>Tge M-----xxxAxxxxxxAQSMIxxxxxxxxTLRVWVTPSLHLGxxxxRxNR GIxRxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx------ -------------------------xxxEDxxxxxxxxxxxxFIARLFIF LCKTAQRGLVNQTLRLxxxKxxxxxxTxLxxxxxxxxxxxxVxxRNGxxx xxxxxxxx------------------------------------------ -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ----------------xxxxxxxEEPPDRYSNLDLP----------VIGS LVxxESSxxxxxxxxxxxxxxxxxxxxxxx-------------------- ----------------------xxxxxxxPHIPGKQEHHTSLTFSxxxxx xxxxxxxxxxxxxxxxxxxxxxxxxxx-------xxxxxxxxxxxxxxxx xxxxxxxxxGAGKSSLLNVMAGYKCKGTGGQILVNGRDRSKRSLDEFYRL SCYIMQDDHLREVLTARESMSIASSLKLGRST------------------ -----------------------------------------SSKEREAxV RExxxxxxxxxxxxxxxxxxxxxxxxQIEELLEMLGLSECQKTRCGQLSG GQKKRLSIALELISNPPVLFLDEPTTGLDSSSCSQCIALLKQLAQDGRTV ICTIHQPSAKVFEMFDHLYTLSEGRCVYQGSIVELMPFLGGFGLHCPPYH NPADFLLEAATGEFGTEVSTLAQAAESLKRTEERST-------------- -----------------------------ILRSQYKYYTTDFEASLAKET QKDPTQNNGAVVDEGEDVAISINKPASVWNQFLIIYLRNLVIMRRDYSNV MIRVLAHLLIGLLFGYLYKGVGNNGNTVLANYVYIYGSTLFLVYTGKMSV MLM-------------FPLEFQMLTREHFNRWFSLPPYLLSVILVEAPIQ VISSLMYLVISYVLTDQIMEPQRMGLFIMLGVTVSLTAQSAGFLVGVTTP IKIAVFLGPMVACLLSMFGFNIFFRDTPYLLRWLFHISYFRAAFQGSVFA MYGLNRTNLDCDILYCHMKLPSKILQTLDMEDVDIWGNMEMLVGMWCLIH LSTIIAIWFRLNKR------------------------------------ -------------------------------------------------- -------------------------------------------------- --- >Tpa -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ---------------------------IEELLEMLGLSECQKTRCGQLSG GQKKRLSIALELISNPPVLFLDEPTTGLDSSSCSQCIALLKQLAQDGRTV ICTIHQPSAKVFEMFDHLYTLSEGRCVYQGSIVELMPFLGGFGLHCPPYH NPADFLLEAATGEFGTEVSTLAQAAESLKRTEERST-------------- -----------------------------VLRSQYKYYTTDFEASLAKET QKDPTQNNGAVVDEGEDVAISINKPASVWNQFLIIYLRNLVIMRRDYSNV MIRVLAHLLIGLLFGYLYKGVGNNGNTVLANYVYIYGSTLFLVYTGKMSV MLMxxxx-------xx---------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- --- >Tsi xxxxxxx------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- --------------------------------------xxxxxxxxxxxx xxxxxxxxxGAGKSTLLNVLAGYKCKGTGGQVLVNGRDRGKRSLDEFSRL SCYIMQDDHLREVLTARESMSIASSLKLxxxx------------------ -----------------------------------------SSKEREA-- --------------------------QIEELLEMLGLTECQKTRCAQLSG GQKKRLSIALELISNPPVLFLDEPTTGLDSSSCSQCVALLKRLAQDGRTV ICTIHQPSAKIFEMFDHLYTLSAGRCVYQGSIVALMPFLEGFGLQCPPYH NPADFLLEAATGEFGTEVSTLAQAAESLKRTEERST-------------- -----------------------------LLRSQYKYYATDFEASLAKEK QKDPTQNNGAVVDEGEDVSISINKPASVWDQFLIIYLRNLVIMRRDYSNV TVRILAHLLIGLLFGYLYKGVGNNGNTVLANYVYIYGSTLFLVYTGKMSV MLM-------------FPLEFQMLTREHFNRWYSLPPYLLSVILIEAPIQ VISSLMYLVISYILTDQIMDPQRMGLFIMLGVTVSLTAQGAGFLVGVTTP IKIAVFLGPMVACLLSMFGFNIFFRDTPYLLRWLFHISYFRAAFQGSVFA MYGLNRTNLECDILYCHMKLPSKILQTLDMEDVDIWGNMEMLVGMWCLIH LTTIVAIWFRLNRR------------------------------------ -------------------------------------------------- -------------------------------------------------- --- >Tms x------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- --------------------------xxxxxxxxxxxxxxxxxxxxxxxx xxxxxxxxxGAGKSTLLNVMAGYKCKGTGGQILVNGRDRNKRSLDEFSRL SCYIMQDDHLREVLTARESMSIASSLKLGRSTxxxxxRxxGxxxxxxxxx xxxTEQxxxxxxxxxxxxxxxxxxxxxxERTVARREKxxxxxSKRREA-- --------------------------QIEELLEMLGLTECQKTRCAQLSG GQKKRLSIALELISNPPVLFLDEPTTGLDSSSCSQCVALLKQLAQDGRTV