>Tge -------------------------------------------------- ------------------------------------xxxxxxxxxxxxxx xxxxxxVEDVTxxxxxxxxxxxxxxxxxxxxYRSQRVKNGQKGGGLTLFE KKLDLVNQRQQSEIFQGDRIGGGLDRVILQVFRRPDQYSNPxxxxxxxxx xxECDTLDHSxTEAGNNHISREGMFQIPKTCKKELSRQTSDVSxxxxxxx xxxxxxxxxxxLRKPKERSLACLMxLTNPVGALLLFVCVIHFPIMDVKSK xxxSVHQAFNSDSxxFLLSDNDSFIxxGxLKNAKxxxxxxxVKHPFTEQV RTCFWGKxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxGYPPPKDGPYSSC VSRDESGxGGMVExSTTGFIHMKLEEEAPIFSKQKVNFSPTERMTHLAVS SDLLVLTMANSMLLRIDLKQPDKREEIDLSKFTTHLKILELFLDPLGQHL IISLTPKHPDNQPEILYLPRKSNKPKQPGKFKGYEVTAVGWNYRNDYETT TGPILLGTSKGLIFETEILPEGDRIFQSGLEQYWKQGMExxxVRIxxxxx xxxxxxxFxIExPSRxxxxxxxxxxxxxxIETxxxxSK------------ -------------------------------VFDIGKGANTPITGIEFHR VPGSEKYFVLVTTPDRVYQFIGYVSNSDEKPLLQQVFNNYLTVAEAFQEI PSSLKYSKLQFLYHSPKGLPRIFAWLTEPGIFYAQLDPTGTASVLTNNQL LQYPSSSLAPLSFVLTEFHALLLYSDHVRGISMLNHELVFEDYYNE---- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -----------------------------------------------SFG KLVSITKDPIKGTIWAFAERAVFRYKVTHEERNVWQVYVEKGEFELAKKY CRDNPAHIDQVLVKQADM----------------YEQSALHYAETQSSFE EIALKFLQVWEIEALKTFLIKKLEGFKPQDKTQVTMIVVWVIELFLNQLG VLRDKGEVNTSQYSILQKQLDSFLTHKEVKECVMTNRSTIYDLMASHGDK HNLIRLTIMNKDFERVIRHHINKNNYLEALDVLKGQNKKELFYQFTPALV QAIPKQTIQALIAQGRTLSPNKLLPALVTCDDDQAGEVIRYLEFCIHSLG CQQQAIHNYLLSLYAKLKPDKLMQYLTMQGQDSTMVCYDIHYALRLCRER GLSEACVQLSALLGLWEVAVDLALTVNVDLAKQTANMPQNDTELRKKLWL KIA---------------------------QHVxxxKxxxxxxxxFLxxx xxxxxEDILPFFSDFVTIDHFKDAICxxxxxxxxxxxDLxEEMEEAxxxx xxxxxxxxxxxNRCxxxxxHDVCSLCDLRLLMxxFYLFPCGHRFHSDCLV SDLSPMLPPGKRNKMLELQ------------------------------- ----------------------x--------------------------- -------------------------------------------------- -------------QLNLYSSxxxTxxxxxxxxxxxxxxxxxxxxxxxxxx xxxxxxxxxxxxxxxxxxxxxxxxxxxxx >Tte x------------------------------------------------- ------------------------------xxxxxx-------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- --------------STTGFIHMKLEEEAPIFSKQKVNFSPTERMTHLAVS SDLLVLTMANSMLLRIDLKQPDKREEIDLSKFTTHLKILELFLDPLGQHL IISLTPKHPDNPPEILYLPRKSNKPKQPGKFKGYEVTAVGWNYRNDYETT TGPILLGTSKGLIFETEILPEGDRIFQSGLEQYWKQ-------------- -------------------------------------------------- -------------------------------VFDIGKGANTPITGIEFHR