQFVMVVPAHANVAAQVKIKIERLMELLSSVTFQQCVVFSNYQTRAESI CNRLNANGWPAMSITGSQDQYARLKAITCLREFRCRVLLSTDLTSRGIDA ENVNLIVNFDVPYSGTTYLHRIGRAGRYGSHGISITLVAEDKELLEFQQM LGLIGGNSMSIARLSRESLKKDLWQCDYSLLKSVHGIVKTAECSHENNED V-------ENNxxxK----------------------------------- -------------------------------------------------- -------------------------------------------------- -----------------------ESKSSKDDFDYKKLSIYNETVKHLHEN NQMSLSKLSNEYK--DTKSLLEYLVSPDDLGEVLERRVMCDDGDTFVNSN NKKGIEPPNEPNSSRTEIYND-NISS-SCYEDFSKKVNLTCSSGKK---- -------------------------------------------------- -------------------------------------------------- -----------------xxxxx---------xxxxxxxxx---------- -------------------------------------------------- ---------xxxxxxxxxxxx----------------------------- -------------------------------------------------- ----------------xx-------------------------------- -------------------------------------------------- -------------------------------------------------- --------------------------------------------- >Tbi xx--VNMDDNNRRSxxxxxxxxxxxxxxxxxxxxLNVLAYCGxxxLVELI GSxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ------FLTICFRSQHFKSRKTAHSLASKPRTKDIFINEDIDFSGMMLS- ------------------------GHVLKGLHKSGFKKPSPIQLKAIPLG RCG----------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ----------------------LDLVMQAKSGTGKTCVFTILALEMLINT PSLQVLILAPTREIAVQITHVIRDIGQCIKGLKVESFIGGLPYHEDVKKV EGCQIAVGAPGRIKHLIEAGCMKTDLVRLFVMDEADKLMDDTFVKDINYI FWK----------------------------------------------- -------LPDNKQMIAASATYPNSLEKAVSCYMRTPTHVSPNYDGPVLLG LRQFVMVVPAHTNVAAQVKIKIERLMELLSSVTFQQCVVFSNYQTRAESI CNRLNANGWPAMSITGSQDQYARLKAITCLREFRCRVLLSTDLTSRGIDA ENVNLIVNFDVPYSGTTYLHRIGRAGRYGSHGISITLVAEDKELLEFQQM LGSIGGNSMSIARLSRESLKKDLWQCDYSLLKSVHGIVTTAECSHENNED V-------ENxxxxKGIKVGMKTKEIINEVQEESKNEIKVAKQSNKLRKN KLKSNSYSTQNMEDVLPIESMQNLIPKTDGIVNEDEKPMCDGFSKC---- ----------------LSLQSSDEITVNKLNVTMKDVSNILLKNTPCTMK LESYNDLIHSLQYFKSDLELDILESKNSKDDFDYNKLSIYNKTIKHLHEN NQMSLSKLSNEYK--DTKSLLEYLVSTDNLGEVLERRVMCDTGDTFVNSN NKKGIEPSNEPNSSRSEIYND-Nxxx-SCYEDFSDKVNLTCSSGKKGFSN VI-CRDTASQGNSSREDEIDPLLNTRGQTFSGGLINYCPKSRYNNWRFNN HTNVIPNQxxxxxxxxxxxxxxxxxxxxxQHxHSASFREYNxxxxxxxxx xxxxxxxxxxxxxxGxx--------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- --------------------------------------------- >Tms x------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ---------------HF--------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -----------------------------VGLKVESFIGGLPYHEDVKKA EGCQIAVGAPGRIKHLIEAGCMKTDLVRLFVMDEADKLMDDTFVKDINYI FWK----------------------------------------------- -------LPDNKQMIAASATYPNSLEKAVSCYMRTPTHVSPNYDGPVLLG LRQFVMVVPAHTNVAAQVKIKIERLMELLSSVTFQQCVVFSNYQT----- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------xxxxxxx xxxxxxxxxxxxxxxxx--------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- --------------------------------------------- >Tsi x------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ---------------HF--------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -----------------------------VGLKVESFIGGLPYHEDVKKV EGCQIAVGAPGRIKHLIEAGCMKTDFVRLFVMDEADKLMDDTFVKDINYI FWK----------------------------------------------- -------LPDNKQMIAASATYPNSLEKAVSCYMRTPTHVSPNYDGPVLLG LRQFVMVVPAHTNVAAQVKIKIERLMELLSSVTFQQCVVFSNYQTRAESI CNRLNANGWPAMSITGSQDQYARLKAITCLREFRCRVLLSTDLTSRGIDA ENVNLIVNFDVPYSGTTYLHRIGRAGRYGSHGISITLVAENKELLEFQQM LGSIGGNSMSIARLSRESLKEDLWQCDYSVFKSVHGIVTTSECSHENNED -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx >Tcm x------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ---------------HF--------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -----------------------------VGLKVESFIGGLPYHEDVKKV EGCQIAVGAPGRIKHLIEAGCMKTDFVRLFVMDEADKLMDDTFVKDINYI FWK----------------------------------------------- -------LPDNKQMIAASATYPNSLEKAVSCYMRTPTHVSPNYDGPVLLG LRQFVMVVPAHTNVAAQVKIKIERLMELLSSVTFQQCVVFSNYQTRAESI CNRLNANGWPAMSITGSQDQYARLKAITCLREFRCRVLLSTDLTSRGIDA ENVNLIVNFDVPYSGTTYLHRIGRAGRYGSHGISITLVAENKELLEFQQM LGSIGGNSMSIARLSRESLKEDLWQCDYSVFKSVHGIVTTSECSHENNED -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx >Tce Mx--VNMDDNNRRS------------------------------------ ------------------------------------xxxxxxxxxxxxxx xxxxxxxxxxx--------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------xxxxxxxxxxxxx xxxxxKFLTLCFRSQHFKSRKTAHSLASKPRTKDIFINEDIDFSGMMLS- ------------------------GHVLKGLHKSGFKKPSPIQLKAIPLG RCG----------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ----------------------LDLVMQAKSGTGKTCVFTILALEMLINT PSLQVLVLAPTREIAVQITHVIRDIGQCIKGLKVESFIGGLPYHEDVKKA EGCQIAVGAPGRIKHLIEAGCMKTDLVRLFVMDEADKLMDDTFVKDINYI FWK----------------------------------------------- -------LPDNKQMIAASATYPNSLEKAVSCYMRTPTHVSPNYDGPVLLG LRQFVMVVPAHTNVAAQVKIKIERLMELLSSVTFQQCVVFSNYQTRAESI CNRLNANGWPAMSITGSQDQYARLKAITCLREFRCRVLLSTDLTSRGIDA ENVNLIVNFDVPYSGTTYLHRIGRAGRYGSHGISITLVAESKELLEFQQM LGSIGGNSMSIARLSRESLKKDLWKCDYSAFKSVHGIVKTSECSHENNED VxxxxxxxxxNTSQKGINVEIKKKEIINQVQKESKNEFKVAKQSNKSRKN KLKSNSYSTQNMKDVLPIESMQNLTLKTDGIVNEDAKSMCNVPSDC---- ----------------LSSQSSDEIIVNKLNVTMKDLSNILMKNTPCTMK LESYNDLIHSLQYFKRDLELNILESKSSKDGFDVNKLRKYNETVKHLHEN NKMSLSKLSNQYKxCDTKSLLEYLVSTDNLGQVHERRDICDNRDRVVNSN NKEGLEPSNELNSSRSEVYNDxxxxS-SCYEDFSDKVNLTCSSGKKGFSD VI-RRGSASQGNISREDEIDPLLNNGGQPFSGGLFNDCPKSRYNNWRFND HTNVIPNQ------------------------------------------ -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -----------------LISVxxxxxxxxxxxxxxxxxxLxxxxxxxxxx xxxxxNKITKExxxxxxxxxxxxxxxxxxxxxxxxxxxxxxKxxxxxxxx xxxxxxxxxxxxxxxxxxxxxxxxxxxxxTxYxLNPGxxxxAFCHxxxxI SSLQYWx-------------------------------------- >Tps M------------------------------------------------- -------------------------------------------------- ----------xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx STxxLALIVTIVGYRSTVQTQIAxxxxxxxxxxVKDxLxxxxxxxxxxxx xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxDxxxxx xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx------------ -------------SQHFKSRKTAHSLASKPRTKDIFINEDVYFSGMMLS- ------------------------GHVLKGLHKSGFKKPSPIQLKAIPLG RCG----------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ----------------------LDLVMQAKSGTGKTCVFTILALEMLINT PSLQVLVLAPTREIAVQITHVIRDIGQCIKGLKVESFIGGLPYHEDVKKV EGCQIAVGAPGRIKHLIEAGCMKTDHVRLLVMDEADKLMDDTFVKDINYI FWK----------------------------------------------- -------LPDNKQMIAASATYPNSLEKAVSCYMRTPTHVSPNYDGPVLLG LRQFVMVVPAHTNVAAQVKIKIERLMELLSSVTFQQCVVFSNYQTRAESI CNRLNANGWPAMSITGSQDQYARLKAITCLREFRCRVLLSTDLTSRGIDA ENVNLIVNFDVPYSGTTYLHRIGRAGRYGSHGIAITLVAENKELLEFQQM LGSIGGNGMSIARLSRESLKKDLWQCDYSVFKSVHGIVTTSECSHENNED VxxxxxxLENNISQEGIDVGMKKKEIINQVQKESTNEFKVAK---KSRKN KLKSNSYSKQNMKDVLPIESMQNLTLKTDGIVNEDTKSMCNAPSEC---- ----------------LSSQSSDEIIVNKLNVTMKDLSNILMQNTPCTTK LESYNDLIHSLQYFKSDLELNILENKGSKDDFDVNKLRNYNETVKHLHEN NQVSLSKLSNQYKxCDTKSLLEYLVSTDSLGEVLERREICDNRDRVVNSK NKKGLEPSNELNSSRSEVYNE-NxxxxSCYEDFSDKVNLTCSSWKKGFSD VIPCRGSASHGNSSREEEIDPILNNGGQPFSGGLINDCPKSRYNNWRFND HTNVIPNQxxxxxxxxx----xxxxxxxxxxxxxxxxRExxxxxxxxxxx xxxxxxxxxxxYMFxYx--------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- --------------------------------------------- >Tpa -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------MIAASATYPNSLEKAVSCYMRTPTHVSPNYDGPVLLG LRQFVMVVPAHTNVAAQVKIKIERLMELLSSVTFQQCVVFSNYQTRAESI CNRLNANGWPAMSITGSQDQYARLKAITCLREFRCRVLLSTDLTSRGIDA ENVNLIVNFDVPYSGTTYLHRIGRAGRYGSHGISITLVADDKELLEFQQM LGSIGGNSMSIARLSRESLKKDLWQCDYSLLKSVHGIVTTAECSHENNED V-------ENNxxxx----------------------------------- -------------------------------------------------- -------------------------------------------------- -----------------------ESKSSKDDFDYNKLSIYNETVKHLHEN NQMSLSRLSNEFK--DTKSLLEYLISTDSLGEMLERRVMCDTGDTFVNSN NKKGIEPSNEPNSSRTEIYND-NISS-SCYEDFSDKVNLTCSSRKKGFSN AI-CRDTASQ---------------------------------------- -------------------------------------------------- -----------------xxxxx---------xxxxxxxxxxxxxxxxxxx xxxxxxxxxxxxxxxxxxxxxxxxxxxx---------------------- -xxxxxxxxx---------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- --------------------------------------------- >Tte Mx--xxxDDNNRRSx----------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ---xxKFLTICFRSQHFKSRKTAHSLASKPRTKDIFINEDIDFSGMMLS- ------------------------GHVLKGLHKSGFKKPSPIQLKAIPLG RCG----------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ----------------------LDLVMQAKSGTGKTCVFTILALEI---- -------------------------------------------------- ------------------------------------------------YI FWK----------------------------------------------- -------LPDNKQMIAASATYPNSLEKAVSCYMRTPTHVSPNYDGPVLLG LRQFVMVVPAHTNVAAQVKIKIERLMELLSSVTFQQCVVFSNYQTRAESI CNRLNANGWPAMSITGSQDQYARLKAITCLREFRCRVLLSTDLTSRGIDA ENVNLIVNFDVPYSGTTYLHRIGRAGRYGSHGISITLVAEDKELLEFQQM LGSIGGNT------------------------------------------ -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ------------------xxxxxxxxxxxxxxxxxxxxxxx--------- ---------------------------xxxxxxxxxxxxxxxxxxxxxxx xxxxxxxxxx---------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- --------------------------------------------- >Tdi MxxxxxxDDNNRRS------------------------------------ -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -----------LRSQHFKSRKTAHSLASKPRTKDIFINEDIYFSGMMLS- ------------------------GHVLKGLHKSGFKKPSPIQLKAIPLG RCGxxQVHDLVNLSRMFCKNGRMDGDIDRRADTSWRVVGWMWTVAKSEVV SKQTKMAGYKSVFVATLFYGYEVIEQVFLSKGQHLTLYLHCIQVEGFSIL HLKTKLFHIQSLPSEVWIREVGQEMIIIYSNVKLFHIQSLPSKVWIHEVG QEMIIIYSSVKLFHIQSLPSKVWIHEVGQEMIIIYSSVKLFHIQSLPSEV WIREVGQEMLISYSSVKLFHQLLDLVMQAKSGTGKTCVFTILALEMLINT PSLQVLVLAPTREIAVQITHVIRDIGQCx--------------------- -------------------------------------------------- --xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx xxxxxxxLPDNKQMIAASATYPNSLEKAVSCYMRTPTHVSPNYDGPVLLG LRQFVMVVPAHTNVAAQVKIKLERLMELLSSVTFQQCVVFSNYQTRAESI CNRLNANGWPAMSITGSQDQYARLKAITCLREFRCRVLLSTDLTSRGIDA ENVNLIVNFDVPYSGTTYLHRIGRAGRYGSHGISITLVAENKELLEFQQM LGSIGGN------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -----------------------xNKGSKDDFDVNKLRNYNETVKHLHEN NQVSLSKLSNQYKxCDTKSLLEYLVSTDSLGEVLERREICDNRDRVVNSK NKKGLEPSNELNSSRSEVYNE-NxxxxSCYEDFSDKVNLTCSSWKKGFSD VIxCRGSASHGNSSREEEIDPILNNGGQPFSGGLINDCPKAKY------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- --------------------xxxxxxxxxxxxxxxxxxxxxxxxxxxxGV xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxLxxx xxxxxxFVIVLPLTAAIx-------------------------------- -------------------------------------------------- -------------------------------------------------- ---------------------------------------------