>Tge -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -----MFGFQHLRRIRGDNYCGVRAAIFQTLSQGHQIPGGNATFEHLSRA VNNNNCGWLKNWKFASRLPYQRNNVLHGMKACLQSLDNLISLLSSERNRE EALVNILTSDPLIDLHIMEAVKLHMLHRAMELHQANSNGYDVPLFAVLMF SRDTSETPKDFMNNHLSEVGNSGGLE------------------------ -------------------------------------------------- -------------------------------------------------- ---------------xxxxxxxxx-------------------------- -------------------------------------------------- -------------------------------------------------- -----x >Tte x------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ---------------xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx xxxxxxxxxxxxxxxxxxxxxVKYFGANTLSPDKSLSETTNRSKHVTYKP SSISAKLQQLLRNHVLSAGLSWPSTMESKSYVKKTANKDKYPVSKRKEEN TKYLRFDSHGSVADANFDNQSTSISHTQDFFSLSLDPPQQARDEIFDSLS CSRHITRNGSFDSASSEFSLDFSIPESLSDANIVNMEKIQKEIDSLNSKF LEMDEEIETIKSNRNLPGMSSLMEANTPRRKPLGINEDLPQDMEITETLK QQNARACFAGLYSLTTIKNSASSDLSDSLSTSIHKQGSVGSTESLVWDSP KIL----------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ------------------------------------------------GY AEIQSMFGFQHLRRIRGDNYCGVRAAIFQTLSQGHQIPGGNATFEHLSRA VNNNNCGWLKNWKFTSRLPYQRNNVLHGMKACLQSLDNLISLLSSERNRE EALVNILTSDPLLDLHIMEAVKLHMLHRAMELHQANSNGYDVPLFAVLMF SRDTSETPKDFMNNHLSEVGNSGGLE------------------------ -------------------------------------------------- -------------------------------------------------- ---------------xxxxxxxxx-------------------------- -------------------------------------------------- -------------------------------------------------- -----x >Tbi -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx xxxxxxxxxxxxxxxxxxxxxVKYFGANTLSPDKSLSETTNRSKHVTYKP SSISAKLQQLLRNHVLSAGLSWPSTMESKSYVKKTANKDKYPVSKRKEEN TKYLRFDSHGSVADANSDNQSTSISHTQDFFSLSLDPPQQARDEIFDSLS CSRHITRNGSFDSASSEFSLDFSIPESLSDANIVNMEKIQKEIDSLNSKF LEMDEEIETIKSNRNLPGMSSLMEANTPRRKPLGINEDLPQDMEITETLK QQNARACFAGLYSLTTIKNSASSDLSDSLSTSIHKQGSVGSTESLVWDSP KIL----------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ------------------------------------------------GY AEIQSMFGFQHLRRIRGDNYCGVRAAIFQTLSQGHQIPGGNATFEHLSRA VNNNNCGWLKNWKFTSRLPYQRNNVLHGMKACLQSLDNLISLLSSERNRE EALVNILTSDPLLDLHIMEAVKLHMLHRAMELHQANSNGYDVPLFAVLMF SRDTSETPKDFMNNHLSEVGNSGGLEQ----------------------- -------------------------------------x------------ -----------------------x-------------------xxxxxxx xxxxxxxxxxxxxxxx---------------------------------- -------------------------------------------------- -------------------------------------------------- ------ >Tpa xxx----------------------------------------------- -------------------------------------------------- ---QWVDEASDSFEASNSNQVGFMEMISFSVDPQWCGLLFSIYWRHEKGF LLGGSTFPQHDAFAACSFIGPPADTDWIALAGSVGIEICRLSSSWALIFx xx------------------------------------------------ -------------------------------------------------- KATGVILLLGFGSIVCYKVFRHCWQNCFSTKSPPDSPTTTxxxxSTAASD RHLLExxxxxxLxxxx---------------------------------- -------------------------------------------------- ---------------------VKYFGANTLSPDKSLSDTTNRSKHVTYKP SSISAKLQQLLRNHVLSAGLSWPSTIESKSYFKKTANKDKYPVSKRKEEN