>Tms x---xxPxxxDLHPVxxxxxxxPNxxxTHHCNL----------------- -------------------------------------------------- -------------------------------------------------- -------VLSRLDRLFVLLETGSSPVTRRAAAQQLGEVQKLHPHELHNLL SRITTYLHSPSWETRIAAGQAVEAVLRHVPQWDPVGSPVKT--------- -------------------------------------------------- ESYSASVALSQVGRMNFQKFSMSNVLANSSHLMGSEGKEFDMEEDVAExx xxxxxxxEIQRARYTMWPMKGFHIARFSGRTVKAITLSINQIADDGEIVV QSQAGExxxxxxKGVDIREKMARQRQQLNxxxxLDTAARIGLDDMSDILE AEDxxxxxxxxRSRSxxxxx------------------------------ -----RPVSEVVLQEGGLSSREMNRARRKARQAVLKQRSREGGGAAGEET GVAEEPDKKRVKTEDSKAFVEGTAAGYGDSVPDSTGSW----GEAxEWPF ESFCDRLCQDLFSLSWEVRHGAATALREVIRLHGAGAGKSANIPKTE--- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ---xxxxxxxxxEDVxxxxxxxLAxDRFGDFVSDQVVAxxxxxCAQxx-- ---------------------------------xxxLxxxxxxxxDGVLR VLVQLLNQREWEARHGGLLGLKYLLAVREDLVRQLLPAAFPHILEGLSDP VDDVGAVAASALIPVAPNVVTELPGQVEATVQRLWDLLLDQDELAAACNS FMGLLAALLSLPDxxxxxxKGRIEKVPFIWLSSATCHIEERTNCYSFPLR RQPLCEVVPRLWPFLSHSTSSVRRATLQTLxxxxxxESAxxxxxxxxxxx xPLLxxxxxxIFQRTLVEPxTEIQDLAEKVWGNLIRYSSLQELLLASCPF VSTWLCLTMQPAKLVIDPALLIHxxxxxx--------------------- ----------ERFGERSTRRPxAFxSLESNCGNxGGVEGGITGAGAGLKC EQKLYLGGxxxxxLAT----xxxNVMRARCMASRMxxxxxCYIVQPAPGI VYSPDVESPVDSFVKVLLVYLNSKSALQRMVVGLVIAEWARLDTLTPACP ETLK---------------------------------------------- -----------------VETLYQNIYLHLETLSLxxxxxxNPNLPVIGIx -------------------CRLHQCLSECVYFDEIAVSFTKLLQEAKDFV AMLKHYKLPLDCAGYDGTSVLTLDQIQQLSGPMAQRLLSAHRLKPRAGET LEERRKAIQSAVSETSSNHLLLNISTQAALAGAVTMLRILPDKLNPVVKP LMESVKREDNEQLQELAAEHLARLVELCVDRNPCPNAKIVSNLCTFLCCD HEYTPKIx------------------------------------------ ------------xxAGKWxxxxxxxxxxxxRSLxxGVCRQEVESTVAISD MFVCLQFAAG---------------------------------EGDSGVE STGDNSRTGTPTGFNTDNYTGILTLTNQQRSAERAVLRRSNSTGGRGPGR PPLTDIPLEELFAVEDSMAKLNKIQRRGAAFALTAITAHFASNLHRRLPK LWEVMIVQLSETVDFATFDPSLLVNNDQGAEDLVSSLQVLEATCPALHSD LLGQxQNYVSINCLGERAENYSQYTRLGLDPDPSVIGSxVFCESSALEHS TTEAGLTPLILYSLSGSQTTNSLNLNRWLTLESYFLSPHTLIMNCFQPIF ASEKESFSKLRLGVFVVSLPPRVTGASHWSWxVLQYLPRMCLLLTHPYRA VRHMAARCLGALAALSSVPVMTHVVDQVLPLLGTIDSDINRQGAVEALAC IIEHLKFGVVPYIVLLVVPLLGRMSDQNQPVRLMATHCFATLIQLMPLDG GVPDPPNLTSQLAQHKARERRFLEQLFNPKSIENYKVPVSIRAELRCYQQ SGVNWLAFLNKYKLHGILCDDMGLGKTLQSICILAGDHFYRHQHYLKTRS PDCVPLPSIVICPPTLTGHWVYEVNKFLPEQFLYPLQYVGPPAERDKMRS LVGQHNLVVASYDIVRKDIDFFSSIKWNYCILDEGHVIKNGKTKV----- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -----------------------------------------------x-- - >Tsi -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------MKARCMASRMxxxxxCYIVQPAPGI