ICTIHQPSAKIFEMFDHLYTLSEGRCVYQGSIVELMPFLEGFGLQCPPYH NPADFLLEAATGEFGTEVSTLALAAESLKRTEERST-------------- -----------------------------ILRSQY---------xLAKEK QKDPTQNNGAVVDEGEDVAISINKPASVWDQFLIIYLRNLVIMRRDYSNV TVRVLAHLLIGLLFGYLYKGVGNNGNTVLANYVYIYGSTLFLVYTGKMSV MLM-------------FPLEFQMLTREHFNRWYSLPPYLLSVILIEAPIQ VISSLMYLVISYLLTDQIMEPQRMGLFIMLGVTVSLTAQGAGFLVGVTTP IKIAVFLGPMLACLLSMFGFNIFFRDTPYLLRWLFHISYFRAAFQGSVFA MYGLNRTNLECDILYCHMKLPSKILQTLDMEDVDIWGNMEMLVGMWCLIH LTTIVAIWFRLNRR------------------------------------ -------------------------------------------------- -------------------------------------------------- --- >Tps x------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------xxxxxxxxxxxxxxxxxxxxxxxx------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- --------------------------GLDSSSCSQCVALLKRLAQDGRTV ICTIHQPSAKIFEMFDHLYTLSAGRCVYQGSIVELMPFLEGFGLQCPPYH NPADFLLEAATGEFGTEVSTLAQAAESLKRTEERST-------------- -----------------------------KLRSQYKYYATDFEASLAKEK QKDPTQNNGAVVDEGEDVAISINKPASVWDQFLIIYLRNLVIMRRDYSNV MVRVLAHLLIGLLFGYLYKGVGNNGNTVLANYVYIYGSTLFLVYTGKMSV MLM-------------FPLEFQMLTREHFNRWYSLPPYLLSVILIEAPIQ VISSLMYLVISYILTDQIMDPQRMGLFIMLGVTVSLTAQGAGFLVGVTTP VKIAVFLGPMLACLLSMFGFNIFFRDTPYLLRWLFHISYFRAAFQGSVFA MYGLNRTNLECDILYCHMKLPSKILQTLDMEDVDIWGNMEMLVGMWCLIH LTTIVAIWFRLNRR------------------------------------ -------------------------------------------------- -------------------------------------------------- --- >Tcm M------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ------------------------------xxxGxxxxxxMVELExxxxx xxxxxxxxxxxKxHQVHPxxxxxxxxxxxxxxxxxxxxxxxxxxxxDNxx xxxxxxxxTDLSLFSITFLSIDRLIVSDxxxxxNxLxVWSxxxxxxxxEx xISExxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxLNQE MPKNWEGxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx xxxxxxxxxxxxxxxxxxWEIIFxxxxxxx-----xxxxxxxxxxxxxxx xxxxxxxxxxxxxxxx---------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ---------------------------IEELLEMLGLTECQKTRCAQLSG GQKKRLSIALELISNPPVLFLDEPTTGLDSSSCSQCVALLKRLAQDGRTV ICTIHQPSAKIFEMFDHLYTLSAGRCVYQGSIVALMPFLEGFGLQCPPYH NPADFLLEAATGEFGTEVSTLAQAAESLKRTEERST-------------- -----------------------------KLRSQYKYYATDFEASLAKEK QKDPTQNNGAVVDEGEDVAISINKPASVWDQFLIIYLRNLVIMRRDYSNV TVRILAHLLIGLLFGYLYKGVGNNGNTVLANYVYIYGSTLFLVYTGKMSV MLM-------------FPLEFQMLTREHFNRWYSLPPYLLSVILIEAPIQ VISSLMYLVISYILTDQIMDPQRMGLFIMLGVTVSLTAQGAGFLVGVTTP VKIAVFLGPMLACLLSMFGFNIFFRDTPYLLRWLFHISYFRAAFQGSVFA MYGLNRTNLECDILYCHMKLPSKILQTLDMEDVDIWGNMEMLVGMWCLIH LTTIVAIWFRLNRRGYPKALVCSQIDRAQNSGPTTSTGTNNIIPLVTTYH PGLHKLNNLLKTGFPILQSSTTTQLVFKEPPKVTYKQPANLRNLLVKPKL LDPTIQPEPKQISVHPTKIRTLIAPSSAVELNTTSALANYATEAGFITYK NIS >Tbi x------------------------------------------------- -------------------------------------------xxxxxxx xxxxxxxSxxxxxxxxxxxxxxxxxx------------------------ -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -----------------------------xxxxxxxxxxxxxxxxxxxxx xxxxxxxxxTGGAEPTIDVSMCP--------------------------- -------------------------------------------------- ----------------------YRCKGTGGQILVNGRDRSKRSLDEFYRL SCYIMQDDHLREVLTARESMSIASSLKLxxxx------------------ -----------------------------------------SSKEREA-- --------------------------QIEELLEMLGLSECQKTRCGQLSG GQKKRLSIALELISNPPVLFLDEPTTGLDSSSCSQCIALLKQLAQDGRTV ICTIHQPSAKIFEMFDHLYTLSEGRCVYQGNIAGLMPFLEGFGLHCPPYH