>Tge --------------------x----------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- --------xxxELPSILEKDDGFSSDRGSKSSSGTEDHYEEELYALAHFS DPNKTNPNSDVIEESQHTVDSNTTYQPSRWNKVMRLQGAQIIENADNPDD SITRRVSIFDSSSPAENYIPLGQNNHNTERNRERMKRPNRGDKYSKTRKQ RRSLPELDGGDAASDRFSGNYNTDPINYPFSTNNKYFDNLRVKSSKKNYS NQLGLENQRNISPISPTHKSRKVNGVNVNINSSNYPAKTADKHNQSLTSE VSIANRNKTDQDLNKTPVASIPGINQDNQSENASL--DAILDETLNADQD ISSKQSSTSNSLVINQNQSSKSLNSLQNTNLNTCGDNTALISISSDESSD SAMSFLVDTDDSTSSSISRRSPSVEIIVLSK------xxxxxxxxxELII LECSDIEKEEYSDVEILTPPVKTPPPLVTLESDEEAQIQQGSQVN-SPKS TNTSKD-NKNKKQNQQNSSNNSVNISTSSGGGNKPLDDDNNANADVLILP ETGNESQDDFL--SSDSNSDDRLVIDLGLNTTGEASKVVSDVSNVEVTVK ERQTEHMRKKIRKKKEKRSNALKNVEEDKLFIESNEHFNHTVLQDQMSND IALWRVEPSDYATSTKSRLSKLRCHNCKELGHIVSRCTAPTKKILCIMCG QEGHTYTRCRDIICL----------------------------------- -------------------------------------------------- ---------------------------------------------xCGEP WTSWSTIGCDHCRTINVQCYFCRSMDHFKNACPEVWRRYHSTIEDYIEQF DPPPASYKPNSELSCPN------------CTRKGHMFEDCKVSIPFKNHR LGSFNSLGIYDRRAEQETDIYYSRSVTHNKRHSPPEKVNSFVDLSRNLPI -------PSTSRDPP----DPSEVLQIVLKKGMRQPKTRTRNNRKKRARQ TMQFEETKINKHLKIMRKKELAKKRLAKKNIKMKQIFARNMKKTTGPLW >Tpa -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ------------------------------LNTCGDNTALISISSDESSD SAMSFLVDTDDSTSSSTSRRSPSVEIIVLSK------xxxxxxxxxELII LECSDIEKEEYSDVEILTPPVKTPPPLVTLESDEEAQIQQGSQVN-SPKS TNTSKD-NKNKKQNQQNSSNNSVNISTSSGGGNKPLDDDNNANADVLILP ETGNESQDDFL--SSDSNSDDRLVIDLGLNTTGGAEKVVSNVSNVEVTVK ERQTERMRKKIRKKKEKRSNALKNVEEEKLFIESNEHFNHTVLQDQMSND IALWRVEPSDYATSTKSRLSKLRCHNCKELGHIVSRCTAPTKKILCIMCG QEGHTYTRCRDIICL----------------------------------- -------------------------------------------------- ---------------------------------------------xCGEP WTSWSTIGCDHCRTINVQCYFCRSMDHFKNACPEVWRRYHSTIEDYIEQF DPPPASYKPNSELSCPN------------CTRKGHMFEDCKVSIPFKNHR LGSFNSLGIYDRRAGPETDIYYSRSVTHNKRHSPPEKVNSFVDLSRNLPI -------PSTSRDPP----DPSEVLQIVLKKGMRQPKTRTRNNRKKRARQ TMQIEETKINKHLKIMRKKELAKKRLAKKNIKMKQIFARNMKKTTGPLW >Tbi --------------------xxxxxESFEQFEEEESEAPLGATLSGRKRL FSKELRCMMFGFGDDQNPxTESVDLIEDxxxEFITEMTxxxxxxxRTGRV QVEDIVFLVRKDQRKYARVKDLLTMNEELKKARKAFDEVKYAG------- -------------------------------------------------- -------------------------------------------------- ------------LLLKPPGSLVSCLWxxSAxxxxxxxxxxxSFLxxxxxx xxxxxxxxxxxQLPSILEKEDGFSSDRGSKSSSGTEDHYEEELYALAHFS DPNKTNPNSDVIEESQHTVDSNTTYQPSRWNKVMRLQGAQIIENADNPDD SITRRVSTFDSSSPAENYIPLGQNNYNTERNRERMRRPNRGDKYSKTRKQ RRSLPDLDGGDAASDRFSGNYNTDPINYPFSTNNKYSDNLRVKSSKKNYS NQLGLENQRNISPTSPTHKSRKVNRVNVNINSSNYPAKTADEHNQSLTSE VSIANRNKTDQDLNKTPVASIPGVNQDNQSENASL--DAILDETLNADQD ISSKQSPTSNSLVINQNQSSKSLNSLQNTNLNTCGDNTALISISSDESSD SAMSFLVDTDDSTSSSRSRRSPSVEIIVLSKSDSDxxxDSDSxxxxELII LECSDIEKEEYSDVEILTPPVKTPPPLVTLESDEEAQIQQGSQVN-SPKS TNTSKD-IKNKKQNQQNSSNNSVNVSTSSGGGNKPLDDDNNANADVLILP ETGNESQDDFL--SSDSNSDDRLVIDLGLNTTVVAEKVVSDVSNVEVTVK ERQTERMRKKIRKKKEKRSNALKNVEEDKLFIESNEHFNHTVLQDQMSND IALWRVEPSDYATSTKSRLSKLRCHNCKELGHIVSRCTAPTKKILCIMCG QEGHTYTRCRDIICLKAGxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx xxxx---------------------------------------------- ---------------------------------------------KCGEP WTSWSTIGCDHCRTINVQCYFCRSMDHFKNVCPEVWRRYHSTIEDYIEQF DPPPASYKPNSELSCPN------------CTRKGHMFEDCKMSIPFKNHR LGSFNSLGIYDRRAEQETDVYYSRSVTHNKRHSPPEKVNSFVDLSRNLPI -------PSTSRDPPDTSFDPSEVLQIVLKKGMRQPKTRTRNNRRKRARQ TMQFEETKINKHLKIMRKKELAKKRLAKKNIKMKQIFARNMKKTTGPLW >Tte --------------------MxxADESFEQFEEEESEAPLGATLSGRKRL FSKELRCMMFGFGDDQNPYTESVDLIEDLVIEFITEMTHKAMEIGRTGRV QVEDIVFLVRKDQRKYARVKDLLTMNEELKKARKAFDEVKYAGKxxxxxx xxxxxxKVFSAGSPLxRIxLxPxSxxxxSKLxDD---------------- ---------xIQPPKRxxxxASWxxxxxxxxxxCERVFWELPRYEQFSxx xxxxxxxxxxxxx------------------------------------- -----------KLPSILEKEDGFSSDRGSKSSSGTEDHYEEELYALAHFS DPNKTNPNSDVIEESQHTVDSNTTYQPSRWNKVMRLQGAQIIENADNPDD SITRRVSTFDSSSPAENYIPLGQNNHNTERNRERMRRPNRVDKYSKTRKQ RRSLPELDGGDAASDRxx-------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ------VDTDDSTSSSRSRRSPSVEIIVLSKSDSDxxxDSDSExxxELII LECSDIEKEEYSDVEILTPPVKTPPPLVTLESDEEAQIQQGSQVN-SPKS TNTSKD-IKNKKQNQQNSSNNSVNVSTSSGGGNKPL-xDNNANADVLILP ETGNESQDDFL--SSDSNSDDRLVIDLGLNTTVVAEKVVSDVSNVEVTVK ERQTERMRKKIRKKKEKRSNALKNVEEDKLFIESNEHFNHTVLQDQMSND IALWRVEPSDYATSTKSRLSKLRCHNCKELGHIVSRCTAPTKKILCIMCG QEGHTYTRCRDIICLKAGxxxLQNNRExxxxxxxxxxxxGxxxxxxIKYS Dxxx---------------------------------------------- ---------------------------------------------KCGEP WTSWSTIGCDHCRTINVQCYFCRSMDHFKNVCPEVWRRYHSTIEDYIEQF DPPPASYKPNSELSCPN------------CTRKGHMFEDCKMSIPFKNHR LGSFNSLGIYDRRAEQETDVYYSRSVTHNKRHSPPEKVNSFVDLSRNLPI -------PSTSRDPPDTSFDPSEVLQIVLKKGMRQPKTRTRNNRRKRARQ TMQFEETKINKHLKIMRKKELAKKRLAKKNIKMKQIFARNMKKTTGPLW >Tsi --------------------x----------------------------- -------------------------------------------------- -------------------------------------------------- --------------------------------xx---------------- ---------x---------------------------------------- -------------------------------------------------- -----------EPPSILEKDDGFSSDSGSKSSSGTEDYYEEQLYALAHFS DPNKTNPNSDAIEVLQNTVDPNTPYQPSRWNKVMRLQGAQIIENADNPDN SITKRVSTFDSSSPAENYIPLGLNNYNAEQSRERIRRPNRGNRYSKTRKP RGSLPEFDGGHAASDRSSGNYNTDPINYPFSTNNKYSNHLRVKSSKKNNS NQLGLENQGNISTPSPTHESLKVNGVNVNVYSSNHPTETVAERNQSLTSE VSIADRNETDQDLNKASSAPILSVDQNDQSENASLYKDAILDESVNADQD ISSKQLSTSDSLVINQNQSSKSVNSLQNTNLNTCGDDTVLISISSDESSD SAMSFIVDSDDTTSSSRSRRSSSVEIIILSKSDSE--xxx------ELIV LECSDIEKVEYSDVEILTPPVKTPPPLVTLESDEETQLQQDNQVIxSPKS TNTSKDxIKNKKQNQQNSSNSSVNISTSSVGGHIPLNGDKNANADVQILP ETSDESQDDFLx-SSDSNSNDRLVIDMDLNPSGQPEKVVSNVNNVAVTVK ERQTERLRKKIRKKKEKRSNALTNVEEERLFIEANEHFNHTVLQDQMSND IALWRVQPSDYATSTKSRFSKLRCHNCKELGHVVSRCTAPTKKTLCIMCG RQGHTYTRCRDIICLK---------------------------------- -------------------------------------------------- ----------------------------------------------CGEP WTSWSTVGCDQCRTIKVQCHFCRSMDHLKNACPEVWRRYHSTVEDYIEQF DPPPAHYKPNSELSCPN------------CTKKGHKFEDCKMSIPIKKHR PDSFNGHGIYDRHTEQETDIYYSRGLTHHKRYSLPEKVNSFVDLSRHLPA -------PSTSREPPGASVDPSEVLQMVLNKGMRQPKSRTRNNRKKRARQ TMQFEETRINKQLKIMRKKDLAKKRLAKKNLKMKQIFARNINNTSGPHW >Tcm xxxxxxxxxxxxxxxxxxxx------------------------------ -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ------------PPSILEKDDGFSSDSGSKSSSGTEDYYEEQLYALAHFS DPNKTNPNSDAIEVLQNTVDPNTPYQPSRWNKVMRLQGAQIIENADNPDN SITKRVSTFDSSSPAENYIPLGLNNYNAEQSRERIRRPNRGNRYSKTRKP RGSLPEFDGGHAASDRSSGNYNTDPINYPFSTNNKYSNHLRVKSSKKNNS NQLGLENQGNISTPSPTHESLKVNGVNVNVYSSNHPTETVAERNQSLTSE VSIADRNETDQDLNKASSAPILSVDQNDQSENASLYKDAILDESVNADQD ISSKQLSTSDSLVINQNQSSKSVNSLQNTNLNTCGDDTVLISISSDESSD SAMSFIVDSDDTTSSSRSRRSSSVEIIILSKSDSE--xxx------ELIV LECSDIEKVEYSDVEILTPPVKTPPPLVTLESDEETQLQQDNQVIxSPKS TNTSKDxIKNKKQNQQNSSNSSVNISTSSVGGHIPLNGDNNANADVQILP ETSDESQDDFLx-SSDSNSNDRLVIDMDLNPSGQPEKVVSNVNNVAVTVK ERQTERLRKKIRKKKEKRSNALTNVEEERLFIEANEHFNHTVLQDQMSND IALWRVQPSDYATSTKSRFSKLRCHNCKELGHVVSRCTAPTKKTLCIMCG RQGHTYTRCRDIICLKAG-------------------------------- ---xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxHxxxxxxxxxxxxx xxx-------------------------------------------CGEP WTSWSTVGCDQCRTIKVQCHFCRSMDHLKNACPEVWRRYHSTVEDYIEQF DPPPAHYKPNSELSCPN------------CTKKGHKFEDCKMSIPIKKHR PDSFNGHGIYDRHTEQETDIYYSRGLTHHKRYSLPEKVNSFVDLSRHLPA -------PSTSREPPGASVDPSEVLQMVLNKGMRQPKSRTRNNRKKRARQ TMQFEETRINKQLKIMRKKDLAKKRLAKKNLKMKQIFARNINNTSGPHW >Tps -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ------------------------MDHLKNACPEVWRRYHSTVEDYIEQF DPPPALYKPNSELSCPN------------CTRKGHKFEDCKMSILFKKHR PDCFNGLGIYDRHTGQETDIYYSRGVTHRKRYSLPEKVNSSVDLSRRPPV -------PSTSRDPPGTSVDPSEVLQMVLNKGMRQPKSRTRNNRKKRARQ TMQFEETRINKQLKIMRKKDLAKKRLAKKNLKMKQIFARNLNNTTGPHW >Tdi --------------------M----------------------------- -------------------------------------------------- -------------------------------------------------- --------------------------------xxxxxxxxSxxxxxxxxx xxxxxxxxxx---------------------------------------- -------------------------------------------------- -----------LPPSILEKDDGFSTDSGSKSSSGTEDYYEEQLYALAHFS DPNKTNPNSDVIEVLQHTVDPNTPYQPSRWNKVMRLQGAQIIENADNPDN SITKRVSTFDSSSPAENYIPLGPDNYNAEQSRERIRRPNRGNRYSKTRKQ RGSLPELD---AASDRSSGNYNTDPINYPFSTSNKYSNNLRAKSSKKNNS NQLRLENQGNISPPSPTHESLKVNGVNVNIYSSNHPTETVAEPNQSLTSK VSIANQNETDQDLNKAPSAPILSVDQNDQSENASLYKDVILDESVNADQD ISSKQLSTSDSLVINQNQSSKGENSLQNTNLNTCGDNTVLISISSDESSD SAMSFVVDTDDSTSSSRSRRSSSVEIIILSNSDSE--xxx------ELIV LGCSDIEKVDYSDVEILTPPVKTPPPLVTLESDEETQSQQDNQII-SPES ANTSKDxIKNKKQNQQNSSNSSVNISTSSVGGHKPLNGDNDANADVQILP ESSDESQDDFLxVSSDSNSNDRLVIDMDLNTSGAPEKVVSNVNNVEVTVK ERQTEHMRKKIRKKKEKRSNALTNVEEERLFIEANEHFNHTVLQDQMSND IALWRVQPSDYATTTKSRFSKLRCHNCKELGHVVSRCTTPTKKILCIMCG RQGHTYTRCRDIICLKx--------------------------------- -------------------------------------------------- -------------------------------------------------- ------VGCDHCRTIKVQCHFCRSMDHLKNACPEVWRRYHSTVEDYIEQF DPPPALYKPNSELSCPN------------CTRKGHKFEDCKMSIPFKKHR PDSFNGIGIYDRHTGQETDIYYSRGVTHRKRYSLPEKVNSSVDLSRRPPV -------PSTSRDPPGTSVDPSEVLQMVLNKGMRRPKSRTRNNRKKRARQ TMQFEETRINKQLKIMRKKDLAKKRLAKKNLKMKQIFARNLNNTTGPHW >Tce --------------------x----------------------------- -------------------------------------------------- -------------------------------------------------- --------------------------------xx---------------- ---------x---------------------------------------- -------------------------------------------------- -----------ELPSILEKDDGFSSDKESKSSSGTEDHYEEQ---LAHFS DPNKTNPNSDVIEELQHTVDPNTTYQPSRWNKVMRLQGAQIIENVDNPDN SITKRVSTFDTSSPAENYIPLGLNNHNAEQNRERIRRPNRGNRYSKTRKQ RRSLPELDGGDAASDRSSGNYNTDPINYPFSTNNKYYNNRRVKSSKKNCS NQLGLENQGNISPPSPTHKSLKVNGVNDNIYSSNYPTETAVEHNQSLTSG VSIANQDKTNQDLNKTPLTSIPSVNQNNQSENASSYKDAILDETVNADQD ISSKQLPISNSLVIDQNQSNKSVNSIQNTNLNTCGDNTALISISSDESSD SAMSFIVDTDDSTSSSRSKRSSSVEIIILSKSDSESxxxx------ELIV LDCSDIEKEEYSDVEIITPPVKTPPPLVTLESDEETQIQQDNQVI-LPKS TDTSRDxIKNKKQNQQNSSNSSVNISTSSVDGNKPLNGDNDANTDVLILP ETSNESQDDFLxxSSDSNSNDRLVIDMDLNTSGEAEKVVSNVNNVEVTVK ERQTERMRKKIRKKKEKQSNALTNVEDEKLFIESNEHFNHTVLQDQMSND IALWRVQPSDYATSTKSRLSKLRCHNCKELGHIVSRCTAPTKKILCIMCG QEGHTYTRCRDIICLKA--------------------------------- -------------------------------------------------- --xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxRCGEP WTSWSTVGCDHCRTIKVQCYFCRSMDHFKNACPEVWRRYHSTIEDYIEQF DPPPTHYKPNSELSCPN------------CTRKGHMFEDCKMSSPFKKHR PDSFNGLGIYDRQTEQGTDIYYSRSVTHHKRYSLPKKMNSFVDLSRNLPI -------PSTSRDPPGTSVDPSEVLQIVLKKGMRQPKTRTRNNRKKRARQ TMQFEEMKINKQLKIMRKKDLAKKRLAKRNLKMKQMFARNINNTTDIHW >Tms --------------------xx---------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------xxxxxxxxx---------------- ---------x---------------------------------------- -------------------------------------------------- -----------xxxx------------------------xxxxxxx--xx xxxxxxx---------------------------------------xxxx xxxxxxxxxxxxxxxxxxxxxxxxxxx----------------------- ----xxxxxxxx-------------------------------------x xxxx-----xxxxxxx---------------------------------- -------------------------------------------------- -------------------------------------------------- ------------------xxxxxxxxxxxx-------------------- -----------------------------------xxxxxxxxxx----- -------------xxxxxxxxxxxxxxxxxxxxx---------------- -------------------------------------------------- ---------------------------------------KTVLLSALTNS TEL-------HAYHELSSYALLSPMHETRLGGVISx-------------- xxxxxxxxxx--------------------------------xxx----- -------------------------------------------------- -------------------------------------------------- --------------------------------------------DRGGEL DPSPPRLNLNKQVQGGGxxxxxxxxxxxxxxxxxxx-------------- xxSFGG---------------xxxxxxxxxxxxxxxxxxxxxxxxxxxxx xxxxxxxDVTSRLGPEYNYGKPHL------------------xxxxxxxx xxxxxETTLNHLLEL----------------------------------