>Tge Mxxxxxxxxxx--------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------xNLTQLDVSENSIETLDLTALGKLESVQCSK NKLVELSLNGKSLVSLIAGNNKLKKLTIHPSPVHLKHLDVSY-------- -------------------------------------------------- -------------------------NELETLPEWTAGCTRLGALFATHNK LRTLPAHLFCSELSCLQTLQLSYNQLGSLPAVLRHIPLQELFLQSNNLTT LPHNFFTAST---------------------------------------- ---------------------------------SCIAVWKDLEELLLSGN KLQHLPDNIIHLRHLRVLRVHSNRLQSSPCFAKMASLKIENISKRSAKYQ IVVYLCVQVLDLAHNRLDRINLATLVPQQLQFLDLSCNSRLYVDPRQFQV YRAHRPMSLVDVSGQNRTCLPSTPYHEEGGELEPPWKVGFSETAGLREKL YITQIRLPAFCNTEGLFGMFDGGNNNEVPDVLVRAVPRILLEERTVKETA SEYMKYTMLSAH------------------------RELKEKxxxxxxxG TLCHICRTKPTSAQSNYLPGSQRYVLRVASVGEARAVICRRNGPVTLS-- -------------------------RVIGNTASQNNLNRSQIGCSSRFPL VIPDPQITEVTLEDHDEFLIVANKRFWEVVDVDEAVEEVREVGNAILAAK KLQDIAQSYGSEENLSVMVVRFRDLGSEVEQLMRELRHTI--RRNRHQQD STPTAESSMTCGGCCCREHRVVSPGKNGFYDNRMMIPNGHGHLSNGGSLL NCNLTN-------------------------------------------- --SNFTNGTLTNGHLQNCGSKHHVVACHCASVPETERSSPSGQSDPASSD CFTTKDVAYKTKDINGRYLQQREFFSKNKAAVMVSGQSVLMHENGIKKMS SVVPTLERRSYRDSKRSGSGVVRAIRAKCSTSEEEETCSDKSGTQLSEEQ FKCWEYMLEQNTQLLFDKELDTLSRGFTRRPM--xLQHRGKALSRSNPHL SEPSPVPFLSRHFGSARSFNPVVRNTPRFSSGRHFLNGGPNAAYFGSLQR LMPYNLEYDFSVIQEKVNQDSMEQDGRMKQYWDVATTEL----------- -------------------------------------------------- -------------------------------------------------- ---------- >Tms M------------------------------------------------- -------------xxDxxxxxxxVRFTLDEDSSAxxxxRGVAARFHARDT LTAPSVPGWRAPCPWYDDVVSRHKAILPRPPRGDKSPGQISLRLRLDDTE VFRRFKIDGSPFxxxxxxxxxGLGRMERSDLKSRPGHRDLVFIHPRKCxx xxSxxxxxAVDSAxxxxxxxNLTQLDVSENSIETLDLTALGKLESVQCSK NKLVELSLNGKSLVSLIAGNNKLKKLIVHPSPVHLKHLDVSY-------- -------------------------------------------------- -------------------------NELETLPEWTAGCTRLGALFATHNK LRTLPAHLFCSELSCLQTLQLSYNQLGSLPAVLRHIPLQELFLQSNNLTT LPHNFFTASTRYYPGELRMRVLNLSNNRLCELPAECDGLRGHLLEKIYLT GNCLSDNAMDVLGRLTNLHTLHAAYNCITTLPESCIAVWKDLEELLLSGN KLQHLPDNIIHLRHLRVLRVHSNRLQSSPCFAKMASLK------------ --------VLDLAHNRLDRINLATLVPQQLQFLDLSCNSRLYVDPRQFQV YRAHRPMSLVDVSGQNRTCLPSTPYHEEGGELEPPWKVGFSETAGLREKL YITQIRLPAFCNTEGLFGMFDGGNNNEVPDVLMRAVPRILLEERTVKETA SEYMKYTMLSAH------------------------RELKEKxxxxxxxG TLCHICRTKPTSAQNNYLPGSQRYVLRVASVGEARAVICRRNGPVTLS-- -------------------------RVTSSTASQNNLNRSQIGCSSRFPL VIPDPQITEVTLEDHDEFLIVANKRFWEVVDVDEAVEEVREVGNAILAAK KLQDIAQSYGSEENLSVMVVRFRDLGSEVEQLMRELRHTI--RRNRHQQD STPTAESSMTCGGCCCREHRVVSPGKNGFYDNRVMIPNGHGHLSNGGSLL NCNLTN-------------------------------------------- --GNFTNGTLTNGHLQNCGSKHHVVACHCASVPETERSSPSGQSDPASSD CFTTRDVAYKTKDINGRYLQQREFFSKNKAAVMVSGQSVLMHENGIKKMS SVVPTLERRSYRDSKRSGSGVVRAIRAKCSTSEEEETCSDKSGTQLSEEQ FKCWEYMLEQNTQLLFDKELDTLSRGFTRRPLSASLQHRGKALSRSNPHL SEPSPVPFLSRHFGSARSFNPVVRNTPRFSSGRHFLNGGPNAAYFGSLQR LMPYNLEYDFSVIQEKANQDSMEQDGRMKQYWDVATTEL----------- -------------------------------------------------- -------------------------------------------------- ---------- >Tce M------------------------------------------------- -------------xxxxxxxxxxxxxxxxxxxxxxxxxxxxxAxxHARDT xxxxxxxxxxxxxxxxxxxxSRHKAIxxxxxxxxxxxGQISLRLRLDDTE VFxxxxxxxxxx-------------------------------------- -------------------xxxxQxxxxxxxxxxxxxxxxxxxxxxxxxx xxxxxxxxxxxxxxxxxxxxNKLKKLIVHPSPVHLxxxxxxx-------- -------------------------------------------------- -------------------------NELETLPEWTAGCTRLGALFATHNK LRTLPAHLFCSELSCLQTLQLSYNQLGSLPAVLRHIPLQELFLQSNNLTT LPHNFFTASTxxxxxxxRMRVLNLSNNRLCELPAECEGLRGHLLEKIYLT GNCLSDNAMDVLGRLTNLHTLHAAYNCITTLPESCIAVWKDLEELLLSGN KLQHLPDNIIHLRHLRVLRVHSNRLQSSPCFAKMASLK------------ --------VLDLAHNRLDRINLATLVPQQLQFLDLSCNSRLYVDPRQFQV YRAHRPMSLVDVSGQNRTCLPSTPYHEEGGELEPPWKVGFSETAGLREKL YITQIRLPAFCNTEGLFGMFDGGNNNEVPDVLMRAVPRILLEERTVKETA SEYMKYTMLSAH------------------------RELKxxxxxxxxxG TLCHICRTKPTSAQNNYLPGSQRYVLRVASVGEARAVICRRNGPVTLS-- -------------------------RVTSSTASQNNLNRSQIGCSSRFPL VIPDPQITEVTLEDHDEFLIVANKRFWEVVDVDEAVEEVREVGNAILAAK KLQDIAQSYGSEENLSVMVVRFRDLGSEVEQLMRELRHTI--RRNRHQQD STPTAESSMTCGGCCCREHRVVSPGKNGFYDNRVMIPNGHGHLSNGGSLL NCNLTN-------------------------------------------- --GNFTNGTLTNGHLQNCGSKHHVVACHCASVPETERSSPSGQSDPASSD CFTTRDVAYKTKDINGRYLQQREFFSKNKAAVMVSGQSVLMHENGIKKMS SVVPTLERRSYRDSKRSGSGVVRAIRAKCSTSEEEETCSDKSGTQLSEEQ FKCWEYMLEQNTQLLFDKELDTLSRGFTRRPLSASLQHRGKALSRSNPHL SEPSPVPFLSRHFGSARSFNPVVRNTPRFSSGRHFLNGGPNAAYFGSLQR LMPYNLEYDFSVIQEKANQDSMEQDGRMKQYWDVATTEL----------- -------------------------------------------------- -------------------------------------------------- ---------- >Tsi xx--------xxxxxxxxxxxxx--------------------------- ----xxxxxxxxxx------------------------------------ -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------NELETLPEWTAGCTRLGALFATHNK LRTLPAHLFCSELSCLQTLQLSYNQLGSLPAVLRHIPLQELFLQSNNLTT LPHNFLTAST-------RMRVLNLSNNRLCELPAECEGLRGHLLEKIYLT GNCLSDNAMDVLGRLTNLHTLHAAYNCITTLPESCIAVWKDLEELLLSGN KLQHLPDNIIHLRHLRVLRVHSNRLQSSPCFAKMASLKIENISKRFAKYQ IVVYLCVQVLDLAHNRLDRINLATLVPQQLQFLDLSCNSRLYVDPRQFQV YRAHRPMSLVDVSGQNRTCLPSTPYHEEGGELEPPWKVGFSETAGLREKL YITQIRLPAFCNTEGLFGMFDGGNNNEVPDVLMRAVPRILLEERTVKETA NEYMKYTMLSAH------------------------RELKEKxxxxxxxG TLCHICRAKPTSAQNNYLPGSQRYVLRVASVGEARAVICRRNGPVTLS-- -------------------------RVTSSTASQNNLNRSQIGCSSRFPL VIPDPQITEVTLEDHDEFLIVANKRFWEVVDVDEAVEEVREVGNAILAAK KLQDIAQSYGSEENLSVMVVRFRDLGSEVEQLMRELRHTI--RRNRHQQD STPTAESSMTCGGCCCREHRVVSPGKNGFYDNRVMIPNGHGHLSNGGSLL NCNLTN-------------------------------------------- --GNFTNGTLTNGHLQNCGSKHHVIACHCASVPETERSSPSGQSDPASSD CFTTRDVAYKTKDINGRYLQQREFFSKNKAAVMVSGQSVLMHENGIKKMS SVVPTLERRSYRDSKRSGSGVVRAIRAKCSTSEEEETCSDKSGTQLSEEQ FKCWEYMLEQNTQLLFDKELDTLSRGFTRRPMSASLQHRGKALSRSNPHL SEPSPVPFLSRHFGSARSFNPVVRNTPRFSSGRHFLNGGPNAAYFGSLQR LMPYNLEYDFSVIQEKANQDSMEQDGRMKQYWDVATTEL----------- -------------------------------------------------- -------------------------------------------------- ---------- >Tcm -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ------MSLVDVSGQNRTCLPSTPYHEEGGELEPPWKVGFSETAGLREKL YITQIRLPAFCNTEGLFGMFDGGNNNEVPDVLMRAVPRILLEERTVKETA NEYMKYTMLSAH------------------------RELKEKxxxxxxxG TLCHICRAKPTSAQNNYLPGSQRYVLRVASVGEARAVICRRNGPVTLS-- -------------------------RVTSSTASQNNLNRSQIGCSSRFPL VIPDPQITEVTLEDHDEFLIVANKRFWEVVDVDEAVEEVREVGNAILAAK KLQDIAQSYGSEENLSVMVVRFRDLGSEVEQLMRELRHTI--RRNRHQQD STPTAESSMTCGGCCCREHRVVSPGKNGFYDNRVMIPNGHGHLSNGGSLL NCNLTN-------------------------------------------- --GNFTNGTLTNGHLQNCGSKHHVIACHCASVPETERSSPSGQSDPASSD CFTTRDVAYKTKDINGRYLQQREFFSKNKAAVMVSGQSVLMHENGIKKMS SVVPTLERRSYRDSKRSGSGVVRAIRAKCSTSEEEETCSDKSGTQLSEEQ FKCWEYMLEQNTQLLFDKELDTLSRGFTRRPMSASLQHRGKALSRSNPHL SEPSPVPFLSRHFGSARSFNPVVRNTPRFSSGRHFLNGGPNAAYFGSLQR LMPYNLEYDFSVIQEKANQDSMEQDGRMKQYWDVATTEL----------- -------------------------------------------------- -------------------------------------------------- ---------- >Tte -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------NPVVRNTPRFSSGRHFLNGGPNAAYFGSLQR LMPYNLEYDFSVIQEKANQDSMEQDGRMKQYWDVATTEL----------- -------------------------------------------------- -------------------------------------------------- ---------- >Tbi x------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------RVLNLSNNRLCELPAECEGLRGHLLEKIYLT GNCLSDNAMDVLGRLTNLHTLHAAYNCITTLPESCIAVWKDLEELLLSGN KLQHLPDNIIHLRHLRVLRVHSNRLQSSPCFAKMASLK------------ --------VLDLAHNRLDRINLATLVPQQLQFLDLSCNSRLYVDPRQFQV YRAHRPMSLVDVSGQNRTCLPSTPYHEEGGELEPPWKVGFSETAGLREKL YITQIRLPAFCNTEGLFGMFDGGNNNEVPDVLVRAVPRILLEERTVKETA SEYMKYTMLSAHxxxxxxxxxxxxxxxxxxxxxxxxx------------- --------------NNYLPGSQRYVLRVASVGEARAVICRRNGPVTLS-- -------------------------RVTGNTASQNNLNRSQIGCSSRFPL VIPDPQITEVTLEDHDEFLIVANKRFWEVVDVDEAVEEVREVGNAILAAK KLQDIAQSYGSEENLSVMVVRFRDLGSEVEQLMRELRHTIxPRRNRHQQD STPTAESSMTCGGCCCREHRVVSPGKNGFYDNRMMIPNGHGHLSNGSSLL NCNITN-------------------------------------------- --SNFTNGTLTNGHLQNCGSKHHVVACHCASVPETERSSPSGQSDPASSD CFTTKDVAYKTKDINGRYLQQREFFSKNKAAVMVSGQSVLMHENGIKKMS SVVPTLERRSYRDSKRSGSGVVRAIRAKCSTSEEEETCSDKSGTQLSEEQ FKCWEYMLEQNTQLLFDKELDTLSRGFTRRPM--SLQHRGKALSRSNPHL SEPSPVPFLSRHFGSARSFNPVVRNTPRFSSGRHFLNGGPNAAYFGSLQR LMPYNLEYDFSVIQEKANQDSMEQDGRMKQYWDVATTEL----------- -------------------------------------------------- -------------------------------------------------- ---------- >Tps xx--------xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx xxxxx--------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------L YITQIRLPAFCNTEGLFGMFDGGNNNEVPDVLMRAVPRILLEERTVKETA NEYMKYTMLSAH------------------------RELKEKxxxxxxxG TLCHICRTKPTSAQNNYLPGSQRYVLRVASVGEARAVICRRNGPVTLS-- -------------------------RVTSSTASQNNLNRSQIGCSSRFPL VIPDPQITEVTLEDHDEFLIVANKRFWEVVDVDEAVEEVREVGNAILAAK KLQDIAQSYGSEENLSVMVVRFRDLGSEVEQLMRELRHTI--RRNRHQQD STPTAESSMTCGGCCCREHRVVSPGKNGFYDNRVMIPNGHGHLSNGGSLL NCNLTN-------------------------------------------- --GNFTNGTLTNGHLQNCGSKHHVVACHCASVPETERSSPSGQSDPASSD CFTTRDVAYKTKDINGRYLQQREFFSKNKAAVMVSGQSVLMHENGIKKMS SVVPTLERRSYRDSKRSGSGVVRAIRAKCSTSEEEETCSDKSGTQLSEEQ FKCWEYMLEQNTQLLFDKELDTLSRGFTRRPMSASLQHRGKALSRSNPHL SEPSPVPFLSRHFGSARSFNPVVRNTPRFSSGRHFLNGGPNAAYFGSLQR LMPYNLEYDFSVIQEKANQDSMEQDGRMKQYWDVATTEL----------- -------------------------------------------------- -------------------------------------------------- ---------- >Tdi M------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -----------------------------------------xxPxxxxxx xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx -----------xxxxxxxxxxxxxxNELETLPEWTAGCTRLGALFATHNK LRTLPAHLFCSELSCLQTLQLSYNQLGSLPAVLRHIPLQELFLQSNNLTT LPHNFLTAST-------RMRVLNLSNNRLCELPAECEGLRGHLLEKIYLT GNCLSDNAMDVLGRLTNLHTLHAAYNCITTLPESCIAVWKDLEELLLSGN KLQHLPDNIIHLRHLRVLRVHSNRLQSSPCFAKMASLK------------ --------VLDLAHNRLDRINLATLVPQQLQFLDLSCNSRLYVDPRQFQV YRAHRPMSLVDVSGQNRTCLPSTPYHEEGGELEPPWKVGFSETAGLREKL YITQIRLPAFCNTEGLFGMFDGGNNNEVPDVLMRAVPRILLEERTVKETA NEYMKYTMLSAH------------------------RELKxxxxxxxxxG TLCHICRAKPTSAQNNYLPGSQRYVLRVASVGEARAVICRRNGPVTLSxx xxxHCLSECKRPFQIxxxxxxxxxxxx--------NLNRSQIGCSSRFPL VIPDPQITEVTLEDHDEFLIVANKRFWEVVDVDEAVEEVREVGNAILAAK KLQDIAQSYGSEENLSVMVVRFRDLGSEVEQLMRELRHTI--RRNRHQQD STPTAESSMTCGGCCCREHRVVSPGKNGFYDNRVMIPNGHGHLSNGGSLL NCNLTNxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx xxx----------------------------------------------- ----------------RYLQQREFFSKNKAAVMVGGQSVLMHENGIKKMS SVVPTLERRSYRDSKRSGSGVVRAIRAKCSTSEEEETCSDKSGTQLSEEQ FKCWEYMLEQNTQLLFDKELDTLSRGFTRRPMSASLQHRGKALSRSNPHL SEPSPVPFLSRHFGSARSFNPVVRNTPRFSSGRHFLNGGPNAAYFGSLQR LMPYNLEYDFSVIQEKANQDSMEQDGRMKQYWDVATTEFEIPCHLMALLH TMPTQQHYPDNHRLVGGPLDKYTDISAQSRWPLVCSCHLALFGFVFREYD IVTVIEFVESRVCLWDFLFGFGVVFFGDEANTIKETSYSKWEPCCLLATI HKTVMPLKHR >Tpa xx------------------------------------------------ -------------------------------------------------- -------------x------------------------------------ -------------------------------------------------- ----xxxxxxxx-------------------------------------- -------------------------------------------xxxxxxx xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx xxxxxxxxxxxx------------xxxxxxxxxxxxxxxxxxxxxxxxxx xxxxxxxLFxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx xxxxxxxxxx-------xx------------------------------- ------------------------xxx----------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- --------xx