VYSPDVESPVDSFVKVLLVYLNSKSALQRMVVGLVIAEWARLDTLTPACP ETLK---------------------------------------------- -------------------------------------------------- -------------------CRLHQCLSECVYFDEIAVSFTKLLQEAKDFV AMLKHYKLPLDCAGYDGTSVLTLDQIQQLSGPMAQRLLSAHRLKPRAGET LEERRKAIQSAVSETSSNHLLLNISTQAALAGAVTMLRILPDKLNPVVKP LMESVKREDNEQLQELAAEHLARLVELCVERNPCPNAKIVSNLCTFLCCD HEYTPKI------------------------------------------- -------------------------------------------------- -----QFxAG---------------------------------EGDSGVE STGDNSRTGTPTGYNADNYTGILTLTNQQRSAERAVLRRSNSTGGRGPGR PPLTDIPLEELFAVEDSMAKLNKIQRRGAAFALTAIAAHFASNLHCRLPK LWEVMIVQLSEAVDFATFDPTLLVNNDQGAEDLVSSLQVLEVTCPALHSD LLGQ---------------------------------------------- -------------------------------------------------- --------------------------------VLQYLPRMCLLLTHPYRA VRHMAARCLGALAALSSVPVMTHVVDQVLPLLGTIDSDINRQGAVEALAC IIEHLKFGVVPYIVLLVVPLLGRMSDQNQPVRLMATHCFATLIQLMPLDG GVPDPPNLTSQLAQHKARERRFLEQLFNPKSIENYKVPVSIRAELRCYQQ SGVNWLAFLNKYKLHGILCDDMGLGKTLQSICILAGDHFYRHQHYLKTRS PDCVPLPSIVICPPTLTGHWVYEVNKFLPEQFLYPLQYVGPPAERDKMRS LVGKHNLVVASYDIVRKDIDFFSSIKWNYCILDEGHVIKNGKTKSSKAIK QLTANHRLILSGTPIQNNVLELWSLFDFLMPGFLGTEKQFTARYSKPILA SRDAKSSPKEQEAGALAMEALHRQVLPFLLRRMKEDVLQDLPPKITQDYY CELSPLQERLYEDFARSHAH-------------------------QSLQE SLSGRx----------------------xxxxxxxNTHIFQALRYLQNVC NHPKLALTPQHPEYERVSGQLHQENSSLADINHAAKLPALRQLLLDCGIG VPLTEHPGELVINQHRALIFCQLKAMLDIIENDLFKRHMATVSYLRLDGS IPPSMRHSVVAQFNSDPSIDVLLLTTQVGGLGLNLTGADTVIFVEHDWNP MKDLQAMDRAHRIGQRKVVNVYRLITRGTLEEKIMGLQKFKLMTANTVIS SENASMETMGTDxSQLP------------xSALGNHSSPLFQLxxxxxxx xxKGTGGRQAVGSGQGMRSVLDTLPDLWEDKQYEEEYDLSNFIHNLRH-- - >Tte MxxxxxPxxxDLHPVS----xYPNRATTHHCNS----------------- -------------------------------------------------- -------------------------------------------------- -------VLSRLDRLFVLLETGSSPVTRRAAAQQLGEVQRLHPHELHNLL SRITTYLHSPSWETRIAAGQAVEAVLRHVPQWDPVGSPVKTxxxxxxxxx xxxxxxxxxxxxxxxxxxxxxDMxxxxxxxxxx---xxxxxxxxxxxxxx x------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -----RPVSEVVLQEGGLSSREMNRARRKARQAVLKQRSREGGG-AGEET GVGDEPDKKRVKTEDSKAFVEGTAAGYGDSVPDSTGSW----GEAxEWPF ESFCDRLCQDLFSLSWEVRHGAATALREVIRLHGAGAGKSANIPKTE--- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ------------------xxxxxxxxxxxxxxVTLYxxxxxQRxxxxxxx xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx xxxxxxxxxxxx---------------------------xxxxxxxxxxx xxQRGTQFTLYxAVTGQRGTQFTLYTAVTGQRGTQxxxYTAxxxxRGTQF TxxxAVTGQRGTQFTLYTAVTGQRGTQFTLYTxxxGQRGTQxxLYTAVTG QRGTQFTLYTAVTGQRGTQVTLYTAITGQxxxxxxLYxxVTGQRGTQFTL YQGxxxxHQLWLEDIALRLLCVLALDRFGDFVSDQVVAxxxxxCAQxx-- ---------------------------------xxxLxxxxxxxxDGVLR VLVQLLNQREWEARHGGLLGLKYLLAVREDLVRQLLPAAFPHILEGLSDP VDDVGAVAASALIPVAPNVVTELPGQVEATVQRLWDLLLDQDELAAACNS FMGLLAALLSLPDxxxxxx------------------------------- RQPLCEVVPRLWPFLSHSTSSVRRATLQTLxxxxxxESAxxxxxxxxxxx xPLLxxxxxxIFQRTLVEPxTEIQDLAEKVWGNLIRYSSLQELLLASCPF VSTWLCLTMQPAKLAIDPALLVHxxxxxx--------------------- ----------ERSGERLTRRPxAFxPLESNCGNxGGVEGGIAGAGAGLKC EQKLYLGGxxxxxLAT----xxxNVMRARCMASRMxxxxxCYIVQPAPGI VYTPDVESPVDSYVKVLLVYLNSKSALQRMVVGLVIAEWARLDTLTTACP ETLK---------------------------------------------- -------------------------------------------------- -------------------CRLHQCLSECVYFDEIAVSFTKLLQEAKDFV AMLKHYKLPLDCAGYDGTSVLTLDQIQQLSGPMAQRLLSAHRLKPRAAET LEERRKAIQSAVSETSSNHLLLNISTQAALAGAVTMLRILPDKLNPVVKP LMESVKREDNEQLQELAAEHLARLVELCVERSPCPNAKIVSNLCTFLCCD HEYTPKIx------------------------------------------ -----------------------------------------xxxxxAIHD GFVCPQFAAG---------------------------------EGDSGVE STGDNSRTGTPTGFNTDNYTGILTLTNQQRSAERAVLRRSNSTGGRGPGR PPLTDIPLEELFAIEDSTAKLNKIQRRGAAFALTAIAAHFASNLHSRLPK LWEVMIVQLSEAVDFATFDPSLLVNNDQGAEDLVSSLQVLEVTCPALHSD LLGQ---------------------------------------------- -------------------------------------------------- --------------------------------VLKYLPRLCLLLTHPYRA VRHMAARCLGALAALSSVPVMTHVVDQVLPLLGTIDSDINRQGAVEALAC IVEHLKLRVVPYIVLLVVPLLGRMSDQNQPVRLMATHCFATLIQLMPLDG GVPDPPNLTSQLAQHKARERRFLEQLFNPKSIENYKVPVSIRAELRCYQQ SGVNWLAFLNKYKLHGILCDDMGLGKTLQSICILAGDHFYRHQHYLKTRS PDCVPLPSIVICPPTLTGHWVYEVNKFLPDQFLYPLQYVGPPAERDKMRS LVGKHNLVVASYDIVRKDIDFFSSIKWNYCILDEGHVIKNGKTKSSKAIK QLTANHRLILSGTPIQNNVLELWSLFDFLMPGFLGTEKQFTARYSKPILA SRDAKSSPKEQEAGALAMEALHRQVLPFLLRRMKEDVLQDLPPKITQDYY CELSPLQERLYEDFARSHAH-------------------------QSLQE SLSGRx----------------------xxxxxxxNTHIFQALRYLQNVC NHPKLALTPQHPEYERVSGQLHQENSSLADINHAAKLPALRQLLLDCGIG VPLTEHPGELVINQHRALIFCQLKAMLDIIENDLFKRHMATVSYLRLDGS IPPGMRHSVVAQFNSDPSIDVLLLTTQVGGLGLNLTGADTVIFVEHDWNP MKDLQAMDRAHRIGQRKVVNVYRLITRGTLEEKIMGLQKFKLMTANTVIS SENASMETMGTD-----------------------------QLLDLFSLE D-KGAAGRQAVGSGQGMKSVLDTLPDLWEDKQYEEEYDLSNFIHNLRH-- - >Tce -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -----------------------------------------------xxx xxxxxxxxxxxxxx--------xxxxxxxLRxxxxxxxxxxxxxxDGVLS VLVQLLNQREWEARHGGLLGLKYLLAVREDLVRQLLPAAFPHILEGLSDP VDDVGAVAASALIPVAPNVVTELPGQVExxVQRLWDLLLDQxELAAACNS FMGLLAALLSLPDxxxxxx------------------------------- RQPLCEVVPRLWPFLSHSTSxxxxxxxxxxxxxxxxExxxxxxxxxxxxx xxxxxxxxxxIFQRTLVEPxTEIQDLAEKVWGNLIRYSSLQELLLASCPF VSTWLCLTMQPAKLVIDPALLIHxxxxxx--------------------- ----------ERFGERSTRxxxAFxSLESNCxxxGGVEGGITGAGAGLKC EQKLYLGGxxxxxLAT----xxxNVMRARCMASRMxxxxxxxxxxxxxGI VYSPDVESPVDSFVKVLLVYLNSKSALQRMVVGLVIAEWARLDTLTPACP ETLK---------------------------------------------- -------------------------------------------------- -------------------CRLHQCLSECVYFDEIAVSFTKLLQEAKDFV AMLKHYKLPLDCAGYDGTSVLTLDQIQQLSGPMAQRLLSAHRLKPRAGET LEERRKAIQSAVSETSSNHLLLNISTQAALAGAVTMLRILPDKLNPVVKP LMESVKREDNEQLQELAAEHLARLVELCVDRNPCPNAKIVSNLCTFLCCD HEYTPKI------------------------------------------- -------------------------------------------------- -----QFAAGKWxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx------- ------RTGTPTGFNTDNYTGILTLTNQQRSAERAVLRRSNSTGGRGPGR PPLTDIPLEELFAVEDSMAKLNKIQRRGAAFALTAITAHFASNLHRRLPK LWEVMIVQLSETVDFATFDPSLLVNNDQGAEDLVSSLQVLEATCPALHSD LLGQxQNYVSINCLGERAENYSQYTQLGLDPDPSVIGS------------ -------------------------------------------------- -------------------------------xVLQYLPRMCLLLTHPYRA VRHMAARCLGALAALSSVPVMTHVVDQVLPLLGTIDSDINRQGAVEALAC IIEHLKFGVVPYIVLLVVPLLGRMSDQNQPVRLMATHCFATLIQLMPLDG GVPDPPNLTSQLAQHKARERRFLEQLFNPKSIENYKVPVSIRAELRCYQQ SGVNWLAFLNKYKLHGILCDDMGLGKTLQSICILAGDHFYRHQHYLKTRS PDCVPLPSIVICPPTLTGHWVYEVNKFLPEQFLYPLQYVGPPAERDKMRS LVGQHNLVVASYDIVRKDIDFFSSIKWNYCILDEGHVIKNGKTKSSKAIK QLTANHRLILSGTPIQNNVLELWSLFDFLMPGFLGTEKQFTARYSKPILA SRDAKSSPKEQEAGALAMEALHRQVLPFLLRRMKEDVLQDLPPKITQDYY CELSPLQERLYEDFARSHAH-------------------------QSLQE SLSGRx----------------------xxxxxxxxTHIFQALRYLQNVC NHPKLALTPQHPEYERVSGQLHQENSSLADINHAAKLPALRQLLLDCGIG GPLTEHPGELVINQHRALIFCQLKAMLDIIENDLFKRHMATVSYLRLDGS IPPSMRHSVVAQFNSDPSIDVLLLTTQVGGLGLNLTGADTVIFVEHDWNP MKDLQAMDRAHRIGQRKVVNVYRLITRGTLEEKIMGLQKFKLMTANTVIS SENASMETMGTD-----------------------------QLxxxxxxx xxKGTGGRQAVGSGQGMRSVLDTLPDLWEDKQYEEEYDLSNFIHNLRH-- - >Tdi --------------------------------xGDITLYKLNMYIFEYKx xxxxxxxxxxxKSSSRQHEGVPSDNVAIEEVLxxxEGRSPVPKLSGTNRH CWKLALQLVAFTTKRFxxxxxExxxxxxxxxxxxxxxxxxxxxxxxxxxx xxxxxxxVLSRLDRLFVLLETGSSPVTRRAAAQQLGEVQKLHPHELHNLL SRITTYLHSPSWETRIAAGQAVEAVLRHVPQWDPVGSPVKT--------- -------------------------------------------------- ESYSASVALSQVGRMNFQKFSMSNVLANSSHLMGSEGKEFDMEEDVA--- -------------------------------------------------- -------------------------------------------------- -------------------xATLxxxLMRQxGxxxxxxxxxxxxxxxxxx xxxxxRPVSEVVLQEGGLSSREMNRARRKARQAVLKQRSREGGG-AGEET GGAEEPDKKRVKTEDSKAFVEGTSAGYGDSVPDSTGSW----GEAxEWPF ESFCDRLCQDLFSLSWEVRHGAATALREVIRLHGAGAGKSANIPKTE--- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ------------------x----------------------------xxx xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx---------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------xx----------------------------- -------------------------xxxxxxxxxxxLxxxxxxxxDGVLR VLVQLLNQREWEARHGGLLGLKYLLAVREDLVRQLLPAAFPHILEGLSDP VDDVGAVAASALIPVAPNVVTELPGQVEATVQRLWDLLLDQDELAAACNS FMGLLAALLSLPDxxxxxx------------------------------- RQPLCEVVPRLWPFLSHSTSSVRRATLQTLxxxxxxESAxxxxxxxxxxx xPLLxxxxxxIFQRTLVEPxTEIQDLAEKVWGNLIRYSSLQELLLASCPF VSTWLCLTMQPAKLVIDPALLIHxxxxxx--------------------- ----------ERSGERSTRRPxAFxSLESNCGNxGGAEGGITGAGAGLKC EQKLYLGGxxxxxLAT----xxxNVMKARCMASRMxxxxxCYIVQPAPGI VYSPDVESPVDSFVKVLLVYLNSKSALQRMVVGLVIAEWARLDTLTPACP ETLK---------------------------------------------- -------------------------------------------------- -------------------CRLHQCLSECVYFDEIAVSFTKLLQEAKDFV AMLKHYKLPLDCAGYDGTSVLTLDQIQQLSGPMAQRLLSAHRLKPRAGET LEERRKAIQSAVSETSSNHLLLNISTQAALAGAVTMLRILPDKLNPVVKP LMESVKREDNEQLQELAAEHLARLVELCVERNPCPNAKIVSNLCTFLCCD HEYTPKIxxxxxxxxxxxxxxxx----------------xxxxxxxEVES TVAISDxxVxx------------------------SVCRQEVESKVDISD MFVCPQFAAG---------------------------------EGDSGVE STGDNSRTGTPTGYNADNYTGILTLTNQQRSAERAVLRRSNSTGGRGPGR PPLTDIPLEELFAVEDSMAKLNKIQRRGAAFALTAIAAHFASNLHRRLPK LWEVMIVQLSEAVDFATFDPTLLVNNDQGAEDLVSSLQVLEVTCPALHSD LLGQ---------------------------------------------- -------------------------------------------------- --------------------------------VLQYLPRMCLLLTHPYRA VRHMAARCLGALAALSSVPVMTHVVDQVLPLLGTIDSDINRQGAVEALAC IIEHLKFGVVPYIVLLVVPLLGRMSDQNQPVRLMATHCFATLIQLMPLDG GVPDPPNLTSQLAQHKARERRFLEQLFNPKSIENYKVPVSIRAELRCYQQ SGVNWLAFLNKYKLHGILCDDMGLGKTLQSICILAGDHFYRHQHYLKTRS PDCVPLPSIVICPPTLTGHWVYEVNKFLPEQFLYPLQYVGPPAERDKMRS LVGKHNLVVASYDIVRKDIDFFSSIKWNYCILDEGHVIKNGKTKSSKAIK QLTANHRLILSGTPIQNNVLELWSLFDFLMPGFLGTEKQFTARYSKPILA SRDAKSSPKEQEAGALAMEALHRQVLPFLLRRMKEDVLQDLPPKITQDYY CELSPLQERLYEDFARSHAH-------------------------QSLQE SLSGRx----------------------xxxxxxxNTHIFQALRYLQNVC NHPKLALTPQHPEYERVSGQLRQENSSLADINHAAKLPALRQLLLDCGIG VPLTEHPGELVINQHRALIFCQLKAMLDIIENDLFKRHMATVSYLRLDGS IPPSMRHSVVAQFNSDPSIDVLLLTTQVGGLGLNLTGADTVIFVEHDWNP MKDLQAMDRAHRIGQRKVVNVYRLITRGTLEEKIMGLQKFKLMTANTVIS SENASMETMGTD-----------------------------QV------- -----------------------------------------------xxx x >Tcm -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ----------------------MNRARRKARQAVLKQRSREGGG-AGEET GGAEEPDKKRVKTEDSKAFVEGTSAGYGDSVPDSTGSW----GEAxEWPF ESFCDRLCQDLFSLSWEVRHGAATALREVIRLHGAGAGKSANIPKTExxx xxxxxxSLxxxxxxxxFTLLSLxxxxxxxxxxxxxxxxxxxx------xx xxxxxxxREEHxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxPSLDR EEHSSHFTLPSLxxxxxSSHxxxxxxxxxxxxSHFTLLSLDKEEHSSHFT LLSLDKEEHSSHxxLPSLDREEHSSHFTLPSLDREEHSSHFTLPSLDREE xxxxxxLxxxDREEHSSHFTLYTA-------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ---xxxxHQxxxEDIALRLLCVxxxDRFGxxxSDQVxxxxxETxxQAL-- -------------xxxxxxxxxxxxxxxxLRxxxxxLxxxxxxxxDGVLR VLVQLLNQREWEARHGGLLGLKYLLAVREDLVRQLLPAAFPHILEGLSDP VDDVGAVAASALIPVAPNVVAELPGQVExxVQRLWDLLLDQDELAAACNS FMGLLAALLSLPDxxxxxx------------------------------- RQPLCEVVPRLWPFLSHSTSSVRRATLQTLxxxxxxESAxxxxxxxxxxx xPLLxxxxxxIFQRTLVEPxTEIQDLAEK--------------------- -------------------------------------------------- ----------ERSGERSTRRPxAFxSLESNCGNxAGAEGGITGAGAGLKC EQKLYLGGxxxxxLAT----xxxNVMKARCMASRMxxxxxxxIVQPAPGI VYSPDVESPVDSFVKVLLVYLNSKSALQRMVVGLVIAEWARLDTLTPACP ETLK---------------------------------------------- -------------------------------------------------- -------------------CRLHQCLSECVYFDEIAVSFTKLLQEAKDFV AMLKHYKLPLDCAGYDGTSVLTLDQIQQLSGPMAQRLLSAHRLKPRAGET LEERRKAIQSAVSETSSNHLLLNISTQAALAGAVTMLRILPDKLNPVVKP LMESVKREDNEQLQELAAEHLARLVELCVERNPCPNAKIVSNLCTFLCCD H---------------------xxxxxxxxxxxxxxxxxxxxVCRQEVxx xxx--------------------------------------------TSD MFVCPQFAAG---------------------------------EGDSGVE STGDNSRTGTPTGYNADNYTGILTLTNQQRSAERAVLRRSNSTGGRGPGR PPLTDIPLEELFAVEDSMAKLNKIQRRGAAFALTAIAAHFASNLHRRLPK LWEVMIVQLSEAVDFATFDPTLLVNNDQGAEDLVSSLQVLEVTCPALHSD LLGQ---------------------------------------------- -------------------------------------------------- --------------------------------VLQYLPRMCLLLTHPYRA VRHMAARCLGALAALSSVPVMTHVVDQVLPLLGTIDSDINRQGAVEALAC IIEHLKFGVVPYIVLLVVPLLGRMSDQNQPVRLMATHCFATLIQLMPLDG GVPDPPNLTSQLAQHKARERRFLEQLFNPKSIENYKVPVSIRAELRCYQQ SGVNWLAFLNKYKLHGILCDDMGLGKTLQSICILAGDHFYRHQHYLKTRS PDCVPLPSIVICPPTLTGHWVYEVNKFLPEQFLYPLQYVGPPAERDKMRS LVGKHNLVVASYDIVRKDIDFFSSIKWNYCILDEGHVIKNGKTKSSKAIK QLTANHRLILSGTPIQNNVLELWSLFDFLMPGFLGTEKQFTARYSKPILA SRDAKSSPKEQEAGALAMEALHRQVLPFLLRRMKEDVLQDLPPKITQDYY CELSPLQERLYEDFARSHAHxxxxxxxxxxxxxxxxxxxxxxxxxxx--- -----------------------------------------ALRYLQNVC NHPKLALTPQHPEYERVSGQLRQENSSLADINHAAKLPALRQLLLDCGIG VPLTEHPGELVINQHRALIFCQLKAMLDIIENDLFKRHMATVSYLRLDGS IPPSMRHSVVAQFNSDPSIDVLLLTTQVGGLGLNLTGADTVIFVEHDWNP MKDLQAMDRAHRIGQRKVVNVYRLITRGTLEEKIMG-------------- -------------------------------------------------- ------------------SVLDTLPDLWEDKQYEEEYDLSNFIHNLRH-- - >Tbi MEGVGYPRTGDLHPVx----xxPNRATTHHCNS----------------- -------------------------------------------------- -------------------------------------------------- -------VLSRLDRLFVLLETGSSPVTRRAAAQQLGEVQRLHPHELHNLL SRITTYLHSPSWETRIAAGQAVEAVLRHVPQWDPVGSPVKT--------- -------------------------------------------------- ESYSASVALSQVGRMNFQKFSMSNVLANSSHLMGSEGKEFDTEEDVA--- -------------------------------------------------- -------------GVDIREKMARQRQQLNARLGLDTAARIGLDDMSDIFE AEDxxxxxEFxRSRSVEAAR------------------------------ -----RPVSEVVLQEGGLSSREMNRARRKARQAVLKQRSREGGG-AGEET GVGDEPDKKRVKTEDSKAFVEGTAAGYGDSVPDSTGSW----G---EWPF ESFCDRLCQDLFSLSWEVRHGAATALREVIRLHGAGAGKSANIPKTE--- -----------------------------------------xxxxxxxxx xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx xxx------------------------xxxxxxxxxxxxxDREEHCxxxx xxxxxxxxx----------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ------------------------------------------------GI VYTPDVESPVDSYVKVLLVYLNSKSALQRMVVGLVIAEWARLDTLTTACP ETLK---------------------------------------------- -------------------------------------------------- -------------------CRLHQCLSECVYFDEIAVSFTKLLQEAKDFV AMLKHYKLPLDCAGYDGTSVLTLDQIQQLSGPMAQRLLSAHRLKPRAAET LEERRKAIQSAVSETSSNHLLLNISTQAALAGAVTMLRILPDKLNPVVKP LMESVKREDNEQLQELAAEHLARLVELCVERSPCPNAKIVSNLCTFLCCD HEYTPKI------------------------------------------- -------------------------------------------------- -----QFAAG---------------------------------EGDSGVE STGDNSRTGTPTGFNTDNYTGILTLTNQQRSAERAVLRRSNSTGGRGPGR PPLTDIPLEELFAIEDSTAKLNKIQRRGAAFALTAIAAHFASNLHSRLPK LWEVMIVQLSEAVDFATFDPSLLVNNDQGAEDLVSSLQVLEVTCPALHSD LLG----------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------Q SGVNWLAFLNKYKLHGILCDDMGLGKTLQSICILAGDHFYRHQHYLKTRS PDCVPLPSIVICPPTLTGHWVYEVNKFLPDQFLYPLQYVGPPAERDKMRS LVGKHNLVVASYDIVRKDIDFFSSIKWNYCILDEGHVIKNGKTKSSKAIK QLTANHRLILSGTPIQNNVLELWSLFDFLMPGFLGTEKQFTARYSKPILA SRDAKSSPKEQEAGALAMEALHRQVLPFLLRRMKEDVLQDLPPKITQDYY CELSPLQERLYEDFARSHAH-------------------------QSLQE SLSGRxxxxxxxxxxxxxxTxxxxxxxxx-----------EALRYLQNVC NHPKLALTPQHPEYERVSGQLHQENSSLADINHAAKLPALRQLLLDCGIG VPLTEHPGELVINQHRALIFCQLKAMLDIIENDLFKRHMATVSYLRLDGS IPPGMRHSVVAQFNSDPSIDVLLLTTQVGGLGLNLTGADTVIFVEHDWNP MKDLQAMDRAHRIGQRKVVNVYRLITRGTLEEKIMGLQKFKLMTANTVIS SENASMETMGTD-----------------------------QLLDLFSLE x-KGAAGRQAVGSGQGMKSVLDTLPDLWEDKQYEEEYDLSNFIHNLRH-- - >Tps