NPADFLLEAATGEFGTEVSTLALAAESLKRTEERST-------------- -----------------------------ILRSQYKYYTTDFEASLAKET QKDPTQNNGAVVDKGEDVAISINKPASVWNQFLIIYLRNLVIMRRDYSNV MIRVLAHLLIGLLFGYLYKGVGNNGNTVLANYVYIYGSTLFLVYTGKMSV MLM-------------FPLEFQMLTREHFNRWFSLPPYLLSVILVEAPIQ VISSLMYLVISYVLTDQIMEPQRMGLFIMLGVTVSLTAQSAGFLVGVTTP IKIAVFLGPMVACLLSMFGFNIFFRDTPYLLRWIFHISYFRAAFQGSVFA MYGLNRTNLDCDILYCHMKLPSKILQTLDMEDVDIWGNMEMLVGVWCLIH LSTIIAIWFRLNKR------------------------------------ -------------------------------------------------- -------------------------------------------------- --- >Tte M------------------------------------------------- -------------------------------------------xxxxxxx xxxxxxxxxxxxxxxxxxxxxxx--------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -----------xxxxxxxxxxxx--------------------------- -------------------------------------------------- ----------------------YRCKGTGGQILVNGRDRSKRSLDEFYRL SCYIMQDDHLREVLTARESMSIASSLKLxxxx------------------ -----------------------------------------STKEREA-- --------------------------QIEELLEMLGLSECQKTRCGQLSG GQKKRLSIALELISNPPVLFLDEPTTGLDSSSCSQCIALLKQLAQDGRTV ICTIHQPSAKIFEMFDHLYTLSEGRCVYQGNIAGLMPFLEGFGLHCPPYH NPADFLLEAATGEFGTEVSTLALAAESLKRTEERST-------------- -----------------------------ILRSQYKYYTTDFEASLAKET QKDPTQNNGAVVDEGKDVAISINKPASVWNQFLIIYLRNLVIMRRDYSNV MIRVLAHLLIGLLFGYLYKGVGNNGNTVLANYVYIYGSTLFLVYTGKMSV MLM-------------FPLEFQMLTREHFNRWFSLPPYLLSVILVEAPIQ VISSLMYLVISYVLTDQIMEPQRMGLFIMLGVTVSLTAQSAGFLVGVTTP IKIAVFLGPMVACLLSMFGFNIFFRDTPYLLRWIFHISYFRAAFQGSVFA MYGLNRTNLDCDILYCHMKLPSKILQTLDMEDVDIWGNMEMLVGVWCLIH LSTIIAIWFRLNKR------------------------------------ -------------------------------------------------- -------------------------------------------------- --- >Tdi x------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ------------------------KGGLDSSSCSQCVALLKRLAQDGRTV ICTIHQPSAKIFEMFDHLYTLSEGRCVYQGSIVELMPFLEGFGLQCPPYH NPADFLLEAATGEFGTEVSTLAQAAESLKRTEERST-------------- -----------------------------KLRSQYKYYATDFEASLAKEK QKDPTQNNGAVVDEGEDVSISINKPASVWDQFLIIYLRNLVIMRRDY--- -------------------------------------------------- ------xxxxxxxxx----------------------------------- -------------------------------------------------- -------------------------------------------------- ---------------------------------------------xx--- -------------x------------------------------------ -------------------------------------------------- -------------------------------------------------- --- >Tce x------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------xxxxxxxx----- -----------------------------------------SSKEREA-- --------------------------QIEELLEMLGLSECQKTRCAQLSG GQKKRLSIALELISNPPVLFLDEPTTGLDSSSCSQCVALLKQLAQDGRTV ICTIHQPSAKIFEMFDHLYTLSEGRCVYQGSIVELMPFLEGFGLQCPPYH NPADFLLEAATGEFGTEVSTLALAAESLKRTEERSTxxxxxxxxxxLGLN TNLPIFDNPxxxxxxxxxxxxTEVGxxxxx--------------SLAKEK QKDPTQNNGAVVDEGEDVAISINKPASVWDQFLIIYLRNLVIMRRDYSNV TVRVLAHLLIGLLFGYLYKGVGNNGNTVLANYVYIYGSTLFLVYTGKMSV MLM-------------FPLEFQMLTREHFNRWYSLPPYLLSVILIEAPIQ VISSLMYLVISYLLTDQIMEPQRMGLFIMLGVTVSLTAQGAGFLVGVTTP IKIAVFLGPMLACLLSMFGFNIFFRDTPYLLRWLFHISYFRAAFQGSVFA MYGLNRTNLECDILYCHMKLPSKILQTLDMEDVDIWGNMEMLVGMWCLIH LTTIVAIWFRLNRR------------------------------------ -------------------------------------------------- -------------------------------------------------- ---