VPGSEKYFVLVTTPDRVYQFIGYVSNSDEKPLLQQVFNNYLTVAEAFQEI PSSLKYSKLQFLYHSPKGLPRIFAWLTEPGIFYAQLDPTGTASVLTNNQL LQYPSSSMAPLSFVLTEFHALLLYSDHVRGISMLNHELVFEDYYNE---- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -----------------------------------------------SFG KLVSITKDPIKGTIWAFAERAVFRYKVTHEERNVWQVYVEKGEFELAKKY CRDNPAHIDQVLVKQADM----------------YEQSALHYAETQSSFE EIALKFLQVWEIEALKTFLIKKLEGFKPQDKTQVTMIVVWVIELFLNQLG VLRDKGEVNTSQYSILQKQLDSFLTHKEVKECVMTNRSTIYDLMASHGDK HNLIRLTIMNKDFERVIRHHINKNNYLEALDVLKGQNKKELFYQFTPALV QAIPKQTIQALIAQGRTLSPNKLLPALVTCDDDQAGEVIRYLEFCIHSLG CQQQAIHNYLLSLYAKLKPDKLMQYLTMQGQDSTMVCYDIHYALRLCRER GLSEACVQLSALLGLWEVAVDLALTVNVDLAKQTANMPQNDTELRKKLWL KIA---------------------------QHVxxxKxxxxxxxxFLxxx xxxxxxxILPFFSDFVTIDHFKDAIxxxxxxxxxxxxDLxEEMEEAxxxx xxxxxxxxxxxNRCxxxxxHDVCSLCDLRLLMxxFYLFPCGHRFHSDCLV SDLSPMLPPGKRNKMLELQxxxxxxxxxxxxxxxxxxxxxxxx------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ----------------------------- >Tsi xxIHPTEIRTSISSSSAVELNxxSALANxxxxxxxxxxxxxxxxxxxATA xxPEMGYPPPKVRSYSPSGFINVSGEGGxxVPRLFQ-------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- --------------STTGFIHIKLEEEAPIFSKQKVNFSPTERITHLAVS SDLLVLTMANSMLLRIDLKQPDNREEIDLSKFTTHLKILELFLDPLGQHL IISLTPKNPDNPPEILYLSRKSNKPKQPGKFKGYEVTAVGWNYRNDYETT TGPILLGTSKGLIFETEILPEGDRIFQSGLEQYWKQ-------------- -------------------------------------------------- -------------------------------VFDIGKGDNTPITGIEFHR VPGSEKYFVLVTTPDRVYQFIGYVSNSDEKPLLQQVFNNYLTVAEAFQEI PSSLKYSKLQFLYHSPSGLPRIFAWLTEPGIFYAQLDPTGTASVLTNNQL LQYPSPSLAPLSFVLTEFHALLLYPDHVRGISMLNHELVFEDYYNE---- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -----------------------------------------------SFG KLVSITKDPIKGTIWAFAERAVFRYKVTHEERNVWQ------------KY CRDNPAHIDQVLVKQAEM----------------YEQSALHYAETQSSFE EIALKFLQVWEIEALKTFLIKKLEGFKSQDKTQVTMIVVWVIELFLNQLG VLRDKGEVNSPQYSILQKQLDSFLTHKEVKECVMNNKSTIYDLMASHGDK HNLIRLTIMNKDFERVIRHHINKNNYLEALDVLKGQNKKELFYQFTPALV QAIPKQTIQALIAQGRTLSPNKLLPALVTCDDDQAGEVIRYLEFCIHSLG CQQQAIHNYLLSLYAKLKPDKLMQYLAMQGQDSTMVCYDIHYALRLCREL GLSEACVQLSALLGLWEVAVDLALTVNVDLAKQTANMPQNDTELRKKLWL KIA---------------------------QHVxxxKxxxxxxxxFLxxx xxxxxEDILPFFSDFVTIDHFKDAICxxxxxxxxxxxDLxEDMEEAxxxx xxxxxxxxxxxNRCxxxxxRDVCSLCDLRLLMxxFYLFPCGHRFHSDCLV ADLSPVLPPGKRNKMLELQ------------------------------- -------------------------------------------------- -------------------------------------------------- ----------------------xTxxxxxxxxxxxxxxxxxxxxxxxxxx xxxxxxxxxxxxxxxxxxxxxxxxxxxxx >Tps -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -----------------MYFNNKQ----------YEQSALHYAETQSSFE EIALKFLQVWEIEALKTFLIKKLEGFKSQDKTQVTMIVVWVMELFLNQLG VLRDKGEVNSPQYSILQKQLDSFLTHKEVKECVMNNKSTIYDLMASHGDK HNLIRLTIMNKDFERVIRHHINKNNYLEALDVLKGQNKKELFYQFTPALV QAIPKQTIQALIAQGRTLSPNKLLPALVTCDDDQAGEVIRYLEFCIHSLG CQQQAIHNYLLSLYAKLKPDKLMQYLAMQGQDSTMVCYDIHYALRLCREL GLSEACVQLSALLGLWEVAVDLALTVNVDLAKQTANMPQNDTELRKKLWL KI------------------------------------------------ -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ----------------------------- >Tdi xx---------------------------------xxxxxxxxxxxxATA xxPEx--------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- --------------STTGFIHIKLEEEAPIFSKQKVNFSPTERITHLAVS SDLLVLTMANSMLLRIDLKQPDNREEIDLSKFTTHLKILELFLDPLGQHL IISLTPKNPDNPPEILYLSRKSNKPKQPGKFKGYEVTAVGWNYRNDYETT TGPILLGTSKGLIFETEILPEGDRIFQSGLEQYWKQ-------------- -------------------------------------EHxxxxTDNxxxx xxxxxxxGLHVVxGSLxxxxxxxFRVxxxAVVFDIGKGDNTPITGIEFHR VPGSEKYFVLVTTPDRVYQFIGYVSNSDEKPLLQQVFNNYLTVAEAFQEI PSSLKYSKLQFLYHSPKGLPRIFAWLTEPGIFYAQLDPTGTASVLTNNQL LQYPSPSLAPLSFVLTEFHALLLYPDHVRGISMLNHELVFEDYYNE---- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -----------------------------------------------SFG KLVSITKDPIKGTIWAFAERAVFRYKVTHEERNVWQVYVEKGEFELAKKY CRDNPAHIDQVLVKQAEM----------------YEQSALHYAETQSSFE EIALKFLQVWEIEALKTFLIKKLEGFKSQDKTQVTMIVVWVIELFLNQLG VLRDKGEVNSPQYSILQKQLDSFLTHKEVKECVMNNKSTIYDLMASHGDK HNLIRLTIMNKDFERVIRHHINKNNYLEALDVLKGQNKKELFYQFTPALV QAIPKQTIQALIAQGRTLSPNKLLPALVTCDDDQAGEVIRYLEFCIHSLG CQQQAIHNYLLSLYAKLKPDKLMQYLAMQGQDSTMVCYDIHYALRLCREL GLSEACVQLSALLGLWEVAVDLALTVNVDLAKQTANMPQNDTELRKKLWL KIA---------------------------QHVxxxKxxxxxxxxFLxxx xxxxxEDILPFFSDFVTIDHFKDAICxxxxxxxxxxxDLxEDMEEAxxxx xxxxxxxxxxxNRCxxxxxRDVCSLCDLRLLMxxFYLFPCGHRFHSDCLV ADLSPVLPPGKRNKMLELQ------------------------------- ----------------------xxxxxxxxxxxxxxxxxxxxxxxxxxxx xxNSITVTILSFTSNSLKQNKKYSLSDRIPFKIPENPNFILTYLPQTPRP LIAIHYVYCLFKxxxNLYSSxxxTxxxxxxxxxxxxxxxxxxxxxxxxxx xxxxxxxxxxxxxxxxxxxxxxxxxxxxx >Tbi xx---------------------SLL-------DQYEQASQRYKGTVGTS LRPEM--------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- --------------STTGFIHMKLEEEAPIFSKQKVNFSPTERMTHLAVS SDLLVLTMANSMLLRIDLKQPDKREEIDLSKFTTHLKILELFLDPLGQHL IISLTPKHPDNPPEILYLPRKSNKPKQPGKFKGYEVTAVGWNYRNDYETT TGPILLGTSKGLIFETEILPEGDRIFQSGLEQYWKQ-------------- -------------------------------------------------- -------------------------------VFDIGKGANTPITGIEFHR VPGSEKYFVLVTTPDRVYQFIGYVSNSDEKPLLQQVFNNYLTVA----EI PSSLKYSKLQFLYHSPKGLPRIFAWLTEPGIFYAQLDPTGTASVLTNNQL LQYPSSSMAPLSFVLTEFHALLLYSDHVRGISMLNHELVFEDYYNERTFS TLMKKYEIIQEVDEKKITKTEITRWHGIPKSTLFMILKMREEIVNVVQKE GHNIKAKNLKGATHANLKAMEGIVVSWRAVRPVVITNYFRHSRFVPPVNE GTAVYPCDEETWQRLALDCTYQEYIAADDDITVWGTLDNADIIREQQEFS DEEGKESMEEEPEDIPTMKNVLKGVDVYSRVLKRQGASEDLWFQFYNSFG KLVSITKDPIKGTIWAFAERAVFRYKVTHEERNVWQVYVEKGEFELAKKY CRDNPAHIDQVLVKQADMYFNNKQ----------YEQSALHYAETQSSFE EIALKFLQVWEIEALKTFLIKKLEGFKPQDKTQVTMIVVWVIELFLNQLG VLRDKGEVNTSQYSILQKQLDSFLTHKEVKECVMTNRSTIYDLMASHGDK HNLIRLTIMNKDFERVIRHHINKNNYLEALDVLKGQNKKELFYQFTPALV QAIPKQTIQALIAQGRTLSPNKLLPALVTCDDDQAGEVIRYLEFCIHSLG CQQQAIHNYLLSLYAKLKPDKLMQYLTMQGQDSTMVCYDIHYALRLCRER GLSEACVQLSALLGLWEVAVDLALTVNVDLAKQTANMPQNDTELRKKLWL KIASxxxxxxxxxxxxxxxxxxxxxxxxxxx------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ----------------------------x >Tpa -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ------------------------------------VYVEKGEFELAKKY CRDNPAHIDQVLVKQADMYFNNKQLSKRRVNxxxYEQSALHYAETQSSFE EIALKFLQVWEIEALKTFLIKKLEGFKPQDKTQVTMIVVWVIELFLNQLG VLRDKGEVNTSQYSILQKQLDSFLTHKEVKECVMTNRSTIYDLMASHGDK HNLIRLTIMNKDFERVIRHHINKNNYLEALDVLKGQNKKELFYQFTPALV QAIPKQTIQALIAQGRTLSPNKLLPALVTCDDDQAGEVIRYLEFCIHSLG CQQQAIHNYLLSLYAKLKPDKLMQYLTMQG-------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ----------------------------- >Tcm -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------xxFLxxx xxxxxxxILPFFSDFVTIDHFKDAIxxxxxxxxxxxxxxxEDMEEAxxxx xxxxxxxxxxxxxxxxxxxRDVCSLCDLRLLMxxFYLFPCGHRFHSDCLV ADLSPVLPPGKRNKMLELQ----------------------xxxxxxxxx xxxxxxxxxxxxxxxxxxxxxxxx-------------------------- -------------------------------------------------- -------------------------------------------------- -----------------------------