xxxx---------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------xxxxxLAPS---------- -------------------------------------------------- -------------------------------------------------- -------------GVDIREKxxxxxxxxxxxxxxxxxxxx---------- -------------------------------------------------- ----------VVLQEGGLSSREMNRARRKARQAVLKQRSREGGG-AGEET GGAEEPDKKRVKTEDSKAFVEGTSAGYGDSVPDSTGSWxWSCVEAxEWPF ESFCDRLCQDLFSLSWEVRHGAATALREVIRLHGAGAGKSANIPKTE--- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ---xxxxHQLWLEDIALRLLCVLALDRFGDFVSDQVVAPVRETCAQxx-- ---------------------------------xxxLxxxxxxxxDGVLR VLVQLLNQREWEARHGGLLGLKYLLAVREDLVRQLLPVAFPHILEGLSDP VDDVGAVAASALIPVAPNVVTELPGQVEATVQRLWDLLLDQDELAAACNS FMGLLAALLSLPDxxxxxx------------------------------- RQPLCEVVPRLWPFLSHSTSSVRRATLQTLxxxxxxESAxxxxxxxxxxx xPLLxxxxxxIFQRTLVEPxTEIQDLAEKVWGNLIRYSSLQELLLASCPF VSTWLCLTMQPAKLVIDPALLIHxxxxxxVSLIENIVNDDLDGTGNTRVS RHCFLVRSFxERSGERSTRRPxAFxSLESNCGNxGGAEGGITGAGAGLKC EQKLYLGGxxxxxLATxxxxx----------------xxxCYIVQPAPGI VYSPDVESPVDSFVKVLLVYLNSKSALQRMVVGLVIAEWARLDTLTPACP ENLKSQAIWxxxxxLLKKGVASTQTMSEGxxxxxITPSAMVFSEGSTAGL MCEGEQNCLxxxxxxxxx-------------------------------x xxxxxxxxGPSAVIFATNxCRLHQCLSECVYFDEIAVSFTKLLQEAKDFV AMLKHYKLPLDCAGYDGTSVLTLDQIQQLSGPMAQRLLSAHRLKPRAGET LEERRKAIQSAVSETSSNHLLLNISTQAALAGAVTMLRILPDKLNPVVKP LMESVKREDNEQLQELAAEHLARLVELCVERNPCPNAKIVSNLCTFLCCD HEYTPKIx--------------------------------------xxES TVAIHDVFVCPxFxVRRWxxxxxxxxxxxxRSLxxGVCRQEVESTVAISD MLVCPQFAAG---------------------------------EGDSGVE STGDNSRTGTPTGFNVDNYTGILTLTNQQRSAERAVLRRSNSTGGRGPGR PPLTDIPLEELFAVEDSMAKLNKIQRRGAAFALTAIAAHFASNLHRRLPK LWEVMIVQLSEAVDFATFDPSLLVNNDQGAEDLVSSLQVLEVTCPALHSD LLGQ---------------------------------------------- -------------------------------------------------- --------------------------------VLQYLPRMCLLLTHPYRA VRHMAARCLGALAALSSVPVMTHVVDQVLPLLGTIDSDINRQGAVEALAC IIEHLKFGVVPYIVLLVVPLLGRMSDQNQPVRLMATHCFATLIQLMPLDG GVPDPPNLTSQLAQHKARERRFLEQLFNPKSIENYKVPVSIRAELRCYQQ SGVNWLAFLNKYKLHGILCDDMGLGKTLQSICILAGDHFYRHQHYLKTRS PDCVPLPSIVICPPTLTGHWVYEVNKFLPEQFLYPLQYVGPPAERDKMRS LVGKHNLVVASYDIVRKDIDFFSSIKWNYCILDEGHVIKNGKTKSSKAIK QLTANHRLILSGTPIQNNVLELWSLFDFLMPGFLGTEKQFTARYSKPILA SRDAKSSPKEQEAGALAMEALHRQVLPFLLRRMKEDVLQDLPPKITQDYY CELSPLQERLYEDFARSHAH-------------------------QSLQE SLSGRx----------------------xxxxxxxNTHIFQALRYLQNVC NHPKLALTPQHPEYERVSGQLRQENSSLADINHAAKLPALRQLLLDCGIG VPLTEHPGELVINQHRALIFCQLKAMLDIIENDLFKRHMATVSYLRLDGS IPPSMRHSVVAQFNSDPSIDVLLLTTQVGGLGLNLTGADTV--------- -------------------------------------------------- -------------xxxxxxxxxxxxxxxxx-------------------- -------------------------------------------------- -