TKYLRFDSHGSVADANFDNQSTSISHTQDFFSLSLDPPQQARDEIFDSLS CSRHITRNGSFDSASSEFSLDFSIPESLSDANIVNMEKIQKEIDSLNSKF LEMDEEIETIKSNRNLPGMSSLMEANTPRRKPLGINEDLPQDMEITETLK QQNARACFAGLYSLTTIKNSASSDLSDSLSTSIHKQGSVGSTESLVWDSP KILVSPLKVPLNNVPEDCYVKYTNDIEECIPLNDCSKNEITGSIESPLKE SEITLENSSKPKWPLTSSNSLTFDSTEADFMANLEWDEEDLVVYSEGDDA TLGDTENIVNPDSKDMMSLDLNEVPYTHDALFTHHLNRSCEDSPLESSFQ TNSGGSESLVLETSMSTLSSDSTLLSEWDVNTCESTNESGFLEWDESTYH SNLHVLQDGKLYEKSATVEDESPRNESVPLNLGSPSTENTISATDNVGP- ------------------------KIKILQYAYQEWRGGTKKADTILKGY AEIQSMFGFQHLRRIRGDNYCGVRAAIFQTLSQGHQIPGGNATFEHLSRA VNNNNCGWLKNWKFASRLPYQRNNVLHGMKACLQSLDNLISLLSSERNRE EALVNILTSDPLLDLHIMEAVKLHMLHRAMELHQANSNGYDVPLFAVLMF SRDTSETPKDFMNNHLSEVGNSGGLEQ----------------------- -------------------------------------x------------ -------------------xxxxx-------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ------ >Tsi MKATTTEDGAAGxxTVLRRxxxxLLILxxVxxFFQxxx------------ -------------------------------------------------- --xQWVDEASDSFEASNSKEVGFMEMISFSVDPQWCGLLFSIYWRHEKGF LLGGSTFPQHDAFAACSFLGPPADTDWIALAGSVGIEICRISSSWALIFx xxEQLVILYWKNNRVTSNTLSPFFATAKC--------------------- -------------------------------------------------x KATGVILLLGFGSIVCYKVFRHCWQNCFSTKSPPDSPTTSxxxxxTAVSD IHLLEDLxxIDLDDxxxxx------------------------------- -------------------------------------------------- ---------------------VKYFGANTLPPDKSLSDTIKRSNHVTQTP SSISAKLQQLLRDHVLSAGLSWPSTIESKSHLKKTANKDKYPVSKRKEEN TKYLRFDPHGSGVDTYFDNQSTGISHTQDFFSLSLDPPQLARDEIFDSLS CSRHITRNGSFDSASSEFSLDFSIPESLSDANIVNMEKIQKEIDSLNSKF LEMDEEIETIKSNRNLPGMSSLMEANTPRRKPLGLNEDLPQDMEITETLK QQNARACFAGLYSLTTIKNSASSDLSDSLSTSIHKQGSVGSTESLVWDSP KIL----------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ------------------------------------------------GY AEIPSMFGFQHLRRIRGDNYCGVRAAIFQTLSQGHLVPGGSATFEHLSRA VNNNNCGWLKNWKFASRLPYQRNNVLYGMKACLQSLDNLISLLSSERNRE EALVNILTSDPLLDLHIMEAVKLHMLHRAMELHQANSNGYDVPLFAVLMF SRDTSETPKDFMNNHLSEVGNSGGLEQ----------------------- -------------------------------------xxxxxxxxxxxVT LTVVRPSAxxxDDFVCSYPDWxxxxxxxxxLVAEDDRHYNVLVE------ -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ------ >Tcm xIS----------------------------------xxxVKIETYWIDA xxxxxLVGSVGWPHRSxxxxxxxxxDDHxxxxxRxxxxxxxxxxxxxxxx xxxHWVDEASDSFEASNSKEVGFMEMISFSVDPQWCGLLFSIYWRHEKGF LLGGSTFPQHDAFAACSFLGPPADTDWIALAGSVGIEICRISSSWxLIFx xxEQLVILYWKNNRVTSNTLSPFFATAKCRSRGGGGDLGVQKPHEIQLGG VPPQPPPLKLLACYGLGVLH----------------------------Sx KATGVILLLGFGSIVCYKVFRHCxxxxxxxxxxxDxxxxxxxxxxxxxxx xxxxxxxxxxxxxxxxxxx------------------------------- -------------------------------------------------- ---------------------VKYFGANTLPPDKSLSDTIKRSNHVTQTP SSISAKLQQLLRDHVLSAGLSWPSTIESKSHLKKTANKDKYPVSKRKEEN TKYLRFDPHGSGVDT----------------------------------- ---HITRNGSFDSASSEFSLDFSIPESLSDANIVNMEKIQKEIDSLNSKF LEMDEEIETIKSNRNLPGMSSLMEANTPRRKPLGLNEDLPQDMEITETLK QQNARACFAGLYSLTTIKNSASSDLSDSLSTSIHKQGSVGSTESLVWDSP KILVSPLKVPLNNVPEDCYVEYTNDIEECIPLNDCYTNEITGSIESPLKE NKITLENSSKPKWPLTSSNSLTFDSTEADFMANLEWDEEGLVVYSEVDDS TLGATENIVNPDSKDMMSLDLNEVPYTRDALFTHHLNRSCEDSPLESSFQ TNSGGSESLVLETSVSTLSSDSTVLSEWDVNTYESTNESGFLDWDExxx- xxxxxxxxxxxxxxxxxxEVESPRNESVPLNLVSPSTENTISANDN---- ------------------------------------------------GY AEIPSMFGFQHLRRIRGDNYCGVRAAIFQTLSQGHLVPGGSATFEHLSRA VNNNNCGWLKNWKFASRLPYQRNNVLYGMKACLQSLDNLISLLSSERNRE EALVNILTSDPLLDLHIMEAVKLHMLHRAMELHQANSNGYDVPLFAVLMF SRDTSETPKDFMNNHLSEVGNSGGLEQx---------------------- -----------------------------------xxxxxxxxxxxxGVT LTVVRPSAxxxDDFVCSYPDWNQGIWxxxxLVAEDDRHYNVLVx------ -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ------ >Tdi xxx----------------------------------------------- -------------------------------------------------- ---QWVDEASDSFEASNSKEVGFMEMISFSVDPQWCGLLFSIYWRHEKGF LLGGSTFPQHDAFAACSFLGPPADTDWIALAGSVGIEICRISSSWALIFx x------------------------------------------------- ------------------xHPTEIRTLISPSSAVELNTTSALANYATEAx KATGVILLLGFGSIVCYKVFRHCWPNCFSTKSPPDSPTTSxxxxxTAVSD IHLLEDLxxxDLxx------------------------------------ -------------------------------------------------- ---------------------VKYFGANTLSPDKSLSDTIKRSNHVTQTP SSISAKLQQLLRDHVLSAGLSWPSTIESKSHLKKTANKDKYPVSKRKEEN TKYLRFDPHGSGADTYFDNQSTGISHTQDFFSVSLDPPQLARDEIFDSLS CSRHITRNGSFDSASSEFSLDFSIPESLSDANIVNMEKIQKEIDSLNSKF LEMDEEIETIKSNRNLPGMSSLMEANTPRRKPLGINEDLPQDMEITETLK QQNARACFAGLYSLTTIKNSASSDLSDSLSTSIHKQGSVGSTESLVWDSP KIL----------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ------------------------------------------------GY AEIPSMFGFQHLRRIRGDNYCGVRAAIFQTLSQGHLVPGGSATFEHLSRA VNNNNCGWLKNWKFSSRLPYQRNNVLYGMKACLQSLDNLISLLSSERNRE EALVNILTSDPLLDLHIMEAVKLHMLHRAMELHQANSNGYDVPLFAVLMF SRDTSETPKDFMNNHLSEVGNSGGLEQ----------------------- -------------------------------------------------- -------------------------------------------------- -----------------------xxxxxxxxxxxxxxYRNFxxxxxxxxx xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxExxxxxxNFTMxxxx xxxxxxxxTxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx xxxxxx >Tps x------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------SW----- -------------------------------------------------- ------------------xxxx---------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ---------------------VKYFGANTLSPDKSLSDTIKRSNHVTQTP SSISAKLQQLLRDHVLSAGLSWPSTIESKSHLKKTANKDKYPVSKRKEEN TKYLRFDPHGSGADTYFDNQSTGISHTQDFFSVSLDPPQLARDEIFDSLS CSRHITRNGSFDSASSEFSLDFSIPESLSDANIVNMEKIQKEIDSLNSKF LEMDEEIETIKSNRNLPGMSSLMEANTPRRKPLGINEDLPQDMEITETLK QQNARACFAGLYSLTTIKNSASSDLSDSLSTSIHKQGSVGSTESLVWDSP KILVSPLKVPLNNVPEDCYVEYTNDIEECIPLNDCYKNEITGSIESPLKE NKITLENSSKPKWPLTSSNSLTFDSTEADFMANLEWDEEGLVVYSEVDDS TLGATENTLNPDSKDMMSLDLNEVPYTRDTLFTHHLNRSCEDSPLESSFQ TNSGGSESLVLETSVSTLSSDSTVLSEWDVNTYESTNESGFLDWDExxx- xxxxxxxxx---------------------------------------xx xxxxxxxxxxxxxxxxxxxxxxxxx-----------------------xx x------------------------------------------------- ---------------------------------------ISLLSSERNRE EALANILTSDPLLDLHIMEAVKLHMLHRAMELHQANSNGYDVPLFAVLMF SRDTSETPKDFMNNHLSEVGNSGGLEQxxxxxxxxxxxxxxxxxxGxGTN DITVDxxxxxxSFTMALYEFSFLWTPQTVPIWxxxxxxxxxxxxxxxxVT LTVVRPLAxxxDDFVCSYPDWNQGIWxxxxLVAEDDRHYNVLVE------ -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ------